30 results about "Transdermal permeation" patented technology

The invention discloses a colchicine external preparation with high intradermal residual quantity and percutaneous transmittance as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The invention provides a colchicine external preparation with high intradermal residue and transdermal transmittance. The colchicine external preparation comprises: a) colchicine or a pharmaceutically acceptable salt thereof; b) a penetration enhancer; c) pharmaceutically acceptable excipients and / or excipients; the penetration enhancer is at least one of polyglycerol oleate or isosorbide dimethyl ether. The drug loading capacity and the percutaneous transmittance of the colchicine external preparation disclosed by the invention are remarkably improved. When polyglycerol oleate is selected as a penetration enhancer to prepare colchicine gel, the intradermal retention volume can reach 358.08 micrograms within 20 hours. When isosorbide monomethyl ether is selected as a penetration enhancer to prepare ethosome gel, the accumulated penetration amount can reach 106.87 mu g / cm < 2 >, and the intradermal residual amount can reach 90.58 mu g or above.

The invention discloses a drug-loaded protein-phospholipid composite nanoparticle as well as a preparation method and application thereof. The drug-loaded protein-phospholipid composite nanoparticle has a core-shell structure, an inner core comprises silk fibroin and a hydrophilic drug, a shell layer comprises a plurality of phospholipid bimolecular layers which are stacked layer by layer, each phospholipid bimolecular layer comprises soya bean lecithin, a hydrophobic drug is embedded in a hydrophobic region in each phospholipid bimolecular layer, and the hydrophobic drug is embedded in a hydrophobic region in each phospholipid bimolecular layer. Silk fibroin and a hydrophilic drug are embedded in the hydrophilic area, and zein and cholesterol are embedded in the phospholipid bilayer. The drug-loaded protein-phospholipid composite nanoparticle can simultaneously embed a hydrophobic drug and a hydrophilic drug, has the advantages of large drug loading capacity, high bioavailability, good stability, good transdermal permeation effect and the like, has wide application prospects in the fields of transdermal drug delivery preparations and skin care products, and is simple in preparation method, mild in reaction condition and suitable for industrial production. The method is suitable for large-scale industrial production and application.

The invention relates to the technical field of traditional Chinese medicine, in particular to traditional Chinese medicine meridian dredging massage cream and a preparation method thereof, myrrh (a monarch drug), kudzuvine root (a ministerial drug) and notopterygium root (an adjuvant drug) are used as core components, menthol, vanillyl butyl ether and other transdermal permeation enhancing systems are used as auxiliary materials, and an oil-in-water type microemulsion matrix is constructed. Through six innovations of'monarch-minister-assistant 'meridian targeted compatibility, three-dimensional transdermal permeation promotion and multi-component synergistic anti-inflammation, the effects of relaxing tendons, activating collaterals, dispelling wind and dissipating blood stasis are achieved. The preparation process adopts ultrasonic extraction and high-pressure homogenization technologies, and the integrity of active ingredients is reserved. The product is suitable for scenes such as cervical spondylosis, scapulohumeral periarthritis and rheumatic ostealgia and has the advantages of high transdermal efficiency, long-acting analgesia, good safety and the like, experimental verification shows that the transdermal amount within 24 hours is increased by 130%, the inflammatory factor inhibition rate reaches 89.2%, and the clinical effective rate is remarkably superior to that of commercially available products.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine essential oil microencapsulation transdermal absorption process. The core of the process is that a transdermal enhancer, traditional Chinese medicine essential oil and a wall material are synchronously added in an emulsification stage, a uniform emulsion system is formed through emulsification treatment, then curing treatment is performed to enable the wall material to be crosslinked to form microcapsules, and the microcapsules are separated, dried and dispersed in a matrix to prepare the transdermal preparation. According to the method, full integration of a transdermal enhancer and a microcapsule structure is realized, transdermal permeation of essential oil components is effectively promoted, meanwhile, the stability and biological activity of the essential oil are kept, and the clinical application value of the traditional Chinese medicine essential oil is improved.

