37results about How to "High efficiency and low toxicity" patented technology

A curcumin medicine for preventing and treating cancer and cardiovascular and cerebrovascular disease includes a pre-concentrated curcumin liquid in the form of softgel and prepared from the precursor of curcumin and emulsifier and a fatty curcumin emulsion prepared from the precursor of curcumin, emulsifier, antioxidant, isotonic regulator, stabilizer, pH regulator, and the water for injection. It can also provide energy to the patient.

The invention discloses a flame-retardant composite material with DOPO (9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) modified nano mesoporous molecular sieve, belongs to the fields of nano mesoporous molecular sieve flame-retardant synergists and halogen-free flame-retardant composite materials, and particularly relates to the preparation method of the DOPO modified nano mesoporous molecular sieve and the flame-retardant composite material with the DOPO modified nano mesoporous molecular sieve. The DOPO is of a hexahydric phosphorus-heterocyclic-ring structure, and is a novel flame retardant intermediate. The nano mesoporous molecular sieve is the flame-retardant synergist. The invention discloses the method for preparing the DOPO modified nano mesoporous molecular sieve and the flame-retardant composite material with the DOPO modified nano mesoporous molecular sieve. Since the compound flame-retardant synergist plays a role in phosphorus / silicon synergistic flame retardance, the obtained product has good expandable carbon forming property, the flame-retardant efficiency of the material is obviously increased, the remaining amount of the residual carbon and the compact degree of a carbon layer are increased, and further the flame redardancy of the composite material is improved to a greater degree.

A tree-type polyamide-amine material series includes G1.5, G2.0, G2.5, G3.5...G8.0 three-type high-molecular materials. The above-mentioned half generation tree-type polyamid-amine material is prepared through Michael addition reaction of integer generation one on methyl acrylate under the catalysis of sodium methoxide. The above-mentioned integer generation tree-type polyamide-amine material is prepared through amidation reaction of half generation one on ethanediamine. Its advantages are biodegradability and low poison. It can be used as gene transfer carrier and release controlling carrierof medicine.

The invention discloses nanoparticles of an antibody chemotherapeutic drug such as doxorubicin and maytansine (DOX, DM1) based on an antibody conjugation new technology and a preparation method and an application thereof. Experimental results show that compared with a single antibody and a single drug, nanoparticles formed by self-assembling antibody-chemotherapeutic drug conjugated conjugates has a targeting property significantly enhanced, and has the drug toxic and side effects on bodies significantly reduced; the formed nanoparticles use enhanced permeability and retention effect (EPR) of tumor tissues in a composite mode to enhance intratumoral accumulation, enhances the bioavailability of the drug, at the same time, reduces the use dosage of the drug, and provides a high-efficiency and low-toxicity nano treatment mode for tumor targeted therapy.

The invention discloses a platinum complex for inhibiting cell SKOV3 and a synthesis method of the platinum complex, belongs to the technical field of medicines, and aims to provide a cell SKOV3 inhibiting platinum complex synthesized from rutaecarpine as structural basis and DMSO as an auxiliary ligand. The invention further provides a synthesis method of the platinum complex. The structural formula of the platinum complex is as shown in the description. The platinum complex can be used for preparing anti-tumor drugs.

The invention discloses compound seed coating agent and the preparation method thereof. The compound seed coating agent is manufactured with 5 to 10 kg of carbosulfan, 10 to 15kg of fernasan, 0.4 to 1kg of tebuconazole, 5 to 10kg of film former, 1 to 5kg of bentonite, 1 to 5kg of thickener, 1 to 5kg of emulsifier, 0.2 to 1kg of rhodamine, 1 to 5kg of antifreeze and 40 to 80kg of water. The invention has the characteristics of high efficiency and low toxicity. The toxicity of the invention is 20 to 30 times lower than that of the seed coating agent made from the carbofuran and thimet etc.; due to the mixture of the fernasan and tebuconazole, the sterilizing effect of the seed coating agent on the head smut in maize is 8 times higher than that of the single bactericide.

