186results about How to "Little side effects" patented technology

The invention provides a method for detecting the moisture content of buccal cigarette contents, and belongs to the technical field of smokeless tobacco product analysis and detection. The method comprises the following steps: step 1, taking a proper amount of a buccal cigarette content sample; 2, preparing a detection solution; step 3, mixing and extracting the buccal cigarette content sample and the detection liquid to obtain extract liquor, calibrating a Karl-Fischer moisture titrator, adding the extract liquor into a titration cup containing methanol, and carrying out titration detection by using a Karl-Fischer reagent; or adding the detection liquid into a titration cup containing methanol, calibrating a Karl-Fischer moisture titrator, adding the buccal cigarette content sample into the titration cup, stirring and dissolving, and carrying out titration detection by using a Karl-Fischer reagent. The detection method provided by the invention is suitable for various buccal cigarette products, broadens a detection way for quality detection of the buccal cigarette and improvement of smoking quality, and has a very good practical application value.

The invention discloses application of vimogib in preparation of a product for delaying and / or reversing T cell senescence, and belongs to the field of biological medicine. Experiments prove that the vimogii can enhance the lysosome function of T cells by enhancing the expression of TFE3 protein, so that the expression of anti-tumor and anti-virus related cytokines is enhanced, the lysosome function of senescent T cells of old people is improved, and the anti-tumor and anti-virus infection capability of the old people is enhanced. It is found for the first time that vimogii can improve the lysosome function of T cells by enhancing TFE3 protein expression, and the blank in the field is filled. According to the application, a new treatment thought is provided for improving immune aging related diseases of old people, the T cell lysosome function is enhanced by enhancing TFE3 protein expression through the medicine, then T cell aging is delayed and / or reversed, and an innovative application direction is provided for intervention of an aging immune system.

The invention relates to application of chenodeoxycholic acid or pharmaceutically acceptable salt thereof in preparation of a medicine for treating acne. The chenodeoxycholic acid disclosed by the invention can be a natural organic compound or a synthetic organic compound, has relatively strong propionibacterium acnes inhibitory activity and a pharmacodynamic effect of resisting lipid secretion, and is used as an active component to be prepared into a pharmaceutical composition for treating acnes together with a pharmaceutically acceptable carrier.

The invention provides a composition for treating nerve headache and a preparation method thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: carrying out steam explosion treatment on traditional Chinese medicine powder, adding the traditional Chinese medicine powder into saline water, decocting, filtering, standing filtrate to separate out a hydrochloric acid extract, adding filter residues into ethanol, adsorbing by a magnetic adsorbent, separating by a magnet, eluting, desorbing, recovering an eluent to obtain an alcohol extract, mixing and grinding the alcohol extract, the hydrochloric acid extract and flunarizine hydrochloride / nimodipine eutectic, and filling capsules with the alcohol extract and the flunarizine hydrochloride / nimodipine eutectic. The composition for treating the nerve headache is prepared. The traditional Chinese medicine composition treats neuropathic migraine through a method of combining traditional Chinese medicine and western medicine, treats both symptoms and root causes, and is good in effect and quick and lasting in effect.

This invention belongs to the field of traditional Chinese medicine technology, and provides a traditional Chinese medicine composition with the effects of clearing the throat and relieving cough, and its preparation method. The traditional Chinese medicine composition contains the following components: Scrophularia ningpoensis, Ophiopogon japonicus, Platycodon grandiflorus, Terminalia chebula, Mentha haplocalyx, Paeonia lactiflora, Glycyrrhiza uralensis, Borneol, and rice wine. This traditional Chinese medicine composition nourishes Yin and moistens dryness, cools the blood and reduces swelling, clears the throat and relieves cough, and can effectively improve symptoms such as sore throat, foreign body sensation in the throat, hoarseness, dry and itchy throat, and irritating dry cough caused by endotracheal intubation or gastric tube placement. This traditional Chinese medicine composition has definite efficacy, high safety, and few side effects, and has excellent clinical application and industrialization prospects.

The present application belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition and application thereof in preparation of an oral care product. The traditional Chinese medicine composition is prepared from 12-18 parts of Qingdai, 7-12 parts of raw gypsum, 7-12 parts of Huangqi, 9-15 parts of Gushugu, 3-7 parts of Honghuajiao, 3-7 parts of Baizhi, 6-10 parts of Fangfeng, 1-5 parts of Bajie, 6-10 parts of Huanylencao, 1-5 parts of Wuji, and 4-8 parts of Baiji as raw medicinal materials. The components of the composition are reasonably matched, and can realize multiple effects of analgesia, antibiosis, anti-inflammation, repair, and tooth fixation and health. The present application is suitable for all kinds of toothache patients, has a wide application range, a safe use mode, and a wide market application prospect.

