41 results about "Brain vessel" patented technology

The present invention are co-crystals of Uric Acid with increased solubility with respect to crystals of Uric Acid, suitable for the pharmaceutical use. The invention comprises co-crystals with L-lysine, L-arginine, ethylene diamine, and tromethamine as co-formers, pharmaceutical compositions thereof and their therapeutical use in the prevention or treatment of cerebrovascular diseases.

The present invention belongs to the fields of medicine, health care and food, and specifically relates to use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The technical problem to be resolved by the present invention is to provide the use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The composition of the present invention includes the alcohol and the cooling agent. Further, the composition includes an organic acid. The alcohol in the composition is 1%vol-99%vol, and the cooling agent therein is 0.05ppm-500ppm. The composition provided according to the present invention can play the role of regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality in a short period.

This invention relates to inhibitors of nitrogen-containing heterocyclic derivatives, their preparation methods, and applications. In particular, this invention relates to compounds of general formula (I), their preparation methods, pharmaceutical compositions containing such compounds, and their use as inhibitors in the treatment of cardiovascular and cerebrovascular diseases, wherein the substituents in general formula (I) are the same as defined in the specification.

The application discloses a portable detection kit for assisting in predicting a cerebral vascular risk, a blood sample is processed through a sample processing module and input corresponding test paper, a detection result of the test paper is collected by a biological sensing module, and the detection result is calibrated and temporarily stored through an electronic control module, so that a user can acquire the calibrated detection result through a target device in an NFC touch mode and automatically send the calibrated detection result to a cerebral vascular disease monitoring digital platform, cerebral vascular risk prediction is performed by the cerebral vascular disease monitoring digital platform, and the portable detection kit has the beneficial effects of high portability, simple operation and high detection result accuracy.

This invention discloses a radioactive molecular probe for targeting CSPG4 / NG2, its preparation method, and its application. The radioactive molecular probe comprises the structure shown in Formula I or Formula II. The technical solution of this invention uses a radioactive molecular probe to specifically recognize CSPG4 / NG2 in vivo through the target polypeptide portion, thereby achieving specific nuclear medicine positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging diagnosis of CSPG4 / NG2 positive tumors or CSPG4 / NG2 positive lesions, such as autoimmune diseases and cardiovascular and cerebrovascular diseases, thereby realizing early diagnosis and efficacy evaluation of malignant tumors.

The application discloses a fusion protein CHC targeting soluble IL-17RD, a preparation method and application thereof. The fusion protein CHC is formed by connecting and fusing two sIL-17RD neutralizing nanobodies CQ5 and CQ13 with human serum albumin (HSA) through a linker, and the structure is CQ5-Linker-CHC-Linker-CQ13, and the amino acid sequence is shown as SEQ ID NO. 1. The application further provides a gene sequence coding the fusion protein and an adeno-associated virus AAV-PHP.eB carrier containing the gene. The neutralizing nanobody fusion protein can specifically bind and neutralize the biological function of sIL-17RD, regulate the brain vascular endothelial cell homeostasis by directly inhibiting the inflammatory response of brain vascular endothelial cells induced by TNF-alpha and indirectly inhibiting the activation of microglial cells. The application can be used for treating or preventing neurodegenerative diseases such as Alzheimer's disease, and has the effects of protecting vascular injury, improving learning and memory and cognitive impairment, reducing beta-amyloid plaque deposition, reducing neuron loss and glial cell activation and the like.

The present application relates to nitrogen-containing heterocyclic derivative inhibitors, their preparation methods and uses. In particular, the present application relates to compounds of general formula (I), their preparation methods and pharmaceutical compositions containing the compounds, and their uses as inhibitors in the treatment of cardiovascular and cerebrovascular diseases, wherein the substituents in general formula (I) are the same as defined in the specification.

The disclosed system provides an integrated neuroimaging analytics platform for comprehensive preoperative neurosurgical planning, intraoperative neurosurgical guidance and post-operative assessment by processing multimodal MRI (structural, diffusion, functional, and angiography) and CT data. The platform performs detailed anatomical characterization by delineating tumor subregions (peritumoral edema, enhancing tumor, and necrotic core), segmenting brain tissues (gray matter, white matter, and CSF), and executing lobe, cortical / subcortical parcellation. Advanced 3D rendering visualizes tumors alongside critical white matter fibre tracts derived from diffusion MRI, while MRA data is used to segment cerebrovascular structures, and functional MRI analysis identifies eloquent cortices associated with motor, speech, and visual functions. All results are integrated within a user-friendly GUI featuring advanced multiplanar slicing and a smart brush for interactive mask editing, complemented by a speech-to-text engine for streamlined analytical reporting. This comprehensive approach facilitates precise and efficient surgical planning, thereby enhancing patient safety and improving clinical outcomes.

