28 results about "Sodium methoxide" patented technology

This invention discloses a method for preparing sodium houttuynia cordata, comprising the following steps: adding sodium methoxide and toluene to a reaction vessel, heating, then slowly adding nonanone and ethyl formate, and after the addition is complete, reacting with a gradient cooling process, and post-processing to obtain an aqueous phase containing intermediate I; adding the aqueous phase containing intermediate I and toluene to the reaction vessel, stirring, cooling, and rapidly introducing liquid sulfur dioxide, continuously stirring and reacting at 0-10°C for 5-15 minutes, cooling, and filtering to obtain crude sodium houttuynia cordata. The preparation method of this invention directly introduces liquid sulfur dioxide during the sulfonation reaction, greatly shortening the process time, while achieving high product yield and purity, and requiring less sulfur dioxide. Furthermore, in the post-processing of sodium houttuynia cordata, adding toluene to the reaction solution beforehand can effectively transfer the generated impurities to the toluene; recrystallization using a 50 v / v% ethanol aqueous solution removes water-soluble and oil-soluble impurities while further reducing the risk of fire and explosion during centrifuge operation.

The utility model discloses a steam delivery device for sodium methoxide synthesis, include: gas pipe, the first joint subassembly of assembly on gas pipe, the first joint subassembly is used for transportation sodium alcohol, above -mentioned device through the air pressure of straight cylinder inside heightening, promote the cylindrical air bag in air bag part to the gas pipe direction removal. Cylindrical air bag is closely combined with the inner wall of gas pipe in the moving process, under the push of air pressure, the methanol steam remaining in gas pipe is pushed forward and is arranged in sodium methoxide synthesis tower. At this moment, the area increasing groove on cylindrical air bag can effectively increase the contact area with the inner wall of gas pipe, enhance the leakproofness, reduce steam leakage, and the air pressure balance pipe can balance the air pressure in air bag part, avoid the air bag to break because of excessive pressure. Even if the air bag part of multiple has one because of accidental breakage, other unbroken air bag part still can keep good leakproofness, continue to play the sealing and pushing and shoving effect, ensure that the methanol steam in gas pipe can be effectively discharged.

This invention discloses a method for preparing the DPP1 inhibitor bresocarte, belonging to the field of pharmaceutical synthesis. Specifically, the method includes the following steps: N-tert-butoxycarbonyl-L-4-bromophenylalanine reacts with methanesulfonyl chloride or 4-nitrobenzenesulfonyl chloride in the presence of a base, followed by amination substitution to obtain intermediate 1; then, it undergoes dehydration in the presence of trifluoroacetic anhydride to obtain intermediate 2; next, it undergoes a coupling reaction with pinacol diboronate to obtain intermediate 3; then, it undergoes a coupling reaction with bromide compound 4 to obtain intermediate 5; then, it undergoes cyclization with di-tert-butyl dicarbonate in the presence of sodium methoxide to obtain intermediate 6; then, it undergoes deprotection in the presence of hydrogen chloride to obtain intermediate 7; next, it undergoes condensation with compound 8 to obtain intermediate 9; finally, it undergoes deprotection in the presence of hydrogen chloride to obtain the inhibitor bresocarte. This method provides a new synthetic approach, with low overall cost, simple operation, high yield, and suitability for industrial production.

This invention belongs to the field of cycloazinone preparation technology, and provides a high-yield cycloazinone synthesis process, including the following steps: Step 1: N-ethoxycarbonyl-N,N,N-trimethylguanidine and a solid-phase catalyst are added to toluene and stirred evenly. Under nitrogen protection, the temperature is raised to 40-60°C, and a cyclohexyl isocyanate toluene solution is added dropwise. Stirring is continued for 2-4 hours. The solid-phase catalyst is recovered by filtration, and the mixture is concentrated under reduced pressure to obtain N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine; Step 2: Under nitrogen protection, the temperature is raised to 50-60°C, and the N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine toluene solution is added dropwise to a sodium methoxide toluene solution and stirred for 1-2 hours. The temperature is lowered to room temperature, and glacial acetic acid is added for neutralization. After washing, the mixture is concentrated under reduced pressure, and a crystallizing agent is added. The temperature is lowered to 0-5°C, and the mixture is stirred for crystallization for 2-4 hours. After filtration and washing, the mixture is dried under vacuum to obtain the finished cycloazinone.

