67results about How to "No obvious side effects" patented technology

The invention belongs to the technical field of medicines, and particularly discloses application of moss phenol glucoside in preparation of medicines for preventing and / or treating tumors. According to the method, activated CD8 + T cells, MC38-OVA cells and traditional Chinese medicine monomeric compounds are co-cultured, the traditional Chinese medicine monomeric compounds capable of effectively promoting the anti-tumor activity of the CD8 + T cells are selected by utilizing a high-content screening technology, and finally, the experiment is carried out by taking the moss phenol glucoside as a research object. In-vitro experiment results show that the moss phenol glucoside can significantly promote T cell activation, promote release of cell factors such as IFN-gamma and TNF-alpha, and enhance the killing effect of T cells on tumors. A mouse in-vivo tumor-bearing experiment result shows that the moss phenol glucoside can promote the anti-tumor activity of T cells so as to inhibit tumor growth, has no obvious toxic or side effect, can be used for preparing the medicine for preventing and / or treating tumors, and has a potential clinical application prospect and a relatively high economic value.

The invention discloses application of sclareol in preparation of drugs for resisting porcine reproductive and respiratory syndrome virus, and belongs to the field of veterinary drugs. According to the invention, Marc-145 cells are taken as host cells, a plurality of porcine reproductive and respiratory syndrome virus strains are selected for infection, and the antiviral performance of sclareol is tested; experimental results show that 30-50 [mu] M sclareol has no obvious toxicity to host cells, and can significantly inhibit infection of different porcine reproductive and respiratory syndrome virus strains in the host cells. The sclareol has good activity of resisting porcine reproductive and respiratory syndrome virus infection, and the sclareol is a medicine with a natural source, has the advantages of safety, few side effects, low metabolic residue and no pollution, and provides a reliable basis for treatment, prevention and control of porcine reproductive and respiratory syndrome.

The invention provides application of asperuloside in preparation of a medicine for treating diabetic nephropathy, the structural formula of the asperuloside is as shown in the specification, and imgabs0 #. Experiments find that the asperuloside has the effect of delaying the diabetic nephropathy of db / db mice, and a new method is provided for treating the diabetic nephropathy.

The invention provides application of triptophenolide in preparation of a medicine for treating diabetic nephropathy, the structural formula of the triptophenolide is as shown in the specification, and # imgabs0 #. Experiments find that the triptophenolide has the effect of delaying the diabetic nephropathy of db / db mice, and a new method is provided for treating the diabetic nephropathy.

The embodiment of the invention belongs to the technical field of biological medicines, and particularly relates to mRNA and mRNA lipid nanoparticle compounds for preventing and treating triple negative breast cancer as well as a preparation method and application of the mRNA and mRNA lipid nanoparticle compounds. The mRNA comprises a coding region of alpha-whey protein. The mRNA lipid nanoparticle compound comprises a nanoparticle lipid shell and the mRNA, the mRNA is encapsulated in the lipid shell, and a coding region of the alpha-whey protein has a nucleotide sequence as shown in SEQ ID NO. 6. According to the alpha-whey protein mRNA provided by the invention, mRNA for preventing and treating triple negative breast cancer is delivered to a body through a lipid nanoparticle delivery system, so that alpha-whey protein is transiently expressed, cellular response and humoral immunity of the body are activated, infiltration of CD8 positive T cells is promoted, a specific antibody is formed, and the effect of preventing or killing tumor cells is achieved; no obvious toxic or side effect exists.

The invention relates to application of a ventral hippocampal region transferrin receptor 1 inhibitor in preparation of a medicine for preventing and / or treating anxiety disorder, and belongs to the technical field of biological medicine. The application of the inhibitor for interfering with the animal brain ventral hippocampal region transferrin receptor 1 (TfR1) in the drugs for preventing and / or treating anxiety is discovered and proposed for the first time. Animal experiments prove that anxiety disorder caused by social isolation stress is closely related to TfR1 in a brain abdominal side hippocampus area of an animal, and when the animal shows anxiety symptom, the expression level of TfR1 is improved, so that the iron concentration in the brain abdominal side hippocampus area is improved to cause iron disorder. On the basis of the research, an inhibitor for interfering with the TfR1 in the belly hippocampus area of the brain of the animal is injected into an anxiety model animal, social isolation treatment is continued, the anxiety behavior of the animal in a social isolation treatment group is improved, and the effect of treating the anxiety is achieved.

