Traditional Chinese medicine composition for treating rhinitis, preparation and preparation method

Abstract

The invention relates to a traditional Chinese medicine composition for treating rhinitis, a preparation and a preparation method, and relates to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components in parts by weight: 5-20 parts of fructus xanthii; 5-20 parts by weight of citronella; 3-15 parts by weight of cacumen biotae; 3-15 parts by weight of sweet almond; 4-18 parts by weight of mulberry leaves; 5-20 parts by weight of Tianshan ice chrysanthemum; 5-20 parts by weight of wild chrysanthemum flower; 5-20 parts by weight of folium apocyni veneti; 4-18 parts by weight of fritillaria pallidiflora; and 2-10 parts by weight of sea buckthorn fruit oil. According to the traditional Chinese medicine composition, through reasonable compatibility of the components, the effects of relieving stuffy nose, resisting inflammation, moistening dryness, regulating body fluid and the like can be achieved, and the traditional Chinese medicine composition has good treatment and improvement effects on acute rhinitis, allergic rhinitis and chronic hypertrophic rhinitis.

Description

Technical Field

[0001] The present application relates to the field of traditional Chinese medicine, and more specifically, to a traditional Chinese medicine composition, preparation, and preparation method for treating rhinitis. Background Art

[0002] Rhinitis refers to inflammation of the nasal mucosa or submucosal tissue, which can be caused by a variety of factors, including allergies, infections, and environmental irritants. Types of rhinitis include allergic rhinitis, chronic rhinitis, acute rhinitis, medication-induced rhinitis, and dry rhinitis. Symptoms of rhinitis include nasal congestion, runny nose, sneezing, and headaches. Although rhinitis is a common condition, it can lead to a variety of health problems if left untreated.

[0003] At present, the treatment methods for rhinitis at home and abroad mostly use drug treatment, such as nasal corticosteroids (such as mometasone furoate, budesonide, etc.), oral or nasal anti-inflammatory drugs (such as loratadine, cetirizine, etc.); although the above drugs have fast efficacy, there are problems such as the symptoms are prone to recurrence after discontinuation of the drugs. Summary of the Invention

[0004] In order to solve the above technical problems, the present application provides a traditional Chinese medicine composition for treating rhinitis and a preparation method thereof.

[0005] According to the first aspect of the present application, a Chinese medicine composition for treating rhinitis is provided, which adopts the following technical solution:

[0006] A traditional Chinese medicine composition for treating rhinitis, comprising the following components in parts by weight:

[0007]

[0008]

[0009] In some embodiments, the Chinese medicine composition further comprises the following components in parts by weight:

[0010]

[0011] In some embodiments, the Chinese medicine composition further comprises the following components in parts by weight:

[0012] 4-18 parts by weight of Rhodiola rosea;

[0013] 3-15 parts by weight of snow lotus heart.

[0014] In some embodiments, the Chinese medicine composition further comprises:

[0015] 5-10 parts by weight of honey;

[0016] And / or, the Chinese medicine composition further comprises:

[0017] 6-12 parts by weight of liquorice.

[0018] According to a second aspect of the present application, a preparation for treating rhinitis is provided, the preparation comprising any one of the above-described traditional Chinese medicine compositions and excipients;

[0019] The weight ratio of the traditional Chinese medicine composition to the auxiliary material is 1:1.0-1.5.

[0020] In some embodiments, the auxiliary material includes refined honey.

[0021] In some embodiments, the preparation further comprises a lubricant, and the weight of the lubricant is 5.0-10.0% by weight of the traditional Chinese medicine composition.

[0022] In some embodiments, the formulation has a water content of 18% or less.

[0023] According to a third aspect of the present application, there is provided a method for preparing any one of the above preparations for treating rhinitis, the method comprising:

[0024] Drying, crushing, and sieving the traditional Chinese medicine composition to obtain a powder with a fineness of 80-200 mesh;

[0025] The medicinal powder is mixed with the auxiliary materials to prepare the preparation.

[0026] According to a fourth aspect of the present application, a preparation for treating rhinitis is provided, characterized in that the preparation comprises volatile oil and a solvent, and the volatile oil is extracted from any one of the above-mentioned traditional Chinese medicine compositions;

[0027] The weight ratio of the volatile oil to the solvent is 1:10-30.

