18 results about "Menopausal Symptom" patented technology

Aspects of disclosure relate to a composition and methodology for treating menopause symptoms utilizing a cannabinoid-based nanoplatform composition. The composition includes phytocannabinoids like CBD, CBG, and CBN, alongside isoflavones and polyphenols, all integrated into nanoplatform designed for enhanced bioavailability and controlled release. The formulation is designed to alleviate key menopause-related issues, including vasomotor symptoms (VMS), genitourinary syndrome of menopause (GSM), bone loss, mood disturbances, and sleep disorders, while addressing cardiovascular disease (CVD) risks. The composition combines cannabinoids, such as CBD, with isoflavones and polyphenols, and is incorporated into nanoplatforms for enhanced delivery and efficacy. Additionally, the disclosure includes a kit comprising oral capsules, intravaginal ovules, and instructions for use. The capsules contain a blend of cannabinoids, flavonoids, and polyphenols, while the ovules are composed of CBD and cocoa butter. The kit provides a comprehensive solution for managing menopause symptoms and mitigating cardiovascular risks.

The invention belongs to the field of traditional Chinese medicines, and provides application of a valerian extract in preparation of a medicine for preventing and treating climacteric syndrome. Pharmacological experiments show that the valerian extract has a regulation effect on a hypothalamic-pituitary-neuroendocrine system, and has important significance in regulating postmenopausal endocrine conditions of middle-aged and old women and improving anxiety, insomnia, dysphoria and other climacteric symptoms related to FSH (follicle stimulating hormone) and LH (luteinizing hormone). In addition, the valerian extract has a good regulation effect on secretion of related sex hormones and hypothalamus neurotransmitters of climacteric rats, and has a certain correction effect on the central monoamine neurotransmitter disorder state of the climacteric rats. The traditional Chinese medicine composition can improve clinical symptoms of climacteric syndrome.

This invention relates to the use of compounds represented by Chemical Formula 1 and / or compounds represented by Chemical Formula 2, or salts of compounds represented by Chemical Formula 1 and / or salts of compounds represented by Chemical Formula 2, in the manufacture of compositions for the treatment, prevention, or improvement of menopausal symptoms in women, wherein the compositions comprise compounds represented by Chemical Formula 1 and / or compounds represented by Chemical Formula 2, or salts of compounds represented by Chemical Formula 1 and / or salts of compounds represented by Chemical Formula 2, Chemical Formula 1 Chemical Formula 2:

Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including in overweight or obese subjects. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation or symptoms of menopause, including in overweight or obese subjects.

The method treats or prevents menopausal symptoms in cognitive function, and includes administering to a human female experiencing or at risk of menopausal symptoms in cognitive function an effective amount of a combination of an isoflavone source and at least one of a natural extract for supporting cognitive performance and a natural extract for promoting calmness and reducing stress. The combination may be administered in a composition further comprising one or more of vitamin B12, vitamin B6, a vitamin B complex, iron, magnesium, and / or a cooling / cooling agent. A single dose or multiple doses of the composition may be administered per day, with the multiple doses including a first dose and a second dose. The first dose may be administered to the human female in the morning, and the second dose may be administered to the human female in the evening.

The invention relates to application of ergothioneine in preparation of a preparation for improving an ovarian reserve function. The invention creatively discovers that the ergothioneine has the function of improving the ovarian reserve function, and the obvious clinical value of the ergothioneine for people with the serum AMH level of 1.0-3.0 ng / mL in the key'window phase 'is defined for the first time. The ergothioneine not only can improve the serum AMH level and the sinus follicle count (AFC), but also can significantly reduce the abnormally increased FSH and LH levels. Meanwhile, aiming at bone loss caused by ovarian reserve function decline, the ergothioneine shows an excellent bone quality protection effect, the bone density can be improved, and the thickness and number of bone trabecula can be increased. In addition, the ergothioneine can improve climacteric symptoms, effectively maintain the nutritional state of target organs such as uterus, delay atrophy and regulate menstrual cycle disorder.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, the described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. More preferably, the modified oil phase droplets of the MOIW microemulsion directly solubilize nonderivatized hormones. The oil phase droplets of the MOIW microemulsion include DHEA, pregnenolone, and a polyphenol, where a ratio of DHEA to polyphenol is from 1:1 to 12:1 by weight. Methods of supporting and / or increasing bloodstream hormone levels in perimenopausal and postmenopausal females and improving menopausal symptoms also are disclosed.

This document discloses compositions comprising one or more polyglutamic acid compounds. These compositions are used to treat, improve, prevent, or alleviate symptoms of vaginal dryness and menopausal symptoms. This document also describes compositions for treating, improving, preventing, or alleviating other dry skin symptoms on the body, extremities, hands, feet, neck, or face in subjects of all ages and sexes. This document also describes topical and suppository formulations of the compositions.

