1301results about How to "Little side effects" patented technology

The invention provides a rectal cancer neoadjuvant chemoradiotherapy curative effect prediction method and system based on magnetic resonance image analysis, and aims to improve accurate prediction of curative effects of patients with local advanced rectal cancer (LARC). According to the method, multi-modal magnetic resonance images (T1WI, T2WI, DWI and DCE-MRI) are obtained, qualitative and quantitative analysis is combined, tumor morphology, diffusion characteristics and microcirculation parameters are extracted, clinical and pathological data of a patient are integrated, and a multi-dimensional feature set is constructed. Curative effect prediction is performed through machine learning and a deep learning model, and the model can predict treatment results of complete remission, partial remission, ineffectiveness and the like in a classified manner. The system accurately predicts the reaction of a patient to neoadjuvant radiotherapy and chemotherapy through a non-invasive method, supports formulation of a personalized treatment scheme, reduces excessive treatment, optimizes the treatment effect, and has good clinical application value.

The invention discloses a cranial nerve double-path stimulation intelligent regulation and control method and system for Parkinson's disease, and relates to the technical field of medical treatment and neural engineering, and the method comprises the steps: obtaining an electroneurographic signal of a target patient based on a stimulation electrode, and determining neural activity features according to the electroneurographic signal; the stimulating electrodes comprise a first stimulating electrode and a second stimulating electrode; determining a nerve evaluation value according to the nerve activity characteristics, and generating a co-stimulation parameter based on the nerve evaluation value; initial stimulation parameters of the stimulation electrode are adjusted based on the co-stimulation parameters, the target patient is stimulated through the stimulation electrode, and cranial nerve two-way stimulation intelligent regulation and control for the Parkinson's disease are completed. According to the invention, by introducing the abnormal oscillation mode and evaluating the synchronism characteristics of the neural network in real time, the neural activities of the deep brain and the vagus nerve area are comprehensively quantified, and the accuracy of nerve regulation and control is improved; by generating collaborative stimulation parameters and comprehensively considering the mutual influence of the two stimulation pathways, intelligent collaborative regulation and control are realized.

The invention discloses a vagus nerve stimulation parameter closed-loop adjustment method and system based on electroencephalogram characteristics. The method comprises the steps that real-time electroencephalogram signals of a patient are obtained, and time domain information and frequency domain information of the electroencephalogram signals of all frequency bands in the real-time electroencephalogram signals are extracted; on the basis of the time domain information and the frequency domain information of the electroencephalogram signals of all the frequency bands, electroencephalogram signal index features are calculated, and the electroencephalogram signal index features comprise an electroencephalogram signal power spectrum, a brain dynamic symmetry feature, a brain function connection feature and a rhythm feature; determining the state type of the patient according to the electroencephalogram signal index characteristics; determining parameter configuration information of vagus nerve stimulation according to the state type of the patient; and adjusting parameters of the vagus nerve electrical stimulation equipment according to the parameter configuration information of vagus nerve stimulation. According to the invention, timely and accurate electrical stimulation can be applied to a patient, the treatment accuracy is improved, the stimulation efficiency and the treatment effect are enhanced, side effects are reduced, and more accurate and individualized treatment management is realized.

The invention provides a chronic disease co-patient accurate medication real-time management system based on an AI large model, and the system comprises accurate medication guided by the AI large model, through the mathematical modeling and simulation technology, the related information of patients, medicines and diseases is integrated, and accurate medication is guided. According to the method, the administration scheme can be formulated more accurately, the curative effect is improved, side effects are reduced, a patient medication report is provided for physicians and pharmacists, the physicians and pharmacists can dynamically master patient medication information in real time, reference is provided for the physicians to formulate the next medication scheme, and the treatment effect on chronic disease patients is improved.

