50 results about "Brain protection" patented technology

The utility model relates to the technical field of headbands, in particular to a brain protection headband, which is used for surrounding and fixing along the head and comprises a headband body, an application band and an outer band, the application band and the outer band are fixedly connected, and the band surface of the application band is provided with a convex ball used for being applied to the head; the rubber inner pad is used for providing shaping support and is arranged in the headband body, and a third embedding cavity is formed in the rubber inner pad; the sweat-absorbing clamping pad is mounted at the third embedding cavity; according to the brain protection headband, a strip-shaped structure is adopted to replace an existing annular headband, so that the binding force of the headband is convenient to adjust; the shaping capability of the head band can be improved through the rubber inner pad arranged in the head band; in order to improve the wearing comfort, the sweat-absorbing clamping pad is arranged for absorbing sweat; in addition, a convex ball used for being applied to the head is arranged on the belt face of the application belt and can be matched with a strip-shaped structure to adjust the brain pressing force, the adjustability is high, and the application range is wider.

The utility model belongs to the technical field of medical instruments, and particularly relates to a novel brain protection device which comprises a catheter, a balloon conducting tube and a filter screen traction wire are arranged in the catheter, the filter screen traction wire slides in the catheter, one end of the filter screen traction wire is fixedly connected with a filter screen, the filter screen is embedded in the catheter, and the other end of the filter screen traction wire is fixedly connected with the balloon conducting tube. The filter screen is arranged on the balloon conducting tube in a sleeving manner, and the filter screen moves on the balloon conducting tube; through traction of the arranged filter screen traction wire, the filter screen moves to the outside of the catheter and opens in a blood vessel, falling calcified vascular tissue fragments are comprehensively intercepted and filtered, the filter screen traction wire is pulled outwards, the filter screen can be collected into the catheter, the filtered calcified vascular tissue fragments are wrapped, and the calcified vascular tissue fragments are taken out along with the brain protection device. And valve calcification fragments are prevented from blocking brain blood vessels.

The present invention provides the use of a traditional Chinese medicine composition prepared from polygonum multiflorum, aloe, cassia seed, wolfberry fruit, donkey-hide gelatin, ginseng, atractylodes macrocephala and fructus aurantii immaturus as main components in the preparation of a drug for preventing or treating ischemic stroke. The research results show that Shouhui Laxative Capsule can reduce the neurological deficit score of cerebral ischemia-reperfusion injury, decrease the area of cerebral infarction, relieve cerebral pathological injury, and reduce the inflammatory level in serum, and has a significant brain protection effect on cerebral ischemia-reperfusion injury. The traditional Chinese medicine composition of the present invention has definite curative effect and safe components, and has broad application prospects and positive clinical significance.

Disclosed are a hydroxypentyl benzoic acid diester compound, a method preparing the same, and an application of the same. This application uses a combination principle, on the one hand, the medicine concentration of butylphthalide in cerebral vessels is improved through a function of promoting the medicine to penetrate through a blood-brain barrier of dexborneol, and a multi-target multi-channel synergistic brain protection effect of the medicine is exerted; on the other hand, the treatment effect of dexborneol on cerebral ischemia is exerted. Anti-cerebral ischemia in-vivo pharmacodynamic activity evaluation is carried out on the synthesized compound, a high-activity candidate medicine is obtained, and industrial production can be achieved through the synthesis method.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for nasal feeding awakening in the severe illness department and a preparation method thereof. The traditional Chinese medicine composition is prepared from rhizoma acori graminei, storax, herba artemisiae scopariae, fructus trichosanthis, radix curcumae, radix salviae miltiorrhizae, herba cepbalanoplosis segeti, fructus citri, fructus amomi rotundus, radix polygalae, radix astragali seu hedysari, radix ginseng and radix glycyrrhizae. Through scientific formula compatibility and process optimization, the traditional Chinese medicine composition shows remarkable advantages in the aspects of awakening efficiency, neurological function repair, brain protection, clinical adaptability and the like, and a more effective treatment scheme is provided for awakening of the critical illness department.

