The invention discloses a sesame seed treatment agent including the following components in parts by mass: 10-20 parts of a bactericide, 5-10 parts of an insecticide, 6-9 parts of a nutrient element, 3-5 parts of a hormone, and the balance water; the bactericide includes bitter herbs, aloe and sophora alopecuroides, the insecticide includes sabina vulgaris ant, radix sophorae flavescentis, artemisia annua and african marigold, the nutrient element includes a mixture of potassium dihydrogen phosphate and boron, and the hormone is a rooting powder. The bactericide, the insecticide, the plant growth regulator, the nutrient element and other components are compounded to form the seed treatment agent meeting the requirements of sesame seed germination; the treatment agent is beneficial for reducing and effectively controlling diseases and insect pests at the sesame seedling period, provides required nutrients for sesame germination, regulates sesame growth development and surrounding water, oxygen and other environmental conditions, and realizes the sesame seed production standardization. The treatment agent can prevent birds and diseases and control pests, also can appropriately supplement plant nutrients and growth hormones, is more conducive to sesame full seedling and good seedling emergence, has the advantages of high efficiency and low toxicity, multiple efficacies with one-time treatment, low cost and environmental friendliness, greatly reduces the cost of production of sesame, and lays a foundation for high-yield high-efficiency simplification of sesame production.