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67 results about "Transdermal permeation" patented technology

Compositions and Methods for Localized Drug Delivery through Mammary Papillae

The invention provides compositions and methods for the prevention, diagnosis, or treatment of conditions affecting breast tissue. The compositions can include one or more therapeutic agents or diagnostic agents, and an effective carrier. The composition can be specifically adapted for transdermal permeation through the mammary papilla, areola, or a combination thereof, and into underlying breast tissue.
Owner:SOUTH DAKOTA STATE UNIVERSITY

Solifenacin transdermal preparation and method for enhancing transdermal permeation thereof

The transdermal permeable property of solifenacin or a salt thereof as a biologically active substance, is remarkably improved using a fatty acid ester, a terpene or the like as a selected transdermal permeable promoter. The difference in effect exceeded expectations by producing an enhancement in permeability that represents an increase of several hundredfold at most, and several tenfold for practical application, enabling the provision of extremely useful means for preventive and therapeutic agents for urologic diseases or respiratory diseases that use solifenacin.
Owner:ASTELLAS PHARMA INC

Transdermal administered gel ointment containing rhizoma ligustici wallichii and nutgrass galingale rhizome

The invention provides gel ointment which is prepared from extract containing rhizoma ligustici wallichii and nutgrass galingale rhizome as an active ingredient and proper pharmaceutical necessities. The gel ointment is composed of a back lining layer, medicine-containing ointment and a release layer, wherein the medicine-containing ointment is prepared from extract of rhizoma ligustici wallichii and nutgrass galingale rhizome or refined product thereof, a thickening agent, a filling agent, a transdermal permeation accelerator, a humectant and other pharmaceutical necessities according to a certain ratio. The gel ointment can be transdermally administered, and is used for treating and alleviating migraine, gynecological pains and other syndromes.
Owner:SHENYANG PHARMA UNIVERSITY

Ropivacaine nanometer lipid carrier temperature-sensitive in-situ gel and preparation method thereof

The invention belongs to the technical field of medicinal preparations and specifically to a ropivacaine nanometer lipid carrier temperature-sensitive in-situ gel and a preparation method thereof. The ropivacaine nanometer lipid carrier temperature-sensitive in-situ gel disclosed by the invention mainly comprises bulk drug ropivacaine, a solid lipid material, a liquid lipid material, a surfactant, a cosurfactant, a gel matrix and injection water. The preparation method is a high-temperature emulsification low-temperature setting and cold melt method. The ropivacaine nanometer lipid carrier temperature-sensitive in-situ gel prepared in the invention is applied through transdermal drug delivery and has the advantages of a slow release function, a high transdermal permeation rate, a high entrapment rate, high drug loading capacity, good biocompatibility and good stability.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Compositions and methods for localized drug delivery through mammary papillae

The invention provides compositions and methods for the prevention, diagnosis, or treatment of conditions affecting breast tissue. The compositions can include one or more therapeutic agents or diagnostic agents, and an effective carrier. The composition can be specifically adapted for transdermal permeation through the mammary papilla, areola, or a combination thereof, and into underlying breast tissue.
Owner:SOUTH DAKOTA STATE UNIVERSITY

Acne removing and oil controlling microemulsion gel as well as preparation method and application thereof

The invention discloses an acne removing and oil controlling microemulsion gel and a preparation method thereof. The microemulsion gel is prepared from the following raw materials: 0.1-2 parts of salicylic acid, 0.1-3 parts of nicotinamide, 0.1-3 parts of ascorbic acid, 0.01-0.1 part of bisabolol, 0.01-0.2 part of zinc pyrrolidonecarboxylate, 0.01-0.5 parts of panthenol, 0.01-0.2 part of dipotassium glycyrrhizinate, 1-20 parts of an oil phase, 1-15 parts of a surfactant, 1-10 parts of a co-surfactant, 0.1-10 parts of a gel matrix material, 0.1-5 parts of a pH regulator, 0.1-1 part of a preservative and deionized water. The microemulsion gel provided by the invention is administered to skin, can increase a transdermal permeation rate, promotes transdermal absorption of multiple active ingredients, can achieve purposes of sustained release and long acting, has high product stability and good acne removing effect, and is simple in preparation process and suitable for industrial mass production.
Owner:连云港本草美汇医药科技有限公司