The present application relates to the technical field of medical devices, in particular to a brain protection filter assembly, comprising a first frame body and a second frame body connected with the first frame body, the second frame body is provided with a first connecting body for connecting and positioning when the brain protection filter assembly is recovered, the present application has the beneficial effects that the first frame body and the second frame body can simultaneously cover the brachiocephalic trunk artery, the left common carotid artery and the left subclavian artery, ensuring the comprehensiveness of the protection range, in addition, the first connecting body provided on the second frame body can realize the free recovery of the brain protection filter assembly after long-time storage in the patient's body after operation, prolong the foreign body capture time, and improve the efficiency of preventing stroke.

The present application provides a propofol analogue, a preparation method thereof and application thereof in non-narcotic field. The propofol analogue has a structure as shown in general formula (G). The propofol analogue of the present application can greatly reduce or eliminate the affinity to GABA receptor, i.e. weaken or eliminate the narcotic property. It targets specific targets and shows effects in improving sleep, regulating blood pressure, relieving vomiting, resisting depression, protecting heart and brain, etc. (G).

The invention belongs to the technical field of medicine, and discloses a thoracic aorta in-situ fenestration and whole-course brain protection integrated device and method. According to the method, a bundling balloon is formed by a plurality of small balloons, the different small balloons are controlled to be inflated or shrunk under pressure relief, and the angle of a puncture needle is adjusted through the bundling balloon catheter. And the far-end protection umbrella covers the cluster balloon catheter and is used for preventing thrombus from escaping to the far end. According to the invention, the bundling balloon composed of a plurality of small balloons is designed, and the angle of the puncture needle is adjusted by controlling the different small balloons to expand by filling or shrink by releasing pressure, so that the time for an instrument to enter a membrane rupture window is greatly shortened, and the positioning accuracy of a membrane rupture point of the covered stent is improved; meanwhile, a far-end protective umbrella is arranged to prevent thrombus and other foreign matters from escaping to the far end.

The invention relates to a pharmaceutical composition for intraoperative brain protection in shoulder arthroscopy surgery. The pharmaceutical composition comprises midazolam, propofol, sufentanil, succinylcholine and atracurium besylate. According to the invention, rScO2 can be improved, the risk of cerebrovascular events can be reduced, but no obvious influence is generated on the circulation stability in the operation of a patient, the postoperative cognitive impairment and the like.

The invention discloses a tracheal catheter device with rotary permanent magnet positioning and selective brain cooling functions and a temperature control method of the tracheal catheter device. A plurality of flexible semiconductor chilling plates and a plurality of temperature and humidity sensors are embedded in the inner wall side and the portion, close to the outer wall side, of a flexible tracheal catheter in the catheter extending direction; the function of heating wet gas entering the tracheal catheter is achieved; the outer wall of the trachea cannula is cooled, a local low-temperature environment is achieved, and therefore a certain protection effect on the brain is achieved. The low temperature reduces the metabolic rate of brain cells, reduces oxygen consumption of the brain, contributes to relieving brain injury and improves the brain function recovery effect of a patient; the flexible semiconductor chilling plate and the temperature and humidity sensor are used for accurate temperature control, accurate adjustment of the temperature of the outer wall of the trachea cannula is achieved, adverse effects on the brain protection effect caused by too large temperature fluctuation are avoided, and the method is more targeted and controllable compared with a traditional cooling method.

According to the brain protection device based on clinical treatment, multi-direction examination and treatment of the brain can be achieved in multiple scenes based on clinical treatment, the angle coordinates of the device and the axial coordinates of examination and treatment tools can be flexibly adjusted in a customized mode, and the device is convenient to install, easy to operate and capable of moving in a parameterized mode.

