26 results about "Chrysanthemum indicum" patented technology

The invention belongs to the technical field of genetic engineering, and particularly relates to an agrobacterium rhizogenes-mediated coastal chrysanthemum indicum tissue culture-free genetic transformation method and application thereof in enhancing the salt tolerance of a root system. The agrobacterium rhizogenes-mediated coastal chrysanthemum indicum tissue culture-free genetic transformation method comprises the following steps: transfecting agrobacterium rhizogenes with plasmids containing to-be-transformed gene expression cassettes to obtain recombinant agrobacterium rhizogenes, transfecting stems with terminal buds of coastal chrysanthemum indicum with the recombinant agrobacterium rhizogenes, and then cutting. The method provided by the invention is short in required period, and the transgenic plant can be obtained only in 30-60 days. The problems of long chrysanthemum conversion rate period, complex operation and tedious process are solved. A tissue culture mode is not needed, so that the tedious process of tissue culture is reduced; local materials can be used according to the characteristic of cutting rooting of chrysanthemum, chrysanthemum seedlings do not need to be cultivated from seeds, and time cost is reduced.

The present application relates to the technical field of plant breeding, and discloses a wild chrysanthemum standardization propagation method, which comprises the following steps: selecting a wild chrysanthemum single plant, establishing a seed orchard, carrying out 'water-soluble gel incubation' sowing, ecological cultivation and harvesting. The present application significantly improves the medicinal material production efficiency in the natural distribution area of wild chrysanthemum, improves the germination rate, seedling emergence rate and seedling emergence uniformity of wild chrysanthemum, greatly meets the product consistency required by large-scale production, and improves the product excellent rate.

The invention belongs to the technical field of biological medicines, and particularly relates to a compound protein preparation for preventing and treating avian influenza and a preparation method thereof. The compound protein preparation is prepared from the following raw materials in parts by weight: 5 to 10 parts of immune globulin, 15 to 19 parts of radix puerariae, 10 to 15 parts of buchnera macrocarpa, 8 to 12 parts of dendranthema morifolium, 7 to 10 parts of honeysuckle flower, 3 to 10 parts of radix astragali seu hedysari, 2 to 8 parts of echinacea purpurea, 1 to 7 parts of semen cuscutae and 2 to 5 parts of liquorice root. By taking the compound protein preparation for preventing and treating the avian influenza, clinical symptoms caused by the avian influenza can be effectively relieved, and the health level of animals is improved; the vaccine-induced immune response can be effectively enhanced, so that the avian influenza antibody level of animals is improved, the avian influenza is effectively prevented and treated, and the vaccine has a wide application prospect.

The invention provides a bacterial composition and chrysanthemum indicum seed fermentation liquor. The bacterial composition comprises at least two of plant lactobacillus, Witzia ciliaris and plant lactobacillus pentosus. The preservation date of the plant lactobacillus is April 25, 2025, and the preservation number of the plant lactobacillus is CGMCC (China General Microbiological Culture Collection Center) No.34339; the preservation date of the Witzia ciliaris is April 25, 2025, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.34338; the preservation date of the lactobacillus pentosus is May 9, 2025, and the preservation number of the lactobacillus pentosus is CGMCC (China General Microbiological Culture Collection Center) No.34471; the chrysanthemum indicum bud fermentation liquor is obtained by inoculating a bacterial composition into a chrysanthemum indicum bud stock solution for fermentation; the bacterium composition promotes the chrysanthemum indicum bud stock solution to be fermented, so that the effective components in the chrysanthemum indicum bud stock solution are greatly increased.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a formula for preventing and treating new crown, influenza A and cold, which comprises the following components by weight: 12-17g of boat-fruited sterculia seed, 12-17g of grosvenor momordica fruit, 12-17g of dwarf lilyturf tuber, 8-12g of honeysuckle flower, 12-17g of wild chrysanthemum flower, 12-17g of sweet wormwood herb, 18-22g of mint and 12-17g of Chinese mosla herb. The formula disclosed by the invention is used for treating and preventing new crown influenza, influenza A, influenza, viral influenza and common cold, and is effective for pharyngeal pain, oral internal heat and gingival swelling.

