42 results about "Hypothalamus" patented technology

The invention belongs to the field of biotechnology and nutritional medicine, relates to a maternal obesity intervention preparation, and particularly relates to a preparation method of a plant embryo fermentation product and application of the plant embryo fermentation product in blocking of trans-generation delivery metabolic diseases. FWG is prepared through a probiotic fermentation technology, obesity, glucose and lipid metabolism disorder and oxidative stress induced by high-fat diet of a parent body can be remarkably improved, and cross-generation transmission of metabolic diseases is blocked by adjusting composition of intestinal flora of the parent body and offspring and a hypothalamic PI3K-Akt signal channel. The invention reveals that maternal FWG intervention passes through a mechanism that a PI3K-Akt pathway is dominated and multiple pathways are coordinated on the transcriptome level for the first time, the HFD-induced offspring hypothalamus metabolism programming abnormality is reversed, and a new central regulation target is provided for cross-generation metabolic disease prevention. The FWG is a wheat processing byproduct, is free of chemical additives, is suitable for long-term dietary supplement, is a natural and safe nutrition intervention scheme, and is suitable for the field of maternal and infant health.

The invention relates to application of bifidobacterium animalis subsp. Lactis BLa80 in preparation of a preparation for relieving depression or anxiety. The bifidobacterium animalis subsp. Lactis BLa80 is a strain of the bifidobacterium animalis subsp. Lactis BLa80 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.22547, and the strain of the bifidobacterium animalis subsp. Lactis BLa80 is a strain of the bifidobacterium animalis subsp. Lactis BLa80 with the preservation number of CGMCC No.22547. The invention develops a brand new application of the bifidobacterium animalis subsp. Lactis BLa80 strain, namely, the bifidobacterium animalis subsp. Lactis BLa80 strain is used for relieving depression or anxiety symptoms, specifically, the bifidobacterium animalis subsp. Lactis BLa80 strain can stimulate RIN14B cells to secrete 5-HT, can relieve depression and anxiety-like behaviors of mice suffering from depression and anxiety, can relieve hyperfunction of hypothalamic-pituitary-adrenal axis (HPA axis), and can relieve depression and anxiety-like behaviors of mice suffering from depression and anxiety. The inflammatory response of mice with depression and anxiety is relieved, the expression level of brain-derived neurotrophic factors in hippocampus of the mice with depression and anxiety is improved, the abundance of intestinal beneficial flora of the mice with depression and anxiety is improved, and the diversity of intestinal flora is increased.

The invention relates to the technical field of animal husbandry, in particular to a synchronous oestrus-timing insemination method suitable for cattle, which comprises the following steps: firstly, performing intramuscular injection of PG (cloprostenol sodium) at different time points after calving to promote uterine recovery and luteolysis and lay a synchronous oestrus foundation; the method comprises the key steps that GnRH (gonadotropin release hormone) is given through intramuscular injection on the 43rd day, the 53rd day, the 60th day and the 69th day, pituitary is promoted to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), collection and screening of follicles are guided, follicle maturation is promoted, the oestrus uncovering rate and the oestrus conception rate are increased, a melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day, and the melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day. The synthesis of ovarian hormones is promoted by regulating the hypothalamus-pituitary-gonad axis, the secretion of follicle cell factors and maturation promoting factors is promoted, the development of granular cells is promoted, and the maturation of oocytes is promoted. According to the method, the pregnancy rate of a double-synchronization-timing insemination scheme which is most widely used in a large-scale dairy cow breeding pasture at present can be remarkably increased, and feasible technical support is provided for success of increasing the breeding efficiency of cows.

This invention discloses a traditional Chinese medicine composition for improving hypertension, belonging to the field of traditional Chinese medicine compound preparation technology. This invention targets the core pathogenesis of hypertension caused by phlegm-dampness obstruction and peripheral microcirculation disorders, leading to abnormal activation of the hypothalamic-sympathetic-cardiac axis and compensatory cardiac hypertensive. The treatment principle is to resolve phlegm and dampness, and invigorate blood circulation. It is formulated with nutmeg, allium macrostemon, amomum villosum, peach kernel, safflower, platycodon grandiflorus, angelica dahurica, and tangerine peel. This combination can dredge the meridians, improve peripheral blood supply, and alleviate cardiac compensatory pumping, thus addressing hypertension caused by phlegm-dampness obstruction at its root. The formula is scientifically formulated, highly safe, and easy to prepare, making it suitable for long-term treatment and industrial promotion.

