80 results about "Brain protection" patented technology

The invention relates to the field of medicine, and discloses a novel application of stilbene compounds in preparation of drugs for curing ischemia stroke in the acute phase. The effective time windows of rhubarb stilbene glucoside and piceatannol can last for 6 hours; the rhubarb stilbene glucoside and piceatannol can decrease the water content in the rat brain tissues during the cerebral ischemia process of a rat, and improve the rat nerve function scores. The mechanism is that rhubarb stilbene glucoside and piceatannol have strong functions of oxidation resistance and clearance of oxygen free radicals, and have a brain protection function. The piceatannol has stronger functions of oxidation resistance and clearance of oxygen free radicals than those of the rhubarb stilbene glucoside in vitro. So the invention provides applications of rhubarb stilbene glucoside and piceatannol in preparation of drugs for curing ischemia stroke in the acute phase.

The invention discloses injection of mannite and glycerol, which contains mannite, glycerol and water for injection. Furthermore, the invention also discloses a method for preparing the injection, which comprises the following steps: taking the mannite and the glycerol, dissolving into the water for injection, filtering and filling. The injection of the mannite and the glycerol is clinically used for treating cerebrovascular diseases, brain trauma, cerebral tumors, intracranial inflammation and the diseases of acute and chronic intracranial hypertension, hydrocephalus and the like caused by other reasons. The injection of the mannite and the glycerol has the functions of lowering the intracranial pressure quickly and eliminating the hydrocephalus and can also avoid death because of acute renal failure caused by the injury of the kidney; the injection of the mannite and the glycerol suppresses the apoptosis of neural cells and achieves the function of protecting the brain; the function of lowering the intracranial pressure is stable and has long retention time; crystals occurring because of the change of the air temperature or in the processes of storage and transportation are eliminated; and the glycerol is used as a caloric agent and can improve and recover the energy metabolism of the important viscera of the heart, the brain, the kidney and the like during oxygen deficiency. The injection of the mannite and the glycerol is a very effective, stable and safe medicine for promoting urination and removing water clinically.

The invention discloses a craniocerebral local low-temperature automatic temperature control device. The device carries out thermoelectric conversion through a temperature detecting circuit by adopting combination of multiple points of sensitive thermocouple sensors, controls the rotating speed of a miniature step motor through a control circuit after an acquired signal is gated through an inspection circuit, thereby controlling instant flow rate of cooling fluid of a closed loop, realizing middle depth low-temperature state in a local surgery zone, and automatically maintaining the surgery zone and peripheral tissues at a certain constant temperature to meet the requirement of a surgery. The whole process can quickly cool, and can reduce the temperature to the temperature required in the surgery in only 3 to 5 minutes after tests. The device not only can cool the middle depth zone in local part, has adjustable temperature, and maintains constant temperature, but also can form a temperature gradient graph in the brain, and has significance for evaluating the effect of low-temperature brain protection.

A sublow-temp cerebral protecting and therapeutic apparatus with semiconductor refrigeration is composed of a point-type temp sensor arranged in blood vessel, a constant-temp device for outputting sublow-temp perfusion and delivering it via blood vessel into cerebral region, a controller for the closed-loop control to the temp of perfusion, and a power supply. It can decrease the complications.

The invention relates to a disintegrated tablet of carthamin yellow carthamus with functions like dilation of the coronary arteriae, antioxidation, tomyocardium protection, blood pressure decrease, immunodepression and brain protection and its preparing technique. It is aiming at advancing the present the preparation kind of carthamin yellow carthamus, supplying a disintegrated tablet of carthamin yellow carthamus with convenient use and rapid effect and its preparing technique. Using carthamin yellow carthamus as raw material, bulking agent, disintegrating agent, taste reclaiming agent, glidant and lubricant as auxiliary materials, and adding into suitable quantity of effervescent granules or using adhesives or packaging material in accordance with different condition, through the special preparing method, use tablet press to acquire the product. The invention has rapid, good taste, without feeling like sand in mouth, does not need special producing condition; it has characteristics like low cost, convenient storage, transportation and disintegration, especially, it can be disintegrated without drinking water and conformity has rapid effect, advancing sicker's conformity and increasing medicine curative effect.

The invention belongs to the field of pharmacy and relates to a new application of a traditional Chinese medicine motherwort extract in pharmacy, in particular to the application of the purified motherwort extract in preparing nerve protection medicine for treating cerebral injury, especially the application of the purified motherwort extract in preparing brain protection medicine for treating artery obstruction in the brain. By an animal experiment of the purified motherwort extract, a result indicates that the brain stem volume is obviously reduced after the purified motherwort extract is applied, the obstacle grading of the nerve function is decreased by being compared with a contrast group, the total antioxidant concentration in plasma is increased, the DNA oxidation injury is reduced, the expression levels of apoptosis and apoptosis promoting protein are reduced, and the content of apoptosis resistance protein is also increased. The purified motherwort extract can be used for preparing the nerve protection medicine for treating the cerebral injury and can effectively treat cerebral apoplexy.

