1708results about How to "No obvious side effects" patented technology

The invention relates to a traditional Chinese medicine composition for treating burn, comprising an oral medicine and an externally applied medicine, wherein the oral medicine is prepared from angelica sinensis, hemlock parsley, astragali, pseudo-ginseng, sanguisorba, safflower, radix rehmanniae, spatholobus stem, baikal skullcap root, giant knotweed, oldenlandia diffusa, dangshen, tuckahoe, white atractylodes rhizome and red peony root; and the externally applied medicine is prepared from myrrh, mastic, rhubarb, pseudo-ginseng, safflower, draconis sanguis, natural indigo, gromwell, fried sanguisorba, giant knotweed, carpet bugle, borneol and phellodendron bark. The traditional Chinese medicine composition provided by the invention is convenient to use and coat on an affected part for skin absorption, is easy to wash off and convenient to change dressing, can keep the surface of a wound wet, can prevent bacterial invasion, is capable of quickly alleviating pain, diminishing inflammation and relieving itching, and can promote the surface of a wound to heal quickly and reduce scar. In addition, the traditional Chinese medicine composition has short period of treatment, an obvious curative effect and no obvious toxic or side effect, has obvious efficacies of antibiosis, alleviating pain, subduing swelling, diminishing inflammation, adsorbing, converging, removing necrosis and promoting granulation, and is used through oral administration and external application with quite good effect.

The invention provides an application of a type of berbamine derivatives and salts thereof in the preparation of drugs for the treatment of tumors, which is mainly applied in the preparation of the drugs for the prevention and treatment of nuclear transcription factor NF-kBp65 activity-related diseases and BCR/ABL transcription activity-related diseases. The drugs are combined and prepared by the compounds of the invention and one or more pharmaceutically acceptable excipients. The preparation forms comprise solid preparations, semi-solid preparations or liquid preparations. The type of berbamine derivatives and the salts thereof provided by the invention have broader and stronger anti-leukemia and anti-solid-tumor activity, the tumors proved to be sensitive are leukemia, multiple myeloma, liver cancer, osteosarcoma and breast cancer; the toxicity and the side effects are lighter. An in vitro cell culture system and animal experiments confirm that the berbamine derivatives and the salts thereof have no significant toxicity or side effects to the growth of normal human hematopoietic cells and experimental animals under the anti-tumor dosage, which are superior to the commonly used chemotherapy drugs.

The invention discloses special dietary seafood special for hyperuricemia patients. The seafood is characterized by being prepared by taking food-derived marine bioactive polysaccharides as main raw materials, adding algae powder and mixing the food-derived marine bioactive polysaccharides and the algae powder with the auxiliary materials including nutritional amino acids, oligosaccharides, vitamins and minerals. The seafood can be powdery or granular and is eaten after being dissolved in warm water. The seafood is easy to dissolve, has maximum biological absorbance and maximum bioavailability in human bodies, provides marine active factors and nutritional components for human bodies, supplements various vitamins and minerals essential to human bodies, is beneficial to improving the nutritional status of the hyperuricemia patients and can assist in reducing the uric acid level and controlling the hyperuricemia level, improving the immune of the human bodies and preventing gout throughsynergy of such factors as bioactive components in the food-derived marine bioactive polysaccharides, the algae powder, the nutritional amino acids and the like, thus being suitable for the hyperuricemia patients.

The invention discloses a Chinese medicinal composition for treating arthritis, osteoproliferation and disc protrusion, which comprises the following raw material constituents (by weight ratio): large-leaf gentian root, ledebouriella root, Ligusticum wallichii, Clematis chinensis, achyranthes and cyathula root, root of herbaceous peony, prepared rehmannia root, Chinese angelica root, eucommia bark, Cinnamomum cassia, wolferry fruit, morinda root, dipsacus root, poria cocos, Chinese ephedra, Loranthus mulberry mistletoe, cassia twig, corydalis tuber, notoginseng, notopterygium root, root of red rooted saliva, tetrandra root, spatholobus stem, dried orange peel, licorice root, pangolin scales, buthus martensi karsch, earthworm, wood louse, dragon's blood resin, wasp's nest and drynaria.