Acupoint paste for treating exogenous disease of infant

The invention relates to an acupoint paste for treating an exogenous disease of an infant, and can be used for effectively solving the problem of an externally-applied medicine for treating a common cold of the infant. According to the technical scheme, the acupoint paste is prepared from the following raw materials in parts by weight: 9g to 11g of semen brassicae, 4g to 6g of asarum sieboldii, 9g to 11g of rhizoma corydalis, 4g to 6g of euphorbia kansui, 1.5g to 3.5g of cortex cinnamomi, 14g to 16g of fresh ginger and 0.2g to 0.4g of azone. A preparation method comprises the following steps: grinding the semen brassicae, the asarum sieboldii, the rhizoma corydalis, the euphorbia kansui and the cortex cinnamomi to form fine powder; leading the fine powder to pass a sieve of 110 to 130 meshes; evenly mixing so as to obtain medicine powder; squeezing the fresh ginger into a juice; adding the juice into the medicine powder; adding the azone taken as a transdermal permeation agent; evenly mixing so as to obtain a medicine cream; coating the medicine cream on a backing material; cutting into a slice; and shielding a protective film on the slice, thereby obtaining the acupoint paste. The acupoint paste is abundant in raw materials, simple in method, easy to produce, convenient to use and good in effect, and can be effectively used for treating the common cold of the infant, thereby being a novel medicine for treating the common cold of the infant.
Owner:HENAN UNIV OF CHINESE MEDICINE

Transdermal peptide and application thereof

The invention provides polypeptide with a transdermal function or a transdermal enhanced function and a nucleotide sequence for encoding the polypeptide. The polypeptide can promote and / or enhance transdermal permeation of other substances, and the substances include micromolecular active substances and macromolecular active substances such as protein and nucleic acid. The invention further provides compositions containing the transdermal peptide, wherein the compositions include a beautifying agent, a hairdressing agent, a drug composition and the like.
Owner:深圳市百吉因生物科技有限公司

Patch for transdermal administration

A patch for transdermal administration having a sufficiently high transdermal permeation property of a COX-2 inhibitor to exert a superior antiinflammatory effect, the patch for transdermal administration comprising a backing and an adhesive layer which is placed on at least one side of the backing and comprises an adhesive base agent and a drug, wherein the drug is valdecoxib or a pharmaceutically acceptable salt thereof.
Owner:HISAMITSU PHARM CO INC

Rutin nanocrystal, rutin nanocrystal transdermal drug delivery gel and preparation method thereof

The invention discloses a rutin nanocrystal, rutin nanocrystal transdermal drug delivery gel and a preparation method thereof. The rutin nanocrystal contains a drug rutin and a stabilizer in the massratio being (1:0.06)-(1:3). The rutin nanocrystal transdermal drug delivery gel is prepared from 0.01%-5% of the rutin nanocrystal, 0.1%-5% of substrate gel, 1%-30% of a moisturizer and the balance ofwater. The rutin nanocrystal has the advantages of uniform particle size distribution, good stability, high saturation solubility, high dissolution rate and the like, the transdermal drug delivery gel is applied to transdermal drug delivery, can effectively overcome keratoderma barrier and notably improve the in-vitro transdermal permeation performance and the bioavailability of rutin, a preparation has a good treatment effect, besides, and damage to the keratoderma structure to a certain extent due to a physical means such as a common microneedle and the like for overcoming the keratoderma barrier is avoided.
Owner:CHINA PHARM UNIV

Adhesive skin patch containing serotonin receptor antagonist drug

ActiveUS9205060B2Efficient transdermal absorptionMaximum transdermal permeation rateOrganic active ingredientsDigestive systemNK1 receptor antagonistBULK ACTIVE INGREDIENT
Provided is a transdermal absorption-type patch containing a serotonin receptor antagonist, which has a short transdermal absorption delay time (lag time), and in which the maximum transdermal permeation rate of the drug can be reached within a short time and the drug can disappear from circulating blood rapidly. That is, provided is a patch containing a serotonin receptor antagonist, wherein the patch contains an adhesive layer comprising a non-functional acrylic adhesive, a water-soluble organic amine, a fatty acid ester, and a serotonin receptor antagonist such as granisetron as an active ingredient.
Owner:TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD

