147 results about "Sodium methoxide" patented technology

This invention discloses a method for preparing a high-temperature resistant, strongly basic anion exchange resin, belonging to the field of ion exchange resins. The method includes three steps: First, white spheres with a crosslinking degree of 6-10 undergo a chloromethylation reaction by sequentially adding zinc dichloride and tin tetrachloride to improve the uniformity of the chloromethyl group distribution in the chlorospheres; second, the chlorospheres undergo an etherification reaction using tetrabutylammonium bromide as a phase transfer catalyst, and the dropping rate of sodium methoxide solution is controlled to improve the etherification conversion rate; finally, the etherification product undergoes a quaternization reaction with a trimethylamine aqueous solution to obtain the strongly basic anion exchange resin. This invention, by selecting the degree of crosslinking and optimizing the catalyst addition method for chloromethylation and the sodium methoxide dropping rate for the etherification reaction, results in a more uniform distribution of quaternary ammonium groups in the resin, significantly improving the ion exchange capacity and high-temperature resistance of the resin.

The invention belongs to a production system and a production process of sodium methoxide. Comprising a sodium methoxide reaction tower, a methine solution pipeline, a refined methanol pipeline and a sodium methoxide storage tank, the methine solution pipeline is connected with an inlet in the upper portion of the sodium methoxide reaction tower through a tube pass of a methanol reaction tower kettle liquid heat exchanger, and a liquid phase outlet in the bottom of the sodium methoxide reaction tower is connected with an inlet of a sodium methoxide reaction tower kettle liquid evaporator; a liquid phase outlet of the sodium methoxide reaction tower kettle liquid evaporator is connected with a sodium methoxide storage tank through a methanol reaction tower kettle liquid heat exchanger shell pass; the refined methanol pipeline is connected with a lower gas-phase inlet of the sodium methoxide reaction tower through a tower top heat exchanger shell pass of an amide rectifying tower in the amide production unit, and the refined methanol pipeline is connected with a lower gas-phase inlet of the sodium methoxide reaction tower through a bottom liquid heat exchanger tube pass of a methanol rectifying tower in the amide production unit; according to the thermodynamically coupled sodium methoxide-amide collaborative production system, a cross-device energy and material collaborative network is constructed, so that the double breakthrough characteristics of energy conservation and product quality improvement are realized.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of 1, 1-cyclohexyl diacetic acid. The preparation method comprises the following steps: taking cyclohexanone and ethyl cyanoacetate as raw materials to react and dehydrate to prepare a product 1, then reacting cyanoacetamide, sodium methoxide and the product 1 at low temperature to obtain a product 2, and then hydrolyzing the product 2 under the catalysis of a magnetic solid double-acid catalyst to obtain the 1, 1-cyclohexyl diacetic acid. The used magnetic solid double-acid catalyst is prepared by loading a metal active layer and a sulfonic acid group on a magnetic mesoporous silicon dioxide carrier step by step, and has Lewis acid and Bronsted acid sites, and the catalyst is separated by an external magnetic field after the reaction. The method is short in reaction time and high in catalytic efficiency, the catalyst can be recycled, the separation problem of traditional homogeneous acid catalysis is avoided, and the method has the advantages of being mild in reaction condition, high in yield, environmentally friendly and the like and is suitable for industrial production of 1, 1-cyclohexyl diacetic acid.

This invention discloses a method for preparing sodium houttuynia cordata, comprising the following steps: adding sodium methoxide and toluene to a reaction vessel, heating, then slowly adding nonanone and ethyl formate, and after the addition is complete, reacting with a gradient cooling process, and post-processing to obtain an aqueous phase containing intermediate I; adding the aqueous phase containing intermediate I and toluene to the reaction vessel, stirring, cooling, and rapidly introducing liquid sulfur dioxide, continuously stirring and reacting at 0-10°C for 5-15 minutes, cooling, and filtering to obtain crude sodium houttuynia cordata. The preparation method of this invention directly introduces liquid sulfur dioxide during the sulfonation reaction, greatly shortening the process time, while achieving high product yield and purity, and requiring less sulfur dioxide. Furthermore, in the post-processing of sodium houttuynia cordata, adding toluene to the reaction solution beforehand can effectively transfer the generated impurities to the toluene; recrystallization using a 50 v / v% ethanol aqueous solution removes water-soluble and oil-soluble impurities while further reducing the risk of fire and explosion during centrifuge operation.