[0028] In summary, this application has the following beneficial effects:

[0029] 1. This application uses Xanthium sibiricum, citronella, Platycladus orientalis leaves, sweet almonds, mulberry leaves, Tianshan ice chrysanthemum, wild chrysanthemum, Apocynum venetum leaves, Ili Fritillaria, and sea buckthorn fruit oil as basic components. Through the reasonable combination of the above components, it can play the role of clearing the nasal orifices, anti-inflammatory, moisturizing, and regulating body fluids. It has a good therapeutic and improvement effect on acute rhinitis, allergic rhinitis, and chronic hypertrophic rhinitis.

[0030] 2. This application adjusts the formula and adds synergistic components such as peppermint oil, angelica dahurica, melon vine, Fritillaria wuqia, and Gobi parsnip to the basic components. Through the synergistic cooperation of the above-mentioned synergistic components and the basic components, it has a good therapeutic and improvement effect on long-term rhinitis.

[0031] 3. This application adjusts the formula and adds optimized components such as Rhodiola rosea and snow lotus heart on the basis of basic components and synergistic components. Through the synergistic cooperation of the above-mentioned optimized components with the basic components and synergistic components, it has a good therapeutic and improvement effect on recurrent chronic rhinitis.

[0032] 4. The Chinese medicine composition of the present application can be used to prepare honey pills or dew. The honey pills can be used for oral administration, and the dew can be dripped or sprayed into the nasal cavity, which can effectively relieve various symptoms caused by rhinitis. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the present application will be clearly and completely described below in conjunction with the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present application. It should be noted that, in the absence of conflict, the embodiments in the present application and the features in the embodiments can be arbitrarily combined with each other.

[0034] In some exemplary embodiments, a traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight:

[0035]

[0036]

[0037] This application is based on Uyghur medical theory and adds authentic Xinjiang medicinal materials, such as Tianshan ice chrysanthemum, Apocynum venetum leaves, Ili Fritillaria, etc. Through the reasonable combination of the efficacy of Chinese medicinal materials, it plays the role of clearing the nasal passages, anti-inflammatory, moisturizing, regulating body fluids, etc., so as to achieve the purpose of treating rhinitis.

[0038] The following is an explanation of the core efficacy, Uyghur medical theoretical basis and indications of each component in the traditional Chinese medicine composition.

[0039] The core benefits of Xanthium sibiricum include clearing the nasal passages, dispelling wind and cold, removing rheumatism, dredging the meridians and relieving pain, as well as providing antibacterial, anti-inflammatory, and anti-allergic properties. In Uyghur medicine, Xanthium sibiricum is classified as a "hot, dry" herb, reflecting its pungent, warm, and damp-drying properties. It is suitable for constitutions with cold and dampness, as well as for conditions affected by wind, cold, and dampness. Xanthium sibiricum can enhance heat-clearing and orifice-opening effects, and is particularly effective for treating purulent nasal discharge caused by acute sinusitis. Before consumption, Xanthium sibiricum should be stir-fried until dark brown, soaked in water, and then pinched to remove the raw core to reduce its toxicity.

[0040] According to the humoral theory of Uyghur medicine, humors are derived from temperament. The human body has four normal humors: blood, choleric, phlegmatic, and black bile, corresponding to the sanguine, choleric, phlegmatic, and melancholic temperaments, respectively. When these four humors are in balance, the body exhibits health, vitality, emotional stability, and normal physiological function. Disruption of this balance can lead to various illnesses. Lemongrass' core benefits include dispelling wind and cold, dredging meridians and relieving pain, and providing antibacterial, anti-inflammatory, and antiviral properties. Lemongrass balances these four humors. Uyghur medicine believes that lemongrass is warming and drying, and excessive consumption can easily damage yin fluids. Therefore, it is important to control its dosage or combine it with "corrective" herbs to mitigate adverse reactions and enhance therapeutic efficacy. Lemongrass can enhance its wind-dispelling and anti-allergic properties, reducing nasal mucosal sensitivity.

[0041] The core benefit of Platycladus orientalis leaf is its antibacterial and anti-inflammatory properties. Uyghur medicine classifies Platycladus orientalis leaf as a "cold, dry" herb, reflecting its heat-clearing and blood-cooling properties, making it suitable for febrile conditions. Platycladus orientalis leaf can also enhance its anti-allergic and anti-allergic properties, reducing nasal mucosal sensitivity.

[0042] Sweet almonds' core benefits include moistening the lungs, relieving coughs, alleviating asthma and dryness, regulating immunity, and regulating body fluids. Sweet almonds' moisturizing properties target "dry body fluids" (similar to insufficient body fluids in Traditional Chinese Medicine) and alleviate dry coughs. They can also alleviate dryness and rhinitis caused by dryness.

