27 results about "Memory impairment" patented technology

The present invention relates to a use of a methylated peptide as a therapeutic agent for degenerative brain diseases. Specifically, it has been confirmed that the methylated peptide according to the present invention exhibits improved solubility, bioavailability, phagocytosis by microglia, and anti-inflammatory efficacy compared to a conventional unmodified peptide, and exhibits excellent amyloid beta reduction efficacy compared to a conventional unmodified peptide in an animal model of degenerative brain diseases. Therefore, the methylated peptide according to the present invention can be usefully used as an active ingredient of a composition for preventing or treating degenerative brain diseases and cognitive impairment, learning disability, or memory impairment associated therewith.

This invention discloses the application of MYDGF in the prevention and treatment of memory impairment and related diseases. This invention discloses that MYDGF shows significant differences in individuals with memory impairment. After administration of MYDGF, memory impairment can be prevented and memory impairment can be prevented and the death of newly generated neurons can be stopped.

The present invention provides a use of lactoferrin in combination with ergothioneine in the preparation of a drug for preventing and / or treating Alzheimer's disease. Compared with the use of lactoferrin or ergothioneine alone, in the present invention, the combined use of lactoferrin and ergothioneine at a specific ratio as an active pharmaceutical ingredient can reduce cell damage caused by Aβ25-35, reduce the expression of a p-Tau protein, lower the oxidative stress level and regulate apoptosis, alleviate memory impairment and cognitive dysfunction, and can reduce Aβ deposition in mouse plasma.

The invention relates to the technical field of application of natural active substances, in particular to application of octyl gallate in preparation of products for strengthening brain and improving intelligence. According to the application of the octyl gallate in preparation of the products for strengthening the brain and improving intelligence, the oxidative stress level of brain tissue and neuroinflammation response can be effectively relieved, and therefore learning and memory impairment and cognitive function decline caused by chronic sleep interference are improved. The invention finds that the octyl gallate as a polyphenol active substance has good intelligence-promoting and health-care effects, and can be used for preparing health-care foods, functional foods or nutritional supplements for improving learning memory and relieving cognitive dysfunction within a certain dosage range. The octyl gallate is clear in raw material source, can be obtained through natural extraction or chemical synthesis, and has the advantages of being high in safety, wide in application range, remarkable in economic value and the like.

This invention discloses a method for constructing a zebrafish nervous system inflammation model and its applications, belonging to the field of animal neuroinflammation model technology. The method provided by this invention can construct a zebrafish nervous system inflammation model and has the advantages of short modeling time, high success rate, and simplicity. The zebrafish nervous system inflammation model constructed by this invention can be used to develop a drug screening platform for the effects of neuroinflammation, neurodegenerative diseases, and memory impairment, screening for potentially effective drugs by observing behavioral changes in zebrafish. It can also utilize the genetic background of zebrafish to study the molecular mechanisms of memory impairment, providing a theoretical basis for future treatments. It has applications in medicine, drug development, and the screening of natural active ingredients.

A construction method for an experimental animal learning and memory impairment model, comprising: individually housing a CD-1 mouse to allow the CD-1 mouse to develop territorial awareness; subjecting an experimental mouse and the CD-1 mouse to physical confrontation in a cage for a preset duration; and once the experimental mouse has developed acute violent stress, placing the experimental mouse into a Skinner box apparatus to perform a learning ability test, after a preset duration, performing a memory ability test, and after the tests, obtaining the experimental animal learning and memory impairment model. The method assesses animal learning and memory abilities by means of a Skinner box, expands assessment means related to learning and memory, and provides new data support for the construction and assessment of an animal model involving learning and memory impairment induced by acute violent stress.

This application pertains to a compound of Formula (I), Formula (I'), Formula (I") or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein X, R1, R2, R3, R5, R6, and R7 are as defined herein, and uses of such compounds in methods of treating neurodegenerative diseases, neurodevelopmental disorders, and age-related memory impairment.

The application provides a silver fungus vessel-activating and brain-strengthening granule, a preparation method and application, and comprises the following components in parts by weight: wine jujube 10-15 parts, ginkgo leaves 10-15 parts, female privet fruit 8-12 parts, salvia miltiorrhiza 8-12 parts, alocasia 5-7 parts, eucommia ulmoides 8-12 parts, poria cocos 8-12 parts, Uncaria 8-10 parts, Gastrodia 8-12 parts, fried hawthorn 5-7 parts, turmeric 8-10 parts, and chuanxiong 5-7 parts. The silver fungus vessel-activating and brain-strengthening granule has the effect of improving memory impairment of vascular dementia.