This invention provides tranexamic acid liposomes, their preparation method, and applications, relating to the field of nanoliposome technology. This invention utilizes a simple process to prepare tranexamic acid liposomes by rationally combining the ratios of tranexamic acid, phospholipids, and cholesterol. This invention achieves high loading capacity and high loading rate for the active ingredient tranexamic acid, maintaining its stability for a long time under various temperature conditions. The tranexamic acid liposomes prepared by this invention have a particle size between 10-50 nm, enabling better penetration into the stratum corneum and targeting the basal layer of the skin, providing a long-lasting and stable effect. Compared to liposomes prepared by other processes, they exhibit excellent transdermal permeability and skin retention, which is more conducive to the efficacy of the active ingredient, significantly improving its bioavailability and resulting in a greater skin-lightening effect.

The application discloses a quick and efficient melatonin transdermal delivery system, which is characterized by comprising the following structures arranged from top to bottom: at least one protective layer; at least one polymer base layer; and a multilayer structure of an anti-adhesion layer; wherein the polymer base layer comprises the following components by weight: compared with the prior art, the system has the following beneficial effects: compared with oral use of melatonin, the melatonin efficient delivery system reduces the dosage of melatonin by 50% to 400% and reduces side effects, and can improve the transdermal penetration rate of melatonin within the first two hours.

The present application relates to a kind of foam type cationic nanoemulsion hair lotion and its preparation method, belong to hair lotion technical field.The preparation method of the present application includes the following steps, S1, surfactant, oil phase material, co-surfactant and bacteriostatic agent are mixed uniformly, drug is added, heating is made to be fully dissolved, and oil phase is obtained;S2, oil phase is added dropwise into aqueous phase, essence is added, and the foam type cationic nanoemulsion hair lotion is obtained;The aqueous phase includes chitosan derivative and water.Utilize the positive electricity of chitosan derivative, make the charge of nanometer emulsion of surface negative charge reverse, make it and epidermal cell better interaction, reduce the amount of drug penetration, improve the amount of drug in skin retention, while chitosan derivative has strong permeability and adhesion, synergistic with foam agent improves the amount of drug in skin retention, prolongs the retention time of drug in vivo, increases the time of drug penetration effect, better play local effect.

According to the preparation method of the chlorogenic acid-methotrexate soluble microneedle, chondroitin sulfate and a methyl vinyl ether-maleic anhydride copolymer are adopted as matrix materials, and the drug-loaded microneedle is prepared through a two-step centrifugation method. The length of a needle body of the prepared microneedle is about 500 microns, the microneedle has good mechanical strength and skin puncture performance, the microneedle can be basically dissolved within 2 hours, the average drug content of chlorogenic acid is 57.97 + / -1.76 mu g / tablet, and the average drug content of methotrexate is 56.32 + / -1.67 mu g / tablet. An in-vitro percutaneous penetration test shows that the 6-hour cumulative transdermal rate of chlorogenic acid reaches 93.96%, the 6-hour cumulative transdermal rate of methotrexate reaches 86.92%, which are respectively 22.1 times and 3.0 times that of a control solution group, so that the efficient percutaneous delivery of the medicine is realized. The microneedle is small in skin irritation, the skin barrier can be naturally repaired within 15 minutes after puncture, and a new administration approach is provided for treatment of skin diseases such as psoriasis.

The invention relates to the technical field of cosmetics, in particular to a nano-coated alpha-arbutin deep eutectic and a preparation method and application thereof. The nano-coated alpha-arbutin deep eutectic is prepared from the following raw materials in parts by weight: 15 to 30 parts of soybean phospholipid, 4 to 10 parts of cholesterol, 1 to 5 parts of DSPE-PEG2000, 80 to 120 parts of choline chloride / alpha-arbutin DEA, 3 to 8 parts of trehalose and 3 to 8 parts of propylene glycol. Wherein choline chloride / alpha-arbutin DEA and alpha-arbutin form a stable deep eutectic through a hydrogen bond network by taking choline chloride as a hydrogen bond receptor, so that the problems of water solubility and photo-thermal instability of the deep eutectic are solved, and the transdermal permeation efficiency and the oxidation resistance are improved. Choline chloride / alpha-arbutin DEA is wrapped by nano-liposomes to form a physical barrier, so that external ultraviolet and high-temperature environments are avoided, the risk that the choline chloride / alpha-arbutin DEA is decomposed into hydroquinone is reduced, and the storage stability of active ingredients is prolonged.

