36 results about "Transdermal permeation" patented technology

The invention discloses a colchicine external preparation with high intradermal residual quantity and percutaneous transmittance as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The invention provides a colchicine external preparation with high intradermal residue and transdermal transmittance. The colchicine external preparation comprises: a) colchicine or a pharmaceutically acceptable salt thereof; b) a penetration enhancer; c) pharmaceutically acceptable excipients and / or excipients; the penetration enhancer is at least one of polyglycerol oleate or isosorbide dimethyl ether. The drug loading capacity and the percutaneous transmittance of the colchicine external preparation disclosed by the invention are remarkably improved. When polyglycerol oleate is selected as a penetration enhancer to prepare colchicine gel, the intradermal retention volume can reach 358.08 micrograms within 20 hours. When isosorbide monomethyl ether is selected as a penetration enhancer to prepare ethosome gel, the accumulated penetration amount can reach 106.87 mu g / cm < 2 >, and the intradermal residual amount can reach 90.58 mu g or above.

The invention discloses a drug-loaded protein-phospholipid composite nanoparticle as well as a preparation method and application thereof. The drug-loaded protein-phospholipid composite nanoparticle has a core-shell structure, an inner core comprises silk fibroin and a hydrophilic drug, a shell layer comprises a plurality of phospholipid bimolecular layers which are stacked layer by layer, each phospholipid bimolecular layer comprises soya bean lecithin, a hydrophobic drug is embedded in a hydrophobic region in each phospholipid bimolecular layer, and the hydrophobic drug is embedded in a hydrophobic region in each phospholipid bimolecular layer. Silk fibroin and a hydrophilic drug are embedded in the hydrophilic area, and zein and cholesterol are embedded in the phospholipid bilayer. The drug-loaded protein-phospholipid composite nanoparticle can simultaneously embed a hydrophobic drug and a hydrophilic drug, has the advantages of large drug loading capacity, high bioavailability, good stability, good transdermal permeation effect and the like, has wide application prospects in the fields of transdermal drug delivery preparations and skin care products, and is simple in preparation method, mild in reaction condition and suitable for industrial production. The method is suitable for large-scale industrial production and application.

The invention belongs to the technical field of medicine, and provides an external detumescence pharmaceutical composition and a preparation method thereof, the external detumescence pharmaceutical composition comprises, by weight, 18-22 parts of mirabilite, 0.05-0.15 part of borneol, 5-15 parts of schizonepeta volatile oil and 3-7 parts of angelica volatile oil. The herba schizonepetae volatile oil and the radix angelicae sinensis volatile oil which have the property of combining medicines with auxiliary medicines are creatively used for preparing the transdermal patch, so that the efficacy of the herba schizonepetae volatile oil and the efficacy of the radix angelicae sinensis can be exerted, and the herba schizonepetae volatile oil and the radix angelicae sinensis volatile oil cooperate with the mirabilite and the borneol to exert the curative effect, enhance the anti-inflammatory, swelling-relieving and pain-relieving effects, play a role in promoting permeation and enhance the transdermal permeation of effective components; the bioavailability is improved. The external detumescence pharmaceutical composition disclosed by the invention has a synergistic effect and remarkable anti-inflammatory and detumescence effects.

The invention discloses a metformin-loaded pegylated two-dimensional phosphorene nanosheet as well as a preparation method and an application of the metformin-loaded pegylated two-dimensional phosphorene nanosheet. The preparation method comprises the following steps: preparing two-dimensional phosphorene nanosheets from black phosphorus crystals through a liquid phase stripping method; the preparation method comprises the following steps: mixing polyethylene glycol amino with a two-dimensional phosphorene nanosheet to prepare a pegylated two-dimensional phosphorene nanosheet; the preparation method comprises the following steps: mixing metformin with the pegylated two-dimensional phosphorene nanosheet, and removing free metformin, so as to obtain the metformin-loaded pegylated two-dimensional phosphorene nanosheet. The metformin-loaded pegylated phosphorene nanosheet disclosed by the invention has transdermal permeation and anti-oxidative stress capabilities, can deliver a drug into skin tissues, induces angiogenesis of hair follicles and promotes hair regeneration of an androgenetic alopecia animal model by removing excessive ROS (reactive oxygen species) in the surrounding environment of the hair follicles, and is degradable, so that the metformin-loaded pegylated phosphorene nanosheet disclosed by the invention has a good application prospect. The compound is safe and low in toxicity, and has good clinical application prospect and development value.