This invention provides a combination of medicine and device for treating dental diseases. The method for preparing the medicine is as follows: Boil 1 dan (approximately 50 catties) of cocklebur root and stems, 30 jin (approximately 15 catties) of wild chrysanthemum stems and leaves, and 5 jin (approximately 2.5 kg) of licorice root in a pot until thoroughly cooked. Remove the dregs, and bring the remaining liquid to a boil over high heat, then simmer over low heat until it becomes a paste. When the paste is about 70% cooked, for the treatment of gingivitis and periodontitis, add 100g of indigo naturalis, 50g of mirabilite, 150g of borax, 100g of gypsum, and an appropriate amount of edible preservative. Set aside when fully cooked. For the treatment of toothache, when the paste is about 70% cooked, add 50g of asarum, 100g of angelica dahurica, 100g of Sichuan pepper, 50g of bee honeycomb, 50g of rosin, 100g of borax, 50g of gypsum, and an appropriate amount of edible preservative. (These herbs should be pulverized before being added.) Set aside when fully cooked. The treatment device is a long, narrow, isosceles trapezoid with a hollowed-out center and top base, leaving a wall thickness of 0.2-0.4 mm. The device's dimensions are: base 13 mm, sides 13 mm, and length 18 mm. It can be made of metal or non-toxic plastic. A strip of cloth of the corresponding size is attached to the device, and the prepared ointment is applied to the cloth. When using it, the ointment-coated device is placed on the affected area, ensuring close contact with the lesion and maximizing the medication's effectiveness.

The invention relates to the technical field of health-care food, in particular to a sea cucumber peptide solid beverage capable of enhancing immunity and a production process of the sea cucumber peptide solid beverage. The sea cucumber peptide health-care food is prepared from the following raw materials: more than or equal to 50% of sea cucumber peptide, more than or equal to 10.55% of rhizoma polygonati powder, more than or equal to 5% of fructus lycii powder, more than or equal to 5% of mulberry powder, more than or equal to 4% of herba cistanche powder, more than or equal to 1% of eucommia male pollen, more than or equal to 1% of gynura procumbens powder, more than or equal to 1% of ginseng powder, more than or equal to 0.5% of maca powder and Through scientific compatibility of the sea cucumber peptide, the rhizoma polygonati, the herba cistanche and other components, the content of lactic acid and malondialdehyde can be reduced, the testosterone level of serum and the sperm quality can be remarkably improved, deep synergy of fatigue resistance, oxidation resistance and improvement of male physiological indexes is achieved, the small molecule characteristic that the high-content sea cucumber peptide is easily absorbed by intestinal tracts is utilized, and the health care effect is achieved. And in cooperation with protein and rich B vitamins and minerals, the quick conversion requirement of organisms on high-concentration nutrients is effectively met.

This invention discloses a green control method for tomato viral diseases based on the synergistic effect of Solanaceae and Asteraceae weeds, belonging to the field of agricultural plant crop protection technology. This invention uses the Solanaceae weed *Solanum nigrum* and the Asteraceae weed *Chrysanthemum indicum* as indicator plants for tomato viral diseases. By arranging the indicator plants in a grid pattern, comprehensive monitoring of major viral disease species within the facility can be achieved. By monitoring the viral disease symptoms of the indicator plants, early warnings can be issued 7-10 days in advance, allowing more time for tomato disease control and improving the timeliness and proactivity of prevention and control. Furthermore, based on the warnings issued by the indicator plants, an extract of *Eupatorium fortunei*, an Asteraceae weed that has a significant inhibitory effect on tomato viral disease symptoms, is applied, thus constructing an integrated "monitoring-blocking" green control system, achieving early warning and efficient control of viral diseases.

This invention provides a moisturizing, repairing, and anti-allergic composition containing Cornus officinalis extract and its application, relating to the field of cosmetic technology. The composition comprises the following ingredients: Cornus officinalis extract, beetroot extract, *Prickly pear* fruit extract, *Chrysanthemum indicum* extract, and carboxymethyl deacetylated chitosan. This invention overcomes the limitations of traditional repair products that rely on only a single ingredient. Through a synergistic five-component system of Cornus officinalis extract, carboxymethyl deacetylated chitosan, beetroot extract, *Prickly pear* fruit extract, and *Chrysanthemum indicum* extract, it simultaneously achieves moisturizing, water-locking, barrier repair, and soothing and anti-allergic effects, and is suitable for various sensitive skin types, being gentle and safe.