The utility model relates to sodium methoxide preparation technology field of alkali method, proposes a kind of production equipment for sodium methoxide preparation of alkali method, including support frame, the right lower end inner wall of support frame is installed connection has positive and negative motor, and the output of positive and negative motor is connected with the middle shaft installation of driving gear, the lower end of blanking is connected with cooling structure by mechanical seal, electric telescopic handle is installed on the upper end inner wall of mounting bracket, cooling structure includes installation cylinder, cooling bar and cooling leaf, the upper end of elastic collection bag is integrally fixed connection with the lower end inner wall of inlet, the front and rear ends of roll pressure wheel are integrally fixed connection with adjusting gear. The production equipment for sodium methoxide preparation of alkali method, when producing preparation to sodium methoxide solution, improve the efficiency of sodium methoxide solution stirring dissolution, control the temperature inside reaction device stably simultaneously, avoid the occurrence of safety accident, improve the security of production.

The utility model relates to a waste heat recovery technical field, proposes a kind of waste heat recovery device of waste gas in sodium methoxide production process, including distillation column body: the one side of distillation column body is fixedly connected with two connecting pipes one, the other side of two the connecting pipe one is respectively fixedly connected with heat exchange tube one and heat exchange tube two, heat exchange tube one and heat exchange tube two between fixedly connected with connecting pipe three, the inside fixedly connected with water delivery valve of connecting pipe three, the one side fixedly connected with water inlet two of heat exchange tube two, the one side fixedly connected with water outlet of heat exchange tube one, since hot waste gas is discharged by distillation column body first into the inside of heat exchange tube one and heats, when reaching heat exchange tube two inside, it is the hot waste gas after cooling, at this time, by the cold water of water inlet two can make the hot waste gas after cooling more thorough cooling.

The application provides a synthesis process of an ocinaplon intermediate. S1, petroleum ether, methanol and ethyl formate are mixed to obtain a mixed system, ortho-phenyltoluene and sodium methoxide are added, and reaction is carried out to obtain intermediate 1; S2, intermediate 1 is added into methanol, a palladium-carbon catalyst is added, hydrogen is introduced, and reaction is carried out to obtain intermediate 2; S3, phosphoric acid and a supported catalyst are added into intermediate 2, and reaction is carried out to obtain iminodibenzyl. The problem of low iminodibenzyl yield in the prior art is solved.

This utility model discloses a high-pressure cleaner for preparing sodium methoxide, relating to the field of high-pressure cleaner technology. It includes a working chamber and lifting handles fixedly connected to both sides of the working chamber surface. This utility model utilizes a water pump output to connect to a water source. The working rod is then extended to the area requiring cleaning, allowing water to enter the connecting pipe and fill the spray pipe. Water is then forcefully sprayed out through a rectangular nozzle from the inside of the pressurized pipe to clean the area. When the cleaning area needs to be expanded, a motor drives a driven gear via a drive gear, causing the transmission rod on the surface of the connecting pipe to rotate. This, in turn, causes the drive bevel gear to drive two driven bevel gears, resulting in rotation. Finally, the transmission pipe drives the spray pipe to rotate and spray, allowing the device to autonomously expand the cleaning area and address different cleaning dead zones, thus improving both the cleaning effect and the cleaning capacity.

The application belongs to the technical field of hydrogen sulfide and peroxynitrite ion detection, and specifically discloses a near-infrared fluorescent probe DCI-TSO based on an ICT mechanism, a preparation method and application, and comprises the following steps: S1, synthesizing compound 1; S2, synthesizing compound 2; S3, synthesizing compound 3: dissolving compound 1 obtained in S1 and compound 2 obtained in S2, and adding dropwise 1,8-diazabicyclo[5.4.0]-7-undecene reaction; S4, synthesizing compound 4; S5, synthesizing probe DCI-TSO: dissolving compound 3 obtained in S3 and compound 4 obtained in S4, and adding dropwise sodium methoxide under stirring reaction at room temperature in a protective atmosphere. The application adopts the above-mentioned near-infrared fluorescent probe DCI-TSO based on an ICT mechanism, a preparation method and application, and can detect H2S and ONOO ‑ with good optical properties and biocompatibility, and has great commercial value.

This utility model discloses a workshop drying device for sodium methoxide preparation, relating to the field of sodium methoxide preparation. It includes a base plate, a hot air blower, and a drying chamber fixedly connected to the top surface of the base plate. An air supply pipe is fixedly connected to the output end of the hot air blower. One end of the air supply pipe extends into the interior of the drying chamber and is fixedly connected to a flow divider shell. The top surface of the flow divider shell is fixedly connected to the top surface of the inner wall of the drying chamber, and multiple air outlets are provided on the bottom surface of the flow divider shell. This utility model allows for the rapid disassembly of the drying frame after sodium methoxide drying by installing components inside the drying chamber, facilitating material handling by workers. Simultaneously, a drive component controls the reciprocating movement of the drying frame, and the rapid return characteristic of the drying frame during movement causes the sodium methoxide inside the drying frame to flip over, effectively ensuring the uniformity of sodium methoxide drying.

