2 results about "Thiamphenicol" patented technology

The utility model relates to a component detection device for an enteric-coated tablet, and aims to solve the technical problems that pollution is easily caused in the process of transferring the ground enteric-coated tablet at present, and thiamphenicol in the enteric-coated tablet is easily decomposed when being transferred and ground due to the fact that the thiamphenicol is easily decomposed when being exposed to light, so that the component detection result of the enteric-coated tablet is influenced. Comprising a grinding pipe, an extraction pipe, a filter pipe and a storage pipe, the grinding pipe, the extraction pipe, the filter pipe and the storage pipe are sequentially connected from top to bottom, the top of the grinding pipe is connected with a cover plate through a bolt, a driving motor is installed on the cover plate, a grinding mechanism is arranged in the grinding pipe and connected with the driving end of the driving motor, and the driving end of the driving motor is connected with the extraction pipe. According to the utility model, the grinding, extracting and filtering of the enteric-coated tablet can be continuously completed in a sealed space, and the treated sample does not need to be transferred, so that the influence on the component detection result of the enteric-coated tablet caused by pollution and photolysis of thiamphenicol in the enteric-coated tablet in the transferring process is avoided.

This invention relates to a chiral method for preparing thiamphenicol. Specifically, the method uses p-methylsulfonylbenzaldehyde and glycine ester as starting materials, and carries out an asymmetric aldol reaction in the presence of a pyridinium salt carbonyl catalyst, followed by a reduction and amidation reaction to obtain thiamphenicol. This invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starts with inexpensive and readily available raw materials, reduces the steps of introducing and removing protecting groups, shortens the synthetic route, and efficiently synthesizes optically pure thiamphenicol. Furthermore, the preparation method of this invention is simple to operate and environmentally friendly.