60 results about "Memory impairment" patented technology

The invention discloses an active peptide capable of improving cognitive impairment as well as a preparation method and application of the active peptide. The amino acid sequence of the active peptide is shown as SEQ ID NO: 1, 2, 3, 4, 5 or 6. The invention aims to provide a novel active peptide as well as a preparation method and application thereof aiming at the problems of limited means and unstable effect of improving cognitive impairment in the prior art, the active peptide prepared by the invention can improve the problems of learning and memory impairment and cognitive function decline to a certain extent, enriches technical approaches for improving cognitive impairment, and has a wide application prospect. And a new application choice is provided for related fields.

Methods are provided for determining a memory impairment probability. The method comprises receiving one or more audio recordings of an interaction by a user with a computing device during an assessment; extracting acoustic and speech timing features from the one or more audio recordings; applying a machine learning model to the acoustic and speech timing features to generate a memory impairment probability for the user; and providing a clinical decision support recommendation for a provider based on the memory impairment probability.

The present invention relates to a use of a methylated peptide as a therapeutic agent for degenerative brain diseases. Specifically, it has been confirmed that the methylated peptide according to the present invention exhibits improved solubility, bioavailability, phagocytosis by microglia, and anti-inflammatory efficacy compared to a conventional unmodified peptide, and exhibits excellent amyloid beta reduction efficacy compared to a conventional unmodified peptide in an animal model of degenerative brain diseases. Therefore, the methylated peptide according to the present invention can be usefully used as an active ingredient of a composition for preventing or treating degenerative brain diseases and cognitive impairment, learning disability, or memory impairment associated therewith.

The disclosure relates to the use of phosphodiesterase 1 (PDE1) inhibitors for preventing or treating chemobrain, e.g., inhibiting or mitigating one or more symptoms of chemobrain, e.g., feeling of mental fogginess, deficit in attention, disorganized behavior or thinking, confusion, impaired concentration, difficulty finding the right word, difficulty learning new skills, difficulty multitasking, memory impairment (e.g., short-term memory problems, long-term memory problems, impaired verbal memory, impaired visual memory), and / or fatigue.

Provided are compositions and methods for memory enhancement, including recovery of memory impairment. The compositions and methods relate to mannose-6-phosphate and derivatives of mannose-6-phosphate. The methods relate to administration of M6P or derivatives thereof to individuals in whom memory enhancement is desired.

The invention discloses calf animal coccus PD13 for improving Alzheimer's disease and application of the calf animal coccus PD13, and relates to the technical field of biology. Experiments prove that in an Alzheimer's disease model mouse induced by injecting A beta oligomer into the brain, the Azococcus calvus PD13 can improve spatial learning and memory disorder and autonomous exploration ability of the AD model mouse and relieve damage to neurons in a hippocampal region of the Alzheimer's disease model mouse, so that the effect of protecting the neurons is achieved, and the Azococcus calvus PD13 can be used for preparing a medicine for treating the Alzheimer's disease. According to the present invention, with the application of the animal coccus calves, the content of glutathione in mouse serum and the enzyme activity of superoxide dismutase are increased, and the content of malondialdehyde is reduced, such that the animal coccus calves provides good prevention and treatment effects on the Alzheimer's disease, and the new approach is provided for developing the Alzheimer's disease-related drugs.

This invention discloses the application of MYDGF in the prevention and treatment of memory impairment and related diseases. This invention discloses that MYDGF shows significant differences in individuals with memory impairment. After administration of MYDGF, memory impairment can be prevented and memory impairment can be prevented and the death of newly generated neurons can be stopped.

The present invention provides a use of lactoferrin in combination with ergothioneine in the preparation of a drug for preventing and / or treating Alzheimer's disease. Compared with the use of lactoferrin or ergothioneine alone, in the present invention, the combined use of lactoferrin and ergothioneine at a specific ratio as an active pharmaceutical ingredient can reduce cell damage caused by Aβ25-35, reduce the expression of a p-Tau protein, lower the oxidative stress level and regulate apoptosis, alleviate memory impairment and cognitive dysfunction, and can reduce Aβ deposition in mouse plasma.