This invention discloses the application of ethinylestradiol and drospirenone in the preparation of drugs for treating post-traumatic stress disorder (PTSD). Ethinylestradiol, as an estrogen receptor agonist, regulates the hypothalamic-pituitary-gonadal axis and is used to treat female hypogonadism, menopausal syndrome, and advanced breast cancer, often in combination with progestins as oral contraceptives. The use of drospirenone and ethinylestradiol tablets (II) after induced abortion can shorten vaginal bleeding time, promote endometrial repair, and reduce the incidence of postoperative complications and repeat miscarriages. This invention has found that ethinylestradiol and drospirenone can reverse the abnormal decrease in hormones and neurosteroids caused by PTSD after spontaneous abortion, particularly the abnormal decrease in serotonin and tetrahydroprogesterone.

The invention relates to the technical field of traditional Chinese medicine extracts, in particular to an application of a ligusticum wallichii alcohol extract and an active monomer thereof in preparation of a product for relieving or treating food-borne obesity. Experimental research finds that when the ligusticum wallichii alcohol extract is singly used, the mRNA expression level of POMC in hypothalamus of a high-fat diet induced food-borne obesity mouse can be reduced, the alpha-MSH level in the hypothalamus can be improved, appetite can be effectively inhibited, body weight can be reduced, meanwhile, the number of lipid droplets in the liver can be reduced, and the ligusticum wallichii alcohol extract has the effects of relieving and treating food-borne obesity, preventing and treating hyperlipidemia and the like. And the application potential of liver tissues is improved, and a new direction and theoretical support are provided for treating food-borne obesity and expanding the medication range of ligusticum wallichii.

Combination therapies comprising oxytocin and gonadotropin releasing hormone are provided. The combinations can be used to treat aging-related neurological diseases or disorders. In addition, downstream effectors of OXT-GnRH combination, including hypothalamic stem / progenitor cells-derived EVs and vesicles containing or loaded with PTMS, can be used to treat aging-related neurological diseases or disorders.

The present application relates to the technical field of bioactive peptides, and in particular to an oat oligopeptide, preparation thereof and application thereof in preparing a product for regulating the expression of brain appetite suppressor factor. The oat oligopeptide can effectively stimulate the release of cholecystokinin (CCK) from intestinal endocrine cells, and stimulate the central nervous system through the vagus nerve pathway, thereby promoting the expression of the appetite suppressor factor pro-opiomelanocortin (POMC) in the hypothalamus. Compared with the prior art, the oat oligopeptide has the advantages of stable structure, high safety, simple preparation process (conventional enzymatic hydrolysis and chromatographic purification can achieve the preparation), easy scale production and the like. The oat oligopeptide is suitable for being used as a functional ingredient or a drug precursor to develop a related health product with the functions of regulating appetite and promoting satiety, and has a wide application prospect in the field of preparing functional products (food, medicine and the like).

Provided are cortical interneurons and other neuronal cells and in vitro methods for producing such cortical interneurons and other neuronal cells by the directed differentiation of stem cells and neuronal progenitor cells. The present disclosure relates to novel methods of in vitro differentiation of stem cells and neural progenitor cells to produce several type neuronal cells and their precursor cells, including cortical interneurons, hypothalamic neurons and pre-optic cholinergic neurons. The present disclosure describes the derivation of these cells via inhibiting SMAD and Wnt signaling pathways and activating SHH signaling pathway. The present disclosure relates to the novel discovery that the timing and duration of SHH activation can be harnessed to direct controlled differentiation of neural progenitor cells into either cortical interneurons, hypothalamic neurons or pre-optic cholinergic neurons. The present disclosure also relates to compositions of cortical interneurons, hypothalamic neurons or pre-optic cholinergic neurons, and their precursors, that are highly enriched and can be used in variety of application. These cells can be used therapeutically to treat neurodegenerative and neuropsychiatric disorders, and can be used for disease modeling and drug screening.

