45 results about "Memory impairment" patented technology

Methods are provided for determining a memory impairment probability. The method comprises receiving one or more audio recordings of an interaction by a user with a computing device during an assessment; extracting acoustic and speech timing features from the one or more audio recordings; applying a machine learning model to the acoustic and speech timing features to generate a memory impairment probability for the user; and providing a clinical decision support recommendation for a provider based on the memory impairment probability.

The present invention relates to a use of a methylated peptide as a therapeutic agent for degenerative brain diseases. Specifically, it has been confirmed that the methylated peptide according to the present invention exhibits improved solubility, bioavailability, phagocytosis by microglia, and anti-inflammatory efficacy compared to a conventional unmodified peptide, and exhibits excellent amyloid beta reduction efficacy compared to a conventional unmodified peptide in an animal model of degenerative brain diseases. Therefore, the methylated peptide according to the present invention can be usefully used as an active ingredient of a composition for preventing or treating degenerative brain diseases and cognitive impairment, learning disability, or memory impairment associated therewith.

The disclosure relates to the use of phosphodiesterase 1 (PDE1) inhibitors for preventing or treating chemobrain, e.g., inhibiting or mitigating one or more symptoms of chemobrain, e.g., feeling of mental fogginess, deficit in attention, disorganized behavior or thinking, confusion, impaired concentration, difficulty finding the right word, difficulty learning new skills, difficulty multitasking, memory impairment (e.g., short-term memory problems, long-term memory problems, impaired verbal memory, impaired visual memory), and / or fatigue.

Provided are compositions and methods for memory enhancement, including recovery of memory impairment. The compositions and methods relate to mannose-6-phosphate and derivatives of mannose-6-phosphate. The methods relate to administration of M6P or derivatives thereof to individuals in whom memory enhancement is desired.

The invention discloses calf animal coccus PD13 for improving Alzheimer's disease and application of the calf animal coccus PD13, and relates to the technical field of biology. Experiments prove that in an Alzheimer's disease model mouse induced by injecting A beta oligomer into the brain, the Azococcus calvus PD13 can improve spatial learning and memory disorder and autonomous exploration ability of the AD model mouse and relieve damage to neurons in a hippocampal region of the Alzheimer's disease model mouse, so that the effect of protecting the neurons is achieved, and the Azococcus calvus PD13 can be used for preparing a medicine for treating the Alzheimer's disease. According to the present invention, with the application of the animal coccus calves, the content of glutathione in mouse serum and the enzyme activity of superoxide dismutase are increased, and the content of malondialdehyde is reduced, such that the animal coccus calves provides good prevention and treatment effects on the Alzheimer's disease, and the new approach is provided for developing the Alzheimer's disease-related drugs.

This invention discloses the application of MYDGF in the prevention and treatment of memory impairment and related diseases. This invention discloses that MYDGF shows significant differences in individuals with memory impairment. After administration of MYDGF, memory impairment can be prevented and memory impairment can be prevented and the death of newly generated neurons can be stopped.

The present invention provides a use of lactoferrin in combination with ergothioneine in the preparation of a drug for preventing and / or treating Alzheimer's disease. Compared with the use of lactoferrin or ergothioneine alone, in the present invention, the combined use of lactoferrin and ergothioneine at a specific ratio as an active pharmaceutical ingredient can reduce cell damage caused by Aβ25-35, reduce the expression of a p-Tau protein, lower the oxidative stress level and regulate apoptosis, alleviate memory impairment and cognitive dysfunction, and can reduce Aβ deposition in mouse plasma.

The invention relates to the technical field of application of natural active substances, in particular to application of octyl gallate in preparation of products for strengthening brain and improving intelligence. According to the application of the octyl gallate in preparation of the products for strengthening the brain and improving intelligence, the oxidative stress level of brain tissue and neuroinflammation response can be effectively relieved, and therefore learning and memory impairment and cognitive function decline caused by chronic sleep interference are improved. The invention finds that the octyl gallate as a polyphenol active substance has good intelligence-promoting and health-care effects, and can be used for preparing health-care foods, functional foods or nutritional supplements for improving learning memory and relieving cognitive dysfunction within a certain dosage range. The octyl gallate is clear in raw material source, can be obtained through natural extraction or chemical synthesis, and has the advantages of being high in safety, wide in application range, remarkable in economic value and the like.

