19 results about "Brain protection" patented technology

The present application provides a propofol analogue, a preparation method thereof and application thereof in non-narcotic field. The propofol analogue has a structure as shown in general formula (G). The propofol analogue of the present application can greatly reduce or eliminate the affinity to GABA receptor, i.e. weaken or eliminate the narcotic property. It targets specific targets and shows effects in improving sleep, regulating blood pressure, relieving vomiting, resisting depression, protecting heart and brain, etc. (G).

The invention belongs to the technical field of medicine, and discloses a thoracic aorta in-situ fenestration and whole-course brain protection integrated device and method. According to the method, a bundling balloon is formed by a plurality of small balloons, the different small balloons are controlled to be inflated or shrunk under pressure relief, and the angle of a puncture needle is adjusted through the bundling balloon catheter. And the far-end protection umbrella covers the cluster balloon catheter and is used for preventing thrombus from escaping to the far end. According to the invention, the bundling balloon composed of a plurality of small balloons is designed, and the angle of the puncture needle is adjusted by controlling the different small balloons to expand by filling or shrink by releasing pressure, so that the time for an instrument to enter a membrane rupture window is greatly shortened, and the positioning accuracy of a membrane rupture point of the covered stent is improved; meanwhile, a far-end protective umbrella is arranged to prevent thrombus and other foreign matters from escaping to the far end.

The application provides a distal filter brain protection device for use in cardiac surgery, comprising a sleeve with an inlet end and an outlet end; the sleeve is divided into 2-3 sleeve branches at the inlet end; the sleeve contains 2-3 implant sheaths; one implant sheath is introduced from each sleeve branch; the implant sheaths are all led out at the outlet end; the implant sheaths are provided with guide wires, and the front ends of the guide wires are provided with umbrella-shaped filter screen devices; the umbrella-shaped filter screen devices are provided with multiple ultrasonic emission balls containing corner reflectors to enhance the ultrasonic reflection effect of the devices. The distal filter brain protection device of the application can simultaneously provide precise filter implantation and removal for multiple blood vessels, especially two carotid arteries, in cardiac surgery, and the implantation and detailed operation process can be completed under ultrasonic monitoring.

The application discloses a database high-availability cluster brain split protection method and device and medium, belongs to the technical field of database high-availability cluster, and is used for solving the technical problems that the existing PostgreSQL high-availability cluster scheme is prone to cluster brain split, mis-switching and data inconsistency problems in network partition and communication anomaly due to the lack of network topology awareness, communication quality quantification, state cross-verification and hierarchical isolation strategy. The method comprises the following steps: after triggering the master selection process of the current cluster, detecting the communicable nodes in the current cluster; performing multi-dimensional quality perception on the communicable nodes to obtain corresponding node state parameters; performing weighted calculation according to the node state parameters to obtain a weighted value; if the weighted value reaches a first preset threshold, performing visibility consensus verification on each communicable node; after the visibility consensus verification is passed, determining a candidate master selection area based on the regional awareness master selection strategy; and selecting a new master node in the candidate master selection area according to the hierarchical response strategy.

The utility model discloses a brain protection pillow and a cart with the brain protection pillow, the brain protection pillow comprises at least one deformable maintaining part and a pillow part, and the pillow part comprises a bearing unit, two protection units and a containing groove. The two protection units are adjustably arranged on the two opposite sides of the bearing unit respectively, so that the containing groove is formed between the bearing unit and the two protection units and used for containing the head of an infant, and the maintaining part extends from one protection unit to the other protection unit through the bearing unit and is used for maintaining the head of the infant. When force is applied to the protection unit to enable the angle of the protection unit relative to the bearing unit to be adjusted, the maintaining part is stressed and deformed, after external force applied to the protection unit is removed, the maintaining part maintains the angle of the protection unit relative to the bearing unit, and therefore the angle of the protection unit relative to the bearing unit is adjusted. The width size of the containing groove can be adjusted according to needs.