The application discloses a traditional Chinese medicine extract with antibacterial, anti-inflammatory and antipyretic effects and an active component self-assembled nanomaterial of the traditional Chinese medicine extract and application, wherein the polygonum capitatum extract and the active component self-assembled nanomaterial have the effects of inhibiting bacteria and relieving inflammation and can be used for treating atopic dermatitis. The in-vitro bacteriostatic experiment and animal experiment results verify that the polygonum capitatum extract and the active component self-assembled nanomaterial have the effects of resisting bacteria and inflammation and can effectively treat atopic dermatitis.

This invention relates to the field of traditional Chinese medicine composition technology, and particularly to a method of using, preparing, and applying a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from raw materials comprising a first component, a second component, a third component, and a fourth component: the first component comprises a mixture of raw oyster shell, prunella vulgaris, and fritillaria thunbergii; the second component comprises a mixture of angelica sinensis, scorpion, notoginseng, and cattail pollen; the third component comprises one or more of lindera strychnifolia, chuanxiong rhizome, cyperus rotundus, and corydalis yanhusuo; the fourth component comprises one or more of fenugreek, angelica dahurica, and fennel; the mass ratio of the first component to the second component is 1.3–2:1. This traditional Chinese medicine composition can not only significantly prevent and alleviate dysmenorrhea symptoms in patients with acute menstrual cramps (AM), but also improve other accompanying symptoms during menstruation in AM patients, such as heavy menstrual bleeding.

The invention provides a vaginal flora repairing liquid and a preparation method thereof. Specifically, the repair liquid prepared from the lactobacillus paracasei CGMCC No. 1.12731, the lactobacillus rhamnosus CGMCC 24282 and the lactobacillus gasseri CGMCC No. 22909 in a specific mass ratio can be used for well killing pathogenic bacteria, has no obvious toxic or side effect and is low in cost. The broad-spectrum vaginitis bactericidal peptide YDG-C screened by the invention is further added into the repair liquid, so that the treatment effect on bacterial vaginitis can be further improved. The preparation method is simple, low in cost and suitable for large-scale popularization and application.

This invention discloses a compound preparation for treating vascular dementia and its preparation method. The active pharmaceutical ingredient consists of protopanaxadiol and gallic acid in a 1:1 mass ratio, and the dosage form is liposomes. The preparation method includes extraction, mixing, liposome preparation, and optional freeze-drying steps: protopanaxadiol and gallic acid are extracted and purified from ginseng rhizome and Terminalia chebula fruit, respectively. After mixing, they are combined with phospholipids and cholesterol to prepare a lipid membrane. The membrane is then homogenized by hydration, low-temperature ultrasound, and high-pressure microfluidic jet to obtain a homogeneous liposome suspension, which can be further freeze-dried into a freeze-dried powder. The 1:1 composition of protopanaxadiol and gallic acid targets multiple points on the pathological mechanism of vascular dementia, showing significant therapeutic effects and broad application prospects. This preparation uses a liposome dosage form to improve the bioavailability of the active ingredient, the preparation process parameters are controllable, the active ingredient has high purity, the liposomes have uniform particle size, high encapsulation efficiency, and good stability.

The invention provides a composition for improving the thrombolysis capacity of a human body, a preparation method and application thereof.The composition is prepared from, by weight, 5-30 parts of earthworm protein, 30-120 parts of hippophae rhamnoides total flavone extract, 50-150 parts of silymarin extract, 20-80 parts of maltodextrin and 15-60 parts of pregelatinized starch, the earthworm protein activates a fibrinolytic system to promote t-PA to release and dissolve thrombus, and the hippophae rhamnoides total flavone extract activates the fibrinolytic system to promote t-PA to release and dissolve thrombus; the hippophae rhamnoides total flavonoids regulate the ratio of PGI2 / TXA2 to inhibit platelet aggregation and reduce blood fat, the silymarin protects the liver function to enhance LDL-C metabolism clearing, the hippophae rhamnoides total flavonoids, the silymarin and the hippophae rhamnoides total flavonoids cooperate to form a thrombolysis-antithrombosis-metabolism regulation three-dimensional intervention system, a whole-course low-temperature mixing direct tabletting process is adopted