The invention discloses a composition of plant extracts capable of taking effect quickly and probiotics capable of taking effect for a long time and application of the composition of the plant extracts capable of taking effect quickly and the probiotics capable of taking effect for a long time. The composition comprises a first composition which takes effect quickly, further comprises a plant extract and a second composition which takes effect for a long time, and further comprises one or more of probiotics, prebiotics and metabiotics. The first composition and the second composition are used for improving digestive system functions, enhancing intestinal barriers, enhancing immunity, improving mood, relieving pressure and anxiety, improving female health, relieving climacteric symptoms, improving uncomfortable symptoms in the menstrual period, controlling and managing body weight and improving oral health through a synergistic effect.

The present invention relates to benzothiophene derivatives modulators, processes for their preparation and use. In particular, the present invention relates to compounds of general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use as modulators in the preparation of medicaments for the treatment of menopausal symptoms, polycystic ovary syndrome, uterine fibroids, schizophrenia, irritable bowel syndrome, vasomotor symptoms, breast cancer and related conditions, wherein the substituents of general formula (I) are as defined in the description.

1. A drug delivery device for use in treating one or more menopausal symptoms in a subject, comprising intravaginal insertion of an indwelling drug delivery device into the subject, wherein the drug delivery device comprises an estrogen and a progestin, and further provides a baseline-adjusted steady-state plasma estrogen concentration in the subject of about 15 pg / mL to about 50 pg / mL.

The invention discloses a general climacteric medicinal and edible comprehensive conditioning formula which comprises the following components: donkey-hide gelatin, codonopsis pilosula, ginseng, astragalus membranaceus, roses, lucid ganoderma, sanchi flowers, lotus seeds, Chinese wolfberry fruits and filling seasonings. The ubiquitous climacteric medicinal and edible comprehensive conditioning powder can achieve a comprehensive conditioning and nourishing effect, realizes multiple effects of improving sleep, regulating emotion, increasing vitality and the like through a formula product, and has an obvious nourishing effect on climacteric symptoms; compared with traditional Chinese medicine and health-preserving tea, a boiling process is omitted, the superfine powder is more convenient to brew and eat, flower fragrance and fruit fragrance are added to the taste, sugar substitutes are used for adjustment, and compared with bitter and astringent beverages such as traditional Chinese medicine herbal tea, the taste is easier to accept, and the experience is better.

The present disclosure relates to a composition for treating or alleviating female menopausal symptoms, which contains a mixed extract of hop and citrus peel as an active ingredient, and a method for treating or alleviating menopausal symptoms. The composition of the present disclosure has superior effect of alleviating or treating female menopausal symptoms, particularly cardiovascular disease and / or osteoporosis.

The invention relates to corn capable of improving the sex hormone level. The mass ratio of campesterol to stigmasterol to beta-sitosterol in the corn is 1: (0.5-5): (1-5). The corn can significantly improve the sex hormone level, thicken the vaginal mucosa, significantly reduce the pathological score and effectively relieve the climacteric symptoms of patients, and has the advantages of high yield of planted corn and corn straw, good taste, convenience in use, high bioavailability, safety, effectiveness, high comprehensive utilization rate of resources, environmental protection and the like.

Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, the described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. More preferably, the modified oil phase droplets of the MOIW microemulsion directly solubilize nonderivatized hormones. The oil phase droplets of the MOIW microemulsion include DHEA, pregnenolone, and a polyphenol, where a ratio of DHEA to polyphenol is from 1:1 to 12:1 by weight. Methods of supporting and / or increasing bloodstream hormone levels in perimenopausal and postmenopausal females and improving menopausal symptoms also are disclosed.

The present application relates to the technical field of microorganism and fermentation engineering, and particularly to a lactobacillus plantarum strain and a method for preparing a traditional Chinese medicine fermented beverage. The strain has been preserved in the Guangdong Microbial Culture Collection Center on December 13, 2024, and the preservation number is CGDMCC NO: 65639. The present application provides a method for preparing a blood supplementing beverage by fermentation using the strain. The method comprises mixing a traditional Chinese medicine extract, a ginseng concentrate and a pomegranate concentrate to obtain a mixed liquid, and then inoculating lactobacillus plantarum YXLP-116 for fermentation. The fermented beverage has the effects of regulating endocrine, improving reproductive health and relieving menopausal symptoms. Experimental results show that the beverage can significantly reduce the levels of FSH and LH, and increase the level of E2, and has high safety and cell protection effects. Animal experiments further confirm the potential of the beverage in regulating endocrine.