This invention discloses a method for constructing a zebrafish nervous system inflammation model and its applications, belonging to the field of animal neuroinflammation model technology. The method provided by this invention can construct a zebrafish nervous system inflammation model and has the advantages of short modeling time, high success rate, and simplicity. The zebrafish nervous system inflammation model constructed by this invention can be used to develop a drug screening platform for the effects of neuroinflammation, neurodegenerative diseases, and memory impairment, screening for potentially effective drugs by observing behavioral changes in zebrafish. It can also utilize the genetic background of zebrafish to study the molecular mechanisms of memory impairment, providing a theoretical basis for future treatments. It has applications in medicine, drug development, and the screening of natural active ingredients.

The invention discloses Weissella sinus PD13 for improving Alzheimer's disease and application of the Weissella sinus PD13, and relates to the technical field of biological medicine. Experiments prove that Weissella cibaria PD13 can improve spatial learning and memory impairment and autonomous exploration ability of AD model mice in Alzheimer's disease model mice induced by brain injection of A beta oligomer, and alleviate damage of neurons in hippocampal regions of the Alzheimer's disease model mice, so that the effect of protecting neurons is achieved, and the Weissella cibaria PD13 can be used for preparing drugs for treating Alzheimer's disease. According to the present invention, the Weissella cibaricola can effectively prevent and treat the Alzheimer's disease, increase the glutathione content and the superoxide dismutase enzyme activity of the mouse serum, and reduce the malondialdehyde content, such that the Weissella cibaricola has good prevention and treatment effects on the Alzheimer's disease, and the new approach is provided for developing the Alzheimer's disease-related drugs.

The invention discloses application of bifidobacterium longum in preparation of a product for relieving cognitive impairment caused by methylmalonemia, and belongs to the technical field of microorganisms. The Bifidobacterium longum CCFM752 is preserved in the Guangdong Province Microbial Culture Collection Center, the preservation number is GDMCC (China General Microbiological Culture Collection Center) No.61157, and the preservation date is August 21, 2020. The Bifidobacterium longum CCFM752 disclosed by the invention has the advantages that the Bifidobacterium longum CCFM752 can be used for preparing the biological feed additive; the effect of the bifidobacterium longum CCFM752 for relieving the cognitive impairment of the MMA disease is comprehensively evaluated through an MMA model rat, and the effect is specifically reflected as follows: (a) the cognitive and memory impairment is relieved; (b) relieving activation of small glial cells in the hippocampus; (c) reducing the malondialdehyde level in serum and / or tissue to a certain extent; and (d) improving the level of glutathione peroxidase in serum and / or tissues to a certain extent.

The invention discloses an application of lactobacillus plantarum in preparation of a product for relieving individual oxidative stress and cognitive impairment caused by methylmalonic acidmia, the lactobacillus plantarum is preserved in Guangdong Microbial Culture Collection Center, the preservation number is GDMCC No.61163, and the preservation date is August 21, 2020. The lactobacillus plantarum can be applied to preparation of a product for relieving individual oxidative stress and cognitive impairment caused by methylmalonic acidmia. The relieving effect of lactobacillus plantarum CCFM1149 intervention on oxidative damage and cognitive impairment caused by MMA diseases is comprehensively evaluated through MMA model rats, and the relieving effect is specifically reflected as follows: (a) cognitive and memory impairment is relieved; (b) relieving activation of small glial cells in the hippocampus; (c) reducing malondialdehyde levels in serum and / or tissue; and (d) increasing the level of glutathione peroxidase in serum and / or tissues.