[0043] The core benefits of mulberry leaf include dispersing wind-heat, clearing the lungs and moistening dryness, and providing antiviral and antibacterial properties. Mulberry leaf can regulate black bile and balance bile; it is suitable for dry rhinitis.

[0044] Tianshan Ice Chrysanthemum, also known as Tianshan Snow Chrysanthemum, Kunlun Snow Chrysanthemum, and Iceberg Snow Chrysanthemum, is a rare wild chrysanthemum that grows at high altitudes in the Tianshan Mountains of Xinjiang. It contains flavonoids (such as luteolin) that have superior antibacterial properties to common chrysanthemums. Its core benefits are clearing heat and detoxifying, reducing swelling and relieving constipation. In Uyghur medicine, Tianshan Ice Chrysanthemum is used to treat "heat-induced nasal sinusitis" and inhibit nasal bacteria (such as Staphylococcus aureus). It is also suitable for acute rhinitis and sinusitis.

[0045] The core benefits of wild chrysanthemum are dispelling wind and heat, and providing antibacterial and anti-inflammatory properties. Wild chrysanthemum can inhibit nasal inflammatory factors (such as IL-6 and TNFα), and synergistically enhances the therapeutic effect of xanthium sibiricum. It is suitable for allergic rhinitis (cold syndrome).

[0046] Apocynum venetum leaf is primarily produced in the Lop Nur region of Xinjiang, earning it the nickname "Xinjiang Specialty." Its core benefits include calming the liver, extinguishing wind, and improving microcirculation. It can regulate "abnormal black bile," relieving nasal headaches and nasal dryness, and is suitable for chronic hypertrophic rhinitis. However, due to its blood-activating properties, its use should be avoided during acute nasal bleeding.

[0047] Ili Fritillaria, also known as Xinjiang Fritillaria, is primarily produced in Ili, Huocheng, Yining, Chabuchaer, Wenquan, and Bole, Xinjiang. Its core benefits are moistening the lungs, reducing phlegm, and repairing mucosal membranes. It can repair damaged nasal mucosa and reduce secretions, acting like a mucus regulator. It is suitable for treating dry and atrophic rhinitis.

[0048] Seabuckthorn berries are primarily produced in the Altay region of northern Xinjiang. Seabuckthorn berry oil, a natural oil extracted from the fruit, is rich in unsaturated fatty acids, antioxidants like vitamin C, and anti-inflammatory compounds like flavonoids. Its core benefits include moisturizing the mucous membranes and providing antioxidant benefits. It can repair the nasal mucosal barrier and reduce oxidative stress damage, making it suitable for dry rhinitis and rhinitis medicamentosa. Extraction of seabuckthorn berry oil requires low temperatures (≤60°C) to prevent oxidation of its active ingredients.

[0049] When adjusting the ingredients and dosage of traditional Chinese medicine formulas, it's important to consider the toxicity and incompatibility of the herbs. For example, Apocynum venetum leaf is slightly toxic, so its dosage needs to be controlled. Seabuckthorn berry oil may interact with the sour flavor of lemongrass, so the ratio between the two may need to be adjusted.

[0050] Furthermore, combining two or more ingredients can create a synergistic effect, enhancing efficacy. For example, wild chrysanthemum and apocynum venetum leaf, when combined, have a synergistic effect of clearing heat and calming the liver, improving nasal microcirculation and inflammatory responses. Ili beemi combined with sea buckthorn fruit oil can promote mucosal regeneration and repair mucosal atrophy caused by hormones or antibiotics.

[0051] Furthermore, the Chinese medicine composition includes the following components in parts by weight:

[0052]

[0053]

[0054] Preferably, the Chinese medicine composition comprises the following components in parts by weight:

[0055]

[0056] For example, in one embodiment, the Chinese medicine composition includes the following components in parts by weight:

[0057]

[0058] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0059] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0060] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0061]

[0062] The key components of the traditional Chinese medicine composition of the above embodiment can be used for the basic treatment of rhinitis, and can be used for acute rhinitis, acute sinusitis, allergic rhinitis, dry rhinitis, atrophic rhinitis, rhinitis medicamentosa, etc. For long-term rhinitis, the synergistic component can be added to significantly relieve the symptoms in a short period of time.

[0063] Based on this, in some exemplary embodiments, the Chinese medicine composition further includes the following components in parts by weight:

[0064]

[0065] In this embodiment, peppermint oil, angelica dahurica, cucurbit vine, wuqia fritillaria, and gobi parsnip can be used as synergistic components to improve the therapeutic effect of long-term rhinitis.

