53 results about "Learning memory" patented technology

The invention discloses design and synthesis of a series of brain-targeted ginsenoside Rg1 derivatives and application of the brain-targeted ginsenoside Rg1 derivatives in treatment of Alzheimer's disease. According to the invention, ginsenoside Rg1 and polyethylene glycol with a specific chain length are covalently linked to successfully construct the derivative capable of enhancing the penetrating power of the blood-brain barrier. The series of derivatives provided by the invention not only solve the problems of poor brain targeting and insufficient stability of natural Rg1, but also can inhibit neuroinflammation by regulating and controlling an NLRP3 / caspase-1 signal channel in an LPS-induced neuroinflammation model, and finally, the learning and memory ability is remarkably improved. The product is simple and convenient in preparation process and good in biological safety, and a new candidate compound is provided for developing a new generation of Alzheimer disease treatment medicines.

The invention relates to the technical field of medicines, in particular to application of osthole in preparation of a medicine for protecting cognitive function impairment caused by down-regulation of an estrogen receptor. The OST has an improvement effect on the learning and memory ability and pathological damage of 6-month-old female peripheral ERs down-regulated mice and ER alpha- / -mouse models. The mechanism of the OST for improving learning and memory may be related to improvement of neuroplasticity, inhibition of nerve apoptosis and enhancement of neurotransmitter by regulating and controlling an estrogen-cholinergic system by the OST. The OST has a better intervention effect on a 6-month-old female ER alpha- / -mouse model, and possibly is a kidney-tonifying medicine which acts on a related target spot of a peripheral target organ so as to participate in regulation of a cognitive function of a central system.

The invention discloses a hydroxyl-alpha-sanshool nano preparation as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the hydroxyl-alpha-sanshool nano preparation is HAS-coated PEG-PLGA, the preparation method comprises the following steps: taking hydroxyl-alpha-sanshool and polyethylene glycol modified polylactic acid-glycolic acid copolymer as raw materials, and adding the hydroxyl-alpha-sanshool nano preparation and the polyethylene glycol modified polylactic acid-glycolic acid copolymer to prepare the hydroxyl-alpha-sanshool nano preparation. The preparation method comprises the following steps: preparing HAS-coated TGN-PEG-PLGA by adopting an emulsified solvent evaporation method, and further modifying by adopting TGN polypeptide, so as to prepare HAS-coated TGN-PEG-PLGA; according to the hydroxyl-alpha-sanshool nano-preparation, the encapsulation efficiency and the drug loading capacity of hydroxyl-alpha-sanshool are obviously improved, and the hydroxyl-alpha-sanshool nano-preparation has excellent stability and blood-brain barrier crossing capacity, so that the hydroxyl-alpha-sanshool nano-preparation can give full play to the treatment effects of improving learning and memory ability, cognitive ability and the like.

The invention relates to the technical field of learning and memory ability evaluation, and provides a mouse hippocampus learning and memory ability comprehensive evaluation method and system based on a Morris water maze, the method is different from a traditional method for evaluating learning and memory only through an incubation period, a mouse behavior character stability and swimming skill dual evaluation mechanism is innovatively introduced, and the method is suitable for comprehensive evaluation of learning and memory ability of a mouse hippocampus. And in combination with a training adaptation period, behavior path analysis and weighted scoring of multi-dimensional behavior indexes, precise quantification of the hippocampus dependency space learning and memory ability is realized. The experimental indexes comprise swimming speed, path length, target quadrant residence time and incubation period, and performing standardized calculation after weight assignment to generate a memory ability evaluation score. According to the invention, the scientificity, stability and experimental repeatability of an evaluation result are improved, and the method is suitable for mouse cognitive function evaluation under various research situations such as drug intervention, neurodegenerative disease models and the like.

The invention relates to the technical field of functional food, health care products and medicines, in particular to a composition for neuroprotection and cognitive function improvement and a preparation method and application thereof. The invention provides a composition for neuroprotection and cognitive function improvement. The composition is prepared from calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, by compounding the calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, the compound has a synergistic effect and can be applied to preparation of food, health care products or medicines for protecting nerves, delaying nerve aging, improving learning and memory ability, repairing nerve injury and preventing or assisting in treating neurodegenerative diseases.