The invention relates to the technical field of biology, in particular to a molecular marker related to the content of linarin in chrysanthemum indicum, a primer and application of the molecular marker. The molecular marker provided by the invention is located in an active enzyme which directly participates in the last step of a linarin synthesis step, and can more directly, accurately and quickly identify whether the linarin content in a chrysanthemum indicum variety is high or low. The invention also provides a method for detecting chrysanthemum indicum with high linarin content or chrysanthemum indicum with low linarin content by using the molecular marker, the operation is simple and easy, the result is stable and reliable, and a technical guarantee is provided for the protection of germplasm resources and new varieties of chrysanthemum indicum.

This invention provides a yin-nourishing and blood-tonifying medicinal composition, its preparation method, and its application, belonging to the technical field of traditional Chinese medicine compositions. The active ingredients of this composition are prepared from the following raw materials in parts by weight: Astragalus membranaceus 2-3 parts, Angelica sinensis 12-18 parts, Crataegus pinnatifida 2-3 parts, Glycyrrhiza uralensis 2-5 parts, Chrysanthemum indicum 5-9 parts, Melon japonica 20-30 parts, Lemon 15-19 parts, Fine corn flour 2-3 parts, and Whole milk powder 40-44 parts, wherein the weight ratio of Angelica sinensis to Astragalus membranaceus is (6-9):1. The composition of this invention can be prepared into various oral preparations using conventional pharmaceutical processes. The preparation process is stable and controllable, suitable for industrial production. This composition possesses the effects of nourishing yin and blood, strengthening the spleen and promoting digestion, is safe with no toxic side effects, and has an excellent taste. It can be used to prepare drugs for treating and improving yin and blood deficiency syndromes, and has good clinical application and industrialization prospects.

This invention discloses a traditional Chinese medicine composition for the prevention and / or treatment of herpes and / or its complications. By weight, the composition comprises: 8-14 parts of Sophora flavescens, 5-11 parts of Bistorta officinalis, 9-15 parts of Rheum palmatum, 0.5-6 parts of Coptis chinensis, 1-7 parts of Forsythia suspensa, 1-7 parts of Taraxacum mongolicum, 1-7 parts of Viola yedoensis, 1-7 parts of Paeonia lactiflora, 1-7 parts of Paeonia suffruticosa, 1-7 parts of Gardenia jasminoides, 3-9 parts of Rehmannia glutinosa, 1-7 parts of Chrysanthemum indicum, 1-7 parts of Lonicera japonica, 1-7 parts of Atractylodes lancea, 0.5-6 parts of Phellodendron chinense, 0.5-1.5 parts of Cicadae periostracum, 2-8 parts of Smilax glabra, 1-7 parts of Anemarrhena asphodeloides, 1-7 parts of Ophiopogon japonicus, 0.5-6 parts of Alisma plantago-aquatica, and 1-7 parts of Gypsum fibrosum. The complications are pain and / or inflammation. This traditional Chinese medicine composition is safe, effective, and has a simple and efficient preparation method with controllable quality. It also exhibits significant analgesic and anti-inflammatory effects and can treat shingles and its sequelae.

The invention discloses a traditional Chinese medicine composition for treating rhinitis and a preparation method thereof. The traditional Chinese medicine composition comprises traditional Chinese medicine raw materials and functional auxiliary materials, wherein the traditional Chinese medicine raw materials comprise the following medicinal materials in percentage by weight: 12% of biond magnolia flower, 12% of small centipeda herb, 15% of dwarf lilyturf tuber, 3% of wild chrysanthemum flower, 3% of dahurian angelica root, 3% of dandelion, 3% of manchurian wildginger, 3% of cocklebur fruit, 8% of common burreed rhizome, 8% of curcuma zedoary, 10% of red-rooted salvia root, 6% of szechuan lovage rhizome and 6% of thunberg fritillary bulb; the functional auxiliary materials comprise the following raw materials in percentage by weight: 0.4% of cellulase, 0.2% of pectinase, 1.2% of carbomer, 0.8% of poloxamer, 0.1% of glycyrrhetinic acid, 0.05% of limonene, 5.24% of chitosan-sodium alginate and 0.01% of an anti-VEGF antibody. According to the application, a nasal polyp targeting component is added, so that the dual effects of dredging orifices, resisting inflammation (rhinitis) and resisting fiber (nasal polyp) are realized; the clinical value is higher than that of single rhinitis treatment; plant cell walls are destroyed by adopting composite enzymolysis, and fat-soluble, water-soluble and volatile oil active ingredients are synchronously extracted in combination with supercritical CO2 extraction; the mucous membrane stimulation risk caused by impurities is reduced.