The invention discloses a permeation-promoting and solubilizing meloxicam transdermal patch, and belongs to the field of pharmaceutics. The patch consists of a backing layer, a drug-loading pressure-sensitive adhesive layer and an anti-sticking layer, wherein the drug-loading pressure-sensitive adhesive layer consists of a solvent type pressure-sensitive adhesive, meloxicam, a penetration enhancer and a solubilizer. According to the patch, transdermal delivery of meloxicam is achieved, various penetration enhancers and solubilizers are systematically screened, so that meloxicam in the patch is continuously administered at a proper transdermal permeation rate, effective blood concentration can be maintained in a relatively prolonged time, the administration frequency is reduced, and the problem that the in-vitro accumulated permeation amount of the meloxicam patch is low is solved. The meloxicam patch has the characteristics of high percutaneous penetration amount and continuous administration, and is effectively used for skin administration treatment of osteoarthritis and rheumatoid arthritis.

The invention discloses an invisible flexible closed transdermal repair device, and belongs to the technical field of skin care devices. The device is formed by compounding an inner medicine contact layer, a middle flexible closed fitting layer and an outer simulation invisible shading layer, and can be applied to any skin part of the whole body of a human body. The inner layer is loaded with skin repairing active ingredients, so that continuous slow release and transdermal permeation of the medicine are realized; the middle layer is made of a flexible moldable material to form a closed microenvironment, so that water and medicine are locked, and the dry side effect of the medicine is counteracted; the outer layer has the full-shading performance and the skin simulation appearance, visual invisibility can be achieved, photosensitive component medicine can be protected to stably take effect in the daytime, and meanwhile cosmetic modification is supported. The device can automatically maintain skin micro-moisture balance, improves wearing comfort and long-term tolerance, is compatible with multi-scene hidden wearing such as daily make-up and social contact while efficiently repairing the skin, and is high in universality and wide in application prospect.

The invention discloses a double-drug-loading soluble microneedle patch with a hypertrophic scar improving function as well as a preparation method and application of the double-drug-loading soluble microneedle patch, and belongs to the technical field of medical cosmetology. The microneedle patch comprises a substrate and a needle body arranged on the surface of the substrate, wherein the needle body is mainly prepared from a cyclodextrin inclusion compound, colchicine and a microneedle framework material; the cyclodextrin inclusion compound is prepared from an insoluble drug shikonin and beta-cyclodextrin, and the microneedle framework material is prepared from sodium hyaluronate and polyvinylpyrrolidone. The double-drug-loading soluble microneedle patch has good mechanical strength and can accurately penetrate through scar skin to form a drug delivery channel. Compared with a traditional transdermal patch, the soluble microneedle has the advantages that the transdermal permeation efficiency of the medicine is greatly improved, and compared with traditional injection administration, the soluble microneedle reduces long-term irritation to the skin, reduces the risk of adverse reactions such as infection and bleeding and has a very good application prospect.

The application discloses a kind of total glycosides of Paeonia lactiflora and non-steroidal anti-inflammatory drug composition in transdermal drug preparation application.In transdermal drug preparation the application advantage of this composition is in:(1) the active epidermal barrier and stratum corneum barrier of skin is the main obstacle of total glycosides of Paeonia lactiflora transdermal absorption.The non-steroidal anti-inflammatory drug in the composition can reversibly open the active epidermal barrier of skin, if it is used with the skin stratum corneum barrier of penetration enhancer and can significantly improve the transdermal penetration performance of total glycosides of Paeonia lactiflora in this transdermal drug preparation, it is a kind of with simple preparation process, easy industrial production, skin non-invasive characteristics can safely, efficiently improve the method for the transdermal penetration ability of total glycosides of Paeonia lactiflora;(2) total glycosides of Paeonia lactiflora and non-steroidal anti-inflammatory drug combination in transdermal drug preparation, in the curative effect of treating primary dysmenorrhea and rheumatoid arthritis disease has obvious synergistic effect, curative effect is excellent.