The invention provides a composition for improving learning memory, spatial memory and / or cognitive functions and application thereof. The composition disclosed by the invention comprises DHA (docosahexaenoic acid) and galactose, and the mass ratio of the DHA to the galactose is 1: (8-260). The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product helpful for improving spatial memory, working memory and / or cognitive function.

The invention discloses a nutritional composition for promoting brain development and application thereof, and relates to the technical field of biological medicines. The compound composition is selected from a composition A (melatonin + uridylic acid + inositol), a composition B (melatonin + uridylic acid) and a composition C (uridylic acid + inositol). Experiments prove that the combination B can significantly improve elevated anxiety behaviors and learning and memory ability caused by rhythm disorder, the combination C can significantly improve open field anxiety behaviors caused by rhythm disorder, and the combination A can significantly relieve anxiety behaviors (including elevated and open field) and spatial learning and memory ability disorder caused by rhythm disorder at the same time. The active components in the compound composition disclosed by the invention are remarkable in synergistic effect, high in safety and good in biocompatibility, and can be used for preparing medicines, food additives or feed additives for improving rhythm disorder related brain dysplasia.

The application relates to the technical field of intelligent evaluation of medical education, in particular to a text-guided intelligent evaluation method for clinical skills based on a ranking graph constraint. The method comprises the following steps: segmenting and extracting features from a clinical skill video, pre-processing the video, combining video time sequence information and action speed text embedding to construct a time sequence feature representation, introducing skill classification text and a learnable memory embedding vector, realizing multi-modal feature decoding based on a cross-attention mechanism, outputting a skill score prediction value through a scoring network, constructing a ranking relationship matrix by using real score differences, introducing a ranking graph constraint loss and a scoring loss for joint optimization, and thus improving the accuracy and ranking consistency of skill evaluation. The application realizes accurate modeling of a clinical skill operation process and effective discrimination of relative levels between samples, thereby significantly improving the accuracy, consistency and reliability of skill evaluation.

The present application provides a kind of nutritional composition in the application of the product for improving learning, memory and cognitive ability.The nutritional composition includes animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose.Animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose can synergistically enhance the memory retention ability of the body, reduce the degree of learning and memory errors, and up-regulate the expression of oligodendrocyte transcription factor 2 coding gene, myelin basic protein coding gene and brain-derived neurotrophic factor coding gene, realize the double regulation of myelin formation and neurotrophic in hippocampus region of brain, synergistically improve the neural plasticity of central nervous system through gut-brain axis pathway, and then double improve the learning, memory and cognitive function of the body from the behavior and molecular level.

The invention discloses mRNA (messenger Ribonucleic Acid) of an m6A methylation modified Ncam1 gene and an application of the mRNA. The invention discloses mRNA (messenger ribonucleic acid) of an m6A methylation modified Ncam1 gene. A modification site is selected from adenylic acid of at least one site of the 313th site, the 617th site, the 705th site, the 769th site, the 903rd site, the 1034th site, the 1202nd site or the 1430th site of the Ncam1 gene. The application comprises the application in up-regulation of Ncam1 protein expression and the application in up-regulation of Ncam1 protein expression. Application in inhibition of neuronal aging; application in preparation of a product for treating and / or improving Alzheimer's disease; the invention relates to application in preparation of drugs for regulating learning and memory ability decline related diseases. The mRNA provided by the invention regulates self expression through the change of m6A site methylation modification level and affects synaptic related genes and neuronal aging process, so that learning and memory processes are affected, and symptoms related to AD, aging and neurodegenerative diseases are improved.

The invention discloses a multi-odor-substance learning memory training auxiliary device which comprises a base and a rotating table, a vertical cylinder is vertically and fixedly connected to the center of the top of the base, a connecting hole is formed in the outer surface of the vertical cylinder, a fan is installed at the top in the vertical cylinder, the fan is arranged at the top of the connecting hole, and an air supply mechanism is arranged in the base. The rotating table is rotationally connected to the top of the base, a round hole is vertically formed in the surface of the rotating table in a penetrating mode and formed in the outer surface of the vertical cylinder, and a plurality of connecting bases are fixedly connected to the top of the rotating table and connected with one another. According to the device disclosed by the invention, the rotating table and the plurality of connecting seats are rotationally arranged, so that each connecting port is conveniently communicated with the interior of the vertical cylinder, and the smell in each placing bottle placed in the circular groove is conveniently dissipated, so that the smell of different objects is switched, and the using effect of the device is improved; and meanwhile, the placement bottle in each circular groove is convenient to replace, so that the use convenience of the device is improved.