This invention provides a method for preparing benzo[5]-type nitrogen-containing heterocyclic compounds, comprising the following steps: 1) reacting compound 1 with sodium methoxide to obtain compound 2; 2) subjecting compound 2 to reduction and acidification to obtain hydrochloride compound 3; 3) coupling compound 3 with compound 9 to obtain compound 4; 4) removing the protecting group from compound 4 to obtain compound 5; 5) obtaining compound 6 from compound 5; 6) cyclizing compound 6 to obtain compound 7; 7) obtaining compound 8 from compound 7; the reaction route is as follows. This method avoids the use of expensive reagents, greatly reduces production costs, and is very suitable for industrial production.

This invention discloses the preparation and application of a base-sensitive linker arm for solid-phase synthesis of polysaccharides, belonging to the fields of glycochemistry and solid-phase synthesis technology. This invention provides a base-sensitive linker arm system comprising an ester core, a linker, and a solid-phase support; one end of the ester core is connected to the solid-phase support, and the other end is connected to the linker; one end of the linker is connected to the ester core, and the other end contains exposed hydroxyl groups; the linker arm system of this invention uses phthalates or alkyl esters as the base-sensitive core structure, which can be cleaved under sodium methoxide conditions, and after hydrogenation deprotection, retains free anomeric sites at the ends of the polysaccharides, or provides amino and carboxyl groups for subsequent preparation of glycoconjugates and glycochips. During the cleavage of the linker arm, the ester protecting groups of the polysaccharide can be removed simultaneously, simplifying the deprotection step and improving efficiency and yield.

The utility model discloses a high -efficient sodium methoxide reaction tower with layered feed structure, include: tower body, the layered feed subassembly of assembly on tower body, the layered feed subassembly is used for to liquid layered injection and shunt, the reaction heating subassembly of assembly in tower body inside, the above -mentioned device passes through caustic soda and methanol mixed solution and enters the hopper through the liquid inlet pipe, then under the driving of the pivot, the liquid distribution plate in the liquid distribution pot will even shunt liquid, and the layered injection is divided into two groups in the liquid outlet of symmetrical setting and enters the inside of tower body. Gas raw material enters the gas distributor through the gas inlet pipe, and after uniform dispersion, fully mixes with liquid in the tower body. In the tower body, liquid flows through three groups of layered feed subassembly, and reacts under the action of gas raw material in the reaction heating subassembly. The gas balance valve pipe of tower top adjusts air pressure, ensures that the pressure in the tower is stable, guarantees the smooth operation of the whole reaction process, thereby reaches the effect that the internal reaction raw material is mixed evenly.

The utility model discloses a sodium methoxide stirring cooling device belongs to sodium methoxide processing technical field, including bottom plate, the bottom plate is fixedly connected with support frame, install the rolling subassembly on the support frame, the rolling subassembly is placed with the stirring bucket, the cooling device is assembled outside the stirring bucket, the recovery device is assembled on the bottom plate. In the utility model, after processing is completed, by moving one of the through -orifice of stirring bucket to the extrusion block right above, the output shaft of electric push rod drives the push rod to make linear motion at this moment, and the extrusion block of push rod end applies axial thrust to sealing plug immediately, makes sealing plug to separate through -orifice, and after unsealing, the cooling liquid is discharged through the through -orifice under the action of gravity, flows to the surface of the protection board that is arranged obliquely first, and then is guided to the receiving box along the protection board, the centralized recovery of cooling liquid is completed, and the design guarantees the efficient heat exchange in the stirring process, and also realizes the automatic recovery of cooling medium.

The application relates to the technical field of roxadustat, and particularly discloses a preparation method of roxadustat, which comprises the following steps: S1, taking 4-bromobenzyl bromide as a starting raw material, refluxing 4-bromobenzyl bromide and sodium methoxide in methanol to prepare an intermediate 2; S2, subjecting the intermediate 2 to a Friedel-Crafts acylation reaction with acetic anhydride to prepare an intermediate 3; S3, subjecting the intermediate 3 to an Ullmann coupling reaction with phenol in toluene by using glycine copper as a catalyst to prepare an intermediate 4; the starting raw material is 4-bromobenzyl bromide, the raw material is easy to obtain and low in price, a low-cost conventional reagent is used as a catalytic system, and cheap catalytic systems are used in key reactions, and low-cost alkali-solvent combinations are selected for steps such as aminolysis, so that the preparation cost is greatly compressed from the aspects of raw materials and reagents.