The invention relates to the technical field of traditional Chinese medicine, in particular to traditional Chinese medicine meridian dredging massage cream and a preparation method thereof, myrrh (a monarch drug), kudzuvine root (a ministerial drug) and notopterygium root (an adjuvant drug) are used as core components, menthol, vanillyl butyl ether and other transdermal permeation enhancing systems are used as auxiliary materials, and an oil-in-water type microemulsion matrix is constructed. Through six innovations of'monarch-minister-assistant 'meridian targeted compatibility, three-dimensional transdermal permeation promotion and multi-component synergistic anti-inflammation, the effects of relaxing tendons, activating collaterals, dispelling wind and dissipating blood stasis are achieved. The preparation process adopts ultrasonic extraction and high-pressure homogenization technologies, and the integrity of active ingredients is reserved. The product is suitable for scenes such as cervical spondylosis, scapulohumeral periarthritis and rheumatic ostealgia and has the advantages of high transdermal efficiency, long-acting analgesia, good safety and the like, experimental verification shows that the transdermal amount within 24 hours is increased by 130%, the inflammatory factor inhibition rate reaches 89.2%, and the clinical effective rate is remarkably superior to that of commercially available products.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine essential oil microencapsulation transdermal absorption process. The core of the process is that a transdermal enhancer, traditional Chinese medicine essential oil and a wall material are synchronously added in an emulsification stage, a uniform emulsion system is formed through emulsification treatment, then curing treatment is performed to enable the wall material to be crosslinked to form microcapsules, and the microcapsules are separated, dried and dispersed in a matrix to prepare the transdermal preparation. According to the method, full integration of a transdermal enhancer and a microcapsule structure is realized, transdermal permeation of essential oil components is effectively promoted, meanwhile, the stability and biological activity of the essential oil are kept, and the clinical application value of the traditional Chinese medicine essential oil is improved.

The invention provides a traditional Chinese medicine composition with a function of dredging collaterals of muscles and bones, a traditional Chinese medicine ointment which comprises the traditional Chinese medicine composition and is used for preparing a plaster for dredging collaterals of muscles and bones and a preparation method of the traditional Chinese medicine ointment. According to the traditional Chinese medicine composition with the effect of dredging collaterals of muscles and bones, several Chinese herbal medicines are combined with a biological enzyme hydrolysis degradation technology; effective active ingredients, which cannot be directly utilized after entering a human body, in Chinese herbal medicines are hydrolyzed and degraded into small-molecule active substances such as oligosaccharide and oligopeptide which are easily dissolved in solvents such as water, alcohol or glycerol through biological enzyme, so that the small-molecule active ingredients in biological enzyme hydrolysate have a relatively strong transdermal permeation effect; according to the traditional Chinese medicine composition, pharmacodynamic molecules can be fully dissolved and easily absorbed by a human body, the pharmacodynamic effect is remarkably improved, meanwhile, the dissolving capacity of the traditional Chinese medicine composition in auxiliary materials can be enhanced, the pharmacodynamic effects of the Chinese herbal medicines are greatly improved, and meanwhile the effective treatment application dosage of the Chinese herbal medicines can be greatly reduced.