Provide are an acid salt of a class of nitrogen-containing heterocyclic derivatives and a crystal form thereof, a preparation method therefor, and a use thereof. Specifically, provided are an acid salt of a compound represented by general formula (I) and a crystal form thereof, a preparation method therefor, and a pharmaceutical composition containing a therapeutically effective amount of the crystal form, as well as a use thereof as an inhibitor in the treatment of cardiovascular diseases, cerebrovascular diseases, and other diseases.

This invention relates to the field of neural network construction technology, and more particularly to a method and system for constructing a dynamic prediction model for cerebrovascular diseases based on artificial intelligence. The invention first constructs a graph network model with continuous time slices and defines multimodal feature nodes. Based on the evolutionary correlation of historical data, pruning and sparsity constraints are applied to the fully connected matrix between layers to construct a sparse topology model. Subsequently, fact evolution nodes are activated based on patient clinical data, and reverse path backtracking is performed with these nodes as endpoints. A masking mechanism is used to block non-predetermined fact branches, locking the unique historical path. Finally, this path is transformed into a context vector and injected into subsequent layers to achieve model state reconstruction and dynamic weight updates. This invention, through a global pruning-path locking-dynamic reconstruction mechanism, effectively filters clinical noise in disease progression, solves the path drift problem of traditional time-series prediction, and significantly improves the accuracy of individualized predictions in the mid-to-late stages while greatly reducing the number of parameters.

This invention relates to the crystal form of a macrocyclic derivative, its preparation method, and its application. In particular, this invention relates to the crystal form of compounds represented by general formulas, their preparation methods, and pharmaceutical compositions containing therapeutically effective amounts of the crystal form, and their use as inhibitors in the treatment of cardiovascular and cerebrovascular diseases.

The application provides a health / sports management system characterized in application to cerebrovascular disease supervision, comprising: a health management module for collecting and recording health information, comparing the health information with preset diagnostic criteria to obtain a comparison result, and outputting a corresponding prompt according to the comparison result; the health management module is also used for collecting relevant scale questionnaires and recording health conditions according to the relevant scale and questionnaires; the health management module is also used for receiving and managing admitted cerebrovascular disease diagnosis and treatment results; a sports management module is used for scoring and evaluating facial paralysis, upper limb and lower limb movement according to a to-be-evaluated sports video, and obtaining a detection result according to the scoring and evaluation. The system can realize the combination of recording and feedback, meet the universality from health recording to secondary prevention and the compatibility from health follow-up to functional evaluation, realize user self-testing of sports functions, and facilitate user health self-checking.

A phthalazine ketone compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, and a medical use of the compound. The compound of the present application has a neuroprotective effect and can be used for treating / preventing cerebrovascular-related diseases.

The application relates to the technical field of cerebral vascular disease prediction, in particular to a large arteriosclerotic cerebral stroke risk prediction method and system. The application can effectively evaluate the risk of cerebral vascular disease, especially cerebral stroke, by combining multiple indexes and image group characteristic data, can obtain score data reflecting the risk development state of the current cerebral stroke, and can more intuitively determine the wind direction degree through the score data, so that the overall automatic prediction of cerebral stroke is realized.

The utility model discloses a tunable constant current interventional electric coagulation equipment, including display screen, current regulation button, tunable constant current electric coagulation equipment, interventional medical guide wire interface and medical guide wire, can coordinate constant current electric coagulation equipment including battery, power module, high frequency arbitrary waveform generating module, constant current output module, high frequency arbitrary waveform generating module includes digital control module and frequency synthesis module, and constant current output module includes current sampling circuit, constant current module. The utility model through microcontroller flexible configuration output waveform's amplitude and frequency, tunable output 1~37.5MHz's high frequency alternating current, realize 0~3mA's weak alternating current constant current output, satisfy 100's step range of muA, expand the electric coagulation equipment output constant current alternating current's ability, improved the step precision of output weak current, avoided the nerve reflex reaction that traditional electric coagulation treatment scheme in direct current signal to brain hemangioma class disease carries out electric coagulation treatment when causes.

The present application relates to nitrogen-containing heterocyclic derivative inhibitors, their preparation methods and uses. In particular, the present application relates to compounds of general formula (I), their preparation methods and pharmaceutical compositions containing the compounds, and their uses as inhibitors in the treatment of cardiovascular and cerebrovascular diseases, wherein the substituents in general formula (I) are the same as defined in the specification.

This invention relates to a class of nitrogen-containing heterocyclic derivative inhibitors, their preparation methods, and applications. In particular, this invention relates to compounds represented by general formula (I), their preparation methods, pharmaceutical compositions containing such compounds, and their use as inhibitors in the treatment of cardiovascular and cerebrovascular diseases, wherein the substituents in general formula (I) are the same as defined in the specification.