The invention discloses a Pickering emulsion with cinnamyl aldehyde as an oil phase and a preparation method of the Pickering emulsion. The Pickering emulsion is prepared by the following steps: carrying out a cross-linking reaction on anions released by sodium tripolyphosphate and protonated cations of chitosan to prepare chitosan nanoparticles as a water phase, and then taking cinnamyl aldehyde as an oil phase. The Pickering emulsion delivery system disclosed by the invention can effectively release cinnamyl aldehyde, shows the remarkable antibacterial property of cinnamyl aldehyde on a wound surface, promotes wound surface healing, and shows good treatment potential.

The invention relates to the technical field of aplastic anemia (AA) treatment research, discloses a biomarker method for predicting the curative effect of cyclosporine on aplastic anemia, and aims to detect plasma differential metabolites of patients with aplastic anemia by adopting a metabonomics technology, find potential biomarkers for treating AA patients and find the curative effect of cyclosporine on the AA patients. CsA) is used for treating the in-vivo metabolism of AA. The method is based on liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) technologies, and comprises the following steps: collecting 5 plasma samples of AA patients, 5 plasma samples of healthy people and 5 plasma samples of patients in a stable period after treatment for comparative analysis; and screening differential compounds by adopting a multivariate statistical method, and further performing enrichment analysis on differential metabolites. Research of the method shows that in-vivo metabolites of AA patients and healthy people are obviously different, and the way related to immunity and energy metabolism may be a key target for treating AA; csA intervenes the occurrence and development of AA by regulating and controlling immune-related metabolic ways.

The invention discloses a polymer drug-loaded particle for targeted adhesion to an intestinal inflammation area and a preparation method and application thereof.The method includes the steps that degradable polymer drug-loaded particles are subjected to surface modification through polycations and then added into a monomer solution of an adhesion layer, particle surface in-situ polymerization is initiated through ultraviolet irradiation, and a PAN adhesion layer is formed; the adhesion layer modified polymer drug-loaded particles are obtained. Wherein the polycation is used as a middle layer, so that the PAN adhesion layer can be successfully modified. Carboxyl in the adhesion layer enables the particles to present negative charges, meanwhile, succinimide ester can react with amino naturally existing on the surface of inflammatory intestinal tissue to generate an amide covalent bond, and finally targeted adhesion of the intestinal inflammation part is achieved. According to the adhesion strategy, the PAN can be effectively applied to the micro-nano-scale drug-loaded particles so as to enhance the adhesion of the micro-nano-scale drug-loaded particles in an intestinal tract damaged area, and a brand new thought is provided for treating inflammatory intestinal tracts.

The invention relates to the technical field of atherosclerosis related drugs, in particular to a macrophage membrane functionalized manganese dioxide nano-drug as well as a preparation method and application thereof in treatment of atherosclerosis. The invention relates to a macrophage membrane functionalized manganese dioxide nano-drug, which comprises an HMnO2 carrier, colchicine is loaded on the HMnO2 carrier, and a macrophage membrane is coated outside the HMnO2 carrier. The preparation can be applied to practical operation of preparing medicines for treating atherosclerosis. According to the technical scheme, the technical problem of limited treatment effect caused by single action mechanism of medicines for treating atherosclerosis in the prior art can be solved. The nano-drug in the scheme can remove ROS to play an anti-inflammatory effect, reprogram macrophages and promote cholesterol excretion, and is used for synergistically treating atherosclerosis. The macrophage membrane can target an inflammation part and escape from an immune system. And the side effect of the nano-drug is relatively small, so that the nano-drug has ideal popularization and application prospects.

The invention discloses a multi-metal borate nano-particle as well as a preparation method and application thereof. The preparation method comprises the following steps: in the presence of small molecules with alkyl chains, performing high-temperature thermal decomposition on an organic metal compound or a metal salt compound precursor and organic borate in a solvent, and then centrifuging, modifying, performing ultrafiltration, dialyzing and purifying to obtain the multi-metal borate nanoparticles. The preparation method disclosed by the invention has the characteristics of mildness, high efficiency and strong controllability. The multi-metal borate nanoparticles prepared by the preparation method disclosed by the invention have the advantages of monodisperse size, relatively high magnetic property and good biocompatibility. Therefore, the prepared multi-metal borate nanoparticles not only have multi-modal imaging functions such as magnetic resonance imaging, near-infrared two-region imaging, nuclear medicine imaging and magnetic particle imaging, but also can be used for various treatment means such as magnetocaloric therapy and boron neutron capture therapy; potential advantages are realized in biomedical applications such as magnetic targeting tumor treatment and imaging contrast agents, and high practical values are realized.

