72 results about "Learning memory" patented technology

The invention relates to the technical field of artificial intelligence, and provides a network intrusion detection method based on multidimensional feature collaborative analysis, and the method comprises the steps: calculating the correlation degree eta ij of any two feature columns in an original traffic feature matrix, and when eta ij is greater than eta thr, generating a new feature through Qij = Xi * Xj + (1-eta ij) * (Xi + Xj), outputting a dimension reduction feature matrix to perform nonlinear spatial transformation on the dimension reduction feature matrix X ', dynamically retrieving associated knowledge through a learnable memory library, fusing current input features and memory enhancement features, and outputting refined features; decomposing the refined features to a biological neural oscillation frequency band, applying carrier modulation, and performing feature reconstruction to generate a space-time correlation tensor; the refined features and the space-time correlation tensor are fused, and the intrusion behavior classification probability is output through multi-stage abstract compression and regularization processing; screening difficult samples based on classification confidence to construct a training library, and obtaining a conventional detection model and a special and precise detection model; and preferentially calling the special and precise model during real-time detection, and switching to the conventional model when the confidence coefficient is smaller than a confidence coefficient threshold value.

The invention discloses design and synthesis of a series of brain-targeted ginsenoside Rg1 derivatives and application of the brain-targeted ginsenoside Rg1 derivatives in treatment of Alzheimer's disease. According to the invention, ginsenoside Rg1 and polyethylene glycol with a specific chain length are covalently linked to successfully construct the derivative capable of enhancing the penetrating power of the blood-brain barrier. The series of derivatives provided by the invention not only solve the problems of poor brain targeting and insufficient stability of natural Rg1, but also can inhibit neuroinflammation by regulating and controlling an NLRP3 / caspase-1 signal channel in an LPS-induced neuroinflammation model, and finally, the learning and memory ability is remarkably improved. The product is simple and convenient in preparation process and good in biological safety, and a new candidate compound is provided for developing a new generation of Alzheimer disease treatment medicines.

The present invention discloses an active peptide capable of improving cognitive impairment, a preparation method thereof, and applications thereof. The amino acid sequence of the active peptide is shown in SEQ ID NO: 1, 2, 3, 4, 5, or 6. The present invention aims to address the problems of limited means and unstable effects of existing methods for improving cognitive impairment by providing a new active peptide, a preparation method thereof, and applications thereof. The active peptide prepared by the present invention can, to a certain extent, improve problems of impaired learning and memory and decreased cognitive function, enriching the technical approaches for improving cognitive impairment and providing new application options for related fields.

The invention is applicable to the field of food processing, and provides a preparation method of pig brain oligopeptide capable of promoting learning ability, which comprises the following steps: selecting qualified pig brain subjected to inspection and quarantine, adding clear water, stirring to prepare homogenate, heating to 90-95 DEG C, and keeping for 15 minutes; cooling the obtained tissue homogenate, and carrying out first enzymolysis; adjusting the pH value of the first enzymolysis system, standing and precipitating, separating supernate and precipitate, and adding clear water into the precipitate to re-homogenate; carrying out secondary enzymolysis on the precipitate homogenate; adjusting the pH value of the second enzymolysis system, standing and precipitating, and separating supernate and precipitate; and combining the supernatant obtained by the first enzymolysis with the supernatant obtained by the second enzymolysis, concentrating, dialyzing and drying to obtain the pig brain oligopeptide. The method is simple and convenient to operate, low in cost and high in raw material utilization rate, and the obtained product is high in purity and easy to absorb, has the physiological functions of promoting learning and memory, tonifying and strengthening the brain and the like, and has wide industrial application prospects.