The invention relates to compositions comprising urolithins with active agents, particularly compositions comprising urolithins and agents which promote brain health and / or immune health. The invention also relates to such compositions, for use for the treatment or prevention of diseases, disorders and conditions, and for use in non-therapeutic treatments. Example of agents which promote brain health include brain protective agents (for example phosphatidylserine, phosphatidylcholine and / or choline), agents that enhance neurotransmission (for example a nootropic, for example ergothioneine, huperzine, aGPC, taurine and / or L-theanine), agents that promote neurogenesis (for example selenium); and brain essential nutrients (example Vitamin B6, B9, B12, magnesium salts, folic acid and / or L-methylfolate). Examples of agent which promote immune health include quercetin, Elderberry or an extract thereof; a selenium salt; and / or a zinc salt.

The application provides a distal filter brain protection device for use in cardiac surgery, comprising a sleeve with an inlet end and an outlet end; the sleeve is divided into 2-3 sleeve branches at the inlet end; the sleeve contains 2-3 implant sheaths; one implant sheath is introduced from each sleeve branch; the implant sheaths are all led out at the outlet end; the implant sheaths are provided with guide wires, and the front ends of the guide wires are provided with umbrella-shaped filter screen devices; the umbrella-shaped filter screen devices are provided with multiple ultrasonic emission balls containing corner reflectors to enhance the ultrasonic reflection effect of the devices. The distal filter brain protection device of the application can simultaneously provide precise filter implantation and removal for multiple blood vessels, especially two carotid arteries, in cardiac surgery, and the implantation and detailed operation process can be completed under ultrasonic monitoring.

The invention relates to the technical field of medical instruments, and provides a pressure-adjustable craniocerebral protective cap in order to solve the technical problems that bandaging after an existing craniocerebral operation cannot be adjusted in time according to craniocerebral pressure, and the pressure cannot be measured and accurately controlled, the pressure-adjustable craniocerebral protective cap comprises a cap body, an opening is formed in the cap body, the opening is of a folded edge design, and a plurality of through holes are formed in the surface of the cap body; an elastic bridle is arranged on the lower edge of the cap body and is used for adjusting the tightness degree of the cap body; the air bag penetrates through the through hole in the surface of the cap body, and the inner side of the air bag is communicated with a human craniocerebral defect area; the pressure adjusting structure is arranged on the outer side of the air bag, communicates with the interior of the air bag and is used for conducting adaptive adjustment when the pressure of the air bag changes. Self-adaptive adjustment can be carried out according to intracranial pressure changes, meanwhile, the device can be tightly attached to a craniocerebral defect area, and intracranial pressure fluctuation caused by factors such as external pressure changes or slight collision of the head is avoided.

The application discloses a database high-availability cluster brain split protection method and device and medium, belongs to the technical field of database high-availability cluster, and is used for solving the technical problems that the existing PostgreSQL high-availability cluster scheme is prone to cluster brain split, mis-switching and data inconsistency problems in network partition and communication anomaly due to the lack of network topology awareness, communication quality quantification, state cross-verification and hierarchical isolation strategy. The method comprises the following steps: after triggering the master selection process of the current cluster, detecting the communicable nodes in the current cluster; performing multi-dimensional quality perception on the communicable nodes to obtain corresponding node state parameters; performing weighted calculation according to the node state parameters to obtain a weighted value; if the weighted value reaches a first preset threshold, performing visibility consensus verification on each communicable node; after the visibility consensus verification is passed, determining a candidate master selection area based on the regional awareness master selection strategy; and selecting a new master node in the candidate master selection area according to the hierarchical response strategy.

The utility model discloses a craniocerebral drainage device, which belongs to the technical field of medical instruments and comprises a drainage catheter, an endoscope system and a guide core system. The drainage catheter is made of a thermoelastic material and is disposable, and the high-light-transmission blocking hole is additionally arranged and is provided with a round corner, so that the imaging effect can be ensured, and brain tissues can be prevented from being damaged; the drainage catheter can be designed into a single cavity or a plurality of cavities, or one cavity has two purposes; the guide core system is subjected to hydrophilic treatment, so that the effects of anticoagulation, lubrication and inflammation reduction can be achieved; the guide core system can be used for replacing a surgical drainage guide steel needle, so that the use is more convenient; the drainage catheter is accurately driven into a hemorrhagic point by utilizing a visual system and a professional craniocerebral drainage control system; the craniocerebral drainage device is simple in structural design, clear in visual field, good in craniocerebral protection effect, safe and effective.