The present application provides a bacterial composition and wild chrysanthemum rice fermentation liquor, the bacterial composition comprises at least two of lactobacillus plantarum, weizmannia conjuncta and lactobacillus pentosus; the preservation date of lactobacillus plantarum is April 25, 2025, and the preservation number is CGMCC No.34339; the preservation date of weizmannia conjuncta is April 25, 2025, and the preservation number is CGMCC No.34338; the preservation date of lactobacillus pentosus is May 9, 2025, and the preservation number is CGMCC No.34471; the wild chrysanthemum rice fermentation liquor is obtained by inoculating the bacterial composition into wild chrysanthemum rice stock solution for fermentation; the bacterial composition promotes the wild chrysanthemum rice stock solution to greatly improve the effective components therein through fermentation.

The invention discloses a formula and a preparation process of a Chinese herbal medicine animal feed, and belongs to the technical field of animal feed preparation, the Chinese herbal medicine animal feed comprises the following raw materials in parts by weight: a core health-care formula: 20-30 parts of radix astragali, 15-25 parts of radix astragali, 10-20 parts of hawthorn, 10-20 parts of malt, 8-15 parts of pericarpium citri reticulatae, 15-20 parts of malt, 3-6 parts of fennel, 3-6 parts of anise and 3-6 parts of myrcia; and the immunological enhancement formula comprises 8 to 15 parts of honeysuckle flower, 5 to 12 parts of wild chrysanthemum flower, 8 to 15 parts of isatis root, 12 to 15 parts of lucid ganoderma, 6 to 10 parts of tsaoko amomum fruit, 15 to 20 parts of motherwort herb, 15 to 20 parts of medicated leaven and 15 to 20 parts of beautiful millettia root. According to the invention, a biochemical method of'synergistic extraction-concentration preparation 'is adopted, and active ingredients in the medicinal materials are extracted and concentrated to the greatest extent in advance in vitro, so that the herbal medicine raw materials are upgraded into high-concentration active extracts, and animals can directly, quickly and efficiently absorb the active ingredients, therefore, the additive amount is small, and the cost is low. And the effect is more obvious and quicker.

The invention provides a plant extraction compound factor with anti-inflammatory and anti-allergy functions and a preparation method thereof, and relates to the technical field of skin care product processing, the plant extraction compound factor is prepared from the following raw materials by weight: 8-10 parts of gentiana macrophylla, 5-7 parts of swertia mileensis, 4-6 parts of stephania tetrandra, 6-8 parts of phellinus igniarius, and 7-9 parts of peony. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 5-7 parts of eucommia ulmoides, 4-6 parts of magnolia sieboldii, 6-8 parts of andrographis paniculata and 3-5 parts of polygala tenuifolia, and the plant extraction compound factor is prepared from the following raw materials in parts by weight: 8-10 parts of centella asiatica, 3-5 parts of bamboo shavings, 5-7 parts of fructus forsythiae and 4-6 parts of amur corktree. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 3-5 parts of coreopsis tinctoria, 7-9 parts of liquorice, 2-4 parts of pelargonium graveolens and 3-5 parts of broom leaf Australian tea.

The invention provides a traditional Chinese medicine composition for treating atopic dermatitis, a pharmaceutical preparation and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition comprises philippine violet herb, divaricate saposhnikovia root, belvedere fruit, eucalyptus leaf, dandelion, wild chrysanthemum flower, mirabilite, amur corktree bark and pulvis fellis suis. The traditional Chinese medicine composition and the pharmaceutical preparation provided by the invention not only can clear away heat toxins of skin, dispel wind pathogens, eliminate dampness and relieve itching, but also take mild skin care into account, adapt to pathogenesis of atopic dermatitis and external administration requirements, take effect directly, are controllable in safety, and have a good treatment effect on atopic dermatitis.