The invention discloses an anti-tumor traditional Chinese medicine comprising medicinal materials such as astragalus mongholicus, American ginseng, angelica sinensis, sculellaria barbata, oldenlandia diffusa, bighead atractylodes rhizome, endothelium corneum gigeriae galli, grifola, paris polyphylla, Indian strawberry, radix ranunculi ternati, radix curcumae, honey-fried licorice root, scorpion, venenum bufonis and the like. All the medicines supplement each other so that the absorption and operation of the medicines are accelerated and all the medicines are prevented from being cool; and the anti-tumor traditional Chinese medicine has the effects of tonifying Qi of spleens and lungs, tonifying the spleen and promoting dampness, dissolving phlegm, softening hard mass, breaking Qi, clearing away heat and toxic materials, and promoting blood circulation and stopping pain; with regard to patients with a peed tumor and better physique, pseudo-ginseng, leech, the venenum bufonis and the whole scorpion can be added into the medicine to realize the aims of combating poison with poison and enhancing the effect, so as to realize the anti-cancer aim; and the anti-tumor traditional Chinese medicine continually has a better treating effect on the treatment of the tumor.

The invention relates to the field of genetic engineering, and in particular relates to an anti-EGFR ((Epidermal Growth Factor Receptor) chimeric antigen receptor, and a lymphocyte for expressing the antigen receptor. The technical solution of the invention provides a new effective selection for the anti-tumor technical field. The technical scheme is that a single-chain antibody targeting the EGFR is provided. The single-chain antibody is further designed to be constructed into the chimeric antigen receptor by means of a genetic engineering technology, and the structure of the gained chimeric antigen receptor is anti-EGFR (scFv)-IgG2 (Fc)-CD28-CD3 Zeta. According to the genetically engineered lymphocyte targeting the human EGFR, the chimeric antigen receptor is transfected into the lymphocyte by the nucleofaction technology, and thus the nonspecific lymphocyte can be endowed with the capacity of specifically distinguishing the EGFR tumor antigen and targeting and killing the EGFR over-expression tumor cells. According to the technical scheme, the adoptive cell therapy and the genetic therapy are organically combined, so that remarkable effect of killing the tumor is gained, and a novel effective selection is provided for the field.

The invention provides a hydrogel compound, a preparation method and the application. The preparation method comprises the following steps: (1), preparing a hyaluronic acid solution; (2), preparing aldehyde-based modified hyaluronic acid; (3), preparing hydrazide derivatization hyaluronic acid; (4), mixing the aldehyde-based modified hyaluronic acid and the hydrazide derivatization hyaluronic acidinto hydrogel. The method ensures that a final product can be matched with a clinical arthroscopy on the basis of guaranteeing excellent biocompatibility through modification on hyaluronic acid, ensures that hydrogel is rapidly formed in any defective parts through one-time minimally invasive injection, can be further tightly adhered to the defective parts, so as to reduce burden of patients as far as possible, and achieve the effect of promotion of cartilage repair.

The invention provides a traditional Chinese medicine contrast medium adjuvant used for B ultrasonic, which comprises the following materials in part by weight: 10-20 parts of bighead atractylodes rhizome, 10-20 parts of poria cocos, 10-20 parts of turmeric, 10-20 parts of tangerine peel, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of radix aucklandiae, 10-20 parts of Rhizoma atractylodis, 10-20 parts of cuttlebone, 10-20 parts of calcined oyster shell, 10-20 parts of Chinese yam, 10-20 parts of charred triplet, 10-20 parts of myristica fragrans, 10-20 parts of gizzard pepsin, 10-20 parts of rhizome cyperi, 10-20 parts of codonopsis pilosula, 10-20 parts of combined spicebush root, 10-20 parts of eclipta, 10-20 parts of jasmine, 10-20 parts of baical skullcap root and 10-20 parts of field pennycress. The traditional Chinese medicine contrast medium adjuvant used for B ultrasonic provided by the invention not only can adapt to stomach hyperfunction type, but also can adapt to decreased stomach function type, and also can be applied to the mixed type of various flatulence and mucinosis, check time is short, imaging rate is high, and preparation process is simple and practical. The contrast medium adjuvant has no obvious toxic side effect and has prospect on further development research.