The invention provides a phthalide ring-opening derivative as shown in a formula (I-1) and a stereoisomer or pharmaceutically acceptable salt thereof and application thereof. Experimental results show that the compound disclosed by the invention has excellent pharmacokinetic properties, and the release of butylphthalide and dexcanthanol in vivo is superior to that of single drug butylphthalide and dexcanthanol and is also superior to that of a compound composition. The compound disclosed by the invention has an excellent brain protection effect and can greatly reduce the cerebral infarction area; the compound can be used for preventing and treating nerve injury, degenerative diseases and ischemic diseases. # imgabs0 #

The utility model discloses a brain protection pillow and a cart with the brain protection pillow, the brain protection pillow comprises at least one deformable maintaining part and a pillow part, and the pillow part comprises a bearing unit, two protection units and a containing groove. The two protection units are adjustably arranged on the two opposite sides of the bearing unit respectively, so that the containing groove is formed between the bearing unit and the two protection units and used for containing the head of an infant, and the maintaining part extends from one protection unit to the other protection unit through the bearing unit and is used for maintaining the head of the infant. When force is applied to the protection unit to enable the angle of the protection unit relative to the bearing unit to be adjusted, the maintaining part is stressed and deformed, after external force applied to the protection unit is removed, the maintaining part maintains the angle of the protection unit relative to the bearing unit, and therefore the angle of the protection unit relative to the bearing unit is adjusted. The width size of the containing groove can be adjusted according to needs.

The invention relates to the technical field of medical first-aid equipment, in particular to a device for heatstroke first aid and mild hypothermia treatment. Comprising a foldable cabin body; the composite cooling unit comprises a contact type conduction cooling module, a targeted brain cooling module and an environment convection cooling module; the contact type conduction cooling module is an ice blanket; the targeted brain cooling module is an ice cap, and the environment convection cooling module comprises a cold air inlet formed in the top end of the cabin body, an air outlet formed in the bottom of the cabin body and refrigeration equipment connected with the cold air inlet; and the intelligent monitoring and control unit is connected with the ice blanket, the ice cap and the refrigeration equipment and used for adjusting the temperature of the ice blanket and the ice cap and the cold air output power of the refrigeration equipment. The device provided by the invention integrates cooling, monitoring and brain protection functions, is efficient and cooperative in cooling and accurate in temperature control, can have a brain protection effect, improves the treatment safety, is light and portable, and is suitable for complex environments without fixed medical facilities, such as fields and battlefields.

The application discloses an intraoperative brain protection device, which comprises an elastic support and a filter screen; the elastic support can be self-inflated on the inner wall of a blood vessel of an aortic arch and is attached to the inner wall of the blood vessel of the aortic arch, the elastic support is a ring-like structure surrounded by an elastic metal material, the distal end and the proximal end of the ring-like structure are upwardly curved to fix the intraoperative brain protection device in the aortic arch; the filter screen is located in the area surrounded by the elastic support, and the two ends of the filter screen are connected with the distal end and the proximal end of the ring-like structure respectively to block the thrombus generated in the operation from entering the head artery. The protection device adopts a left subclavian artery approach, compared with a traditional femoral artery protection device, the influence of other femoral artery access instruments on the femoral artery is reduced, the operation effect is guaranteed, and the application of the intraoperative brain protection device in the medical instrument technical field is facilitated.