The invention discloses a polypeptide with binding affinity to IL-6 (interleukin-6) and application of the polypeptide. The amino acid sequence of the polypeptide comprises one or more of the sequences as shown in SEQ ID NO.1-6. The polypeptide compatible with IL-6 is obtained through screening, the polypeptide can be specifically compatible with IL-6, IL-6 is enriched, then IL-6 is adsorbed at an inflammation infection part, more choices are provided for absorption and removal of inflammatory factors and treatment of diseases related to too high IL-6, and the polypeptide can be used for IL-6 detection and preparation of drugs for targeted combination of IL-6 or treatment of Il-6 related diseases.

The invention discloses a gravitational field model-based lattice space segmentation radiotherapy lattice point optimization method, and relates to the technical field of radiotherapy. According to the method, by combining a PET-CT functional image, a key region, especially a hypoxic region (functional target region), of a tumor is recognized more accurately, and the positions and the distances of lattice points are dynamically adjusted according to biological characteristics of the tumor; arrangement of lattice points is dynamically adjusted through a gravitational field model, it can be guaranteed that a high-dose area accurately covers a key area of a tumor, unnecessary side effects can be reduced to the maximum extent, the risk of tumor recurrence is reduced, the method can better adapt to functional heterogeneity of the tumor, personalized treatment is achieved, and the method has good application prospects. And the influence on normal tissues is reduced while the treatment accuracy is improved, a more reliable treatment scheme is provided for treatment of complex tumors, and accurate dose distribution aiming at different tumor biological characteristics is realized.

The invention discloses a virtual screening method of candidate drugs. The virtual screening method comprises the following steps: 1) providing an FXR receptor; providing a TGR5 receptor; oCA with a modified structure is used as a lead compound; providing an FXR ligand small molecule; 2) according to an active pocket of the FXR, performing molecular docking scoring on the lead compounds and the FXR, and screening the lead compounds to obtain a first compound; 3) according to an active pocket of the TGR5 receptor, performing molecular docking scoring on each first compound and the TGR5 receptor, and screening out a second compound from the first compounds; and 4) screening the second compound by adopting a pharmacophore model constructed on the basis of FXR ligand small molecules. The method provided by the invention can effectively reduce blindness of traditional drug design experiments, has high efficiency and low cost, can greatly reduce the time required for improving the compound, and increases the success rate. The candidate drug can regulate lipid metabolism and has no side effect.

The invention relates to the technical field of medical recommendation, in particular to a personalized nutrition treatment knowledge base construction method and system for critical patients. The system is used for acquiring basic information, medical record information, laboratory examination data and period diet intake information corresponding to critical patients, performing critical case entity construction, and generating case entity descriptors of the critical patients; constructing a corresponding personalized nutrition treatment initial knowledge base for each critical patient case entity descriptor in combination with a semantic knowledge association ratio between related scientific research literatures; obtaining clinical pathological characteristics and nutrition treatment knowledge entities, performing nutrition demand analysis and administration opportunity determination, and performing nutrition administration effect conflict evaluation to obtain a clinical nutrition administration-diet effect conflict ratio; and performing nutrition treatment knowledge updating optimization on the personalized nutrition treatment initial knowledge base to generate a personalized nutrition treatment knowledge optimization base. Accurate nutrition support can be provided for critical patients.