The present invention relates to: a composition for improving cognitive function, comprising a natural extract complex; and use thereof. According to an embodiment of the present invention, a composition for improving cognitive function or memory, comprising one or more selected from the group consisting of a Perilla frutescens var. acuta kudo extract, a Moringa oleifera extract, and a Phyllanthus emblica extract, exhibits few side effects due to being based on natural substances, is readily available, and provides an excellent cognitive function improvement effect while being cost-effective. Therefore, the composition can be effectively used for the prevention, amelioration or treatment of diseases associated with cognitive or memory impairment.

A construction method for an experimental animal learning and memory impairment model, comprising: individually housing a CD-1 mouse to allow the CD-1 mouse to develop territorial awareness; subjecting an experimental mouse and the CD-1 mouse to physical confrontation in a cage for a preset duration; and once the experimental mouse has developed acute violent stress, placing the experimental mouse into a Skinner box apparatus to perform a learning ability test, after a preset duration, performing a memory ability test, and after the tests, obtaining the experimental animal learning and memory impairment model. The method assesses animal learning and memory abilities by means of a Skinner box, expands assessment means related to learning and memory, and provides new data support for the construction and assessment of an animal model involving learning and memory impairment induced by acute violent stress.

This application pertains to a compound of Formula (I), Formula (I'), Formula (I") or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein X, R1, R2, R3, R5, R6, and R7 are as defined herein, and uses of such compounds in methods of treating neurodegenerative diseases, neurodevelopmental disorders, and age-related memory impairment.

The application provides a silver fungus vessel-activating and brain-strengthening granule, a preparation method and application, and comprises the following components in parts by weight: wine jujube 10-15 parts, ginkgo leaves 10-15 parts, female privet fruit 8-12 parts, salvia miltiorrhiza 8-12 parts, alocasia 5-7 parts, eucommia ulmoides 8-12 parts, poria cocos 8-12 parts, Uncaria 8-10 parts, Gastrodia 8-12 parts, fried hawthorn 5-7 parts, turmeric 8-10 parts, and chuanxiong 5-7 parts. The silver fungus vessel-activating and brain-strengthening granule has the effect of improving memory impairment of vascular dementia.

A cognitive dysfunction diagnosis device (1) includes: an acquisition unit (41) that acquires a distribution map that shows a distribution of a viewpoint of a subject with respect to a diagnosis image; and a diagnosis unit (39) that diagnoses the diagnosis image that includes a first image and an evaluation image in chronological order, the first image has a first region that includes a memorization image that is visually highlighted and a plurality of second regions that include a general image that is not highlighted, the evaluation image has a third region and the plurality of second regions, the third region includes an evaluation image, the evaluation image is an image that is similar to the memorization image and is displayed without visual highlighting at the same position as the memorization image, the diagnosis unit (39) calculates a fixation rate of the third region in the distribution map with respect to the evaluation image, and in a case where the fixation rate is lower than a threshold value, it is diagnosed that there is a suspicion of memory impairment.

The application belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine supramolecular nanoparticle, which is prepared from Uncaria as a raw medicinal material, is extracted by heating reflux with 68-72% ethanol, is filtered, and is dried after being dialyzed after being dispersed in pure water, centrifuged, resuspended, and centrifuged again. The traditional Chinese medicine supramolecular nanoparticle has uniform particle size, a narrow particle size distribution, and high stability. The nanoparticle has obvious anti-nerve oxidation and obvious nerve protection effects according to in-vitro cell activity detection. The nanoparticle has good in-vivo nerve protection effect, can improve memory impairment and cognitive impairment, and can prevent hippocampal neuron reduction. Compared with Uncaria effective parts, the effective administration dose of the traditional Chinese medicine supramolecular nanoparticle is obviously reduced. The application also discloses a use of the traditional Chinese medicine supramolecular nanoparticle in preparation of a medicine for treating nervous system diseases.