The invention relates to the technical field of agriculture and forestry, and discloses a chrysanthemum indicum cutting rooting method. The invention provides a chrysanthemum indicum cutting rooting method. The chrysanthemum indicum cutting rooting method comprises the following steps: S1, soaking cutting slips subjected to primary cutting in a mixed aqueous solution of a rooting agent and a bactericide, and then inserting the cutting slips into a hole tray filled with a cutting medium for cutting seedling raising; s2, spraying water during cutting seedling raising, transplanting 15 days after cutting, or performing topping to obtain terminal buds 25 days after cutting and / or after cutting seedlings are higher than 20cm, and transplanting the topped cutting seedlings; the terminal buds obtained through topping serve as cutting slips for secondary cutting, and the step S1 is repeated for secondary cutting seedling raising. According to the cutting rooting method, rapid propagation of wild chrysanthemum flowers can be achieved, obtained cutting seedlings have the good rooting rate and root length, the quality of new seedlings is guaranteed, secondary cutting can be continued, the propagation coefficient of mother plants of the wild chrysanthemum flowers is increased, the time for obtaining cutting slips is shortened, and the cost for obtaining the cutting slips is saved.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and application thereof in preparation of an antiviral medicine. The present application comprises honeysuckle, stevia leaf, wild chrysanthemum, isatis leaf and osmanthus, and the traditional Chinese medicine composition obtained thereby contains rich plant microRNA, MIR2911, thereby playing a good antiviral effect. Moreover, due to the negative effect of a flavoring agent on active ingredients in a product, the present application improves the prescription, and on the basis of avoiding the addition of a flavoring agent and a preservative, the product of the prescription obtains a good taste and can maintain stable quality for several months.

The invention provides a traditional Chinese medicine preparation for improving the cold treatment effect, namely a cold virus killing agent. The preparation method comprises the following steps: selecting several traditional Chinese medicinal materials with disinfection, sterilization and anti-inflammation functions, namely chrysanthemum indicum, asarum, coptis chinensis, scutellaria baicalensis, pepper, isatis root and liquorice, adding water, boiling twice, mixing the medicine liquids obtained by decocting twice, adding edible white vinegar accounting for 10% of the total medicine amount and an edible preservative accounting for 1% of the total medicine amount, and uniformly stirring. Viruses and bacteria in the nasal cavity can be directly killed; the main path of cold infection is the respiratory tract, the nasal cavity is the leading edge of virus infection, and then cold enters the whole body to cause morbidity; during treatment, the anti-cold drug is orally taken, the drug efficacy spreads all over the whole body, viruses can be quickly killed, but the drug efficacy of nasal mucosa and nasal liquid is difficult to enter, and at the moment, the nasal cavity becomes the base of the anti-cold drug from the leading edge of infection; at the moment, viruses in the nasal cavity can be killed by applying the cold virus killing agent to the nasal cavity, so that the treatment time is saved; the preparation is applied locally, and the efficacy of the preparation cannot reach the whole body, so that a patient must take at least one cold medicine when using the preparation, the cold virus killing agent can be independently used for treating rhinitis, but three medicines, namely magnolia flower, divaricate saposhnikovia root and solidago decurrens, for treating rhinitis must be added.

This invention discloses a lung-nourishing Solomon's Seal Ointment, its preparation method, and its application, relating to the field of traditional Chinese medicine technology. The herbal composition comprises three herbs: Herb A, Herb B, and Herb C. Herb A includes Solomon's Seal, Lycium barbarum, Chrysanthemum indicum, Mulberry fruit, White peony root, Rehmannia glutinosa, Raw Chinese yam, Ziziphus jujuba peel, Moutan bark, and Poria cocos. Herb B includes Achyranthes bidentata, Polygonatum sibiricum (processed with wine), Ophiopogon japonicus, Adenophora stricta, Tangerine peel, Prepared licorice root, Astragalus membranaceus, and Anemarrhena asphodeloides. The lung-nourishing Solomon's Seal Ointment is prepared by combining Herbs A and B in the herbal composition, decocting them in water, filtering the filtrate, concentrating the liquid, adding Herb C to dissolve, and then simmering over low heat to form an ointment. This technical solution is applied to the treatment of chronic obstructive pulmonary disease (COPD), forming a multi-target, holistic conditioning system. It provides crucial synergistic value to Western medicine's strategy of simply controlling symptoms in improving chronic COPD symptoms and enhancing quality of life, thereby improving the quality of life for COPD patients.