This utility model relates to the field of atomization spray technology, specifically an atomization spray precision control device. The device includes an atomizer with a side-hollow structure. A baffle plate is located inside the atomizer, and a transmission groove is formed within the atomizer. A connecting rod is fixedly connected to the top of the baffle plate. The top of the connecting rod extends into the transmission groove and is fixedly connected to a gear. A threaded rod is rotatably connected inside the transmission groove. A sliding block is threadedly connected to the external thread of the threaded rod, and another sliding block is threadedly connected to its external thread. A rack is fixedly connected to the bottom of the sliding block. A limit rail is fixedly connected to the top of the inner wall of the transmission groove. The advantages of this utility model are that it ensures uniform drug particle size, enabling precise deposition in the respiratory tract and lungs, improving drug absorption efficiency, optimizing drug distribution, avoiding excessively high or low local drug concentrations, enhancing therapeutic effects, and reducing side effects. Compared to traditional devices, it significantly improves operational quality and efficiency.

The present invention relates to an antibacterial protein SBL200 having a bacteriolytic activity specific to Streptococci, and a method for preparing the antibacterial protein SBL200 having a bacteriolytic activity specific to Streptococci. More particularly, the present invention relates to: an antibacterial protein SBL200 specific for streptococcus, which is characterized by having an ability to specifically lyse streptococcus and having an amino acid sequence represented by SEQ ID NO: 1; and a composition for treating infection induced by streptococcus, which contains the antibacterial protein SBL200 specific for streptococcus as an active ingredient .

The invention discloses application of a pharmaceutical composition in preparation of a medicine for treating nephropathy, the nephropathy is at least one of membranous glomerulonephritis, postoperative acute kidney injury caused by non-contrast agents, immunoglobulin A nephropathy, purpura nephritis and idiopathic focal segmental glomerulosclerosis, and the pharmaceutical composition belongs to the technical field of pharmacy. The pharmaceutical composition is prepared from the following flavonoid components in a mass ratio: the mass ratio of the gossypothelin-8-O-beta-D-glucuronide to the hyperoside to the isoquercitrin to the myricetin to the quercetin-3 '-O-glucoside is 10 to (3.0 to 20) to (2.0 to 18) to (0.2 to 6.0) to (1 to 20). The pharmaceutical composition has obvious effects of preventing and / or treating membranous glomerulonephritis, postoperative acute kidney injury caused by non-contrast agents, immunoglobulin A nephropathy, purpura nephritis and idiopathic focal segmental glomerulosclerosis, and has relatively good safety.

The embodiment of the present application provides an IBC battery aluminum paste and an IBC battery, wherein the IBC battery aluminum paste provided by the embodiment of the present application comprises an organic additive, boron powder, aluminum powder, gallium powder, glass powder and an organic binder. By adding gallium powder in the aluminum paste, because the gallium element has etching effect and high density, it is faster than aluminum to drop to the silicon surface in the sintering process, so that the Ga-Si contact probability is increased, the contact resistance of the paste and the battery is reduced, and a high open circuit voltage can be maintained. At the same time, because part of the aluminum powder is replaced by gallium, the content of aluminum is reduced, which is beneficial to reducing the side effect of Al, so that the Al-Si reaction is weakened, the formed aluminum silicon corrosion pit is shallow, the recombination is reduced, so as to improve the open circuit voltage and the photoelectric conversion efficiency of the battery. Therefore, the problem that the existing IBC battery aluminum paste is easy to form metal recombination in the cooling process after being sintered into a positive electrode grid line, resulting in the decrease of the open circuit voltage and the photoelectric conversion efficiency of the battery piece is solved.

The application relates to the technical field of cell culture, in particular to application of Gremlin1 protein in promoting proliferation of adipose-derived cells. The application also provides a culture medium containing the Gremlin1 protein, which is used for culturing the adipose-derived cells, can significantly promote proliferation of the adipose-derived cells, and is significantly superior to a commercial special culture medium.

