28 results about "Spatial learning" patented technology

The invention discloses a multi-frame photoacoustic image reconstruction method based on optical flow alignment and depth feature fusion. The method comprises the following steps: S1, obtaining photoacoustic signal data; s2, reconstructing a photoacoustic cross-sectional image; s3, performing optical flow calculation and image alignment; and S4, training the deep feature fusion network. According to the method, through optical flow motion correction and a potential space learning mechanism, space-time information and complementary features in the aligned multiple frames of images are dynamically integrated, complementary information in the multiple frames of images is adaptively fused, noise is suppressed, and finally reconstruction of high signal-to-noise ratio and high spatial resolution images of biological tissues is achieved. Experimental results show that the method can significantly improve image quality, recover image distortion and detail loss caused by motion and noise, and provide a new effective scheme for promoting robust clinical application of a photoacoustic imaging technology.

The invention provides a traditional Chinese medicine preparation for improving or treating cognitive impairment, and relates to the technical field of traditional Chinese medicine pharmacy, and the traditional Chinese medicine preparation is prepared from morinda officinalis, eclipta, semen boitae, fructus alpiniae oxyphyllae, bighead atractylodes rhizome, valerian, turmeric, rhizoma acori graminei, leech, rhizoma anemarrhenae, dendrobium officinale, endothelium corneum gigeriae galli, hematoxylon and honey-fried licorice root. The traditional Chinese medicine preparation shows remarkable neuroprotection and cognition improvement effects on the cell level and the animal level, in the cell level, the preparation can effectively resist Abeta1-42 induced cell damage, and the protection effect is achieved through multiple ways of improving the cell activity, enhancing the oxidation resistance, inhibiting neuroinflammation and the like; in animal experiments, the preparation can comprehensively improve cognitive impairment of APP / PS1 model mice, including relieving behavioral abnormality, improving spatial learning and memory ability, enhancing new object recognition ability, and effectively reducing deposition of A beta in hippocampus on a molecular level. The invention provides a new thought for improving or treating cognitive impairment.

This invention relates to the fields of aerospace vehicle overall design, and discloses a structured subspace learning-based solid rocket performance-cost analysis method, comprising: constructing a model sample dataset; constructing a structured sparse subspace feature selection model by combining a similarity graph matrix, and solving it to obtain an optimized row sparse orthogonal projection matrix, wherein the row index of the non-zero row corresponds to the feature parameter in the model sample as the selected cost driving factor; constructing a training sample dataset for a surrogate model; calculating the corresponding specific delivery cost as the output response based on the training samples, and training the surrogate model; for each cost driving factor, constructing a prediction sample dataset by random sampling; using a sequential quadratic programming method to find the optimal prediction sample in the prediction sample dataset, and determining the prediction sample with the minimum specific delivery cost as the final solid rocket design scheme.

The invention discloses a strain of lactobacillus acidophilus for treating chronic cerebral ischemia, which is preserved in the China Center for Type Culture Collection (CCTCC) and has the preservation number of CCTCC NO: M 20251505. Animal experiments show that the strain can reduce the death rate of chronic cerebral ischemia model mice and improve neurological impairment, motion coordination and spatial learning and memory ability of the chronic cerebral ischemia model mice. Mechanism research shows that the strain can increase histone acetylation and BDNF secretion by inhibiting the activity of astrocyte HDAC1, and meanwhile, can inhibit an NF-kappa B signal channel and reduce inflammatory factor release by activating a microglial cell GPR120 receptor, so that a neuroprotective effect is achieved through an'intestine-brain axis'. The invention provides a new candidate strain for the development of microbial preparations for preventing and / or treating chronic cerebral ischemia and related cognitive impairment.

The invention discloses application of lactobacillus rhamnosus to preparation of a product for improving cognitive impairment or neuroinflammation caused by chronic fatigue. The lactobacillus rhamnosus BD4047 is an edible safety strain, and can improve cognitive impairment of a chronic fatigue animal model by reversing short-term spatial learning memory ability and working memory ability; by improving the indole level, lowering the IL-33 level and balancing intestinal flora, the neuroinflammation of a chronic fatigue animal model is relieved, so that the lactobacillus rhamnosus BD4047 can be used as an active ingredient for developing functional foods such as fermented milk, lactobacillus beverages, probiotic powder, viable bacteria water, milk powder and cheese, and has large-scale production and market popularization prospects.

