109 results about "Critical illness" patented technology

A system and method for allowing an individual to accumulate wealth faster in the event of an adverse personal consequence, such as a death, a disabling accident or a critical illness. The system and method includes issuing an asset accumulation product and an insurance rider that guarantees an increase in the yield of the asset accumulation product upon the occurrence of an adverse personal event.

The invention discloses a method for highly sensitive quantitative detection of quantum dot fluorescence immunochromatographic assay. The method includes: building a fluorescence immunochromatographic assay test strip on the basis of optimizing the structure of the test strip and components by the aid of excellent fluorescent characteristics of quantum dots and by means of combining quantum dot fluorescence labeling technology and immunochromatographic assay; detecting fluorescence signal strength of a quantitative belt and a quality control belt by the aid of a fluorescence quantometer and correcting the fluorescence strength of the quantitative belt by the aid of the quality control belt after immunochromatographic assay of the test strip; and further quantitatively detecting analyte according to a standard curve obtained by the fluorescence quantometer. The method is simple, rapid, accurate, low in cost and quite high in sensitivity. Compared with a conventional colloidal gold immunochromatographic assay method, the method has the advantages of fine labeling stability, low non-specificity, high sensitivity, wide linear range and accuracy in quantization. The method is applicable to samples such as blood samples, urine samples, spittle, excrement and the like, and can be applied to detection of critical illness, poison, food safety and the like.

The invention discloses a critical care, transfusion control, and diagnosis and treatment integrated system and a control method thereof. The system comprises a transfusion device, a transfusion care base station, a central monitoring server and a medical PDA, wherein the transfusion care base station forms a transfusion scheme and performs open-loop control on the transfusion device by a wireless or wire mode, or adjusts transfusion parameters according to a corresponding closed-loop algorithm by monitoring and analyzing physiological parameters of patients during the transfusion execution, and performs closed-loop control on the transfusion device by the wireless or wire mode; the central monitoring server is connected with the transfusion care base station by the wireless or wire mode and monitors the operating state of the transfusion care base station; and the medical PDA is connected with the transfusion care base station and/or the central monitoring server by the wireless mode and is used for displaying transfusion condition and managing transfusion process. The system organically combines a treatment means (venous transfusion) and the effect of the treatment means (the monitoring of the physiological parameters) into one system, thereby realizing the closed-loop control of one or more transfusion devices, and improving medical quality and work efficiency of medical personnel.

The invention discloses human body oxidative stress non-invasive fluorescence detection device and method. An excitation light source system comprises one near ultraviolet light source and one light filter and one beam splitter which are arranged on the emergent light path of near ultraviolet light source; wherein the beam splitter splits the emergent light into a reference light and an exciting light. A spectrum acquisition system comprises a conduction optical fiber, a fiber probe and a spectrometer. The conduction optical fiber is used for transmitting the reference light to the spectrometer; the fiber probe is used for transmitting the exciting light to skin part of human body to be tested, collecting fluorescent light generated by excitation on skin of human body and transmitting the fluorescent light to the spectrometer. The spectrometer is used for analyzing and processing the collected spectrum signal and finally obtains oxidative stress status of the detected object. Autofluorescence of skin is utilized to reflect human body oxidative stress status, detection speed is rapid, and result can be displayed in real time. The invention can provide reliable basis for prevention, diagnose and treatment effect evaluation on critical illness.

The invention belongs to the technical field of computers, and relates to a rehabilitation therapy determination method and device, a computer readable storage medium and electronic equipment. The method comprises the following steps: acquiring a target index and an object identifier, and sending a parameter acquisition request carrying the object identifier; receiving a target index parameter corresponding to the target index based on the parameter acquisition request; inputting the target index parameter into a pre-trained machine learning model to enable the machine learning model to outputa target therapy; obtaining an evaluation standard corresponding to the target index, and if the target index parameter does not meet the evaluation standard, generating early warning information corresponding to the target therapy; and adjusting the target therapy according to the early warning information so as to carry out corresponding rehabilitation training. On one hand, medical staff monitor target index parameters of an object in real time and know the health condition of the object; on the other hand, accurate treatment measures and methods are recommended to medical staff, passive rescue is changed into active intervention treatment, and great influences are achieved on prevention against serious diseases.

The embodiment of the invention provides a disease prediction method and device, a medium, and electronic equipment. The method comprises the steps: obtaining the data, correlated with health, of a plurality of users; carrying out the clustering analysis of the plurality of users based on the data, correlated with the health, of the users, so as to dividing the users into at least one class; determining a target class where a diagnosed patient belongs, and predicting other users in the target class as a high-risk group of diseases. According to the technical scheme of the invention, the methodcan achieve the prediction of the group which may have diseases, can guarantee the timely finding of severe diseases, so as to find and treat a disease early, and improve the level of health management of users.