The invention relates to the field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine for treatment of halitosis and preparation method thereof. The traditional Chinese medicine for treatment of halitosis is prepared from the following raw materials in parts by mass: 15-25 parts of Scutellaria baicalensis, 10-15 parts of orange peel, 5-15 parts of hawthorn, 2-5 parts of lotus leaves, 4-10 parts of Agastache rugosus and 2-5 parts of honey. The preparation method of the traditional Chinese medicine for treatment of halitosis comprises the following steps of: taking Scutellaria baicalensis, lotus leaves and Agastache rugosus in proportion, adding 250 parts of water, extracting three times, 1 hour each time, filtering and mixing the extracts; further adding orange peel and hawthorn into the mixed extract, decocting for 3 hours in an earthen pot to obtain the pharmaceutical extractum; adding honey into the pharmaceutical extractum, drying in the shade for processing, crushing into powder by a pulverizer, and preparing the powder into a traditional Chinese medicine preparation. The traditional Chinese medicine for treatment of halitosis can take effect quickly, has remarkable curative effect, high cure rate and no toxic or side effect, and is capable of avoiding recurrence of halitosis.

The invention relates to a pain-relieving mixture for the treatment of gouty arthritis, which pertains to the field of pharmaceutical formulations, the technology is characterized in that: the parts by weight of the raw materials are: 6 to 10 percent amur corktree bark, 12 to 16 percent sevenlobed yam rhizome, 4 to 6 percent rhubarb, 8 to 12 percent Japanese honeysuckle stem, 6 to 9 percent Indian iphigenia bulb, 12 to 16 percent spreading hedyotis herb, 6 to 10 percent glabrous greenbrier rhizome, 4 to 6 percent frankincense, 4 to 6 percent myrrh, 6 to 10 percent clematis root, 6 to 10 percent largeleaf gentian root and 6 to 9 percent earthworm, and the sum of the percentages of the components of the raw materials is equal to 100 percent. The invention can effectively alleviate the symptoms of gouty arthritis, prevent and treat the repeated attacks of gouty arthritis, lower blood uric acid, have no toxicity or side effects and have definite efficacy.

The invention discloses an antineoplastic traditional Chinese medicine. The antineoplastic traditional Chinese medicine comprises the following medicinal materials: milkvetch root, Dangshen, red sage root, Chinese angelica, barbat skullcap, heydyotis, bighead atractylodes rhizome, chicken's gizzard membrane, polyporus, Indian mock strawberry, catclaw buttercup root, turmeric root tuber, honey-fried licorice root, scorpion, toad venom and the like, wherein the above-mentioned medicinal materials supplement each other, so absorption and action of the medicinal materials are benefited, stagnation and cold of the medicinal materials are prevented, and effects on tonifying qi in the spleen and the lung, invigorating the spleen, disinhibiting dampness, dispersing phlegm, softening hardness and dispelling stagnated qi are obtained. The antineoplastic traditional Chinese medicine provided by the invention can both be individually used and be cooperatively used with a surgery, radiotherapy and chemotherapy for treatment of a tumor, has the characteristics of fast action, reliable curative effects, no obvious toxic and side effects, capability of controlling growth of the tumor in a short period and eliminating the tumor and capacity of substantially enhancing the habitus of people and improving disease-resistance and restoration capability of people and is an antineoplastic drug with good effects, comprehensive action and no obvious toxic and side effects.