The invention relates to the medical field, in particular to a compound brain protection preparation and a preparation method thereof. The preparation contains active pharmaceutical ingredients and pharmaceutically acceptable carriers, wherein the active pharmaceutical ingredients comprise edaravone and nimodipine according to a mass ratio of 2-30: 1-3. The preparation can protect the brain by acting on a plurality of links of cerebral injury through different mechanisms. Compared with the single pharmaceutical preparation, the preparation can better prevent and cure associated cerebrovascular diseases.

The present invention discloses a medicine having a brain protection effect, and a preparation method thereof, wherein the active ingredient is ginkgolide L, and the ginkgolide L has a brain protection effect, wherein the brain protection effect specifically comprises effects of platelet aggregation inhibiting and nerve protection after stroke.

The invention belongs to biological medical and biological technology field. It relates to a vascular endothelia growth factor(VEGF) plasmid-liposome complex and its usage in the preparation of the pharmaceutical composition, in particular to the usage of VEGF plasmid-liposome complex in preparing pharmaceutical composition for treating cerebral ischemia injury, promoting differentiation of the adult cranial nerve stem cells and regenerating of the nerve cells. The complex of the VEGF and liposome is proved by the local cerebral ischemia animal model that said complex expresses highly of VEGF with only once injection, having no need of infusing for long period of time, having biological effects of brain protection and adult cerebral nerve stem cell differentiation promotion and regeneration of the nerve cell without the virus infection.

The invention relates to a pharmaceutical composition of ginsenosides RG5 and RZ1 and application of the pharmaceutical composition in brain protection. Active components of the pharmaceutical composition are the ginsenosides RG5 and RZ1 and can be used for preparing a medicine for the brain protection. A pharmaceutical preparation provided by the invention contains the pharmaceutical composition of the ginsenosides RG5 and RZ1 and pharmaceutically-acceptable carriers, and is prepared into pharmaceutically-acceptable dosage forms; the pharmaceutically-acceptable carriers comprise one or more of solids, semisolids or auxiliary liquid materials; the pharmaceutically-acceptable dosage forms comprise injections, tablets, capsules, granules, pills, syrup, powder and ointment. In the pharmaceutical composition provided by the invention, the ginsenosides RG5 and RZ1 have an effect of mutually promoting the permeability of a blood brain barrier; the permeability of the blood brain barrier of the ginsenosides RG5 and RZ1 is remarkably higher than that of single ginsenosides RG5 or RZ1, therefore, the ginsenosides RG5 and RZ1 can be combined for a drug.

The invention relates to novel application of stachydrine hydrochloride, in particular to application of stachydrine hydrochloride in the preparation of drugs, foods or health products to prevent andtreat ischemic cerebrovascular diseases. Pharmacological tests via a rat focal cerebral ischemia model verify that the stachydrine hydrochloride is capable of evidently lowering area percentage of brain injury due to focal cerebral ischemia caused by rat suture occlusion, evidently improving post-ischemic neural behaviors of a rat, increasing the SOD content in serum and lowering MDA content. Thestachydrine hydrochloride has great brain protection; with low molecular weight, the stachydrine hydrochloride has significant brain permeability. The stachydrine hydrochloride is well applicable to the prevention and treatment of ischemic cerebrovascular diseases.

The invention discloses an intraoperative brain protection device which comprises an elastic support and a filter screen. The elastic support can expand on the inner wall of a blood vessel of the aortic arch and is attached to the inner wall of the blood vessel of the aortic arch, the elastic support is of a ring-like structure defined by elastic metal materials, and the far end and the near end, in the axial direction, of the ring-like structure tilt upwards so that the intra-operative brain protection device can be fixed in the aortic arch; the filter screen is located in an area defined by the elastic support, and the two ends of the filter screen are connected with the far end and the near end of the ring-like structure respectively so as to prevent thrombus generated in the operation from entering the head artery. The protection device adopts the left subclavian artery approach, and compared with a traditional femoral artery protection device, the influence that other femoral artery approach instruments jointly occupy the femoral artery is reduced, the operation effect is guaranteed, and popularization and application of the intraoperative brain protection device in the technical field of medical instruments are facilitated.

The invention discloses a prescription and a preparation method of a pH-stable pentoxifylline injection. The prescription is composed of pentoxifylline, sodium chloride, L-lysine and water for injection, and the dosage of the L-lysine is 3-7 mg/ml. After the L-lysine (pH 5.5-6.0) is added, the pH value of the pentoxifylline injection is more stable, and the L-lysine serving as a brain protective agent for systemic brain trauma, chronic tissue ischemia and ischemic diseases has a synergistic effect with the pentoxifylline, so that the effect of pentoxifylline for improving the blood flow volume of the brain and improving nutritional microcirculation of the body and oxygen supply of an ischemic area are improved. The pentoxifylline injection disclosed by the invention is simple and efficient in prescription process and good in safety.

