19results about How to "No obvious side effects" patented technology

The application discloses a traditional Chinese medicine extract with antibacterial, anti-inflammatory and antipyretic effects and an active component self-assembled nanomaterial of the traditional Chinese medicine extract and application, wherein the polygonum capitatum extract and the active component self-assembled nanomaterial have the effects of inhibiting bacteria and relieving inflammation and can be used for treating atopic dermatitis. The in-vitro bacteriostatic experiment and animal experiment results verify that the polygonum capitatum extract and the active component self-assembled nanomaterial have the effects of resisting bacteria and inflammation and can effectively treat atopic dermatitis.

This invention relates to the field of traditional Chinese medicine composition technology, and particularly to a method of using, preparing, and applying a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from raw materials comprising a first component, a second component, a third component, and a fourth component: the first component comprises a mixture of raw oyster shell, prunella vulgaris, and fritillaria thunbergii; the second component comprises a mixture of angelica sinensis, scorpion, notoginseng, and cattail pollen; the third component comprises one or more of lindera strychnifolia, chuanxiong rhizome, cyperus rotundus, and corydalis yanhusuo; the fourth component comprises one or more of fenugreek, angelica dahurica, and fennel; the mass ratio of the first component to the second component is 1.3–2:1. This traditional Chinese medicine composition can not only significantly prevent and alleviate dysmenorrhea symptoms in patients with acute menstrual cramps (AM), but also improve other accompanying symptoms during menstruation in AM patients, such as heavy menstrual bleeding.

This invention discloses a compound preparation for treating vascular dementia and its preparation method. The active pharmaceutical ingredient consists of protopanaxadiol and gallic acid in a 1:1 mass ratio, and the dosage form is liposomes. The preparation method includes extraction, mixing, liposome preparation, and optional freeze-drying steps: protopanaxadiol and gallic acid are extracted and purified from ginseng rhizome and Terminalia chebula fruit, respectively. After mixing, they are combined with phospholipids and cholesterol to prepare a lipid membrane. The membrane is then homogenized by hydration, low-temperature ultrasound, and high-pressure microfluidic jet to obtain a homogeneous liposome suspension, which can be further freeze-dried into a freeze-dried powder. The 1:1 composition of protopanaxadiol and gallic acid targets multiple points on the pathological mechanism of vascular dementia, showing significant therapeutic effects and broad application prospects. This preparation uses a liposome dosage form to improve the bioavailability of the active ingredient, the preparation process parameters are controllable, the active ingredient has high purity, the liposomes have uniform particle size, high encapsulation efficiency, and good stability.

The invention provides a composition for improving the thrombolysis capacity of a human body, a preparation method and application thereof.The composition is prepared from, by weight, 5-30 parts of earthworm protein, 30-120 parts of hippophae rhamnoides total flavone extract, 50-150 parts of silymarin extract, 20-80 parts of maltodextrin and 15-60 parts of pregelatinized starch, the earthworm protein activates a fibrinolytic system to promote t-PA to release and dissolve thrombus, and the hippophae rhamnoides total flavone extract activates the fibrinolytic system to promote t-PA to release and dissolve thrombus; the hippophae rhamnoides total flavonoids regulate the ratio of PGI2 / TXA2 to inhibit platelet aggregation and reduce blood fat, the silymarin protects the liver function to enhance LDL-C metabolism clearing, the hippophae rhamnoides total flavonoids, the silymarin and the hippophae rhamnoides total flavonoids cooperate to form a thrombolysis-antithrombosis-metabolism regulation three-dimensional intervention system, a whole-course low-temperature mixing direct tabletting process is adopted

