2 results about "Fatigue symptoms" patented technology

This invention provides a hemp seed protein peptide that enhances immunity and serum protein levels, along with its preparation method and applications, belonging to the field of hemp seed protein peptide technology. The preparation method includes: pulverizing defatted hemp seed meal and sequentially subjecting it to hydrolysis by a complex polysaccharide enzyme, a protease, and an amidase to obtain an enzymatic hydrolysate. This hydrolysate is then processed to obtain the hemp seed protein peptide. The complex polysaccharide enzyme is a combination of cellulase, pectinase, and xylanase; the protease is pepsin; and the amidase is PNGase F. The hemp seed protein peptide of this invention has the following significant effects: 1. Significantly improves serum albumin, immunoglobulin, prealbumin, and total protein levels and immunity in middle-aged and elderly individuals, those with weak constitutions / poor nutritional status, and those recovering from illness / surgery; 2. Rapidly improves fatigue symptoms in these individuals, such as emaciation, weakness, lethargy, and poor sleep, boosting energy and relieving limb heaviness and soreness.

This invention belongs to the field of pharmaceutical applications, specifically the application of esketamine hydrochloride in the preparation of drugs for the prevention and treatment of postoperative fatigue syndrome. Through experiments, this invention demonstrates that esketamine hydrochloride improves fatigue symptoms in a rat model of postoperative fatigue syndrome by enhancing exercise endurance and coordination, improving exercise speed, promoting the recovery of autonomous exploratory behavior, and reducing apoptosis in CA1 cells of the hippocampus. The effects are significant within a short period, with no obvious adverse reactions, demonstrating safety and feasibility. This invention discovers a novel effect of esketamine hydrochloride in preventing and treating postoperative fatigue syndrome, expanding its clinical application. Esketamine hydrochloride is convenient to administer and has good compliance, making it highly clinically applicable in the prevention and treatment of postoperative fatigue syndrome.