The invention discloses a preparation method of a Chinese medicine irrigation solution for treating urethral orifice burning type senile vaginitis, belonging to the technical field of preparation method of Chinese medicines. At present, generally, antibiotics and sulfanilamide medicines are used for treating urethral orifice burning type senile vaginitis, and the disadvantage is large toxic and side effect. The Chinese medicine irrigation solution disclosed herein is prepared by putting 38 kinds of herbs consisting of tartarian buckwheat root and rhizome, dandelion, dysosma versipelis, wikstroemia indica, saururus chinensis, radix berberidis, folium isatidis, garden euphorbia herb, Pennywort Herb, Rohdea japonica Roth, Aster ageratoides, radix sophorae tonkinensis, edible tulip, senecio scandens, Huperzia serrata, Japanese stephania root, thymifoious euphorbia herb, meadowrue root and rhizome, purslane, leaf of Chinese coriaria, ardisia crenata, centella asiatica, Polygonum hydropiper, sugarcane, HlblSClls llutabilis, sophora flavescens, balsam pear, ilex latifolia thumb, Elephantopus scaber, polygonum cuspidatum, saxifrage, folium phyllostachys and liquorice in water for soaking,then decocting with slow fire, filtering and removing the residues to obtain a liquid medicine. The Chinese medicine irrigation solution disclosed herein has the advantages of small toxic and side effect, short treatment course and high cure rate.