This invention provides a traditional Chinese medicine composition for treating renal edema, pyelonephritis with ascites, and nephritis. It consists of over 20 herbs including Atractylodes lancea, Areca catechu, Saposhnikovia divaricata, and Alisma plantago-aquatica (specific formulation details can be found in the original text). It can be prepared as pills, granules, or decoctions for oral administration. Core efficacy: 1. Promotes diuresis and reduces swelling, eliminating renal ascites; 2. Clears heat and detoxifies, anti-inflammatory and antibacterial (synergistic effect on fungal infections and cervical erosion); 3. Regulates renal function and improves abnormal uric acid metabolism. Treatment plan: Mild cases: Use five basic formulas (①-⑤) composed of Codonopsis pilosula, Poria cocos, etc., taken three times daily; Severe cases: Use a potent diuretic formula containing Akebia trifoliata and Euphorbia pekinensis (one spoonful of pills twice daily); Treatment course is approximately one month, with a follow-up examination after three months. Advantages: Cure rate reaches 90%, low recurrence rate – pure traditional Chinese medicine preparation, no significant toxic side effects; also treats complications (fungal infection, cervical lesions). This treatment plan has been clinically verified through three generations and has significant efficacy in treating renal edema, ascites, and nephritis.

The invention relates to the field of A61K8 / 00, in particular to a composition for promoting rapid growth of hair and application of the composition. By adopting the specific amino acid composition, the physiological active component, the plant source glucoside, the protein hydrolysate, the diguanide tetraphosphate and the anti-inflammatory agent, through the synergistic effect of all the active raw materials, the provided composition for promoting rapid growth of hair is added to prepare hair washing and hair care products, and the hair washing and hair care products are applied to people with alopecia to use or treat the alopecia. Hair stem cell stimulation and rapid hair follicle regeneration are effectively induced, scalp aging is prevented, the treatment effect is remarkable, and no obvious side effect exists.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a herbal antibacterial hydrogel for ulcer healing, its preparation method, and its application. The hydrogel is composed of a herbal composition and a matrix. The herbal composition includes dandelion, angelica, scrophularia, forsythia, phellodendron, atractylodes, angelica dahurica, and raw licorice. The matrix contains chitosan, polyvinyl alcohol, water, and glacial acetic acid. The effective components of the herbal medicine are extracted by decoction, concentrated, and freeze-dried to obtain a freeze-dried powder. This powder is then mixed with a chitosan aqueous solution and cross-linked using a liquid nitrogen cyclic freezing method to form the hydrogel. This invention closely addresses the core pathogenesis of diabetic foot ulcers—"blood stasis, dampness, and heat (toxin)"—allowing the various herbs to synergistically exert their effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, drying dampness and astringing sores, and nourishing blood and promoting tissue regeneration. The chitosan matrix endows the hydrogel with good biocompatibility, antibacterial properties, and sustained-release drug properties, which can improve the microenvironment of the ulcer wound, inhibit inflammatory responses, and promote granulation tissue growth, effectively promoting the healing of skin sores such as diabetic foot ulcers, and has broad application prospects.

This invention belongs to the field of medicinal chemistry, specifically relating to a mitochondrial-dequinoline chloride-hyaluronic acid compound, its preparation method, and its application. The rotenol-dequinoline chloride-hyaluronic acid compound has the following structural formula, where n is 2. Based on the anticancer activity of rotenone, this invention utilizes reduction, esterification, and two amide reactions to successfully link rotenol, dequinoline chloride, and hyaluronic acid via amide bonds. Subsequently, these components are successfully self-assembled into spherical nanoparticles using ultrasound, constructing a rotenol-dequinoline chloride-hyaluronic acid nanosystem for tumor therapy. After targeted delivery of these nanoparticles to tumor cells, both rotenol and dequinoline chloride synergistically act on the mitochondria, forming a dual-drug delivery system that generates a large amount of ROS, thereby inducing apoptosis and effectively inhibiting tumor growth and migration.

The application discloses a compound based on a PROTAC strategy and a preparation method, a pharmaceutical composition and application thereof, discloses a compound with AR / AR-V7 protein degradation activity and a preparation method, a pharmaceutical composition and application thereof. The structure of the compound is as shown in the formula I. The compound can effectively degrade AR / AR-V7 proteins in vivo and in vitro, has a significant antitumor effect, has no obvious toxic side effects, and can be used for treating castration-resistant prostate cancer. The preparation method of the compound is simple and easy to operate, and is beneficial to structural expansion.