The invention discloses a nutritional composition for promoting brain development and application thereof, and relates to the technical field of biological medicines. The compound composition is selected from a composition A (melatonin + uridylic acid + inositol), a composition B (melatonin + uridylic acid) and a composition C (uridylic acid + inositol). Experiments prove that the combination B can significantly improve elevated anxiety behaviors and learning and memory ability caused by rhythm disorder, the combination C can significantly improve open field anxiety behaviors caused by rhythm disorder, and the combination A can significantly relieve anxiety behaviors (including elevated and open field) and spatial learning and memory ability disorder caused by rhythm disorder at the same time. The active components in the compound composition disclosed by the invention are remarkable in synergistic effect, high in safety and good in biocompatibility, and can be used for preparing medicines, food additives or feed additives for improving rhythm disorder related brain dysplasia.

The invention discloses application of Cacumen biotae-derived extracellular vesicles in preparation of drugs for treating anxiety, depression or insomnia. The EVs are separated and purified from cacumen biotae through a specific differential ultracentrifugation method, the EVs have a typical double-layer membrane structure, the average particle size is about 100 nm, about 1012 EVs can be extracted from each gram of cacumen biotae, and 62 volatile components are contained. Cacumen biotae EVs can be taken by PC12 cells, and corticosterone-induced neuron damage can be relieved; for chronic constraint stress model mice, anxiety behaviors and spatial learning and memory disorders can be improved, and central nervous inflammation can be inhibited; for chronic unpredictable mild stress model mice, the weight, the sucrose preference rate and the cognitive ability can be recovered, and the levels of 5-hydroxytryptamine and gamma-aminobutyric acid are increased; and for 4-chloro-DL-phenylalanine induced insomnia model mice, the sleep condition can be improved, the neurotransmitter level can be recovered, and the effect is equivalent to that of positive drugs such as citalopram, fluoxetine, diazepam and the like.

The invention relates to the field of bearing fault diagnosis, in particular to a variable-speed bearing fault diagnosis method based on physical feature guidance and dynamic tensor projection. The method comprises the following steps: acquiring a speed change historical time domain vibration signal when a bearing has a fault; an AWFE-CDSP-DDPL fault diagnosis model is constructed, and a fault diagnosis model is constructed; historical time domain vibration signals are divided into a training set and a test set by adopting a sliding window technology, and the AWFE-CDSP-DDPL fault diagnosis model is trained by using the training set; and obtaining a current variable speed time domain vibration signal of the bearing, and inputting the current variable speed time domain vibration signal into the trained AWFE-CDSP-DDPL fault diagnosis model to complete fault diagnosis. By means of the signal processing technology and the subspace learning method, the convolutional neural network is endowed with certain physical significance, meanwhile, the influence of the rotating speed is eliminated in network module construction, the bearing fault diagnosis precision under the variable speed condition is improved, and the research and economic production efficiency is improved.

The application relates to the technical field of animal learning ability testing, in particular to a ring-shaped runway for detecting the space learning and memory ability of small animals, which comprises a ring-shaped bottom plate, an inner baffle is arranged on one side of the inner ring of the ring-shaped bottom plate, an outer baffle is arranged on one side of the outer ring of the ring-shaped bottom plate, an experimental area for placing experimental objects is arranged on the ring-shaped bottom plate, and a water drinking area for water drinking of research objects is arranged on the ring-shaped bottom plate. The application has the beneficial effect that in the behavioral study of animal space memory, the application can reduce the information interference suffered by the research objects and can truly reflect the space memory of the research objects under normal conditions.

This invention discloses a remote sensing image wind turbine detection method based on attention mechanisms and feature alignment, relating to the fields of computer vision and remote sensing. The method includes inputting the acquired remote sensing wind turbine image into a deep residual network; sequentially passing the image through layers C2, C3, C4, and C5 of the deep residual network to extract feature maps at different scales; performing feature enhancement on the feature map extracted by layer C5 using a thresholding attention module with cross-spatial learning; inputting the features extracted by layers C3 and C4, and the features enhanced by layer C5 (using layer S2), into a feature pyramid after passing through a two-branch semantic flow alignment module; connecting each layer of the pyramid feature layers aligned by process S3 to a detection head, and finally outputting the detection result. This invention helps reduce background interference while preserving local information of the wind turbine, and utilizes spatial transformation techniques for precise alignment, thereby improving the accuracy of feature fusion and increasing the accuracy of the detection results.