Enzyme silicone-oil-free shampoo

InactiveCN108042389AImprove hydration effectLong-lasting ability to maintain the water magnetic fieldCosmetic preparationsHair cosmeticsBiologyYeast extract
The invention discloses an enzyme silicone-oil-free shampoo. The shampoo is prepared from yeast beta-glucan and sodium carboxymethyl beta-glucan; the sum of weight percentages of yeast beta-glucan andsodium carboxymethyl beta-glucan in the shampoo is 0.2-2%. In the formula of the enzyme silicone-oil-free shampoo, the immunomodulatory activity of two yeast extracts, namely yeast beta-glucan and sodium carboxymethyl beta-glucan, is utilized to promote head skin growth, repair and protection, improve hair follicle activity, reduce hair loss and prolong the life cycle of hair, and the shampoo hasan obvious promoting effect on cell proliferation and also has a transdermal permeation effect and an anti-allergy and anti-inflammatory effect.
Owner:广州市博贤化妆品有限公司

Transdermal drug delivery preparation with drug-loaded three-dimensional mesh spatial configuration and preparation method of transdermal drug delivery preparation

The invention discloses a transdermal drug delivery preparation with a drug-loaded three-dimensional mesh spatial configuration and a preparation method of the transdermal drug delivery preparation. The transdermal drug delivery preparation with the drug-loaded three-dimensional mesh spatial configuration is composed of a transdermal drug delivery with the drug-loaded three-dimensional mesh spatial configuration, a backing layer and an anti-sticking layer, wherein the backing layer is compounded on one side of the transdermal drug delivery with the drug-loaded three-dimensional mesh spatial configuration; the anti-sticking layer is compounded on the other side of the transdermal drug delivery with the drug-loaded three-dimensional mesh spatial configuration; and an active medicine comprises the forms of oxybutynin hydrochloride or tartrate thereof, sulfate, phosphate, fumarate and a basic group. According to the transdermal drug delivery preparation, the drug loading capacity is greatly increased; the drug loading capacity can be improved; the medicine devitrification is inhibited; the medicines are sequentially and uniformly dispersed into the transdermal drug delivery system; stable release is carried out; long-term lasting transdermal permeation of the medicines can be realized; stable blood concentration is maintained; and the preparation is high in transdermal absorption rate and high in transdermal absorption amount, and has the characteristics of being stable and efficient.
Owner:SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT

Adhesive skin patch containing serotonin receptor antagonist drug

ActiveUS20140179734A1Efficient transdermal absorptionReduce latencyBiocideDigestive systemBULK ACTIVE INGREDIENTSkin patch
Provided is a transdermal absorption-type patch containing a serotonin receptor antagonist, which has a short transdermal absorption delay time (lag time), and in which the maximum transdermal permeation rate of the drug can be reached within a short time and the drug can disappear from circulating blood rapidly. That is, provided is a patch containing a serotonin receptor antagonist, wherein the patch contains an adhesive layer comprising a non-functional acrylic adhesive, a water-soluble organic amine, a fatty acid ester, and a serotonin receptor antagonist such as granisetron as an active ingredient.
Owner:TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD

Biological compounding method of vegetable cell activating factor and daily chemical product matrix raw material prepared from vegetable cell activating factor

The invention discloses a biological compounding method of a vegetable cell activating factor (or a method for preparing a daily chemical product matrix raw material containing the vegetable cell activating factor). The biological compounding method comprises the following steps: mixing a vegetable cell activating factor, a plant acid, a water phase and an oil phase, and carrying out electropolymerization (20-40 kHz) stirring for 20-60 min. The vegetable cell activating factor is selected from at least one of bioactive base, resveratrol, flavone, and polyphenol. According to the invention, thecharacteristic of high alkaloid content in the vegetable cell activating factor (VCAF) is utilized, and the VCAF is mixed with the plant acid to generate ionic liquid. In addition, the introduction of hydrophobic groups enables the ionic liquid to interact with hydrophobic molecules (oil phases), and the two complement each other, so that the VCAF is compounded with other components, serves as analkaloid role of the ionic liquid and also serves as a functional effective component. The method avoids the use of chemical emulsifiers and facilitates transdermal permeation.
Owner:广东绿色硅谷科技发展有限公司