[0066] The following is an explanation of the core efficacy, Uyghur medical theoretical basis and indications of the synergistic components in the traditional Chinese medicine composition.

[0067] Peppermint oil is a volatile essential oil distilled from the entire mint plant. It contains ingredients such as menthol, menthone, and menthyl acetate. Its core benefits are extinguishing fire, moisturizing dryness, and clearing away heat and detoxifying. Angelica dahurica's core benefits are extinguishing fire, moisturizing dryness, and clearing away heat and detoxifying. Melon vines' core benefits are clearing away heat and detoxifying, as well as regulating immunity. Melon vines, including cucumber vines (water) and pumpkin vines (earth), balance choleric (heat) constitutions. Peppermint oil, Angelica dahurica, and melon vines can all reduce heat and dryness, providing a soothing effect.

[0068] Wuqia Fritillaria fuciformis, primarily produced in the Kashgar region of Xinjiang, is known for its cough and asthma-relieving properties. Its high content of alkaloids (such as fritillaryin A) has a significant antihistamine effect, inhibiting histamine release and relieving allergic rhinitis, nasal itching, and sneezing. It is suitable for allergic rhinitis. The recommended daily dosage should not exceed 6g, as excessive intake may cause diarrhea.

[0069] Gobi parsnip is a desert plant whose core functions are to dispel wind and relieve exterior symptoms, and to fight allergies. Gobi parsnip is a classic "abnormal mucus clearer" in Uyghur medicine, which can relieve nasal mucosal edema and sneezing. It is suitable for wind-cold rhinitis and allergic rhinitis.

[0070] The core effect of magnolia is to clear the nasal passages and dispel wind and cold. It can directly act on the nasal cavity to relieve symptoms such as nasal congestion and runny nose. It is suitable for acute rhinitis, chronic rhinitis, allergic rhinitis, sinusitis, etc.

[0071] In this embodiment, peppermint oil, angelica dahurica, melon vine, wuqia fritillaria, and gobi parsnip are combined with the basic components in the above embodiments to strengthen the treatment of various types of long-term rhinitis such as allergic rhinitis and wind-cold rhinitis.

[0072] Furthermore, the Chinese medicine composition includes the following components in parts by weight:

[0073]

[0074] Preferably, the Chinese medicine composition comprises the following components in parts by weight:

[0075]

[0076]

[0077] For example, in one embodiment, the Chinese medicine composition includes the following components in parts by weight:

[0078] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0079]

[0080] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0081]

[0082] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0083]

[0084] By combining the basic components and synergistic components in the above embodiments, it is possible to treat chronic rhinitis that has not been cured for a long time. For recurrent chronic rhinitis, the therapeutic effect of chronic rhinitis can be improved by adding optimized components. In some exemplary embodiments, the Chinese medicine composition further includes the following components in parts by weight:

[0085] 4-18 parts by weight of Rhodiola rosea;

[0086] 3-15 parts by weight of snow lotus heart.

[0087] Rhodiola rosea is a plateau medicinal herb whose core benefits include invigorating Qi and yang, and enhancing immunity. It can boost local nasal immunity and prevent recurrent infections. Furthermore, it can regulate the Th1 / Th2 immune balance and reduce the recurrence of allergic rhinitis. However, due to the risk of elevated blood pressure from the salidrosides it contains, patients with hypertension should use Rhodiola rosea with caution.

[0088] Snow lotus heart, grown on the snow line of the Tianshan Mountains, is used to treat cold humoral rhinitis, alleviating nasal congestion and runny nose exacerbated by cold weather. Combining Rhodiola rosea, snow lotus heart, and other ingredients can be used to treat recurring episodes of chronic rhinitis. For example, combining snow lotus heart with Gobi parsnip can balance cold and hot humors, effectively treating alternating episodes of wind-cold / wind-heat rhinitis.

[0089] Furthermore, the Chinese medicine composition includes the following components in parts by weight:

[0090]

[0091] Preferably, the Chinese medicine composition comprises the following components in parts by weight:

[0092]

[0093]

[0094] For example, in one embodiment, the Chinese medicine composition includes the following components in parts by weight:

[0095]

[0096] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0097] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0098]

[0099] In another embodiment, the Chinese medicine composition comprises the following components in parts by weight:

[0100]

[0101] In some exemplary embodiments, the Chinese medicine composition further comprises:

[0102] 5-10 parts by weight of honey.

[0103] In this embodiment, honey can be used as a corrective drug in the traditional Chinese medicine composition to balance the medicinal properties, alleviate the dryness of the medicine, and reduce side effects. For example, the amount of honey can be 5 parts by weight, 6 parts by weight, 8 parts by weight, or 10 parts by weight.

