5 results about "Senile vaginitis" patented technology

Provided is a Lactobacillus crispatus VB250, which is deposited in the China General Microbiological Culture Collection Center (CGMCC) on 20 February 2023, with the deposit number of CGMCC No.26574. The Lactobacillus crispatus provided in the present invention has good growth activity and multiple pathogenic bacteria inhibition activity in a low pH environment, and can be used for preventing and / or relieving and / or treating related diseases caused by vaginal flora disorder, such as bacterial vaginitis, colpitis mycotica, trichomonas vaginitis, aerobic vaginitis, senile vaginitis, and vaginitis caused by virus infection. Moreover, the Lactobacillus crispatus has great application prospects in preparation of products such as food, health-care food, drugs, and hygienic products.

The present invention relates to the use of lactic acid and / or lactic acid salts for the treatment and / or prevention of estrogen deficiency-related vaginal symptoms, urogenital menopausal syndrome, postmenopausal atrophic vaginitis, senile vaginitis, vulvovaginal atrophy and / or vaginal dryness in postmenopausal women.

This invention belongs to the field of biomedicine and discloses the application of HMOX1 inhibitors in the preparation of drugs for treating senile vaginitis. This invention is the first to discover that the content of the metabolite MESV1 (Guggulsterone) is significantly elevated in the vaginal secretions of patients with senile vaginitis. MESV1 induces ferroptosis in vaginal epithelial cells by upregulating HMOX1 protein expression, thereby driving the disease. Based on this, this invention proposes a novel therapeutic strategy targeting HMOX1. The inhibitors include shRNAs targeting HMOX1 (such as SEQ ID NO: 1-3), which can be prepared into vaginal gels, creams, and other dosage forms. Simultaneously, MESV1 can also be used to prepare auxiliary diagnostic kits. This invention provides a novel target and precise treatment approach for non-hormonal treatment of senile vaginitis.

The application relates to a shrinking and lubricating gel, which comprises the following raw materials in percentage by weight: xanthan gum 0.1-2%, trehalose 0.1-2%, carbomer 0.1-3%, glycerol 1-20%, gelatin alginate complex 1-10%, humectant 0.2-4%, disodium edetate 0.01-0.1%, polyethylene glycol 0.1-2%, pH regulator 0.1-3%, royal jelly extract 0-2%, schisandra extract 0-2%, and the balance is water. The application forms a protective biological gel layer on the vaginal wall through the lubricating gel, so as to prevent pathogenic microorganisms from planting, and is suitable for improving itching, erosion, burning, vaginal atrophy, sexual intercourse pain, senile vaginitis, abnormal leucorrhea, urinary urgency, dysuria and other menopausal reproductive urological syndromes.

The invention provides a female external nursing product with antibacterial, anti-inflammatory and antipruritic effects and a preparation method thereof, and relates to the technical field of biological medicine nursing products. The invention provides an external nursing product for women, which is prepared from the following pure traditional Chinese medicinal materials: cortex ailanthi, saururus chinensis, pericarpium granati, chingma abutilon seeds, red halloysite, lysimachia clethroides, gynura plicata, evodia lepta leaves, peach leaves, pine needles, water gossypium, solanum lyratum and cyrtomium fortunei as raw materials. The traditional Chinese medicine raw materials in the product are scientific in compatibility and have a synergistic effect, the product shows an ultra-excellent antibacterial effect on staphylococcus aureus, escherichia coli and candida albicans, meanwhile, the product has good anti-inflammatory and anti-inflammatory effects, can achieve rapid itching relieving, and in addition, the product has no stimulation effect on vaginal mucosa of female white rabbits and has good safety. The product disclosed by the invention can be used for effectively improving the symptoms such as itching and causalgia, peculiar smell and abnormal secretion caused by colpitis mycotica, bacterial vaginitis, trichomonas vaginitis, senile vaginitis and the like.