The hydrogen percutaneous permeation device comprises a flat bag type gas diffuser, the bag type gas diffuser is communicated with one end of a gas guide pipe through a quick disassembly head, and the other end of the gas guide pipe is communicated with a pressure stabilizing gas supply unit; the pressure stabilizing air supply unit comprises an air cavity, the interior of the air cavity is divided into an air supply cavity and a pressure adjusting cavity through an extrusion diaphragm, an air outlet of the air supply cavity is communicated with the air guide pipe and used for conveying treatment air, and the pressure adjusting cavity is connected with the pressurizing mechanism which is used for pumping air into the pressure adjusting cavity. The extrusion diaphragm is pushed to deform so as to compress the volume of the air supply cavity; a pressure reduction unit is arranged on the gas guide tube and is used for controlling the pressure of the treatment gas conveyed to the bag type gas diffuser to be preset treatment pressure; the bag type gas diffuser is fixed to the periphery of the focus through the pressurization fixing assembly. The device does not need to be directly connected with a large external hydrogen source, and can provide a more efficient and convenient local treatment effect for a patient.

The invention belongs to the technical field of pharmaceutical preparations, and relates to an olbucaine hydrochloride composition and application thereof. The olbucaine hydrochloride composition is prepared from the following components in parts by weight: 10 to 65 parts of olbucaine hydrochloride, 10 to 42 parts of penetration enhancer, 5 to 20 parts of pH (Potential of Hydrogen) regulator and 900 to 1000 parts of water. The olbucaine hydrochloride composition can significantly improve the percutaneous penetration efficiency of the medicine, improve the efficacy of superficial anesthesia, prolong the ejaculation time, and achieve the effect of preventing and treating premature ejaculation.

A preparation and a use of a nucleic acid with anti-hair loss and oil control effects and a composition including the nucleic acid are provided. The small interfering RNA (siRNA) sequence has a significant silencing effect for the androgen receptor (AR) target gene. The composition prepared from an ionic liquid or a combination of an ionic liquid and a lipid exhibits a prominent delivery effect for water-soluble nucleic acid molecules. The composition can penetrate cells and enter cell nuclei to achieve an AR-silencing effect, and can provide significant regulatory effects for downstream target genes or proteins regulated by AR and comprehensive anti-hair loss and oil control effects. The composition exhibits a prominent transdermal permeation-promoting effect, and can permeate the epidermis layer and reach the dermis layer to exert remarkable anti-hair loss and oil control effects. In addition, the composition has a high antibacterial activity against Propionibacterium acnes.

The present invention discloses a non-steroidal anti-inflammatory drug transdermal patch, which comprises a backing layer, a plaster layer and a release liner. The raw materials of the plaster layer are: indomethacin, amphiphilic cholesterol derivatives, isopropyl myristate, menthol, modified polyacrylate adhesive solution, tackifier, crosslinking agent, main drug solvent, wherein the modified polyacrylate adhesive solution uses ethyl acetate as a reaction solvent, and polyethylene glycol and zinc-based zeolitic imidazolate framework materials are respectively introduced during the polymerization of isooctyl acrylate, methyl acrylate and dimethylaminoethyl methacrylate; the present invention also discloses a preparation process of the non-steroidal anti-inflammatory drug transdermal patch. The non-steroidal anti-inflammatory drug transdermal patch of the present invention has air permeability, moderate adhesion, no skin irritation, can be administered locally, has a high transdermal permeation amount and a low residual drug amount, helps to improve the bioavailability and efficacy of the drug, and reduces the number of drug administrations and the drug dosage.

The present invention relates to a pharmaceutical composition for preventing or treating cancer, and preparation method therefor, the composition comprising a complex of a transdermal permeation peptide and a saccharide, and a lectin. It has been identified that, when the composition comprising the complex of the transdermal permeation peptide and the saccharide, and the lectin is used for cancer treatment, skin permeation of anticancer substances is improved, anti-tumor activity and anti-metastasis properties are exhibited, and hepatotoxicity is not exhibited, and thus effective use as a composition for anticancer treatment is possible.

The invention provides a mask containing silk fibroin composite microspheres and a preparation method of the mask. The mask takes silk fibroin composite microspheres, a centella asiatica extract, a yeast / zinc fermentation product and silk amino acids as skin protective agents. The fibroin composite microspheres can penetrate cell membranes and enter cells to achieve a transdermal absorption effect, open transdermal absorption channels for other active ingredients, greatly improve the transdermal permeation efficiency of the active ingredients, and ensure that the active ingredients can sufficiently and deeply reach a target action layer instead of only staying on the surface. The obtained mask has multiple effects of relieving, moisturizing, tightening and the like, solves the problems of existing market products in the aspects of efficacy synergy, penetration technology and the like, and has a wide application prospect.