[0104] In some exemplary embodiments, the Chinese medicine composition further comprises:

[0105] 6-12 parts by weight of liquorice.

[0106] In this embodiment, licorice can also be used as a corrective drug in the traditional Chinese medicine composition to harmonize the medicinal properties, alleviate the dryness of the medicine, and reduce side effects. Exemplarily, the amount of licorice can be 6 parts by weight, 8 parts by weight, 10 parts by weight, or 12 parts by weight.

[0107] The Chinese medicine composition of the present application can be used to treat acute rhinitis, allergic rhinitis, chronic hypertrophic rhinitis, and other conditions; different components can work synergistically to treat different symptoms. For example, for acute rhinitis, the combination of Tianshan Ice Chrysanthemum and Wild Chrysanthemum can quickly provide antibacterial effects; the combination of Xanthium sibiricum and Magnolia officinalis can clear the nasal passages; the Chinese medicine composition of the present application can alleviate nasal congestion in acute rhinitis within three days.

[0108] For allergic rhinitis, the combination of Fritillaria wuqia and Parsnip can inhibit histamine; the combination of snow lotus heart can regulate cold body fluids and reduce sneezing by 70%.

[0109] For chronic hypertrophic rhinitis, the combination of Apocynum venetum and Rhodiola rosea can improve circulation; the combination of sea buckthorn oil can repair the mucosa and reduce the size of the nasal concha after 6 weeks.

[0110] In some exemplary embodiments, a preparation for treating rhinitis is provided, the preparation comprising the Chinese medicine composition according to any one of the above embodiments and excipients;

[0111] The weight ratio of the traditional Chinese medicine composition to the auxiliary materials is 1:1.0-1.5.

[0112] Among them, auxiliary materials include refined honey.

[0113] The preparation in this embodiment can be a honey pill; the auxiliary material can be honey. Honey itself has the effects of moisturizing, detoxifying and replenishing the middle qi, and its combination with the components of the traditional Chinese medicine composition can enhance the therapeutic effect; and because honey is viscous, the honey pill made with honey can gradually dissolve and release in the body, achieving a sustained release effect. Among them, the honey can be selected from high-quality honey such as jujube honey and vitex honey, and its density (15°C) is 1.40-1.45g / cm 3 , few impurities and moderate moisture.

[0114] Because natural honey has a high water content (approximately 17% to 25%), using it directly to make honey pills can result in the pills being too soft and difficult to shape. Therefore, the honey needs to be heated and simmered to reduce the water content, resulting in refined honey. Refined honey includes tender honey (105-110°C), medium honey (116-118°C), and aged honey (119-122°C). Tender honey has a water content of approximately 20% and is suitable for medicinal materials high in sugar and fat; medium honey has a water content of approximately 10% and is suitable for most medicinal materials; and aged honey has a water content of less than 10% and is suitable for medicinal materials high in fiber and minerals. In this embodiment, medium honey can be used for refined honey.

[0115] The weight ratio of the Chinese herbal composition to refined honey can be adjusted based on the season and the fiber content of the medicinal material. For example, the amount of refined honey can be increased in winter and decreased in summer. For Chinese herbal compositions with high fiber content, the amount of refined honey can be increased. For example, the weight ratio of the Chinese herbal composition to refined honey can be 1:1.0, 1:1.2, or 1:1.5.

[0116] In some exemplary embodiments, the preparation further comprises a lubricant, and the weight of the lubricant is 5.0-10.0% by weight of the traditional Chinese medicine composition.

[0117] In this embodiment, the formulation also includes a lubricant, which can facilitate molding and reduce adhesion. Exemplarily, the weight of the lubricant is 5.0%, 6.5%, 7.8%, 8.9%, 9.5%, or 10.0% of the weight of the traditional Chinese medicine composition. The lubricant can include sesame oil and beeswax in a weight ratio of 5.26:1.

[0118] In some exemplary embodiments, the water content of the formulation is 18% or less.

[0119] In this embodiment, the water content of the preparation needs to be less than or equal to 18% to avoid hydrolysis of the Fritillaria components.

[0120] In some exemplary embodiments, a method for preparing a preparation for treating rhinitis according to any of the above embodiments is provided, the method comprising:

[0121] The Chinese medicine composition is dried, crushed, and sieved to obtain a powder with a fineness of 80-200 mesh;

[0122] The drug powder is mixed with excipients to prepare a preparation.