This invention provides a continuous preparation method for N,N,N',N'-tetra(2-hydroxyethyl)hexamethylenediamide. Diethanolamine and a sodium methoxide catalyst are mixed in a first mixer, then mixed with dimethyl adipate in a second mixer before entering a continuous reactor for synthesis. After the reaction, the crude product is passed through a falling film evaporator for further reaction and removal of unseparated methanol byproducts, yielding high-purity liquid N,N,N',N'-tetra(2-hydroxyethyl)hexamethylenediamide. Finally, the product is granulated to obtain solid, commercially available granules. This invention solves the problem of continuous production in existing technologies, offering advantages such as short synthesis time, continuous granulation, and elimination of subsequent solidification, crushing, drying, and granulation processes, thus improving equipment efficiency.

The application discloses a sodium-based single-ion conducting polymer electrolyte PTB-S based on a boroxin skeleton and a preparation method and application thereof, TB is used as a boroxin precursor, sodium methoxide is used to generate TB-S1, TB-S2 and TB-S3 with sodium salt, TB-S is dissolved in TB to form a copolymer precursor electrolyte, in-situ copolymerization is induced by heat in a battery, PTB-S1, PTB-S2 and PTB-S3 are obtained, and B-O-Na + is constructed, a boroxin anion fragment is fixed on a skeleton through a covalent bond or a stable coordination mode, Na + is used as a main migration ion, single-ion conduction is realized, and a three-dimensional sodium ion transmission channel is formed, a Na||NFS full battery maintains a stable voltage platform and a high capacity retention rate under a medium current density, excellent interface stability and cycle life, a boroxin skeleton, TB-S monomer construction and single-ion conducting mechanism, and safe, long-life and high-power operation of a sodium metal battery.

This invention discloses a sodium methoxide solution distillation suction device, comprising a distillation suction device body, with a vacuum pump connected to the left side of the body. This invention involves placing a rubber tube into a sodium methoxide solution container, which then floats continuously on the surface via a float ring, preventing the absorption of impurities from the sodium methoxide solution. The user then activates the vacuum pump, which extracts air from the inside of the device body, creating a negative pressure environment. The sodium methoxide solution is then drawn through a metal tube and absorbed into the device body via an absorption hopper. Impurities in the solution are then purified using filter and purification plates, and the solution can be discharged and collected. This method replaces existing absorption methods that easily absorb impurities during the absorption process, thus avoiding the absorption of impurities during the absorption process.

The utility model is suitable for sodium methoxide production technical field provides a kind of sodium methoxide production reaction kettle, it include: jar body;Bottom bracket connected in the bottom end of jar body;Stirring assembly is assembled in the inside of jar body;Mounting assembly is assembled between jar body and bottom bracket;Output assembly is assembled in the downside of bottom bracket, and the output assembly is used to the even conveying of the material that stirring is completed.The sodium methoxide production reaction kettle provided in the scheme, by the cooperation of each device, effectively improve stirring capacity, while each component is quickly disassembled and cooperates, is favorable to improve cleaning and maintenance efficiency, shorten downtime, reduce maintenance cost, enhance equipment adaptability and flexibility, while, it is convenient to replace spare parts, guarantee operation safety, prolong equipment life, improve overall production efficiency and economic benefit.

The present application relates to the PTMEG production refining technical field, especially based on ion exchange PTMEG demethanol sodium process, solved the existing existing PTMEG demethanol sodium more using neutralization method and water washing method, neutralization method is easy to introduce impurities and precision is difficult to control, water washing method product loss, long process, high energy consumption, both cannot continuous production, the overall efficiency is low, the present application is through first by reaction rectification completes PTMEA alcoholysis conversion preparation PTMEG stock solution, again through precision filtration, cooling dilution homogenization pretreatment stabilizes material state, utilizes double distribution device double resin bed ion exchange system cooperation online sodium ion real-time detection accurate removal sodium ion, resin failure adopts standardization multistage online flushing regeneration, double bed alternative switching operation whole process does not need to stop continuous operation, improves PTMEG overall production efficiency.