The invention discloses a powerful external Chinese herbal medicine composition as well as a preparation method and application thereof, and belongs to the technical field of external Chinese herbal medicine preparations. The composition is formed by compounding active ingredients of traditional Chinese medicinal materials and a matrix of an external preparation, the formula compatibility is reasonable, medicinal materials such as oxalis corymbosa, herba violae, dandelion, paris polyphylla, radix tinosporae and pseudo-ginseng are selected, and the composition has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain, removing slough and promoting tissue regeneration, and inhibiting bacteria and repairing. The process of water extraction, concentration, homogenization and sterile filling is adopted, operation is easy and convenient, the method is suitable for industrial production, and external dosage forms such as gel and cream can be prepared. The product has a good effect on diseases such as traumatic injuries, bruise and induration, burns and scalds, sores and ulcers, pyogenic infections and the like, the gel is refreshing and breathable, the gel is suitable for seepage wounds and used in summer, the cream is moist and slow-release, the cream is suitable for deep bruise and dry wounds and used in winter, the applicability is wide, the drug property is mild, and the good clinical practicability is achieved.

The invention provides a medicinal and edible composition with gastrointestinal regeneration and a preparation method thereof, and relates to the field. The medicinal and edible composition capable of regenerating intestines and stomach comprises the following raw materials: 10-30 parts of cordyceps sobolifera, 10-30 parts of Chinese yam, 10-25 parts of hericium erinaceus, 8-20 parts of poria cocos, 8-18 parts of gordon euryale seed, 5-15 parts of Chinese date, 5-15 parts of lotus seed, 5-12 parts of sea-buckthorn, 3-10 parts of hawthorn, 10-30 parts of honey, 5-10 parts of American ginseng extract, 3-6 parts of wolfberry extract, 2-4 parts of astragalus extract and 1-3 parts of xylooligosaccharide. Through the scientific and reasonable raw material ratio, the synergistic interaction effect of all the components is exerted, gastrointestinal mucosa repair and tissue regeneration are promoted, the gastrointestinal digestion and absorption functions are improved, and the gastrointestinal immunity is enhanced; the invention also provides a preparation method of the composition, so that the product quality is stable, and the effective components are fully reserved.

The present application relates to the technical field of traditional Chinese medicine extraction, and discloses a water chestnut peel extract and application thereof in preparation of a medicine for treating chloasma; during preparation of the extract, low-temperature extraction is carried out by using an acid-alcohol mixed solvent, and enrichment is carried out by using macroporous resin purification, so that the water chestnut peel extract with high purity of active ingredients and complete retention can be prepared, the utilization rate of active ingredients in the water chestnut peel is effectively improved, and resource waste is reduced. The water chestnut peel extract provided by the present application can effectively inhibit tyrosinase activity, and shows excellent treatment potential for chloasma, a pigment deposition disease, thereby providing a solution to the current situation that chloasma is difficult to treat.

The invention discloses mussel mucoprotein water and a preparation process thereof, and the mussel mucoprotein water comprises the following components in parts by mass: 5-12 parts of mussel mucoprotein; 3 to 8 parts of a hydroxylated chitosan-polyethylene glycol grafted copolymer; 4 to 9 parts of modified sodium alginate; 2 to 6 parts of beta-cyclodextrin embedded theabrownin; 1 to 4 parts of nano hydroxyapatite; 1-3 parts of glycerol; 60 to 85 parts of deionized water; through the synergistic effect of the four innovative components and the mussel mucoprotein, the dressing has excellent biological adhesion, mechanical properties, antibacterial and anti-inflammatory properties and healing promotion effects, and the problems that an existing dressing is single in function and insufficient in performance are solved; the adopted raw materials are natural high polymer materials or modified products with excellent biocompatibility, and after purification treatment, the impurity content is low, the biological safety is high, and no obvious toxic or side effect exists; the prepared hydrogel dressing is good in moisture retention and air permeability, can meet the healing requirements of various acute wounds and chronic wounds, and has wide clinical application prospects.

