The invention discloses an acne removing and oil controlling microemulsion gel and a preparation method thereof. The microemulsion gel is prepared from the following raw materials: 0.1-2 parts of salicylic acid, 0.1-3 parts of nicotinamide, 0.1-3 parts of ascorbic acid, 0.01-0.1 part of bisabolol, 0.01-0.2 part of zinc pyrrolidonecarboxylate, 0.01-0.5 parts of panthenol, 0.01-0.2 part of dipotassium glycyrrhizinate, 1-20 parts of an oil phase, 1-15 parts of a surfactant, 1-10 parts of a co-surfactant, 0.1-10 parts of a gel matrix material, 0.1-5 parts of a pH regulator, 0.1-1 part of a preservative and deionized water. The microemulsion gel provided by the invention is administered to skin, can increase a transdermal permeation rate, promotes transdermal absorption of multiple active ingredients, can achieve purposes of sustained release and long acting, has high product stability and good acne removing effect, and is simple in preparation process and suitable for industrial mass production.