This invention discloses a traditional Chinese medicine composition for assisting in the improvement of hand-foot-mouth disease in infants and young children, belonging to the field of traditional Chinese medicine technology. The composition consists of eight medicinal herbs: lotus leaf, coix seed, angelica dahurica, kudzu root, platycodon root, agastache rugosa, cimicifuga rhizome, and dandelion, with a defined optimal medicinal ratio. Based on the seasonal differences in the pathogenesis of hand-foot-mouth disease, this invention targets the core pathologies of winter (cold congestion of microvessels, water and sodium retention, and internal heat generation) and spring and summer (hypothalamic sympathetic activation, increased heart rate, and visceral heat overload). It also addresses the technical deficiencies of clinical Western medicine, cold-natured traditional Chinese medicine, calamine lotion, and diuretics, such as vasoconstriction, kidney damage, central nervous system disorders, increased skin exudation, and rebound water retention. This invention employs a combination of warming and cooling herbs, regulating the ascending and descending functions, and promoting diuresis and protecting the body's vital energy. The synergistic effects of these herbs can dilate spasmodic microvessels, improve renal perfusion, stabilize abnormal heart rates, stabilize the hypothalamic center, and assist in antagonizing enteroviruses. By targeting and reducing abnormal permeability of skin capillaries with Angelica dahurica and Platycodon grandiflorus, it reduces blood extravasation and inhibits the formation and exudation of herpes from the root cause. This invention has mild medicinal properties, is suitable for all seasons, and has high safety. It can effectively improve symptoms of hand-foot-mouth disease such as fever, herpes, irritability, and cold extremities, reduce the risk of severe illness, antagonize the toxic side effects of commonly used clinical drugs, and is suitable for the delicate constitution of infants and young children, possessing good prospects for clinical application and promotion.

Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose tissue which has extensive communication with other organs, particularly with the brain through the sympathetic nervous system (SNS). Our study reveals a new light-triggered crosstalk between adipose tissue and the hypothalamus. Direct blue-light exposure to subcutaneous white fat improves high-fat diet-induced metabolic abnormalities in an Opsin3-dependent manner. Metabolomic analysis shows that blue light increases circulating levels of histidine, which activates histaminergic neurons in the hypothalamus and stimulates brown adipose tissue (BAT) via SNS. Blocking central actions of histidine and denervating peripheral BAT blunts the effects of blue light. Human white adipocytes respond to direct blue light stimulation in a cell-autonomous manner, highlighting the translational relevance of this pathway. Together, these data demonstrate a light-responsive metabolic circuit involving adipose-hypothalamus communication, offering a potential strategy to alleviate obesity-induced metabolic abnormalities.

The invention discloses an application of bifidobacterium animalis subsp. Lactis SS9 in preparation of a product for preventing and treating stress obesity. The bifidobacterium animalis subsp. Lactis SS9 obtained by screening can remarkably relieve obesity induced by combination of chronic pressure and high-fat diet, and the obesity is represented by slowing down weight increase, reducing appetite, improving blood fat, up-regulating GLP-1 and insulin secretion and effectively relieving anxiety-like and depression-like behaviors. Researches find that the strain can regulate the hypothalamic-pituitary-adrenal axis activation level, improve secretion imbalance of hormones such as CRH, ACTH and CORT, restore expression of appetite regulation factors such as NPY / AgRP / POMC of hypothalamic and relieve emotional eating behaviors. In addition, the strain can also reduce the systemic inflammation level, recover the diversity of intestinal flora and improve the proportion of beneficial bacteria. The invention provides the probiotics with multiple effects of regulating emotion, controlling body weight and improving metabolic disorder, and a new strategy is provided for preventing and treating stress-related obesity.

The invention provides an essential oil composition for relieving depressive symptoms and a preparation method and application thereof, and belongs to the technical field of essential oil compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 1-9 parts of perilla frutescens, 1-9 parts of rhizoma cyperi, 1-9 parts of pericarpium citri reticulatae and 1-9 parts of liquorice. The essential oil composition provided by the invention has a kidney channel protection effect, can reduce the rising corticosterone level in the body, alleviates the neuroendocrine dyscrasia related to depression by adjusting the hypothalamus-pituitary-adrenal axis (HPA axis) function, and can improve the appetite and metabolic state of the body at the same time.