The invention discloses a preparation method of a solid dispersant and application. The preparation method is characterized in that fucoidin with low molecular weight and PEG (polyethylene glycol) with molecular weight of 4000 to 10000 are used as combined dispersing mediums, curcumin is used as a dispersing substance, and a grinding method is adopted, so as to prepare the solid dispersion. Compared with the solid dispersion single using PEG6000 or curcumin, the solid dispersion has the advantages that the solubilization effect is better; the fucoidin and curcumin compound preparation is usedfor preventing and treating the helicobacter pylori infection and protecting the gastric mucosa; particularly, on the basis of anti-sticking property and immunity-regulating function of the fucoidin,and the anti-oxidizing and inflammation-diminishing functions of the fucoidin and the curcumin, the greater prospect is realized on overcoming the drug resistance of helicobacter pylori, and preventing and treating the infection of helicobacter pylori; the solid dispersion can be further prepared into the fucoidin and curcumin compound preparation, such as powders, tablets, capsules, granules or dry-mix suspenions.

The invention discloses usage of fludioxonil and antiseptic compound thereof in preventing and treating diseases of sweet potato during storage, wherein the diseases includes sweet-potato rot and ulcer disease, sweet-potato soft-rot disease, sweet-potato melasma disease, sweet-potato tar-spot disease and the like. The antiseptic compound comprises the following active ingredients: fludioxonil and active component B, wherein mass ratio of the fludioxonil to the active component B is (1-10): (10-1); and the active component B is prochloraz or difenoconazole. The fludioxonil and the antiseptic compound containing the fludioxonil can be prepared into pesticides of regular dosage forms. The fludioxonil and the compound thereof disclosed by the invention are high in drug efficacies to diseases of sweet potato during storage and good in disease preventing and treating effects; moreover, the fludioxonil and the compound thereof have wide bactericidal spectrums, so that the fludioxonil and the compound thereof are good in preventing and treating effects to the sweet-potato rot and ulcer disease, sweet-potato soft-rot disease, sweet-potato melasma disease and sweet-potato tar-spot disease. Furthermore, the fludioxonil, the prochloraz or the difenoconazole have the characteristics of high efficacy and low toxicity, so that the compound has good safety. The fludioxonil and the antiseptic compound thereof have the advantages of low cost, simple method and so on.

The invention relates to a medicine for treating type 2 diabetes and obesity, in particular to an application of three bromophenol compounds to the preparation of the medicine for treating type 2 diabetes and obesity. The bromophenol compounds of the invention have inhibitory activity against protein tyrosine phosphatase (PTP1B), and can be used for treating the type 2 diabetes and the obesity.

The invention relates to a gambogic acid colon-specific controlled release tablet and a preparation method thereof. The colon-specific controlled release tablet comprises a tablet core and a coating layer; the tablet core comprises the following material in percentage by weight: 1 to 60 percent of gambogic acid, 2 to 95 percent of diluent adjuvant, 2 to 20 percent of disintegration adjuvant, 1 to 20 percent of adhesion adjuvant, and 0.1 to 5 percent of lubricating adjuvant; and the coating layer comprises the following material in percentage by weight: 15 to 80 percent of polysaccharide compound, 15 to 80 percent of adhesion adjuvant, and 0.2 to 5 percent of lubricating adjuvant. The polysaccharide compound of the coating layer preferably adopts one of pectin and konjac glucomannan. The preparation method comprises the steps of tablet core preparation and coating layer preparation. The gambogic acid colon-specific controlled release tablet can accurately transfer drug to colon, improves the treatment effect of colon cancer, reduces the side effect, and improves the compliance of patients.

The present invention relates to the new medical use of paeonol, in particular to the new medical use of paeonol as a radiation sensitizer. Surprisingly, the present invention finds that paeonol has the effect of increasing the radiosensitivity of tumor cells, has obvious in vivo and external radiosensitization effects on Lewis lung cancer, and has the effect on lung A-549 cells, glioma C6 cells, and esophageal cancer cells. ECA-109 cells have broad-spectrum radiation sensitization. Compared with the existing radiosensitizers, paeonol has the characteristics of high efficiency and low toxicity, and it is expected to become a safe and effective new drug for radiosensitization.

The invention relates to a degradation fragment composite of ribonucleic acid, consisting of a plurality of artificial degradation fragments of ribonucleic acid separated and purified from bowels of pigs. The quantity of nucleotide in the artificial degradation fragment of ribonucleic acid ranges from 10 to 300 and the molecular weight ranges from 2*10<2> to 6*10<4>. The invention also relates to the application of the degradation fragment composite of ribonucleic acid in preparation of the medicine for treating polygenic diseases such as liver cancer.