The invention relates to a citric acid tropisetron raw material medicine and a preparation technology of the citric acid tropisetron raw material medicine and an injection liquid, and belongs to the field of chemical pharmacy; in the process of tropisetron salifying, the citric acid is used as acid radical; the chemical name of the citric acid tropane tropisetron is [(1alpha H, 5alpha H)-8-methyl-azepine bicyclo-(3, 2, 1) octyl group-3alpha-]-1H- benzpyrole-3- formic ether citrate; and the molecular formula is C23H28N209. In the process of tropisetron salifying, the tropisetron is dissolved in ethanol; the mixture is added with ethanol solution of the citric acid, evenly stirred and stands till the needed solid is separated out; the crude citric acid tropisetron is filtered, heated and dissolved in distilled water, is added with the activated carbon for backflowing and decoloring, cools and stands after being filtered so as to separate out white cystal; the mixture is filtered; the filter cake is dried and then distilled water is used for the secondary recrystallization to obtain the refined citric acid tropane tropisetron. The clinical research shows that compared with the imported muriatic acid tropisetron injection solution, the citric acid tropisetron injection solution has similar curative effect and safety.

The invention discloses an acyl-tetrahydro-beta-carboline micro-molecular organic compound shown as a structural formula (I) or a hydrate thereof or pharmaceutically acceptable salts, application of a compound containing the acyl-tetrahydro-beta-carboline micro-molecular organic compound provided by the invention or a medical composition thereof to the preparation of medicaments for treating various diseases such as cancer, tumor metastasis and the like, and a preparation method of the acyl-tetrahydro-beta-carboline micro-molecular organic compound provided by the invention and derivatives thereof.

A sobering-up tea is prepared from pueraria root, mulberry fruit, olive and brown sugar through decocting, filter, concentrating, drying, breaking and mixing. Its preparing process is also disclosed.

The invention discloses a traditional Chinese medicine for treating diabetic foot. According to clinical manifestation and syndrome differentiation, the diabetic foot is classified into two types, i.e., toxic heat collateral blocking diabetic foot and blood stasis collateral blocking diabetic foot. Specific to the toxic heat collateral blocking diabetic foot, an internal formula consists of the following raw materials in certain parts by weight: honeysuckle flower, figwort root, coptis root, baical skullcap root, amur corktree bark, philippine violet herb, red paeony root, tree peony bark, earthworm, unprocessed rehmannia root and dahurian angelica root; and specific to the blood stasis collateral blocking diabetic foot, an internal formula consists of the following raw materials in certain parts by weight: suberect spatholobus stem, bupleurum, astragalus, tuber fleeceflower root, bitter orange, peach kernel, yerbadetajo herba ecliptae, common burreed rhizome, zedoary, safflower, szechuan lovage rhizome, Chinese angelica and twotooth achyranthes root. An external foot bathing formula for treating the two types of diabetic foot consists of coptis root, baikal skullcap root, rhubarb, honeysuckle flower, dandelion, safflower, peach kernel, Chinese angelia root tail, suberect spatholobus stem, Chinese taxillus twig, wild celery, cattail pollen, faeces of flying squirrel, wild ginger, fineleaf schizonepeta herb and garden balsam stem. The traditional Chinese medicine is convenient to use and has a remarkable curative effect.

The invention provides tetrandrine organic acid salts. White citric acid tetrandrine salt crystal is prepared through adding tetrandrine to citric acid solution to carry out salt-forming reaction, and drying the obtained tetrandrin citric acid salt solvent. The invention is proved through pharmacological test to have wider and stronger antineoplastic activity, and is proved through in-vitro cell culture system and animal test to have no obvious toxic or side effects on cell growth of a normal person and a tested animal with effective antineoplastic dosage, and have good safety, good water solubility and pH value approximate to the physiological status of human blood, thereby facilitating the improvement on bioavailability and drug action. The tetrandrine organic acid salts can be applied to preparing medicine for treating neopastic diseases. The preparation method has the advantages of simple and feasible process, high success ratio and low cost, and is applicable to scale production. The structural general formula of the tetrandrine organic acid salts is shown as the above.