The invention relates to the technical field of medicines, in particular to application of osthole in preparation of a medicine for protecting cognitive function impairment caused by down-regulation of an estrogen receptor. The OST has an improvement effect on the learning and memory ability and pathological damage of 6-month-old female peripheral ERs down-regulated mice and ER alpha- / -mouse models. The mechanism of the OST for improving learning and memory may be related to improvement of neuroplasticity, inhibition of nerve apoptosis and enhancement of neurotransmitter by regulating and controlling an estrogen-cholinergic system by the OST. The OST has a better intervention effect on a 6-month-old female ER alpha- / -mouse model, and possibly is a kidney-tonifying medicine which acts on a related target spot of a peripheral target organ so as to participate in regulation of a cognitive function of a central system.

The invention discloses a hydroxyl-alpha-sanshool nano preparation as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the hydroxyl-alpha-sanshool nano preparation is HAS-coated PEG-PLGA, the preparation method comprises the following steps: taking hydroxyl-alpha-sanshool and polyethylene glycol modified polylactic acid-glycolic acid copolymer as raw materials, and adding the hydroxyl-alpha-sanshool nano preparation and the polyethylene glycol modified polylactic acid-glycolic acid copolymer to prepare the hydroxyl-alpha-sanshool nano preparation. The preparation method comprises the following steps: preparing HAS-coated TGN-PEG-PLGA by adopting an emulsified solvent evaporation method, and further modifying by adopting TGN polypeptide, so as to prepare HAS-coated TGN-PEG-PLGA; according to the hydroxyl-alpha-sanshool nano-preparation, the encapsulation efficiency and the drug loading capacity of hydroxyl-alpha-sanshool are obviously improved, and the hydroxyl-alpha-sanshool nano-preparation has excellent stability and blood-brain barrier crossing capacity, so that the hydroxyl-alpha-sanshool nano-preparation can give full play to the treatment effects of improving learning and memory ability, cognitive ability and the like.

The invention relates to the technical field of learning and memory ability evaluation, and provides a mouse hippocampus learning and memory ability comprehensive evaluation method and system based on a Morris water maze, the method is different from a traditional method for evaluating learning and memory only through an incubation period, a mouse behavior character stability and swimming skill dual evaluation mechanism is innovatively introduced, and the method is suitable for comprehensive evaluation of learning and memory ability of a mouse hippocampus. And in combination with a training adaptation period, behavior path analysis and weighted scoring of multi-dimensional behavior indexes, precise quantification of the hippocampus dependency space learning and memory ability is realized. The experimental indexes comprise swimming speed, path length, target quadrant residence time and incubation period, and performing standardized calculation after weight assignment to generate a memory ability evaluation score. According to the invention, the scientificity, stability and experimental repeatability of an evaluation result are improved, and the method is suitable for mouse cognitive function evaluation under various research situations such as drug intervention, neurodegenerative disease models and the like.

The invention relates to the technical field of functional food, health care products and medicines, in particular to a composition for neuroprotection and cognitive function improvement and a preparation method and application thereof. The invention provides a composition for neuroprotection and cognitive function improvement. The composition is prepared from calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, by compounding the calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, the compound has a synergistic effect and can be applied to preparation of food, health care products or medicines for protecting nerves, delaying nerve aging, improving learning and memory ability, repairing nerve injury and preventing or assisting in treating neurodegenerative diseases.

The invention provides a composition for improving learning memory, spatial memory and / or cognitive functions and application thereof. The composition disclosed by the invention comprises DHA (docosahexaenoic acid) and galactose, and the mass ratio of the DHA to the galactose is 1: (8-260). The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product helpful for improving spatial memory, working memory and / or cognitive function.

The invention discloses a nutritional composition for promoting brain development and application thereof, and relates to the technical field of biological medicines. The compound composition is selected from a composition A (melatonin + uridylic acid + inositol), a composition B (melatonin + uridylic acid) and a composition C (uridylic acid + inositol). Experiments prove that the combination B can significantly improve elevated anxiety behaviors and learning and memory ability caused by rhythm disorder, the combination C can significantly improve open field anxiety behaviors caused by rhythm disorder, and the combination A can significantly relieve anxiety behaviors (including elevated and open field) and spatial learning and memory ability disorder caused by rhythm disorder at the same time. The active components in the compound composition disclosed by the invention are remarkable in synergistic effect, high in safety and good in biocompatibility, and can be used for preparing medicines, food additives or feed additives for improving rhythm disorder related brain dysplasia.