The utility model discloses a steam delivery device for sodium methoxide synthesis, include: gas pipe, the first joint subassembly of assembly on gas pipe, the first joint subassembly is used for transportation sodium alcohol, above -mentioned device through the air pressure of straight cylinder inside heightening, promote the cylindrical air bag in air bag part to the gas pipe direction removal. Cylindrical air bag is closely combined with the inner wall of gas pipe in the moving process, under the push of air pressure, the methanol steam remaining in gas pipe is pushed forward and is arranged in sodium methoxide synthesis tower. At this moment, the area increasing groove on cylindrical air bag can effectively increase the contact area with the inner wall of gas pipe, enhance the leakproofness, reduce steam leakage, and the air pressure balance pipe can balance the air pressure in air bag part, avoid the air bag to break because of excessive pressure. Even if the air bag part of multiple has one because of accidental breakage, other unbroken air bag part still can keep good leakproofness, continue to play the sealing and pushing and shoving effect, ensure that the methanol steam in gas pipe can be effectively discharged.

The present invention relates to a method of preparing a heterogeneous linear carbonate, the method including performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst, wherein the catalyst is one or more selected from the group consisting of lithium methoxide (LME), lithium ethoxide (LEE), sodium methoxide (SME), sodium hydroxide (NaOH), and a mixture thereof, and the catalyst is input in a state of being dissolved in a sulfoxide-based solvent.

The invention relates to a water-soluble ultraviolet absorbent 4-disubstituted aminobenzyl subunit camphorsulfonic acid and a synthesis method and application thereof, and the synthesis method comprises the following steps: in a toluene-methanol mixed solvent, carrying out heating reflux reaction on camphorsulfonic acid and 2 equivalent weight of sodium methoxide, and after enolation conversion is completed, carrying out reduced pressure distillation to obtain the 4-disubstituted aminobenzyl subunit camphorsulfonic acid. Slowly dropwise adding a corresponding 4-disubstituted aminobenzaldehyde solution with the molar weight equal to that of camphorsulfonic acid, continuously heating and stirring to react for 6-12 hours, adding water to terminate the reaction, acidifying the reaction solution by using hydrochloric acid or sulfonic acid type cation exchange resin, separating to remove methylbenzene, adjusting the pH value of a water phase to about 6.5, performing rotary evaporation dehydration under reduced pressure, and extracting a crude product by using a conventional method; a target product can be obtained through column chromatography purification, and the target product not only has water solubility, but also has the characteristic of absorbing UVA and UVB ultraviolet light at the same time; the composition can be applied to sun-screening agent products, cosmetics or home care products, and also can be applied to various industrial products such as paint, varnish, plastics, textiles and rubber to improve the light resistance of the industrial products.

The invention provides a preparation method of fluoride ether bacteria amide, which comprises the following steps: dissolving pentafluorobenzonitrile in a solvent, dropwise adding a sodium methoxide solution at-10-30 DEG C for 2-15 hours, continuing to carry out heat preservation reaction for 0.5-2 hours after dropwise adding, and carrying out post-treatment to obtain 2, 3, 5, 6-tetrafluoro-4-methoxybenzonitrile; the preparation method comprises the following steps: jointly dissolving 2, 3, 5, 6-tetrafluoro-4-methoxybenzonitrile, 3-chloro-5-(trifluoromethyl) pyridine-2-yl) methanol and a catalyst acid in a solvent, reacting at 50-110 DEG C for 5-32 hours, and performing post-treatment on the obtained reaction liquid to obtain fluoride ether bacteria amide, according to the method, sodium methoxide and pentafluorobenzonitrile which are low in price and easy to obtain are subjected to etherification reaction, thionyl chloride and bis (trichloromethyl) carbonate are not used, the green chemical principle is met, and the method has the advantages of being short in step, safe and easy to operate and the like, so that the method has high implementation value and practical production applicability.

