96results about How to "Little side effects" patented technology

The invention provides a composition for treating nerve headache and a preparation method thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: carrying out steam explosion treatment on traditional Chinese medicine powder, adding the traditional Chinese medicine powder into saline water, decocting, filtering, standing filtrate to separate out a hydrochloric acid extract, adding filter residues into ethanol, adsorbing by a magnetic adsorbent, separating by a magnet, eluting, desorbing, recovering an eluent to obtain an alcohol extract, mixing and grinding the alcohol extract, the hydrochloric acid extract and flunarizine hydrochloride / nimodipine eutectic, and filling capsules with the alcohol extract and the flunarizine hydrochloride / nimodipine eutectic. The composition for treating the nerve headache is prepared. The traditional Chinese medicine composition treats neuropathic migraine through a method of combining traditional Chinese medicine and western medicine, treats both symptoms and root causes, and is good in effect and quick and lasting in effect.

This invention belongs to the field of traditional Chinese medicine technology, and provides a traditional Chinese medicine composition with the effects of clearing the throat and relieving cough, and its preparation method. The traditional Chinese medicine composition contains the following components: Scrophularia ningpoensis, Ophiopogon japonicus, Platycodon grandiflorus, Terminalia chebula, Mentha haplocalyx, Paeonia lactiflora, Glycyrrhiza uralensis, Borneol, and rice wine. This traditional Chinese medicine composition nourishes Yin and moistens dryness, cools the blood and reduces swelling, clears the throat and relieves cough, and can effectively improve symptoms such as sore throat, foreign body sensation in the throat, hoarseness, dry and itchy throat, and irritating dry cough caused by endotracheal intubation or gastric tube placement. This traditional Chinese medicine composition has definite efficacy, high safety, and few side effects, and has excellent clinical application and industrialization prospects.

The present application belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition and application thereof in preparation of an oral care product. The traditional Chinese medicine composition is prepared from 12-18 parts of Qingdai, 7-12 parts of raw gypsum, 7-12 parts of Huangqi, 9-15 parts of Gushugu, 3-7 parts of Honghuajiao, 3-7 parts of Baizhi, 6-10 parts of Fangfeng, 1-5 parts of Bajie, 6-10 parts of Huanylencao, 1-5 parts of Wuji, and 4-8 parts of Baiji as raw medicinal materials. The components of the composition are reasonably matched, and can realize multiple effects of analgesia, antibiosis, anti-inflammation, repair, and tooth fixation and health. The present application is suitable for all kinds of toothache patients, has a wide application range, a safe use mode, and a wide market application prospect.

This utility model relates to the field of atomization spray technology, specifically an atomization spray precision control device. The device includes an atomizer with a side-hollow structure. A baffle plate is located inside the atomizer, and a transmission groove is formed within the atomizer. A connecting rod is fixedly connected to the top of the baffle plate. The top of the connecting rod extends into the transmission groove and is fixedly connected to a gear. A threaded rod is rotatably connected inside the transmission groove. A sliding block is threadedly connected to the external thread of the threaded rod, and another sliding block is threadedly connected to its external thread. A rack is fixedly connected to the bottom of the sliding block. A limit rail is fixedly connected to the top of the inner wall of the transmission groove. The advantages of this utility model are that it ensures uniform drug particle size, enabling precise deposition in the respiratory tract and lungs, improving drug absorption efficiency, optimizing drug distribution, avoiding excessively high or low local drug concentrations, enhancing therapeutic effects, and reducing side effects. Compared to traditional devices, it significantly improves operational quality and efficiency.

The embodiment of the present application provides an IBC battery aluminum paste and an IBC battery, wherein the IBC battery aluminum paste provided by the embodiment of the present application comprises an organic additive, boron powder, aluminum powder, gallium powder, glass powder and an organic binder. By adding gallium powder in the aluminum paste, because the gallium element has etching effect and high density, it is faster than aluminum to drop to the silicon surface in the sintering process, so that the Ga-Si contact probability is increased, the contact resistance of the paste and the battery is reduced, and a high open circuit voltage can be maintained. At the same time, because part of the aluminum powder is replaced by gallium, the content of aluminum is reduced, which is beneficial to reducing the side effect of Al, so that the Al-Si reaction is weakened, the formed aluminum silicon corrosion pit is shallow, the recombination is reduced, so as to improve the open circuit voltage and the photoelectric conversion efficiency of the battery. Therefore, the problem that the existing IBC battery aluminum paste is easy to form metal recombination in the cooling process after being sintered into a positive electrode grid line, resulting in the decrease of the open circuit voltage and the photoelectric conversion efficiency of the battery piece is solved.