[0123] In this embodiment, the Chinese medicine composition can be dried at a low temperature of 60-80° C. to prevent the volatile components from volatilizing and becoming ineffective.

[0124] In some exemplary embodiments, a preparation for treating rhinitis is provided, the preparation comprising volatile oil and a solvent, wherein the volatile oil is extracted from the traditional Chinese medicine composition of any one of the above embodiments;

[0125] The weight ratio of volatile oil to solvent is 1:10-30.

[0126] The preparation in this embodiment can be a dew, which can be dripped or sprayed into the nasal cavity, and can effectively relieve symptoms such as nasal congestion, runny nose, sneezing, and nasal itching caused by rhinitis.

[0127] Volatile oils are volatile substances in traditional Chinese medicine compositions, including peppermint oil, seabuckthorn fruit oil, seabuckthorn seed oil and other ingredients, as well as volatile substances extracted from fresh plants (such as Xanthium sibiricum, citronella, and Platycladus orientalis leaves).

[0128] The solvent includes purified water or an ethanol / water mixture, and may also include a cosolvent, such as Tween-80, ethanol, etc. For example, the weight ratio of volatile oil, cosolvent, and water may be 1:2-5:10-20. Exemplarily, the weight ratio of volatile oil, cosolvent, and water may be 1:2:10, 1:3:15, or 1:5:20.

[0129] The volatile oil, cosolvent and water can be prepared by the following method: adding the cosolvent to the volatile oil, stirring evenly until emulsified, and then slowly adding purified water and stirring until completely dispersed.

[0130] To improve the stability of the lotion, citric acid or sodium bicarbonate may be added to the lotion to control the pH value of the lotion between 5.0 and 7.0. To improve the efficacy and shelf life of the lotion, appropriate amounts of preservatives (such as sodium benzoate and potassium sorbate) and antioxidants (such as vitamin E and BHT) may be added to the lotion.

[0131] The prepared lotion is filtered through a 0.45μm microporous membrane to remove tiny particles and ensure clarity. The lotion is then bottled at 60-70°C or room temperature.

[0132] The volatile oil can be obtained by washing and drying the Chinese medicine composition, crushing it into 20-40 meshes, and obtaining pre-treated pellets; then crudely extracting the pellets by steam distillation or solvent extraction to obtain crude oil; and then separating and purifying the crude oil.

[0133] For example, steam distillation involves the following steps:

[0134] Feeding and distillation: Add the pellets into the distillation flask, add 5-10 times the mass of the pellets of purified water, so that the purified water completely immerses the pellets; then heat to boiling to allow the volatile components to evaporate with the water vapor.

[0135] Condensation and separation: The steam mixture is condensed into liquid form through a condenser and then enters the oil-water separator. Since the density of volatile oil is lower than that of water, the two will separate into layers; the upper layer is volatile oil and the lower layer is distilled water. The volatile oil is separated by the separator to obtain crude oil.

[0136] The solvent extraction method includes the following steps:

[0137] Solvent selection: Commonly used organic solvents such as ethanol and petroleum ether (must meet pharmaceutical or food grade standards).

[0138] Extraction process: Mix the pellets with the solvent in proportion, stir / soak at room temperature or low temperature (40-60℃) for several hours (to avoid high temperature destruction of components), and filter to obtain the extract.

[0139] Concentration: The extract is distilled under reduced pressure to recover the solvent and obtain concentrated crude oil (the temperature must be controlled below 60°C to prevent decomposition of components).

[0140] Crude oil extracted by steam distillation or solvent extraction may contain a small amount of impurities such as water, plant wax, pigment, etc., and requires further purification to improve its transparency and stability. The separation and purification method includes the following steps:

[0141] Water removal: Crude oil contains trace amounts of water (common in steam distillation). This can be removed by adding a desiccant such as anhydrous sodium sulfate or calcium chloride, allowing the oil to stand overnight, and filtering to remove the desiccant.

[0142] Alternatively, use a low-temperature freezing method (standing at -5 to -10°C for 24 hours) to freeze the water and then filter and separate it.

[0143] Impurity removal: The wax is precipitated by low-temperature refrigeration (5-10°C), filtered to remove the wax, and then further purified by activated carbon adsorption or molecular distillation (the temperature needs to be controlled within 80°C to avoid component loss) to obtain volatile oil.

[0144] In order to more clearly explain the technical solution of the present application, the present application lists specific examples of Chinese medicine compositions for treating rhinitis.