Batrachotoxin Analogues, Compositions, Uses, and Preparation Thereof

InactiveUS20140171410A1Reduces and eliminates wrinkleReduced activityBiocideOrganic active ingredientsDiseaseBatrachotoxin
Compounds relating to batrachotoxin are provided, in particular analogues that modulate the activity of sodium channels. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier, including vehicles that modulate transdermal permeation of the compound. The subject compounds are useful in treatments, including treatments to reduce neuronal activity or to bring about muscular relaxation. The compounds also find use in the treatment of subjects suffering from a voltage-gated sodium channel-enhanced ailment or from pain. Further methods are provided for the preparation of the batrachotoxin-related compounds.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

Application of essential oil of alpinia oxyphylla miq. as penetration enhancer in fields of drug transdermal delivery and cosmetics

According to the invention, essential oil of alpinia oxyphylla miq. is taken as a major research object, and the effect of the essential oil on promoting drug transdermal permeation is investigated. On the basis of systematic investigation, both fruit essential oil and leaf essential oil of the alpinia oxyphylla miq. are relatively strong in penetration enhancing effect; and when the concentration of the essential oil is 3%, the penetration enhancing effect of the fruit essential oil and the leaf essential oil on drugs is obviously better than that of a common skin penetration enhancer, namely azone. Based upon GC-MS analysis, as for major ingredients, the fruit essential oil and the leaf essential oil are different in contents of alkane terpene and oxy-terpene ingredients; therefore, the fruit essential oil and the leaf essential oil keep a certain difference in drug penetration enhancing effect. In addition, the result of a skin irritation test proves that the fruit essential oil and the leaf essential oil, at an appropriate concentration, can avoid any erythema or edema in animal skin. Therefore, the essential oil of the alpinia oxyphylla miq., with the significant penetration enhancing effect and safety to the skin, has a broad development and application prospect in the fields of drug delivery and cosmetics.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI HAINAN BRANCH +1

Pramipexole nanocrystal transdermal gel and preparation method thereof

The invention relates to pramipexole nanocrystal transdermal gel and a preparation method thereof, belonging to the technical field of medicines. Pramipexole nanocrystals with uniform appearances are prepared by virtue of a medium grinding method, and the average particle size of the pramipexole nanocrystals is 200nm-400nm. The transdermal gel is prepared from the pramipexole nanocrystals, so that the transdermal permeation rate of pramipexole is remarkably increased, and pramipexole can permeate into a human body within 3 days at a constant speed. The pramipexole nanocrystal transdermal gel has moderate viscosity, low skin stimulation and good stability and is capable of remarkably improving the medication compliance of patients with Parkinson disease. Meanwhile, the pramipexole nanocrystal transdermal gel further has the advantages that a preparation process is simple, the quality is safe and stable, industrial production is easily realized, and the like.
Owner:CHINA PHARM UNIV

Preparation method and application of galvanic-response transdermal drug delivery system

The invention relates to a preparation method and application of galvanic-response gel for drugs loaded on carbon nanotubes functionalized with carboxylic groups. The technical scheme includes that the preparation method includes (1) dissolving the drugs by proper solvents and preparing a load by adding the dissolved drugs into the carbon nanotubes functionalized with carboxylic groups prior to refrigeration and ball milling; (2) using the carbon nanotubes, polyacrylic acid, polyvinyl alcohol and the like for forming a gel matrix and adding the load so as to obtain the gel; (3) using the gel for transdermal drug delivery under the action of an external electric field. The preparation method is simple in preparation process, mild in experiment conditions and easy to operate; the poorly water-soluble drugs are loaded on the carbon nanotubes functionalized with carboxylic groups, so that water solubility of the drugs is enhanced; release of the drugs is related to the external electric field, drug transdermal permeation rate can be increased effectively, and accordingly high practical value is achieved.
Owner:SOUTH CHINA AGRI UNIV

Composition for treating acne and preparation method of composition

The invention discloses a composition for treating acne and a preparation method of the composition. The composition comprises cryptotanshinone, tea polyphenol, choline hydroxide and salicylic acid. Various test results prove that the composition can be used for effectively treating the acne caused by various pathogenesis, the treatment effect is superior to that of a single-component medicine, and an obvious synergistic effect is shown; and meanwhile, the problems of poor water solubility, poor transdermal permeation, poor absorption and the like of the cryptotanshinone are solved, and the medicine concentration in an organism is improved.
Owner:SUN YAT SEN UNIV