The invention relates to the technical field of medical first-aid equipment, in particular to a device for heatstroke first aid and mild hypothermia treatment. Comprising a foldable cabin body; the composite cooling unit comprises a contact type conduction cooling module, a targeted brain cooling module and an environment convection cooling module; the contact type conduction cooling module is an ice blanket; the targeted brain cooling module is an ice cap, and the environment convection cooling module comprises a cold air inlet formed in the top end of the cabin body, an air outlet formed in the bottom of the cabin body and refrigeration equipment connected with the cold air inlet; and the intelligent monitoring and control unit is connected with the ice blanket, the ice cap and the refrigeration equipment and used for adjusting the temperature of the ice blanket and the ice cap and the cold air output power of the refrigeration equipment. The device provided by the invention integrates cooling, monitoring and brain protection functions, is efficient and cooperative in cooling and accurate in temperature control, can have a brain protection effect, improves the treatment safety, is light and portable, and is suitable for complex environments without fixed medical facilities, such as fields and battlefields.

The present application relates to a vincamine derivative, a preparation method therefor, and use thereof, and belongs to the technical field of preparation of vincamine derivatives. The vincamine derivative has the following advantages: (i) Modification of the tail chain increases the lipid solubility of vincamine compounds without affecting the cerebral blood flow regulation of vincamine itself, thereby helping the carried drug penetrate the blood-brain barrier, exert a brain-protective effect, and improve cerebral microcirculatory disorders. (ii) The tertiary amine group in the parent nucleus structure of the vincamine derivative is ionizable under acidic conditions, which enables efficient delivery and lysosomal escape of nucleic acid drugs through charge adsorption, thereby improving intracellular transport. (iii) The vincamine derivative inherits various pharmacological activities inherent to vincamine, and has high safety. Therefore, the vincamine derivative has good application prospects in brain-targeted delivery of drugs for treating brain diseases.

This invention provides a composite composition containing nervonic acid and its use in brain nerve repair, belonging to the field of biotechnology. The invention uses nervonic acid and phosphatidylserine, combined with plant extracts fermented by a microbial concoction of *Lactobacillus acidophilus*: *Lactobacillus rhamnosus*: *Bacillus belyssae* = (2-3):1:1, to form a composite composition. This scientific formulation achieves synergistic effects from multiple components, improving neurological deficits, reducing cerebral infarction volume, decreasing the release of neurotrophic markers, and upregulating neurotrophic factor expression through multi-target synergistic effects. Furthermore, this synergistic effect depends on specific component ratios, providing crucial experimental support for the development of subsequent brain-protective functional compositions. This composition can be widely applied to the preparation of brain nerve repair drugs, functional foods, and dietary supplements, possessing promising industrialization prospects and clinical value.

The invention discloses an edible and medicinal composition with effects of lowering lipid and protecting heart and brain as well as a preparation method and application of the edible and medicinal composition, and belongs to the technical field of functional foods. The food and medicine homologous composition is prepared from three food and medicine homologous raw materials including broccoli seeds, lucid ganoderma and radix puerariae. Broccoli seeds are heated, dried and smashed, and broccoli seed powder is obtained; the preparation method comprises the following steps: uniformly mixing crushed lucid ganoderma, radix puerariae and broccoli seed powder according to a ratio, heating and extracting, concentrating the obtained filtrate, and carrying out spray drying to obtain a core composition; and adding the auxiliary active composition into the core composition, and uniformly mixing to obtain the edible and medicinal composition with the effects of lowering lipid and protecting heart and brain. The food and medicine homologous composition can be prepared into a multi-layer tablet with a core / shell structure, and the multi-layer tablet can be eaten as a functional food or health-care food with the functions of reducing blood fat, resisting oxidation or protecting heart and cerebral vessels. Animal experiments and crowd feeding trials show that the composition has the effect of regulating the overall metabolism of the body, can reduce the blood fat level and regulate intestinal flora, and has a good auxiliary relieving effect on symptoms of cardiovascular and cerebrovascular related diseases.