The invention provides a lithium-supplementing composite additive, a lithium-supplementing positive pole piece for inhibiting flatulence and application, and belongs to the field of lithium ion batteries. The lithium supplementing composite additive is a mixture of a lithium supplementing agent and aminated aluminum oxide, the mass ratio of the lithium supplement agent to the aminated aluminum oxide is (6-10): (3-5); the aminated aluminum oxide is activated aluminum oxide modified by an amino organic matter; the mass ratio of the amino organic matter to the activated aluminum oxide is 3: (7-12); the lithium supplement agent is hydroxyl cycloenone dilithium salt or lithium carboxylate. The lithium-supplementing positive pole piece capable of inhibiting flatulence comprises a current collector, an active coating and a functional coating located on the surface of the active coating, and the functional coating contains a lithium-supplementing composite additive and has the functions of supplementing lithium, absorbing acid and inhibiting flatulence. The method is characterized in that the aminated alumina matrix can absorb hydrofluoric acid in an electrolyte, and the aminated group can absorb carbon dioxide generated by decomposition of a lithium supplement agent. The method can reduce the problem of battery cycle gas expansion in the use process of the lithium supplement agent, and improves the battery cycle and safety performance.

The invention discloses a Klebsiella phage and application thereof, and belongs to the technical field of life science. The Klebsiella bacteriophage is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.46000, the preservation date is July 22, 2024, and the Klebsiella bacteriophage is classified and named as FK9. The bacteriophage provided by the invention is a biological means capable of efficiently killing klebsiella pneumonia, has the characteristics of high efficiency, specificity and small side effect, achieves the effect of preventing and treating pneumonia caused by klebsiella pneumonia on the basis of not destroying in-vivo flora balance, is incomparable to antibiotics and other antibacterial drugs, and has a broad application prospect. And meanwhile, the method contributes to sustainable development of a health medical system.

The invention belongs to the technical field of micro-nano, and particularly relates to a drug-loaded microalgae motor and a preparation method and application thereof, and the drug-loaded microalgae motor comprises a polydopamine / ferroferric oxide / chlamydomonas reinhardtii micromotor and a drug loaded on the polydopamine / ferroferric oxide / chlamydomonas reinhardtii micromotor, the drug is combined with catechol groups on the surface of polydopamine in the polydopamine / ferroferric oxide / chlamydomonas reinhardtii micromotor through covalent bonds; the medicine is an anti-cancer medicine or an anti-inflammatory medicine. The microalgae motor has the characteristics of simple preparation method, good material biocompatibility, high biodegradability and the like. The polydopamine / ferroferric oxide / chlamydomonas reinhardtii drug-loaded micromotor prepared by the invention has the characteristic of self-driving in intestinal juice, so that the polydopamine / ferroferric oxide / chlamydomonas reinhardtii drug-loaded micromotor can target an intestinal disease part under the guidance of an external magnetic field to improve the treatment effect and reduce the side effect of a drug, thereby expanding the application space of a micro-nano motor in the field of biomedicine.

The invention relates to the technical field of medicine, and discloses an artificial exosome and application thereof in drug delivery, the artificial exosome is prepared into an oil phase based on PLGA and DOTAP, and a water phase based on OCT4 protein and siTrim28; mixing the two phases to obtain a primary emulsion, and adding a PVA aqueous solution to obtain a double emulsion; stirring the double emulsion and volatilizing the solvent to form an emulsified solution, and centrifuging to obtain PLGA nanoparticles; the lipid mixture is prepared from lipid, DPPE-PEG2000, alpha-tocopherol and alpha-lactalbumin, and a lipid film is formed after a solvent is evaporated; the preparation method comprises the following steps: mixing PLGA nanoparticles, a lipid film and membrane protein, uniformly mixing and heating to obtain a film-coated solution, and finally extruding through a cellulose acetate film to obtain the artificial exosome. The artificial exosome disclosed by the invention combines the stability of the PLGA nanoparticles and the biocompatibility of the lipid membrane, and provides new possibility for a drug delivery system.

