The invention provides a traditional Chinese medicine composition for treating advanced breast cancer and a preparation method and application of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicine theory preparations. The traditional Chinese medicine composition comprises the following raw materials in parts by weight of 5-15 parts of ginseng, 20-40 parts of radix astragali, 10-30 parts of radix bupleuri, 5-15 parts of rhizoma pinelliae preparata, 10-30 parts of radix angelica sinensis, 10-30 parts of bighead atractylodes rhizomes,10-30 parts of poria cocos, 10-20 parts of thunberg fritillary bulbs, 5-15 parts of pseudobulbus cremastrae seu pleiones, 20-40 parts of fresh oyster shells, 10-30 parts of white peony roots, 10-30 parts of snakegourd fruits and 5-15 parts of prepared rhizoma arisaematis. A traditional Chinese medicine theory is used for guidance, soothing liver, regulating qi, replenishing qi to invigorate the spleen, dissipating phlegm and resolving masses are used as a treatment principle, the traditional Chinese medicine composition is used for treating advanced breast cancer (stagnation of liver qi, spleen deficiency and intermingled pathogenic phlegm and qi ), and the traditional Chinese medicine composition is mild in temperament, rigorous in compatibility, clear in pharmacodynamics substances, andnotable in clinical efficacy.