52 results about "Cerebrovascular lesion" patented technology

The invention discloses a three-dimensional brain blood vessel model construction method based on a tree structure. The method includes the following steps: firstly, acquiring a three-dimensional brain blood vessel body data field from CT or MRA equipment; separating the brain blood vessel from background noise through a partitioning algorithm; secondly, calculating the skeleton line of the brain blood vessels, and building a tree-shaped brain blood vessel topological structure as per the skeleton line structure; next, calculating out the radius of the brain blood vessel at each control point through the elastic ball algorithm as per the skeleton line; and finally, three-dimensionally displaying the built brain blood vessels adopting the tree-shaped structure. The construction method provided by the invention accords with information of the space topological structure for brain blood vessels, and has the advantages of high vessel display precision and small result error; and the vessel lesion area can be detected, and the mapping in a multi-scale manner with respect to display windows of different sizes can be realized.

The invention discloses a novel Chinese medicinal composition for treating hypertension and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: amur corktree bark, baical skullcap root, golden thread, lightyellow sophora root, figwort root, gypsum, anemarrhena asphodeloides bunge, gardenia, Mongolian snakegourd root, root of red-rooted salvia, prepared rhubarb, kudzu-vine root, radix rehmanniae preparata, medlar, dendrobium, fragrant solomonseal rhizome, common lophatherum herb, reed rhizome, cassia seed, tree peony bark, red paeony root, Sinkiang arnebia root, honeysuckle flower, dandelion, philippine violet herb, glabrous greenbrier rhizome, Chinese lobelia herb, cortex lycii radicis, starwort root, figwortflower picrorhiza rhizome and the like. The Chinese medicinal composition can be prepared into any common oral preparation by the conventional Chinese medicinal preparation method. The Chinese medicinal composition can obviously improve symptoms such as elevation of blood pressure, dizzy head and vision, numb limbs, elevation of blood fat and blood viscosity, and cardiovascular and cerebrovascular diseases caused by the hypertension. The Chinese medicinal composition has the advantages of exact clinical effects, obvious curative effect, quick response, low cost, basically no toxic or side effects and the like.

The invention discloses a catheter polarization-sensitive optical coherence tomography system and a demodulation method. The system is characterized in that a fast scanning light source is used as a light source in the system, a polarization maintaining fiber is used to generate delay of an orthogonal polarization state in the system, polarization diversity acquisition is carried out by a polarization beam splitter, and polarization diversity imaging of two orthogonal input polarization states is simultaneously appeared in one image. In the demodulation method, a series of steps such as polarization leveling, background signal cancellation, spectral shaping, dual-state dispersion cancellation, interpolation Fourier transform, reference surface selection, polarization solution, and conversion of a polar coordinate to a Cartesian coordinate are carried out to finally realize vascular birefringence imaging. According to the system and demodulation method, the vascular birefringence information can be obtained, and more characteristic information for cardiovascular and cerebrovascular diseases is provided.

The invention discloses a total-nutrient multifunctional compound hippophae rhamnoides and pine pollen health-care product, which is prepared by mixing 20 to 80 weight percent of hippophae rhamnoides, 20 to 80 weight percent of natto, 1 to 15 weight percent of tea polyphenol and 2 to 20 weight percent of resveratrol, wherein the weight percentage ratio of medicaments to auxiliary materials is 20-80 weight percent: 80-20 weight percent. The health-care product can be formed into capsules, tablets, chewable tablet, grains, oral liquid and soft capsules. The product offers remarkable health-care effects through properties of treating cerebral and vascular diseases, endocrinopathy, digestive system diseases and nervous system diseases, preventing and curing cancers, improving immunity, resisting bacteria, diminishing inflammation, resisting oxidization, radiation, osteoporosis and aging, reducing weight, skin beautifying, and the like. The product has an active social and economic significance in terms of disease prevention, body building and industrial promotion realization.