The application discloses a target strategy and a drug intervention method for improving Primrose syndrome, and belongs to the technical field of biological medicine. The experiment proves that Momordin Ic can significantly improve the SUMO level of ZBTB20 in vitro cells or Primrose syndrome (PS) mice, can effectively improve the defects of reduced neuron dendritic branching in the hippocampal CA1 region of the PS mice in pathology, can enhance the complexity, and can improve the cognitive and emotional disorders such as memory impairment and anxiety-like behavior of the PS mice to different degrees in behavior. The application discloses that Momordin Ic can improve the PS-related neuropathological changes and behavioral cognitive defects by targeting the SENP1-ZBTB20-SUMO pathway, and provides a new candidate molecule and a clear action target for developing potential therapeutic drugs for Primrose syndrome.

We provide the system. [Solution] A means for receiving audio or text information from an information processing device used by the elderly and generating a conversational response using natural language processing, A means for transmitting the generated conversational response to an information processing device and providing it to the user as audio or text, A method for analyzing conversation records and assessing the risk of memory impairment, A means of generating action improvement suggestions based on risk assessment and providing feedback to users or professionals, A means of supporting dialogue between users, their families, and supporters, A system that includes this.

The present application relates to a pharmaceutical composition for treating chronic pain and pain-related memory impairment diseases, and belongs to the technical field of biological medicine. Through animal experiments, it is confirmed that the expression of C3 in the hippocampal area of chronic pain mice is increased, and exogenous C3 injection can induce pain and memory impairment phenotype. The present application proposes to use C3-C3aR inhibitors, such as small molecule inhibitor SB290157, to block the pathway. The pharmaceutical composition can be administered by systemic injection or targeted brain region administration to achieve intervention. C3aR inhibitors can simultaneously improve pain behavior and memory function in SNI model mice. By regulating the C3-C3aR signaling pathway in the hippocampal area, the present application directly acts on the pathological core link of pain-memory comorbidity, and provides a small molecule targeted treatment path for chronic pain patients.

The invention discloses an application of an acetylcholine receptor stimulant in treatment of meningitis. It is found for the first time that the acetylcholine receptor stimulant GTS-21 can prevent and treat meningitis and can also prevent and treat cognitive impairment caused by meningitis, a new thought is provided for effective treatment of meningitis and memory impairment caused by meningitis, and the acetylcholine receptor stimulant GTS-21 has wide application prospects.

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative for neurodegenerative diseases, a pharmaceutical composition and application of the piperidine derivative. The piperidine derivative has a structure shown in a general formula (I). In-vivo experiments prove that the compound can effectively improve learning and memory impairment of beta-amyloid protein induced Alzheimer disease model rats, the escape latency is remarkably shortened and the ring penetration frequency is increased in a Morris water maze test, and the behavioral improvement effect of the compound is remarkably superior to that of carristine and can be compared favorably with that of a positive control drug. Meanwhile, the series of compounds can significantly inhibit abnormally increased acetylcholin esterase activity in hippocampal tissues of model rats, have an excellent regulation effect on cholinergic system functions, and show a synergistic effect of cognitive improvement and key pathological link regulation. The compound provided by the invention provides a new and potential candidate drug for treatment of Alzheimer's disease.

The invention discloses a hetero-diad compound taking indanone-tetrahydrothieno [3, 2-c] pyridine as a parent body and a preparation method and application thereof, the hetero-diad compound taking indanone-tetrahydrothieno [3, 2-c] pyridine as the parent body is selected from the compounds shown in the following general formulas (I), (II) and (III), the compound takes indanone of donepezil as a parent nucleus, and the compound is selected from the compounds shown in the general formulas (I), (II) and (III). And the compound is combined with an anti-platelet functional group tetrahydrothieno [3, 2-c] pyridine through a linking group. The compound has multiple action mechanisms (inhibiting AChE, resisting Abeta aggregation, resisting platelet aggregation and improving learning and memory impairment) and high blood-brain barrier permeability, and is suitable for preventing and treating vascular dementia.

