39 results about "Learning memory" patented technology

The invention discloses design and synthesis of a series of brain-targeted ginsenoside Rg1 derivatives and application of the brain-targeted ginsenoside Rg1 derivatives in treatment of Alzheimer's disease. According to the invention, ginsenoside Rg1 and polyethylene glycol with a specific chain length are covalently linked to successfully construct the derivative capable of enhancing the penetrating power of the blood-brain barrier. The series of derivatives provided by the invention not only solve the problems of poor brain targeting and insufficient stability of natural Rg1, but also can inhibit neuroinflammation by regulating and controlling an NLRP3 / caspase-1 signal channel in an LPS-induced neuroinflammation model, and finally, the learning and memory ability is remarkably improved. The product is simple and convenient in preparation process and good in biological safety, and a new candidate compound is provided for developing a new generation of Alzheimer disease treatment medicines.

The invention relates to the technical field of medicines, in particular to application of osthole in preparation of a medicine for protecting cognitive function impairment caused by down-regulation of an estrogen receptor. The OST has an improvement effect on the learning and memory ability and pathological damage of 6-month-old female peripheral ERs down-regulated mice and ER alpha- / -mouse models. The mechanism of the OST for improving learning and memory may be related to improvement of neuroplasticity, inhibition of nerve apoptosis and enhancement of neurotransmitter by regulating and controlling an estrogen-cholinergic system by the OST. The OST has a better intervention effect on a 6-month-old female ER alpha- / -mouse model, and possibly is a kidney-tonifying medicine which acts on a related target spot of a peripheral target organ so as to participate in regulation of a cognitive function of a central system.

The invention relates to the technical field of functional food, health care products and medicines, in particular to a composition for neuroprotection and cognitive function improvement and a preparation method and application thereof. The invention provides a composition for neuroprotection and cognitive function improvement. The composition is prepared from calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, by compounding the calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, the compound has a synergistic effect and can be applied to preparation of food, health care products or medicines for protecting nerves, delaying nerve aging, improving learning and memory ability, repairing nerve injury and preventing or assisting in treating neurodegenerative diseases.

The invention provides a composition for improving learning memory, spatial memory and / or cognitive functions and application thereof. The composition disclosed by the invention comprises DHA (docosahexaenoic acid) and galactose, and the mass ratio of the DHA to the galactose is 1: (8-260). The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product helpful for improving spatial memory, working memory and / or cognitive function.

The invention discloses a nutritional composition for promoting brain development and application thereof, and relates to the technical field of biological medicines. The compound composition is selected from a composition A (melatonin + uridylic acid + inositol), a composition B (melatonin + uridylic acid) and a composition C (uridylic acid + inositol). Experiments prove that the combination B can significantly improve elevated anxiety behaviors and learning and memory ability caused by rhythm disorder, the combination C can significantly improve open field anxiety behaviors caused by rhythm disorder, and the combination A can significantly relieve anxiety behaviors (including elevated and open field) and spatial learning and memory ability disorder caused by rhythm disorder at the same time. The active components in the compound composition disclosed by the invention are remarkable in synergistic effect, high in safety and good in biocompatibility, and can be used for preparing medicines, food additives or feed additives for improving rhythm disorder related brain dysplasia.

The application relates to the technical field of intelligent evaluation of medical education, in particular to a text-guided intelligent evaluation method for clinical skills based on a ranking graph constraint. The method comprises the following steps: segmenting and extracting features from a clinical skill video, pre-processing the video, combining video time sequence information and action speed text embedding to construct a time sequence feature representation, introducing skill classification text and a learnable memory embedding vector, realizing multi-modal feature decoding based on a cross-attention mechanism, outputting a skill score prediction value through a scoring network, constructing a ranking relationship matrix by using real score differences, introducing a ranking graph constraint loss and a scoring loss for joint optimization, and thus improving the accuracy and ranking consistency of skill evaluation. The application realizes accurate modeling of a clinical skill operation process and effective discrimination of relative levels between samples, thereby significantly improving the accuracy, consistency and reliability of skill evaluation.