The invention provides application of peroxidase Prdx1 (peroxiredoxin-1) to preparation of a drug for preventing and treating cerebral injury diseases based on cerebral arterial thrombosis, vascular dementia and other cerebrovascular diseases. According to the invention, a Prdx1 gene-carrying overexpression plasmid and a recombinant lentiviral vector are established, cell and whole animal level tests prove that the Prdx1 is capable of effectively reversing the ischemic injury of vascular endothelial cells, protecting a BBB (Blood Brain Barrier) and relieving nerve function deficits caused by cerebral microcirculatory disturbance, and therefore, the effect of preventing and treating the cerebrovascular diseases is achieved. The Prdx1 gene lentiviral vector provided by the invention is expected to become an important way for developing the drug for treating the cerebrovascular diseases, and experimental basis is provided to the application of the Prdx1 gene to gene therapy of the cerebrovascular diseases.

Disclosed is a Chinese medicinal preparation for the treatment and prevention of diabetes and angiopathy, wherein the active compositions include nine kinds of medicinal ingredients (by weight portions) including, cornus officinalis 2-15 parts, dried rehmannia root 1-12 parts, astragalus root 5-30 parts, motherwort 4-20 parts, winged euony twigs 2-10 parts, baikal skullcap root 3-15 parts, sophora flower 2-8 parts, batryticated silkworm 2-10 parts, emblic leafflower fruit 1-4 parts. The new dosage types of the medicinal preparation include capsule.

The invention discloses a traditional Chinese preparation for regulating blood sugar, which belongs to the field of traditional Chinese medicament. The traditional Chinese preparation is prepared by the main materials of the weights as follows: 10g of poria cum ligno hospite, 10g of kudzu roots, 10g of mulberry leaves, 8g of Chinese date, and 10g of bamboo leaves. The health-care food for regulating blood sugar is natural, has no toxic and side effects, and greatly improves the bidirectional blood sugar regulation effect on diabetics, thereby having protecting effects on a series of complicating diseases such as cardiac, cerebral and vascular pathological changes, nephropathy, pathological changes of cataract, diabetic retinopathy and various infections caused by diabetes.

A health-care food in the form of tablet, particle, or capsule for the prevention and adjuvant treatment of hyperlipemia, hypertension, constipation and cardiovascular and cerebrovascular diseases is prepared proportionally from cassia seed, haw, wheat bran, rebaudiose, etc. Its preparing process is also disclosed.

The invention relates to a traditional Chinese medicine, in particular to a medicament for treating wind-caused dizziness. The medicament solves the problem on treatment of wind-caused dizziness and is prepared from the following medicaments: white mustard seed, tall gastrodia tuber, pinellia tuber, sojutsu var, giant typhonium rhizome, red ochre, acorus root, magnetite, szechuan lovage rhizome, Chinese angelica, cicada slough, golden thread, crude dragon bone, raw oyster shell, gardenia fruit, baical skullcap root, tangerine peel, red tangerine peel, chrysanthemum flower, white paeony root, scrophularia, danshen root, medicinal cyathula root, mint, earthworm and liquorice root. The traditional Chinese medicine is mainly used for treating dizziness caused by cardiovascular and cerebrovascular diseases such as high blood pressure, hyperlipidemia and the like, dizziness caused by blood supply insufficiency, tinnitus-caused dizziness, dizziness caused by Meniere's syndrome, dizziness caused by cervical spondylosis and the like.