The application relates to the technical field of cell culture, in particular to application of Gremlin1 protein in promoting proliferation of adipose-derived cells. The application also provides a culture medium containing the Gremlin1 protein, which is used for culturing the adipose-derived cells, can significantly promote proliferation of the adipose-derived cells, and is significantly superior to a commercial special culture medium.

The invention discloses a traditional Chinese medicine monomer composition derived from chrysanthemum plants and used for treating diabetic retinopathy as well as a preparation method and application of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition prepared from the chrysanthemum plant as the raw material is high in safety, small in side effect and definite in component and is prepared according to a specific ratio, and pharmacodynamic experiments prove that compared with an ethanol extract, the traditional Chinese medicine monomer composition is more remarkable in curative effect on diabetic retinopathy, and the curative effect of the traditional Chinese medicine monomer composition on diabetic retinopathy is better than that of a traditional Chinese medicine composition on diabetic retinopathy. The composition can improve the pathological state of diabetic retinopathy from multiple targets and multiple ways, specifically can inhibit body mass increase caused by high glucose, reduce blood glucose level, improve retinal tissue structure damage, recover retinal tissue thickness, inhibit retinal cell apoptosis and inflammatory response, reduce the expression level of HIF-1alpha and VEGF protein in retinal tissue, and can be used for treating diabetic retinopathy. Scientific basis and technical support are provided for research and development of novel drugs for treating the diabetic retinopathy, and important clinical significance and market application prospects are achieved.

This invention discloses a method for preparing cell-derived exosome subsets, as well as products and applications, belonging to the field of biomedical technology. The preparation method includes: filtering cell culture medium to obtain a cell culture supernatant; concentrating the supernatant 5-30 times using a tangential flow system with a 300-500 kDa hollow fiber filter, followed by 10-20 times washing to obtain a concentrated solution; and performing Sephacryl S-400 HR gel filtration column chromatography, collecting the eluent from two 280 nm UV absorption peaks to obtain exosome subsets S1 and S2; the protein concentration of the concentrated solution is 20-50 mg / mL. This invention achieves, for the first time, precise separation of functional exosome subsets. Subset S1 exhibits strong immunomodulatory activity, and subset S2 demonstrates excellent cell regeneration promotion effects. Furthermore, the process is highly versatile and suitable for large-scale production. These subsets can be used to prepare immunomodulatory or cell regeneration-promoting drugs, providing precise technical solutions for the treatment of related diseases.

The invention discloses a method and a device for generating a commodity pool based on a new machine recommendation algorithm of big data. The method comprises the following steps: constructing a basic view through a Spark framework; performing popularity quantitative evaluation through a commodity popularity scoring model, and respectively screening out hot-sell commodities and new commodities; performing data matching through an SQL linked table query operation, and generating an initial candidate commodity set and a quantity target value of each type of commodities; calculating to obtain a comprehensive score through a multi-objective optimization model; partition-level commodity filtering and optimization are carried out through a MapReduce programming model, and an optimized commodity candidate pool is obtained; performing commodity compliance verification according to items of the white list, and based on a forbidden list in the dimension list black list, adding just-needed categories according to scene requirements through reverse connection operation to obtain a final commodity candidate pool; and merging the commodity data in the final commodity candidate pool into a hive table for persistent storage. The problems that in the prior art, consumption behavior recognition is lacked, and the requirement of a special scene cannot be met are solved.

The invention relates to the technical field of functional food, health care products and medicines, in particular to a composition for neuroprotection and cognitive function improvement and a preparation method and application thereof. The invention provides a composition for neuroprotection and cognitive function improvement. The composition is prepared from calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, by compounding the calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, the compound has a synergistic effect and can be applied to preparation of food, health care products or medicines for protecting nerves, delaying nerve aging, improving learning and memory ability, repairing nerve injury and preventing or assisting in treating neurodegenerative diseases.