This invention relates to a safety control method and system for the preparation of ethyl methyl carbonate (EMC). The method involves feeding dimethyl carbonate into an EMC purification tower, monitoring the pressure within the tower, and adjusting the pressure if it falls outside a preset range. The purity of the output dimethyl carbonate is also monitored. The output dimethyl carbonate, a sodium methoxide / methanol solution, and anhydrous ethanol are mixed in a specified ratio in a raw material mixing unit to achieve the required homogeneity. Pressure and temperature are monitored in an EMC reaction tower; if these requirements are not met, pressure or temperature is adjusted. The bottom liquid from the EMC reaction tower is transferred to a waste catalyst concentration tank for further processing, and then to an EMC light-weight removal tower for further treatment. Temperature and pressure are monitored within the EMC light-weight removal tower; if the pressure falls outside a preset range, pressure or temperature is adjusted. After cooling, the final EMC product is obtained. This process ensures safe and stable production of ethyl methyl carbonate.

The invention discloses a polyurethane or polyurea aqueous dispersion with high humidity and heat resistance as well as a preparation method and application thereof. The aqueous dispersion is prepared by reacting the following components: a) polyester diol and / or polyol, b) di-and / or polyisocyanate which at least contains more than 50% by mass of toluene diisocynate, c) a monofunctional or polyfunctional polyethoxy chain segment-containing component which is synthesized by taking sodium methoxide as a catalyst and has reaction activity to isocyanate, and d) a polyethoxy chain segment-containing component which has reaction activity to isocyanate. D) a sulfonic acid type hydrophilic compound; e) a low molecular compound containing hydroxyl and containing at least two NCO reactive amino groups; wherein the ratio of the sodium ions in the component c) to the toluene diisocynate in the component b) is 10 ppm to 100 ppm. Sodium ions can catalyze a small amount of isocyanate groups to react with carbamate bonds to generate allophanate bonds in a polyurethane synthesis process, so that a trace cross-linked structure is introduced into a polyurethane chain segment, and the heat resistance / damp heat resistance of a product is improved.

The utility model discloses a hydrolysis device applied to sodium methoxide wastewater, which comprises a support, a reaction kettle arranged on the support, a feed port, a water inlet, an exhaust port and an oil discharge port sequentially arranged at the top of the reaction kettle, a discharge port arranged at the bottom of the reaction kettle, a guide rod vertically arranged in the reaction kettle, a sliding sleeve sleeved on the guide rod, and a lifting pipe arranged on the side surface of the sliding sleeve. The upper end of the lifting pipe is connected with one end of a telescopic hose, the other end of the telescopic hose is connected with an oil outlet formed in the top of the reaction kettle, a supporting plate is arranged on the side wall of the reaction kettle, a first motor is arranged on the supporting plate, and an output shaft of the first motor penetrates through the side wall of the reaction kettle and extends into the reaction kettle. One end of the pulling rope is connected with the winding drum, and the other end of the pulling rope is connected with the sliding sleeve. The device disclosed by the utility model is high in hydrolysis efficiency, and the hydrolyzed oil phase and water can be quickly separated, so that the efficient recycling of the sodium methoxide wastewater is realized.

This invention discloses a method for preparing the DPP1 inhibitor bresocarte, belonging to the field of pharmaceutical synthesis. Specifically, the method includes the following steps: N-tert-butoxycarbonyl-L-4-bromophenylalanine reacts with methanesulfonyl chloride or 4-nitrobenzenesulfonyl chloride in the presence of a base, followed by amination substitution to obtain intermediate 1; then, it undergoes dehydration in the presence of trifluoroacetic anhydride to obtain intermediate 2; next, it undergoes a coupling reaction with pinacol diboronate to obtain intermediate 3; then, it undergoes a coupling reaction with bromide compound 4 to obtain intermediate 5; then, it undergoes cyclization with di-tert-butyl dicarbonate in the presence of sodium methoxide to obtain intermediate 6; then, it undergoes deprotection in the presence of hydrogen chloride to obtain intermediate 7; next, it undergoes condensation with compound 8 to obtain intermediate 9; finally, it undergoes deprotection in the presence of hydrogen chloride to obtain the inhibitor bresocarte. This method provides a new synthetic approach, with low overall cost, simple operation, high yield, and suitability for industrial production.