This invention belongs to the field of organ-on-a-chip technology, providing a blood-brain barrier / neuronal co-culture chip, an organ-on-a-chip, its construction method, and applications. The blood-brain barrier / neuronal co-culture chip provided by this invention includes a reservoir, vascular endothelial channels, a hydrogel chamber, and a brain region microenvironment channel. The vascular endothelial channels are used for seeding brain microvascular endothelial cells; the hydrogel chamber is used for seeding brain perivascular cells and astrocytes, and exchanges substances with the vascular endothelial channels through a porous membrane; the brain region microenvironment channel is used for seeding neurons, constructing a three-dimensional neuronal network growth environment. Using this blood-brain barrier / neuronal co-culture chip as the chip body, the construction of the blood-brain barrier, the glial support microenvironment, and the three-dimensional developmental space of neurons can be realized, achieving dynamic interaction between the blood-brain barrier and the neuronal microenvironment. It has broad application prospects in the study of the mechanisms of nervous system diseases and the evaluation of nervous system drugs.

The application provides a construction method of a zebrafish model of diabetic cerebral hemorrhage sequelae for high-throughput drug screening, and belongs to the technical field of biotechnology.The first zebrafish model capable of comprehensively simulating the complex pathological phenotypes of clinical diabetic cerebral hemorrhage sequelae is successfully constructed, and the blank of the research model in the field is filled.The pathological changes of the model are highly consistent with the symptoms of the patients with clinical diabetic cerebral hemorrhage sequelae, such as glucose metabolism disorder, pancreatic beta cell damage, cerebral vascular injury and hemorrhage, brain cell apoptosis, inflammatory reaction and behavior abnormality, and the limitation that the existing single disease model cannot simulate the synergistic pathogenesis of diabetes and cerebral hemorrhage is overcome, so that a reliable experimental animal model is provided for high-throughput screening of active ingredients against the disease.

This invention provides a method, device, and computer storage medium for obtaining cerebrovascular function compensation indicators. The method includes: acquiring four-dimensional image data of a subject's brain, including dynamic magnetic susceptibility contrast-enhanced MRI data or CT perfusion imaging data; inputting the four-dimensional image data into a physical information neural network model, which outputs cerebrovascular function compensation indicators, including cerebrovascular reactivity as a first indicator and oxygen extraction fraction as a second indicator; wherein the physical information neural network model includes a compensation mapping component, which generates the first and second indicators and introduces a nonlinear inverse proportional relationship to correct the first and second indicators. This invention provides a safe, efficient, accurate, and comprehensive method for obtaining cerebrovascular function compensation indicators.

This application provides a knowledge graph-based rehabilitation diagnosis and treatment system and method for cerebrovascular diseases. It maps multimodal rehabilitation data onto a pre-defined knowledge graph, generating a feature subgraph. Starting with the core functional impairment node in the patient's feature subgraph, a multi-hop relationship expansion search is performed in the knowledge graph to obtain a set of candidate rehabilitation intervention nodes. Based on the empirical validity data of each candidate rehabilitation intervention node in a historical patient group with similar characteristics to the current patient, the topological association strength of the knowledge graph, and the feasibility constraints of the target patient's current medical scenario, the personalized fit of each candidate rehabilitation intervention node is determined. The results of ranking each candidate rehabilitation intervention node according to all personalized fits form a draft recommendation of a structured rehabilitation plan for the target patient. Using the scheme of this application, multimodal rehabilitation data and dynamic medical knowledge of patients can be integrated to conduct intelligent rehabilitation plan recommendations.

The application provides a cerebral vascular disease risk assessment method and device based on a large model intelligent agent, the method comprising: acquiring multi-source information of a user, the multi-source information of the user representing a comprehensive health status of the user; according to the multi-source user information, combining a cerebral vascular disease knowledge base, acquiring corresponding medical guideline knowledge fragments as context reference materials; inputting the multi-source user information and the context reference materials into a health status assessment model to obtain a health status assessment result output by the health status assessment model, the health status assessment result comprising a cerebral vascular disease risk assessment result and health guidance suggestions; through the multi-source user information and the introduction of the cerebral vascular disease knowledge base, the model can simultaneously consider multiple factors such as physiological indicators, medical history backgrounds and lifestyles of the user, and combined with the implied medical logic, the evaluation process is ensured to have a basis, the professional degree and the reliability of the evaluation result are significantly improved, and the personalized generation of the suggestion content is realized.