The invention relates to the genetic engineering field, in particular to a human EpCAM targeted genetically engineered lymphocyte, a preparation method and use thereof. Technically, the invention aimsto provide a new effective means for immunotherapy of tumors. The technical scheme for solving the technical problem of the invention firstly provides a single-chain antibody capable of recognizing human EpCAM, a chimeric antigen receptor (CAR) containing the single-chain antibody, a vector carrying the chimeric antigen receptor, and a lymphocyte modified by the chimeric antigen receptor. After specific recognition of EpCAM overexpressed tumor cells, the EpCAM targeted chimeric antigen receptor modified lymphocyte provided by the invention can play an anti-tumor role through cytokine releaseand cytotoxicity, and can remarkably tumor formation, tumor growth and lung metastasis in vivo, thus having good application prospect.

The invention relates to a Chinese medicine, food and health food, in particular to an aided blood pressure-lowering health product comprising corn stigma, kudzu root, chrysanthemum, hawthorn and lophatherum gracile, especially an aided blood pressure-lowering health drink and a preparation method and usage thereof. The health drink is prepared by raw materials with the following weight proportions: 1-30 portions of the corn stigma, 1-30 portions of the kudzu root, 1-15 portions of the chrysanthemum, 1-15 portions of the hawthorn and 1-15 portions of the lophatherum gracile. The health drink can help lower blood pressure, blood lipid and blood glucose. The health drink is safe and nontoxic and is suitable for long-term consumption.

The invention discloses a novel Chinese medicine composition for treating vertigo, mainly comprising pinellia ternate, fried bighead atractylodes rhizome, gastrodia elata, rhizoma alismatis, acorus tatarinowii, radix bupleuri, radix scutellariae, uncaria, raw oyster shell, and radix cyathulae. The Chinese medicine composition disclosed herein is applied for treating vertigo which is caused by hypertensive, hypertension, cerebral arteriosclerosis, meniere's syndrome, transient ischemic attack, cerebral infarction, and cervical spondylosis, has the symptoms of dizziness, fullness in head or giddiness, is mainly paroxysmal, and can be accompanied by headache, nausea, vomit, tinnitus and deafness, eyes bulging, hot eyes, bitter taste, choking sensation in chest, soreness of waist, body tremor, even faint and the like, and the clinical curative effect is significant. According to the invention, by basically using a medicine having the homology of medicine and food prescribed in national formulary, the advantages of low cost, no obvious side effect, etc. are achieved.

Belonging to the field of medical technologies, the present invention discloses application of aloe-emodin in preparation of drugs reducing blood lipid and liver lipid. Specifically, blood lipid refers to total cholesterol and low density lipoprotein in serum, and liver lipid refers to total cholesterol in liver. Toxicity tests show that aloe-emodin has no obvious toxic and side effect. Pharmacodynamic tests of aloe-emodin show that aloe-emodin can significantly reduce the total cholesterol and low density lipoprotein in hyperlipidemia animal model serum, and has obvious blood lipid reducing effect. At the same time, aloe-emodin can also significantly reduce the total cholesterol content of a hyperlipidemia animal model liver, and has obvious liver lipid reducing effect. Therefore, the invention puts forward the application of aloe-emodin in reduction of blood lipid and liver lipid, aloe-emodin has the characteristics of significant lipid reducing effect, low toxicity, no irritation, low price, and convenient production, transportation, storage and taking, and can have broad application prospects as a blood lipid and liver lipid reducing drug.

The invention relates to a processing technology of a nano silver antibacterial vacuum cup, belongs to the fields of the manufacture technology for utensils for daily use and nano technology, and particularly relates to the technology of application of the nano technology to vacuum cups as the utensils for daily use. The nano silver antibacterial vacuum cup is characterized in that: a nano silver antibacterial film layer is evenly distributed, closely arranged and firmly pasted at the inner surface of a cup body. The manufacture process comprises the steps of: the formations of a shell, a cover and a base, and the silver plating manufacture of an inner container; the manufacture of the inner container comprises the following steps of: washing and drying a raw blank; washing and drying the inner surface of a cup container; washing an electrode; moving the cup container into a cup fixture in a vacuum room, and adjusting the positions of the inner surface of the cup container and the electrode; closing the vacuum room and vacuumizing stage by stage; and electrifying to sputter for vacuum plating. Advantageously, a vacuum cup with an antibacterial function is provided for markets. The vacuum cup has strong restraining and sterilizing functions to dozens of pathogenic microorganisms like colibacillus, Candida albicans, staphylococcus aureus and the like; and the vacuum cup is a quite practical home appliance.

