12 results about "Bacterial vaginitis" patented technology

The invention relates to the field of biotechnology and female health care, in particular to a stachyose composition for promoting micro-ecological regulation of lactobacillus and application of the stachyose composition, and the composition comprises stachyose and pharmaceutically acceptable auxiliary materials. The stachyose is used as prebiotics to selectively promote proliferation and colonization of the lactobacillus crispatus, the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can promote proliferation of the lactobacillus crispatus, the lactobacillus crispatus is one or more of the lactobacillus crispatus, the lactobacillus plantarum and the lactobacillus acidophilus, and the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can inhibit gardnerella and candida albicans. The stachyose composition disclosed by the invention is in the form of slow-release gel and bath foam; the composition can be used for treating or preventing bacterial vaginitis, colpitis mycotica and related symptoms, has the advantages of no antibiotics, no drug resistance, high safety and the like, and is suitable for the fields of vagina local nursing and micro-ecological regulation.

The present application relates to the field of pharmacy, disclose the medicine composition for antibacterial and anti-inflammatory of Chinese herbal medicine and marine extract combination, including: baicalin extract 5~10 parts; andrographolide extract 3~7 parts; sulfated fucoidan 2~5 parts; spongin extract 0.2~1 part; wherein: baicalin extract is derived from the root of scrophulariaceae, is extracted by ethanol-water mixed solvent; andrographolide extract is derived from the whole plant of andrographis, is extracted by ethanol-water mixed solvent; sulfated fucoidan is derived from brown algae, is prepared by enzymolysis and alcohol precipitation method; spongin extract is derived from sponges, is extracted and separated and purified by organic solvent. Through the technical scheme of the synergistic combination of active ingredients of Chinese herbal medicine and marine extract, the technical effect of destroying the biofilm barrier and clearing the stubborn infection focus in the treatment of bacterial vaginitis, candida vaginitis and cervical inflammation associated with biofilm infection is achieved.

The invention belongs to the technical field of medical gel, and particularly relates to gynecological antibacterial gel and a preparation method thereof. The gel comprises an antibacterial phase and a bacterium promoting phase, and broad-spectrum inhibition of common pathogenic bacteria is achieved through the synergistic proportion of naringin, nisin and ethyl lauroyl arginate hydrochloride; meanwhile, a lactobacillus rhamnosus metabolite, sodium hyaluronate and the like are introduced to construct a bacterium promoting phase, and probiotic colonization and vagina micro-ecological balance reconstruction are promoted. The pH value of the gel is stabilized at 4.0-4.5, and the gel has good rheological properties and retention performance. In the preparation method, all the components are added step by step, the system temperature and stirring conditions are controlled, and the component activity and the product stability are guaranteed. The traditional Chinese medicine composition can effectively relieve bacterial vaginitis, fungal infection and micro-ecological disorder, and has a synergistic, safe and mild comprehensive nursing effect.

The application discloses a traditional Chinese medicine composition for treating vaginitis and a preparation method thereof. The traditional Chinese medicine composition mainly comprises 12 Chinese herbal medicines, i.e. Sophora flavescens, Phellodendron chinense, Dictamnus dasycarpus, Herba Artemisiae Scopariae, Herba Taraxaci, Chrysanthemum indicum, Herba Portulacae, Cnidium monnieri, Angelica polymorpha, Herba Verbena, Herba Menthae and Saposhnikovia divaricata, and further comprises Salix viminalis, Eucalyptus, Ephedra sinica, anthocyanin quaternary ammonium salt, Ocimum basilicum, Houttuynia cordata, polysialic acid, polydopamine, antibacterial polypeptide modified chitosan hydrochloride and artemether. The traditional Chinese medicine composition is prepared by mixing traditional Chinese medicines and bactericidal and bacteriostatic biocompatible materials to prepare various medicaments. The traditional Chinese medicine composition is used for treating pruritus and leukorrhagia caused by endogenous insect poison and burning of yin fluid, and is used for treating bacterial vaginitis, mycotic vaginitis, trichomonal vaginitis and vulvitis. In clinical tests, the traditional Chinese medicine composition has remarkable treatment effect, and the cure rate is more than 95%.

The invention provides bacteriostatic gel for women and a preparation method thereof, and belongs to the technical field of gynecological gel. The gel comprises 97%-99% of a multi-layer structure base material and 1%-3% of a natural plant effective component. The effective components comprise seven natural components such as a fructus cnidii extract, a helichthys italica extract and a radix sophorae flavescentis extract, and the base material comprises multiple layers of hydrogel. In the use process of the bacteriostatic gel for women, the fructus cnidii extract and the radix sophorae flavescentis extract can directly kill pathogenic bacteria of bacterial vaginitis and have an inhibition effect on HPV viruses, and the tea leaf extract and the psidium guajava leaf extract have antioxidant and bacteriostatic characteristics, so that the capacity of removing harmful microorganisms can be further enhanced. And the base material comprising multiple layers of hydrogel not only can enable bacteriostatic and anti-inflammatory components to continuously act on a focus part and improve the treatment effect on vaginitis and vulvitis, but also can reduce direct stimulation of subsequent effective components on sensitive mucous membranes, and is especially suitable for mucous membrane fragile scenes such as gynecologic operations and acute inflammation stages.