The application relates to the field of medicine, and particularly discloses an osteogenic-targeting molecule modified 11beta-HSD1 inhibitor compound, and the structure of the compound is formula (I). The compound can target and inhibit 11beta-HSD1 in osteoblasts, thereby reducing side effects caused by inhibition of 11beta-HSD1, and can effectively treat metabolic diseases such as obesity and diabetes, and can also protect bone formation inhibition, low bone mass and bone structure damage accompanying metabolic diseases.

The present application relates to processing of wine rhizoma polygonati, in particular to a wine rhizoma polygonati processing equipment and a wine rhizoma polygonati processing method. The wine rhizoma polygonati processing equipment comprises a processing pot, the processing pot comprises an inner pot body, the inner pot body is provided with a material inlet and outlet for loading and taking out the raw material to be processed; the inner pot body is externally provided with a sandwich pot body, the space between the inner pot body and the sandwich pot body forms a steam sandwich layer, the steam sandwich layer is provided with a steam inlet; the material inlet and outlet of the inner pot body are provided with a sealable sealing cover; the sealing cover has an open state, and also has a closed state for processing the material in a closed state. The wine rhizoma polygonati processing method comprises the following steps: step one, keeping the raw material container loaded with the raw material to be processed in a completely closed state; step two, introducing water vapor into the steam sandwich layer outside the raw material container to separately stew the rhizoma polygonati soaked with yellow wine. The present application can solve the problem that the existing wine rhizoma polygonati processing equipment cannot easily ensure the content of wine rhizoma polygonati polysaccharide.

The invention provides a drug carrier based on N-acetylglucosamine, a drug preparation and a preparation method. The drug carrier based on N-acetylglucosamine comprises N-acetylglucosamine and a cross-linking agent, the cross-linking agent is a compound with an aldehyde group or a ketone group, and the aldehyde group or the ketone group reacts with the deacetylated N-acetylglucosamine to generate one or more of a hydrazide bond, a hydrazone bond or an imine bond. The drug carrier based on N-acetylglucosamine shows remarkable advantages in the aspects of particle size distribution, drug loading capacity, encapsulation efficiency and cumulative drug release rate.

A photothermal response type magnetic soft robot for gastrointestinal targeted therapy, and a preparation method and application thereof, are used to realize an oral drug delivery system integrating anti-acid protection, magnetic driving navigation and photothermal triggered drug release functions. The core is to provide a soft robot with a spherical core-shell structure, the core of which is composed of ferroferric oxide nanoparticles (Fe3O4) and a polydopamine (PDA) layer coated thereon, and the PDA layer is loaded with a therapeutic drug (such as antibiotic CIP); the shell is a calcium alginate hydrogel. The structure enables the robot to resist gastric acid and protect the drug activity. The robot can be precisely controlled in motion in a three-dimensional Helmholtz coil system through a multi-axis alternating magnetic field: the local temperature is raised by using the photothermal effect of Fe3O4@PDA, and after returning to body temperature, the operation is repeated several times, resulting in swelling and degradation of the calcium alginate shell, so as to realize the site-specific and rapid release of the drug.

This invention belongs to the field of biomedicine, specifically relating to siRNA that inhibits AR gene expression, comprising a sense strand and an antisense strand, wherein the sense strand and the antisense strand are at least partially anticomplementary to form a double-stranded region, and the sense strand or antisense strand consists of 19-25 nucleotides with blunt ends of complementary nucleotide sequences; or the antisense strand consists of 27 nucleotide sequences with overhangs. The siRNA of this invention can maintain long-term efficacy with a single dose, exhibiting good compliance in patients with chronic diseases such as androgenetic alopecia. Furthermore, it has lower off-target toxicity and fewer side effects compared to small molecule chemical drugs and hormone drugs.