The application relates to the technical field of intelligent evaluation of medical education, in particular to a text-guided intelligent evaluation method for clinical skills based on a ranking graph constraint. The method comprises the following steps: segmenting and extracting features from a clinical skill video, pre-processing the video, combining video time sequence information and action speed text embedding to construct a time sequence feature representation, introducing skill classification text and a learnable memory embedding vector, realizing multi-modal feature decoding based on a cross-attention mechanism, outputting a skill score prediction value through a scoring network, constructing a ranking relationship matrix by using real score differences, introducing a ranking graph constraint loss and a scoring loss for joint optimization, and thus improving the accuracy and ranking consistency of skill evaluation. The application realizes accurate modeling of a clinical skill operation process and effective discrimination of relative levels between samples, thereby significantly improving the accuracy, consistency and reliability of skill evaluation.

The present application provides a kind of nutritional composition in the application of the product for improving learning, memory and cognitive ability.The nutritional composition includes animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose.Animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose can synergistically enhance the memory retention ability of the body, reduce the degree of learning and memory errors, and up-regulate the expression of oligodendrocyte transcription factor 2 coding gene, myelin basic protein coding gene and brain-derived neurotrophic factor coding gene, realize the double regulation of myelin formation and neurotrophic in hippocampus region of brain, synergistically improve the neural plasticity of central nervous system through gut-brain axis pathway, and then double improve the learning, memory and cognitive function of the body from the behavior and molecular level.

The invention discloses mRNA (messenger Ribonucleic Acid) of an m6A methylation modified Ncam1 gene and an application of the mRNA. The invention discloses mRNA (messenger ribonucleic acid) of an m6A methylation modified Ncam1 gene. A modification site is selected from adenylic acid of at least one site of the 313th site, the 617th site, the 705th site, the 769th site, the 903rd site, the 1034th site, the 1202nd site or the 1430th site of the Ncam1 gene. The application comprises the application in up-regulation of Ncam1 protein expression and the application in up-regulation of Ncam1 protein expression. Application in inhibition of neuronal aging; application in preparation of a product for treating and / or improving Alzheimer's disease; the invention relates to application in preparation of drugs for regulating learning and memory ability decline related diseases. The mRNA provided by the invention regulates self expression through the change of m6A site methylation modification level and affects synaptic related genes and neuronal aging process, so that learning and memory processes are affected, and symptoms related to AD, aging and neurodegenerative diseases are improved.

The invention discloses a multi-odor-substance learning memory training auxiliary device which comprises a base and a rotating table, a vertical cylinder is vertically and fixedly connected to the center of the top of the base, a connecting hole is formed in the outer surface of the vertical cylinder, a fan is installed at the top in the vertical cylinder, the fan is arranged at the top of the connecting hole, and an air supply mechanism is arranged in the base. The rotating table is rotationally connected to the top of the base, a round hole is vertically formed in the surface of the rotating table in a penetrating mode and formed in the outer surface of the vertical cylinder, and a plurality of connecting bases are fixedly connected to the top of the rotating table and connected with one another. According to the device disclosed by the invention, the rotating table and the plurality of connecting seats are rotationally arranged, so that each connecting port is conveniently communicated with the interior of the vertical cylinder, and the smell in each placing bottle placed in the circular groove is conveniently dissipated, so that the smell of different objects is switched, and the using effect of the device is improved; and meanwhile, the placement bottle in each circular groove is convenient to replace, so that the use convenience of the device is improved.