The invention relates to a construction method and application of a rapid aging animal model. According to the invention, the C5a protein is injected into the hippocampus of an animal in a brain stereotactic manner, so that the rapid aging animal model is successfully constructed. The rapid aging animal model construction method provided by the invention has high repeatability, and the rapid aging animal model can be efficiently and stably prepared; moreover, the rapid aging animal model constructed according to the method disclosed by the invention shows obvious and stable learning and memory disorder and aging-related phenotypes, including reduction of learning and memory ability, increase of aging marker level, damage of synapse-related protein and the like, has high representativeness, and can be applied to the rapid aging animal model. Therefore, the method is not only suitable for pathological mechanism research of senescence and related diseases or symptoms, but also provides a powerful tool for drug development of senescence related diseases or symptoms (such as cognitive hypofunction caused by senescence), and shows a good industrial application prospect.

1. Name of the Design Product: Dynamic Graphical User Interface for Neurorehabilitation Training of Display Screen Panel. 2. Use of the Design Product: Used for displaying graphical user interface and interaction. 3. Design Key Points of the Design Product: Lie in the interface content of the graphical user interface on the screen. 4. Picture or Photo that Best Illustrates the Design Key Points: Front View. 5. The display screen panel is of conventional design, so the left view, right view, top view, bottom view are omitted; the rear view is omitted. 6. Use of the Graphical User Interface: Used for the rehabilitation training of patients with memory disorders. 7. Human-Machine Interaction Method of the Graphical User Interface: Clicking, voice prompts, and blood oxygen data of the trainee. 8. Explanation of the Changing States of the Graphical User Interface: The front view is the welcome interface for neurorehabilitation training, with a voice prompt "Training items are being loaded, please wait a moment" and enters the interface changing state diagram 1, which is the training item loading interface; the interface changing state diagram 2 is the interface when the item loading is about to be completed; the interface changing state diagram 3 is the resting state interface during the training process of the trainee after the loading of the item is completed; the interface changing state diagram 4 is the interface ending the resting state stage, and a voice prompt: "Please try to remember the colored graphics that appear on the carriage" is given, and at the same time as the voice prompt, it enters the interface changing state diagram 5; the interface changing state diagram 5 is the teaching training stage interface during the training process of the trainee, the interface changing state diagram 6 is the animation interface at the end of the teaching training stage of the trainee; the interface changing state diagram 7 is the animation interface at the end of the teaching training stage of the trainee; from the interface changing state diagram 3 to the interface changing state diagram 4 is the resting state stage during the training process; from the interface changing state diagram 5 to the interface changing state diagram 7 is the teaching training stage during the training process, and while testing from the interface changing state diagram 3 to the interface changing state diagram 7, the blood oxygen concentration of the trainee is determined and then enters the interface changing state diagram 8, which is the interface showing the start screen of the training; the interface changing state diagrams 9-13 are the interfaces of the training questions; in the interface changing state diagrams 9 to 13, the vines on the roof of the carriage become longer or shorter according to the blood oxygen concentration of the trainee; the interface changing state diagram 13 is the last question, and after the end, it enters the interface changing state diagram 14, and at the same time a voice prompt: "Training ended". 9. Other Situations Requiring Explanation: Other Explanation: The display screen panel and the displayed graphical user interface are applied to computers, laptops, tablets, and mobile phones. The blood oxygen concentration data is received through a communication connection in the near-infrared data acquisition module.

The invention relates to the technical field of application of natural active substances, in particular to application of octyl gallate in preparation of products for strengthening brain and improving intelligence. According to the application of the octyl gallate in preparation of the products for strengthening the brain and improving intelligence, the oxidative stress level of brain tissue and neuroinflammation response can be effectively relieved, and therefore learning and memory impairment and cognitive function decline caused by chronic sleep interference are improved. The invention finds that the octyl gallate as a polyphenol active substance has good intelligence-promoting and health-care effects, and can be used for preparing health-care foods, functional foods or nutritional supplements for improving learning memory and relieving cognitive dysfunction within a certain dosage range. The octyl gallate is clear in raw material source, can be obtained through natural extraction or chemical synthesis, and has the advantages of being high in safety, wide in application range, remarkable in economic value and the like.

This invention discloses a method for constructing a zebrafish nervous system inflammation model and its applications, belonging to the field of animal neuroinflammation model technology. The method provided by this invention can construct a zebrafish nervous system inflammation model and has the advantages of short modeling time, high success rate, and simplicity. The zebrafish nervous system inflammation model constructed by this invention can be used to develop a drug screening platform for the effects of neuroinflammation, neurodegenerative diseases, and memory impairment, screening for potentially effective drugs by observing behavioral changes in zebrafish. It can also utilize the genetic background of zebrafish to study the molecular mechanisms of memory impairment, providing a theoretical basis for future treatments. It has applications in medicine, drug development, and the screening of natural active ingredients.