The utility model discloses a sheathing canal of a multi-conveying system, which comprises a main body tube provided with an intracavitary section inserted into a blood vessel cavity when in use; the main body tube is provided with three selectable independent cavities, the input port of one cavity is set as a third input end, the input ports of the other two cavities are set as a first input end and a second input end, and the first input end, the second input end and the third input end are all exposed outside the body; the intracavitary section is provided with a left output end and a right output end which respectively correspond to the input end I and the input end II, the input end I and the left output end form a passage, the input end II and the right output end form another passage, and the left output end and the right output end respectively correspond to the positions of a left common carotid artery and a right common carotid artery in an operation; the third input end is used for guiding the supporting guide wire to be inserted into the cavity corresponding to the third input end so as to fix the main body pipe. The purpose of placing the brain protection umbrellas on the two sides at the same time is achieved, the use range of the sheathing canal is expanded, and operation efficiency is improved.

The present application relates to a vincamine derivative, a preparation method therefor, and use thereof, and belongs to the technical field of preparation of vincamine derivatives. The vincamine derivative has the following advantages: (i) Modification of the tail chain increases the lipid solubility of vincamine compounds without affecting the cerebral blood flow regulation of vincamine itself, thereby helping the carried drug penetrate the blood-brain barrier, exert a brain-protective effect, and improve cerebral microcirculatory disorders. (ii) The tertiary amine group in the parent nucleus structure of the vincamine derivative is ionizable under acidic conditions, which enables efficient delivery and lysosomal escape of nucleic acid drugs through charge adsorption, thereby improving intracellular transport. (iii) The vincamine derivative inherits various pharmacological activities inherent to vincamine, and has high safety. Therefore, the vincamine derivative has good application prospects in brain-targeted delivery of drugs for treating brain diseases.

This invention provides a composite composition containing nervonic acid and its use in brain nerve repair, belonging to the field of biotechnology. The invention uses nervonic acid and phosphatidylserine, combined with plant extracts fermented by a microbial concoction of *Lactobacillus acidophilus*: *Lactobacillus rhamnosus*: *Bacillus belyssae* = (2-3):1:1, to form a composite composition. This scientific formulation achieves synergistic effects from multiple components, improving neurological deficits, reducing cerebral infarction volume, decreasing the release of neurotrophic markers, and upregulating neurotrophic factor expression through multi-target synergistic effects. Furthermore, this synergistic effect depends on specific component ratios, providing crucial experimental support for the development of subsequent brain-protective functional compositions. This composition can be widely applied to the preparation of brain nerve repair drugs, functional foods, and dietary supplements, possessing promising industrialization prospects and clinical value.

The invention discloses an edible and medicinal composition with effects of lowering lipid and protecting heart and brain as well as a preparation method and application of the edible and medicinal composition, and belongs to the technical field of functional foods. The food and medicine homologous composition is prepared from three food and medicine homologous raw materials including broccoli seeds, lucid ganoderma and radix puerariae. Broccoli seeds are heated, dried and smashed, and broccoli seed powder is obtained; the preparation method comprises the following steps: uniformly mixing crushed lucid ganoderma, radix puerariae and broccoli seed powder according to a ratio, heating and extracting, concentrating the obtained filtrate, and carrying out spray drying to obtain a core composition; and adding the auxiliary active composition into the core composition, and uniformly mixing to obtain the edible and medicinal composition with the effects of lowering lipid and protecting heart and brain. The food and medicine homologous composition can be prepared into a multi-layer tablet with a core / shell structure, and the multi-layer tablet can be eaten as a functional food or health-care food with the functions of reducing blood fat, resisting oxidation or protecting heart and cerebral vessels. Animal experiments and crowd feeding trials show that the composition has the effect of regulating the overall metabolism of the body, can reduce the blood fat level and regulate intestinal flora, and has a good auxiliary relieving effect on symptoms of cardiovascular and cerebrovascular related diseases.

The application relates to the technical field of sports protective equipment, and discloses a buffering electronic head protector for taekwondo, which comprises a head protector main body, a buffering protection assembly and a sensing system, the head protector main body comprises a head protection part and a back brain protection part, an adjusting gap is formed in the bottom of the back brain protection part, adjusting belts are connected to the two sides of the adjusting gap, a drag tongue is arranged in the middle of the adjusting gap, the drag tongue is perpendicular to the length direction of the adjusting belt, the end of the drag tongue is integrally formed with the head protector main body, and the drag tongue is located on the side of the adjusting belt which faces the inside of the head protector main body. The application has the effect of improving the comfort of the wearer.