The invention provides a novel application of an antibacterial peptide Ly (PEG)-1 reported at an earlier stage in vaginitis, belongs to the technical field of biomedical polypeptides, and particularly relates to preparation of the antibacterial peptide Ly (PEG)-1, an effect of the antibacterial peptide Ly (PEG)-1 on main vaginal pathogenic bacteria and symbiotic bacteria and an application of the antibacterial peptide Ly (PEG)-1 in prevention or treatment of bacterial vaginitis. The antibacterial peptide Ly (PEG)-1 provided by the invention is short in sequence, low in production cost, capable of strongly inhibiting main pathogenic bacteria of vagina, small in influence on main normal bacteria of the main pathogenic bacteria, capable of effectively treating vagina inflammation and maintaining the steady state of vaginal flora, high in stability and good in antibacterial effect. Vagina inflammatory diseases caused by infection of various pathogenic bacteria can be prevented and treated through various administration modes such as spraying, instillation, suppositories and effervescent tablets or systemic administration modes such as intraperitoneal injection and the like.

The application discloses a vaginal probiotic composition for relieving multiple vaginitis, and belongs to the technical field of microorganisms. The combination of Lactobacillus crispatus CCFM1298, Lactobacillus gasseri CCFM1201 and fructooligosaccharide is selected based on the growth characteristics of the strains, the synergistic symbiosis of the combined strains is realized, and the effect of multiple relief of vaginitis is realized. The probiotic composition can relieve vaginal tissue inflammation, regulate the local immune system of the vagina, and help relieve and improve bacterial vaginitis and candidal vaginitis of women. Moreover, since the probiotics are all derived from the vagina of healthy women, the probiotics are used in the preparation of products and sanitary products for female vaginitis, help relieve and improve female vaginitis, and have a good application prospect.

The present application provides a kind of lactobacillus gasseri LN32 and lactobacillus crispatus LN70 containing probiotic composition and application in reducing the risk of vaginal infection, belong to microbial application technical field.Containing 4 strains of probiotics, including lactobacillus plantarum LN66, lactobacillus rhamnosus LN56, lactobacillus gasseri LN32 and lactobacillus crispatus LN70.The probiotic composition is realized by oral route, vaginal flora reconstruction, inhibit the reproduction of gardnerella vaginalis and candida albicans, increase lactobacillus colonization, eliminate abnormal leucorrhea, vaginal burning and itching, frequent urination, urgency and pain.The probiotic composition is combined with conventional carrier, applied to prepare food, dietary supplement or drug for preventing and / or treating vaginal and urethral microecological disorder, bacterial vaginitis, mycotic vaginitis and urethral infection, and then the present application realizes inhibiting harmful bacteria in vagina, reconstructing vaginal flora to reduce the risk of vaginal infection and reduce the risk of urethral infection.

To provide a composition and method for detecting bacterial nucleic acids and diagnosing bacterial vaginosis. [Solution] A method for diagnosing a target bacterial vaginosis is disclosed, comprising performing an assay to detect one or more of the following species in a target sample: Lactobacillus, Atopobium vaginae, and Gardneralla vaginalis. Also disclosed are compositions and methods for detecting the nucleic acids of Lactobacillus, Atopobium vaginae, and / or Gardneralla vaginalis in a sample.

The invention discloses lactobacillus crispatus, a microbial inoculum and a preparation method and application of the lactobacillus crispatus and the microbial inoculum. The lactobacillus crispatus disclosed by the invention is lactobacillus crispatus OH126 of which the preservation number is GDMCC (China General Microbiological Culture Collection Center) No.66536. The lactobacillus crispatus newly researched and developed in the invention can effectively inhibit growth of common vaginal pathogenic bacteria, is adaptive to a vaginal micro-ecological environment, has good vaginal mucosa colonization ability, and can also assist in improving related symptoms of hysteromyoma. Meanwhile, vaginal freeze-dried tablets, vaginal gel and other microbial agents can be prepared, and the activity and storage stability of thalli are ensured by optimizing the preparation process. The strain and the microbial inoculum can be used for adjusting female vagina micro-ecological balance, treating or preventing bacterial vaginitis and assisting in improving related symptoms of hysteromyoma, and a new scheme and a new way are provided for prevention and treatment of female reproductive system diseases such as bacterial vaginitis and hysteromyoma.

The present application relates to the functional microorganism screening and application technical field, specifically provide a lactobacillus gasseri with the efficacy of preventing and treating female vaginitis and application thereof.The lactobacillus gasseri is preserved in CCTCC NO: M2023609, can produce bacteriostatic substance H2O2, and can inhibit the growth of vagina gardner and candida albicans under the condition of mixed culture, and the inhibition rates are 97% and 100% respectively, and can be applied to the prevention and adjuvant therapy of female bacterial vaginitis and mycotic vaginitis.

The invention provides a female external nursing product with antibacterial, anti-inflammatory and antipruritic effects and a preparation method thereof, and relates to the technical field of biological medicine nursing products. The invention provides an external nursing product for women, which is prepared from the following pure traditional Chinese medicinal materials: cortex ailanthi, saururus chinensis, pericarpium granati, chingma abutilon seeds, red halloysite, lysimachia clethroides, gynura plicata, evodia lepta leaves, peach leaves, pine needles, water gossypium, solanum lyratum and cyrtomium fortunei as raw materials. The traditional Chinese medicine raw materials in the product are scientific in compatibility and have a synergistic effect, the product shows an ultra-excellent antibacterial effect on staphylococcus aureus, escherichia coli and candida albicans, meanwhile, the product has good anti-inflammatory and anti-inflammatory effects, can achieve rapid itching relieving, and in addition, the product has no stimulation effect on vaginal mucosa of female white rabbits and has good safety. The product disclosed by the invention can be used for effectively improving the symptoms such as itching and causalgia, peculiar smell and abnormal secretion caused by colpitis mycotica, bacterial vaginitis, trichomonas vaginitis, senile vaginitis and the like.