22 results about "Bacterial vaginitis" patented technology

The invention relates to the field of biotechnology and female health care, in particular to a stachyose composition for promoting micro-ecological regulation of lactobacillus and application of the stachyose composition, and the composition comprises stachyose and pharmaceutically acceptable auxiliary materials. The stachyose is used as prebiotics to selectively promote proliferation and colonization of the lactobacillus crispatus, the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can promote proliferation of the lactobacillus crispatus, the lactobacillus crispatus is one or more of the lactobacillus crispatus, the lactobacillus plantarum and the lactobacillus acidophilus, and the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can inhibit gardnerella and candida albicans. The stachyose composition disclosed by the invention is in the form of slow-release gel and bath foam; the composition can be used for treating or preventing bacterial vaginitis, colpitis mycotica and related symptoms, has the advantages of no antibiotics, no drug resistance, high safety and the like, and is suitable for the fields of vagina local nursing and micro-ecological regulation.

The invention relates to the field of pharmacy, and discloses a Chinese herbal medicine and marine extract combined antibacterial and anti-inflammatory pharmaceutical composition which comprises the following components in parts by weight: 5-10 parts of baicalin extract; 3 to 7 parts of an andrographolide extract; 2-5 parts of sulfated brown algae polysaccharide; 0.2 to 1 part of sponge extract; wherein the baicalin extract is derived from roots of scutellaria baicalensis and is obtained by extracting with an ethanol-water mixed solvent; the andrographolide extract is derived from the whole herb of andrographis paniculata and is obtained by extracting with an ethanol-water mixed solvent; the sulfated fucoidan is derived from fucoidan and is prepared by enzymolysis and alcohol precipitation methods; the sponge extract is derived from sponge and is obtained by organic solvent extraction, separation and purification. By adopting the technical scheme of synergistically compounding the Chinese herbal medicine active ingredients and the marine extract, the technical effects of destroying a biological membrane barrier and removing stubborn infection lesions in treatment of bacterial vaginitis, candida vaginitis associated biological membrane infection and cervicitis are achieved.

The present application relates to the field of pharmacy, disclose the medicine composition for antibacterial and anti-inflammatory of Chinese herbal medicine and marine extract combination, including: baicalin extract 5~10 parts; andrographolide extract 3~7 parts; sulfated fucoidan 2~5 parts; spongin extract 0.2~1 part; wherein: baicalin extract is derived from the root of scrophulariaceae, is extracted by ethanol-water mixed solvent; andrographolide extract is derived from the whole plant of andrographis, is extracted by ethanol-water mixed solvent; sulfated fucoidan is derived from brown algae, is prepared by enzymolysis and alcohol precipitation method; spongin extract is derived from sponges, is extracted and separated and purified by organic solvent. Through the technical scheme of the synergistic combination of active ingredients of Chinese herbal medicine and marine extract, the technical effect of destroying the biofilm barrier and clearing the stubborn infection focus in the treatment of bacterial vaginitis, candida vaginitis and cervical inflammation associated with biofilm infection is achieved.

The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.

The present invention relates to a composition, which contains lactobacillus and lactobacillus, wherein the number of viable lactobacillus in the composition is not less than 1×10 6 CFU, the composition contains 1×10 6 ~1×10 10 The composition of the present invention can be used to treat and / or prevent vaginal infections such as bacterial vaginosis and aerobic bacterial vaginitis, and can be used in the pharmaceutical field.

The invention belongs to the technical field of medical gel, and particularly relates to gynecological antibacterial gel and a preparation method thereof. The gel comprises an antibacterial phase and a bacterium promoting phase, and broad-spectrum inhibition of common pathogenic bacteria is achieved through the synergistic proportion of naringin, nisin and ethyl lauroyl arginate hydrochloride; meanwhile, a lactobacillus rhamnosus metabolite, sodium hyaluronate and the like are introduced to construct a bacterium promoting phase, and probiotic colonization and vagina micro-ecological balance reconstruction are promoted. The pH value of the gel is stabilized at 4.0-4.5, and the gel has good rheological properties and retention performance. In the preparation method, all the components are added step by step, the system temperature and stirring conditions are controlled, and the component activity and the product stability are guaranteed. The traditional Chinese medicine composition can effectively relieve bacterial vaginitis, fungal infection and micro-ecological disorder, and has a synergistic, safe and mild comprehensive nursing effect.