This invention provides tranexamic acid liposomes, their preparation method, and applications, relating to the field of nanoliposome technology. This invention utilizes a simple process to prepare tranexamic acid liposomes by rationally combining the ratios of tranexamic acid, phospholipids, and cholesterol. This invention achieves high loading capacity and high loading rate for the active ingredient tranexamic acid, maintaining its stability for a long time under various temperature conditions. The tranexamic acid liposomes prepared by this invention have a particle size between 10-50 nm, enabling better penetration into the stratum corneum and targeting the basal layer of the skin, providing a long-lasting and stable effect. Compared to liposomes prepared by other processes, they exhibit excellent transdermal permeability and skin retention, which is more conducive to the efficacy of the active ingredient, significantly improving its bioavailability and resulting in a greater skin-lightening effect.

A composition, method of treating inflammation or edema, and method of increasing transdermal permeation and flux of at least one cannabinoid is presented. The composition is comprised of at least one cannabinoid, at least one permeation enhancer and at least one hydrophilic polymer. Administration of a therapeutically effective amount of this composition of can be used to treat both inflammation and edema in a patient as well as increasing transdermal permeation and flux of the at least one cannabinoid.

The application discloses a quick and efficient melatonin transdermal delivery system, which is characterized by comprising the following structures arranged from top to bottom: at least one protective layer; at least one polymer base layer; and a multilayer structure of an anti-adhesion layer; wherein the polymer base layer comprises the following components by weight: compared with the prior art, the system has the following beneficial effects: compared with oral use of melatonin, the melatonin efficient delivery system reduces the dosage of melatonin by 50% to 400% and reduces side effects, and can improve the transdermal penetration rate of melatonin within the first two hours.

The present application relates to a kind of foam type cationic nanoemulsion hair lotion and its preparation method, belong to hair lotion technical field.The preparation method of the present application includes the following steps, S1, surfactant, oil phase material, co-surfactant and bacteriostatic agent are mixed uniformly, drug is added, heating is made to be fully dissolved, and oil phase is obtained;S2, oil phase is added dropwise into aqueous phase, essence is added, and the foam type cationic nanoemulsion hair lotion is obtained;The aqueous phase includes chitosan derivative and water.Utilize the positive electricity of chitosan derivative, make the charge of nanometer emulsion of surface negative charge reverse, make it and epidermal cell better interaction, reduce the amount of drug penetration, improve the amount of drug in skin retention, while chitosan derivative has strong permeability and adhesion, synergistic with foam agent improves the amount of drug in skin retention, prolongs the retention time of drug in vivo, increases the time of drug penetration effect, better play local effect.

According to the preparation method of the chlorogenic acid-methotrexate soluble microneedle, chondroitin sulfate and a methyl vinyl ether-maleic anhydride copolymer are adopted as matrix materials, and the drug-loaded microneedle is prepared through a two-step centrifugation method. The length of a needle body of the prepared microneedle is about 500 microns, the microneedle has good mechanical strength and skin puncture performance, the microneedle can be basically dissolved within 2 hours, the average drug content of chlorogenic acid is 57.97 + / -1.76 mu g / tablet, and the average drug content of methotrexate is 56.32 + / -1.67 mu g / tablet. An in-vitro percutaneous penetration test shows that the 6-hour cumulative transdermal rate of chlorogenic acid reaches 93.96%, the 6-hour cumulative transdermal rate of methotrexate reaches 86.92%, which are respectively 22.1 times and 3.0 times that of a control solution group, so that the efficient percutaneous delivery of the medicine is realized. The microneedle is small in skin irritation, the skin barrier can be naturally repaired within 15 minutes after puncture, and a new administration approach is provided for treatment of skin diseases such as psoriasis.

The invention relates to the technical field of cosmetics, in particular to a nano-coated alpha-arbutin deep eutectic and a preparation method and application thereof. The nano-coated alpha-arbutin deep eutectic is prepared from the following raw materials in parts by weight: 15 to 30 parts of soybean phospholipid, 4 to 10 parts of cholesterol, 1 to 5 parts of DSPE-PEG2000, 80 to 120 parts of choline chloride / alpha-arbutin DEA, 3 to 8 parts of trehalose and 3 to 8 parts of propylene glycol. Wherein choline chloride / alpha-arbutin DEA and alpha-arbutin form a stable deep eutectic through a hydrogen bond network by taking choline chloride as a hydrogen bond receptor, so that the problems of water solubility and photo-thermal instability of the deep eutectic are solved, and the transdermal permeation efficiency and the oxidation resistance are improved. Choline chloride / alpha-arbutin DEA is wrapped by nano-liposomes to form a physical barrier, so that external ultraviolet and high-temperature environments are avoided, the risk that the choline chloride / alpha-arbutin DEA is decomposed into hydroquinone is reduced, and the storage stability of active ingredients is prolonged.