The invention provides organic nanoparticles with high osteogenic performance as well as a preparation method and application thereof, and belongs to the technical field of osteogenic drug preparation. The preparation method of the organic nanoparticles with high osteogenic performance comprises the following steps: (1) preparing fluorinated polyethyleneimine, preparing double bonds from the fluorinated polyethyleneimine, and then grafting a targeting peptide E7 to obtain a carrier F-PEI-E7; and (2) entrapping an osteogenesis promoting drug in the carrier F-PEI-E7 to obtain the organic nanoparticles with high osteogenesis performance. The invention provides an innovative strategy: F-PEI is used as a carrier, an osteogenesis promoting drug (beta-GP) is entrapped, and through E7 targeting peptide (EPLQLKM) modification, precise targeting delivery of the drug is realized. The organic nanoparticles are high in stability, the in-vitro osteogenesis promoting effect is equivalent to that of a classical formula for in-vitro osteogenesis induction, and the organic nanoparticles have an excellent in-vivo osteogenesis promoting effect.

The invention provides mupirocin ointment as well as a preparation method and an application method thereof. The weight of mupirocin accounts for 0.1-0.5% of the total weight of the ointment. The water-soluble matrix is selected from polyethylene glycol, glycerol, propylene glycol or a mixture thereof. The stability and the curative effect of the medicine can be improved, and meanwhile, the safety and the use convenience of the ointment are ensured.

The invention relates to dithiolane modified beta-cyclodextrin, a preparation method thereof and application of the dithiolane modified beta-cyclodextrin as a drug carrier. The method comprises the following steps: carrying out acylation reaction on beta-cyclodextrin and lipoic acid, and modifying different numbers of dithiolane on the beta-cyclodextrin by changing a feeding ratio; the beta-cyclodextrin has a plurality of hydroxyl groups, and the activity of the hydroxyl groups at the C6 position is relatively high. The hydrophobic cavity of the dithiolane-modified beta-cyclodextrin can be loaded with a hydrophobic small-molecule drug, and the hydrophobic small-molecule drug can be loaded into the dithiolane-modified beta-cyclodextrin under the condition of heating reflux to form a nano-drug. The disulfide bond on the surface of the nano-drug and sulfydryl on protein or lipid on the outer side of a cell membrane are subjected to dynamic covalent thiol exchange, so that the nano-drug enters cells through a thiol-mediated cellular uptake way, endosomes and lysosomes can be avoided, the drug is quickly and directly delivered to the cytoplasm, degradation of the drug in the lysosomes is reduced, and the drug delivery efficiency is improved. The utilization rate of small-molecule drugs is improved, side effects are reduced, and better curative effects are achieved.

The invention discloses a range-limited light-operated anti-tumor composite hydrogel drug reservoir and a preparation method and application thereof.The light-responsive drug-loaded nano hydrogel is loaded into a temperature-sensitive hydrogel system to form the range-limited hydrogel drug reservoir with light-operated drug release, the preparation method comprises the steps that PEG, LA and GA are added into a three-necked flask for an oil bath reaction, and the temperature-sensitive hydrogel system is obtained; after the reaction, purifying and freeze-drying to obtain a PLGA-PEG-PLGA block copolymer; the PLGA-PEG-PLGA segmented copolymer is dissolved in ultrapure water, and a PLGA-PEG-PLGA sol is obtained; and dissolving the drug-loaded PDA (at) P (NIPAAm-co-AM) nano hydrogel into the PLGA-PEG-PLGA sol, so as to obtain the confined light-operated anti-tumor composite hydrogel drug reservoir. The confined light-operated anti-tumor composite hydrogel drug reservoir has light-responsive drug delivery performance, not only has space-time controllability of drug release, but also weakens the problems of photothermal effect and the like in light-assisted therapy, so that accurate tumor therapy can be realized.