The present application provides a kind of nutritional composition in the application of the product for improving learning, memory and cognitive ability.The nutritional composition includes animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose.Animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose can synergistically enhance the memory retention ability of the body, reduce the degree of learning and memory errors, and up-regulate the expression of oligodendrocyte transcription factor 2 coding gene, myelin basic protein coding gene and brain-derived neurotrophic factor coding gene, realize the double regulation of myelin formation and neurotrophic in hippocampus region of brain, synergistically improve the neural plasticity of central nervous system through gut-brain axis pathway, and then double improve the learning, memory and cognitive function of the body from the behavior and molecular level.

The invention discloses mRNA (messenger Ribonucleic Acid) of an m6A methylation modified Ncam1 gene and an application of the mRNA. The invention discloses mRNA (messenger ribonucleic acid) of an m6A methylation modified Ncam1 gene. A modification site is selected from adenylic acid of at least one site of the 313th site, the 617th site, the 705th site, the 769th site, the 903rd site, the 1034th site, the 1202nd site or the 1430th site of the Ncam1 gene. The application comprises the application in up-regulation of Ncam1 protein expression and the application in up-regulation of Ncam1 protein expression. Application in inhibition of neuronal aging; application in preparation of a product for treating and / or improving Alzheimer's disease; the invention relates to application in preparation of drugs for regulating learning and memory ability decline related diseases. The mRNA provided by the invention regulates self expression through the change of m6A site methylation modification level and affects synaptic related genes and neuronal aging process, so that learning and memory processes are affected, and symptoms related to AD, aging and neurodegenerative diseases are improved.

The invention relates to the technical field of application of natural active substances, in particular to application of octyl gallate in preparation of products for strengthening brain and improving intelligence. According to the application of the octyl gallate in preparation of the products for strengthening the brain and improving intelligence, the oxidative stress level of brain tissue and neuroinflammation response can be effectively relieved, and therefore learning and memory impairment and cognitive function decline caused by chronic sleep interference are improved. The invention finds that the octyl gallate as a polyphenol active substance has good intelligence-promoting and health-care effects, and can be used for preparing health-care foods, functional foods or nutritional supplements for improving learning memory and relieving cognitive dysfunction within a certain dosage range. The octyl gallate is clear in raw material source, can be obtained through natural extraction or chemical synthesis, and has the advantages of being high in safety, wide in application range, remarkable in economic value and the like.

This invention relates to the field of biomedical technology, specifically disclosing a cognitive impairment model, its uses, and the application of compound MT-1207 in the prevention and treatment of cognitive impairment. The structure of compound MT-1207 is shown in formula (I). This invention is the first to discover that 2K2C rats can serve as a cognitive impairment model and can be used for screening related drugs for cognitive impairment. Compound MT-1207 can improve cognitive function impairment in 2K2C rats, significantly improving the rats' movement distance, latency, number of platform crossings, and time spent in the target quadrant, and can improve the rats' learning and memory abilities.

The invention relates to glycopeptide for improving sleep and application thereof, and relates to the technical field of biological medicine. The glycopeptide can increase the sleep duration and improve the sleep stability, has the efficacy of improving sleep, and can also significantly improve the learning and memory ability of insomnia patients.

The invention proposes a knee joint image segmentation method, and the method comprises the steps: adding a multi-scale memory storage module to the Botleneck of each level of a U-Net network, carrying out the multi-scale feature fusion of features outputted by a corresponding layer of an encoder through the multi-scale memory storage module, carrying out the feature storage, optimization and updating of the fusion features based on an updating rule, and carrying out the segmentation of a knee joint image. And then, further fusing with the obtained fusion feature to obtain an output feature, and carrying out jumper fusion on the output feature and the decoder at the corresponding layer of the decoder, so that the extraction capability of the U-Net network on the bottom-layer feature is improved, the dependence of dissimilatory data learning on original data is reduced, and the learning and identification capability of small organs can be realized. And the learning and memory ability of different sex data is improved, and the problem of information forgetting caused by data differences is reduced.