The invention relates to the technical field of medical instruments, in particular to a pediatric anesthesia brain protection constant-temperature infusion device based on low-temperature intervention and a using method.The pediatric anesthesia brain protection constant-temperature infusion device is characterized in that a limiting mechanism is arranged in a mounting box, a temperature increasing mechanism is arranged outside the middle of the mounting box, and a protection mechanism is arranged on one side of the temperature increasing mechanism; the medical infusion bottle hanging device has the beneficial effects that a screw rod and a screw sleeve are matched to drive a supporting rod and an opening box to move to a proper height, so that different medical workers are matched to hang infusion bottles, the infusion bottles of different specifications can be clamped, the medical workers can conveniently use the medical infusion bottle hanging device, and the overall hanging flexibility is improved; a transmission wheel and a belt are arranged to drive a two-way lead screw and a lead screw nut, so that a pipeline is rapidly clamped, temperature control is conveniently conducted through a second clamping plate and a heating piece which are externally connected with control equipment, meanwhile, the pipeline is conveniently limited through third clamping plates at the two ends, shaking caused by external force is prevented, and the overall stability is improved.

The invention discloses an application of a TLR3 receptor agonist Poly (I: C) in preparation of a neuroprotective agent drug for Alzheimer's disease. Belongs to the technical field of Alzheimer disease medicines. The TLR3 agonist Poly (I: C) is used for preparing the Alzheimer disease neuroprotective agent medicine to play a brain protection role in Alzheimer disease, specifically, the TLR3 agonist Poly (I: C) is used for removing deposition of Abeta1-42 in the brain, reducing Abeta1-42 in plasma and improving encephalatrophy, and meanwhile, the learning and memory ability of mice with the Alzheimer disease can be remarkably reduced.

The utility model belongs to the technical field of medical instruments, and provides a controllable nasal cavity cooling brain protection device, which comprises a cooling mechanism, a nasal cavity cooling mechanism and a nasal cavity cooling mechanism, and the nasal cavity cooling mechanism comprises a pressurizing cooling tank and an intubation tube assembly which is provided with at least one hose capable of being inserted into the nasal cavity and a flow regulating valve; the temperature measuring mechanism is provided with at least one temperature measuring probe capable of extending into the auditory meatus tympanic chamber; and the control mechanism is used for adjusting the conveying flow of the cooling spray through the flow adjusting valve according to the tympanic membrane temperature data detected by the temperature measuring probe. The controllable cooling brain protection device in the nasal cavity is convenient to carry, can be used for carrying out brain hypothermia treatment protection on site or in the transportation process, shortens the intervention opportunity of hypothermia treatment on a patient, reduces brain tissue damage caused by brain temperature rise, improves the neurological function prognosis condition of the patient, and meanwhile, can be used for protecting the patient. The brain temperature change is monitored in real time through the temperature measuring mechanism, and the conveying amount of the cooling spray is adjusted according to feedback, so that the brain temperature is maintained at a constant level.

The application relates to the technical field of medical devices, in particular to a brain protection filter assembly, which comprises a first frame body and a second frame body connected with the first frame body, and an anchoring part is arranged on the second frame body and used for connecting and positioning when the brain protection filter assembly is recovered; in the application, the above-mentioned brain protection filter assembly is used, the covering positions of the first frame body and the second frame body are matched, foreign matters in the head-arm trunk artery, the left common carotid artery and the left subclavian artery can be filtered at the same time, the aortic arch is comprehensively covered, the anchoring part arranged on the second frame body is used for connecting and positioning when the brain protection filter assembly is recovered, the brain protection filter assembly can be freely recovered in the patient's body after operation, the foreign matter capturing time is prolonged, and the efficiency of preventing stroke is improved.