The invention discloses a traditional Chinese medicine monomer composition derived from chrysanthemum plants and used for treating diabetic retinopathy as well as a preparation method and application of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition prepared from the chrysanthemum plant as the raw material is high in safety, small in side effect and definite in component and is prepared according to a specific ratio, and pharmacodynamic experiments prove that compared with an ethanol extract, the traditional Chinese medicine monomer composition is more remarkable in curative effect on diabetic retinopathy, and the curative effect of the traditional Chinese medicine monomer composition on diabetic retinopathy is better than that of a traditional Chinese medicine composition on diabetic retinopathy. The composition can improve the pathological state of diabetic retinopathy from multiple targets and multiple ways, specifically can inhibit body mass increase caused by high glucose, reduce blood glucose level, improve retinal tissue structure damage, recover retinal tissue thickness, inhibit retinal cell apoptosis and inflammatory response, reduce the expression level of HIF-1alpha and VEGF protein in retinal tissue, and can be used for treating diabetic retinopathy. Scientific basis and technical support are provided for research and development of novel drugs for treating the diabetic retinopathy, and important clinical significance and market application prospects are achieved.

The present application relates to the technical field of traditional Chinese medicine, more specifically, the present application relates to a kind of oral and external application composition for treating penile cavernosal induration, it is characterized in that;Including oral traditional Chinese medicine and external traditional Chinese medicine;Oral traditional Chinese medicine includes: xuan Shen, chuanbei, jieshan, curcuma, bupleurum, white peony root, angelica, dried tangerine or orange peel, calcined oyster, cat's claw, earthworm, green skin, clear pinellia ternata, spirea, kelp and seaweed;External traditional Chinese medicine includes: smilax glabra, gallnut, salvia miltiorrhiza, curcuma, safflower, seaweed, geocrypta, snowbell and white plantain powder.The main purpose of the present application is to provide an effective, safe and comprehensive treatment method by combining oral and external traditional Chinese medicine, to improve the treatment effect of penile cavernosal induration, reduce side effects, improve the quality of life of patients, and reduce the recurrence rate of disease.

The present invention provides a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof and an anti-cancer agent for the treatment of cancer wherein the compound of formula (I) is a bifunctional compound having G12D mutant KRAS inhibitory activity, and wherein the compound of formula (I) and the anti-cancer agent are as described in the specification.

The invention provides a traditional Chinese medicine composition for treating children atopic dermatitis and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials: 4-8 parts of rhizoma atractylodis, 6-10 parts of honeysuckle, 4-8 parts of cortex phellodendri, 4-8 parts of semen coicis, 4-8 parts of radix achyranthis bidentatae, 2-8 parts of radix sophorae flavescentis, 4-8 parts of cortex dictamni, 4-8 parts of fructus kochiae, 2-8 parts of cicada slough and The preparation method comprises the following steps: soaking the traditional Chinese medicinal materials in water, heating, refluxing, extracting, filtering and taking filtrate; concentrating the filtrate into clear paste, cooling, adding ethanol, standing, taking supernate, recovering ethanol, performing secondary concentration to obtain traditional Chinese medicine ointment, and granulating the traditional Chinese medicine ointment. The traditional Chinese medicine and modern pharmacological actions are combined to achieve the effects of clearing heat, eliminating dampness, tonifying spleen, excreting dampness, dispelling wind and arresting itching; in practical application, the traditional Chinese medicine composition has obvious improvement and cure conditions on children atopic dermatitis symptoms, and has the advantages of quick response, short curative effect, low side effect and no relapse after healing.

This invention discloses a method for preparing cell-derived exosome subsets, as well as products and applications, belonging to the field of biomedical technology. The preparation method includes: filtering cell culture medium to obtain a cell culture supernatant; concentrating the supernatant 5-30 times using a tangential flow system with a 300-500 kDa hollow fiber filter, followed by 10-20 times washing to obtain a concentrated solution; and performing Sephacryl S-400 HR gel filtration column chromatography, collecting the eluent from two 280 nm UV absorption peaks to obtain exosome subsets S1 and S2; the protein concentration of the concentrated solution is 20-50 mg / mL. This invention achieves, for the first time, precise separation of functional exosome subsets. Subset S1 exhibits strong immunomodulatory activity, and subset S2 demonstrates excellent cell regeneration promotion effects. Furthermore, the process is highly versatile and suitable for large-scale production. These subsets can be used to prepare immunomodulatory or cell regeneration-promoting drugs, providing precise technical solutions for the treatment of related diseases.

