The invention provides real simple tonic wine which comprises distilled spirit utilizing grains as raw materials and following medicaments in parts by weight: 5-17 parts of Chinese yam, 5-17 parts of cynomorium, 5-17 parts of broomrape, 5-17 parts of grifola umbellata, 5-17 parts of morinda root, 5-17 parts of tuckahoe, 5-17 parts of Chinese wolfberry, 3-16 parts of brazilwood, 3-16 parts of astragalus mongholicus, 3-16 parts of flastem milkvetch seed, 3-16 parts of radix rehmanniae, 3-16 parts of rehmannia glutinosa, 3-16 parts of pipefish, 3-16 parts of american ginseng, 3-16 parts of jobstears seed, 3-16 parts of dodder, 3-16 parts of prepared aconite, 1-15 parts of ophiopogon root, 1-15 parts of radix asparagi, 1-15 parts of solomonseal, 1-15 parts of dendrobe, 1-15 parts of bitter cardamon, 1-15 parts of epimedium, 1-15 parts of eclipta, 1-15 parts of dry longan,1-15 parts of pulp of dogwood fruit, 1-15 parts of magnolia vine fruit, 1-15 parts of cinnamomum cassia, 1-15 parts of prepared fleece-flower root, 1-15 parts of ligusticum, 1-15 parts of red sage root, 1-15 parts of spatholobus stem, 1-15 parts of teasel root, 1-15 parts of cumin, 1-15 parts of saffron crocus, 1-15 parts of Chinese chive seed, 1-15 parts of ganoderma lucidum, 1-15 parts of mantis egg-case, 1-15 parts of psoralea corylifolia, 1-15 parts of atractylis ovata and 1-15 parts of licorice. The real simple tonic wine is prepared through the following steps of: soaking the medicaments with the distilled spirit prepared from grains 8-16 times as weight as the medicament and having the alcohol content of no less than 50 degrees; and removing medicine dregs to obtain the real simple tonic wine. The real simple tonic wine is health-care wine, has a function of enhancing kidney and spleen, and can be used for improving the problems of physical fatigue, lassitude, poor sleeping quality and the like caused by working tiredness or excess social activities of the elderly.