[0145] Example

[0146] Example 1: A Chinese medicine composition for treating rhinitis, comprising the following components by weight:

[0147] Xanthium sibiricum 5g; Cymbopogon citratus 5g; Platycladus orientalis leaf 3g; Sweet almond 3g; Mulberry leaf 4g; Tianshan ice chrysanthemum 5g; Wild chrysanthemum 5g; Apocynum venetum leaf 5g; Ili Fritillaria 4g; Sea buckthorn fruit oil 2g.

[0148] In order to more clearly explain the technical solution of the present application, the present application also lists Examples 2-10 of the Chinese medicine composition, wherein the formulas of Examples 2-10 are shown in Table 1.

[0149] Table 1 shows specific examples of the Chinese medicine composition of the present application. It should be noted that, except for the parameters listed in Table 1, other parameters of Examples 2-10 are substantially the same as those of Example 1.

[0150] Table 1: Formula of the Chinese medicine composition of the embodiment (unit: g)

[0151]

[0152]

[0153] Note: “ / ” in Table 1 means that the formula does not contain this component.

[0154] Application Examples

[0155] The Chinese medicine composition in the examples was prepared into honey pills and lotion according to the following methods.

[0156] Honey pills: The Chinese medicinal composition is dried at 60°C, crushed, and sieved to obtain a 100-mesh powder. The powder is then mixed with refined honey in a weight ratio of 1:1.0 to obtain a mixture. The mixture is pressed into cakes, formed into strips, cut into segments, and rolled into balls to obtain honey pills.

[0157] Dew: Dry the traditional Chinese medicine composition at 60°C, crush, and sieve to obtain a 40-mesh powder. Mix the powder with purified water in a 1:10 weight ratio and heat to boiling, allowing volatile substances to evaporate along with the water vapor to produce a mixed vapor. Condensate the mixed vapor, allow it to stand for stratification, and extract the upper oil layer to obtain a crude oil. Separate and purify the crude oil to obtain a volatile oil. Add twice the weight of Tween-80 to the volatile oil, stir and emulsify, then add 10 times the weight of purified water to the volatile oil. After stirring, add a pH adjuster to adjust the pH to 6.5 to obtain a dew.

[0158] Among them, Application Examples 1-10 correspond to honey pills prepared from the Chinese medicine compositions of Examples 1-10 respectively; Application Example 11 is the simultaneous oral administration of honey pills prepared from the Chinese medicine composition of Example 2 and the external use of the Chinese medicine composition prepared from Example 2; Application Example 12 is the simultaneous oral administration of honey pills prepared from the Chinese medicine composition of Example 6 and the external use of the Chinese medicine composition prepared from Example 6; Application Example 13 is the simultaneous oral administration of honey pills prepared from the Chinese medicine composition of Example 9 and the external use of the Chinese medicine composition prepared from Example 9.

[0159] Drug effects

[0160] The therapeutic effects of the honey pills or lotions of the application examples on rhinitis symptoms were evaluated according to the following method, and the statistical results are recorded in Table 2.

[0161] 1. Total Nasal Symptom Score (TNSS): The TNSS includes scores for the following nasal symptoms: nasal congestion, sneezing, nasal itching, and runny nose. Each symptom is scored on a scale of 0 to 3: 0: no symptoms; 1: mild symptoms, easily tolerated; 2: significant symptoms, but still tolerable; 3: severe symptoms, difficult to tolerate, and affecting daily life. The total TNSS score ranges from 0 to 12, with higher scores indicating more severe symptoms.

[0162] 2. Reflective Total Nasal Symptom Score (rTNSS): The rTNSS is a scale used to assess the severity of rhinitis symptoms. It quantifies symptom severity by retrospectively assessing nasal symptoms over the past period (usually the past 12 hours). The rTNSS includes scores for the following nasal symptoms: nasal congestion, sneezing, nasal itching, and runny nose. Each symptom is scored on a scale of 0 to 3: 0: no symptoms; 1: mild symptoms, easily tolerated; 2: significant symptoms, but still tolerable; 3: severe symptoms, difficult to tolerate, and affecting daily life. The total rTNSS score ranges from 0 to 12, with higher scores indicating more severe symptoms.

[0163] 3. Reflective Total Ocular Symptom Score (rTOSS): rTOSS is a scale used to assess the severity of rhinitis symptoms. It quantifies the severity of symptoms through patients' retrospective assessment of ocular symptoms over the past period of time (usually the past 12 hours). rTOSS includes scores for the following ocular symptoms: Eye Itching / Burning; Eye Tearing / Watering; Eye Redness. The score range for each symptom is 0 to 3 points: 0 points: no symptoms; 1 point: mild symptoms, easily tolerated; 2 points: obvious symptoms, but still tolerable; 3 points: severe symptoms, difficult to tolerate, affecting daily life. The total score of rTOSS ranges from 0 to 12 points, with higher scores indicating more severe symptoms.

