The present invention discloses compound fructus cannabis capsules and a preparation method thereof, wherein the compound fructus cannabis capsules are mainly prepared from the following raw materials by weight: 500-1000 parts of fructus cannabis, 500-1000 parts of marine microalgae, 500-1000 parts of ganoderma lucidum, 250-500 parts of camellia nitidissima leaf, 100-200 parts of camellia nitidissima flower, 25-50 parts of camellia nitidissima seeds, 500-1000 parts of black grape, 50-100 parts of walnut meat, 50-100 parts of Chinese Wolfberry, and 500-1000 parts of red date. According to the present invention, the compound fructus cannabis capsules have characteristics of fine formula selection and essence concentration, have effects of significant memory improvement and the like, are main used for preventing and treating hypomnesis, dysmnesia and Alzheimer disease, can further be used for preventing and treating Parkinson's disease, cardiovascular and cerebrovascular diseases, and malignant tumors caused by cerebrovascular diseases, anti-aging, and the like, and can further be used for memory enhancing, learning ability enhancing, intelligence enhancing and body constitution enhancing of teenagers or healthy people.