The invention discloses cation amino lipid and a synthesis method and application thereof. Structure of cation amino lipid is shown as follows. The synthesis method is mild in synthesis reaction condition and high in solvent selectivity, reaction difficulty is lowered greatly, and yield is increased; raw materials are simple and cheap, so that production cost is lowered greatly; more importantly, lipid molecules obtained through screening have the characteristics of high efficiency and low toxicity and can realize good effect in blood serum, so that operation steps of transfection are simplified greatly.

The invention discloses a bio-based solvent-resistant plasticizer and a preparation method thereof. The bio-based solvent-resistant plasticizer is formed by combining modified isosorbide dioleate, tri (ethyl butyrate) isocyanurate and tetrabutylammonium chloride. The components of the bio-based solvent-resistant plasticizer prepared by the invention cooperate with one another, so that the bio-based solvent-resistant plasticizer not only has a good plasticizing effect, but also can improve the flexibility, tensile strength, extraction resistance and degradability of polyethylene resin and endow polyethylene with good flame retardant property, and meanwhile, the preparation raw materials are green and environment-friendly and have good biocompatibility.

The invention belongs to the pharmaceutical biotechnology field, in particular relates to gene cloning, expression of an exogenous gene in a procaryotic cell, purification of target protein, and novel tumor necrosis factor fusion protein of tumor blood vessel targeted peptide. The invention is characterized in that a small bacteriophage peptide capable of being specifically combined with a blood vessel with gastric cancer is obtained by applying a bacteriophage peptide library in vivo screening technology, and is fused into Escherichia coli together with a novel human tumor necrosis factor alpha (rmhTNF) to obtain high-level expression, the target protein is purified by ammonium sulfate salting-out or an anion-cation exchange method, and the obtained target protein is subject to an activity test. The target protein has the advantages of high efficiency and low toxicity of a novel recombinant human tumor necrosis factor, and can gather in a new blood vessel of a gastric cancer tissue, thus further lowering the clinical dosage for the human tumor necrosis factor, improving the dosage-effect ratio and lowering the toxic and side effect during gastric cancer treatment.

The invention provides application of a berberine and bacillus licheniformis composition in preparation of a drug for preventing or treating diseases caused rotavirus infection and relates to the field of drug compositions and novel application thereof. The berberine and bacillus licheniformis composition is used for preventing or treating enteritis, diarrhea and other diseases caused by rotavirus infection and has the advantages of being efficient, low in toxicity and the like.

The invention discloses a sesame seed treatment agent including the following components in parts by mass: 10-20 parts of a bactericide, 5-10 parts of an insecticide, 6-9 parts of a nutrient element, 3-5 parts of a hormone, and the balance water; the bactericide includes bitter herbs, aloe and sophora alopecuroides, the insecticide includes sabina vulgaris ant, radix sophorae flavescentis, artemisia annua and african marigold, the nutrient element includes a mixture of potassium dihydrogen phosphate and boron, and the hormone is a rooting powder. The bactericide, the insecticide, the plant growth regulator, the nutrient element and other components are compounded to form the seed treatment agent meeting the requirements of sesame seed germination; the treatment agent is beneficial for reducing and effectively controlling diseases and insect pests at the sesame seedling period, provides required nutrients for sesame germination, regulates sesame growth development and surrounding water, oxygen and other environmental conditions, and realizes the sesame seed production standardization. The treatment agent can prevent birds and diseases and control pests, also can appropriately supplement plant nutrients and growth hormones, is more conducive to sesame full seedling and good seedling emergence, has the advantages of high efficiency and low toxicity, multiple efficacies with one-time treatment, low cost and environmental friendliness, greatly reduces the cost of production of sesame, and lays a foundation for high-yield high-efficiency simplification of sesame production.

The invention relates to the technical field of plant protection, in particular to a control method for tsaoko anthracnose. The prevention and treatment method for the tsaoko anthracnose comprises the following steps: S1, land selection and garden cleaning: selecting a land parcel without epidemic situation and insect attack outbreak, and disinfecting soil with 50% carbendazim; s2, seed treatment: selecting a disease-resistant variety, performing seed treatment before sowing, and soaking the seeds in warm water at 50 DEG C for 30 minutes; s3, cultivation management: increasing the shading degree, improving the ventilation condition and reducing the humidity of the cultivation area; in the seedling stage and the vigorous growth stage of the amomum tsao-ko, spraying Difengtian dew or medium trace element leaf fertilizer; in the earlier stage of flowering and after harvesting, fully decomposed organic fertilizer is applied, diseased shoots are cut off in time, and diseased fruits are removed in time. According to the method for preventing and treating the anthracnose of the Amomum tsao-ko, the occurrence of the anthracnose of the Amomum tsao-ko can be effectively controlled, agricultural measure links such as land selection and garden cleaning, seed treatment, cultivation management and the like are emphasized, and the harm of the anthracnose of the Amomum tsao-ko is scientifically solved in cooperation with spraying of a novel chemical agent.