The invention belongs to the technical field of PCOS infertility intervention, and particularly discloses angle-adjustable PCOS endocrine regulation glasses and method based on an AI algorithm, the glasses comprise a glasses frame and a glasses bracket, an adjustable light plate is hinged to the glasses frame, an intervention light source is integrated on the inner side of the adjustable light plate, and the irradiation angle of the light source is adjusted through rotation of the adjustable light plate; a pupil distance sensor is arranged on the inner side of the adjustable light plate, a control module is arranged in the lens frame, an AI algorithm is arranged in the control module, target light intensity parameters are calculated through a preset mathematical model, a light source is finely adjusted, and therefore it is ensured that the light intensity accurately acts on a retina target area, and hypothalamic repair hormone secretion is induced. The AI algorithm is linked with the angle of the adjustable light plate and the pupil distance to correct the light intensity in real time, it is ensured that the retina is accurately illuminated, and hypothalamus is effectively induced to repair hormone secretion so as to intervene in PCOS infertility.

The invention discloses a hypothalamic malocroma epilepsy subtype identification method based on an interpretable graph neural network, and belongs to the technical field of epilepsy diagnosis. The method comprises the following steps: acquiring a preoperative electroencephalogram signal of a hypothalamic malocclusion accompanied with epilepsy patient, and performing preprocessing and feature extraction to obtain time-frequency feature data; the method comprises the following steps of: firstly, acquiring a spatial topology feature, a multi-scale time-frequency feature and a dynamic time sequence feature of brain function connection through a main layer, a graph attention network module, a multi-scale frequency-time attention module and a bidirectional long-short-term memory network, and realizing subtype identification of the sphincter epilepsy and the non-sphincter epilepsy by cooperatively capturing the spatial topology feature, the multi-scale time-frequency feature and the dynamic time sequence feature of brain function connection; and finally, extracting an adjacent matrix after training convergence of the GAT module, and mining potential biomarkers through network topology quantitative analysis. The method breaks through the limitation of traditional subjective identification, improves the identification accuracy and stability through a multi-module collaborative architecture, provides an objective basis for clinic, and has an important clinical conversion value.

This invention discloses a traditional Chinese medicine composition for improving fever due to wind-cold and its application, belonging to the field of traditional Chinese medicine technology. Targeting the core pathogenesis of fever due to exogenous wind-cold, this invention combines modern thermoregulation and microcirculation pathological mechanisms, based on the principle of hypothalamic preoptic thermoregulatory center regulation. It abandons the drawbacks of Western medicine ibuprofen, which forcibly intervenes in the hypothalamic thermoregulatory center, constricts visceral blood vessels, and aggravates organ damage. It overcomes the technical defects of traditional Chinese medicine, which simply induces sweating to relieve exterior symptoms, depletes qi and damages yang, and easily leads to recurrence. The formula uses ephedra, curculigo, angelica pubescens, and galangal in combination. Through the synergistic effects of dispersing cold and clearing the lungs, warming yang and consolidating the collaterals, warming the middle jiao and dispelling pathogens, and unblocking the meridians, it gently regulates the homeostasis of the hypothalamic thermoregulatory center, expands spasmodic capillaries on the body surface and in the internal organs, improves the body's microcirculation, dispels cold pathogens from the skin surface, warms and unblocks the blood vessels of the internal organs, and also protects the heart, liver, and kidneys, strengthening the body's foundation and nourishing the vital energy. This achieves a comprehensive improvement of fever due to wind-cold, with mild medicinal properties, stable efficacy, and no risk of organ damage.

The invention discloses a method for inhibiting microglial cell activation through Mfn2. According to the method, expression of Mfn2 in microglial cells is up-regulated by applying lactic acid or analogues thereof, so that activation of an NF-kappa B inflammation pathway is inhibited, the mitochondrial function is improved, and then activation of the microglial cells is relieved. Experiments prove that lactic acid promotes Mfn2 expression through histone lactic acid modification (such as H3k18la), and high-intensity intermittent training (HIIT) can improve obesity-related hypothalamic inflammation and systemic metabolic disorder through the mechanism. The invention provides a new strategy for treatment of obesity and related metabolic diseases.

This invention provides for a method of treating secondary adrenal insufficiency by co-administrating therapeutically effective amounts of a glucocorticoid and a glucocorticoid receptor antagonist to the patient in need thereof. In some embodiments, the method includes the proviso that the patient not be otherwise in need of treatment with a glucocorticoid and a glucocorticoid receptor antagonist. The treatment method can increase the patient's morning or basal cortisol level to at least about 12 μg / dL or a standard control level, and in turn, expedite significantly the recovery of the HPA axis. The method provided herein can improve health outcomes and life-threatening complications associated with secondary adrenal insufficiency.