The invention belongs to the technical field of natural pharmaceutical chemistry and medicine, and relates to a sesquiterpene compound and a separation method thereof, and application of the sesquiterpene compound in blood sugar reduction. According to the 14-acetylated 1-indanone type sesquiterpene glucoside compound disclosed by the invention, a new 14-acetylated 1-indanone type sesquiterpene glucoside compound, namely 14-acetyl-(2S, 3S)-Pterosine C-3-O-D glucoside, is separated and identified from pteris multifida poir for the first time. According to the compound, a new chemical entity is added for a natural product library, and valuable candidate molecules are provided for drug research and development. The sesquiterpene compound disclosed by the invention shows excellent alpha-glucosidase inhibitory activity; an in-vitro enzyme activity experiment shows that the sesquiterpene compound has a remarkable inhibition effect on alpha-glucosidase from yeast (the inhibition rate reaches 52.1% under the concentration of 10 mg / mL).

This invention relates to a traditional Chinese medicine composition, specifically a traditional Chinese medicine composition for treating diabetic nephropathy, belonging to the fields of medicine and health products. The traditional Chinese medicine composition of this invention is made from components comprising the following raw materials: yam, salvia miltiorrhiza, rosehip, turtle shell, cornus officinalis, dioscorea hypoglauca, cuscuta chinensis, oyster shell, and American ginseng. Through rational formulation, this traditional Chinese medicine composition utilizes the principle of clearing heat and removing dampness, with the synergistic effect of multiple drugs, to significantly reduce fasting blood glucose, improve glucose metabolism, lower low-density lipoprotein cholesterol and triglycerides, and raise high-density lipoprotein cholesterol to regulate lipid metabolism, reduce weight, and has no significant damage to liver and kidney function, with minimal side effects.

The application belongs to the technical field of biological medicine, and particularly relates to application of calcium chelator BAPTA and a pharmaceutical composition. The calcium chelator BAPTA delays aging of lung fibroblasts and lung tissues by eliminating calcium accumulation in lung fibroblasts, reducing accumulation of reactive oxygen species ROS (ROS) in lung fibroblasts, DNA damage, and release of inflammatory factors. The calcium chelator BAPTA ultimately realizes the function of treating pulmonary fibrosis by inhibiting weight loss, lung tissue inflammatory cell infiltration, lung collagen deposition, and expression of fibrosis markers. The application provides a new drug source for delaying aging of lung fibroblasts and lung tissues and studying occurrence and development of pulmonary fibrosis. The drug is safe and reliable, has strong pharmacological action, small side effects, and definite curative effect.

This invention belongs to the field of biodetection technology, specifically relating to a method for preparing and applying a fluorescent probe for screening monoamine oxidase B inhibitors. The method for preparing the fluorescent probe described in this invention is simple, convenient, and low in synthesis cost. The fluorescent probe prepared using this method exhibits good specificity and high sensitivity. The probe has a large fluorescence emission wavelength, which can effectively avoid fluorescence interference from chemical components in traditional Chinese medicine, thereby improving detection sensitivity. It shows promising application prospects in the screening of monoamine oxidase B inhibitors from traditional Chinese medicine.

The application discloses an engineered exosome targeting human urokinase-type plasminogen activator receptor uPAR and a preparation method and application thereof. Firstly, a high-affinity anti-human uPAR single-domain antibody VHH is prepared; then, a human umbilical cord mesenchymal stem cell engineering cell line expressing a VHH-PTGFRN fusion protein is constructed, and the engineered exosome is prepared and purified by combining three-dimensional hypoxic culture, chemical induction and size-exclusion chromatography technology. The engineered exosome comprises four comparative samples, wherein the core sample Exo^(VHH / miR) can simultaneously display the anti-uPAR VHH on the membrane surface to realize targeted delivery and enrich miR-193b-3p in the chamber to realize gene silencing, and the synergistic effect of the two can efficiently remove the uPAR high-expression senescent cells and inhibit the senescence-associated secretory phenotype SASP. The engineered exosome has the advantages of standardized preparation process, high yield and high purity, strong targeting, excellent curative effect and good safety, and can be used for preparing a treatment preparation for anti-aging and aging-related diseases, and has important clinical application value.