The application belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine supramolecular nanoparticle, which is prepared from Uncaria as a raw medicinal material, is extracted by heating reflux with 68-72% ethanol, is filtered, and is dried after being dialyzed after being dispersed in pure water, centrifuged, resuspended, and centrifuged again. The traditional Chinese medicine supramolecular nanoparticle has uniform particle size, a narrow particle size distribution, and high stability. The nanoparticle has obvious anti-nerve oxidation and obvious nerve protection effects according to in-vitro cell activity detection. The nanoparticle has good in-vivo nerve protection effect, can improve memory impairment and cognitive impairment, and can prevent hippocampal neuron reduction. Compared with Uncaria effective parts, the effective administration dose of the traditional Chinese medicine supramolecular nanoparticle is obviously reduced. The application also discloses a use of the traditional Chinese medicine supramolecular nanoparticle in preparation of a medicine for treating nervous system diseases.

The application discloses a target strategy and a drug intervention method for improving Primrose syndrome, and belongs to the technical field of biological medicine. The experiment proves that Momordin Ic can significantly improve the SUMO level of ZBTB20 in vitro cells or Primrose syndrome (PS) mice, can effectively improve the defects of reduced neuron dendritic branching in the hippocampal CA1 region of the PS mice in pathology, can enhance the complexity, and can improve the cognitive and emotional disorders such as memory impairment and anxiety-like behavior of the PS mice to different degrees in behavior. The application discloses that Momordin Ic can improve the PS-related neuropathological changes and behavioral cognitive defects by targeting the SENP1-ZBTB20-SUMO pathway, and provides a new candidate molecule and a clear action target for developing potential therapeutic drugs for Primrose syndrome.

We provide the system. [Solution] A means for receiving audio or text information from an information processing device used by the elderly and generating a conversational response using natural language processing, A means for transmitting the generated conversational response to an information processing device and providing it to the user as audio or text, A method for analyzing conversation records and assessing the risk of memory impairment, A means of generating action improvement suggestions based on risk assessment and providing feedback to users or professionals, A means of supporting dialogue between users, their families, and supporters, A system that includes this.

The present application relates to a pharmaceutical composition for treating chronic pain and pain-related memory impairment diseases, and belongs to the technical field of biological medicine. Through animal experiments, it is confirmed that the expression of C3 in the hippocampal area of chronic pain mice is increased, and exogenous C3 injection can induce pain and memory impairment phenotype. The present application proposes to use C3-C3aR inhibitors, such as small molecule inhibitor SB290157, to block the pathway. The pharmaceutical composition can be administered by systemic injection or targeted brain region administration to achieve intervention. C3aR inhibitors can simultaneously improve pain behavior and memory function in SNI model mice. By regulating the C3-C3aR signaling pathway in the hippocampal area, the present application directly acts on the pathological core link of pain-memory comorbidity, and provides a small molecule targeted treatment path for chronic pain patients.

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative for neurodegenerative diseases, a pharmaceutical composition and application of the piperidine derivative. The piperidine derivative has a structure shown in a general formula (I). In-vivo experiments prove that the compound can effectively improve learning and memory impairment of beta-amyloid protein induced Alzheimer disease model rats, the escape latency is remarkably shortened and the ring penetration frequency is increased in a Morris water maze test, and the behavioral improvement effect of the compound is remarkably superior to that of carristine and can be compared favorably with that of a positive control drug. Meanwhile, the series of compounds can significantly inhibit abnormally increased acetylcholin esterase activity in hippocampal tissues of model rats, have an excellent regulation effect on cholinergic system functions, and show a synergistic effect of cognitive improvement and key pathological link regulation. The compound provided by the invention provides a new and potential candidate drug for treatment of Alzheimer's disease.

The application provides a pharmaceutical composition for preventing and treating senile cognitive impairment with bipolar disorder, a preparation method and application thereof, and belongs to the technical field of medicines.The pharmaceutical composition prepared by mixing volatile oil separated from Acorus calamus and Ligusticum chuanxiong and water extract separated from Acorus calamus, Ligusticum chuanxiong, Astragalus and Polygala is rich in volatile oil and various water-soluble active ingredients.Based on the characteristics of promoting nerve cell growth and memory impairment repair of the pharmaceutical composition, the application also provides application of the pharmaceutical composition in preparation of medicines for preventing and / or treating senile cognitive impairment and / or bipolar disorder.