This invention discloses a training method for a central precocious puberty prediction model, belonging to the field of hypothalamic radiomics technology. The method includes: acquiring a sample set containing three-dimensional T1-weighted structural image data of historical samples and classification reference labels corresponding to each historical sample; segmenting the three-dimensional T1-weighted structural image data into hypothalamic subregions to obtain image data of the hypothalamic subregions; extracting features based on the image data of the hypothalamic subregions to obtain radiomics features of each historical sample, and constructing a feature matrix based on the radiomics features; inputting the feature matrix and the corresponding classification reference labels into a preset machine learning classifier for iterative training; and then using the trained classification prediction model to predict central precocious puberty. Through precise targeted segmentation based on hypothalamic subregions, early and highly sensitive capture of disease indicators is achieved.

The present invention provides a method of stratifying test subjects with Polycystic Ovary Syndrome (PCOS) into those that are expected to respond to therapeutic treatment with an inhibitor of hypothalamic-pituitary-adrenal axis activity, those that are expected to respond to therapeutic treatment with an AKR1C3 inhibitor, and those that are expected to respond to therapeutic treatment with a 5alpha-reductase inhibitor, the method comprising: (a) providing a test sample from a test subject with PCOS; (b) determining the concentration / level in the test sample of at least one ovarian androgen steroid and / or a derivative thereof, and at least one adrenal steroid and / or derivative thereof; and (c) using the results from (b) to predict if the subject will respond to therapeutic treatment with an inhibitor of hypothalamic-pituitary-adrenal axis activity, therapeutic treatment with an AKR1C3 inhibitor, or therapeutic treatment with a 5alpha-reductase inhibitor.

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for improving depression and a preparation method and application thereof, and the traditional Chinese medicine composition comprises the following raw materials: a spina date seed modified extract, cortex albiziae, vinegar-processed modified radix bupleuri, angelica sinensis, radix paeoniae alba, polygala tenuifolia, poria cocos and a functional additive. According to the invention, the spina date seed modified extract can tranquilize mind by nourishing the heart, calm the heart and calm palpitation, and effectively improve symptoms such as insomnia and anxiety accompanied by depression; the vinegar-processed modified radix bupleuri can soothe liver-qi stagnation and smooth qi activity, and plays a key role in liver-qi stagnation of the depression core pathogenesis; the pretreated cortex albiziae can relieve depression, calm the nerves, activate blood, diminish swelling and assist in improving accompanying symptoms such as blood stasis and qi stagnation; the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition, the traditional Chinese medicine extract, the radix angelicae sinensis, the radix paeoniae alba and other traditional Chinese medicinal materials have a synergistic effect, the hypothalamus-pituitary-adrenal axis function is improved through multi-target regulation of central neurotransmitters, the improvement effect on depressive symptoms is obviously improved, the compatibility of the medicinal materials is good, the synergistic effect is higher, and the traditional Chinese medicine composition can be widely applied to preparation of medicines or health care products for improving the depressive symptoms.

This invention relates to the field of closed-loop neuroelectromodulation technology, specifically disclosing a method and system for inner ear EEG closed-loop neuroelectromodulation targeting the hypothalamus. The method includes the following steps: acquiring multimodal physiological signals, extracting individual hypothalamic neural response fingerprints, and generating an initial personalized modulation model containing a hierarchical long short-term memory neural network; simultaneously acquiring inner ear EEG signals and the multimodal physiological signals, and extracting pure hypothalamic projection area EEG signals through a hardware-level stimulation artifact suppression circuit. In practical applications, the method provided by this invention, by extracting individual-specific neural response fingerprints and combining them with a hardware-level stimulation artifact suppression circuit, reduces the impact of individual physiological differences and physical interference from electrical stimulation on signal acquisition, thereby improving the objectivity of calculating the individual's relative hypothalamic functional comprehensive index.

A method and apparatus for manipulating a temperature set-point of a human or homeothermic-animal for increasing or decreasing the body temperature above or below the prevailing body temperature for therapeutic purposes. The method includes the steps of warming or cooling sphenoid sinuses remotely resulting in manipulation of the temperature of the pituitary gland without manipulation of the hypothalamus temperature which in turn results in manipulation of the body-temperature set-point and the body temperature manipulates accordingly to the new temperature set-point. A heat exchange medium can be used to warm or cool sphenoid sinuses and thus the pituitary gland. The heat exchange fluid can be liquid, or gas maintained at a predetermined temperature. Alternatively, a temperature-controlled probe can be used that upon contact with the sphenoid sinuses provides for the heat exchange.