The invention discloses a method and a device for generating a commodity pool based on a new machine recommendation algorithm of big data. The method comprises the following steps: constructing a basic view through a Spark framework; performing popularity quantitative evaluation through a commodity popularity scoring model, and respectively screening out hot-sell commodities and new commodities; performing data matching through an SQL linked table query operation, and generating an initial candidate commodity set and a quantity target value of each type of commodities; calculating to obtain a comprehensive score through a multi-objective optimization model; partition-level commodity filtering and optimization are carried out through a MapReduce programming model, and an optimized commodity candidate pool is obtained; performing commodity compliance verification according to items of the white list, and based on a forbidden list in the dimension list black list, adding just-needed categories according to scene requirements through reverse connection operation to obtain a final commodity candidate pool; and merging the commodity data in the final commodity candidate pool into a hive table for persistent storage. The problems that in the prior art, consumption behavior recognition is lacked, and the requirement of a special scene cannot be met are solved.

The invention relates to the technical field of functional food, health care products and medicines, in particular to a composition for neuroprotection and cognitive function improvement and a preparation method and application thereof. The invention provides a composition for neuroprotection and cognitive function improvement. The composition is prepared from calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, by compounding the calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, the compound has a synergistic effect and can be applied to preparation of food, health care products or medicines for protecting nerves, delaying nerve aging, improving learning and memory ability, repairing nerve injury and preventing or assisting in treating neurodegenerative diseases.

The application relates to the field of medicine, and particularly discloses an osteogenic-targeting molecule modified 11beta-HSD1 inhibitor compound, and the structure of the compound is formula (I). The compound can target and inhibit 11beta-HSD1 in osteoblasts, thereby reducing side effects caused by inhibition of 11beta-HSD1, and can effectively treat metabolic diseases such as obesity and diabetes, and can also protect bone formation inhibition, low bone mass and bone structure damage accompanying metabolic diseases.

The present application relates to processing of wine rhizoma polygonati, in particular to a wine rhizoma polygonati processing equipment and a wine rhizoma polygonati processing method. The wine rhizoma polygonati processing equipment comprises a processing pot, the processing pot comprises an inner pot body, the inner pot body is provided with a material inlet and outlet for loading and taking out the raw material to be processed; the inner pot body is externally provided with a sandwich pot body, the space between the inner pot body and the sandwich pot body forms a steam sandwich layer, the steam sandwich layer is provided with a steam inlet; the material inlet and outlet of the inner pot body are provided with a sealable sealing cover; the sealing cover has an open state, and also has a closed state for processing the material in a closed state. The wine rhizoma polygonati processing method comprises the following steps: step one, keeping the raw material container loaded with the raw material to be processed in a completely closed state; step two, introducing water vapor into the steam sandwich layer outside the raw material container to separately stew the rhizoma polygonati soaked with yellow wine. The present application can solve the problem that the existing wine rhizoma polygonati processing equipment cannot easily ensure the content of wine rhizoma polygonati polysaccharide.

The invention provides a drug carrier based on N-acetylglucosamine, a drug preparation and a preparation method. The drug carrier based on N-acetylglucosamine comprises N-acetylglucosamine and a cross-linking agent, the cross-linking agent is a compound with an aldehyde group or a ketone group, and the aldehyde group or the ketone group reacts with the deacetylated N-acetylglucosamine to generate one or more of a hydrazide bond, a hydrazone bond or an imine bond. The drug carrier based on N-acetylglucosamine shows remarkable advantages in the aspects of particle size distribution, drug loading capacity, encapsulation efficiency and cumulative drug release rate.

A photothermal response type magnetic soft robot for gastrointestinal targeted therapy, and a preparation method and application thereof, are used to realize an oral drug delivery system integrating anti-acid protection, magnetic driving navigation and photothermal triggered drug release functions. The core is to provide a soft robot with a spherical core-shell structure, the core of which is composed of ferroferric oxide nanoparticles (Fe3O4) and a polydopamine (PDA) layer coated thereon, and the PDA layer is loaded with a therapeutic drug (such as antibiotic CIP); the shell is a calcium alginate hydrogel. The structure enables the robot to resist gastric acid and protect the drug activity. The robot can be precisely controlled in motion in a three-dimensional Helmholtz coil system through a multi-axis alternating magnetic field: the local temperature is raised by using the photothermal effect of Fe3O4@PDA, and after returning to body temperature, the operation is repeated several times, resulting in swelling and degradation of the calcium alginate shell, so as to realize the site-specific and rapid release of the drug.