The present invention relates to a method for identifying human health status based on BP neural network, comprising the following steps: S1, processing the actual measured values ​​of physiological, psychological and behavioral indicators of people who do not suffer from major diseases to obtain the normalization of each indicator value; S2, BP neural network structure initialization; S3, BP neural network recognition training; S4, measure and test the human body to be recognized, and obtain the actual measured value of the selected human body index; S5, use the trained BP neural network to carry out Health status identification. The present invention effectively fuses multiple physiological, psychological, and behavioral index values ​​that reflect the health status of the human body, and provides the health status identification results through the BP neural network model, which not only makes the identification results of the health status of the human body simpler and more intuitive, but also The evaluation results can enable non-professionals to clearly and clearly understand their own health status, and have important guiding significance for the adjustment of human-related life activities and even the prevention and treatment of diseases.

The present invention discloses for the first time that the insulin receptor (IR) is a target of Herstatin, which modulates IR and IR-mediated intracellular signaling. In preferred aspects, Herstatin binds at nM concentrations to cell-surface IR, up-regulates basal IR expression by several-fold, induces the accumulation of pro-IR, and stimulates insulin activation of the ERK pathway. Moreover, these changes in insulin signaling are accompanied by alterations in IGF-IR expression, IRS-2 levels, and the serine phosphorylation state of both IRS-1 and IRS-2. Preferred aspects provide novel therapeutic methods and pharmaceutical compositions for treatment of conditions associated with altered IR expression or IR-mediated signaling, including but not limited to insulin resistance syndrome, pre-diabetic conditions, metabolic syndrome, type 1 and type 2 diabetes, cardiac disease, diabetes-associated vascular disease, atherosclerosis, hypertension, diabetes-associated lipid metabolism disorders (dyslipidemia), obesity, critical illness, neurodegenerative disorders, and combinations thereof, and cancer.

The invention discloses a cardiovascular and cerebrovascular disease therapeutic apparatus capable of positioning function recovery therapy, preventing hypertension and cardiovascular and cerebrovascular diseases, and carrying out clinic therapy and first-aid, which consists of an oxygen inhalation horizontal exerciser and a massager and utilizes physical and chemical medicine combination treatment; the oxygen inhalation horizontal exerciser consists of a bed body, an oxygen inhalation device and a rotary wheel, for oxygen inhalation, respiratory administration, recovering abdominal breathing function and reducing blood pressure, which is combined with medicine oral administration, and the massager comprises medicine cloth and a massage head for medically massaging rigid muscle and activating blood, which is combined with local medicine injection; the invention is based on treatment principle and method of serious diseases, aims at the cause of hypertension and cardiovascular and cerebrovascular diseases to be function reduction and structural damage which are restricted by each other, and integrates function recovery with existing treatment of medicine, operation, and bypass grafting injury protection which can promote one another. The invention can cure cardiovascular and cerebrovascular diseases by treatment of disease cause.

The invention belongs to the field of pharmaceutical chemistry and relates to a 1, 2, 3-triazole compound, comprising 4-(2-bromophenyl)-1H-1, 2, 3-triazole and 4-(2-chlorphenyl)-1H-1, 2, 3-triazole. The result of an inhibitory activity test of indoleamine 2, 3-dioxygenase indicates that the disclosed 1, 2, 3-triazole compound used as the indoleamine 2, 3-dioxygenase inhibitor has broad prospect of application and can be applied to the treatment of diseases with indoleamine 2, 3-dioxygenase-mediated tryptophan metabolic pathway pathological characteristics, including cancer, AIDS (Acquired Immure Deficiency Syndrome), Alzheimer disease, tristimania, cataract and other critical diseases.

The present invention discloses a Beidou-based emergency helicopter navigation positioning system and a navigation positioning method thereof. Based on the characteristics of the Beidou system, namely high-precision navigation and two-way short message communication, the landing site of an emergency helicopter can be quickly found out with the assistance of the GIS vector map technology and the image processing technology. Meanwhile, the functions of planning an optimal route, navigation, remote monitoring the life indexes of a patient and the like are realized. Based on the system and the method, the precious rescue time of gold is provided for the helicopter emergency operation on patients with critical illnesses and critically wounded patients during emergent events. Meanwhile, the conditions of patients can be known for the working personnel at hospital, so that the working personnel at hospital can prepare surgeries in advance. Therefore, the success rate of rescue is greatly improved.

The invention discloses a device for predicting the critical illness of a COVID19 patient, and belongs to the intelligent processing technology of medical data. The system comprises an input module used for inputting patient information; the data preprocessing module is used for carrying out data preprocessing on the data output by the input module, sending a processing result to the feature selection module if the data is training data, and sending the processing result to the prediction processing module if the data is to-be-predicted data; the feature selection module is used for selectinga certain number of features from the input features as input feature selection results; and the prediction processing module is used for inputting the characteristic information of the patient into apreset prediction model and sending a prediction result to the prediction result output module for visual output. According to the method, key features are selected from the blood detection result ofthe patient so as to guarantee the prediction accuracy of the critical illness of the COVED19 patient, medical assistance for quickly shunting the patient suffering from the COVED19 is achieved, medical resources can be optimized, and medical intervention can be conducted in time.