The present disclosure relates to an application of a peptide in preparing drugs for treating and / or preventing cognitive impairment, belonging to the technical field of drugs for cognitive impairment. The present disclosure discloses an application of an artificially synthesized small molecule peptide in preparing drugs for treating and / or preventing cognitive impairment. When the peptide in the present disclosure is applied to cognitive impairment models, it may effectively play its biological role in blocking the binding between Synapsin IIb (Syn2b) and AMPA receptor subunit (GluA2), enabling the increase of GluA2 membrane expression, increase of AMPA current, enhancement of neuronal excitability and synaptic transmission, thereby alleviating learning and memory impairment in cognitive impairment model mice to some extent.

This invention utilizes *Allium macrostemon* to obtain its aqueous extract, petroleum ether extract, dichloromethane extract, ethyl acetate extract, and n-butanol extract. The effects of these aqueous extracts and extracts of different polarities on the learning and memory functions of D-galactose-induced aging model mice were investigated using Y-maze, darkness avoidance, Morris water maze, and laser speckle cerebral blood flow assays. Reactive oxygen species (ROS), SOD, and MDA were also measured. Multiple experiments demonstrated that *Allium macrostemon* can improve memory function in mice. Furthermore, the effects of *Allium macrostemon* extract on arecoline- or oxidative tremor-induced tremor behavior in mice were studied. The results showed that *Allium macrostemon* extract can effectively shorten the duration of tremors, proposing a new application for *Allium macrostemon* extract in the preparation of drugs for the prevention and / or treatment of neurodegenerative diseases, providing broad application prospects for the treatment or adjuvant therapy of neurodegenerative diseases.

The present application relates to the technical field of traditional Chinese medicine. The present application provides a traditional Chinese medicine composition for preventing and / or treating Alzheimer's disease, which comprises red ginseng and prepared radix falcaliae multiflorae. The present application also provides a preparation method of the traditional Chinese medicine composition for preventing and / or treating Alzheimer's disease. The traditional Chinese medicine composition has a protective effect on HT22 cells induced by A beta 1-42, can improve the anti-aging effect of HT22 cells, can significantly improve the learning and memory impairment of dementia model mice, can prolong the lifespan of N2 wild type Caenorhabditis elegans, can significantly inhibit the production and deposition of beta-amyloid protein closely related to Alzheimer's disease, can significantly activate the expression of hippocampus and cortex SIRT1, can significantly inhibit the expression of hippocampus and cortex aging marker genes of mice, can inhibit brain aging, and thus can effectively prevent and / or treat Alzheimer's disease.

The present disclosure relates to a composition for preventing or treating brain-related inflammation disease or neurodegenerative disease, comprising entrectinib. The composition exhibits an effect of inhibiting brain-related inflammation and alleviating memory impairment, and thus may be usefully used for the prevention, alleviation, or treatment of brain-related inflammation disease, neurodegenerative disease, memory impairment, etc.

The invention relates to application of KLF4 as a target spot in APOE4 genotype Alzheimer disease, and belongs to the technical field of biological medicine. The invention provides an application of KLF4 in preparation of any one of the following medicines: (1) improving learning and memory ability impairment; (2) the blood-brain barrier function is improved; and (3) treating or preventing neurodegenerative diseases. According to the application disclosed by the invention, the expression of KLF4 in cerebral cortex of APOE4 genotype patients and mice is obviously reduced, the KLF4 in APOE4 mice is obviously lower than that in APOE3 mice, and the cortex expression of APOE4 carriers is lower than that of non-carriers. According to the application disclosed by the invention, in-depth research by taking the KLF4 as an entry point finds that the APOE4 reduces the expression of the KLF4 and destroys a BBB structure, so that learning and memory impairment is caused, and then the APOE4 develops into neurodegenerative diseases, and the symptoms can be improved by overexpression of the KLF4.

To provide a method for evaluating dementia, and a composition for preventing or treating a decline in brain function, or for maintaining or improving brain function. [Solution] The gut microbiota of healthy individuals, individuals with mild cognitive impairment, and individuals with Alzheimer's disease were compared. As a result, microorganisms belonging to the genus Faecalibacterium were selected as gut microbiota associated with cognitive function. Furthermore, it was revealed that Faecalibacterium prausnitzii, which possesses specific DNA, has an improving effect on cognitive decline such as learning and memory impairment.