The invention discloses a permeation-promoting and solubilizing meloxicam transdermal patch, and belongs to the field of pharmaceutics. The patch consists of a backing layer, a drug-loading pressure-sensitive adhesive layer and an anti-sticking layer, wherein the drug-loading pressure-sensitive adhesive layer consists of a solvent type pressure-sensitive adhesive, meloxicam, a penetration enhancer and a solubilizer. According to the patch, transdermal delivery of meloxicam is achieved, various penetration enhancers and solubilizers are systematically screened, so that meloxicam in the patch is continuously administered at a proper transdermal permeation rate, effective blood concentration can be maintained in a relatively prolonged time, the administration frequency is reduced, and the problem that the in-vitro accumulated permeation amount of the meloxicam patch is low is solved. The meloxicam patch has the characteristics of high percutaneous penetration amount and continuous administration, and is effectively used for skin administration treatment of osteoarthritis and rheumatoid arthritis.

The invention discloses an invisible flexible closed transdermal repair device, and belongs to the technical field of skin care devices. The device is formed by compounding an inner medicine contact layer, a middle flexible closed fitting layer and an outer simulation invisible shading layer, and can be applied to any skin part of the whole body of a human body. The inner layer is loaded with skin repairing active ingredients, so that continuous slow release and transdermal permeation of the medicine are realized; the middle layer is made of a flexible moldable material to form a closed microenvironment, so that water and medicine are locked, and the dry side effect of the medicine is counteracted; the outer layer has the full-shading performance and the skin simulation appearance, visual invisibility can be achieved, photosensitive component medicine can be protected to stably take effect in the daytime, and meanwhile cosmetic modification is supported. The device can automatically maintain skin micro-moisture balance, improves wearing comfort and long-term tolerance, is compatible with multi-scene hidden wearing such as daily make-up and social contact while efficiently repairing the skin, and is high in universality and wide in application prospect.

The invention discloses a double-drug-loading soluble microneedle patch with a hypertrophic scar improving function as well as a preparation method and application of the double-drug-loading soluble microneedle patch, and belongs to the technical field of medical cosmetology. The microneedle patch comprises a substrate and a needle body arranged on the surface of the substrate, wherein the needle body is mainly prepared from a cyclodextrin inclusion compound, colchicine and a microneedle framework material; the cyclodextrin inclusion compound is prepared from an insoluble drug shikonin and beta-cyclodextrin, and the microneedle framework material is prepared from sodium hyaluronate and polyvinylpyrrolidone. The double-drug-loading soluble microneedle patch has good mechanical strength and can accurately penetrate through scar skin to form a drug delivery channel. Compared with a traditional transdermal patch, the soluble microneedle has the advantages that the transdermal permeation efficiency of the medicine is greatly improved, and compared with traditional injection administration, the soluble microneedle reduces long-term irritation to the skin, reduces the risk of adverse reactions such as infection and bleeding and has a very good application prospect.

The application discloses a kind of total glycosides of Paeonia lactiflora and non-steroidal anti-inflammatory drug composition in transdermal drug preparation application.In transdermal drug preparation the application advantage of this composition is in:(1) the active epidermal barrier and stratum corneum barrier of skin is the main obstacle of total glycosides of Paeonia lactiflora transdermal absorption.The non-steroidal anti-inflammatory drug in the composition can reversibly open the active epidermal barrier of skin, if it is used with the skin stratum corneum barrier of penetration enhancer and can significantly improve the transdermal penetration performance of total glycosides of Paeonia lactiflora in this transdermal drug preparation, it is a kind of with simple preparation process, easy industrial production, skin non-invasive characteristics can safely, efficiently improve the method for the transdermal penetration ability of total glycosides of Paeonia lactiflora;(2) total glycosides of Paeonia lactiflora and non-steroidal anti-inflammatory drug combination in transdermal drug preparation, in the curative effect of treating primary dysmenorrhea and rheumatoid arthritis disease has obvious synergistic effect, curative effect is excellent.