The invention provides a construction method and application of a KIF5C gene knockout animal model, and relates to the technical field of biological medicines. The sgRNA for knocking out the KIF5C gene is characterized in that the sequence of the sgRNA is selected from at least one of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and SEQ ID No. 4. The invention further discloses a preparation method of the sgRNA for knocking out the KIF5C gene. The KIF5C gene knockout animal model disclosed by the invention can be used as an animal model for depression and disease research, the KIF5C gene knockout animal model is prepared by adopting a gene knockout technology, and animal behavioral detection shows that a mouse has depression-like symptoms (a sweet water preference experiment and a forced swimming experiment) and memory dysfunction (a Y maze experiment and a conditional fear experiment); the compound has depression symptoms, can be reversed through an antidepressant drug ketamine, and can be used for researching depression animal models and developing corresponding drugs.

The application provides a pharmaceutical composition for preventing and treating senile cognitive impairment with bipolar disorder, a preparation method and application thereof, and belongs to the technical field of medicines.The pharmaceutical composition prepared by mixing volatile oil separated from Acorus calamus and Ligusticum chuanxiong and water extract separated from Acorus calamus, Ligusticum chuanxiong, Astragalus and Polygala is rich in volatile oil and various water-soluble active ingredients.Based on the characteristics of promoting nerve cell growth and memory impairment repair of the pharmaceutical composition, the application also provides application of the pharmaceutical composition in preparation of medicines for preventing and / or treating senile cognitive impairment and / or bipolar disorder.

The present disclosure relates to an application of a peptide in preparing drugs for treating and / or preventing cognitive impairment, belonging to the technical field of drugs for cognitive impairment. The present disclosure discloses an application of an artificially synthesized small molecule peptide in preparing drugs for treating and / or preventing cognitive impairment. When the peptide in the present disclosure is applied to cognitive impairment models, it may effectively play its biological role in blocking the binding between Synapsin IIb (Syn2b) and AMPA receptor subunit (GluA2), enabling the increase of GluA2 membrane expression, increase of AMPA current, enhancement of neuronal excitability and synaptic transmission, thereby alleviating learning and memory impairment in cognitive impairment model mice to some extent.

This invention utilizes *Allium macrostemon* to obtain its aqueous extract, petroleum ether extract, dichloromethane extract, ethyl acetate extract, and n-butanol extract. The effects of these aqueous extracts and extracts of different polarities on the learning and memory functions of D-galactose-induced aging model mice were investigated using Y-maze, darkness avoidance, Morris water maze, and laser speckle cerebral blood flow assays. Reactive oxygen species (ROS), SOD, and MDA were also measured. Multiple experiments demonstrated that *Allium macrostemon* can improve memory function in mice. Furthermore, the effects of *Allium macrostemon* extract on arecoline- or oxidative tremor-induced tremor behavior in mice were studied. The results showed that *Allium macrostemon* extract can effectively shorten the duration of tremors, proposing a new application for *Allium macrostemon* extract in the preparation of drugs for the prevention and / or treatment of neurodegenerative diseases, providing broad application prospects for the treatment or adjuvant therapy of neurodegenerative diseases.

The present application relates to the technical field of traditional Chinese medicine. The present application provides a traditional Chinese medicine composition for preventing and / or treating Alzheimer's disease, which comprises red ginseng and prepared radix falcaliae multiflorae. The present application also provides a preparation method of the traditional Chinese medicine composition for preventing and / or treating Alzheimer's disease. The traditional Chinese medicine composition has a protective effect on HT22 cells induced by A beta 1-42, can improve the anti-aging effect of HT22 cells, can significantly improve the learning and memory impairment of dementia model mice, can prolong the lifespan of N2 wild type Caenorhabditis elegans, can significantly inhibit the production and deposition of beta-amyloid protein closely related to Alzheimer's disease, can significantly activate the expression of hippocampus and cortex SIRT1, can significantly inhibit the expression of hippocampus and cortex aging marker genes of mice, can inhibit brain aging, and thus can effectively prevent and / or treat Alzheimer's disease.

The present disclosure relates to a composition for preventing or treating brain-related inflammation disease or neurodegenerative disease, comprising entrectinib. The composition exhibits an effect of inhibiting brain-related inflammation and alleviating memory impairment, and thus may be usefully used for the prevention, alleviation, or treatment of brain-related inflammation disease, neurodegenerative disease, memory impairment, etc.