34 results about "Menopausal Symptom" patented technology

The invention discloses an intelligent monitoring system for climacteric symptoms, and relates to the technical field of intelligent medical monitoring management, and the system comprises the following components: a monitoring device which is used for collecting physiological data of a user in real time, including body temperature, heart rate, blood pressure, sweat secretion, emotional fluctuation and sleep quality, the monitoring device is composed of a plurality of sensors and is worn on the body of a user. According to the intelligent monitoring system for the climacteric symptoms, the logic judgment steps of similarity comparison and repeated correction are added before health management suggestions are generated, the consistency and accuracy of a prediction report and a monitoring report on the numerical level can be effectively improved, and therefore interference of accidental noise or abnormal events on a final decision is reduced; and the scientificity, the accuracy and the reliability of the intelligent climacteric symptom monitoring system are improved.

The invention discloses a climacteric syndrome health management platform based on big data, and relates to the field of female health management. Comprising a marker monitoring module, a data acquisition and processing module, a health portrait modeling module, a personal health assessment module, a climacteric prediction module, an intervention scheme recommendation module, a medical data protection module, a digital health interaction module, a combined intervention module, a health community mutual assistance module and an exercise guidance module. According to the method, more accurate climacteric health state prediction and trend visualization are realized, the evaluation precision of climacteric symptom severity is improved, manual intervention strategy adjustment is not needed, the intervention effect is improved, the user compliance is enhanced, data security and privacy protection are ensured, and the user experience is improved by combining the physique and physiological indexes of the user. A personalized traditional Chinese and western medicine combined intervention scheme is matched, and the scientificity and effectiveness of intervention are improved.

The invention relates to the technical field of microorganisms and fermentation engineering, in particular to a lactobacillus plantarum strain and a method for preparing a traditional Chinese medicine fermented beverage. The strain is preserved in Guangdong Microbial Culture Collection Center on December 13, 2024, and the preservation number is CGDMCC (China General Microbiological Culture Collection Center) NO: 65639. The invention provides a method for preparing a blood replenishing beverage by fermenting the strain, and the method comprises the following steps: mixing a traditional Chinese medicine extracting solution, a ginseng concentrated solution and pomegranate concentrated juice to obtain a mixed liquid medicine, and then inoculating lactobacillus plantarum YXLP-116 for fermentation. The fermented beverage has the effects of regulating internal secretion, improving reproductive health and relieving climacteric symptoms. Experimental results show that the beverage can significantly reduce the FSH and LH levels and improve the E2 level, and has high safety and cell protection effect. Animal experiments further prove the potential of the protein in the aspect of regulating endocrine.

Aspects of disclosure relate to a composition and methodology for treating menopause symptoms utilizing a cannabinoid-based nanoplatform composition. The composition includes phytocannabinoids like CBD, CBG, and CBN, alongside isoflavones and polyphenols, all integrated into nanoplatform designed for enhanced bioavailability and controlled release. The formulation is designed to alleviate key menopause-related issues, including vasomotor symptoms (VMS), genitourinary syndrome of menopause (GSM), bone loss, mood disturbances, and sleep disorders, while addressing cardiovascular disease (CVD) risks. The composition combines cannabinoids, such as CBD, with isoflavones and polyphenols, and is incorporated into nanoplatforms for enhanced delivery and efficacy. Additionally, the disclosure includes a kit comprising oral capsules, intravaginal ovules, and instructions for use. The capsules contain a blend of cannabinoids, flavonoids, and polyphenols, while the ovules are composed of CBD and cocoa butter. The kit provides a comprehensive solution for managing menopause symptoms and mitigating cardiovascular risks.

The invention belongs to the field of traditional Chinese medicines, and provides application of a valerian extract in preparation of a medicine for preventing and treating climacteric syndrome. Pharmacological experiments show that the valerian extract has a regulation effect on a hypothalamic-pituitary-neuroendocrine system, and has important significance in regulating postmenopausal endocrine conditions of middle-aged and old women and improving anxiety, insomnia, dysphoria and other climacteric symptoms related to FSH (follicle stimulating hormone) and LH (luteinizing hormone). In addition, the valerian extract has a good regulation effect on secretion of related sex hormones and hypothalamus neurotransmitters of climacteric rats, and has a certain correction effect on the central monoamine neurotransmitter disorder state of the climacteric rats. The traditional Chinese medicine composition can improve clinical symptoms of climacteric syndrome.

