The application belongs to the technical field of biological
medicine, and relates to a herba
abutilon polysaccharide, a preparation method thereof and application thereof. The herba
abutilon is subjected to enzymolysis by using a composite
enzyme liquid containing
papain,
pectinase and
cellulase, and is subjected to ultrasonic extraction after the enzymolysis; the extraction liquid after extraction is purified and dried to obtain the herba
abutilon polysaccharide; wherein the
mass ratio of the
papain, the
pectinase and the
cellulase is (0.5-1.5):(0.5-1.5):(0.5-1.5), and the
enzyme dosage is 1-3% of the
mass of the herba abutilon. The herba abutilon
polysaccharide provided by the application has higher anti-inflammatory,
antioxidant, intestinal barrier repair and other effects, and can play the
efficacy of treating
ulcerative colitis through a multi-level
cascade action mechanism of'regulating intestinal
flora-promoting SCFAs generation-enhancing intestinal barrier-inhibiting inflammatory reaction'.