The invention relates to a composition with brain strengthening and vision benefiting effects and application of the composition. The composition is prepared from the following components in parts by mass: 1 to 15 parts of DHA algae oil powder, 1 to 15 parts of walnut peptide, 0.1 to 0.5 part of lutein ester, 0.1 to 2 parts of tea leaf theanine, 4 to 30 parts of fructus lycii instant powder and 4 to 20 parts of blueberry fruit powder. The composition can be prepared into liquid beverage products, and can be brewed into cereal products, granules, capsules, tablets, powder, paste, pills, oral liquid and the like. The composition has the effects of strengthening the brain and benefiting vision, can effectively improve memory and visual fatigue symptoms and improve photopic vision persistence, and is simple, scientific, safe and reliable in product formula.

The invention discloses an application of a nano-drug and combined radiotherapy in cancer treatment, and relates to the technical field of nanotechnology and biomedicine. The nano-drug (GL) obtained by the simple preparation method is a gambogic acid loaded nano-liposome, and the GL has good biocompatibility and passive targeting property. According to the invention, GL and FLASH radiotherapy are combined to treat cancers, and through the synergistic effect of GL and FLASH radiotherapy, double striking on tumor cells is realized, so that the anti-tumor effect is remarkably enhanced, side effects in the treatment process are reduced, and the life quality of patients is improved. Besides, the combined treatment strategy effectively overcomes the problem that cancer is not sensitive to existing radiotherapy and chemotherapy, more remarkable and efficient anti-tumor effect is achieved, more treatment choices and hopes are brought to cancer patients, and a new way is opened up for cancer treatment.

The invention relates to a repetitive structural unit recombinant protein cpE2 and a preparation method and application thereof. The recombinant protein cpE2 of the repetitive structural unit has self-assembly performance and is formed by modifying an E2 subunit of a pyruvate dehydrogenase compound and dihydrofatty acid amide transacetylase. Specifically, the C end of the E2 protein is arranged at the N end through a connecting peptide by utilizing a circulating recombination principle, so that the recombinant protein cpE2 is constructed. The engineered cpE2 protein cage can be self-assembled into a cage-shaped structure, linking groups can be respectively brought into the protein cage through N-terminal or C-terminal modification of cpE2, the problem that a modifier or a drug is difficult to put into the protein cage by a traditional E2 protein is solved, meanwhile, the specific particle size of the cpE2 protein cage can be controlled through the length of a linking peptide, and the protein cage has a good application prospect. And efficient carrying of goods is achieved.

The invention discloses a Gegen Qinlian decoction vesicle-like nanoparticle as well as an extraction method and application thereof, and belongs to the technical field of biological medicines. The method comprises the following steps: preparing a radix puerariae qinlian decoction stock solution; placing at 4-8 DEG C for 12-15 hours to obtain a gelatinous substance; carrying out low-speed centrifugation at 4-8 DEG C, and taking supernate, so as to obtain crude extract of the vesicle-like nanoparticles of the radix puerariae, radix scutellariae and rhizoma coptidis decoction; carrying out ultracentrifugation at 4-8 DEG C, discarding the supernatant, and carrying out PBS resuspension precipitation to obtain a crude product of the vesicle-like nano-particles of the Gegen Qinlian decoction; and centrifuging 16000g at the temperature of 4-8 DEG C for 10-15 minutes, taking supernate, and filtering by using a 0.22 mu m filter membrane, so as to obtain the vesicle-like nanoparticles of the Gegen Qinlian decoction. According to the Gegen Qinlian decoction vesicle-like nanoparticles as well as the extraction method and the application thereof, the bioavailability and the targeting property of effective components in the Gegen Qinlian decoction are remarkably improved through a nanocrystallization technology, the concentration of the medicine at the ulcerative colitis part is enhanced, and the treatment effect is effectively improved.