The invention relates to the technical field of Gaucher disease treatment, in particular to application of nicotine in preparation of drugs for relieving, adjuvant therapy or treatment of Gaucher diseases. The invention reveals for the first time that nicotine can enhance mitochondrial autophagy mediated by a PGC1 alpha / Parkin pathway by reducing accumulation of glucosylceramide and up-regulating protein expression of PGC1 alpha and Synaptophysin in a hippocampal region, also improves synaptic function and various neurotransmitter levels, enhances learning memory and application ability, and further improves neurodegenerative diseases caused by Gaucher disease.

The present invention belongs to the technical field of traditional Chinese medicine research, and particularly relates to a traditional Chinese medicine composition for treating Alzheimer's disease, its preparation method and application. The raw materials of the traditional Chinese medicine composition of the present invention and their dosages include: 5-15 parts by weight of Desmodium styracifolium, 10-15 parts by weight of Salvia przewalskii Maxim. var. kansuensis, 9-15 parts by weight of Erythrina arborescens Roxb., 8-20 parts by weight of Euphorbia hirta L., 6-12 parts by weight of Murraya exotica L., and 5-9 parts by weight of Luffa cylindrica (L.) Roem. The traditional Chinese medicine composition has the basic effects of removing dampness and promoting blood circulation to remove stasis, expelling wind and detoxifying, and promoting qi circulation and dredging collaterals. Animal experimental studies have shown that the high-dose and medium-dose of the traditional Chinese medicine composition can improve the learning ability, memory ability, learning and memory retention ability, hippocampal inflammatory mediators, β-amyloid transport enzyme gene and protein expression of Alzheimer's disease Kunming mice. At the same time, the traditional Chinese medicine composition has no effect on the main organ indexes and related body weights of Kunming mice. The proposal of the present invention provides a new technical means for further developing new traditional Chinese medicine drugs for the prevention and treatment of AD.

The application provides application of a TRPML1 specific small molecule inhibitor ML-SI3 in preparation of a drug for treating or preventing brain injury. The application has the following beneficial effects: the TRPML1 specific small molecule inhibitor ML-SI3 can significantly reduce the injury degree of neurons of a brain injury rat; the learning and memory ability of the brain injury rat is improved; the movement disorder of the brain injury rat is improved, and the brain function of a rat after cardiopulmonary resuscitation after cardiac arrest is comprehensively protected; the TRPML1 specific small molecule inhibitor ML-SI3 provides a new drug for brain function protection of a cardiac arrest patient, and has good market value and clinical application prospect.

The invention provides application of a salidroside derivative in preparation of a medicine for preventing and / or treating cognitive impairment caused by cerebrovascular lesion, and belongs to the technical field of biological medicine. The invention discloses application of a salidroside derivative SHPL-49 in preparation of a medicine for preventing and / or treating cognitive impairment caused by cerebrovascular lesion. The SHPL-49 can effectively improve the learning and memory functions after brain injury, recover the exercise coordination ability, relieve corpus callosum region myelin sheath loss above the hippocampus region and further protect the brain-sea horse region synapses. The SHPL-49 has the efficacy of treating the vascular cognitive impairment and the vascular dementia. According to the application, the medical application of the SHPL-49 is widened, and a new way is provided for treating cognitive impairment diseases caused by cerebrovascular lesion.

The invention relates to the technical field of application of natural active substances, in particular to application of octyl gallate in preparation of products for strengthening brain and improving intelligence. According to the application of the octyl gallate in preparation of the products for strengthening the brain and improving intelligence, the oxidative stress level of brain tissue and neuroinflammation response can be effectively relieved, and therefore learning and memory impairment and cognitive function decline caused by chronic sleep interference are improved. The invention finds that the octyl gallate as a polyphenol active substance has good intelligence-promoting and health-care effects, and can be used for preparing health-care foods, functional foods or nutritional supplements for improving learning memory and relieving cognitive dysfunction within a certain dosage range. The octyl gallate is clear in raw material source, can be obtained through natural extraction or chemical synthesis, and has the advantages of being high in safety, wide in application range, remarkable in economic value and the like.