The invention relates to the related technical field of vision regulation and control, in particular to a regulation and control device based on low-frequency flickering red light and a use method. The regulation and control device comprises a light source unit, a control unit, a carrier structure and an auxiliary module; the low-frequency flicker mode simulates the physiological rhythm of a visual system, the visual neural pathway and ciliary muscles are more easily activated compared with continuous light, the visual acuity improvement amplitude is improved by 30% or above compared with traditional red light equipment, and the adjustment lag is reduced by 25%; the nerve activation effect of the 40Hz frequency group is consistent with the PV neuron experiment of the Southern Science and Technology University, the space learning ability can be enhanced, the adaptation rate of sensitive people reaches 98% or above, and the short-time design of 3-5 minutes fits fragmentation time and adapts to home, travel and office scenes; the wavelength stability of the LED light source is + / -10nm, and the modular control design enables the consistency error of batch production to be 1t; 5%; aBS + PC materials are anti-falling and durable, heat dissipation holes are matched with aluminum cooling fins, it is ensured that the running temperature of equipment is smaller than or equal to 40 DEG C, and large-scale production and daily use reliability are both considered.

This invention relates to the field of computer vision technology, specifically disclosing a robust point cloud registration method and system based on block-aware serialization spatial learning. Addressing the problems of high computational complexity, noise sensitivity, and poor registration performance in partially overlapping scenes, existing methods employ a point cloud registration network comprising a segmentation and serialization module, a backbone network (encoder-decoder structure), and a dual-dominating head. The segmentation and serialization module divides the point cloud into multiple independent blocks and serializes them to maintain spatial locality; the encoder extracts multi-scale block-level features layer by layer; the decoder further aggregates contextual information; and the dual-dominating head predicts rotation quaternions and translation vectors respectively. Experiments show that this invention outperforms traditional iterative methods and existing deep learning models in registration accuracy, maintains stable performance in noisy environments and low-overlap scenes, and possesses high inference efficiency and low memory usage.

The invention discloses application of a soybean extracting solution to prevention and treatment of senescence-related cognitive impairment, and belongs to the technical field of application of plant extracts. A preparation method of the soybean extracting solution comprises the following steps that soybeans with the water content being 55% or above are flatly laid on a conveying belt, the soybeans are conveyed into extraction equipment disclosed by the patent ZL 201711472613.5 through the conveying belt, the soybeans sequentially pass through 11 plasma effect generator cracking reaction kettles, the reaction time of each plasma effect generator cracking reaction kettle is 40-60 seconds, and then the soybeans are extracted through the extraction equipment. The microwave power of the cracking reaction kettles of the first 10 plasma effect generators is 1-6 KW, and the microwave power of the cracking reaction kettles of the last plasma effect generator is 1-3 KW. The extracting solution is a natural plant liquid preparation and is high in safety. Experiments prove that the traditional Chinese medicine composition can significantly improve the working memory and spatial learning memory ability of mice with senescence-related cognitive impairment, regulate the neurotransmitter level, reduce oxidative stress and inflammatory response, and improve intestinal flora composition. The invention provides a brand-new, safe and effective natural medicine choice for preventing and treating senescence-related cognitive impairment, and can be used for preparing related medicines or foods.

The invention discloses a low-illumination image enhancement method based on mixed frequency domain-spatial domain double-branch Mama, and relates to the technical field of image processing and computer vision, and the method comprises the steps: constructing an image decomposer based on Retinex, generating an illumination prompt image, and obtaining a preliminary enhancement image; constructing a double-branch Mama module, extracting local textures by using a convolutional neural network branch, and capturing global illumination distribution by using a Mama branch; wherein the Mama branch is introduced into an attention state space module, an illumination prompt graph is used as prompt information to be integrated into a state equation, and context information is supplemented with low calculation cost; the features are converted to a frequency domain through a Fourier processing module, amplitude and phase components are enhanced respectively, and multi-domain feature fusion is carried out in combination with parallel spatial learning branches; and training based on the mixed loss function. According to the method, while the calculation overhead is reduced, collaborative optimization of global illumination recovery and local detail reconstruction is effectively realized, and the enhancement quality of the low-illumination image is remarkably improved.