This invention provides a traditional Chinese medicine composition for treating renal edema, pyelonephritis with ascites, and nephritis. It consists of over 20 herbs including Atractylodes lancea, Areca catechu, Saposhnikovia divaricata, and Alisma plantago-aquatica (specific formulation details can be found in the original text). It can be prepared as pills, granules, or decoctions for oral administration. Core efficacy: 1. Promotes diuresis and reduces swelling, eliminating renal ascites; 2. Clears heat and detoxifies, anti-inflammatory and antibacterial (synergistic effect on fungal infections and cervical erosion); 3. Regulates renal function and improves abnormal uric acid metabolism. Treatment plan: Mild cases: Use five basic formulas (①-⑤) composed of Codonopsis pilosula, Poria cocos, etc., taken three times daily; Severe cases: Use a potent diuretic formula containing Akebia trifoliata and Euphorbia pekinensis (one spoonful of pills twice daily); Treatment course is approximately one month, with a follow-up examination after three months. Advantages: Cure rate reaches 90%, low recurrence rate – pure traditional Chinese medicine preparation, no significant toxic side effects; also treats complications (fungal infection, cervical lesions). This treatment plan has been clinically verified through three generations and has significant efficacy in treating renal edema, ascites, and nephritis.

The invention relates to the technical field of medicine, and particularly discloses an endometriosis prescription for dysmenorrhea with endometriosis. Comprising the following raw materials: 10-15 parts of radix salviae miltiorrhizae, 7-10 parts of rhizoma curcumae, 2-3 parts of flos carthami, 7-10 parts of vinegar turtle shell, 10-15 parts of salted radix achyranthis bidentatae, 7-10 parts of rhizoma corydalis, 10-15 parts of prepared fingered citron, 5-8 parts of radix bupleuri, 10-15 parts of radix paeoniae alba, 10-15 parts of caulis spatholobi, 10-15 parts of poria cocos, 7-10 parts of herba taxilli, 7-10 parts of radix dipsaci, 3-5 parts of fructus amomi, 7-10 parts of endothelium corneum gigeriae galli, 10-15 parts of hawthorn and 7-10 parts of liquorice. The agreement prescription of the internal different prescription has obvious curative effects on improvement of dysmenorrhea symptoms of EMs patients, reduction of tentacle nodules and appendage masses, improvement of pelvic cavity states, increase of pregnancy rates and the like, and is safe and free of obvious toxic and side effects.

The invention relates to the field of A61K8 / 00, in particular to a composition for promoting rapid growth of hair and application of the composition. By adopting the specific amino acid composition, the physiological active component, the plant source glucoside, the protein hydrolysate, the diguanide tetraphosphate and the anti-inflammatory agent, through the synergistic effect of all the active raw materials, the provided composition for promoting rapid growth of hair is added to prepare hair washing and hair care products, and the hair washing and hair care products are applied to people with alopecia to use or treat the alopecia. Hair stem cell stimulation and rapid hair follicle regeneration are effectively induced, scalp aging is prevented, the treatment effect is remarkable, and no obvious side effect exists.

The invention discloses a medicinal and edible formula for resisting cold and enhancing immunity. The invention belongs to the technical field of medicine and food, according to the theory of traditional Chinese medicine, a plurality of medicine and food homologous raw materials with the effects of resisting cold and enhancing immunity are selected for scientific compatibility; the raw materials used in the traditional Chinese medicine composition cooperate with each other, so that the traditional Chinese medicine composition not only can effectively prevent cold, but also can relieve symptoms and promote physical rehabilitation during a cold period, and meanwhile, can improve organism immunity and enhance defense capability of organisms to various diseases after being taken for a long time; the health-care food adopts medicinal and edible raw materials, is high in safety, has no obvious toxic or side effect, is suitable for people of different ages to take for a long time, and is used as a functional food or health-care product for daily health care and cold prevention; the preparation method is simple and easy to implement, can be prepared into different oral dosage forms according to actual requirements, and is convenient to produce, store, transport and take.