The present invention relates to hepatitis treating medicine composition, and especially hepatitis treating lovir medicine composition. The lovir medicine composition contains lovir compound in 10-50 weight portions and Chinese medicine component matrine in 10-50 weight portions. The lovir compound and the matrine component result in excellent synergistic antiviral effect and less side effects, so that the lovir medicine composition has raised curative effect and lowered toxicity.

The invention discloses a dispersable solid preparation for preservation and fresh keeping of fruits as well as a preparation method and application of the dispersable solid preparation. The dispersable solid preparation for preservation and fresh keeping of fruits consists of the following components in percentage by weight of 0.1-50% of 1-methylcyclopropene microcapsule granules, 0.1-50% of prochloraz, 1-10% of a dispersant, 1-6% of a moistening agent and the balance of a solid carrier, wherein the dispersable solid preparation can be moistening powder and water dispersible granules. The dispersable solid preparation can be in contact with fruits after being blended with water, the treatment time is only about 1min, and the treatment time and the treatment requirements are reduced. The dispersable solid preparation is free from an organic solvent, is few in drug residues, has the advantages of being high in efficiency, low in toxins, low in residues and consistent in environment, hasthe fresh-keeping effects of restraining diseases and ethene, can reduce the maturity and rate degree of the fruits, and can overcome the defects that in the prior art, a preservation and fresh keeping agent for fruits is long in treatment time, strong in smell, and has toxins and drug residues.

The invention relates to an anti-gout broadleaf holly leaf preparation and a preparation method and application thereof. The broadleaf holly leaf is fragrant with a bitter taste, and then sweet and cool, and has the effects of clearing heat and relieving summer heat, improving eyesight and intelligence, achieving dieresis and strengthening the heart, wetting the whistle and relieving a cough, lowering blood pressure and losing weight, resisting and preventing cancer, resisting aging and activating blood circulation and can also be used for treating gout diseases. Oral administration and injection of an extract have an obvious effect on a hyperuricemia model of mice caused by sodium urate, and are close to a positive control group of allopurinol. The anti-gout broadleaf holly leaf preparation has small toxic and side effects due to the fact that the anti-gout broadleaf holly leaf is homologous in drugs and food. At the same time, the preparation has cardiovascular and cerebrovascular protection and anti-inflammatory effects, and is an ideal anti-gout drug.

The invention belongs to the field of pharmaceutical preparations and relates to a brain-targeted nano system, in particular to a hydrogen sulfide controlled-release brain-targeted nano system for protecting a nervous system after a sudden cardiac arrest and a preparation method thereof. The nano system uses mesoporous iron oxide nanoparticles as a core to encapsulate a hydrogen sulfide donor drug, brain-targeted group lactoferrin is modified on surfaces of particles in a bifunctional PEG bridging mode, a low-toxicity hydrogen sulfide controlled-release brain-targeted nano system (DATS(at)MION-PEG-LF) is constructed, and a drug is delivered to the brain in a targeted mode and slowly released to maintain a treatment effect. The mesoporous iron oxide nanoparticles of the nano system can avoid a mononuclear phagocytosis system and keep stable for a long time in systemic circulation; and the assembled lactoferrin can be combined with lactoferrin receptors massively distributed on surfaces of brain capillary endothelial cells, such that receptor-mediated brain-targeted transport is realized. The nanoparticles have good safety and low cytotoxicity, can play a role in protecting a nervous system in a high-efficiency and low-toxicity manner, and have high clinical use and transformation values.

A tree-type polyamide-amine material series includes G1.5, G2.0, G2.5, G3.5...G8.0 three-type high-molecular materials. The above-mentioned half generation tree-type polyamid-amine material is prepared through Michael addition reaction of integer generation one on methyl acrylate under the catalysis of sodium methoxide. The above-mentioned integer generation tree-type polyamide-amine material is prepared through amidation reaction of half generation one on ethanediamine. Its advantages are biodegradability and low poison. It can be used as gene transfer carrier and release controlling carrier of medicine.