The invention relates to the technical field of Gaucher disease treatment, in particular to application of nicotine in preparation of drugs for relieving, adjuvant therapy or treatment of Gaucher diseases. The invention reveals for the first time that nicotine can enhance mitochondrial autophagy mediated by a PGC1 alpha / Parkin pathway by reducing accumulation of glucosylceramide and up-regulating protein expression of PGC1 alpha and Synaptophysin in a hippocampal region, also improves synaptic function and various neurotransmitter levels, enhances learning memory and application ability, and further improves neurodegenerative diseases caused by Gaucher disease.

The application provides application of a TRPML1 specific small molecule inhibitor ML-SI3 in preparation of a drug for treating or preventing brain injury. The application has the following beneficial effects: the TRPML1 specific small molecule inhibitor ML-SI3 can significantly reduce the injury degree of neurons of a brain injury rat; the learning and memory ability of the brain injury rat is improved; the movement disorder of the brain injury rat is improved, and the brain function of a rat after cardiopulmonary resuscitation after cardiac arrest is comprehensively protected; the TRPML1 specific small molecule inhibitor ML-SI3 provides a new drug for brain function protection of a cardiac arrest patient, and has good market value and clinical application prospect.

The invention relates to the technical field of application of natural active substances, in particular to application of octyl gallate in preparation of products for strengthening brain and improving intelligence. According to the application of the octyl gallate in preparation of the products for strengthening the brain and improving intelligence, the oxidative stress level of brain tissue and neuroinflammation response can be effectively relieved, and therefore learning and memory impairment and cognitive function decline caused by chronic sleep interference are improved. The invention finds that the octyl gallate as a polyphenol active substance has good intelligence-promoting and health-care effects, and can be used for preparing health-care foods, functional foods or nutritional supplements for improving learning memory and relieving cognitive dysfunction within a certain dosage range. The octyl gallate is clear in raw material source, can be obtained through natural extraction or chemical synthesis, and has the advantages of being high in safety, wide in application range, remarkable in economic value and the like.

This invention relates to the field of biomedical technology, specifically disclosing a cognitive impairment model, its uses, and the application of compound MT-1207 in the prevention and treatment of cognitive impairment. The structure of compound MT-1207 is shown in formula (I). This invention is the first to discover that 2K2C rats can serve as a cognitive impairment model and can be used for screening related drugs for cognitive impairment. Compound MT-1207 can improve cognitive function impairment in 2K2C rats, significantly improving the rats' movement distance, latency, number of platform crossings, and time spent in the target quadrant, and can improve the rats' learning and memory abilities.

The invention relates to glycopeptide for improving sleep and application thereof, and relates to the technical field of biological medicine. The glycopeptide can increase the sleep duration and improve the sleep stability, has the efficacy of improving sleep, and can also significantly improve the learning and memory ability of insomnia patients.

The invention proposes a knee joint image segmentation method, and the method comprises the steps: adding a multi-scale memory storage module to the Botleneck of each level of a U-Net network, carrying out the multi-scale feature fusion of features outputted by a corresponding layer of an encoder through the multi-scale memory storage module, carrying out the feature storage, optimization and updating of the fusion features based on an updating rule, and carrying out the segmentation of a knee joint image. And then, further fusing with the obtained fusion feature to obtain an output feature, and carrying out jumper fusion on the output feature and the decoder at the corresponding layer of the decoder, so that the extraction capability of the U-Net network on the bottom-layer feature is improved, the dependence of dissimilatory data learning on original data is reduced, and the learning and identification capability of small organs can be realized. And the learning and memory ability of different sex data is improved, and the problem of information forgetting caused by data differences is reduced.

The invention relates to the technical field of biological medicine, and particularly discloses application of ROMO1 gene in preparation of medicine for treating Alzheimer's disease. The invention finds that overexpressed ROMO1 protein can treat the Alzheimer's disease through multi-aspect experimental research, and further provides application of the ROMO1 gene in preparation of drugs for treating the Alzheimer's disease. A technician in the field can introduce the ROMO1 gene into a body through an overexpression system, so that the overexpression of the ROMO1 protein is realized; according to the present invention, the Alzheimer's disease treatment effects are provided from the aspects of learning and memory ability improving, A [beta] plaque deposition reducing, astrocyte hyperplasia reducing, microglial cell excessive activation reducing, neuronal synaptic integrity maintaining, brain mitochondrial function enhancing and the like, and the new method is provided for Alzheimer's disease treatment.