The invention provides a method for purifying gibberellin GA3 and preparing water-soluble pulvis of gibberellin GA3. The invention brings forward control of purity and particle size of gibberellin GA3 and utilization of complex formulation to prepare water-soluble pulvis of gibberellin GA3. According to the invention, a mixed solvent of tetrahydrofuran/ethyl acetate/water is used for recrystallization of a crude product of gibberellin GA3, which enables a reasonable process and simple operation and enables purity of the product in one operation to be more than 98.5% and yield of the product to be more than 90%; the technology of complex formulation is employed and gibberellin GA3 is made to be rapidly dissolved in a water phase and to form a stable disperse phase through using of accessories like an acidic buffer reagent, a dispersant and a surfactant, thereby enabling gibberellin GA3 to be easier to store and transport and more convenient to use and drug effects and the utilization rate to be improved.

The invention provides a Chinese medicinal preparation for treating virus B hepatitis. The preparation is prepared from the following bulk pharmaceuticals in parts by weight: 10-20 parts of chickenbone herb, 10-20 parts of spreading hedyotis herb, 10-20 parts of fortune eupatorium herb, 10-20 parts of fructus gardenia, 10-20 parts of Chinese thorowax root, 10-20 parts of virgate wormwood herb, 10-20 parts of oriental waterplantain rhizome, 10-20 parts of weeping forsythia, 10-20 parts of isatis root, 10-20 parts of Indian buead, 10-20 parts of common selfheal fruit-spike, 10-20 parts of Chinese magnoliavine fruit, 10-20 parts of immature bitter orange, 10-20 parts of large-head atractylodes rhizome, 10-20 parts of dogwood, 10-20 parts of glossy privet fruit, 10-20 parts of white paeony root, 10-20 parts of baikal skullcap root, 10-20 parts of turmeric root-tuber, 10-20 parts of purple perilla, 10-20 parts of szechwan Chinaberry fruit, 10-20 parts of curcuma zedoary and 10-20 parts of large-leaved gentian. The Chinese medicinal preparation has the effects of soothing the liver, regulating the qi, dispelling the stagnation, promoting blood circulation to dissipate stasis, benefiting qi, reinforcing deficiency, supporting the healthy energy, tonifying liver and kidney, clearing away heat and toxic materials, inducing diuresis, detoxifying, clearing away fire of liver, gallbladder and stomach, protecting liver, lowering transaminase, removing toxins and restoring the body immunity function to normal.

The invention provides a traditional Chinese medicine preparation for treating liver cancer, comprising the following raw medicines in parts by weight: 10-20 parts of acanthopanax, 10-20 parts of oldenlandia diffusa, 10-20 parts of radix astragali, 10-20 parts of cambogia, 10-20 parts of glossy privet fruit, 10-20 parts of white atractylodes rhizome, 10-20 parts of radix polygoni multiflori preparata, 10-20 parts of oriental wormwood, 10-20 parts of turmeric, 10-20 parts of selfheal, 10-20 parts of umbellate pore fungus, 10-20 parts of magnolia vine fruit, 10-20 parts of curcuma zedoary, 10-20 parts of tuckahoe, 10-20 parts of eclipta, 10-20 parts of root of red-rooted salvia, 10-20 parts of white peony root, 10-20 parts of barbed skullcap herb, 10-20 parts of baical skullcap root, 10-20 parts of epimedium, 1-10 parts of toad venom and 1-10 parts of scorpion. The traditional Chinese medicine preparation for treating liver cancer has the beneficial effects of prolonging the life time of inoperable patients, playing an adjuvant treating effect on patients treated mainly by operation, radiation treatment and chemo-treatment, and having certain curative effects on liver cancer-specific backgrounds of liver diseases such as hepatitis and liver cirrhosis.