The present invention provides a Chinese medicine composition for treating or preventing Alzheimer's disease, and its preparation method and application, wherein the Chinese medicine composition comprises the following raw materials in parts by mass: 10-20 parts of ginseng, 10-20 parts of polygala, 10-20 parts of calamus, 10-20 parts of tuckahoe, 10-20 parts of yam, 10-20 parts of polygonatum, 10-20 parts of green tea pigments and 10-20 parts of quercetin, and optionally comprises 0.1-0.5 parts of black pepper. The Chinese medicine composition of the present invention has a significant therapeutic effect on 5XFAD transgenic AD mice, which is specifically manifested in that daily oral administration of the Chinese medicine composition of the present invention improves the spatial learning and memory disorders of dementia mice, reduces the deposition of amyloid plaques in the dentate gyrus of the hippocampus of mice, and significantly inhibits the generation of Aβ without causing liver and kidney toxicity and weight loss. Therefore, the Chinese medicine composition of the present invention is a safe and effective method for treating AD.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a herbal antibacterial hydrogel for ulcer healing, its preparation method, and its application. The hydrogel is composed of a herbal composition and a matrix. The herbal composition includes dandelion, angelica, scrophularia, forsythia, phellodendron, atractylodes, angelica dahurica, and raw licorice. The matrix contains chitosan, polyvinyl alcohol, water, and glacial acetic acid. The effective components of the herbal medicine are extracted by decoction, concentrated, and freeze-dried to obtain a freeze-dried powder. This powder is then mixed with a chitosan aqueous solution and cross-linked using a liquid nitrogen cyclic freezing method to form the hydrogel. This invention closely addresses the core pathogenesis of diabetic foot ulcers—"blood stasis, dampness, and heat (toxin)"—allowing the various herbs to synergistically exert their effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, drying dampness and astringing sores, and nourishing blood and promoting tissue regeneration. The chitosan matrix endows the hydrogel with good biocompatibility, antibacterial properties, and sustained-release drug properties, which can improve the microenvironment of the ulcer wound, inhibit inflammatory responses, and promote granulation tissue growth, effectively promoting the healing of skin sores such as diabetic foot ulcers, and has broad application prospects.

The invention provides a traditional Chinese medicine composition for treating primary sicca syndrome complicated with interstitial lung disease and application of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-15g of radix glehniae, 10-15g of radix ophiopogonis, 15-30g of radix pseudostellariae, 10-20g of curcuma zedoary, 6-12g of roasted stiff silkworm and 15-30g of wild buckwheat rhizome. The traditional Chinese medicine composition can safely and effectively improve the respiratory function, dry mouth, dry eye and other symptoms of pSS-ILD patients, improve the life quality of the patients and delay the disease progression, has no obvious side effect, and is simple in formula and low in cost.

The invention discloses a traditional Chinese medicine composition for clearing away heat and toxic materials and relieving sore throat and swelling and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of houttuynia cordata, 8-15 parts of astragalus membranaceus, 8-15 parts of andrographis paniculata, 8-15 parts of radix scrophulariae, 8-15 parts of platycodon grandiflorum, 8-15 parts of pithecellobium clypearia, 2-6 parts of honeysuckle, 2-6 parts of radix bupleuri, 2-6 parts of blackberry lily, 2-6 parts of radix peucedani, 1-4 parts of trollflower and 0.1-0.6 part of calculus bovis factitius. The traditional Chinese medicine composition disclosed by the invention has the effects of clearing away heat and toxic materials, relieving sore throat and diminishing swelling, and relieving cough and reducing sputum, and is mainly used for treating wind-heat type common cold, fever caused by wind-heat affecting lung and excessive lung heat, viscous nasal discharge or yellow nasal discharge, swollen sore throat, cough and expectoration, yellow and thick phlegm, head and body pain, red tongue and yellow fur and the like; the traditional Chinese medicine composition can be used for treating influenza, acute upper respiratory infection, acute pharyngitis, amygdalitis and the like with the syndromes. And the effect is better than that of each contrast.