The invention provides application of apoptin combined peptide to treatment of Alzheimer's disease. The apoptin combined peptide used in the invention has the following amino acid sequences: MetGlyArg, LysLysArg, Arg, GIn, Arg, Arg, LeuLysProProSerLysLysArgleArgleGlyleAlaGlyleThrLeuSerLeuArg, ProArg, Thr, AlaLysArg, ArgleArg, Leu and the like. The apoptin combined peptide provided by the invention has the following amino acid sequences: MetGlyArg, LysLysLysArg, Arg, Arg and Leu. Various animal model experiments prove that after the polypeptide drug is administered through intravenous injection (with the dosage of 1mg / kg to 3mg / kg), cognitive impairment, spatial learning and memory ability of model animals with Alzheimer's disease, vascular dementia and senile dementia can be remarkably improved, and the treatment effect is superior to that of donepezil. The action mechanism comprises reduction of oxidative damage, inhibition of APP and BACE1 pathological protein expression, increase of neuron number and nissl body content, inhibition of cell apoptosis and the like. The polypeptide medicine is high in safety and remarkable in curative effect, and a new effective medicine is provided for treating the Alzheimer's disease.

The application discloses a compound essential oil composition for improving concentration and enhancing memory and application thereof, and belongs to the technical field of daily-use chemicals. The composition is prepared from rosemary leaf oil, musk grass oil, hot mint oil, blue eucalyptus leaf oil, white orchid leaf oil, methyl 2, 4-dihydroxy-3- (2-hydroxypropyl) benzoate, lemon peel oil, white orchid oil, calamus root extract and angelica root extract according to specific weight percentages, and is added and homogenized in steps according to the order of component viscosity and volatility. Animal experiments prove that the composition can significantly improve the space learning and memory ability of a cognitive impairment model mouse, and the escape latency and invalid exploration behavior of the mouse are significantly reduced. Human efficacy tests show that single sniffing can improve the mean value of the power spectrum density of the brain concentration related beta wave, shorten the Stroop test reaction time, reduce the error rate, and significantly improve the concentration ability. The composition can be prepared into aromatherapy liquid, massage paste and other products, and is used for safely and quickly improving concentration and cognitive function, and has significant application value.

The invention discloses an application of white datura in preparation of a medicine for preventing and treating cerebral ischemia-reperfusion injury. The invention proposes and verifies that white datura can effectively prevent and treat ischemia reperfusion injury for the first time, including greatly reducing the volume of cerebral infarction caused by cerebral ischemia reperfusion; meanwhile, the neurological function impairment symptoms such as motor coordination and balance ability reduction, spatial learning and reference memory impairment and depression-like behaviors caused by cerebral ischemia reperfusion are remarkably improved, and a natural medicine with great application potential is provided for mechanism research, prevention and treatment of cerebral ischemia reperfusion injury.

The invention discloses a calculation method and device for time sequence operation and maintenance early warning based on a pipe network spatial topological structure, belongs to the technical field of sewage pipe networks, and solves the problems that an existing pipe network early warning method is low in prediction precision and is difficult to capture time-space dynamics at the same time. According to the method, directed hydraulic association between monitoring nodes is dynamically deduced by using a time-space diagram neural network, and time-space convolution calculation is synchronously performed, so that high-precision time sequence prediction of the global liquid level in a period of time in the future is realized, a potential time-space dynamic relationship in historical monitoring data is fully excavated, and the accuracy of time sequence prediction is improved. And by fusing physical prior information and a federal learning data complementation mechanism, the reliability and the spatial learning ability of the prediction model are remarkably improved. And finally, an operation and maintenance report containing over-limit early warning and a topological correlation-based key attention node list is generated, and a clear basis is provided for accurate troubleshooting and efficient decision making of operation and maintenance personnel, so that the maintenance and decision making cost of a pipe network system is remarkably reduced, and the management level and efficiency of water resources are improved.