The invention discloses a preparation method of a cresol trozole trisiloxane intermediate, and belongs to the technical field of fine chemical engineering. The preparation method comprises the following steps: by taking 2, 6-dibromo-4-methylphenol as a raw material, reacting with 3, 4-dihydropyran under the action of p-toluenesulfonic acid, so as to generate an intermediate 2-(2, 6-dibromo-4-methylphenoxy) pyran; reacting with sodium methoxide under the action of a catalyst to generate an intermediate 2-(2-bromo-4-methyl-6-methoxyphenoxy) pyran; then generating a Grignard reagent, carrying out coupling reaction on the Grignard reagent and 3-bromine-2-methallyl, finally reacting with benzotriazole lithium salt, and carrying out acidolysis deprotection to obtain the cresol trozole trisiloxane intermediate. The raw materials are available in the market, the overall yield is high, and a route reference is provided for synthesis of the compounds.

The application discloses a kind of carbon quantum dot materials and its preparation method and application, specifically related to the field of battery material.It includes: p-xylylene formaldehyde and p-trifluoromethyl phenyl cyanide acetonitrile are placed in sodium methoxide solution to carry out hydrothermal reaction, obtain carbon quantum dot material;PAN powder is mixed with DMF to obtain PAN spinning solution;Carbon quantum dot material is dispersed in PAN spinning solution, to obtain mixed spinning liquid;Mixed spinning liquid is spun on the surface of zinc foil by electrostatic spinning, to obtain modified zinc foil.Carbon quantum dot material rich in multiple types of zincophilic functional groups synthesized by hydrothermal method strategy can improve the electric field distribution of zinc metal surface, and then uniform zinc ion deposition and nucleation process, avoid zinc dendrite formation, use modified zinc foil as the anode material of aqueous zinc ion battery, and carbon quantum dot material with abundant negative electric functional groups can repel sulfate ions in electrolyte, to inhibit the formation of byproduct.

The application belongs to the technical field of chemical industry, and particularly relates to a mixed cresol separation method, which comprises selective oxidation, filtration, neutralization, secondary filtration and rectification processes in sequence. The selective oxidation comprises: adding mixed cresol, sodium hydroxide, sodium methoxide, a solvent and a catalyst into an oxidation kettle, heating, and introducing oxygen for selective oxidation. In the selective oxidation step, sodium methoxide is added, which can react with water obtained in a salification reaction step (i.e. a reaction step of sodium hydroxide and mixed cresol to generate sodium phenate and water) to generate methanol and sodium hydroxide, thereby promoting the selective oxidation reaction and improving the yield.

This invention belongs to the field of cycloazinone preparation technology, and provides a high-yield cycloazinone synthesis process, including the following steps: Step 1: N-ethoxycarbonyl-N,N,N-trimethylguanidine and a solid-phase catalyst are added to toluene and stirred evenly. Under nitrogen protection, the temperature is raised to 40-60°C, and a cyclohexyl isocyanate toluene solution is added dropwise. Stirring is continued for 2-4 hours. The solid-phase catalyst is recovered by filtration, and the mixture is concentrated under reduced pressure to obtain N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine; Step 2: Under nitrogen protection, the temperature is raised to 50-60°C, and the N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine toluene solution is added dropwise to a sodium methoxide toluene solution and stirred for 1-2 hours. The temperature is lowered to room temperature, and glacial acetic acid is added for neutralization. After washing, the mixture is concentrated under reduced pressure, and a crystallizing agent is added. The temperature is lowered to 0-5°C, and the mixture is stirred for crystallization for 2-4 hours. After filtration and washing, the mixture is dried under vacuum to obtain the finished cycloazinone.

The invention belongs to the technical field of chemical synthesis, and particularly relates to an indazole alkaloid derivative as well as a preparation method and application thereof. Comprising the following steps: under an alkaline condition, carrying out alkylation reaction on a compound a and an alkylating agent to obtain a compound b; performing demethylation reaction on the compound b and a demethylation reagent to obtain a compound c; carrying out glycosylation reaction on the compound c and sugar bromide to obtain a compound d; in a sodium methoxide and solvent system, removing acetyl on glycosyl of the compound d to obtain the indazole alkaloid derivative. Or carrying out oxidation reaction on the compound d and methyl iodide to obtain an intermediate; and removing acetyl on glycosyl of the intermediate in a sodium methoxide and solvent system to obtain the indazole alkaloid derivative. The invention provides a preparation method of an indazole alkaloid derivative, which is green, simple, convenient and efficient.