The invention relates to the technical field of biological medicine, and particularly discloses application of ROMO1 gene in preparation of medicine for treating Alzheimer's disease. The invention finds that overexpressed ROMO1 protein can treat the Alzheimer's disease through multi-aspect experimental research, and further provides application of the ROMO1 gene in preparation of drugs for treating the Alzheimer's disease. A technician in the field can introduce the ROMO1 gene into a body through an overexpression system, so that the overexpression of the ROMO1 protein is realized; according to the present invention, the Alzheimer's disease treatment effects are provided from the aspects of learning and memory ability improving, A [beta] plaque deposition reducing, astrocyte hyperplasia reducing, microglial cell excessive activation reducing, neuronal synaptic integrity maintaining, brain mitochondrial function enhancing and the like, and the new method is provided for Alzheimer's disease treatment.

The invention provides a composition for improving learning memory and / or cognitive function and application thereof. The composition provided by the invention comprises alpha-choline glycerophosphate and galactose, and the mass ratio of the alpha-choline glycerophosphate to the galactose is 1: (8-100). The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product helpful for improving learning memory and / or cognitive functions.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a thyroid function regulation and control preparation based on an astragalus membranaceus fermentation extract and a preparation method thereof, and the preparation is technically characterized in that the preparation takes an extract obtained after astragalus membranaceus is fermented by specific microorganisms (such as lactobacillus plantarum) as an active ingredient. Systematic iodine deficiency rat model experiments prove that the fermentation extract has obviously better effects in the aspects of improving thyroid functions and forms (such as adjusting FT3, FT4, TSH and TPO-Ab), enhancing body antioxidant ability (such as improving activity of SOD and CAT of hippocampus and liver) and improving learning and memory behaviors than a traditional astragalus extract. The invention provides an effective scheme for developing an innovative traditional Chinese medicine preparation for comprehensively preventing and treating the iodine deficiency thyroid disease and complications thereof.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a tryptamine compound, a preparation method thereof and application of the tryptamine compound in preparation of a medicine for enhancing learning and memory. The tryptamine compound provided by the invention has a structure as shown in formula 1. The tryptamine compound with the structure as shown in the formula 1 provided by the invention can simultaneously excite a Sigma-1 receptor and a 5-HT2A receptor to play a role, is a dual agonist of the Sigma-1 receptor and the 5-HT2A receptor, and shows the effects of complementing action mechanisms, synergistically enhancing neuroprotection, expanding the action brain region range and reducing side effects. Compared with a traditional medicine for enhancing the learning and memory ability, the tryptamine compound with the structure as shown in the formula 1 has the function of remarkably improving the learning and memory activity. Formula 1.

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative for neurodegenerative diseases, a pharmaceutical composition and application of the piperidine derivative. The piperidine derivative has a structure shown in a general formula (I). In-vivo experiments prove that the compound can effectively improve learning and memory impairment of beta-amyloid protein induced Alzheimer disease model rats, the escape latency is remarkably shortened and the ring penetration frequency is increased in a Morris water maze test, and the behavioral improvement effect of the compound is remarkably superior to that of carristine and can be compared favorably with that of a positive control drug. Meanwhile, the series of compounds can significantly inhibit abnormally increased acetylcholin esterase activity in hippocampal tissues of model rats, have an excellent regulation effect on cholinergic system functions, and show a synergistic effect of cognitive improvement and key pathological link regulation. The compound provided by the invention provides a new and potential candidate drug for treatment of Alzheimer's disease.

The present application belongs to the technical field of pharmaceutical compositions, and particularly relates to a composition containing yak milk fat globule membrane and capable of improving cognitive function decline and application thereof. The composition takes yak milk fat globule membrane as a core active ingredient, and takes taurine, selenium-rich yeast and yam extract as auxiliary active ingredients. Through synergistic effect of the components, the composition can target inhibit acetylcholinesterase activity, relieve oxidative stress damage of brain nerve cells, reduce the level of pro-inflammatory factors in the brain, and then significantly improve cognitive function. The composition takes into account functionality and nutrition, and shows broad application prospects in the development of products related to improving learning and memory ability, delaying cognitive function decline and improving cognitive impairment.