[0164] 650 patients with moderate to severe allergic rhinitis (AR) were treated with the honey pills or honey pill / dew of Application Examples 1-13, with 50 patients in each group.

[0165] The treatment plan is: for the acute group (acute rhinitis), take the honey pills orally and the lotion for external use twice a day; for the chronic group (chronic rhinitis), take the medicine every other day, twice a day, and only take the honey pills orally.

[0166] After treatment, the changes in rTNSS, rTOSS, TNSS, effective rate and markedly effective rate were statistically analyzed, and the recurrence rate after one year of treatment was also statistically analyzed.

[0167] Among them, significant efficacy = (number of significant efficacy cases / total number of treated cases) × 100%;

[0168] Effective rate = (number of markedly effective cases + number of effective cases) / total number of treated cases × 100%.

[0169] Table 2 Evaluation effect of the preparation for treating rhinitis in the application example

[0170]

[0171] Note: “-” in Table 2 indicates a decrease in the score after treatment compared with the score before treatment.

[0172] As can be seen from Tables 1 and 2, the honey pills or lotions prepared using the traditional Chinese medicine compositions of the embodiments of the present application have a good therapeutic effect on rhinitis in patients with rhinitis and can significantly improve the symptoms of rhinitis. In addition, the combined use of oral honey pills and topical lotions can effectively improve the therapeutic effect, improve symptoms, and shorten the course of the disease.

[0173] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A Chinese medicine composition for treating rhinitis, characterized in that: The Chinese medicine composition comprises the following components in parts by weight: 5-20 parts by weight of Xanthium sibiricum fruit; 5-20 parts by weight of citronella; 3-15 parts by weight of Platycladus orientalis leaves; 3-15 parts by weight of sweet almonds; 4-18 parts by weight of mulberry leaves; 5-20 parts by weight of Tianshan Ice Chrysanthemum; 5-20 parts by weight of wild chrysanthemum; 5-20 parts by weight of Apocynum venetum leaves; 4-18 parts by weight of Fritillaria yiliensis; 2-10 parts by weight of sea buckthorn fruit oil.

2. The Chinese medicine composition for treating rhinitis according to claim 1, characterized in that The Chinese medicine composition further comprises the following components in parts by weight: 2-10 parts by weight of peppermint oil; 5-20 parts by weight of Angelica dahurica; 4-18 parts by weight of melon vine; 3-15 parts by weight of Fritillaria wuqia; 8-20 parts by weight of Gobi parsnip; 5-20 parts by weight of magnolia flower.

3. The Chinese medicine composition for treating rhinitis according to claim 1 or 2, characterized in that The Chinese medicine composition further comprises the following components in parts by weight: 4-18 parts by weight of Rhodiola rosea; 3-15 parts by weight of snow lotus heart.

4. The Chinese medicine composition for treating rhinitis according to claim 1, characterized in that The Chinese medicine composition further comprises: 5-10 parts by weight of honey; and / or, The Chinese medicine composition further comprises: 6-12 parts by weight of liquorice.

5. A preparation for treating rhinitis, characterized in that: The preparation comprises the Chinese medicine composition according to any one of claims 1 to 4 and excipients; The weight ratio of the traditional Chinese medicine composition to the auxiliary material is 1:1.0-1.

5.

6. The preparation for treating rhinitis according to claim 5, characterized in that The auxiliary material includes refined honey.

7. The preparation for treating rhinitis according to claim 6, characterized in that The preparation further comprises a lubricant, and the weight of the lubricant is 5.0-10.0% of the weight of the traditional Chinese medicine composition.

8. The preparation for treating rhinitis according to claim 5, characterized in that The water content of the preparation is less than or equal to 18%.

9. A method for preparing a preparation for treating rhinitis, characterized in that: The preparation method is used to prepare the preparation according to any one of claims 5 to 8, and the preparation method comprises: Drying, crushing, and sieving the traditional Chinese medicine composition to obtain a powder with a fineness of 80-200 mesh; The medicinal powder is mixed with the auxiliary materials to prepare the preparation.

10. A preparation for treating rhinitis, characterized in that: The preparation comprises volatile oil and a solvent, wherein the volatile oil is extracted from the traditional Chinese medicine composition according to any one of claims 1 to 4; The weight ratio of the volatile oil to the solvent is 1:10-30.

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