This invention discloses a Sophora japonica polysaccharide HEP-3A, its preparation method, and its applications, belonging to the field of biomedicine. The invention obtains a novel acid-base amphoteric polysaccharide HEP-3A by defatting, hot water extraction, fractional alcohol precipitation, ion exchange, and gel column chromatography of Sophora japonica raw materials. Polysaccharide HEP-3A is composed of nine monosaccharides, with a well-defined structure and high purity; moreover, the preparation process is simple and controllable, with high yield, suitable for large-scale production. Experimental results show that polysaccharide HEP-3A can target and inhibit the binding of HIF-1α / β to CBP / p300, blocking the HIF-1 signaling pathway and inhibiting tumor angiogenesis, exhibiting broad-spectrum antitumor activity. In a liver cancer model, the tumor inhibition rate can reach 77.96%, and it has excellent safety, making it suitable for the preparation of antitumor drugs. This invention provides a new candidate compound for the development of new antitumor drugs.

The invention relates to application of erucic acid in flu secondary bacterial infection, and relates to the technical field of medicines. The erucic acid improves the weight change and the lung index of a patient suffering from the influenza secondary bacterial infection by remarkably reducing the bacterial adhesion condition in the influenza secondary bacterial infection, reduces the lung virus titer and the bacterial load and improves lung pathological injury, and has an excellent application prospect in the aspect of development of medicines for treating the influenza secondary bacterial infection.

The invention discloses a novel application of 2-myricetin-based diselenide. As a raw material medicine with an immunological enhancement function, the compound is particularly suitable for preparing immunoregulation medicines, health-care foods and dietary supplements which are beneficial to enhancing immunity, and can be widely applied to daily health care and auxiliary conditioning of people with low immunologic functions.

This invention, entitled "Application of 6-Methylcoumarin in the Preparation of Products for Treating Intestinal Diseases and Improving the Intestinal Barrier," belongs to the fields of biomedical technology and food. The technical problem to be solved is the poor safety, side effects, and drug resistance of existing IBD clinical drugs. The key technical solutions are the application of 6-methylcoumarin in the preparation of products that improve intestinal barrier function, its application as a treatment for intestinal barrier repair drugs, and its application as a treatment for intestinal barrier-related intestinal diseases.

The application discloses a traditional Chinese medicine composition for clearing heat and resolving toxins, benefiting the throat and eliminating swelling, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: Houttuynia cordata 10-20 parts, Astragalus root 8-15 parts, Andrographis 8-15 parts, Figwort 8-15 parts, Platycodon 8-15 parts, Monotropa 8-15 parts, Honeysuckle 2-6 parts, Bupleurum 2-6 parts, Belamcanda 2-6 parts, Peucedanum 2-6 parts, Marsh Marigold 1-4 parts and artificial ox gall 0.1-0.6 parts. The traditional Chinese medicine composition has the effects of clearing heat and resolving toxins, benefiting the throat and eliminating swelling, relieving cough and reducing sputum, and is used for treating fever caused by wind-heat invading the lung and lung heat being in excess, nasal discharge of sticky or yellow phlegm, sore throat, cough and expectoration, yellow and thick sputum, headache and body pain, red tongue and yellow tongue fur and the like, and is also used for treating influenza, acute upper respiratory tract infection, acute pharyngitis, tonsillitis and the like. The effect is better than that of each proportion.

The invention discloses a separation method and application of a sheep placenta-derived exosome for treating psoriasis. Application of the sheep placenta-derived exosome in preparation of drugs for treating the following diseases: (1) psoriasis; (2) diabetic foot; and (3) wound healing. When the sheep placenta-derived exosome separated by the separation method disclosed by the invention is used for performing intervention treatment on a C57 wild type mouse psoriasis model, the sheep placenta-derived exosome is found to be capable of remarkably promoting pathological improvement of psoriasis and reducing formation of skin erythema and scurf; skin inflammation and abnormal keratinogenesis caused by the psoriasis are reduced, the effect of improving and treating the psoriasis is achieved, and no obvious side effect exists. In general, the invention can be used as a strategy and means for treating psoriasis.