The invention discloses an artificial intelligence female climacteric medical data auxiliary processing method and system, and relates to the technical field of medical data auxiliary processing. The monitoring module is set, the monitoring module is a wearable intelligent device, physical sign information data and environment information data of a target patient are obtained based on the monitoring module, and feature information items and environment information items are obtained; the acquisition module is used for acquiring questionnaire score information of a target patient to obtain questionnaire information items; by setting the monitoring module of the wearable intelligent device, the typical hot tide phenomenon of female climacteric is accurately captured, body surface temperature and current change data are obtained through a micro heat-sensitive sensor and a micro current sensor, accurate feature information items are obtained through strict threshold judgment, meanwhile, environment information data such as noise and illumination can be obtained, and the intelligent female climacteric monitoring system is suitable for being used for monitoring female climacteric climacteric conditions. Interference of environmental factors on female endocrine and climacteric symptoms is comprehensively considered.

This invention relates to the use of compounds represented by Chemical Formula 1 and / or compounds represented by Chemical Formula 2, or salts of compounds represented by Chemical Formula 1 and / or salts of compounds represented by Chemical Formula 2, in the manufacture of compositions for the treatment, prevention, or improvement of menopausal symptoms in women, wherein the compositions comprise compounds represented by Chemical Formula 1 and / or compounds represented by Chemical Formula 2, or salts of compounds represented by Chemical Formula 1 and / or salts of compounds represented by Chemical Formula 2, Chemical Formula 1 Chemical Formula 2:

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine formula for treating climacteric syndrome and a preparation method thereof.The traditional Chinese medicine formula is formed by compatibility of tuber fleeceflower stem, polygala tenuifolia, rhizoma acori graminei and other raw materials according to a specific proportion, the preferable proportion is clear, the formula contains specific active ingredient groups, and the content of the active ingredient groups reaches the standard through HPLC determination. The composition is accurate in compatibility, can comprehensively condition and improve various climacteric symptoms such as hectic fever, night sweat, insomnia and the like, and is definite in active ingredients, reliable in curative effect, high in universality and high in safety. The preparation method comprises specific decoction steps, such as first decoction of the raw dens draconis, staged decoction and adoption of a gradient heating process, the drug effect is improved, meanwhile, the quality is guaranteed through strict quality control, the process is flexible, various dosage forms can be prepared, the traditional Chinese medicine formula is combined with the preparation method, and the traditional Chinese medicine composition has an efficient and safe treatment effect on the climacteric syndrome and is worthy of popularization and application. The clinical application value is obvious.

Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including in overweight or obese subjects. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation or symptoms of menopause, including in overweight or obese subjects.

The method treats or prevents menopausal symptoms in cognitive function, and includes administering to a human female experiencing or at risk of menopausal symptoms in cognitive function an effective amount of a combination of an isoflavone source and at least one of a natural extract for supporting cognitive performance and a natural extract for promoting calmness and reducing stress. The combination may be administered in a composition further comprising one or more of vitamin B12, vitamin B6, a vitamin B complex, iron, magnesium, and / or a cooling / cooling agent. A single dose or multiple doses of the composition may be administered per day, with the multiple doses including a first dose and a second dose. The first dose may be administered to the human female in the morning, and the second dose may be administered to the human female in the evening.

The invention relates to application of ergothioneine in preparation of a preparation for improving an ovarian reserve function. The invention creatively discovers that the ergothioneine has the function of improving the ovarian reserve function, and the obvious clinical value of the ergothioneine for people with the serum AMH level of 1.0-3.0 ng / mL in the key'window phase 'is defined for the first time. The ergothioneine not only can improve the serum AMH level and the sinus follicle count (AFC), but also can significantly reduce the abnormally increased FSH and LH levels. Meanwhile, aiming at bone loss caused by ovarian reserve function decline, the ergothioneine shows an excellent bone quality protection effect, the bone density can be improved, and the thickness and number of bone trabecula can be increased. In addition, the ergothioneine can improve climacteric symptoms, effectively maintain the nutritional state of target organs such as uterus, delay atrophy and regulate menstrual cycle disorder.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, the described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. More preferably, the modified oil phase droplets of the MOIW microemulsion directly solubilize nonderivatized hormones. The oil phase droplets of the MOIW microemulsion include DHEA, pregnenolone, and a polyphenol, where a ratio of DHEA to polyphenol is from 1:1 to 12:1 by weight. Methods of supporting and / or increasing bloodstream hormone levels in perimenopausal and postmenopausal females and improving menopausal symptoms also are disclosed.

