The invention discloses a sleep control system and method of a vehicle controller. The sleep control system of the vehicle controller comprises a power interface, an MCU (Microprogrammed Control Unit), a working module, a wake-up source and an SBC (System Basis Chip), wherein the SBC comprises an external wake-up source input module and a voltage stabilizing module, the external wake-up source input module is connected with the wake-up source, the input end of the voltage stabilizing module is connected with the power interface, and the output end of the voltage stabilizing module is connectedwith the MCU; and the wake-up source is also connected to the MCU. According to the invention, an SBC is introduced into the sleep control system, and because the SBC integrates a voltage stabilizerand an external wake-up source input module, the circuit design is greatly simplified, and the cost is reduced; in addition, by using a wake-up function of the external wake-up source input module onthe SBC, when the system sleeps, the power supply of all modules except the SBC is turned off, and only part of the functions of the SBC are retained, thus greatly reducing the static power consumption of the system without affecting the response time of the system to external signals.