The invention provides a stepwise multivariable regression model for predicting diseased survival time and application thereof. Whether to introduce a new variable or delete an original variable is judged by constructing an F statistic in the stepwise multivariable regression model, and after introduction of each new variable, whether to delete one variable is judged, that is, whether the newly-introduced variable is associated with the original variable is verified; when the fitting coefficient is greater than 0.8, the fitting effect is relatively good. The stepwise multivariable regression model has relatively wide application to prediction of the survival time of patients suffering from cancers and serious diseases similar to the cancers.

A digital disease control information integration and intelligent public health management platform comprises a management platform server, a database server, an OA office system, a disease surveillance system, an inspection report system, a medical information system, a child preventive vaccination management system, an internal network, an external network, a child preventive vaccination outpatient department, a disease surveillance terminal, a health hazard factor monitoring terminal, a serious disease special reporting system, a public health emergency commanding system, an expert system, a medical information workstation, a monitoring terminal, a testing laboratory, a subordinate unit system, a superior unit system and an information searching and publishing system. All disease data collection and the whole data monitoring of diseases are achieved, and data samples can cover all people and the whole periods of the diseases. Dynamic quality control management is achieved, and therefore management quality and the accuracy of the data are guaranteed, quality control cost and administrative management cost are lowered, and disease prevention and management efficiency is improved.

The invention provides a biosensor for detecting Hg<2+> and a preparation method thereof, which can be used in the fields of environmental monitoring, medical treatment and public health, food safety, life sciences and the like. According to the biosensor, a gold nanocage is combined with a Hg<2+> recognition probe by utilizing a surface positive charge modification technique and electrostatic interaction, so that a nanocarrier with a molecular biological door is constructed, and a single-stranded DNA molecular door which is rich in T basic groups is opened through specific molecular recognition reaction, so that fluorescent molecules are released, and the detection of fluorescent signals is realized. Therefore, by utilizing the biosensor, the high-sensitivity and high-selectivity detection of Hg<2+> can be realized. Additionally, on the basis of a controlled release technique of guest molecules in the nanocarrier of the biosensor, a new way and method is provided for the delivery of tumor targeted drugs and the clinical diagnosis and treatment of serious diseases.

Proposed are a parametric, event-driven critical illness insurance system based on a resource-pooling system (1) and method for risk sharing of critical illness risks of a variable number of risk exposure components (21, 22, 23) by providing a dynamic self-sufficient risk protection for the risk exposure components (21, 22, 23) by means of the resource-pooling system (1). The resource-pooling system (1) comprises an assembly module (5) to process risk-related component data (211,221,231) and to provide the likelihood (212, 222, 232) of said risk exposure for one or a plurality of the pooled risk exposure components (21, 22, 23, . . . ) based on the risk-related component data (211, 221, 231). The risk exposure components (21,22,23) are connected to the resource-pooling system (1) for the pooling of their risks and resources, and wherein the resource-pooling system (1) comprises an multiple event-driven core-engine (3) with critical illness triggers (31, 32, 33) triggering in a patient dataflow pathway (213,223,233) to provide risk protection for a specific risk exposure component (21,22,23). The operation of the resource pooling system (1) is further supported by a parametric risk-cover related to multiple occurrences of critical illness parameters 71,72,73 triggered in the related patient data flow pathway (213, 223, 233).

The invention discloses a rapid detection kit for myocardial infarction. The kit comprises a cardiac troponin I (cTnI) detection reagent, a cardiac troponin T (cTnT) detection reagent and a heart-type fatty acid-binding protein (H-FABP) detection reagent. According to the rapid detection kit disclosed by the invention, three indexes are simultaneously used and are integrated together to prepare the kit, and the kit is convenient to carry and simple in detection process; by simultaneously rapidly detecting cTnI, cTnT and H-FABP, AMI can be diagnosed or eliminated within 1 hour after disease attack, disease attack stages can be determined, the critical illness degree can be evaluated, and the advantages of bedside and on-site rapid applications can be achieved; AMI can be confirmed or eliminated in a very early stage, risk stratification can be achieved, and the purpose of monitoring AMI in the whole course can be achieved; and by virtue of triple detection, a maximum detection time window of AMI can be provided, and high sensitivity and relatively strong specificity (avoiding false positive) can also be achieved.