The invention provides a neuroprotective effect of DIRAS1 on Alzheimer's disease (AD), and belongs to the technical field of biological medicine. The invention provides application of a reagent for overexpressing a DIRAS1 gene in preparation of a medicine for preventing and / or treating AD by taking the DIRAS1 gene as a therapeutic target of AD. The treatment of a model mouse in the embodiment finds that the DIRAS1 gene is over-expressed in the brain of the AD mouse, and the cognitive function detection finds that the recognition memory, the working memory and the long-term spatial learning memory of the AD mouse can be remarkably improved; morphological and molecular biological detection finds that deposition of A beta and excessive phosphorylation of Tau protein are reduced, and Golgi staining and western blot detection finds that damage to a synaptic structure is reduced and expression of synaptic related protein is increased. Therefore, the cognitive function, pathological characteristics and synaptic plasticity of AD mice can be improved by a method of overexpressing the DIRAS1 gene.

This invention provides an application of Pulsatilla Decoction in the preparation of drugs for treating cognitive impairment. It significantly improves spatial learning and memory, recognition memory, and anxiety-depression-like behaviors in model mice, while increasing cerebral blood flow, reducing hippocampal neuronal damage, and effectively regulating the levels of neurotransmitters such as tryptophan, 5-HT, dopamine, and GABA in the brain. This formula exerts a central protective effect while alleviating intestinal inflammation, demonstrating the dual regulatory advantage of the gut-brain axis. Furthermore, its active ingredient, Pulsatilla saponin B4, also has the effect of improving cognitive function. This invention provides a scientific basis for the "repurposing" of classic formulas, possessing clear efficacy, good safety, and mature preparation technology, and has good prospects for clinical translation.

The application provides a circular RNA circ_0004801 and application thereof in Alzheimer's disease treatment; a nucleotide sequence of the circular RNA circ_0004801 is shown as SEQ ID NO:1. Expression of the circular RNA circ_0004801 in hippocampus tissue of AD mice is significantly up-regulated, the circular RNA circ_0004801 acts as a "sponge" of miR-7688-5p, and plays a role by regulating TTBK1 expression and tau phosphorylation level. Knocking down the circular RNA circ_0004801 can obviously improve spatial learning and memory of 3xTg mice, significantly reduce tau protein phosphorylation level in hippocampus and NFTs density in hippocampus DG region. Therefore, the circular RNA circ_0004801 and miR-7688-5p can be used as a new target for treating AD. The application first finds that the circular RNA circ_0004801 regulates TTBK1 through a ceRNA mechanism, thereby driving tau hyperphosphorylation, and provides a new molecular target for early intervention treatment of AD based on circRNA and miRNA.

The invention discloses an application of luteolin in preparation of a medicine for improving cognitive impairment induced by corticosterone (Cort), and relates to a medicine for improving cognitive impairment induced by corticosterone (Cort). By constructing a mouse cognitive impairment model induced by chronic Cort, research proves that the luteolin can remarkably improve the spatial learning and memory ability of a model mouse. The action mechanism is related to a multi-target synergistic effect, and mainly comprises the steps of relieving oxidative stress injury, inhibiting hippocampal neuron apoptosis, adjusting the autophagy level and enhancing synaptic plasticity. The new application and multi-mechanism synergistic effect of the luteolin for improving the Cort-induced cognitive impairment are defined, and a new technical scheme is provided for developing safe and effective cognitive impairment treatment medicines.

Pharmacological or genetic inactivation of MAGL reduces neuroinflammation and neuropathology in animal models of AD. However, global inactivation of MAGL induces functional tolerance of CB IR, which reduces the effectiveness of pharmacotherapies. Evidence has shown that selective inactivation of MAGL in astrocytes, but not in neurons, reduces neuropathology and synaptic and cognitive impairments in TBI. In particular, results showed that inactivation of astrocytic MAGL attenuates AD neuropathology and prevents deterioration in LTP, spatial learning and memory in AD animals. This shows that neuroprotective effects of global MAGL inactivation largely result from limiting 2-AG degradation in astrocytes, rather than in neurons. Therefore, selective inactivation of astrocytic MAGL provides a better therapeutic outcome for AD, as this greatly minimizes the potential adverse effects resulting from global inactivation-induced disruption of 2-AG degradation in neurons and in other peripheral tissues. To this end, an AAV-mediated gene silencing approach to knock MAGL selectively in astrocytes is presented.

