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Nucleoside analogues are nucleosides which contain a nucleic acid analogue and a sugar. Nucleotide analogs are nucleotides which contain a nucleic acid analogue, a sugar, and one to three phosphate groups.
1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment
ActiveUS20120263678A1Improve cell selectivityInhibition of replicationBiocideSugar derivativesPyrimidineNucleoside Analogs
Provided are compounds of Formula I:nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.
Owner:GILEAD SCI INC