The application relates to the technical field of sports protective equipment, and discloses a buffering electronic head protector for taekwondo, which comprises a head protector main body, a buffering protection assembly and a sensing system, the head protector main body comprises a head protection part and a back brain protection part, an adjusting gap is formed in the bottom of the back brain protection part, adjusting belts are connected to the two sides of the adjusting gap, a drag tongue is arranged in the middle of the adjusting gap, the drag tongue is perpendicular to the length direction of the adjusting belt, the end of the drag tongue is integrally formed with the head protector main body, and the drag tongue is located on the side of the adjusting belt which faces the inside of the head protector main body. The application has the effect of improving the comfort of the wearer.

The application discloses an integrated closed-loop brain protection device, and relates to the field of nerve interventional medical instruments. A balloon catheter comprises a balloon and a catheter body. A main cavity and multiple auxiliary cavities are arranged in the catheter body. The main cavity penetrates through the catheter body, and the balloon is arranged at the top end of the catheter body. A multi-interface Y valve comprises a main channel and multiple auxiliary channels. The main channel comprises a first channel and a second channel. One end of the first channel and one end of the second channel are in communication with each other. The end of the first channel is connected with the tail end of the catheter body. The auxiliary channels are installed on the side wall of the main channel and are in communication with each other. A filtering unit comprises a filter screen. One end of the filtering unit is connected with the auxiliary channels. A negative pressure auxiliary unit is connected with the other end of the filtering unit through a backflow pipe. The negative pressure auxiliary unit guides the flow direction of blood through negative pressure. The application aims to provide an integrated closed-loop brain protection device. Through the multi-cavity balloon guide catheter body and the multi-interface Y valve, the problems of microembolus escape causing ipsilateral stroke, multi-stage filtration and autologous blood transfusion are solved.

The invention discloses an ice cap and a brain protection device, and relates to the technical field of medical instruments. The ice cap is used for the extracorporeal circulation operation and comprises an inner cap body and an outer cap body, the outer cap body is arranged on the inner cap body, a fluid filling cavity used for being filled with a cooling medium is defined by the outer cap body and the inner cap body, and the fluid filling cavity is suitable for being communicated with an external cooling machine. According to the ice cap, the fluid filling cavity is formed in the ice cap to contain the cooling medium, compared with a conventional manual ice water adding scheme, medical workers do not need to replace ice water when the ice cap is used, the using convenience of the ice cap is greatly improved, the cooling effect is improved, and therefore the brain protection effect is improved. In addition, the ice cap convenient to disassemble is provided, by arranging a zipper or a hook-and-loop fastener and the like, medical staff can conveniently open the ice cap and adjust the position of a monitoring device of the brain, operation is more convenient and faster, the monitoring device can be located at a proper examination position, and the medical monitoring accuracy is improved.

The invention provides a PEEP titration system and method based on multi-modal data, and belongs to the technical field of medical and industrial combination. According to the system, electroencephalogram signals, cerebral blood flow speed signals, arterial pressure signals and breathing machine PEEP level data in the mechanical ventilation process of a critical patient are synchronously collected, and after preprocessing and spectral analysis, the delta wave power proportion is calculated and serves as a sensitive index of cerebral hypoxia and ischemia; and aligning the multi-modal data according to timestamps and constructing a database. And based on a linear mixed effect model, performing statistical analysis by taking the DPR as a dependent variable and the PEEP level as an independent variable, and fitting a U-shaped curve to determine an optimal PEEP value. According to the PEEP titration system and method based on the multi-modal data, the blank that the influence of PEEP on a central nervous system cannot be objectively quantified in the prior art is filled up, cerebral ischemia and hypoxia injury is prevented from being aggravated by too high PEEP, and the respiration-brain protection collaborative management level of a neurological critical patient is remarkably improved.