The application provides a traditional Chinese medicine preparation for improving or treating cognitive impairment, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from Radix Morindae Officinalis, Herba Hyperici Japonici, Platycladi Seed, Fructus Evodiae, Rhizoma Atractylodis Macrocephalae, Valeriana, Curcuma Longa, Rhizoma Acori Tatarinowii, Hirudo, Rhizoma Anemarrhenae, Dendrobium officinale, Gigeriae Cacumen, and Radix Pini. The traditional Chinese medicine preparation in the application shows significant neuroprotective and cognitive improvement effects at the cell and animal levels: at the cell level, the preparation can effectively resist A 1‑42 induced cell damage, and plays a protective role through multiple pathways such as improving cell viability, enhancing antioxidant capacity and inhibiting neuroinflammation; in animal experiments, the preparation can comprehensively improve the cognitive dysfunction of APP / PS1 model mice, including relieving behavioral abnormalities, improving spatial learning and memory ability, enhancing new object recognition ability, and effectively reducing Aβ deposition in hippocampal tissue at the molecular level. The application provides a new idea for improving or treating cognitive impairment.

This invention discloses the application of Polygonatum odoratum carbon quantum dots (PC-CQDs) in the preparation of drugs for treating vascular dementia, belonging to the field of pharmaceutical technology. This invention is the first to apply PC-CQDs to the treatment of vascular dementia. Morris water maze test and hippocampal histopathological analysis confirmed that PC-CQDs can significantly improve spatial learning and memory abilities in VaD rats, protect hippocampal neurons, and exhibit good biocompatibility. This invention provides a new drug option for the treatment of vascular dementia, possessing significant clinical application value and broad market prospects.

The present disclosure relates to a chemical compound having the general formula (I):wherein R1 is a phenyl group and R2 is a meta-substituted phenyl group; and RTA is a substituted or unsubstituted thiazole ring. The disclosure also relates to said compound according to formula (I), in particular in its diastereomerically pure or enriched form, for use in therapy, in particular for treating and / or preventing age-related cognitive decline. Further, the disclosure relates to said compound according to formula (I) for use in improving cognitive functions, in particular for use in improving the spatial learning capabilities in human individuals. And, disclosure also relates to said compound according to formula (I) for use in the treatment and / or prevention of alcohol addiction, nicotine addiction and / or drug addiction, in particular cocaine and / or metamphetamine addiction.

The invention is applicable to the technical field of biological medicines, and provides application of ginsenoside CK in preparation of a medicine for preventing or treating Alzheimer's disease. Experiments prove that the ginsenoside CK can significantly improve the spatial learning and memory ability of AD model animals and relieve anxiety behaviors of the AD model animals; the deposition of brain tissue hippocampal Abeta (1-42) protein is effectively reduced, and the key molecular pathology of AD is relieved from the source; the level of key inflammatory factors in brain tissues and serum is strongly inhibited, and AD-related chronic neuroinflammation is controlled; according to the present invention, the CK has the specific protection effect on the hippocampal neuron structure, such that the CK can be adopted as the multi-target treatment agent so as to prevent and / or treat the Alzheimer's disease.

This invention discloses a concentration-enhancing chair, a study desk, and their kit system, belonging to the interdisciplinary fields of ergonomics, acoustic noise reduction, mental health support, and lighting technology. The system includes a concentration-enhancing chair system and a concentration-enhancing study desk system. The chair employs a U-shaped three-layer composite noise-reduction cavity with lateral peripheral light shielding and independently adjustable ergonomic support, achieving noise reduction and lateral visual shielding in the 500Hz–2000Hz interference frequency band, forming a semi-enclosed psychologically stable space. The study desk features a three-sided enclosed visual peripheral light shielding and noise reduction structure, combined with a height- and angle-adjustable eye-protecting light source. This invention eliminates attention interference from five dimensions: noise, vision, optics, psychology, and tactile sensation. It can be modularly manufactured independently or used in combination, suitable for children and adolescents aged 6–18, and applicable to highly focused scenarios such as learning and reading. The technical solution of this invention is supported by authoritative research, and the cited research conclusions are designed for "learning scenarios, concentration enhancement, and adolescent suitability," perfectly corresponding to the application scenarios of this invention.