This invention discloses a phenolic acid nano-alcoholic vesicle, its preparation method, and its application. This phenolic acid nano-alcoholic vesicle comprises biocompatible lipids, nonionic surfactants, medium-chain diols, transdermal absorption enhancers, phenolic acid, and water. Based on biocompatible lipids as the vesicle wall material, this invention employs nonionic surfactants as stabilizers to improve the stability, encapsulation efficiency, and penetration enhancement of the vesicles. The use of medium-chain diols facilitates the dissolution of phenolic acid, the formation of uniform vesicle vesicles, improves vesicle stability, and promotes transdermal absorption. The use of transdermal absorption enhancers regulates the surface properties of the vesicles, significantly enhancing the transdermal permeation, skin retention, and bioavailability of the active ingredients encapsulated in the vesicles, thereby greatly reducing the amount of active ingredients used and the raw material cost of cosmetics.

The invention discloses an SOD (superoxide dismutase) compound preparation and a preparation process thereof, and relates to the technical field of biochemical engineering. The preparation is composed of an SOD-trehalose eutectic nucleus, a lecithin / cholesterol bilayer and a hyaluronic acid targeting shell. The composition comprises the following components in percentage by mass: 0.5 to 1.2 percent of SOD (superoxide dismutase), 8 to 12 percent of trehalose, 4.5 to 6.0 percent of lecithin / cholesterol and 0.8 to 1.5 percent of hyaluronic acid. The preparation process comprises the following steps: 1) micro-fluidic low-temperature eutectic: emulsifying SOD and trehalose at 4 + / -1 DEG C through a micro-fluidic chip, and freezing at-30 + / -2 DEG C to form eutectic particles of 2.5 + / -0.3 mu m; 2) supercritical in-situ embedding: the particles react with lecithin / cholesterol for 40 + / -5 min in supercritical CO at 8 + / -0.5 MPa / 15 + / -2 DEG C, and the encapsulation efficiency is greater than or equal to 87%; and 3) cold spray drying: adding hyaluronic acid for homogenizing, and drying under the conditions that the air inlet temperature is less than or equal to 35 DEG C and the atomization pressure is 0.15 + / -0.02 MPa. The process realizes that the SOD activity recovery rate is greater than or equal to 92%, the transdermal permeation amount is increased by 3.2 times, the storage half-life period at 4 DEG C is predicted to reach 18 months through an acceleration test, and the problems of large activity loss, low encapsulation efficiency and thermal damage in the traditional process are solved.

The present application relates to the technical field of medicine, and provides a valerian microemulsion temperature-sensitive gel, a preparation method and application thereof.The valerian microemulsion temperature-sensitive gel is composed of a drug valerian extract, an oil phase, a surfactant, a cosurfactant, poloxamer, carboxymethyl chitosan and water.The prepared valerian microemulsion temperature-sensitive gel is in a liquid state at normal temperature, and is converted from the liquid state to a gel state when contacting the skin or mucosa temperature, has almost no irritation to the skin, is safe to use, has a large transdermal permeation amount, a high transdermal permeation rate, a long retention time on the skin surface or mucosa, and has a good sustained-release effect.The preparation method is simple, low in cost, convenient and safe to use, and can effectively promote skin wound healing.The present application provides a new drug dosage form for treating skin wounds or mucosa administration.

The invention discloses a dexheptane structure prostacyclin-loaded nano transdermal patch and a preparation method, the dexheptane structure prostacyclin-loaded nano transdermal patch comprises 10-30 parts of dexheptane precursor liposome, 10-20 parts of a prostacyclin nano-structure lipid carrier and 50-70 parts of an acrylate pressure-sensitive adhesive, the dexheptane precursor liposome comprises 8-12 parts of dexheptane and 36-54 parts of hydrogenated soya bean lecithin, and the prostacyclin nano-structure lipid carrier comprises a prostacyclin nano-structure lipid carrier and an acrylate pressure-sensitive adhesive. The prostacyclin injection comprises the following components in parts by weight: 36-54 parts of mannitol, 80-240 parts of absolute ethyl alcohol, 150-450 parts of purified water, 0.150-0.200 part of prostacyclin, 80-150 parts of glyceryl monostearate, 20-50 parts of oleic acid, 10-30 parts of soybean lecithin and the balance of purified water, wherein the total amount of the prostacyclin injection, the glyceryl monostearate, the oleic acid, the soybean lecithin and the purified water is 1000 parts. According to the invention, the dextroheptane is used as a functional penetration enhancing component in transdermal drug delivery, the dextroheptane and the prostacyclin are synergistically integrated in the nano-lipid carrier, the transdermal penetration rate and the cumulative penetration amount of the prostacyclin are improved, the treatment effect is improved, and continuous and stable release of the prostacyclin is realized under the combined action of the nano-structure lipid carrier and the patch matrix.