This invention discloses a heparin trisaccharide compound, its preparation method, and its applications, belonging to the field of compound preparation technology. The heparin trisaccharide compound is mainly prepared by the following method: linking a monosaccharide donor and a disaccharide acceptor through glycosylation, then reacting in a methanol / sodium methoxide system or a tetrahydrofuran / sodium hydroxide / water system, followed by sequential O-sulfonation, catalytic hydrogenation, and N-sulfonation post-treatment steps to obtain the heparin trisaccharide compound. This compound has a well-defined structure, a single component, and exhibits anti-angiogenic activity and anti-tumor potential.

This invention belongs to the field of drilling engineering plugging agent preparation technology, and particularly relates to a plugging agent for shale, its preparation method and application. The plugging agent preparation method includes (1) mixing modified silica with a first monomer mixture and carrying out a first reaction to obtain a first intermediate product; (2) adding a second monomer mixture to the first intermediate product and carrying out a second reaction to obtain a core-shell polymer; wherein, the ratio of the total mass of the first monomer mixture and the second monomer mixture to the mass of the modified silica is 100:(10-40); (3) mixing the core-shell polymer with sodium methoxide and carrying out an alcoholysis reaction. This invention achieves synergistic effect of plugging and chemical stability by constructing a multifunctional shell rich in cations, amide groups, hydroxyl groups and ester groups on the surface of modified silica. The dual mechanism of electrostatic attraction and hydrogen bonding enables the plugging agent to form a strong adsorption and difficult desorption firm plugging layer on the shale surface, resulting in good plugging effect.

The utility model discloses a kind of stirring devices for preparing sodium methoxide, comprising: reaction bucket, the side of the reaction bucket is equipped with nitrogen input assembly, the nitrogen input assembly includes, nitrogen cylinder is detachably installed in the side of the reaction bucket;The above device is sent into annular water pipe by nitrogen cylinder through gas pump with dry nitrogen, and uniform fine bubbles are emitted in the bottom of reaction bucket by multiple groups of fine spray head;Bubble rolls along the surface of conical guide plate and forms microjet, continuously disturbs edge dead angle, and the wet material particles accumulated are rolled into mainstream and pushed to central discharge port. At the same time, top air pressure balance top cover is extracted in real time through air pressure circulation pipe, and after drying through water vapor remover, it flows back, air pressure gauge and air pressure balancer maintain micro-positive pressure, avoid air backflow. Fine bubbles and mechanical stirring jointly act, so that solid-liquid is quickly mixed and uniformly heated, reaction time is shortened, product purity is improved, and whole process does not need to open cover and manual cleaning, safe and efficient.

The application discloses a drying device for sodium methoxide and relates to the technical field of sodium methoxide drying. The drying device for sodium methoxide comprises a mounting bin, a support is fixedly connected to the outer wall of the mounting bin, a fixed bin is fixedly connected to the outer wall of the support, the fixed bin is located at the top of the mounting bin, a placing plate is fixedly connected between the fixed bin and the mounting bin, a limiting ring is fixedly connected to the top of the placing plate, and a heating device is fixedly connected to the inner bottom of the mounting bin. The drying device for sodium methoxide sucks the boiling heat through the circular cover, filters the moisture in the rising air through the sponge layer, and then the water in the sponge layer slides along the inner wall of the circular cover and falls to the outside under the guidance of the circular cover, thereby achieving the effect of guiding the moisture to be discharged, avoiding the moisture from being discharged into the treatment bin again, and improving the evaporation efficiency of sodium methoxide.

This invention discloses a method for preparing methyl ethyl carbonate and diethyl carbonate via transesterification under ambient temperature and pressure. Using dimethyl carbonate and ethyl acetate as raw materials, and sodium methoxide or sodium ethoxide as a catalyst, the raw materials are continuously added to a reaction vessel at 5-25℃ and 0.1MPa±0.02MPa. The stirring rate is 50-100 r / min, the temperature fluctuation is ≤±1℃, and the material residence time is 5-30 minutes, reaching reaction equilibrium when the dimethyl carbonate conversion rate fluctuation is ≤±0.5%. After the reaction, the generated Na₂CO₃, NaHCO₃, and CH₃COONa mixed solids are removed by vacuum filtration, pressure filtration, or centrifugation. The equilibrium liquid is sent to a continuous distillation column for separation and purification through multi-column distillation to obtain methyl ethyl carbonate and diethyl carbonate. Unreacted raw materials are recycled, and the byproduct methyl acetate is sold as a chemical product. This invention features mild reaction conditions, low equipment requirements, high reaction efficiency, low energy consumption, simple separation, no azeotropic interference, high resource utilization, and is suitable for continuous production.