The invention relates to the technical field of gene detection, in particular to a primer group and application thereof, and a training method of a bacterial vaginitis diagnosis model. The primer group is used for diagnosing bacterial vaginitis and comprises a specific primer, and the target areas are used for specifically amplifying the following target pathogens: Atortobacterium vaginalis, Gardneria vaginalis, type 1 giant coccus, type 2 giant coccus, bacterial vaginitis related bacteria 2, campylobacter kirschengensis, campylobacter pudicus, two-way prevotella, Lactobacillus crispatus, Lactobacillus inervis, Lactobacillus gasseri and Lactobacillus jensenii. The invention also provides application of the primer group and a training method of a bacterial vaginitis diagnosis model. The primer group can be used for carrying out high-throughput sequencing on a to-be-detected sample, 12 target pathogens can be detected at the same time, a bacterial vaginitis diagnosis model is further constructed, and the primer group can be used for clinical diagnosis of bacterial vaginitis and has good specificity and sensitivity.

The application discloses a traditional Chinese medicine composition for treating vaginitis and a preparation method thereof. The traditional Chinese medicine composition mainly comprises 12 Chinese herbal medicines, i.e. Sophora flavescens, Phellodendron chinense, Dictamnus dasycarpus, Herba Artemisiae Scopariae, Herba Taraxaci, Chrysanthemum indicum, Herba Portulacae, Cnidium monnieri, Angelica polymorpha, Herba Verbena, Herba Menthae and Saposhnikovia divaricata, and further comprises Salix viminalis, Eucalyptus, Ephedra sinica, anthocyanin quaternary ammonium salt, Ocimum basilicum, Houttuynia cordata, polysialic acid, polydopamine, antibacterial polypeptide modified chitosan hydrochloride and artemether. The traditional Chinese medicine composition is prepared by mixing traditional Chinese medicines and bactericidal and bacteriostatic biocompatible materials to prepare various medicaments. The traditional Chinese medicine composition is used for treating pruritus and leukorrhagia caused by endogenous insect poison and burning of yin fluid, and is used for treating bacterial vaginitis, mycotic vaginitis, trichomonal vaginitis and vulvitis. In clinical tests, the traditional Chinese medicine composition has remarkable treatment effect, and the cure rate is more than 95%.

The invention provides bacteriostatic gel for women and a preparation method thereof, and belongs to the technical field of gynecological gel. The gel comprises 97%-99% of a multi-layer structure base material and 1%-3% of a natural plant effective component. The effective components comprise seven natural components such as a fructus cnidii extract, a helichthys italica extract and a radix sophorae flavescentis extract, and the base material comprises multiple layers of hydrogel. In the use process of the bacteriostatic gel for women, the fructus cnidii extract and the radix sophorae flavescentis extract can directly kill pathogenic bacteria of bacterial vaginitis and have an inhibition effect on HPV viruses, and the tea leaf extract and the psidium guajava leaf extract have antioxidant and bacteriostatic characteristics, so that the capacity of removing harmful microorganisms can be further enhanced. And the base material comprising multiple layers of hydrogel not only can enable bacteriostatic and anti-inflammatory components to continuously act on a focus part and improve the treatment effect on vaginitis and vulvitis, but also can reduce direct stimulation of subsequent effective components on sensitive mucous membranes, and is especially suitable for mucous membrane fragile scenes such as gynecologic operations and acute inflammation stages.

To provide an inhibitor of bacterial vaginosis.SOLUTION: An inhibitor of bacterial vaginosis comprises lactic acid and / or a salt thereof.SELECTED DRAWING: None

The invention provides a novel application of an antibacterial peptide Ly (PEG)-1 reported at an earlier stage in vaginitis, belongs to the technical field of biomedical polypeptides, and particularly relates to preparation of the antibacterial peptide Ly (PEG)-1, an effect of the antibacterial peptide Ly (PEG)-1 on main vaginal pathogenic bacteria and symbiotic bacteria and an application of the antibacterial peptide Ly (PEG)-1 in prevention or treatment of bacterial vaginitis. The antibacterial peptide Ly (PEG)-1 provided by the invention is short in sequence, low in production cost, capable of strongly inhibiting main pathogenic bacteria of vagina, small in influence on main normal bacteria of the main pathogenic bacteria, capable of effectively treating vagina inflammation and maintaining the steady state of vaginal flora, high in stability and good in antibacterial effect. Vagina inflammatory diseases caused by infection of various pathogenic bacteria can be prevented and treated through various administration modes such as spraying, instillation, suppositories and effervescent tablets or systemic administration modes such as intraperitoneal injection and the like.

The application discloses a vaginal probiotic composition for relieving multiple vaginitis, and belongs to the technical field of microorganisms. The combination of Lactobacillus crispatus CCFM1298, Lactobacillus gasseri CCFM1201 and fructooligosaccharide is selected based on the growth characteristics of the strains, the synergistic symbiosis of the combined strains is realized, and the effect of multiple relief of vaginitis is realized. The probiotic composition can relieve vaginal tissue inflammation, regulate the local immune system of the vagina, and help relieve and improve bacterial vaginitis and candidal vaginitis of women. Moreover, since the probiotics are all derived from the vagina of healthy women, the probiotics are used in the preparation of products and sanitary products for female vaginitis, help relieve and improve female vaginitis, and have a good application prospect.