The utility model relates to sodium methoxide preparation technology field of alkali method, proposes a kind of production equipment for sodium methoxide preparation of alkali method, including support frame, the right lower end inner wall of support frame is installed connection has positive and negative motor, and the output of positive and negative motor is connected with the middle shaft installation of driving gear, the lower end of blanking is connected with cooling structure by mechanical seal, electric telescopic handle is installed on the upper end inner wall of mounting bracket, cooling structure includes installation cylinder, cooling bar and cooling leaf, the upper end of elastic collection bag is integrally fixed connection with the lower end inner wall of inlet, the front and rear ends of roll pressure wheel are integrally fixed connection with adjusting gear. The production equipment for sodium methoxide preparation of alkali method, when producing preparation to sodium methoxide solution, improve the efficiency of sodium methoxide solution stirring dissolution, control the temperature inside reaction device stably simultaneously, avoid the occurrence of safety accident, improve the security of production.

The invention discloses a preparation method of 1-amino-2-cyano-1-cyclopentene, which comprises the following steps: 1, preparing a mixed solution, namely mixing a first organic solvent with super alkali in a protective gas atmosphere, heating by adopting a nano infrared energy-saving electric heating coil, stirring, uniformly mixing and dissolving to obtain the mixed solution; the super base is selected from one of potassium tert-butoxide, sodium tert-butoxide, sodium ethoxide, sodium methoxide and sodium hydroxide; 2, cyclization reaction: dropwise adding adiponitrile into the mixed solution, and continuously carrying out infrared heat preservation reaction for 3-8 hours to obtain a reaction solution of 1-amino-2-cyano-1-cyclopentene; 3, cooling crystallization and filtration: cooling the reaction liquid to-10-5 DEG C, standing for crystallization, and carrying out pressure filtration in a protective gas atmosphere to obtain an ACCP crude product and a filtrate; and 4, recrystallizing and refining to obtain a pure product. The method is mild in reaction condition, low in energy consumption, good in product yield and high in product purity, solves the problems of high solvent toxicity, low yield and high environmental protection pressure in the prior art, and is suitable for production of medicine and pesticide intermediates.

The invention discloses a bentazone intermediate sulfonation-chlorination two-step continuous preparation process which comprises the following steps: continuously metering and adding a solvent, chlorosulfonic acid, triethylamine, isopropylamine and a catalyst into a first-section tubular reactor, and carrying out sulfonation reaction to obtain a reaction material isopropylaminosulfonic acid; continuously introducing the reaction material isopropylamine sulfonic acid into a second section of tubular reactor, and simultaneously continuously metering and adding methyl anthranilate and phosphorus oxychloride for chlorination reaction; after the reaction is finished, quenching the reaction liquid with water, and carrying out layering and distillation treatment to obtain an intermediate o-isopropylamine sulfonamide methyl benzoate solid; and carrying out ring-closure reaction on the intermediate o-isopropylamino sulfonamido methyl benzoate solid and sodium methoxide in a methanol solution to prepare the bentazone active compound. According to the method, the defects of low bentazone product content and poor yield caused by high temperature of intermittent sulfonation and chlorination are effectively overcome, the operation time is shortened, and the productivity is improved.

The invention discloses a purification process of hexazinone production wastewater, and relates to the technical field of wastewater treatment. The process comprises the following steps: introducing wastewater of a hexazinone production process into an enamel microfiltration reactor for reaction, and filtering out pretreated wastewater; the pretreated wastewater is pumped into a graphite condensation type oxidation tower, a composite catalyst composed of a sodium methoxide methanol solution and methyl chloroformate is added for a reaction, and oxygenated wastewater is obtained; adjusting the pH value of the wastewater subjected to oxygen catalysis to 7.0-7.5, introducing the wastewater into a biological denitrification reaction tank, and adding a microbial agent compounded by nitrifying bacteria and denitrifying bacteria for reaction to obtain purified wastewater; refluxing 80% of the purified wastewater to a raw material preparation process for hexazinone production for reuse, and discharging the remaining 20% of the purified wastewater after being detected to be qualified; according to the invention, a grading process of pretreatment, catalytic oxidation, biological denitrification and reclaimed water reuse is designed, so that deep purification of high-ammonia-nitrogen COD wastewater is realized.