Abstract: This invention discloses a traditional Chinese medicine composition (Da Zhuque Decoction) with multi-target antiviral and anti-inflammatory activities, its preparation method, and its application. The composition consists of the following raw materials in parts by weight: Alisma plantago-aquatica 2-4 parts, Prunus armeniaca 4-6 parts, Chrysanthemum indicum 4-6 parts, Artemisia annua 5-7 parts, Morus alba leaf 5-7 parts, Gypsum 5-7 parts, Poria cocos 7-9 parts, Scutellaria baicalensis 8-10 parts, Rehmannia glutinosa 8-10 parts, Plantago asiatica 11-13 parts, Taraxacum mongolicum 14-16 parts, and Glycyrrhiza uralensis 3-5 parts. This invention overcomes the limitations of traditional qualitative formulation of traditional Chinese medicines. By limiting the specific synergistic ratio of artemisinin and baicalin (1:2.5~3.0), it achieves highly efficient inhibition of respiratory viruses (IC50=12.5μg / mL) and significant downregulation of inflammatory factors (IL-6, TNF-α). Meanwhile, the preparation process of "plaster decoction first - licorice extraction alone" solves the problem of easy decomposition of heat-sensitive components, increasing the artemisinin retention rate to over 95%. This invention has a clear material basis, controllable quality, and is suitable for preparing drugs or health products for the prevention and treatment of viral pneumonia.

The invention belongs to the technical field of plant genetic engineering, and particularly relates to a chrysanthemum indicum CzNAC1 gene and application thereof. The invention discloses a chrysanthemum indicum CzNAC1 gene. The nucleotide sequence of the chrysanthemum indicum CzNAC1 gene is shown as SEQ ID NO. 1. According to the invention, transcriptome data is screened and cloned to the drought-responsive CzNAC1 gene, a carrier is constructed, and a transgenic plant is cultivated, so that the cultivation of a specific variety of transgenic chrysanthemum indicum, drought resistance conditions, economic and social benefits increase, stress-resistant genes are explored, gene resource mining and cross-species application are further promoted, and the application prospect is wide. And a good basis is provided for subsequent gene technology research.

The invention discloses a medicinal and edible dual-purpose composition which is prepared from eucommia ulmoides leaves, cyclocarya paliurus leaves, mulberry leaves, lotus leaves, angelica keiskei, golden camellia leaves and cinnamon according to the mass ratio of 4: 3: 3: 2: 2: 2: 2. The preparation method comprises the following steps: S1, raw material treatment; s2, extracting; and S3, filtering. The invention also discloses an application of the traditional Chinese medicine composition in preparation of hypoglycemic health-care food. The medicinal and edible dual-purpose composition disclosed by the invention has a relatively good hypoglycemic effect on type 2 diabetes mellitus, can reduce the blood sugar level and improve the blood sugar fluctuation, and also has the effects of resisting oxidation and protecting organs; the health-care food prepared from the medicinal and edible dual-purpose composition can reduce the blood sugar level and improve the safety at the same time, and has a good flavor at the same time.

The application discloses application of a wild chrysanthemum essential oil effective component combination in preparation of a medicine for preventing and treating acute lung injury, and particularly relates to the technical field of biological medicines, wherein the wild chrysanthemum essential oil effective component comprises beta-farnesene, 4-terpenol, artemisia oil, wild chrysanthemum alcohol and carvomenthone, and in an acute lung injury model, the wild chrysanthemum essential oil effective component can significantly regulate the survival state of lung epithelial cells, improve the phenomenon of cell activity decline, and effectively maintain the stability of mitochondrial membrane potential (Delta Psi m). In an acute lung injury mouse model, the wild chrysanthemum essential oil effective component combination can significantly improve the pathological injury of lung tissue, and significantly inhibit the expression of inflammatory mediators in bronchoalveolar lavage fluid (BALF). In summary, the wild chrysanthemum essential oil effective component combination can be applied in preparation of an anti-acute lung injury medicine.

This invention discloses a *Chrysanthemum indicum* extract and its application in cosmetics, belonging to the field of cosmetic technology. The extract is a *Chrysanthemum indicum* polysaccharide that has undergone acetylation-fucosylation dual modification, prepared through water extraction and alcohol precipitation, enzymatic acetylation, and carbodiimide-mediated grafting of fucose. This targeted modified extract is then compounded with fructooligosaccharides, β-glucan, dipotassium glycyrrhizate derivatives, and asiaticoside to prepare a chitosan-algin bilayer structure for layered release microcapsule gel. The extract of this invention can target and regulate the skin's microecology, and the composition possesses anti-inflammatory, soothing, barrier-repairing, and slow-release effects, is gentle and non-irritating, and suitable for sensitive skin care. This invention solves the problems of weak targeting, single efficacy, and poor stability in traditional prebiotic cosmetics, with controllable process and promising application prospects.