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Application of polygala alkaline hydrolysis product composition in preparation of anti-senile dementia medicine

A composition and age-related technology, which can be used in the direction of drug combination, application, food preparation, etc., and can solve the problem of disappearance of hemolysis

Inactive Publication Date: 2012-08-29
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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Problems solved by technology

Through the structural analysis of more than 90 polygala saponins published in the public, it is found that the polygala saponins are oleanane-type pentacyclic triterpenes, the 3-position hydroxyl forms a glycoside bond with glucose, and the 28-position carboxyl forms an ester bond with sugar. This type of saponin generally has a hemolytic effect, but when the 28-position ester bond is hydrolyzed by alkali, the hemolytic effect disappears

Method used

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Embodiment Construction

[0015] specific implementation plan

[0016] 1 Preparation of the composition

[0017] Method 1: Weigh 1 kg of Polygala medicinal material, cut into sections, reflux extraction with 8 times the volume of 70% ethanol for 3 times, each time for 4 hours, filter, combine, recover the solvent under reduced pressure, and evaporate to dryness to obtain 380 g of Polygala extract. After dissolving Polygala extract with distilled water, perform column chromatography with D101 macroporous resin, first elute with 40% ethanol until the effluent is colorless, and discard the eluent; color, the solvent was recovered under reduced pressure, and evaporated to dryness to obtain 160 g of total saponins of polygala. Put the total saponins of polygala in 3000 mL of NaOH solution with pH=10, heat at 80°C for 8 hours, let it cool, and adjust the pH value to 4-5 with hydrochloric acid. The alkaline hydrolysis solution after acidification was subjected to column chromatography with D101 macroporous ...

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Abstract

The invention provides an application of polygala alkaline hydrolysis product composition in preparation of an anti-senile dementia medicine. The polygala alkaline hydrolysis product composition comprises the following main components by weight percentage: 25-38% of tenuifolin, 10 to 25% of fallaxsaponin A, 12 to 25% of 3, 4, 5-trimethoxycinnamic acid (TMCA) and 5-15% of p-methoxycinnamic acid (PMCA). The polygala alkaline hydrolysis product composition can obviously improve learning and memory impairment of a C57 mouse caused by hippocampal injection of Alpha Beta 25-35 and can obviously improve the spatial learning and memory capability of a C57 mouse model suffering from the learning and memory impairment caused by scopolamine, with an effect superior to that of a positive medicine, as well as can obviously improve the spatial learning and memory capability and the passive avoiding capability of a rapidly-aging C57 mouse model suffering from the learning and memory impairment.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and mainly relates to the application of the alkali hydrolyzate of the traditional Chinese medicine polygala and the extracts of plants of the same genus in anti-senile dementia medicine. technical background [0002] Alzheimer's disease (Alzheimer's Disease, AD) often occurs in the elderly and pre-senile, also known as Alzheimer's disease, is a neurodegenerative disease characterized by progressive cognitive dysfunction. With the aging of the population, AD has become one of the major diseases that seriously threaten the life and health of the elderly after cardiovascular diseases and tumors. At present, the pathogenesis of AD is still unclear, and the loss of cholinergic neurons and free radical oxidative damage may be the main pathogenesis. The theory of cholinergic damage shows that the level of neurotransmitter acetylcholine in the brain of AD patients is significantly reduced, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A23L1/29A61P25/28A23L33/00
Inventor 潘瑞乐刘新民常琪徐淑萍王君王力为
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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