The invention provides a neuroprotective effect of DIRAS1 on Alzheimer's disease (AD), and belongs to the technical field of biological medicine. The invention provides application of a reagent for overexpressing a DIRAS1 gene in preparation of a medicine for preventing and / or treating AD by taking the DIRAS1 gene as a therapeutic target of AD. The treatment of a model mouse in the embodiment finds that the DIRAS1 gene is over-expressed in the brain of the AD mouse, and the cognitive function detection finds that the recognition memory, the working memory and the long-term spatial learning memory of the AD mouse can be remarkably improved; morphological and molecular biological detection finds that deposition of A beta and excessive phosphorylation of Tau protein are reduced, and Golgi staining and western blot detection finds that damage to a synaptic structure is reduced and expression of synaptic related protein is increased. Therefore, the cognitive function, pathological characteristics and synaptic plasticity of AD mice can be improved by a method of overexpressing the DIRAS1 gene.

The application provides a composition for improving learning memory and / or cognitive function and application thereof. The composition of the application comprises alpha-glycerophosphocholine and galactose, wherein the mass ratio of the alpha-glycerophosphocholine to the galactose is 1:(8-100).

The application belongs to the field of biological medicine and microecological intervention technology, and relates to application of Bacillus coagulans T-21 in reducing ulcerative colitis combined with cognitive dysfunction. A dextran sodium sulfate (DSS) induced mouse ulcerative colitis combined with cognitive dysfunction model is established by taking a Bacillus coagulans T-21 strain as an active ingredient, and an intervention effect is evaluated. Results show that the Bacillus coagulans T-21 intervention can improve the cognitive related behavior performance and learning and memory ability of the model mice, thereby reducing ulcerative colitis related cognitive dysfunction. Meanwhile, the Bacillus coagulans T-21 intervention can increase the colon length, up-regulate the expression of tight junction proteins Occludin, Claudin-1 and Claudin-5 in colon tissue, improve the intestinal mucosal barrier damage, and down-regulate the expression levels of pro-inflammatory factors IL-1beta in colon tissue and IL-6 in hippocampus tissue, thereby reducing intestinal and central inflammatory reactions.

Aspects of the invention are directed to methods of stimulating or promoting neurogenesis by administering to a subject of a composition comprising a cyclodextrin and a polyethylene glycol to alleviate learning, memory and cognitive deficits present in subjects afflicted with various brain disorders or from neurodegenerative disorder associated with aging.

The invention provides modified milk powder capable of improving learning memory and / or cognitive functions as well as a preparation method and application of the modified milk powder. The total protein content of the modified milk powder is 16.5-30 g / 100 g, the fat content of the modified milk powder is 10-35 g / 100 g, the carbohydrate content of the modified milk powder is 35-70 g / 100 g, the modified milk powder comprises alpha-choline alfoscerate and galactose, and the mass ratio of the alpha-choline alfoscerate to the galactose is 1: (8-100). The modified milk powder disclosed by the invention is beneficial to improving learning memory and / or cognitive functions.

The invention relates to application of KLF4 as a target spot in APOE4 genotype Alzheimer disease, and belongs to the technical field of biological medicine. The invention provides an application of KLF4 in preparation of any one of the following medicines: (1) improving learning and memory ability impairment; (2) the blood-brain barrier function is improved; and (3) treating or preventing neurodegenerative diseases. According to the application disclosed by the invention, the expression of KLF4 in cerebral cortex of APOE4 genotype patients and mice is obviously reduced, the KLF4 in APOE4 mice is obviously lower than that in APOE3 mice, and the cortex expression of APOE4 carriers is lower than that of non-carriers. According to the application disclosed by the invention, in-depth research by taking the KLF4 as an entry point finds that the APOE4 reduces the expression of the KLF4 and destroys a BBB structure, so that learning and memory impairment is caused, and then the APOE4 develops into neurodegenerative diseases, and the symptoms can be improved by overexpression of the KLF4.

The invention discloses an application of a CHRNA3 agonist in treatment of memory down-regulation induced by low-pressure and low-oxygen stress. It is found for the first time that a CHRNA3 agonist can effectively relieve learning and memory ability decline induced by hypoxia stress, based on the regulation and control relation of miR-24 and CHRNA3, the computer-aided drug screening method, system and equipment based on miR-24 and CHRNA3 are provided, a new thought and direction are provided for treatment of learning and memory ability decline induced by hypoxia stress, and the method, the system and the equipment have good application prospects. The application prospect is wide.