Water-based polyurethane functional facial mask matrix and application thereof

The invention discloses a water-based polyurethane functional facial mask matrix and an application thereof. The facial mask matrix is prepared by taking two water-based polyurethane dispersions as main components. Through a special cross-linking structure of a polyurethane film, transdermal permeation absorption of components with functions such as whitening, moisturizing, anti-aging and the likein the facial mask product is promoted. When the facial mask matrix is used, a facial mask uniformly coats on a face, and after the facial mask is dried, the whole piece of the facial mask can be directly taken down or can be taken down after being wetted by water. The mask matrix provided by the invention is also suitable for body films such as hand films, neck films, back films, and the like.
Owner:WANHUA CHEM GRP CO LTD +1

Moisturizing and antioxidant dendrobium officinale-containing skin-care lotion and preparation method thereof

The invention discloses a moisturizing and antioxidant dendrobium officinale-containing skin-care lotion. The moisturizing and antioxidant dendrobium officinale-containing skin-care lotion consists of a component A and a component B, wherein dendrobium officinale ethosome in the component B has good superdeformation, and under the hydration pressure of skin, the ethosome can carry contents to run through small pores which are 1 / 5-1 / 10 smaller than itself, can quickly enter the deep skin and is an effective transmission carrier facilitating permeation of active components of a dendrobium officinale extract into the skin, so that the problem that the conventional skin-care products commonly have poor permeation is solved, and the transdermal permeation effect of the active components of the dendrobium candidum is improved; the dendrobium officinale-containing skin-care lotion is high in accumulation amount of the active components, simple in preparation process, safe in raw materials and non-irritant to the skin, has the efficacies of significantly maintaining or restoring skin elasticity, reducing or repairing fine lines of the skin, inhibiting deposition of lipofuscin, resisting ultraviolet radiation and slowing skin aging, and can effectively inhibit formation of skin light aging and sunshine sunburn caused by ultraviolet irradiation.
Owner:宁波易中禾生物技术有限公司

Piezoelectric electret drug delivery patch for transdermal drug delivery in combination with pressing or flapping as well as preparation method and application of same

The invention provides a piezoelectric electret drug delivery patch for transdermal drug delivery in combination with pressing or flapping as well as a preparation method and application of the same. The piezoelectric electret drug delivery patch comprises a covering layer, a piezoelectric electret layer and a drug layer which are sequentially arranged in a stacked mode. And the piezoelectric electret layer comprises a piezoelectric electret and a metal electrode combined with the piezoelectric electret. The piezoelectric electret drug delivery patch generates micro-current pulses through touching or beating, the fluidity of skin lipoid is improved, drug molecules enter a channel penetrating through the skin cuticle and expand, and then the transdermal permeation efficiency of the drug is obviously improved.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI

Meloxicam patch as well as preparation method and application thereof

The invention provides a meloxicam patch as well as a preparation method and application thereof. The meloxicam patch comprises a back lining layer, a medicine storage layer and an anti-sticking layer, wherein medicine storage layer is prepared from an active component-meloxicam or pharmaceutically acceptable salts thereof, pressure-sensitive adhesive and a drug transdermal absorption accelerant, wherein the dosages of the meloxicam or the pharmaceutically acceptable salts thereof and the drug transdermal absorption accelerant respectively account for 0.5-60% and 0.1-50% of the solid component weight content of the medicine storage layer. The preparation method of the meloxicam patch comprises the steps of dissolving the meloxicam or the pharmaceutically acceptable salts thereof into a solvent, sequentially adding all pharmaceutic accessories into the obtained solution, stirring and evenly mixing; standing and degassing, coating, volatilizing the solvent, compounding the back lining layer, and cutting the product into a patch with suitable size according to the dosage requirement. The meloxicam patch is high in adhesiveness and good in flexibility, not only can avoid stimulation, caused by orally taking a medicine, for the gastrointestinal tract, but also can improve the transdermal permeation of the medicine, is lasting and stable in curative effect, and can be interrupted at any time.
Owner:SHENYANG PHARMA UNIVERSITY +1

