The invention relates to the technical field of medicines, in particular to novel application of
kidney-tonifying and bone-strengthening capsules. The
intervention effect of the
kidney-tonifying and bone-strengthening capsules on castrated rats is evaluated through systematic pharmacodynamic experiments. Experimental results show that the
kidney-tonifying and bone-strengthening
capsule can significantly improve the level of estradiol (E2) in serum, improve metabolic disorders and inhibit abnormal weight increase caused by
castration; therefore, the kidney-tonifying and bone-strengthening
capsule can be applied to preparation of a
medicine for regulating the in-vivo
estrogen level of a menopausal female or a
castration female; or the composition is applied to preparation of medicines for preventing abnormal
weight growth after female
menopause or
castration. In addition, Micro-CT and histopathologic analysis prove that the kidney-tonifying and bone-strengthening
capsule can effectively recover the
bone density and improve the bone
microstructure; the kidney-tonifying and bone-strengthening capsule can be applied to preparation of medicines for preventing or treating menopausal or castration female
osteoporosis, provides a new
Chinese patent medicine option for
medicine treatment of
osteoporosis, and enriches clinical medication choices.