The invention relates to novel medical anti-hypertension compound slow release tablets. The tablets are mainly prepared from four bioactive components of 5 mg-20 mg of quercetin, 5 mg-20 mg of pinoresinol diglucoside (effective ingredient of the bark of eucommia), 0.4 mg-1.60 mg of sulfonamide diuretic indapamide and 2 mg-10 mg of angiotensin reductase II inhibitor (ACEI) perindopril salt and pharmaceutical adjuvants of 20 mg-60 mg of PVP-k30, 10 mg-30 mg of hydroxyl propyl cellulose (HPMC-K15M), 30 mg-60 mg of lactose, 53 mg-80 mg of microcrystalline cellulose (MCC), 1 mg-2 mg of magnesium stearate (lubricating agent), 2 mg-4 mg of low hydroxypropyl cellulose (LHPC, disintegrating agent), 1 mg-20 mg of starch and 1 mg-10 mg of talcum powder. The novel anti-hypertension compound slow release tablets provide a safe and effective medicine help for adjusting and stabilizing blood pressure of patients, improving heart functions, relieving heart and cerebral vessel lesions and avoiding occurrence of other cardiovascular disease risks.

The invention provides a sunflower oil emulsion characterized by consisting of, by mass, sunflower oil 10-45%, solvent 37-57%, emulsifier 15-30%, perfume 0.5-1.5%, flavouring 0.5-1.5%, and antiseptic 0.5-1.5%. The preparation method includes following steps: adding sunflower oil into a mixing kettle at normal temperature; adding solvent in proportion; stirring and dissolving; adding emulsifier, perfume, flavouring and antiseptic successively in proportion; fully stirring and mixing uniformly. The sunflower oil emulsion containing 10-45% sunflower oil can prevent and treat cataract and cardio cerebrovascular illnesses, and has characteristics of good mouthfeel, high bioavailability, and convenient usage. Moreover, the sunflower oil emulsion can develop and utilize the soybean resources to produce the natural beverage, in order to meet the demand of natural plant beverage at home and abroad.

The embodiment of the invention discloses a heart and cerebral vasculopathy double-factor judgment system based on an ultrasonic image. The heart and cerebral vasculopathy double-factor judgment system comprises a carotid artery average intima-media membrane cross section area obtaining module, a blood vessel stiffness degree obtaining module and a lesion prognosis module. The lesion prognosis module conducts quantitative evaluation on heart and cerebral vasculopathy according to the average intima-media membrane cross section area obtained through the carotid artery average intima-media membrane cross section area obtaining module and the blood vessel stiffness degree obtained through the blood vessel stiffness degree obtaining module. When the heart and cerebral vasculopathy double-factor judgment system is used, the average intima-media membrane cross section area obtaining module obtains the thickness of the wall of the carotid artery blood vessel through the B ultrasound, the blood vessel stiffness degree is obtained through the blood vessel stiffness degree obtaining module, objective evaluation and prognosis are conducted through a model of the lesion prognosis module, rapid, efficient and objective initial screening can be conducted on heart and cerebral vasculopathy, a doctor can conduct secondary judgment on the result provided by the model on the basis of the system, and therefore the diagnosis efficiency is greatly improved, and detection omission and misdiagnosis are avoided.

The invention provides soybean oil emulsion which is characterized by being composed of the following components by mass fraction: 10%-45% of soybean oil, 37%-57% of a solvent, 15%-30% of an emulgator, 0.5%-1.5% of an aromatic, 0.5%-1.5% of a corrigent and 0.5%-1.5% of an aseptic. A preparation method comprises the following steps: firstly adding soybean oil to a modulation kettle at an ambient temperature condition, then adding the solvent according to proportion, stirring for dissolving, then sequentially adding the emulgator, the aromatic, the corrigent and the aseptic according to a proportion, and sufficiently stirring for uniformly mixing. The soybean oil emulsion can be used for preventing and curing cataract and cardiac cerebrovascular diseases and is good in taste, high in bioavailability and convenient to use. A method for producing a natural drink from a soybean resource can be developed to meet requirements of domestic and foreign markets on natural plant drinks.