The hydrogen percutaneous permeation device comprises a flat bag type gas diffuser, the bag type gas diffuser is communicated with one end of a gas guide pipe through a quick disassembly head, and the other end of the gas guide pipe is communicated with a pressure stabilizing gas supply unit; the pressure stabilizing air supply unit comprises an air cavity, the interior of the air cavity is divided into an air supply cavity and a pressure adjusting cavity through an extrusion diaphragm, an air outlet of the air supply cavity is communicated with the air guide pipe and used for conveying treatment air, and the pressure adjusting cavity is connected with the pressurizing mechanism which is used for pumping air into the pressure adjusting cavity. The extrusion diaphragm is pushed to deform so as to compress the volume of the air supply cavity; a pressure reduction unit is arranged on the gas guide tube and is used for controlling the pressure of the treatment gas conveyed to the bag type gas diffuser to be preset treatment pressure; the bag type gas diffuser is fixed to the periphery of the focus through the pressurization fixing assembly. The device does not need to be directly connected with a large external hydrogen source, and can provide a more efficient and convenient local treatment effect for a patient.

The invention discloses an application of a pharmaceutical composition consisting of total glucosides of paeony and a non-steroidal anti-inflammatory drug in a transdermal drug delivery preparation. The application of the composition in a transdermal drug delivery preparation has the advantages that (1) the active epidermal barrier and the cuticle barrier of the skin are main barriers of transdermal absorption of total glucosides of paeony; the non-steroidal anti-inflammatory drug in the composition can reversibly open the active epidermal barrier of the skin, and if the non-steroidal anti-inflammatory drug is matched with a penetration enhancer for opening the cuticle barrier of the skin, the transdermal permeability of the total glucosides of paeony in the transdermal drug delivery preparation can be remarkably improved; the method has the characteristics of simple preparation process, easiness in industrial production and non-invasive skin, and can safely and efficiently improve the percutaneous permeability of the total glucosides of paeony; and (2) the total glucosides of paeony and the non-steroidal anti-inflammatory drug in the transdermal drug delivery preparation are combined for use, so that the total glucosides of paeony and the non-steroidal anti-inflammatory drug have an obvious synergistic effect in the aspect of curative effect on primary dysmenorrhea and rheumatoid arthritis, and the curative effect is excellent.

The invention belongs to the technical field of pharmaceutical preparations, and relates to an olbucaine hydrochloride composition and application thereof. The olbucaine hydrochloride composition is prepared from the following components in parts by weight: 10 to 65 parts of olbucaine hydrochloride, 10 to 42 parts of penetration enhancer, 5 to 20 parts of pH (Potential of Hydrogen) regulator and 900 to 1000 parts of water. The olbucaine hydrochloride composition can significantly improve the percutaneous penetration efficiency of the medicine, improve the efficacy of superficial anesthesia, prolong the ejaculation time, and achieve the effect of preventing and treating premature ejaculation.

A preparation and a use of a nucleic acid with anti-hair loss and oil control effects and a composition including the nucleic acid are provided. The small interfering RNA (siRNA) sequence has a significant silencing effect for the androgen receptor (AR) target gene. The composition prepared from an ionic liquid or a combination of an ionic liquid and a lipid exhibits a prominent delivery effect for water-soluble nucleic acid molecules. The composition can penetrate cells and enter cell nuclei to achieve an AR-silencing effect, and can provide significant regulatory effects for downstream target genes or proteins regulated by AR and comprehensive anti-hair loss and oil control effects. The composition exhibits a prominent transdermal permeation-promoting effect, and can permeate the epidermis layer and reach the dermis layer to exert remarkable anti-hair loss and oil control effects. In addition, the composition has a high antibacterial activity against Propionibacterium acnes.