The application discloses a tracheal catheter device with rotating permanent magnet positioning and selective brain cooling function and a temperature control method thereof, wherein a plurality of flexible semiconductor refrigerating sheets and a plurality of temperature and humidity sensors are inlaid on the inner wall side along the extension direction of the catheter and the side close to the outer wall of the flexible tracheal catheter; the function of heating the humidified gas entering the tracheal catheter is realized; the local low-temperature environment is realized by cooling the outer wall of the tracheal intubation tube, so that the brain is protected to a certain extent. The low temperature reduces the metabolic rate of brain cells and reduces the oxygen consumption of the brain, which helps to reduce brain injury and improve the brain function recovery effect of the patient; the flexible semiconductor refrigerating sheet and the temperature and humidity sensor are used for accurate temperature control, the temperature of the outer wall of the tracheal intubation tube is accurately adjusted, and the adverse effect of excessive temperature fluctuation on the brain protection effect is avoided, so that the method is more targeted and controllable than the traditional cooling method.

This invention provides a brain polypeptide raw material with brain-boosting and intelligence-enhancing properties and its preparation method. The preparation method includes the following steps: S1, pretreatment; S2, first hydrolysis: adjusting the pH of the pre-hydrolysate to 6.5-7.5, adding neutral protease at 3.5-4.5% of bovine brain protein mass, hydrolyzing at 50-60℃ for 1-3 hours, and obtaining the first hydrolysate after enzyme inactivation; S3, second hydrolysis: adjusting the pH of the first hydrolysate to 6.0-7.0, adding papain at 1.0-3.0% of bovine brain protein mass, hydrolyzing at 45-65℃ for 1.5-2.5 hours, and obtaining the second hydrolysate after enzyme inactivation; S4, post-treatment, to obtain the brain polypeptide raw material powder. This brain polypeptide raw material can significantly scavenge DPPH and ABTS free radicals, inhibit acetylcholinesterase activity, repair PC12 nerve cells, inhibit the expression of the pro-apoptotic gene Bax and promote the expression of the anti-apoptotic gene Bcl-2, thus exerting a brain-boosting and intelligence-enhancing effect and protecting brain nerves.

The invention belongs to the technical field of cardio-pulmonary resuscitation, and discloses a system and a method for optimizing a cerebral protection mechanism of hypoxic ischemia encephalopathy after cardio-pulmonary resuscitation, which are characterized in that an intracranial pressure monitoring device is used for monitoring the change of intracranial pressure in real time and evaluating the degree of brain injury and the condition of encephaledema; through intracranial pressure monitoring, a treatment scheme can be adjusted in time, and serious complications of cerebral hernia are prevented; meanwhile, the concentration change of oxyhemoglobin and deoxidized hemoglobin in the brain tissue is monitored through the brain oxygen saturation monitor by utilizing a near infrared spectrum technology, and the oxygenation state of the brain tissue is accurately reflected. Brain oxygen saturation monitoring is beneficial for guiding oxygen therapy and ventilation therapy and optimizing oxygen supply and oxygen consumption balance of brain tissue. The optimization system for the cerebral protection mechanism of the ischemic-hypoxic encephalopathy after the cardio-pulmonary resuscitation operation can remarkably reduce the degree of brain injury, promote neural function recovery and reduce the case fatality rate and disability rate of a patient.

The present application relates to a long-changma class derivative and its preparation method and application, belong to long-changma class derivative preparation technical field. The long-changma class derivative disclosed by the present application has the following advantages: (i) the modification of the tail chain increases the fat solubility of the long-changma class compound, and does not affect the brain blood flow regulation of the long-changma class itself, helps to carry the drug to penetrate the blood-brain barrier, and plays a brain protection role, improves the brain microcirculation disorder; (ii) the tertiary amine group in the parent nucleus structure of the long-changma class derivative has the property of ionization under acidic conditions, can achieve efficient carrying and lysosome escape of nucleic acid drugs through charge adsorption, and improve intracellular transport; (iii) the long-changma class derivative inherits the inherent various pharmacological activities of long-changma, and has high safety. Therefore, the long-changma class derivative disclosed by the present application has good application prospect in brain-targeted delivery of drugs for treating brain diseases.

1. Name of this design: Handle of an anti-thrombotic brain protection device. 2. Application of this design: The anti-embolism brain protection device is used in the medical field to prevent the formation of cerebral embolism, and the handle is used to perform the operation of delivering, adjusting, releasing, and retrieving the anti-embolism brain protection device. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.