The invention discloses a method for preparing a fat microcapsule with the function of activating brown fat. The invention adopts maltodextrin and octenyl succinate starch as wall materials, and uses hairtail waste refined fish oil and triacetin as core materials, and obtains a fat microcapsule powder product with the function of activating brown fat through high-speed dispersion homogenization and freeze drying. The fat microcapsule prepared by the method is rich in unsaturated fatty acids, can promote brown fat differentiation and heat production, activate brown fat activation, and then significantly reduce the weight of mice, thereby playing a role in preventing and treating obesity and related diseases.

The invention discloses an application of a novel nano preparation containing zingiberenone A in preparation of antitumor drugs. The nano preparation comprises aminated dendritic mesoporous silica and zingiberenone A loaded on the aminated dendritic mesoporous silica. According to the invention, aminated dendritic mesoporous silica is adopted to load zingiberenone A, and a novel nano preparation which has high drug loading capacity, high encapsulation efficiency and high biocompatibility and contains zingiberenone A. The preparation has relatively low cytotoxicity, can be rapidly taken by tumor cells, remarkably enhances the capability of zingiberenone A in removing tumor cells, and can be used for preparing the nano preparation. The pharmaceutical composition can effectively inhibit proliferation of tumors in vivo, has a better treatment effect than that of a clinically common anti-tumor drug darafenib, and has a wide application prospect.

The invention belongs to the technical field of cosmetics, and particularly relates to a whitening composition containing American ginseng and folium mori and application of the whitening composition. The whitening composition is prepared from the following components: folium mori, radix panacis quinquefolii, (-)-Podophyllotoxin and (+)-Glaucarubinone, and is characterized in that the folium mori is used as a raw material; experimental results show that the composition has an obvious inhibiting effect on tyrosinase activity and tyrosine related protein expression, and then the effect of whitening the skin is achieved. Therefore, the whitening composition disclosed by the invention can be used for preparing various skin whitening products or products for inhibiting melanin synthesis or products for improving skin pigmentation, and has a wide market prospect.

The invention discloses an external traditional Chinese medicine composition for treating breast yin syndrome and half-yin and half-yang syndrome swelling and ulcer as well as a preparation method and application thereof, the traditional Chinese medicine composition provided by the invention comprises 9 warm medicines and 3 cold medicines, the cold and warm medicines are taken into account and warm is taken as a main part, the whole formula does not contain pure tonifying medicines or pure discharging medicines, and the traditional Chinese medicine composition has the effects of warming, dispelling cold coagulation, removing stagnation and activating blood. The external traditional Chinese medicine ointment prepared from the traditional Chinese medicine composition is clear in clinical curative effect on breast yin syndrome and half-yin and half-yang syndrome swelling and ulcer, free of obvious toxic and side effects, free of traumatic damage, low in recurrence rate, good in patient compliance and worthy of being vigorously popularized and applied clinically.

This invention belongs to the field of medicinal chemistry, specifically relating to a mitochondrial-dequinoline chloride-hyaluronic acid compound, its preparation method, and its application. The rotenol-dequinoline chloride-hyaluronic acid compound has the following structural formula, where n is 2. Based on the anticancer activity of rotenone, this invention utilizes reduction, esterification, and two amide reactions to successfully link rotenol, dequinoline chloride, and hyaluronic acid via amide bonds. Subsequently, these components are successfully self-assembled into spherical nanoparticles using ultrasound, constructing a rotenol-dequinoline chloride-hyaluronic acid nanosystem for tumor therapy. After targeted delivery of these nanoparticles to tumor cells, both rotenol and dequinoline chloride synergistically act on the mitochondria, forming a dual-drug delivery system that generates a large amount of ROS, thereby inducing apoptosis and effectively inhibiting tumor growth and migration.

The invention provides an application of a middle-jiao-regulating decoction in treating neonatal necrotizing enterocolitis, the active components of the middle-jiao-regulating decoction are prepared from the following raw materials: codonopsis pilosula, dried ginger, honey-fried licorice root and bighead atractylodes rhizome, and the mass ratio of codonopsis pilosula to dried ginger to honey-fried licorice root to bighead atractylodes rhizome is (1-2): (1-2): (1-2): (1-2). In combination with years of clinical treatment experience and a large amount of research, the inventor finds that the Zhongzhong decoction has an obvious treatment effect on NEC, the NEC tissue damage degree of newborn rats can be effectively reduced, the intestinal barrier function is improved, the NEC occurrence rate is remarkably reduced, and the survival rate is increased. In addition, the middle warmer regulating decoction has no obvious toxic and side effects when being used for treating neonatal necrotizing enterocolitis, and is high in safety.