The utility model relates to an industrial wastewater treatment technology, and discloses a sodium methoxide wastewater purification system which comprises a sodium methoxide wastewater temporary storage tank, a filter, an adsorption purifier, a film evaporator and a three-stage separation system, the sodium methoxide wastewater temporary storage tank is connected with the filter, the filter is connected with the adsorption purifier, the adsorption purifier is connected with a solvent adjusting tank, and the film evaporator is connected with the solvent adjusting tank. The solvent adjusting tank is connected with the film evaporator; the film evaporator is connected with the three-stage separation system; the film evaporator comprises a vacuum film evaporator and a rotary scraper type film evaporator, the rotary scraper type film evaporator is connected with a condenser, the condenser is connected with a condensate recovery tank, and the condensate recovery tank is connected with a circulating material pipe; a horizontal spiral discharging centrifugal machine of the three-stage separation system is connected with a rotary scraper type film evaporator, the horizontal spiral discharging centrifugal machine is connected with a pressurizing leaf filter, the pressurizing leaf filter is connected with a vacuum belt filter, the vacuum belt filter is connected with a vacuum microwave dryer, and the vacuum microwave dryer is connected with a cooling tank.

The utility model relates to a waste heat recovery technical field, proposes a kind of waste heat recovery device of waste gas in sodium methoxide production process, including distillation column body: the one side of distillation column body is fixedly connected with two connecting pipes one, the other side of two the connecting pipe one is respectively fixedly connected with heat exchange tube one and heat exchange tube two, heat exchange tube one and heat exchange tube two between fixedly connected with connecting pipe three, the inside fixedly connected with water delivery valve of connecting pipe three, the one side fixedly connected with water inlet two of heat exchange tube two, the one side fixedly connected with water outlet of heat exchange tube one, since hot waste gas is discharged by distillation column body first into the inside of heat exchange tube one and heats, when reaching heat exchange tube two inside, it is the hot waste gas after cooling, at this time, by the cold water of water inlet two can make the hot waste gas after cooling more thorough cooling.

Provided is a method for producing a heterogeneous linear carbonate, including a step of performing transesterification of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst selected from one or more of lithium methoxide (LME), lithium ethoxide (LEE), sodium methoxide (SME), sodium hydroxide (NaOH), and a mixture thereof, the catalyst being introduced in a state of being dissolved in a sulfoxide-based solvent.

The application discloses a preparation method of 2-cyano-3-hydroxy-2-buten-(4-trifluoromethyl-phenyl)amide, which comprises the following steps: reacting a compound of formula (II) with acetyl chloride or acetic anhydride under the action of a base; wherein the base comprises sodium ethoxide and / or sodium methoxide. In the application, sodium hydride with a relatively high risk coefficient is replaced by sodium alcoholate, the operation difficulty is reduced, the yield is improved compared with sodium hydride, and the application is more suitable for industrial production.

The utility model discloses a wastewater treatment device for sodium methoxide production, and relates to the technical field of wastewater treatment. The device comprises a water storage part used for storing wastewater needing to be treated, a sludge scraping part mounted in the water storage part and capable of cleaning up sludge floating during wastewater filtration and guaranteeing effective filtration, and a stirring part arranged in the water storage part and capable of stirring the wastewater filtered by the sludge scraping part, so that the wastewater can be filtered by the sludge scraping part, and the stirring part is used for stirring the wastewater filtered by the sludge scraping part. The wastewater is fully mixed with a medicament for treating the wastewater, is preliminarily filtered by the sludge scraping part, and then enters the stirring part through the water storage part. According to the wastewater treatment device for sodium methoxide production, the sludge scraping part is arranged, so that the problems that in the use process of the conventional wastewater treatment device for sodium methoxide production, as time goes on, impurities in wastewater can block the filter plate, a channel for water to pass through the filter plate becomes smaller and even is partially blocked, the wastewater filtering speed is greatly reduced, and the progress of the whole wastewater treatment process becomes slow are solved.