The invention belongs to the technical field of essential oil, and particularly provides compound essential oil for improving learning and memory disorders as well as a preparation method and application of the compound essential oil. The liquid compound essential oil comprises the following raw materials in parts by weight: 30-40 parts of ginseng essential oil, 10-15 parts of rhizoma acori graminei essential oil, 1-5 parts of frankincense essential oil, 30-40 parts of perilla essential oil, 1-5 parts of borneol and 1-5 parts of ginkgo leaf essential oil. The compound essential oil for improving learning and memory disorders provided by the invention takes multiple traditional Chinese medicine extracts as raw materials, so that the compound essential oil has the effects of tonifying qi and inducing resuscitation, refreshing mind and restoring consciousness, soothing nerves and stabilizing mind and enhancing memory.

The invention belongs to the technical field of neurobiology, and particularly relates to a targeted NPTX1-Kv7.2 signal axis for inhibiting neuronal hyperexcitation and improving memory impairment formed by aging. According to the invention, a scene fear memory mouse behavior model is adopted, experimental research is carried out by combining in-vitro brain slice patch clamp recording, single-molecule fluorescence in situ hybridization, immunohistochemistry and other methods, and the result shows that NPTX1 can be used as a cognitive disorder molecular marker, and neuronal hyperactivity caused by aging can be rescued by specifically supplementing NPTX1 in a DG brain region; the activation of DG neurons during scene fear experience is improved, and neuronal activation damage and dysmnesia caused by aging are improved; the retigabine serving as an agonist of the NPTX1 interaction protein Kv7.2 is injected in the intraperitoneal cavity, so that neuron activation damage and dysmnesia caused by senescence can also be effectively improved. The invention discloses the effect of the NPTX1-Kv7.2 signal axis in improving the memory impairment of an aging individual, and provides a new thought and target spot for treating the memory impairment caused by aging.

This invention relates to a method and device for exercise intervention to improve nonylphenol-induced learning and memory impairment. By constructing an animal treadmill exercise model, experimental mice were randomly grouped and subjected to exercise interventions of different intensities. The effects of exercise on behavioral performance and biological indicators were systematically evaluated. Results showed that low-intensity and moderate-intensity exercise significantly improved the learning and memory abilities of mice. Metabolic and molecular biological analyses revealed that moderate exercise effectively restored NAD⁺ levels and the activity of related energy metabolism pathways in the hippocampus, and regulated the expression of key molecules such as AMPK and BDNF, thereby improving impaired neuroplasticity. This method optimizes exercise intensity to achieve synergistic regulation of neural function and metabolic networks, avoiding interference from traditional stress factors and improving the reliability of the data. This invention provides a safe and effective technical solution for intervention research in environmental toxicology and neurodegenerative damage, and has promising application prospects.

The invention discloses an application of stenotrophomonas maltophilia in preparation of a medicine for preventing or treating Alzheimer's disease. Specifically, the stenotrophomonas maltophilia has the purposes of reducing beta amyloid protein aggregation, relieving learning and memory impairment, promoting autophagy and the like, and an effective scheme is provided for preventing and treating the Alzheimer's disease.

The invention discloses an application of sildenafil in preparation of an anti-aging drug. According to the application disclosed by the invention, sildenafil is found to be capable of effectively inhibiting senescence of microglial cells, reducing the expression of cell senescence markers p21, gamma H2Ax, p16 and H3k9me3, and recovering the expression of Lamin B1 and pRb. In a mouse in-vivo experiment, sildenafil can be used for remarkably improving cognitive impairment and learning and memory ability damage caused by aging and reducing the transcription expression level of inflammatory factors Mcp1, Tnf, Il1a and Il1b. In conclusion, the inventor puts forward that anti-aging is a brand-new adaptation disease of sildenafil, and sildenafil can be used for preparing anti-aging drugs.

The application discloses a kind of polypeptide and its application in improving learning and memory impairment of Alzheimer's disease.The application utilizes the fusion protein polypeptide TAT-P-1082 of artificially synthesized TAT protein transduction domain and P-1082, and TAT can carry P-1082 protein polypeptide to be taken up by neuron through blood brain barrier by blood, and is applied to mouse model in vivo, can effectively exert its biological effect of blocking E2 ubiquitin binding enzyme UBE2K and GluN2B receptor binding, so that the ubiquitination level of GluN2B receptor is reduced, and protein level is increased, so as to improve learning and memory impairment of Alzheimer's disease.

The present invention relates to a cognitive function and memory improvement composition comprising a natural extract mixture, and a use thereof. The cognitive function or memory improvement composition comprising a Perilla frutescens var. acuta Kudo extract and a peppermint (Mentha piperita) extract, according to one embodiment of the present invention, is based on natural materials and has few side effects, is easily accessible, and has economic efficiency while exhibiting an excellent cognitive function improvement effect, and thus may be usefully employed for the prevention, mitigation, or treatment of cognitive impairment- or memory impairment-related diseases.