The present invention discloses a non-steroidal anti-inflammatory drug transdermal patch, which comprises a backing layer, a plaster layer and a release liner. The raw materials of the plaster layer are: indomethacin, amphiphilic cholesterol derivatives, isopropyl myristate, menthol, modified polyacrylate adhesive solution, tackifier, crosslinking agent, main drug solvent, wherein the modified polyacrylate adhesive solution uses ethyl acetate as a reaction solvent, and polyethylene glycol and zinc-based zeolitic imidazolate framework materials are respectively introduced during the polymerization of isooctyl acrylate, methyl acrylate and dimethylaminoethyl methacrylate; the present invention also discloses a preparation process of the non-steroidal anti-inflammatory drug transdermal patch. The non-steroidal anti-inflammatory drug transdermal patch of the present invention has air permeability, moderate adhesion, no skin irritation, can be administered locally, has a high transdermal permeation amount and a low residual drug amount, helps to improve the bioavailability and efficacy of the drug, and reduces the number of drug administrations and the drug dosage.

The invention relates to the technical field of transdermal drug delivery, and provides a compound ligustrazine transdermal patch and a preparation method and application thereof, and the compound ligustrazine transdermal patch is composed of ligustrazine, a polymer auxiliary material, a cosolvent, eugenol, a penetration enhancer, a pH regulator, an antioxidant and a preservative. Pharmacodynamic tests prove that ligustrazine and eugenol in the compound ligustrazine transdermal patch are combined for use, a remarkable synergistic effect is achieved, and the compound ligustrazine transdermal patch has a positive treatment effect on cerebral ischemia. According to the compound ligustrazine transdermal patch, the transdermal penetration amount of the medicine can be increased, the medicine can play a better role, and the utilization rate of the medicine is increased.

The present invention relates to a pharmaceutical composition for preventing or treating cancer, and preparation method therefor, the composition comprising a complex of a transdermal permeation peptide and a saccharide, and a lectin. It has been identified that, when the composition comprising the complex of the transdermal permeation peptide and the saccharide, and the lectin is used for cancer treatment, skin permeation of anticancer substances is improved, anti-tumor activity and anti-metastasis properties are exhibited, and hepatotoxicity is not exhibited, and thus effective use as a composition for anticancer treatment is possible.

The invention provides a traditional Chinese medicine composition with a vaginal tightening effect and a preparation method thereof, and further provides application of the traditional Chinese medicine composition in preparation of products for preventing or treating vaginal relaxation. According to the pharmaceutical composition with the vagina tightening effect, ten Chinese herbal medicines are combined with a special microbial fermentation technology, and effective active ingredients, which cannot be directly utilized after entering a human body, in the Chinese herbal medicines are degraded into small-molecule active substances through microbial fermentation, so that the efficacy of the ten Chinese herbal medicines is greatly improved; the micromolecular active ingredients in the fermentation product have a relatively strong transdermal permeation effect, and the content of fibroblast growth factors of vaginal cells can be increased, so that the content of collagen of the vaginal cells is increased, and the purpose of improving the contractility of vaginal muscle fiber cells is achieved.

The invention provides a high-efficiency transdermal permeation preparation. The high-efficiency transdermal permeation preparation comprises the following components: isosorbide dimethyl ether, inositol, tetrahydropiperine, an Odorsi seaweed extract, a rhodiola rosea root extract, an aloe extract, deionized water and the like. More effective components are obtained by self-preparing the Odorsi seaweed extract, the Rhodiola rosea root extract and the aloe extract; all the components are combined to form a mixture with high fat solubility, the efficient transdermal permeation effect is achieved, and the prepared transdermal permeation preparation is free of irritation to skin and does not cause inflammation.