The invention discloses a bridged ring phloroglucinol antibacterial compound as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry and anti-infection pharmacy. The structural general formula of the bridged ring phloroglucinol antibacterial compound is shown in the specification. The preparation method specifically comprises the following steps: (1) preparing a compound B by taking methyl iodide, sodium methoxide and a compound A as raw materials; (2) preparing a compound C by taking diisobutylaluminium hydride, the compound B, 2, 6-dimethyl pyridine and trifluoromethanesulfonic anhydride as raw materials; (3) preparing a compound D by taking palladium acetate, triphenylphosphine, the compound C, triethylamine and formic acid as raw materials; and (4) preparing a target product by taking the compound D, hexafluoroisopropanol, p-toluenesulfonic acid, the compound E, chiral phosphoric acid and ytterbium trifluoromethanesulfonate as raw materials. The compound disclosed by the invention shows high selectivity, low drug resistance risk and a potential new action mechanism, and provides a new leading structure and a technical path for overcoming drug resistance of existing antibacterial drugs.

The invention discloses a treatment method of a florfenicol by-product N, N-diethyl-2, 3, 3, 3-tetrafluoropropionamide, and belongs to the technical field of chemical engineering, the treatment method comprises a hydrolysis addition reaction and a cyclization reaction; the hydrolysis addition reaction comprises the following steps: mixing N, N-diethyl-2, 3, 3, 3-tetrafluoropropionamide with diethylamine and alkali liquor, and then carrying out hydrolysis reaction and addition reaction to obtain N, N, N ', N'-tetraethyl malonamide; the cyclization reaction comprises the following steps: mixing organic solvent solutions of N, N, N ', N'-tetraethyl malonamide and sodium methoxide, adding a mixed solution of formamidine and an organic solvent, carrying out reflux heat preservation reaction, evaporating materials to dryness, acidifying and filtering. According to the method, the malonamide intermediate is generated through fewer reaction steps, then the 4, 6-dihydroxypyrimidine is prepared, most of materials can be recycled, the atom economy is high, and the pollution to the environment and the post-treatment pressure are also reduced.

The application discloses a preparation method of 2-ethyl-2-methyl pentanoic acid, wherein in the process of preparing a key intermediate 2-cyanopentanoate (compound B), compound A is removed by using an alkali extraction method, high-purity compound B is separated by using rectification (a yield of 20% and a purity of 98%), and the operation process is simple. In the preparation method, reagents used are sodium methoxide, sodium hydroxide, sulfuric acid, sodium hydride and sodium nitrite, the reagents are simple, the danger is relatively small, and the experimental operation is relatively safe. In the preparation method, the post-treatment processes of alkylation, hydrolysis, deacidification and cyano hydrolysis do not use a chromatographic column purification process, and a conventional extraction distillation operation is adopted, so that the output of unit volume of instrument equipment is high.

The invention relates to the field of water treatment, and discloses a self-tracing type scale and corrosion inhibitor based on a novel fluorescent copolymer and a preparation method, and the scale and corrosion inhibitor comprises the following components: the novel fluorescent copolymer, an auxiliary polymer, a conventional AMPS copolymer, organic phosphonate, zinc salt and the balance of water. The novel fluorescent copolymer is obtained by carrying out copolymerization reaction on a fluorescent monomer B, acrylic acid and 2-acrylamido-2-methylpropanesulfonic acid; and the fluorescent monomer B is prepared by reacting 4-chloro-1, 8-naphthalic anhydride with 3-dimethylaminopropylamine, reacting the product with sodium methoxide, and further reacting the obtained intermediate with chloropropene. And the auxiliary polymer is a lauryl methacrylate-N, N-dimethylaminoethyl methacrylate copolymer. According to the self-tracing type scale and corrosion inhibitor, the fluorophore is covalently bonded to a polymer main chain, accurate online monitoring of the concentration of the agent is achieved, and the self-tracing type scale and corrosion inhibitor has excellent scale and corrosion inhibition performance.