11 results about "Menopausal Syndrome" patented technology

This invention discloses the application of ethinylestradiol and drospirenone in the preparation of drugs for treating post-traumatic stress disorder (PTSD). Ethinylestradiol, as an estrogen receptor agonist, regulates the hypothalamic-pituitary-gonadal axis and is used to treat female hypogonadism, menopausal syndrome, and advanced breast cancer, often in combination with progestins as oral contraceptives. The use of drospirenone and ethinylestradiol tablets (II) after induced abortion can shorten vaginal bleeding time, promote endometrial repair, and reduce the incidence of postoperative complications and repeat miscarriages. This invention has found that ethinylestradiol and drospirenone can reverse the abnormal decrease in hormones and neurosteroids caused by PTSD after spontaneous abortion, particularly the abnormal decrease in serotonin and tetrahydroprogesterone.

The present invention relates to a nitrogen-containing heteropolycyclic derivative modulator, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof as a modulator in the preparation of drugs for treating menopausal syndrome, polycystic ovarian syndrome, uterine fibroids, schizophrenia, irritable bowel syndrome, vasomotor symptoms, breast cancer and related disorders thereof, wherein each substituent in general formula (I) is the same as defined in the description.

The application discloses a bird's nest compound product with the effect of improving female body health and a preparation method and application thereof. The preparation method comprises the following steps: mixing red ginseng, Gastrodia elata, ophiopogon, donkey-hide gelatin, eucommia and ganoderma lucidum with a solvent to form a mixed slurry; treating and extracting the mixed slurry by applying an electric field to prepare a compound liquid; and mixing the compound liquid with bird's nest to prepare the bird's nest compound product with the effect of improving female body health. The bird's nest is matched with the medicine-food homologous material, and on the basis of the theory of "suo zhuo jun chen", the bird's nest compound product capable of obviously improving menopausal syndrome is prepared, the hormone level is effectively adjusted, symptoms such as hot flashes, night sweats, sleep quality improvement, ovary and uterus repair promotion and the like are relieved, and the product is mild in action, high in safety, good in flavor and color.

The invention discloses a composition for regulating female endocrine and a preparation method thereof. Belongs to the technical field of biological medicine. The invention aims to solve the defects of female endocrine dyscrasia in the prior art, including unstable curative effect, slow effect, inconvenience in taking and the like, through the synergistic effect of specific components and an optimized preparation process. According to the composition, a prepared rehmannia root extract, a coptis chinensis extract, a white peony root extract, a scutellaria baicalensis extract, donkey-hide gelatin and poria cocos are taken as main active ingredients, oryzanol, vitamin B6 and 7-methylisonorethindrone are taken as auxiliary ingredients, and comprehensive regulation on female endocrine systems with climacteric and menopausal syndromes is realized through a scientific proportion and a unique preparation process. The components in the traditional Chinese medicine composition have a synergistic effect and comprehensively and accurately regulate endocrine, the core traditional Chinese medicine extracts are complementary, the endocrine dyscrasia mechanism is improved in a targeted manner, and the curative effect stability is guaranteed through scientific proportioning; the extraction process is optimized, and the utilization rate and activity of effective components are improved; the product form and the taking mode are optimized, the user compliance is improved, the multi-scene requirement is met, and the industrial pain point is solved.

The invention relates to a compound as shown in a formula (I), a stereoisomer, a tautomer, an isotope label, nitrogen oxide, a solvate, a polymorphic substance, pharmaceutically acceptable salt or prodrug of the compound, a preparation method of the compound, and a pharmaceutical composition of the compound and the stereoisomer, the tautomer, the isotope label, the nitrogen oxide, the solvate, the polymorphic substance and the pharmaceutically acceptable salt or prodrug. In particular, the compounds are NK-3 receptor antagonists, the compound can be used for preventing and / or treating depression, anxiety disorder, psychosis, schizophrenia, psychotic disorder, bipolar disorder, cognitive disorder, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorder, pain, convulsion, obesity, inflammatory diseases, vomiting, pre-eclampsia, airway-related diseases, reproductive disorders, contraception and sex hormone dependent diseases, and can be used for preventing and / or treating diseases such as chronic bronchitis and chronic bronchitis. , gynecological diseases, and climacteric syndrome.