The invention relates to an online-internal-extraction electrospray-ionization mass-spectroscopy detection device for rapidly analyzing body fluid samples of a human body, and belongs to the technical field of chemical analysis. The detection device consists of an eluate introduction device, an in-situ sample enriching extractor, a sample introduction device, an electrospray ionization source and a mass spectrograph, wherein the eluate introduction device is used for introducing a flowing phase for sample eluting, the in-situ sample enriching extractor is used for carrying out sample loading and online extracting and enriching, the sample introduction device is used for introducing eluted samples into the electrospray ionization source for electrospraying, and the mass spectrograph is used for carrying out detection and analysis on online samples, so as to obtain mass-spectroscopy molecular fingerprint spectrogram information on the samples. According to the detection device, the detected human body fluid samples may be human body fluids such as blood, urine, sweat and saliva, do not need sample pretreatment, and are subjected to in-situ sample loading. The device provided by the invention is simple in structure and low-cost, the practicability is high, the detection time and economic cost are reduced greatly, and a technical support is provided for the rapid diagnosis and screening of critical illnesses.

The invention relates to the use of novel biomarkers and biomarker combinations having utility in the early determination of an individual's critical and/or life threatening response to illness and/or in predicting outcome of said illness. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention have utility in making the determination of an individual's critical and/or life threatening response to illness. In some embodiments, the biomarker and biomarker combinations are agnostic and are independent of the pre-identification and/or determination of the cause or nature of the illness. In some embodiments, the biomarkers and biomarker combinations can be utilized to select treatment and/or monitor the effectiveness of treatment interventions for an individual who has a critical illness.

The invention discloses an early warning system based on independent risk factor combinatory screening. In the system, an input module of the system is used for inputting personal basic information of a user to be detected, a selector module is used by the user to be detected, to select a blood test scheme to be carried out, a blood sampling device is used for collecting blood of the user to be detected, a blood tester is used for detecting type of the chosen blood test scheme for the collected blood of the user to be detected, a data processing module is used for receiving blood test results transmitted by the blood tester, comparing the blood test results with pre-stored reference data, and transmitting comparison results and conclusions to a results processing module after comparison is complete, and the results processing module is used for processing the received comparison results and conclusions, and transmitting the processed results to a results output module for displaying. The system and method carry out detection in a most convenient and feasible manner, attack rate of serious diseases and death rate are decreased, and the cost is low.

The invention belongs to the field of blood testing, and relates to a homogeneous phase multi-index fluorescence/chemiluminescence measuring method and application thereof. The method comprises the steps of: fixing a plurality of specificity recognition monoclonal antibodies on a polystyrene microsphere, and reacting with a plurality of labeled antibody cores modified by haptens after combining with carcinoembryonic antigens, cell keratin fragments 19, neuron specificity enolase and other multiple markers; reacting with horse radish peroxidase modified by corresponding hapten antibodies, alkaline phosphatase and quantum dots, and measuring a plurality of markers on the same instrument by combining with detections of chemiluminescence, fluorescence and the like. The method has the advantages of small blood serum consumption, rapid detection time, low diagnosis cost and simple operation, is suitable for detecting a plurality of popularized indexes simultaneously, and can provide auxiliary judgment basis for the early diagnosis of critical illnesses of tumor and the like.

The invention provides a fiber-free pre-digested high-energy medical formula food and a preparation method thereof. The formula food for special medical purposes comprises the following nutrients in grams per 1000ml: 64-92g of protein, 30-45g of fat, 200-280g of carbohydrate, 1.1-1.9g of vitamin, 14-21g of mineral and 560-690g of water. The fiber-free pre-digested high-energy high-fat high-proteinand low-carbohydrate formula food for special medical purposes is provided through reasonable raw material ratio and use; the formula does not contain dietary fiber and contains the six major nutrients required by a human body; pre-digested short peptide raw materials are adopted as protein sources; the fatty acid composition is optimized; and tea seed oil, yeast beta-glucan, glutamine, arginineand leucine which can enhance the body immunity are added at the same time. Therefore, comprehensive and balanced nutritional support can be provided for patients with limited fluid intake, critical illness, malnutrition and reduced immunity.

Described are medicaments and methods of treating or preventing metabolic bone diseases, such as Critical Illness Related Metabolic Bone Disease or of critical illness induced Osteopenia secondary to ICU Admission by sufficient autophagy inducing compound to inhibit or suppress critical illness enhanced osteoclastogenesis or increased osteoclast differentiation. The methods include administering of an autophagy activating compound to a mammal to: treat or prevent a bone degenerative disorder; slow bone deterioration; restore lost bone; maintain bone mass and/or bone quality or inhibit bone resorption in particularly by inhibiting or reducing a process by which osteoclasts break down bone and release the minerals resulting in a transfer of calcium from bone fluid to the blood. Also described are methods for administering the autophagy activating compound to treat a bone disorder of hyperresorption of bone and/or enhanced activation of osteoclasts.