This invention discloses a traditional Chinese medicine composition for treating cerebrovascular diseases, belonging to the technical field of cerebrovascular disease drugs. The composition comprises the following components in parts by weight: 10-30 parts of Polygonatum sibiricum, 6-15 parts of Rosa laevigata, 6-12 parts of Euonymus alatus, 6-15 parts of Polygonum cuspidatum, 3-9 parts of Acorus tatarinowii, 3-10 parts of Alpinia oxyphylla, 3-6 parts of Aralia elata septum, 3-10 parts of Rhodiola rosea, 3-10 parts of Bletilla striata, and 1-6 parts of Cinnamomum cassia. This invention addresses the pathological characteristics of cerebrovascular diseases, including long disease courses, multiple risk factors, and involvement of multiple target organs. Through the systematic combination of ten herbs, it can simultaneously achieve cerebrovascular protection, nerve function repair, and protection against multi-organ damage. Animal experiments and clinical observations have confirmed that this composition can significantly improve patients' neurological deficit scores, reduce the incidence of complications, and has clear preventive and therapeutic effects on secondary complications such as stress ulcers and renal impairment, while also possessing antithrombotic and hemostatic properties and high safety.

The application discloses a cerebrovascular disease secondary prevention intelligent management system, relates to the medical and health information technology field, and comprises a doctor end and a patient end, both of which are connected through network communication; the patient end is integrated with an Internet of Things device to realize automatic / manual uploading of health data; the doctor end calls a cerebrovascular disease vector knowledge base constructed based on an open source large language model based on medical records, discharge summaries and real-time monitoring data when patients are grouped, generates a personalized management scheme for each patient through a prompt word engineering and retrieval enhancement generation mechanism, and the content covers blood pressure, blood glucose, blood lipid, medication and exercise management; the system forms a closed-loop intervention through a health liaison officer distribution mechanism, message reminders, health clock-in and weekly feedback; the system also supports clinical endpoint event and adverse event reporting, sub-center management and role permission control. The application can effectively improve the compliance of cerebrovascular disease patients in secondary prevention and the standard rate of risk factor control, and reduce the risk of recurrence.

This invention discloses a class of quinolinone derivatives and their pharmaceutically acceptable salts. The quinolinone derivatives of this invention are compounds with phosphodiesterase 3A (PDE3A) inhibitory activity, possessing significant potential therapeutic value for use in the treatment of tumors, cardiovascular diseases, cerebrovascular diseases, or dementia.

Based on combination therapy, we propose a cell therapy that can significantly enhance the therapeutic effect of treatment for cerebrovascular disease, ischemic heart disease, or traumatic cerebrospinal nerve injury in subjects compared to conventional methods. [Solution] A cell preparation containing microglia and / or monocytes, which have the ability to promote angiogenesis and axon extension, is administered to the subject. By repeatedly implementing a bidirectional biofeedback loop between the nervous system and the musculoskeletal system, the effect of improving the motor function of the subject's brain, nervous system, and muscular system is enhanced.

This application discloses a method and system for predicting perioperative cardiovascular and cerebrovascular adverse events, belonging to the field of medical data processing technology. First, an initial parameter set is extracted from the actual physiological parameter set based on a moving time window. Then, the initial parameter set is cleaned, and a confidence parameter set and a target parameter set are calculated. Subsequently, a risk relationship comparison table and a basic pathological feature set are obtained. A first correction coefficient set is calculated based on the confidence parameter set. Then, an early warning model is generated based on the first correction coefficient set and the target parameter set. Next, a co-variance analysis is performed on the early warning model and the target parameter set to calculate a second correction coefficient. Finally, an early warning result is generated based on the second correction coefficient and the early warning model. This application constructs a personalized prediction model based on the measured parameters of the subject, eliminating the influence of individual differences. Simultaneously, medical rule constraints and data credibility constraints are introduced into the prediction process through the risk relationship comparison table and confidence parameters, improving the accuracy of the prediction.

The application discloses an AI-based cerebrovascular disease risk dynamic prediction method and system, relates to the technical field of intelligent medical data processing, and comprises the following steps: based on an annotated event stream, taking a corresponding time point as a time window boundary when an event trigger condition is met, dynamically adjusting a time window span with an irregular sampling density, generating a dynamic time window set, and mapping the dynamic time window set into a time window sample package; inputting the time window sample package into a risk prediction model based on a time interval attenuation gate cycle, obtaining an original risk probability value, and synchronously acquiring drift evidence deviating from a previous state of an individual; performing online recalibration on the original risk probability value according to the drift evidence, updating an individualized baseline calibration factor, forming a calibrated risk probability value, and simultaneously performing effectiveness verification to obtain a final effective risk probability value. The application realizes stable and dynamic prediction of cerebrovascular disease risk.

This invention discloses a pharmaceutical composition comprising a compound of formula I and dextroborneol, which has shown unexpected effects in treating cerebrovascular diseases and central nervous system diseases.