The invention discloses a composition for adjusting hyperlipemia. The composition comprises the following substances in parts by weight: 10-30 parts of purple coneflower leaves, 20-50 parts of star anise, 15-35 parts of alfalfa, 1-5 parts of ostrich oil, 1-8 parts of pumpkin, 1-8 parts of caraway and 200-800 parts of buckwheat husks. The composition for adjusting hyperlipemia disclosed by the invention has a very good adjusting effect, is free of any substance causing side effect, safe and reliable, easily available in material resource, and low in cost. The composition disclosed by the invention also has the effects of activating blood circulation to dissipate stasis, preventing heart and cerebral vessel lesion and the like.

The embodiment of the invention discloses a self-expanded stent which has a hollow tubular meshed structure; stent rod pieces are arranged at the periphery of a mesh; and every two adjacent stent rod pieces can form a closed mesh. In the embodiment of the invention, the cerebrovascular stent is in the hollow tubular type, has the uniform mesh structure and is conveyed to the cerebrovascular disease position, the narrow disease position is released through a conveying rod to be expanded so that a blood vessel flowing channel is rebuilt; as the structural design has the uniform continuous closed mesh structure, every two adjacent rod pieces can form the closed mesh to cover stenosis plaque uniformly and continuously so as to provide uniform annular supporting force, and particularly at the bent blood vessel, the rod pieces can be closed to form a continuous lumen channel.

The invention relates to a multifunctional intracranial hematoma removing device, and belongs to the technical field of intracranial hematoma removing medical apparatuses. The multifunctional intracranial hematoma removing device is formed by a device body, a guiding rod and a visible device. A water injection pipe, a medicine injection pipe and two drainage liquid sucking pipes are manufactured in the cylindrical wall of the device body, and the four pipes are evenly distributed on the circumference of the device body at 90 degrees; slant injection holes and a center through hole are manufactured in the bottom of the device body, and two lighting devices are installed. After the guiding rod is drawn out of the device body, the visible device connected with a computer terminal can be installed in a cylinder. According to the multifunctional intracranial hematoma removing device, the multiple functions of sludged blood smashing, blood sucking, flushing draining, medicine injection and lighting are integrated, a hematoma removing operation can be completed with one device, the intracranial pressure can be effectively reduced, and the operation time is short. The problems that an existing minimally-invasive removing device is single in function and long in operation time, and does not have the lighting function, brain blood vessel lesions cannot be found in the early stage, and disease future trouble of a patient is left are solved.

The invention discloses a perindopril amlodipine tablet and a production process thereof. The tablet comprises the following components: perindopril tert-butylamine salt, amlodipine besylate, microcrystalline cellulose, lactose, pregelatinized starch, sodium carboxymethyl starch, magnesium stearate, silicon dioxide and talc powder. The perindopril amlodipine tablet is an effective, safe and convenient treatment medicament for hypertension patients, and has important meaning in controlling blood pressure of patients, preventing occurrence and development of heart and cerebral vessel diseases, controlling kidney diseases occurrence of hypertension patients with with diabetes, improving heart functions of the patients, and reducing occurrence rate of myocardial infarction and other serious incidents.

The invention discloses an external traditional Chinese medicine preparation for treating diabetic complications as well as a preparation method and an application. The external traditional Chinese medicine preparation for treating diabetic complications is prepared from raw materials in parts by weight as follows: 5-25 parts of flos lonicerae, 4-16 parts of rhizoma coptidis, 7-17 parts of rehmannia roots, 2-15 parts of kudzuvine roots, 6-13 parts of bitter gourds, 5-14 parts of inonotus obliquus, 6-16 parts of flos carthami, 5-15 parts of honeysuckle stems and 50-120 parts of alcohol. The external traditional Chinese medicine preparation adopts a traditional Chinese medicine formula, has a good curative effect, takes effect rapidly, has no toxic or side effects, is used for treatment by external application and is favorable for body health of patients; the external traditional Chinese medicine preparation has the efficacy of clearing away heat and toxic materials, eliminating swelling, promoting granulation, dispersing blood stasis, eliminating carbuncle, relieving itching, performing sterilization and the like; the external traditional Chinese medicine preparation can effectivelytreat various complications caused by diabetes and particularly has better curative effects on diabetic foot diseases, nervous lesion, cardiac cerebrovascular disease, eye lesion and the like; besides, the external traditional Chinese medicine preparation has better efficacy for barbiers, bedsore and wound healing, and the added value of the medicine is increased.