The invention provides application of a Tibetan medicine eighteen-ingredient medicine terminalia fruit diuresis pill and a brain protection effect method of the pill on a rat with type 2 diabetic encephalopathy. Through the practical molding operation of a diabetic encephalopathy model in a high altitude area, the invention provides a novel application path of an old medicine. The Tibetan medicineeighteen-ingredient medicine terminalia fruit diuresis pill is clinically used for treating diseases such as diabetes, nephropathy, frequent micturition and waist and kidney pain. The Tibetan medicine eighteen-ingredient medicine terminalia fruit diuresis pill is found to also achieve a certain protection effect on the diabetic encephalopathy.

The invention relates to the technical field of large bone flap decompression, and discloses a large bone flap decompression postoperative temporary brain protection device which comprises a first protection shell and a second protection shell, a top shell is arranged at the upper end of the first protection shell and the upper end of the second protection shell, and air bag layers are arranged on the inner side faces of the first protection shell, the second protection shell and the top shell. A first magnetic sheet is embedded in the upper surface of the first protective shell, a fixing box is arranged on the front surface of the first protective shell and located below the front groove, and a loudspeaker is embedded in the front surface of the first protective shell and located on one side of the fixing box. The wearing comfort of patients with different head sizes is met through the gas injection amount of the air bag layer, meanwhile, oxygen and food supply of the patients can be met through the design of the fixing box and the oxygen uptake cover, doctors or family members can conveniently understand the requirements of the patients in time through cooperation of the microphone and the loudspeaker, help is provided for the patients, operation is easy and convenient, and practicability is high. The functionality is high.

The invention relates to the technical field of medical apparatus and instruments, in particular to a cerebral monitoring protection cap and a cerebral monitoring method and system. The cerebral monitoring protection cap comprises a cap body, a monitoring component, a bag and a communication component; the bag is movably arranged on the inner side of the cap body; the monitoring component is in wired or wireless connection with the communication component, and data obtained through monitoring of the monitoring component is sent through the communication component. After brain decompressive craniectomy, the cerebral monitoring protection cap is worn on the head of a patient, the communication component sends the data obtained through monitoring to a terminal, a clinician can know the braincondition in real time through the data of the terminal, real-time monitoring of the brain is achieved, the brain monitoring protection cap can protect the brain against the influences of factors suchas the external atmospheric pressure, and effective brain protection is achieved.

The invention discloses an examination protecting and fixing device used for children in the radiology department. The examination protecting and fixing device comprises a device body, wherein the device body comprises a brain protection device, a leg fixing device, a sliding device, a sexual gland protection device and a chest fixing device; a groove is arranged below the brain protection device;one side of the groove is provided with a soft cushion; the chest fixing device is arranged above the soft cushion; one side of the chest fixing device is provided with the sexual gland protection device; the bottom of the sexual gland protection device is connected with the sliding device; in addition, one side of the sliding device is provided with the leg fixing device; the chest fixing devicecomprises a second bandage collection box, a second rolling shaft, a third fixing block, a second bandage, a second clip, a second clamping block box and a fourth fixing block; and in the second bandage collection box, the second rolling shaft is arranged, while a child can be conveniently and effectively fixed, the sensitive positions, including the sexual gland, the head, the eyes and the like,of the child can be favorably protected to reduce radiation injuries to the child.

The invention relates to a preparation method of a brain protective agent and key impurities thereof. According to the invention, phenylhydrazine and ethyl acetoacetate serve as raw materials, edaravone and three key impurities of edaravone are synthesized in the same route, wherein the three key impurities include a transition-state impurity, edaravone dimer nitrogen oxide and 5-methyl-2-phenyl-4-(propyl-2-iene)-2,4-dihydro-3H-pyrazol-3-one; compared with respective synthesis of edaravone and each impurity, the method has the advantage that time and cost are saved; and experiments prove that the method of preparing edaravone by firstly controlling the process for synthesizing the transition-state impurities and then changing the process are higher in the yield and the purity of edaravone compared with direct synthesis of edaravone.

The invention relates to the technical field of medicine, food, reagents and the like, in particular to application of oligopeptide GRGDS in preparation of a drug for preventing and treating ischemiccerebrovascular diseases. Pharmacological tests of a rat local cerebral ischemia model show that the oligopeptide can significantly reduce the cerebral infarction volume of a cerebral ischemia rat, significantly improve the nerve injury of the rat after ischemia and reduce the apoptosis of nerve cells. The oligopeptide has a strong brain protection effect, is easy to penetrate through a blood brain barrier due to small molecular weight, and has remarkable advantages. Therefore, the oligopeptide GRGDS has good application prospects in preparation of the drug for preventing and treating ischemiccerebrovascular diseases.

The invention discloses application of 4-methoxybenzyl alcohol in the preparation of TRMP7 inhibitor drugs and further discloses application of 4-methoxybenzyl alcohol in the preparation of brain protection drugs. The 4-methoxybenzyl alcohol is capable of inhibiting expression of TRMP7 and is a TRMP7 inhibitor, capable of lowering concentration of calcium ions in nerve cells, increasing survival rate of the nerve cells and preventing and/or treating hypoxia-caused brain injuries; the 4-methoxybenzyl alcohol can be prepared into brain protection drugs to prevent and/or treat ischemic cerebrovascular diseases and has a promising clinical application prospect.