Platinum complex for inhibiting cell SKOV3 and synthesis method of platinum complex

A technology of platinum complexes and synthesis methods, which is applied in the field of medicine, can solve the problems of lack of hyperconjugated planar large π bond systems, unfavorable metal complexes, etc., and achieve good medicinal value, high-efficiency anti-tumor activity, and easy synthesis.

Active Publication Date: 2017-12-22
YULIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effective component of Evodia rutaecarpa Evodiae has well-coordinated nitrogen and oxygen atoms in its structure, but it lacks a hyperconjugated planar large π bond system, which is not conducive to chelating with metal ions to form metal complexes from the structure. Although some derivatives of Evodia rutaecarpa have been developed as anti-tumor drugs, the research on complexes of evodiamine and platinum has not been reported, and there are almost no reports on other metal complexes of evodiamine.

Method used

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  • Platinum complex for inhibiting cell SKOV3 and synthesis method of platinum complex
  • Platinum complex for inhibiting cell SKOV3 and synthesis method of platinum complex
  • Platinum complex for inhibiting cell SKOV3 and synthesis method of platinum complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh evodiamine (0.029g, 0.1mmol), Pt(DMSO) 2 Cl 2 (0.060g, 0.15mmol), respectively dissolved in 5ml of chloroform and 5ml of methanol, mixed and placed in a 50ml round bottom flask, reacted for 3 hours under the condition of heating in a water bath at 55°C to make it completely reacted. Filtrate, volatilize at room temperature to obtain dark brown massive crystals, wash with petroleum ether and chloroform, and dry to obtain evodiamine platinum complex with a yield of 81.1%.

[0025] Product detection: carry out infrared spectrum and X-ray single crystal diffraction analysis to above-mentioned obtained dark brown solid product respectively, as Figure 1~2 shown; where figure 1 It is the infrared spectrogram of the platinum complex of the present invention; figure 2 It is an X-ray single crystal diffraction structure diagram of the platinum complex of the present invention.

[0026] figure 1 Specific spectral features are as follows:

[0027] IR spectrum: 3317, 1...

Embodiment 2

[0052] Weigh evodiamine (2.9g, 10mmol), Pt(DMSO) 2 Cl 2 (6.0g, 15mmol), respectively dissolved in 250ml of chloroform and 250ml of methanol, mixed and placed in a 1000ml round bottom flask, reacted for 3 hours under the condition of heating in a water bath at 55°C to make it completely reacted. Filtrate, volatilize at room temperature to obtain dark brown massive crystals, wash with petroleum ether and chloroform, and dry to obtain evodiamine platinum complex with a yield of 79.4%.

[0053] The product detection method is the same as in Example 1.

Embodiment 3

[0055] Weigh evodiamine (2.9g, 10mmol), Pt(DMSO) 2 Cl 2 (6.0g, 15mmol), respectively dissolved in 250ml of chloroform and 250ml of methanol, mixed and placed in a 1000ml round bottom flask, reacted under the condition of heating in a water bath at 65°C for 6 hours to make it completely reacted. Filtrate, volatilize at room temperature to obtain dark brown massive crystals, wash with petroleum ether and chloroform, and dry to obtain evodiamine platinum complex with a yield of 81.4%.

[0056] The product detection method is the same as in Example 1.

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Abstract

The invention discloses a platinum complex for inhibiting cell SKOV3 and a synthesis method of the platinum complex, belongs to the technical field of medicines, and aims to provide a cell SKOV3 inhibiting platinum complex synthesized from rutaecarpine as structural basis and DMSO as an auxiliary ligand. The invention further provides a synthesis method of the platinum complex. The structural formula of the platinum complex is as shown in the description. The platinum complex can be used for preparing anti-tumor drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a platinum complex for inhibiting SKOV3 cells and a synthesis method thereof. Background technique [0002] The present invention selects Rutaecarpine (Rutaecarpine), an active ingredient derived from the traditional Chinese medicine Evodia rutaecarpine, as a ligand to synthesize the platinum complex. Since the successful clinical use of cisplatin anti-tumor metal drugs, the research on platinum complexes has attracted more and more attention. However, due to the toxic side effects and drug resistance of platinum complexes, it has been found Platinum complexes with antitumor activity have always been a research hotspot in this field. The effective component of Evodia rutaecarpa Evodiae has well-coordinated nitrogen and oxygen atoms in its structure, but it lacks a hyperconjugated planar large π bond system, which is not conducive to chelating with metal ions to form metal compl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00
CPCC07F15/0093
Inventor 谭明雄申文英覃其品
Owner YULIN NORMAL UNIVERSITY
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