The invention belongs to the technical field of animal model establishment, and discloses an establishment method and application of a chronic oral ferric citrate induced Parkinson mouse model, C57BL / 6 mice are fed with mouse maintenance food (high-iron feed) added with 2.25% ferric citrate for 22 weeks, and then a 5% ferric citrate solution is used for intragastric administration for 4 weeks. Finally, behavioral evaluation is carried out through behavioral tests such as an open field test, a rotating rod test, a pole climbing test, a holding power test and a Y labyrinth test, and the tests such as the rotating rod test, the pole climbing test and the holding power test show that the PD model mouse has remarkable motor function impairment such as reduction of motor coordination, muscular tension and balance force; open field tests and Y maze show that learning and memory functions of mice are impaired, and cognitive impairments such as anxiety mood occur. Clinical chronic disease conditions of Parkinson's disease are simulated, and the chronic model is more suitable for monitoring early changes and screening early diagnosis indexes of Parkinson's disease; the method has the characteristics that the behavioral disorder can be quantified, and DA energy neuron degeneration loss characteristic lesion is realized.

The application discloses a learning and memory training auxiliary device for multiple odor substances, which comprises a base and a rotating table. A vertical cylinder is fixedly connected to the center of the top of the base in a vertical mode. A connecting hole is formed in the outer surface of the vertical cylinder. A fan is installed at the top of the vertical cylinder. The fan is arranged at the top of the connecting hole. An air supply mechanism is arranged in the base. The rotating table is rotatably connected to the top of the base. A circular hole is vertically formed in the surface of the rotating table. The circular hole is arranged on the outer surface of the vertical cylinder. A plurality of connecting seats are fixedly connected to the top of the rotating table. The plurality of connecting seats are connected to each other. The rotating table and the plurality of connecting seats are arranged in a rotating mode, so that each connecting port is communicated with the inside of the vertical cylinder, and the odor in each placing bottle placed in the circular groove is easily radiated, thereby switching the odors of different objects, improving the use effect of the device, and facilitating the replacement of the placing bottles in each circular groove, thereby improving the use convenience of the device.

The invention provides a composition for improving learning memory and / or cognitive function and application thereof. The composition provided by the invention comprises alpha-choline glycerophosphate and galactose, and the mass ratio of the alpha-choline glycerophosphate to the galactose is 1: (8-100). The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product helpful for improving learning memory and / or cognitive functions.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a thyroid function regulation and control preparation based on an astragalus membranaceus fermentation extract and a preparation method thereof, and the preparation is technically characterized in that the preparation takes an extract obtained after astragalus membranaceus is fermented by specific microorganisms (such as lactobacillus plantarum) as an active ingredient. Systematic iodine deficiency rat model experiments prove that the fermentation extract has obviously better effects in the aspects of improving thyroid functions and forms (such as adjusting FT3, FT4, TSH and TPO-Ab), enhancing body antioxidant ability (such as improving activity of SOD and CAT of hippocampus and liver) and improving learning and memory behaviors than a traditional astragalus extract. The invention provides an effective scheme for developing an innovative traditional Chinese medicine preparation for comprehensively preventing and treating the iodine deficiency thyroid disease and complications thereof.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a tryptamine compound, a preparation method thereof and application of the tryptamine compound in preparation of a medicine for enhancing learning and memory. The tryptamine compound provided by the invention has a structure as shown in formula 1. The tryptamine compound with the structure as shown in the formula 1 provided by the invention can simultaneously excite a Sigma-1 receptor and a 5-HT2A receptor to play a role, is a dual agonist of the Sigma-1 receptor and the 5-HT2A receptor, and shows the effects of complementing action mechanisms, synergistically enhancing neuroprotection, expanding the action brain region range and reducing side effects. Compared with a traditional medicine for enhancing the learning and memory ability, the tryptamine compound with the structure as shown in the formula 1 has the function of remarkably improving the learning and memory activity. Formula 1.