The invention relates to a traditional Chinese medicine composition and a preparation method and application thereof, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition is prepared from thirty traditional Chinese medicine raw materials such as bull penis, cortex cinnamomi and alfalfa seeds and refined honey. The traditional Chinese medicine raw materials are crushed and mixed and then are prepared into honeyed boluses with the refined honey to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the effects of warming and nourishing brain and kidney, and benefiting heart and replenishing essence, and can be used for effectively treating impotence, depression, spermatorrhea, premature ejaculation, body deficiency, emaciation, neurasthenia, premature ovarian insufficiency, ovarian reserve hypofunction, climacteric syndrome, infertility and / or infertility. The dracocephalum moldavica, the anchusa, the chicory and the hawthorn are further added, so that the efficacy of treating the impotence can be improved, and the effect of treating the hyperlipidemia is achieved.

The application discloses a strain of Bifidobacterium adolescentis for relieving estrogen-related metabolic disorders and obesity and an application thereof, and belongs to the technical field of microorganisms. The Bifidobacterium adolescentis CCFM1506 screened by the application can effectively improve the symptoms of estrogen disorders of ovariectomized individuals, significantly slow down the weight growth rate and weight increment of individuals with estrogen disorders, increase the expression amounts of serum estradiol, CYP11A1 and ERa in adrenal glands and the high-density lipoprotein content in serum, reduce the total cholesterol and glucose levels, adjust abnormal glucose and lipid metabolism, increase SCFA in colon contents, relieve menopausal syndrome caused by the decrease of estrogen, and can be used for preparing medicines for relieving or treating estrogen-related metabolic disorders and obesity, or health care products for helping to control fat in the body and maintain the healthy level of blood lipids. The significant physiological effect and wide application prospect provide a new thought and new basis for developing functional foods or medicines based on probiotics.

The present application relates to a compound as shown in formula (I), stereoisomer, tautomer, isotopically labeled, nitroxide, solvate, polymorph, pharmaceutically acceptable salt or prodrug thereof, and preparation method and pharmaceutical composition. The compound is an NK-3 receptor antagonist, which can be used for preventing and / or treating depression, anxiety, psychosis, schizophrenia, psychotic disorder, bipolar disorder, cognitive disorder, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorder, pain, convulsion, obesity, inflammatory disease, vomiting, preeclampsia, airway related disease, reproductive disorder, contraception and sex hormone dependent disease, gynecological disease related disease, menopausal syndrome related disease.

The invention relates to a compound as shown in a formula (I), a stereoisomer, a tautomer, an isotope label, nitrogen oxide, a solvate, a polymorphic substance, pharmaceutically acceptable salt or prodrug of the compound, a preparation method of the compound, and a pharmaceutical composition of the compound and the stereoisomer, the tautomer, the isotope label, the nitrogen oxide, the solvate, the polymorphic substance and the pharmaceutically acceptable salt or prodrug. In particular, the compounds are NK-3 receptor antagonists, the compound can be used for preventing and / or treating depression, anxiety disorder, psychosis, schizophrenia, psychotic disorder, bipolar disorder, cognitive disorder, Parkinson's disease, Alzheimer's disease, attention deficit hyperactivity disorder, pain, convulsion, obesity, inflammatory diseases, vomiting, pre-eclampsia, airway-related diseases, reproductive disorders, contraception and sex hormone dependent diseases, and can be used for preventing and / or treating diseases such as chronic bronchitis and chronic bronchitis. , gynecological diseases, and climacteric syndrome.

The application discloses a preparation method for separating and extracting genistein from carob pods, and specifically comprises the following steps: rough powder of carob pods is extracted with 80-95% and 60-80% ethanol successively to obtain an extract, and the extract is adsorbed by macroporous adsorption resin D101 to obtain non-sugar small molecules; the non-sugar small molecules are successively extracted by petroleum ether and ethyl acetate, and are separated and purified by silica gel column, ODS, Sephadex LH-20 column chromatography and semi-preparative liquid phase to obtain high-purity genistein; and the high-purity genistein has the effect of regulating estrogen and improving menopausal syndrome.

The invention provides an application of a burdock extract and a composition thereof in preparation of a product for preventing, delaying or improving equol deficiency related diseases or symptoms, relates to the technical field of biology, and particularly relates to an application of a burdock extract in preparation of a product for preventing, delaying or improving equol deficiency related diseases or symptoms. In-vitro fermentation experiments prove that in a fermentation system containing daidzein and human intestinal flora, the burdock extract is added, so that the generation of equol can be remarkably promoted, and the yield of the burdock extract is remarkably improved compared with that of a positive control group only added with daidzein. The burdock extract is safe and natural in raw material and free of toxic and side effects, provides an effective intervention strategy for promoting human intestinal equol, and can be used for developing and preparing medicines, foods or health care products for preventing, delaying or improving equol deficiency related diseases or symptoms (such as climacteric syndrome, osteoporosis and hormone-dependent cancer risks).