The invention discloses a preservative for sesame seeds, which includes the following components, by mass, 10-20 parts of a sterilizing agent, 5-10 parts of a pesticide, 6-9 parts of a natural preservative, 3-5 parts of hormone and the balanced being water. In the invention, the sterilizing agent, pesticide, plant growth regulator and various elements are compounded to form a seed processing agent satisfying the demand of germination of sesame seeds. The preservative can effectively reduce and control the diseases and pests of the sesame in seedling stage, provides required nutrient elements for the germination of sesame, regulates growth and surrounding conditions such as water, oxygen and the like of the sesame, and achieves production standardization of sesame seeds, can not only prevent birds and pests and diseases but also supply nutrients and growth hormones for plants properly, is more beneficial to completeness and tidiness of sesame seedlings, is high in effective and low in toxicity, is multifunctional, is low in cost and is environment-friendly, greatly reduces the production cost on sesame and provides basis for high-yield and high-effectively production of the sesame.

The present invention relates to hepatitis treating medicine composition, and especially hepatitis treating lovir medicine composition. The lovir medicine composition contains lovir compound in 10-50 weight portions and Chinese medicine component matrine in 10-50 weight portions. The lovir compound and the matrine component result in excellent synergistic antiviral effect and less side effects, so that the lovir medicine composition has raised curative effect and lowered toxicity.

The invention discloses a preparation method of a solid dispersant and application. The preparation method is characterized in that fucoidin with low molecular weight and PEG (polyethylene glycol) with molecular weight of 4000 to 10000 are used as combined dispersing mediums, curcumin is used as a dispersing substance, and a grinding method is adopted, so as to prepare the solid dispersion. Compared with the solid dispersion single using PEG6000 or curcumin, the solid dispersion has the advantages that the solubilization effect is better; the fucoidin and curcumin compound preparation is usedfor preventing and treating the helicobacter pylori infection and protecting the gastric mucosa; particularly, on the basis of anti-sticking property and immunity-regulating function of the fucoidin,and the anti-oxidizing and inflammation-diminishing functions of the fucoidin and the curcumin, the greater prospect is realized on overcoming the drug resistance of helicobacter pylori, and preventing and treating the infection of helicobacter pylori; the solid dispersion can be further prepared into the fucoidin and curcumin compound preparation, such as powders, tablets, capsules, granules or dry-mix suspenions.

The invention discloses a bactericide for controlling fruit tree rotten diseases and a preparation method and an application method of the bactericide for controlling the fruit tree rotten diseases. The bactericide comprises 1 part of main agent and 9-10 parts of adhesion agent playing a role in adhesion, wherein the main agent comprises, by mass, 5,000-8,000 parts of Folium Mahoniae, 3,000-4,000 parts of Radix Folium seu Flos Tripterygii Wilfordii, 3,000-4,000 parts of Radix Paeoniae Alba, 3,000-4,000 parts of Fructus Xanthii, 1,500-2,000 parts of Folium Ilicis Purpureae and 1-1.1 parts of 93% NAA, and the adhesion agent comprises 16 parts of rosin, 2 parts of animal oil, 6 parts of 95% alcohol and 1 part of turpentine. The application method of the bactericide includes scraping off diseased tissues thoroughly, scraping off 0.5-1 cm of good skin around the diseased tissues, scraping diseased spots to be fusiform, keeping the scraped surfaces smooth and applying the diseased parts with the bactericide directly, wherein the applying range exceeds the edges of scabs by 5-8 cm.

The invention relates to a medicine for treating type 2 diabetes and obesity, in particular to an application of three bromophenol compounds to the preparation of the medicine for treating type 2 diabetes and obesity. The bromophenol compounds of the invention have inhibitory activity against protein tyrosine phosphatase (PTP1B), and can be used for treating the type 2 diabetes and the obesity.

The invention relates to a preparation method of a microbial prepration for purifying a water body, which comprises the steps of separating purifying strains from the water body, screening two strainsfrom the obtained strains and respectively inoculating the two strains into a broth liquid culture medium for culture for 10-24h under the conditions for preparing bacterial suspension with the bacterial concentration of about 10<8>.ml<-1>, and mixing the two types of bacterial suspension for obtaining the microbial prepration with the bacterial concentration of about 10<8>.ml<-1>. The product ischaracterized by good flocculation and bleaching effect, rapid speed, high removal rate of COD, soluble phosphorus, ammonia nitrogen and nitrate nitrogen in water and the like; furthermore, the prepration cost is low, the use is convenient, and the preparation method can be widely applied in bioremediation of rivers, reservoirs, ponds, lakes and other waste water.