A controlled release, antimicrobial gel for the treatment of vaginal infections, comprises a muco-adhesive gel matrix containing one or more anti-infective agents bound to said matrix and effective for the treatment of vaginal infections and capable of pH dependent delivery of said one or more anti-infective agents as a single application to the vaginal cavity over a period of 3 days, while the muco-adhesive gel matrix remains bound to the vaginal epithelia. The preferred anti-infective agents are thymol and carvacrol in combination. The antimicrobial gel is biocidal against biofilms formed by the causative agents of bacterial vaginosis, trichomoniasis and candidiasis. The antimicrobial gel is effective for achieving sustained delivery of the anti-infective agents to the vaginal cavity at a therapeutically efficacious dose from a single application of the gel for the treatment and prevention, and prevention of recurrence, of bacterial vaginosis, trichomoniasis and candidiasis.

The traditional Chinese medicine gel vaginal plug is prepared from the following raw materials in parts by weight: 6-8 parts of channel-warming and cold-dispelling traditional Chinese medicines, 4-5 parts of fresh ginger, 3-4 parts of cinnamon, 2-3 parts of fructus evodiae and 3-4 parts of rhizoma cyperi. 6-7 parts of antibacterial and anti-inflammatory traditional Chinese medicines, 6-7 parts of radix sophorae flavescentis and 6-7 parts of fructus cnidii; 4-5 parts of salvia miltiorrhiza and 3-4 parts of safflower carthamus; the gel matrix comprises the following components in parts by weight: 1.7 to 1.9 parts of carbomer 940, 0.7 to 0.9 part of chitosan and 0.4 to 0.5 part of sodium hyaluronate; the auxiliary materials comprise 0.15 to 0.18 part of azone serving as a transdermal enhancer and 0.07 to 0.09 part of phenoxyethanol serving as a preservative. Through vaginal administration, the uterine cavity environment can be improved, the temperature of the body and the small intestine can be increased in cooperation with online body temperature regulation guidance, gynecological problems such as mycotic and bacterial vaginitis, cervical erosion, polyp, HPV infection, cyst and myoma can be improved in an auxiliary mode, cyst and myoma improvement is relatively slow, use is convenient, and safety is high.

The invention provides a probiotic composition containing lactobacillus gasseri LN32 and lactobacillus crispatus LN70 and application of the probiotic composition to reduction of vaginal infection risk, and belongs to the technical field of microorganism application. The probiotic feed additive contains four strains of probiotics, including plant lactobacillus LN66, lactobacillus rhamnosus LN56, lactobacillus gasseri LN32 and lactobacillus crispatus LN70. The probiotic composition realizes vaginal flora reconstruction through oral administration, inhibits reproduction of Gardneria vaginalis and Candida albicans, increases lactobacillus colonization, and eliminates abnormal leucorrhea, vaginal scorching heat and itching, frequent urination, urgent urination, dysuria and the like. The probiotic composition is combined with a conventional carrier, and is applied to preparation of food, dietary supplement or medicine for preventing and / or treating microecological imbalance of vagina and urethra, bacterial vaginitis, colpitis mycotica and urethral infection. Therefore, vaginal harmful bacteria are inhibited, vaginal flora is reconstructed, and the vaginal infection risk and the urethral infection risk are reduced.

The present application provides a kind of lactobacillus gasseri LN32 and lactobacillus crispatus LN70 containing probiotic composition and application in reducing the risk of vaginal infection, belong to microbial application technical field.Containing 4 strains of probiotics, including lactobacillus plantarum LN66, lactobacillus rhamnosus LN56, lactobacillus gasseri LN32 and lactobacillus crispatus LN70.The probiotic composition is realized by oral route, vaginal flora reconstruction, inhibit the reproduction of gardnerella vaginalis and candida albicans, increase lactobacillus colonization, eliminate abnormal leucorrhea, vaginal burning and itching, frequent urination, urgency and pain.The probiotic composition is combined with conventional carrier, applied to prepare food, dietary supplement or drug for preventing and / or treating vaginal and urethral microecological disorder, bacterial vaginitis, mycotic vaginitis and urethral infection, and then the present application realizes inhibiting harmful bacteria in vagina, reconstructing vaginal flora to reduce the risk of vaginal infection and reduce the risk of urethral infection.