The application discloses strigasiaticaside A and an extraction method and application thereof, and finds, through chemical component research on the whole grass of striga asiatica, a new synbinaphthyl tetrahydrofuran lignan glycoside, that is, strigasiaticaside A, identifies the chemical structure of the new compound through nuclear magnetic resonance, mass spectrometry, ultraviolet, infrared and circular dichroism spectrum technology.The structure of the new compound is identified as (-) sesamin-5-O-beta-D-glucopyranoside.The anti-hepatitis activity of the new natural product is evaluated by using LPS stimulated HepG2 cells.The results show that when the concentration is 100 muM, the compound has a significant inhibitory effect on the production of inflammatory factors IL-10 and NF-kappa B protein, and has no cytotoxicity, indicating that the compound may have potential anti-hepatitis activity.

The present application relates to the application of cereal bran oligopeptide in the preparation of drugs and / or products for preventing and / or treating colorectal cancer metastasis, and belongs to the technical field of medical uses. The amino acid sequence of the cereal bran oligopeptide is shown in SEQ ID NO. 1 or SEQ ID NO. 2. The cereal bran oligopeptide can target and antagonize the activation of integrin alpha v beta 6 and alpha v beta 3 subtypes, effectively block the metastasis of colorectal cancer to distant organs such as liver and lung, significantly weaken the adhesion and invasion ability of colorectal adenocarcinoma cells, reduce the number of organ metastatic nodules, reduce the weight of organs, significantly improve the pathological damage of organ tissues, and has the advantages of high safety, small side effects, good biocompatibility, easy absorption and the like.

This invention provides a method for preparing a metformin compound hypoglycemic oral solution, relating to the pharmaceutical field, comprising: step S1, pretreatment of traditional Chinese medicine components; step S2, enzymatic hydrolysis of the first group of traditional Chinese medicine components; step S3, supercritical extraction; step S4, preparation of mixed traditional Chinese medicines; step S5, preparation of inclusion complex; step S6, compound formulation; and step S7, post-processing. This method synergistically combines extracts from seven traditional Chinese medicines—bitter melon, phellodendron bark, astragalus root, kudzu root, rehmannia root, ginseng, and privet fruit—with metformin hydrochloride to form a metformin compound hypoglycemic oral solution, balancing the synergy, safety, and stability of traditional Chinese and Western medicines, thereby improving hypoglycemic effects while reducing the incidence of gastrointestinal adverse reactions to metformin.

The present application provides a method of administration that maximizes the therapeutic effect of adrenomedullin, and a drug containing adrenomedullin provided by the method of administration. The above problem is solved by providing a drug for treating a disease, which contains adrenomedullin or a derivative thereof having adrenomedullin activity, etc. as an effective ingredient, characterized in that the disease is a disease for which a therapeutic effect is expected to be obtained by administration of adrenomedullin or a derivative thereof having adrenomedullin activity, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, and the effective ingredient is administered intermittently.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition suitable for type II diabetes and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 45 parts of radix astragali seu hedysari, 20 to 30 parts of herba dendrobii, 30 to 45 parts of rhizoma polygonati, 20 to 30 parts of radix ophiopogonis and 20 to 30 parts of corn stigma. According to the traditional Chinese medicine composition, through the synergistic effect of core components such as astragalus membranaceus for tonifying qi, lifting yang, promoting salivation and nourishing blood, dendrobium nobile for tonifying stomach and promoting salivation, polygonatum kingianum for tonifying qi, nourishing yin, moistening lung and tonifying kidney, radix ophiopogonis for nourishing yin and promoting salivation and the like, glucose metabolism balance is effectively adjusted, insulin resistance is improved, and therefore the effect of reducing blood glucose and / or lipid is achieved.

The invention belongs to the technical field of medicines, and particularly relates to a microneedle patch for disguising a macrophage cell membrane and a preparation method of the microneedle patch. Degradable high polymer material nano-particles camouflaged by the macrophage membrane are embedded in a microneedle array of the microneedle patch camouflaged by the macrophage membrane, and the degradable high polymer material nano-particles camouflaged by the macrophage membrane are wrapped with gambogic acid and oleic acid functionalized cerium dioxide nano-particles. Nanoparticles of the microneedle patch jointly load gambogic acid and oleic acid functionalized cerium dioxide, through microneedle transdermal drug delivery, active targeting of the drug to the liver is achieved by using natural inflammatory taxis of a macrophage membrane, the anti-inflammatory effect of gambogic acid and the anti-oxidation effect of cerium dioxide are synergistically exerted, polarization of macrophages is adjusted, and the anti-inflammatory effect of the drug on the liver is achieved. Therefore, the liver injury caused by the septic shock is treated.