The application discloses a compound based on a PROTAC strategy and a preparation method, a pharmaceutical composition and application thereof, discloses a compound with AR / AR-V7 protein degradation activity and a preparation method, a pharmaceutical composition and application thereof. The structure of the compound is as shown in the formula I. The compound can effectively degrade AR / AR-V7 proteins in vivo and in vitro, has a significant antitumor effect, has no obvious toxic side effects, and can be used for treating castration-resistant prostate cancer. The preparation method of the compound is simple and easy to operate, and is beneficial to structural expansion.

The invention provides application of linarin in preparation of a medicine for preventing or treating renal fibrosis, and belongs to the technical field of medical application. Researches find that the linarin can down-regulate the expression levels of YAP, CTGF and inflammatory factors IL-6, IL-1beta and TNF-alpha, and on the basis, the linarin or the pharmaceutically acceptable salt, ester or solvate thereof can be used for preparing the medicine for preventing and treating renal fibrosis caused by unilateral ureter obstruction or fibroblast hyperplasia. According to the present invention, the pharmaceutical composition can effectively inhibit the one-side ureter obstruction, can reverse the kidney injury caused by the one-side ureter obstruction, can improve the renal dysfunction caused by the one-side ureter obstruction, can provide the new drug selection for the application scenario requiring the down-regulation of the expression levels of YAP, CTGF and the like, and can provide the important guiding significance for the prevention and treatment of the renal fibrosis and the kidney injury, the renal dysfunction and other diseases caused by the renal fibrosis. And the linarin has no obvious toxic or side effect, is definite in curative effect, safe and controllable, and has a relatively high practical application value.

The invention provides application of ergothioneine to treatment of retinitis pigmentosa diseases, a model and a medicine. According to the application of the ergothioneine in preparing the food or the medicine for treating the retinitis pigmentosa, the retinitis pigmentosa can be treated, a model for treating the retinitis pigmentosa can be built, and the medicine with the treatment concentration of the ergothioneine can be prepared by utilizing the application. The traditional Chinese medicine composition has the beneficial effects that premature aging of irritable cells can be inhibited, and the retina function is protected.

The present application relates to the technical fields of genetic engineering and biological agents, and particularly relates to a hybrid peptide with immunoregulation and antioxidant functions, and a preparation method and application thereof.The polypeptide provided by the present application has both immunoregulation and antioxidant functions, and can significantly improve the immune function of the body and reduce the damage caused by immunosuppression to the body in normal or immunosuppressed states; and can enhance the antioxidant capacity of cells and the body; meanwhile, the polypeptide has the advantages of low cytotoxicity, high safety, simple preparation, low cost, and can be used as an ideal immunoregulator and antioxidant, and can be widely used in the fields of medicine, food, health care, feed, nutrition and the like of humans and animals, and has good application potential and value.

The present invention discloses a drug delivery nanosystem and method based on DNA origami and doxorubicin prodrug, belonging to the field of biomedical technology. In view of the abnormally high expression of NQO1 enzyme in many tumor cells, the present application synthesizes a target-activated anti-tumor prodrug based on doxorubicin as a model, and its pharmacological action can be activated by the NQO1 enzyme; at the same time, a rectangular DNA origami with good biocompatibility is used as a nanocarrier to efficiently carry the prodrug, thereby constructing an activatable precision drug delivery nanosystem. This prodrug-embedded rectangular DNA origami is conducive to reducing the toxic and side effects of anticancer drugs on normal human liver cells (L02 cells), and has a significant inhibitory effect on human breast cancer cells (MCF-7 cells) with high expression of NQO1 enzyme. This therapeutic nanosystem is expected to reduce the systemic toxicity of tumor drugs due to non-specificity, improve patients' compliance and quality of life, and provide an effective strategy for precise clinical intervention of tumors.