The invention provides a mask containing silk fibroin composite microspheres and a preparation method of the mask. The mask takes silk fibroin composite microspheres, a centella asiatica extract, a yeast / zinc fermentation product and silk amino acids as skin protective agents. The fibroin composite microspheres can penetrate cell membranes and enter cells to achieve a transdermal absorption effect, open transdermal absorption channels for other active ingredients, greatly improve the transdermal permeation efficiency of the active ingredients, and ensure that the active ingredients can sufficiently and deeply reach a target action layer instead of only staying on the surface. The obtained mask has multiple effects of relieving, moisturizing, tightening and the like, solves the problems of existing market products in the aspects of efficacy synergy, penetration technology and the like, and has a wide application prospect.

This invention discloses a phenolic acid nano-alcoholic vesicle, its preparation method, and its application. This phenolic acid nano-alcoholic vesicle comprises biocompatible lipids, nonionic surfactants, medium-chain diols, transdermal absorption enhancers, phenolic acid, and water. Based on biocompatible lipids as the vesicle wall material, this invention employs nonionic surfactants as stabilizers to improve the stability, encapsulation efficiency, and penetration enhancement of the vesicles. The use of medium-chain diols facilitates the dissolution of phenolic acid, the formation of uniform vesicle vesicles, improves vesicle stability, and promotes transdermal absorption. The use of transdermal absorption enhancers regulates the surface properties of the vesicles, significantly enhancing the transdermal permeation, skin retention, and bioavailability of the active ingredients encapsulated in the vesicles, thereby greatly reducing the amount of active ingredients used and the raw material cost of cosmetics.

The invention discloses an SOD (superoxide dismutase) compound preparation and a preparation process thereof, and relates to the technical field of biochemical engineering. The preparation is composed of an SOD-trehalose eutectic nucleus, a lecithin / cholesterol bilayer and a hyaluronic acid targeting shell. The composition comprises the following components in percentage by mass: 0.5 to 1.2 percent of SOD (superoxide dismutase), 8 to 12 percent of trehalose, 4.5 to 6.0 percent of lecithin / cholesterol and 0.8 to 1.5 percent of hyaluronic acid. The preparation process comprises the following steps: 1) micro-fluidic low-temperature eutectic: emulsifying SOD and trehalose at 4 + / -1 DEG C through a micro-fluidic chip, and freezing at-30 + / -2 DEG C to form eutectic particles of 2.5 + / -0.3 mu m; 2) supercritical in-situ embedding: the particles react with lecithin / cholesterol for 40 + / -5 min in supercritical CO at 8 + / -0.5 MPa / 15 + / -2 DEG C, and the encapsulation efficiency is greater than or equal to 87%; and 3) cold spray drying: adding hyaluronic acid for homogenizing, and drying under the conditions that the air inlet temperature is less than or equal to 35 DEG C and the atomization pressure is 0.15 + / -0.02 MPa. The process realizes that the SOD activity recovery rate is greater than or equal to 92%, the transdermal permeation amount is increased by 3.2 times, the storage half-life period at 4 DEG C is predicted to reach 18 months through an acceleration test, and the problems of large activity loss, low encapsulation efficiency and thermal damage in the traditional process are solved.

The present application relates to the technical field of medicine, and provides a valerian microemulsion temperature-sensitive gel, a preparation method and application thereof.The valerian microemulsion temperature-sensitive gel is composed of a drug valerian extract, an oil phase, a surfactant, a cosurfactant, poloxamer, carboxymethyl chitosan and water.The prepared valerian microemulsion temperature-sensitive gel is in a liquid state at normal temperature, and is converted from the liquid state to a gel state when contacting the skin or mucosa temperature, has almost no irritation to the skin, is safe to use, has a large transdermal permeation amount, a high transdermal permeation rate, a long retention time on the skin surface or mucosa, and has a good sustained-release effect.The preparation method is simple, low in cost, convenient and safe to use, and can effectively promote skin wound healing.The present application provides a new drug dosage form for treating skin wounds or mucosa administration.