The invention relates to an in-vitro permeability analysis method of lidocaine hydrochloride gel, which relates to the technical field of medicine, and comprises the following steps: placing a transdermal material with a gasket on a receiving pool of a transdermal instrument, taking a lidocaine hydrochloride gel test sample to be detected, smearing the gasket with the lidocaine hydrochloride gel test sample, and operating according to a method set by the transdermal instrument, receiving liquid in the receiving pool is taken at different time for detection; the transdermal material is a pig bladder mucous membrane, the thickness of the transdermal material is 0.25-0.80 mm, and the receiving medium is a PBS (Phosphate Buffer Solution) with the pH value of 7.4. The method can accurately evaluate the rate and the degree of the lidocaine hydrochloride gel reaching the skin action part or the vicinity, is beneficial to evaluation of the transdermal permeation behavior of the medicine, simulation of the transdermal process of the medicine under physiological conditions, control of the quality of the lidocaine hydrochloride gel, evaluation of the preparation performance and improvement of the safety of the product. The method can quickly evaluate the drug release and absorption characteristics, and is low in cost, short in period, green and environment-friendly.

The invention discloses a traditional Chinese medicine prescription for traditional Chinese medicine acupuncture and a preparation method thereof and belongs to the technical field of traditional Chinese medicine. According to the prescription, astragalus membranaceus and salvia miltiorrhiza are used as a core drug pair, Chinese angelica, ligusticum wallichii and other blood circulation promoting and collateral dredging drugs are matched, safflower (hydroxysafflor yellow A is larger than or equal to 2%) and enzymolysis earthworm (smaller than or equal to 5kDa peptide fragment is larger than or equal to 60%) are used as auxiliary materials to enhance transdermal absorption, and liquorice is used for blending all the drugs. The preparation method comprises the steps of superfine grinding (less than or equal to 50 microns), ultrasonic-alcohol-water combined extraction, gradient vacuum concentration and macroporous resin purification, and can be prepared into dosage forms such as acupoint application gel, enteric-coated tablets and the like. The quality is controlled by combining HPLC fingerprint spectrum with multi-index component determination (astragaloside is greater than or equal to 0.8 mg / g, and tanshinone IIA is greater than or equal to 0.5 mg / g). Experiments show that the dissolution rate of the tanshinone IIA is increased by 49.2% through superfine grinding, the 24-hour transdermal permeation amount of the gel is 3.12 times that of a traditional decoction, the total effective rate of acupuncture and moxibustion combined medication reaches 95.0%, the analgesic and anti-inflammatory effects are remarkably enhanced, and the process is advanced and suitable for industrial production.

Provided are a patch containing colchicine, a preparation method and a use thereof, where the patch includes a polymer matrix layer. The polymer matrix layer includes the following components in weight percentage: 0.1%-5.0% of colchicine, 0.005%-15% of a permeation enhancer, and 80%-99% of a pressure-sensitive adhesive. The patch containing colchicine can achieve transdermal permeation of an amount sufficient for achieving treatment effect, and features no local irritant during pasting and after pasting, no gastrointestinal side effects, and high patient compliance.

This invention belongs to the field of transdermal drug delivery nanocarrier technology, specifically relating to a nanoliposome using coconut oil as the lipid matrix and a specific Li medicinal herb composition (Alpinia oxyphylla + Artemisia argyi + Patchouli) as a natural penetration enhancer, and its preparation method. This product is a derivative of the core patent "A Natural Transdermal Permeation Enhancer Composition Based on Hainan Li Medicinal Herbs and Its Application" (patent application number: 2026106311990), used to significantly improve the transdermal efficiency and skin retention of the penetration enhancer composition, suitable for topical drugs and functional skin care products, realizing the industrialization extension of the core patent technology.