Provided are a pharmaceutical composition for preventing and / or treating neurodegenerative diseases and use thereof. The pharmaceutical composition comprises rivastigmine, liraglutide, and derivatives thereof; the pharmaceutical composition further comprises a sustained-release system, the sustained-release system can interact with the rivastigmine, the liraglutide, and the derivatives thereof to form a copolymer that enables sustained drug release, and the sustained-release system is a triblock hydrogel sustained-release system. The combination of the liraglutide and the rivastigmine can ameliorate the learning and memory impairments associated with Alzheimer's disease, with the effect superior to monotherapy and exhibiting a synergistic effect.

The invention provides a pharmaceutical composition for preventing and treating senile cognitive impairment with bipolar affective disorder as well as a preparation method and application of the pharmaceutical composition, and belongs to the technical field of medicines. The pharmaceutical composition prepared by mixing volatile oil separated from rhizoma acori graminei and ligusticum wallichii and aqueous extracts separated from rhizoma acori graminei, ligusticum wallichii, astragalus membranaceus and polygala tenuifolia is rich in volatile oil and various water-soluble active ingredients. Based on the characteristics of promoting nerve cell growth and memory damage repair, the invention also provides application of the pharmaceutical composition in preparation of medicines for preventing and / or treating senile cognitive impairment and / or accompanied bipolar affective disorder.

The invention discloses bifidobacterium pseudolongum LCPJ07 and application thereof in production of sialic acid and improvement of senescence or diabetes related cognitive impairment, and belongs to the technical field of functional microorganisms. The strain can be used for improving cognitive and memory impairment of mice with Alzheimer's disease, and the strain or a preparation containing the strain can enrich sialic acid, improve behavior change of the mice with cognitive impairment induced by senescence or diabetes, regulate brain region inflammation unbalance of the mice with cognitive impairment, effectively remodel the structure of intestinal flora of the mice with cognitive impairment and improve the immunity of the mice with cognitive impairment. The relative abundance of intestinal beneficial bacteria is improved. The bifidobacterium pseudolongum LCPJ07 disclosed by the invention can be used for preparing diets or medicines for preventing or treating different types of cognitive impairments, and has a very wide application prospect.

The invention discloses a cognitive memory imagination combined training device for a patient with cognitive impairment, relates to the technical field of cognitive impairment training equipment, and provides the following scheme that the cognitive memory imagination combined training device comprises a patient moving carrier which is divided into a moving base located at the bottom and a patient deck chair located at the top; a training device is arranged on the left side of the patient moving carrier. According to the technical scheme, the patient moving carrier is arranged, so that the patient with learning and memory impairment and companied with pathological symptoms can move normally, in the moving process of the patient, the patient can stop at any time and carry out cognitive memory imagination training, the camera on the front side is used for recognizing an object, and the patient moving carrier is used for carrying out cognitive memory imagination training. The method comprises the following steps: acquiring an object, training a patient to understand the object in a manner of image presentation and sound broadcast on a main screen, recording sound and images of family members of the patient on an auxiliary screen, and guiding the patient to pass cognitive training at the family members, so that the patient can better accept training items.

The invention discloses Weissella sinus PD13 for improving Alzheimer's disease and application of the Weissella sinus PD13, and relates to the technical field of biological medicine. Experiments prove that Weissella cibaria PD13 can improve spatial learning and memory impairment and autonomous exploration ability of AD model mice in Alzheimer's disease model mice induced by brain injection of A beta oligomer, and alleviate damage of neurons in hippocampal regions of the Alzheimer's disease model mice, so that the effect of protecting neurons is achieved, and the Weissella cibaria PD13 can be used for preparing drugs for treating Alzheimer's disease. According to the present invention, the Weissella cibaricola can effectively prevent and treat the Alzheimer's disease, increase the glutathione content and the superoxide dismutase enzyme activity of the mouse serum, and reduce the malondialdehyde content, such that the Weissella cibaricola has good prevention and treatment effects on the Alzheimer's disease, and the new approach is provided for developing the Alzheimer's disease-related drugs.