Compositions and methods for treating one or more symptoms associated with vaginal atrophy or discomfort are disclosed. The compositions include an effective amount of one or more of the active agents selected from pectin (P), hyaluronic acid (HA), and collagen (Cg), in a pharmaceutically acceptable carrier, for vaginal delivery. The disclosed compositions are useful in treating one or more symptoms associated with vaginal atrophy. Example subjects include postmenopausal women or premenopausal women who experience these symptoms as a result of breastfeeding, intensive vaginal douching, cigarette smoking, autoimmune conditions such as Sjogren's syndrome, pathologic conditions such as diabetes, premature ovarian insufficiency, bilateral oophorectomy, ovarian failure due to radiation or arterial embolization, hypothalamic-pituitary disorders. Additionally, the disclosed compositions are useful in generally alleviating vaginal discomfort such as pH imbalance, vaginal dryness, burning, itching, vaginal discomfort, pain and burning when urinating, dyspareunia (painful sex), and spotting during intercourse.

Methods are described for differentiating stem and post-natal cells into sex hormone-producing cells that can be administered to a patient autologously or allogeneically in order to maintain in balance, or rebalance, their hypothalamic-pituitary-gonadal (HPG) axis.

Described herein is a new oral method for using MK-0677 for detecting growth hormone (GH) deficiency (GHD). Also described is a method of treating growth hormone (GH) deficiency (MD) in children with a functional hypothalamic-pituitary GH axis.

The invention discloses application of rubber tree seed oil in preparation of a product for improving or treating kidney-yang deficiency, and belongs to the technical field of medicines. The hevea brasiliensis seed oil can improve the levels of serum adrenocorticotropin releasing hormone, adrenocorticotropin and corticosterone by adjusting the hypothalamus-pituitary-adrenal axis function so as to improve the related signs of kidney-yang deficiency, such as intolerance of cold and liking warm, cold limbs, lassitude, reduced autonomous activity and the like. The invention further discloses a composition containing the hevea brasiliensis seed oil. The composition can be prepared into medicines, health-care foods or functional foods. The invention provides a new choice which is single in component, clear in mechanism, safe and effective for the treatment of kidney-yang deficiency.

The invention belongs to the technical field of biological medicine and functional food, and discloses a fermentation composition based on signal peptide induction, which is prepared by the following steps: step 1, mixing astragalus membranaceus, lotus leaf, poria cocos and pericarpium citri reticulatae according to the mass ratio of (3-5): (2-4): (2-3): (1-2) to prepare a compound raw material; the fermentation composition is remarkable in effect and multi-target, the food intake can be reduced by reducing mRNA expression of hypothalamus neuropeptide Y and rat-related peptide and increasing the content of glucagon-like peptide-1, lipid metabolism can be regulated and controlled by improving mRNA expression of liver farnesoid X receptors, AMP-dependent protein kinase and carnitine palmitoyl transferase-1, and the food intake can be reduced by increasing the content of glucagon-like peptide-1. The abundance of intestinal bifidobacteria can be improved, and the expression of brown fat heat production related genes is promoted to balance intestinal flora; the safety of the composition is subjected to dual verification of animal and crowd tests, the weight and blood fat indexes of obese rats and obese crowds are remarkably improved, and the liver and kidney functions are not damaged.

The invention discloses a method for simultaneously increasing the concentration of citalopram hydrobromide and serotonin in the hypothalamus of a rat, the method comprises the step of intragastric administration of citalopram hydrobromide and borneol to the rat, the dosage of citalopram hydrobromide is 2mg / kg, and the dosage of borneol is 30mg / kg. After citalopram hydrobromide and borneol are administered in the stomach, Cmax and AUC0-t of citalopram hydrobromide are remarkably increased, in addition, the ratio of 5-hydroxyindoleacetic acid to 5-hydroxytryptamine is remarkably reduced, and it is indicated that BO can more effectively enhance hypothalamic citalopram hydrobromide and serotonin in hypothalamic of a conscious rat.