The invention discloses a bispecific antibody-UC-MSCs preparation for targeting prostate diseases as well as preparation and application of the bispecific antibody-UC-MSCs preparation. The preparation comprises a bispecific antibody BsAb-1 and human umbilical cord mesenchymal stem cells (UC-MSCs), the BsAb-1 is formed by connecting an anti-CD105 single-domain antibody, an anti-PSCA single-domain antibody and a flexible peptide linker in series, wherein the amino acid sequence of the BsAb-1 is as shown in SEQ ID NO: 4. According to the preparation, the UC-MSCs are delivered to a prostate focus through the targeting bridge effect of BsAb-1, the focus enrichment amount within 72 hours is increased by 6.3 times compared with that of pure UC-MSCs, and meanwhile retention of non-target organs such as the liver and the spleen is reduced. The preparation can effectively relieve inflammatory response and fibrosis of chronic prostatitis, and the curative effect of the preparation is remarkably superior to that of pure UC-MSCs treatment. Precise targeted treatment of prostate diseases is achieved, the curative effect is remarkably better than that of a traditional stem cell therapy method, and high clinical application value is achieved.

The invention belongs to the technical field of microorganisms, and relates to a streptococcus salivarius subsp. Thermophilus Ss-PG-10 strain for relieving hyperuricemia and a preparation method of the streptococcus salivarius subsp. Thermophilus Ss-PG-10 strain. The strain provided by the invention is streptococcus salivarius subsp. Thermophilus Ss-PG-10, the classification name of the strain is Streptococcus salivarius subsp. Thermophilus, and the preservation number of the strain is CGMCC (China General Microbiological Culture Collection Center) No. 31867. The streptococcus salivarius subsp. Thermophilus Ss-PG-10 is separated from pickled Chinese cabbages, has a function of relieving hyperuricemia, has a certain antibacterial effect on pathogenic bacteria such as staphylococcus aureus, bacillus subtilis and escherichia coli, and has relatively strong acid resistance, cholate resistance and artificial simulated gastrointestinal fluid resistance.

The invention belongs to the technical field of natural medicine extracts, and relates to a polygonatum sibiricum flower bud extract as well as a preparation method, a microcapsule preparation and application thereof. The polygonatum sibiricum flower bud extract contains one or more of rutin, apigenin-6-arabinose-8-glucoside, and apigenin-6, 8-diglucoside, and is characterized in that the polygonatum sibiricum flower bud extract contains one or more of rutin, apigenin-6-arabinose-8-glucoside and apigenin-6, 8-diglucoside. By utilizing the preparation method of the polygonatum sibiricum flower bud extract and the preparation method of the microcapsule preparation, the polygonatum sibiricum flower bud extract and the microcapsule preparation of the polygonatum sibiricum flower bud extract can be better prepared respectively; the prepared polygonatum sibiricum flower bud extract and the microcapsule preparation of the polygonatum sibiricum flower bud extract can better inhibit the activity of alpha-glucosidase in vivo and in vitro, and can be used for preventing or treating diabetes mellitus with better curative effect and smaller side effect.

This invention provides a drug-loaded halloysite material, its preparation method, and its application. The drug-loaded halloysite material is prepared from halloysite, a drug, and an encapsulation material. Halloysite has good loading and sustained-release effects on drugs such as ciprofloxacin, diclofenac sodium, and nicotinic acid. Encapsulation with the encapsulation material further delays the release of the drug, resulting in slow release in the intestine and stomach, achieving targeted and controlled release. In addition, its preparation method is simple and can achieve rapid encapsulation, further avoiding drug loss during the encapsulation process. It can be used in the biomedical field, especially in the application of sustained-release drugs and intestinal targeted drug delivery, showing good application prospects.