This invention relates to the field of biomedical technology, specifically disclosing a cognitive impairment model, its uses, and the application of compound MT-1207 in the prevention and treatment of cognitive impairment. The structure of compound MT-1207 is shown in formula (I). This invention is the first to discover that 2K2C rats can serve as a cognitive impairment model and can be used for screening related drugs for cognitive impairment. Compound MT-1207 can improve cognitive function impairment in 2K2C rats, significantly improving the rats' movement distance, latency, number of platform crossings, and time spent in the target quadrant, and can improve the rats' learning and memory abilities.

The invention discloses application of TRPM8 in preparation of a medicine for preventing and / or treating learning and memory disorder related diseases. The application provides a new treatment target or strategy for learning and memory disorder related diseases.

The invention relates to glycopeptide for improving sleep and application thereof, and relates to the technical field of biological medicine. The glycopeptide can increase the sleep duration and improve the sleep stability, has the efficacy of improving sleep, and can also significantly improve the learning and memory ability of insomnia patients.

The present invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for improving cognitive impairment in coronary heart disease and its use. The raw materials of the composition include the following components: Alpinia oxyphylla, Lycium barbarum, Fructus schizonepetae, Lotus seed core, Panax ginseng, Ligusticum chuanxiong, and Paeonia lactiflora. The composition of the present invention can improve cardiac function and structure after acute myocardial ischemia in coronary heart disease, reduce the area of ​​ischemic myocardial infarction, alleviate myocardial cell damage and myocardial fibrosis, alleviate damage to hippocampal neurons and ultrastructural changes, and improve learning and memory functions and cognitive behavioral performance.

The invention proposes a knee joint image segmentation method, and the method comprises the steps: adding a multi-scale memory storage module to the Botleneck of each level of a U-Net network, carrying out the multi-scale feature fusion of features outputted by a corresponding layer of an encoder through the multi-scale memory storage module, carrying out the feature storage, optimization and updating of the fusion features based on an updating rule, and carrying out the segmentation of a knee joint image. And then, further fusing with the obtained fusion feature to obtain an output feature, and carrying out jumper fusion on the output feature and the decoder at the corresponding layer of the decoder, so that the extraction capability of the U-Net network on the bottom-layer feature is improved, the dependence of dissimilatory data learning on original data is reduced, and the learning and identification capability of small organs can be realized. And the learning and memory ability of different sex data is improved, and the problem of information forgetting caused by data differences is reduced.

The invention relates to the technical field of biological medicine, and particularly discloses application of ROMO1 gene in preparation of medicine for treating Alzheimer's disease. The invention finds that overexpressed ROMO1 protein can treat the Alzheimer's disease through multi-aspect experimental research, and further provides application of the ROMO1 gene in preparation of drugs for treating the Alzheimer's disease. A technician in the field can introduce the ROMO1 gene into a body through an overexpression system, so that the overexpression of the ROMO1 protein is realized; according to the present invention, the Alzheimer's disease treatment effects are provided from the aspects of learning and memory ability improving, A [beta] plaque deposition reducing, astrocyte hyperplasia reducing, microglial cell excessive activation reducing, neuronal synaptic integrity maintaining, brain mitochondrial function enhancing and the like, and the new method is provided for Alzheimer's disease treatment.