The present application relates to the use of Bacillus coagulans BC99 in the preparation of a preparation for improving sarcopenia; the Bacillus coagulans BC99 is a Bacillus coagulans strain with the preservation number of CGMCC No.21801. The present application develops a new microbial strategy for improving sarcopenia, and the present application creatively finds that the Bacillus coagulans BC99 can promote muscle synthesis of a sarcopenia rat model, improve gastrocnemius index, and increase ATP content in skeletal muscle and myocardium; can improve muscle function of the sarcopenia rat model and improve its exercise capacity; can improve the learning and memory function decline symptoms of the sarcopenia rat model; and can improve free radical damage of the sarcopenia rat model. The present application also provides a new idea for the wide application of the Bacillus coagulans BC99 strain.

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative for neurodegenerative diseases, a pharmaceutical composition and application of the piperidine derivative. The piperidine derivative has a structure shown in a general formula (I). In-vivo experiments prove that the compound can effectively improve learning and memory impairment of beta-amyloid protein induced Alzheimer disease model rats, the escape latency is remarkably shortened and the ring penetration frequency is increased in a Morris water maze test, and the behavioral improvement effect of the compound is remarkably superior to that of carristine and can be compared favorably with that of a positive control drug. Meanwhile, the series of compounds can significantly inhibit abnormally increased acetylcholin esterase activity in hippocampal tissues of model rats, have an excellent regulation effect on cholinergic system functions, and show a synergistic effect of cognitive improvement and key pathological link regulation. The compound provided by the invention provides a new and potential candidate drug for treatment of Alzheimer's disease.

The present application belongs to the technical field of pharmaceutical compositions, and particularly relates to a composition containing yak milk fat globule membrane and capable of improving cognitive function decline and application thereof. The composition takes yak milk fat globule membrane as a core active ingredient, and takes taurine, selenium-rich yeast and yam extract as auxiliary active ingredients. Through synergistic effect of the components, the composition can target inhibit acetylcholinesterase activity, relieve oxidative stress damage of brain nerve cells, reduce the level of pro-inflammatory factors in the brain, and then significantly improve cognitive function. The composition takes into account functionality and nutrition, and shows broad application prospects in the development of products related to improving learning and memory ability, delaying cognitive function decline and improving cognitive impairment.

The invention provides a neuroprotective effect of DIRAS1 on Alzheimer's disease (AD), and belongs to the technical field of biological medicine. The invention provides application of a reagent for overexpressing a DIRAS1 gene in preparation of a medicine for preventing and / or treating AD by taking the DIRAS1 gene as a therapeutic target of AD. The treatment of a model mouse in the embodiment finds that the DIRAS1 gene is over-expressed in the brain of the AD mouse, and the cognitive function detection finds that the recognition memory, the working memory and the long-term spatial learning memory of the AD mouse can be remarkably improved; morphological and molecular biological detection finds that deposition of A beta and excessive phosphorylation of Tau protein are reduced, and Golgi staining and western blot detection finds that damage to a synaptic structure is reduced and expression of synaptic related protein is increased. Therefore, the cognitive function, pathological characteristics and synaptic plasticity of AD mice can be improved by a method of overexpressing the DIRAS1 gene.

The application provides a composition for improving learning memory and / or cognitive function and application thereof. The composition of the application comprises alpha-glycerophosphocholine and galactose, wherein the mass ratio of the alpha-glycerophosphocholine to the galactose is 1:(8-100).

The application belongs to the field of biological medicine and microecological intervention technology, and relates to application of Bacillus coagulans T-21 in reducing ulcerative colitis combined with cognitive dysfunction. A dextran sodium sulfate (DSS) induced mouse ulcerative colitis combined with cognitive dysfunction model is established by taking a Bacillus coagulans T-21 strain as an active ingredient, and an intervention effect is evaluated. Results show that the Bacillus coagulans T-21 intervention can improve the cognitive related behavior performance and learning and memory ability of the model mice, thereby reducing ulcerative colitis related cognitive dysfunction. Meanwhile, the Bacillus coagulans T-21 intervention can increase the colon length, up-regulate the expression of tight junction proteins Occludin, Claudin-1 and Claudin-5 in colon tissue, improve the intestinal mucosal barrier damage, and down-regulate the expression levels of pro-inflammatory factors IL-1beta in colon tissue and IL-6 in hippocampus tissue, thereby reducing intestinal and central inflammatory reactions.

Aspects of the invention are directed to methods of stimulating or promoting neurogenesis by administering to a subject of a composition comprising a cyclodextrin and a polyethylene glycol to alleviate learning, memory and cognitive deficits present in subjects afflicted with various brain disorders or from neurodegenerative disorder associated with aging.