The invention relates to the field of myopia prevention and control optical equipment, in particular to an optical lens with high-frequency disturbance information. Comprising a basic surface type area and a high-frequency control area; the center of the basic surface type area coincides with the center of the optical lens, the high-frequency control area is arranged on the peripheral side of the basic surface type area in a surrounding mode and comprises a plurality of high-frequency lens units, the high-frequency lens units are closely and adjacently arranged, and the surface type of each high-frequency lens unit is in at least one direction of the unit radial direction or the unit tangential direction. The surface type structure is provided with at least two height fluctuation periods. The micro-structure surface type in the high-frequency lens unit mainly acts on the retina by high-frequency disturbance, so that the side effect of low-frequency disturbance generated by a traditional spherical lens on the visual effect can be effectively reduced, and the visual quality is guaranteed. Meanwhile, the high-frequency lens unit has at least two height fluctuation periods in at least one direction; and continuously changing dynamic stimulation is provided for the retina, so that the adaptation speed of the retina is slowed down.

The invention relates to the technical field of beverage production processes, and discloses a production process of a vegetable beverage containing active organic iron extracted from brassica rapa leaf, and the production process comprises the following steps: S1, a raw material preparation stage, S2, a component extraction stage, S3, a filtration and concentration stage, S4, a preparation stage, and S5, a packaging stage. An iron supplement product is developed, iron of the iron supplement product is derived from natural active organic iron in the brassica rapa leaf raw material, and the iron in the form is more easily absorbed and utilized by a human body, so that the bioavailability of the iron is effectively improved, and side effects are reduced; compared with a traditional inorganic iron supplement, the prepared nutritional beverage can significantly reduce or avoid gastrointestinal discomfort and other side effects, so that the product is safer and suitable for long-term use.

The invention provides a model and a system for predicting the lifetime of a non-small cell lung cancer patient after radiotherapy. The system comprises an image processing module; a feature extraction module; the tumor radiomics model is trained on the basis of important tumor radiomics characteristics; the lung radiomics model is trained based on the important lung radiomics features; integrating a radiomics model, fusing the important tumor radiomics features and the important lung radiomics features, and screening out the most critical features; and finally fusing the model, and constructing and training to obtain a lifetime prediction model based on the most critical features and the clinical features. Tumor and lung radiomics characteristics and clinical parameters are integrated into the machine learning model and can be used for accurately predicting the overall lifetime of a lung cancer patient receiving radical radiotherapy, and the model is high in prediction precision, high in flooding ability and high in application value.

The invention discloses a gene engineering exosome and a slow release method and application thereof, the gene engineering exosome is derived from human adipose-derived stem cells, si-tgfbr2 is loaded in the gene engineering exosome, the si-tgfbr2 is specific siRNA aiming at a Tgfbr2 gene, and the gene engineering exosome can regulate and control proliferation of VSMCs, inhibit transformation of the VSMCs from a contraction phenotype to a synthetic phenotype when the VSMCs are stimulated, and inhibit the growth of the VSMCs. According to the present invention, the gene engineering exosome can be used to maintain the normal structure and the function of the blood vessel, and the sustained release effect of the content in the gene engineering exosome can be achieved by wrapping the gene engineering exosome in the PHA biodegradable material, such that the local treatment concentration can be easily stabilized, the drug administration frequency can be easily reduced, the lasting time of the treatment effect can be easily prolonged, and the treatment gene can be effectively delivered to the target cell; the treatment effect is improved; when being used for modifying a small-caliber artificial blood vessel, the small-caliber artificial blood vessel can be improved in biocompatibility and functionality, and can be prevented from being implanted into the blood vessel for remodeling unbenign hyperplasia stenosis; the invention not only provides a new thought and method for the treatment of vascular diseases, but also has important clinical application value and popularization prospect.

The invention discloses a polypeptide as well as preparation and application thereof, and belongs to the technical field of active peptides. According to the present invention, three active peptides are prepared from walnut meal protein, the amino acid sequences of the three polypeptides are respectively Leuu-Pro-Gln-Phe (LPQF), Leuu-Pro-Ser-Phe (LPSF) or Vla-Pro-Phe-Pro (VPFP), and the detection results show that the three polypeptides have inhibition activity on dipeptidyl peptidase-IV (DPP-IV), such that the three polypeptides can be used for preparing the blood sugar reducing drug.