To provide a composition and method for detecting bacterial nucleic acids and diagnosing bacterial vaginosis. [Solution] A method for diagnosing a target bacterial vaginosis is disclosed, comprising performing an assay to detect one or more of the following species in a target sample: Lactobacillus, Atopobium vaginae, and Gardneralla vaginalis. Also disclosed are compositions and methods for detecting the nucleic acids of Lactobacillus, Atopobium vaginae, and / or Gardneralla vaginalis in a sample.

The invention discloses lactobacillus crispatus, a microbial inoculum and a preparation method and application of the lactobacillus crispatus and the microbial inoculum. The lactobacillus crispatus disclosed by the invention is lactobacillus crispatus OH126 of which the preservation number is GDMCC (China General Microbiological Culture Collection Center) No.66536. The lactobacillus crispatus newly researched and developed in the invention can effectively inhibit growth of common vaginal pathogenic bacteria, is adaptive to a vaginal micro-ecological environment, has good vaginal mucosa colonization ability, and can also assist in improving related symptoms of hysteromyoma. Meanwhile, vaginal freeze-dried tablets, vaginal gel and other microbial agents can be prepared, and the activity and storage stability of thalli are ensured by optimizing the preparation process. The strain and the microbial inoculum can be used for adjusting female vagina micro-ecological balance, treating or preventing bacterial vaginitis and assisting in improving related symptoms of hysteromyoma, and a new scheme and a new way are provided for prevention and treatment of female reproductive system diseases such as bacterial vaginitis and hysteromyoma.

The present application relates to the functional microorganism screening and application technical field, specifically provide a lactobacillus gasseri with the efficacy of preventing and treating female vaginitis and application thereof.The lactobacillus gasseri is preserved in CCTCC NO: M2023609, can produce bacteriostatic substance H2O2, and can inhibit the growth of vagina gardner and candida albicans under the condition of mixed culture, and the inhibition rates are 97% and 100% respectively, and can be applied to the prevention and adjuvant therapy of female bacterial vaginitis and mycotic vaginitis.

The invention discloses an application of pulsatilla saponin B5 with a structure shown as a formula I in preparation of a medicine for vaginitis and / or cervicitis. The vaginitis is bacterial vaginitis, and the cervicitis is bacterial inflammation of the cervix and the vagina. The invention relates to a spray for vaginitis and / or cervicitis, in particular to bacterial vaginitis and / or bacterial cervix and vagina inflammation and application thereof. The spray is prepared from the following components in parts by weight: 0.5 to 5 parts of pulsatilla saponin B5, 0.05 to 1 part of sucralose, 0.01 to 0.05 part of benzalkonium chloride and 100 parts of water.

The invention discloses a traditional Chinese medicine gel composition for vaginal mucosa bacteriostasis and a preparation method thereof, and belongs to the technical field of biological medicine. The composition is prepared from extracts of nine traditional Chinese medicines including radix sophorae flavescentis, fructus cnidii, radix stemonae and the like and a carbomer-xanthan gum-hydroxyethyl cellulose ternary compound matrix through an ultrasonic-water decoction combined extraction process. The traditional Chinese medicine extracts synergistically achieve broad-spectrum bacteriostasis, the inhibition rates on staphylococcus aureus, escherichia coli and candida albicans are all larger than or equal to 90%, the ternary matrix film forming time is shorter than or equal to 3 minutes, continuous attachment in the vagina is longer than or equal to 8 hours, and the vaginal mucosa stimulation response score is smaller than or equal to 0.5. The gel solves the problems of limited antibacterial spectrum, slow film formation, short adhesion time and insufficient mucous membrane repair ability of the existing gel, is suitable for treatment of bacterial vaginitis and monilial vaginitis, and has the advantages of high efficiency, safety and high patient compliance.

The invention provides a female external nursing product with antibacterial, anti-inflammatory and antipruritic effects and a preparation method thereof, and relates to the technical field of biological medicine nursing products. The invention provides an external nursing product for women, which is prepared from the following pure traditional Chinese medicinal materials: cortex ailanthi, saururus chinensis, pericarpium granati, chingma abutilon seeds, red halloysite, lysimachia clethroides, gynura plicata, evodia lepta leaves, peach leaves, pine needles, water gossypium, solanum lyratum and cyrtomium fortunei as raw materials. The traditional Chinese medicine raw materials in the product are scientific in compatibility and have a synergistic effect, the product shows an ultra-excellent antibacterial effect on staphylococcus aureus, escherichia coli and candida albicans, meanwhile, the product has good anti-inflammatory and anti-inflammatory effects, can achieve rapid itching relieving, and in addition, the product has no stimulation effect on vaginal mucosa of female white rabbits and has good safety. The product disclosed by the invention can be used for effectively improving the symptoms such as itching and causalgia, peculiar smell and abnormal secretion caused by colpitis mycotica, bacterial vaginitis, trichomonas vaginitis, senile vaginitis and the like.