The invention is applicable to the field of medicines, and particularly relates to a rhizoma cimicifugae-containing traditional Chinese medicine composition for treating Alzheimer's disease, which comprises the following components in parts by weight: 5-15 parts of rhizoma cimicifugae, 8-12 parts of ginseng, 10-15 parts of astragalus membranaceus, 6-10 parts of salvia miltiorrhiza, 4-8 parts of rhizoma acori graminei, 3-6 parts of polygala tenuifolia, 5-8 parts of spina date seed, 10-15 parts of poria cocos, 6-10 parts of radix ophiopogonis, 12-18 parts of oyster, 8-12 parts of concha haliotidis and 4-8 parts of gastrodia elata. The cimicifugae foetidae-containing traditional Chinese medicine composition for treating the Alzheimer's disease has the beneficial effects that the cognitive function is improved: the salvia miltiorrhiza, the rhizoma acori graminei and the polygala tenuifolia can promote cerebral blood perfusion, enhance synaptic plasticity and inhibit neuronal apoptosis; the rhizoma cimicifugae and the radix astragali are combined to improve brain microcirculation and reduce beta-amyloid protein aggregation, so that the learning and memory ability is remarkably improved.

The invention belongs to the technical field of animal model establishment, and discloses an establishment method and application of a chronic oral ferric citrate induced Parkinson mouse model, C57BL / 6 mice are fed with mouse maintenance food (high-iron feed) added with 2.25% ferric citrate for 22 weeks, and then a 5% ferric citrate solution is used for intragastric administration for 4 weeks. Finally, behavioral evaluation is carried out through behavioral tests such as an open field test, a rotating rod test, a pole climbing test, a holding power test and a Y labyrinth test, and the tests such as the rotating rod test, the pole climbing test and the holding power test show that the PD model mouse has remarkable motor function impairment such as reduction of motor coordination, muscular tension and balance force; open field tests and Y maze show that learning and memory functions of mice are impaired, and cognitive impairments such as anxiety mood occur. Clinical chronic disease conditions of Parkinson's disease are simulated, and the chronic model is more suitable for monitoring early changes and screening early diagnosis indexes of Parkinson's disease; the method has the characteristics that the behavioral disorder can be quantified, and DA energy neuron degeneration loss characteristic lesion is realized.

The application discloses a learning and memory training auxiliary device for multiple odor substances, which comprises a base and a rotating table. A vertical cylinder is fixedly connected to the center of the top of the base in a vertical mode. A connecting hole is formed in the outer surface of the vertical cylinder. A fan is installed at the top of the vertical cylinder. The fan is arranged at the top of the connecting hole. An air supply mechanism is arranged in the base. The rotating table is rotatably connected to the top of the base. A circular hole is vertically formed in the surface of the rotating table. The circular hole is arranged on the outer surface of the vertical cylinder. A plurality of connecting seats are fixedly connected to the top of the rotating table. The plurality of connecting seats are connected to each other. The rotating table and the plurality of connecting seats are arranged in a rotating mode, so that each connecting port is communicated with the inside of the vertical cylinder, and the odor in each placing bottle placed in the circular groove is easily radiated, thereby switching the odors of different objects, improving the use effect of the device, and facilitating the replacement of the placing bottles in each circular groove, thereby improving the use convenience of the device.

The invention discloses an AD rat model imaging experiment method, a QSM graph construction method and QSM application, which can be used for researching pathological protein change in a hippocampus area. The rat model imaging experiment method comprises the following steps: (I) respectively injecting equal amounts of A [beta] 1-40 and PBS solutions into hippocampus CA1 regions on two sides of an SD rat to construct an A [beta]-induced AD rat model G1 and a control group G2; (II) replacing an A beta sequence in a rat App gene and mutation sites around the A beta sequence with a human source sequence; (III) evaluating the spatial orientation learning and memory ability of the rat by using a Morris water maze experiment which is carried out for 6 days in total and is divided into two stages: the first stage is a platform hiding stage test for 5 days; and the second stage is a platform-free space exploration stage test for one day.

The invention discloses application of fenofibrate to improvement of learning and memory ability decline caused by a microgravity effect. Experiments show that fenofibrate can effectively improve the reduction of the spatial memory ability of a mouse with a suspended tail. Experimental results show that fenofibrate has the value of being developed into drugs for preventing and treating related learning and memory ability decline.