The invention relates to a total-nutrient multifunctional compound natto and pine pollen health-care product, which is prepared by mixing 20 to 80 weight percent of natto, 20 to 80 weight percent of pollen, 1 to 15 weight percent of tea polyphenol and 2 to 20 weight percent of resveratrol, wherein the weight percentage ratio of medicaments to auxiliary materials is 20-80 weight percent: 80-20 weight percent. The health-care product can be formed into capsules, tablets, chewable tablet, grains, oral liquid and soft capsules. The product offers remarkable health-care effects through properties of treating cerebral and vascular diseases, endocrinopathy, digestive system diseases and nervous system diseases, preventing and curing cancers, improving immunity, resisting bacteria, diminishing inflammation, resisting oxidization, radiation, osteoporosis and aging, reducing weight, skin beautifying, and the like. The product has an active social and economic significance for disease prevention, body building and industrial promotion realization.

A bioactive wine for improving physiologic mechanism and immunity and preventing and relaxing diseases is prepared from basic grains wine, animal's organs (heart, brain, thymus, liver, spleen, etc), Chinese-medicinal materials, xylitol, lecithin, and honey through extracting active components and proportionally mixing.

Cerebrovascular treatment at an intracranial location beyond the petrous segment of the carotid artery can be challenging due to blood vessel size and tortuosity. First pass cerebrovascular thrombectomy success rate under only fluoroscopic guidance can be low (e.g., 25.1%) but an angioscope can help improve efficacy. A sheath catheter can be advanced toward the cerebrovascular pathology. Its distal balloon can be inflated. An angioscope can be inserted via its working lumen for viewing. The sheath catheter can have a stepped-down lateral profile and can extend the working channel a distance beyond the balloon. A dual concentric lumen structure can include an inner body and an outer body, defining an inflation lumen therebetween, with one or more portions of one or more layers stretched or cut or both, such as to provide bending flexibility. Reflow techniques can be used to help bond layers together.

A heart and brain nourishing traditional Chinese medicine smoking quitting health-care product is prepared from 3-10 g of flos carthami, 6-13 g of lotus leaf, 6-13 g of herba lophatheri, 6-13 g of root of red-rooted salvia, 3-10 g of chrysanthemum flower, 6-13 g of herba eupatorii, 6-13 g of rhizome chuanxiong, 6-13 g of root of common peony, 2-9 g of herba menthae and 0.2-0.9 g of honey. The flowers, stems and leaves of rare plants are adopted as raw materials, a subtle fragrance is generated after burning and can restore consciousness, promote qi and blood circulation, improve microcirculation, soften blood vessels, increase blood oxygen supply to heart and brain, help quit smoking and the like after being absorbed by the human body, and the product is a novel smoking quitting health-care product capable of preventing cardiac cerebrovascular diseases and overcoming nicotine addiction.

The invention discloses a traditional Chinese medicine composition for treating diabetes and its complications and a preparation method thereof. The composition is mainly composed of following medicinal materials: Bombyx Batryticatus, Rhizoma Sparganii, Radix Astragali, Fructus Corni, Radix Trichosanthis, Rhizoma Atractylodis, Rhizoma Curcumae and Fructus Tribuli. The composition is mainly used for treating diabetes and various complications, including diabetes macrovascular complications (coronary heart disease, hypertension and cerebrovascular disease), diabetic microangiopathy (diabetic nephropathy and diabetic ocular fundus pathology), diabetic peripheral neuropathy and the like and has significant clinical therapeutic effect without significant side effect; as the composition is substantially made with medicinal and edible drugs specified in Chinese pharmacopoeia, the composition also has the advantages of low price, good safety and the like.