This document discloses compositions comprising one or more polyglutamic acid compounds. These compositions are used to treat, improve, prevent, or alleviate symptoms of vaginal dryness and menopausal symptoms. This document also describes compositions for treating, improving, preventing, or alleviating other dry skin symptoms on the body, extremities, hands, feet, neck, or face in subjects of all ages and sexes. This document also describes topical and suppository formulations of the compositions.

It is an object to provide a novel technology that can improve a female menopausal symptom. Provided is an agent for improving a female menopausal symptom, containing a Lactobacillus strain that is Lactobacillus gasseri CP2305 strain (accession number: FERM BP-11331), a processed product of the Lactobacillus strain, or an extract thereof.

The invention discloses a composition of plant extracts capable of taking effect quickly and probiotics capable of taking effect for a long time and application of the composition of the plant extracts capable of taking effect quickly and the probiotics capable of taking effect for a long time. The composition comprises a first composition which takes effect quickly, further comprises a plant extract and a second composition which takes effect for a long time, and further comprises one or more of probiotics, prebiotics and metabiotics. The first composition and the second composition are used for improving digestive system functions, enhancing intestinal barriers, enhancing immunity, improving mood, relieving pressure and anxiety, improving female health, relieving climacteric symptoms, improving uncomfortable symptoms in the menstrual period, controlling and managing body weight and improving oral health through a synergistic effect.

The present invention relates to therapeutic and non-therapeutic use of combinations of bacterial strains. In particular the use is for preventing or alleviating symptoms of menopause or climacteric symptom in a female mammal. Also disclosed herein are specific combinations of bacterial strains and their use in, as well as methods for reducing the need for estrogen replacement therapy, or for use in combination with estrogen replacement therapy, or other menopausal hormone replacement therapies.

The present invention relates to benzothiophene derivatives modulators, processes for their preparation and use. In particular, the present invention relates to compounds of general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use as modulators in the preparation of medicaments for the treatment of menopausal symptoms, polycystic ovary syndrome, uterine fibroids, schizophrenia, irritable bowel syndrome, vasomotor symptoms, breast cancer and related conditions, wherein the substituents of general formula (I) are as defined in the description.

The purpose of the present invention is to provide a composition for preventing or ameliorating climacteric symptoms. The present invention relates to a composition for preventing or ameliorating climacteric symptoms, characterized by containing ergothioneine or a salt thereof as an active ingredient.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating climacteric-like symptoms as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials: prepared rehmannia root, Chinese yam, wine-processed fructus corni, fried spina date seed, moutan bark, gardenia, white paeony root, rhizoma alismatis, angelica sinensis, poria cocos, blighted wheat, radix bupleuri and honey-fried licorice root, and the traditional Chinese medicine composition has the effects of nourishing yin, tonifying kidney, clearing heat and soothing liver, can effectively treat climacteric-like symptoms, and almost has no influence on sex hormone level, so that the traditional Chinese medicine composition has no toxic or side effect. Compared with hormone replacement treatment medicines, the medicine is safer. Especially for tumor patients with climacteric-like symptoms after receiving ovarian function inhibition treatment, the traditional Chinese medicine composition can improve the symptoms and avoid tumor recurrence caused by estrogen fluctuation at the same time.

The invention discloses a preparation method and application of a medicine for preventing and treating premature ovarian failure, the medicine comprises the following components in parts by weight: 3-10 parts of eucommia ulmoides, 2-8 parts of salvia miltiorrhiza and 1-6 parts of ligusticum wallichii. The premature ovarian failure (POF) is also called ovarian insufficiency, refers to ovarian function decline, follicle-stimulating hormone level increase and estrogen level decrease of women before 40 years old, and shows secondary amenorrhea and infertility, and is often accompanied with menopausal symptoms such as sweating, insomnia, hypomnesis and the like in a night sleep process; at present, hormone replacement treatment is a main treatment method for premature ovarian failure, but the side effect is large after hormone is taken for a long time, and the probability of suffering from breast cancer and endometrial cancer can be increased; the medicine composition disclosed by the invention can be further developed into a molecular traditional Chinese medicine for preventing POF and delaying the POF process, so that the comprehensive utilization of the composition is promoted, and a new choice is provided for patients with POF.

The technical problem of the present invention is to provide a composition for improving fatigue, sleep disorder or asthenopia and climacteric symptoms. The technical problem is solved by a composition containing lactobacillus plantarum L-137.