The present invention relates to a composition for the prevention, improvement, or treatment of memory impairment or cognitive impairment comprising a black pepper (Piper nigrum) extract, and more specifically, to a composition for the prevention, improvement, or treatment of memory impairment or cognitive impairment induced by scopolamine comprising a black pepper 70% (v / v) ethanol extract as an active ingredient. It was confirmed that the black pepper extract of the present invention, particularly the black pepper ethanol extract, contains a high content of piperine and effectively inhibits the inflammatory response induced in LPS-stimulated microglia without cytotoxicity compared to Indian pepper (Piper longum) or black pepper methanol extract. Furthermore, the black pepper extract of the present invention showed memory-enhancing effects in the Y-maze test and passive avoidance test using mice with memory impairment induced by scopolamine, and since the BDNF-CREB pathway activation effect was confirmed, it can be usefully utilized as a composition for the prevention, improvement, or treatment of memory impairment or cognitive impairment induced by scopolamine.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a traditional Chinese medicine nasal spray for efficiently and safely treating post-stroke mild cognitive impairment as well as a preparation method and application of the traditional Chinese medicine composition and the traditional Chinese medicine nasal spray. According to the traditional Chinese medicine composition, all the medicines are synergistic to achieve the effects of tonifying the kidney, replenishing essence, reducing phlegm, inducing resuscitation, dredging collaterals and restoring consciousness together, the pathogenesis of'deficiency in root and excess in superficies' after stroke is considered, and the symptoms of cognitive decline, slow response, dysmnesia and the like caused by brain marrow malnutrition and phlegm stasis orifice blocking can be improved. The traditional Chinese medicine nasal spray is rapidly absorbed through nasal mucosa, improves the intracerebral microenvironment in a targeted manner, remarkably improves the intracerebral concentration of the medicine through a nasal cavity-brain targeted delivery technology in combination with the permeation enhancing effect of borneol and mint, is suitable for patients needing to improve the cognitive function, and provides an innovative solution for post-stroke rehabilitation.

The invention discloses application of bifidobacterium longum in preparation of a product for relieving cognitive impairment caused by methylmalonemia, and belongs to the technical field of microorganisms. The Bifidobacterium longum CCFM752 is preserved in the Guangdong Province Microbial Culture Collection Center, the preservation number is GDMCC (China General Microbiological Culture Collection Center) No.61157, and the preservation date is August 21, 2020. The Bifidobacterium longum CCFM752 disclosed by the invention has the advantages that the Bifidobacterium longum CCFM752 can be used for preparing the biological feed additive; the effect of the bifidobacterium longum CCFM752 for relieving the cognitive impairment of the MMA disease is comprehensively evaluated through an MMA model rat, and the effect is specifically reflected as follows: (a) the cognitive and memory impairment is relieved; (b) relieving activation of small glial cells in the hippocampus; (c) reducing the malondialdehyde level in serum and / or tissue to a certain extent; and (d) improving the level of glutathione peroxidase in serum and / or tissues to a certain extent.

The invention discloses an application of lactobacillus plantarum in preparation of a product for relieving individual oxidative stress and cognitive impairment caused by methylmalonic acidmia, the lactobacillus plantarum is preserved in Guangdong Microbial Culture Collection Center, the preservation number is GDMCC No.61163, and the preservation date is August 21, 2020. The lactobacillus plantarum can be applied to preparation of a product for relieving individual oxidative stress and cognitive impairment caused by methylmalonic acidmia. The relieving effect of lactobacillus plantarum CCFM1149 intervention on oxidative damage and cognitive impairment caused by MMA diseases is comprehensively evaluated through MMA model rats, and the relieving effect is specifically reflected as follows: (a) cognitive and memory impairment is relieved; (b) relieving activation of small glial cells in the hippocampus; (c) reducing malondialdehyde levels in serum and / or tissue; and (d) increasing the level of glutathione peroxidase in serum and / or tissues.

The present invention relates to: a composition for improving cognitive function, comprising a natural extract complex; and use thereof. According to an embodiment of the present invention, a composition for improving cognitive function or memory, comprising one or more selected from the group consisting of a Perilla frutescens var. acuta kudo extract, a Moringa oleifera extract, and a Phyllanthus emblica extract, exhibits few side effects due to being based on natural substances, is readily available, and provides an excellent cognitive function improvement effect while being cost-effective. Therefore, the composition can be effectively used for the prevention, amelioration or treatment of diseases associated with cognitive or memory impairment.

A construction method for an experimental animal learning and memory impairment model, comprising: individually housing a CD-1 mouse to allow the CD-1 mouse to develop territorial awareness; subjecting an experimental mouse and the CD-1 mouse to physical confrontation in a cage for a preset duration; and once the experimental mouse has developed acute violent stress, placing the experimental mouse into a Skinner box apparatus to perform a learning ability test, after a preset duration, performing a memory ability test, and after the tests, obtaining the experimental animal learning and memory impairment model. The method assesses animal learning and memory abilities by means of a Skinner box, expands assessment means related to learning and memory, and provides new data support for the construction and assessment of an animal model involving learning and memory impairment induced by acute violent stress.