The invention discloses a ginkgo biloba extract dropping pill for synergistically improving vascular cognitive impairment through multiple ways and application of the ginkgo biloba extract dropping pill, and belongs to the technical field of new application of medicines. The ginkgo biloba extract dropping pill has a synergistic effect through five ways of oxidative stress regulation, neuroinflammation inhibition, cholinergic system regulation and control, neuronal apoptosis inhibition and intestinal-brain axis regulation, and can up-regulate the activity of antioxidant enzymes, reduce the expression of proinflammatory factors, improve the content of acetylcholine, regulate and control apoptosis-related proteins and repair intestinal flora balance. After intragastric administration, learning memory and social functions can be improved, the content of neurotransmitters in cerebrospinal fluid and brain homogenate can be adjusted, and pathological injuries of hippocampus tissues can be relieved. The mechanism is accurate, the effect is remarkable, a new choice is provided for clinical treatment of the vascular cognitive impairment, and the application prospect is wide.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating senile dementia and a preparation method thereof. The invention discloses a traditional Chinese medicine composition for treating senile dementia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 23-28 parts of rhizoma coptidis, 20-25 parts of cortex cinnamomi, 18-22 parts of herba lysimachiae, 13-19 parts of rhizoma acori graminei, 15-20 parts of radix polygalae, 9-13 parts of radix rehmanniae praeparata, 6-12 parts of caulis sargentodoxae, 7-11 parts of poria cocos and 3-8 parts of radix glycyrrhizae. Test results show that by taking the traditional Chinese medicine composition for treating the senile dementia, the learning and memory ability of a senile dementia model mouse can be remarkably improved, A beta deposition in the brain can be reduced, the safety is good, and a novel traditional Chinese medicine scheme which is safe, effective and clear in mechanism is provided for the senile dementia.

The present application relates to a glycopeptide for improving sleep and application thereof, and relates to the technical field of biological medicine. The glycopeptide can increase sleep duration, improve sleep stability, has the effect of improving sleep, and can also significantly improve the learning and memory ability of patients with insomnia.

The invention discloses extracellular vesicles prepared from lactobacillus reuteri CCFM1040 and used for preventing and relieving senescence syndromes, and belongs to the technical field of microorganisms and the technical field of medicines. The lactobacillus reuteri CCFM1040 source extracellular vesicles obtained by adopting an ultracentrifugation method can be used for improving the learning, memory and cognitive abilities, enhancing the muscle strength ability, improving the exercise coordination ability, enhancing the exercise balance ability and remarkably reducing the level of inflammatory factors IL-6 in blood, hippocampus and skin tissues; the enzyme activity of the senescence-related enzyme SA-beta-Gal in the brain tissue is obviously reduced; the collagen content and the collagen synthesis capability in skin tissues are obviously improved. The lactobacillus reuteri CCFM1040 source extracellular vesicle provided by the invention does not generate toxic and side effects in a host body, and has a huge application prospect.

The invention discloses a composition containing cerebroprotein hydrolysate as well as a preparation method and application thereof. The composition has the main effects of improving memory, tranquilizing and allaying excitement and assisting digestion. Experiments prove that the combination of the deer brain protein hydrolysate, the pig brain protein hydrolysate and the bovine collagen peptide powder can improve the learning and memory ability of transgenic mice with Alzheimer's disease, and the combination of the deer brain protein hydrolysate, the pig brain protein hydrolysate and the bovine collagen peptide powder can further repair damaged nerve cells. The sea-buckthorn can reduce damage caused by oxygen free radicals and accelerate removal of free radicals in the body. Hawthorn and endothelium corneum gigeriae galli can improve the digestive function of a user, so that nutritional ingredients in the composition are fully absorbed by a human body. And the anti-oxidation effect of the vitamin C and the vitamin B5, the nervous system health maintaining effect of the vitamin B1, the vitamin B6 and the vitamin B12 and the carbohydrate fat protein hydrolysis accelerating effect of the vitamin B3 are supplemented, so that the whole formula composition has a certain effect of preventing the Alzheimer's disease and has a good application prospect.