The present invention discloses a probiotic composition for improving menopausal symptoms and its application, which combines raw materials of both medicine and food with probiotics complementing each other, having a simple composition and synergistic effect, being rich in various essential nutrients and trace elements for the human body, and having the functions of strengthening the spleen and stomach, nourishing the liver and kidney, and calming the nerves, and can improve symptoms such as hot flashes and sweating, insomnia and dreaminess during menopause. The present invention can be used to improve menopausal syndrome, expanding the application field of probiotics.

1. A drug delivery device for use in treating one or more menopausal symptoms in a subject, comprising intravaginal insertion of an indwelling drug delivery device into the subject, wherein the drug delivery device comprises an estrogen and a progestin, and further provides a baseline-adjusted steady-state plasma estrogen concentration in the subject of about 15 pg / mL to about 50 pg / mL.

The invention discloses a general climacteric medicinal and edible comprehensive conditioning formula which comprises the following components: donkey-hide gelatin, codonopsis pilosula, ginseng, astragalus membranaceus, roses, lucid ganoderma, sanchi flowers, lotus seeds, Chinese wolfberry fruits and filling seasonings. The ubiquitous climacteric medicinal and edible comprehensive conditioning powder can achieve a comprehensive conditioning and nourishing effect, realizes multiple effects of improving sleep, regulating emotion, increasing vitality and the like through a formula product, and has an obvious nourishing effect on climacteric symptoms; compared with traditional Chinese medicine and health-preserving tea, a boiling process is omitted, the superfine powder is more convenient to brew and eat, flower fragrance and fruit fragrance are added to the taste, sugar substitutes are used for adjustment, and compared with bitter and astringent beverages such as traditional Chinese medicine herbal tea, the taste is easier to accept, and the experience is better.

The invention relates to a method for treating or preventing cognitive menopause symptoms. The method comprises administering to a human female suffering from or at risk of the cognitive menopause symptom an effective amount of an isoflavone source in combination with at least one of a natural extract for supporting cognitive performance and a natural extract for promoting calm and alleviating tension. The combination may be administered in a composition further comprising one or more of vitamin B12, vitamin B6, vitamin B complex, iron, magnesium, and / or a freshener / cooling agent. A single or multiple doses of the composition may be administered per day, the multiple doses including a first dose and a second dose. A first dose may be administered to the human female in the morning and a second dose may be administered to the human female at night.

The present invention relates to a therapeutic agent for osteoporosis and plantar fasciitis, and a method for manufacturing the same, the therapeutic agent for osteoporosis and plantar fasciitis comprising: pine root (pine root peak), Coriolus versicolor (Ganoderma lucidum in thousand years), Agaricus farnesii (Agaricus farnesii), Trametes versicolor (Trametes versicolor), Sorbus pohuashanensis, Phellinus linteus (Phellinus linteus), Vitex negundo petals, Vitex negundo leaves, and distilled liquor. The present invention has the effects of reducing the bone mineral density decrease rate or increasing the bone mineral density of osteoporosis patients, significantly improving the heel pain of plantar fasciitis patients, improving the cognitive ability of senile dementia, and relieving various female climacteric symptoms.

The present disclosure relates to a composition for treating or alleviating female menopausal symptoms, which contains a mixed extract of hop and citrus peel as an active ingredient, and a method for treating or alleviating menopausal symptoms. The composition of the present disclosure has superior effect of alleviating or treating female menopausal symptoms, particularly cardiovascular disease and / or osteoporosis.

The invention discloses a functional food composition for improving haggard face and replenishing qi and blood. The functional food composition comprises the following materials in parts by weight: 2-550 parts of ginseng, 3-500 parts of angelica, 3-550 parts of mulberry, 2-500 parts of raspberry, 2-500 parts of wolfberry, 3-550 parts of cassia seed, 3-550 parts of polygonatum, 2-500 parts of polygonatum, 2-400 parts of sophora japonica flower, 3-550 parts of longan pulp, 2-400 parts of platycodon, 2-550 parts of tangerine peel, 3-550 parts of dandelion, 1-250 parts of rose, 1-550 parts of chrysanthemum procumbens, 2-250 parts of loquat leaf, 2-500 parts of burdock root, 2-250 parts of emblica fruit, 2-250 parts of bamboo leaf, 2-250 parts of dried ginger, and 2-250 parts of donkey-hide gelatin. The invention also discloses a preparation method of a functional food composition for improving haggard appearance and replenishing qi and blood.