This application pertains to a compound of Formula (I), Formula (I'), Formula (I") or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein X, R1, R2, R3, R5, R6, and R7 are as defined herein, and uses of such compounds in methods of treating neurodegenerative diseases, neurodevelopmental disorders, and age-related memory impairment.

The application provides a silver fungus vessel-activating and brain-strengthening granule, a preparation method and application, and comprises the following components in parts by weight: wine jujube 10-15 parts, ginkgo leaves 10-15 parts, female privet fruit 8-12 parts, salvia miltiorrhiza 8-12 parts, alocasia 5-7 parts, eucommia ulmoides 8-12 parts, poria cocos 8-12 parts, Uncaria 8-10 parts, Gastrodia 8-12 parts, fried hawthorn 5-7 parts, turmeric 8-10 parts, and chuanxiong 5-7 parts. The silver fungus vessel-activating and brain-strengthening granule has the effect of improving memory impairment of vascular dementia.

A cognitive dysfunction diagnosis device (1) includes: an acquisition unit (41) that acquires a distribution map that shows a distribution of a viewpoint of a subject with respect to a diagnosis image; and a diagnosis unit (39) that diagnoses the diagnosis image that includes a first image and an evaluation image in chronological order, the first image has a first region that includes a memorization image that is visually highlighted and a plurality of second regions that include a general image that is not highlighted, the evaluation image has a third region and the plurality of second regions, the third region includes an evaluation image, the evaluation image is an image that is similar to the memorization image and is displayed without visual highlighting at the same position as the memorization image, the diagnosis unit (39) calculates a fixation rate of the third region in the distribution map with respect to the evaluation image, and in a case where the fixation rate is lower than a threshold value, it is diagnosed that there is a suspicion of memory impairment.

The invention discloses application of fenofibrate to improvement of learning and memory ability decline caused by a microgravity effect. Experiments show that fenofibrate can effectively improve the reduction of the spatial memory ability of a mouse with a suspended tail. Experimental results show that fenofibrate has the value of being developed into drugs for preventing and treating related learning and memory ability decline.

The application belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine supramolecular nanoparticle, which is prepared from Uncaria as a raw medicinal material, is extracted by heating reflux with 68-72% ethanol, is filtered, and is dried after being dialyzed after being dispersed in pure water, centrifuged, resuspended, and centrifuged again. The traditional Chinese medicine supramolecular nanoparticle has uniform particle size, a narrow particle size distribution, and high stability. The nanoparticle has obvious anti-nerve oxidation and obvious nerve protection effects according to in-vitro cell activity detection. The nanoparticle has good in-vivo nerve protection effect, can improve memory impairment and cognitive impairment, and can prevent hippocampal neuron reduction. Compared with Uncaria effective parts, the effective administration dose of the traditional Chinese medicine supramolecular nanoparticle is obviously reduced. The application also discloses a use of the traditional Chinese medicine supramolecular nanoparticle in preparation of a medicine for treating nervous system diseases.

The application discloses a target strategy and a drug intervention method for improving Primrose syndrome, and belongs to the technical field of biological medicine. The experiment proves that Momordin Ic can significantly improve the SUMO level of ZBTB20 in vitro cells or Primrose syndrome (PS) mice, can effectively improve the defects of reduced neuron dendritic branching in the hippocampal CA1 region of the PS mice in pathology, can enhance the complexity, and can improve the cognitive and emotional disorders such as memory impairment and anxiety-like behavior of the PS mice to different degrees in behavior. The application discloses that Momordin Ic can improve the PS-related neuropathological changes and behavioral cognitive defects by targeting the SENP1-ZBTB20-SUMO pathway, and provides a new candidate molecule and a clear action target for developing potential therapeutic drugs for Primrose syndrome.

We provide the system. [Solution] A means for receiving audio or text information from an information processing device used by the elderly and generating a conversational response using natural language processing, A means for transmitting the generated conversational response to an information processing device and providing it to the user as audio or text, A method for analyzing conversation records and assessing the risk of memory impairment, A means of generating action improvement suggestions based on risk assessment and providing feedback to users or professionals, A means of supporting dialogue between users, their families, and supporters, A system that includes this.