Multifunctional eye drug guiding instrument

PendingCN109303975APromotes transdermal penetrationRelieve eye fatigue, prevent myopia and other problemsDevices for pressing relfex pointsMedical devicesMassageTransdermal permeation
The invention relates to an eye healthcare product, in particular to a multifunctional eye drug guiding instrument. The multifunctional eye drug guiding instrument comprises a supporting framework anda massage part fixed to the supporting framework. The multifunctional eye drug guiding instrument is characterized in that the eye area of the guiding instrument is provided with a water absorbing material used for absorbing liquid drugs used for treating shortsightedness, and the water absorbing material is in direct contact with the eye skin; the massage part is provided with several massage pillars which are used for stimulating acupoints around the eyes to make the eye skin fully absorb the liquid drugs, and the guiding instrument is further provided with a micro current massage assemblyused for promoting transdermal permeation of the liquid drugs. By putting the material absorbing sufficient liquid drugs or healthcare drug liquid for treating shortsightedness into the correspondingpositions of the eyeballs, the massage pillars can press the acupoints around the eyes, the micro current assembly stimulates the acupoints, at the same time, transdermal permeation of the drugs is promoted, the eyes of the human body are treated, and the effects of effectively relieving eyestrain and preventing and treating shortsightedness are achieved.
Owner:GUANGZHOU FOUNDERY IND CO

Percutaneous penetration-promoting drug delivery device

The invention discloses a percutaneous penetration-promoting drug delivery device which comprises a microneedle base, a plurality of microneedles are fixedly arranged on the front face of the microneedle base, an injector and piezoelectric ceramics are fixedly arranged on the back face of the microneedle base, an injection channel communicated with the microneedles and the injector is formed in the microneedle base, and the piezoelectric ceramics are used for driving the microneedles to conduct high-frequency vibration.According to the transdermal permeation-promoting drug delivery device, two permeation-promoting mechanisms of the microneedle and the acoustophoresis are combined, a physical channel from a cuticle layer to a corium layer is continuously provided while a drug is injected, permeation of macromolecular drugs is promoted, high-frequency vibration is generated under external excitation by utilizing the inverse piezoelectric effect of piezoelectric ceramics, ultrasonic waves are emitted. The diffusion speed of the medicine in the skin is effectively increased, and tissue deformation is reduced when the medicine is punctured.
Owner:CENT SOUTH UNIV

Chinese medicine permeation promoting material, transdermal medicine with the material and its prepn process

The present invention adopts volatile oil of plant, such as ginger, orange peel and clove as the material for promoting transdermal permeation of medicine, including magnolia bark medicine membrane as the exhaustion promoter to promote post-operation gastrointestinal peristalsis and red sage medicine membrane for local promoting blood circulation to disperse blood clots to treat scapulohumeral periarthritis and femoral head necrosis. The material for promoting transdermal permeation of medicine of the present invention has higher transdermal permeation promoting effect and less irritation to skin compared with available material.
Owner:杨小林

New biodegradable penetration enhancers with multiple hydrophilic moieties

Design of new, safe and effective biodegradable agents, which can cover a wide range of drug molecules in the transdermal permeation and other membranes absorption of physiologically active agents are disclosed. Biodegradable agents includes compounds having a multiple hydrophilic moiety groups which are water loving groups with general chemical structures provide for contributing the penetration enhancement characteristics such as glycolic group and N-alkyl substituted amino acidic group and a lipophilic moiety and also in contributing the balanced lipophilicity of the compounds such as long chain alkyl group are disclosed. More particularly, compounds with R1, and R2, as the steric hindered but can significantly affect the hydrolytic and enzymatic degradation or stability of the biodegradable enhancers. With these physical chemical features, the disclosed compound can influence the efficacy, toxicity, irritation, duration of action of the enhancers, and the reversibility of the skin, and the stability of the enhancers. The substituents also affect the final lipophilicity of the enhancers as the compounds will have higher partition coefficient values.
Owner:WONG OOI

Nano resveratrol-coated compound as well as preparation method and application thereof

The invention belongs to the field of a nanotechnology, and provides a nano resveratrol-coated compound as well as a preparation method and application thereof. The preparation method of the nano resveratrol-coated compound comprises the following steps of (1) mixing a lecithin solution and a resveratrol solution to obtain a first mixed solution; (2) adding the first mixed solution into water to obtain a second mixed solution; and (3) purifying the second mixed solution to obtain the nano resveratrol-coated compound. After resveratrol coats lecithin nanoparticles, the effect of continuously and slowly releasing antioxidant components and the good effect of promoting transdermal permeation of antioxidants are achieved, the residence time of the resveratrol in the acting skin part is prolonged, and the bioavailability of the resveratrol is improved.
Owner:JIANGXI SCI & TECH NORMAL UNIV +1
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