The invention discloses a dietary therapy formula with antioxidant and bacteriostatic effects and capable of enhancing cardiovascular and cerebrovascular functions and human immune function The formula is composed of the following components of soybean glycopeptide, resistant dextrin, maltodextrin, inulin, fructo-oligosaccharide, flaxseed oil microcapsule powder, corn oligopeptide powder, a black fungus extract, a radix puerariae extract, a fructus crataegi extract, a tartary buckwheat extract, cranberry fruit powder, gamma-aminobutyric acid, D-ribose, L-arabinose, taurine, selenium-enriched yeast powder and multivitamins. According to a product with the compound formula, various soybean glycopeptides are used as main raw materials, and various natural pure traditional chinese medicine components are matched for auxiliary use so that the blood pressure and blood fat can be effectively reduced; meanwhile, through antioxidant and bacteriostatic effects, the human immunocompetence can be well improved, and the effects of effectively resisting aging and delaying aging time are achieved; and particularly, by improving the cardiovascular and cerebrovascular functions, the occurrence of diseases caused by cardiovascular and cerebrovascular diseases is inhibited or reduced; and the product is a universal compound beverage product suitable for general drinking of the public.

The present invention relates to a method for predicting the risk of having or developing Intracranial aneurysms (IA) in a subject, by identifying at least one mutation in an angiogenic protein, such as Angiopoietin-Like 6 (ANGPTL6). In particular, inventors identified one rare nonsense variant (c.1378A>T) in the last exon of the ANGPTL6 gene which encodes a 10 circulating pro-angiogenic factor mainly secreted from the liver shared by the 4 tested affected members of a large pedigree with multiple IA carriers. They GC showed a 50% reduction of ANGPTL6 serum concentration in heterozygous c.1378A>T carriers compared to non-carrier relatives, due to the non-secretion of the truncated protein produced by the c.1378A>T transcripts. They observed a higher rate of individuals with a history of high blood pressure 15 among affected versus healthy carriers of ANGPTL6 variants, suggesting that ANGPTL6 could trigger cerebrovascular lesions when combined with other risk factors such as hypertension.

The invention relates to a novel compound with excellent inhibition effect on aldose reductase. The effect of the novel compound is even better than that of conventional aldose reductase inhibitors. The novel compound possesses excellent prevention and treatment effects on diabetic syndromes such as diabetic cardiovascular and cerebrovascular diseases, diabetic nephropathy, diabetic neuropathy, and especially diabetic retinopathy.

The invention relates to a method for obtaining scutellarin from a thymus plant. The extractive is derived from labiatae thymus plant. Particularly, high-purity scutellarin is prepared by taking thymus quinquecostatus, thymus quinquecostatus var. przewalskii, thymus quinquecostatus var. asiaticus, thymus mongolicus or thymus altaicus as a raw material through processing steps such as solvent extraction, macroporous resin separation, and recrystallization. The scutellarin can treat cardiovascular and cerebrovascular diseases such as acute myocardial infarction, ischemic cerebrovascular disease, coronary heart disease, and angina pectoris. The preparation method has abundant raw material resources, simple technology, and low cost. The requirement of the medical market for scutellarin can be satisfied. Non-volatilizing parts of the thymus plant, such as thymus quinquecostatus, thymus quinquecostatus var. przewalskii, thymus quinquecostatus var. asiaticus, thymus mongolicus or thymus altaicus can be developed, so that many things can be achieved at one stroke, and the method has a bright industrial application prospect.

The invention discloses a case that caffeic acid can inhibit homocysteine induced leucocyte non-receptor tyrosine kinase Scr activation, and can further inhibit a PI3K / Akt signal pathway, the leucocyte adhesion molecule integrin beta2 expression, and the hyperhomocysteinemia induced rolling and adherence of leucocytes in leptomeningeal venules of mice, so the caffeic acid can control the hyperhomocysteinemia initiated cerebrovascular disease degeneration diseases.