806 results about "Saliva" patented technology

The invention discloses a buccal nicotine bag product and a preparation method thereof. The buccal nicotine bag product comprises a content and an outer package, the content is powdery and comprises a nicotine source and an acidic pH regulator; the outer package is a saliva permeable pouch and is used for packaging the content, so that the pH value of the buccal nicotine pouch product in pure water or saliva is smaller than 6.0. Optimizing the pH value to a weakly acidic range (pH lt; a specific buffer system and a slow-release carrier are combined to solve the problems of oral cavity stimulation, flavor limitation and high pH dependence in the using process of an existing nicotine bag, the palatability of the nicotine bag in the using process and the nicotine release efficiency in the mouth consumption process are improved, long-acting and stable nicotine delivery is achieved by controlling release kinetics, the production cost is reduced, and the nicotine bag is suitable for large-scale popularization and application. The consumption experience is improved.

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

The invention discloses an oral cancer early screening multi-parameter joint detection method and system, and relates to the technical field of data analysis, and the method comprises the steps: obtaining oral multi-dimensional data of a target user; wherein the oral cavity multi-dimensional data of the target user comprises oral cavity image data, oral cavity saliva miRNA data and oral cavity multi-frequency impedance data; presetting an oral cancerization suspicious classification lightweight model, preprocessing the oral multi-dimensional data of the target user, and generating an oral multi-modal feature vector and a preliminary screening oral state classification label of the target user; and deploying a Transform multi-mode oral canceration state grading and classification model, and carrying out conjoint analysis on the oral cavity multi-mode feature vector and the preliminary screening oral cavity state classification label of the target user to generate oral canceration state grading and classification of the target user. The oral canceration recognition method has the advantage that the oral canceration recognition accuracy is improved.

The invention belongs to the technical field of medical materials, and particularly relates to a tooth whitening composition and a preparation method thereof, the tooth whitening composition comprises the following components by weight: 5%-15% of hydrogen peroxide, 0.5%-1.5% of a gel matrix, 0.2%-1.0% of a thickener, 5%-10% of a humectant, 3%-8% of propylene glycol, 0.05%-0.2% of a chelating agent, 1%-3% of a sweetener, 0.1%-0.5% of sodium fluoride, and the balance of water. Aiming at the problems that an existing tooth whitening product is relatively low in pH value (most of 4.0-5.0), easy to irritate gingiva and sensitive in tooth manufacturing, and the existing tooth whitening product needs to be stored in a dark place at a low temperature and is short in whitening validity period, the pH value of the product is adjusted to 5.5-6.5, so that the product is close to oral saliva, the irritation can be reduced, the stability of the product can be ensured, the product is not easy to decompose, and the tooth whitening effect is good. Active ingredients are prevented from losing efficacy in advance, and the whitening validity period is prolonged.

The invention relates to the technical field of oral membranes, in particular to a multilayer oral membrane and a preparation method thereof. The invention provides an oral membrane composition, which comprises semeglutide and pharmaceutically acceptable auxiliary materials, and is characterized in that the composition is formed by combining a drug-containing biological adhesion layer and a backing layer, and the backing layer mainly comprises a membrane forming material, a solvent and a plasticizer; the drug-containing biological adhesion layer mainly comprises semeglutide, a film-forming material, an adhesive, a pH regulator, a flavoring agent and a solvent. By preparing the double-layer oral membrane, the semeglutide is administrated through the oral cavity, and after the insoluble or slowly eroded / dissolved backing layer (preventing saliva from dissolving the medicine) and the adhesive layer containing the main medicine are combined together, the one-way delivery of the main medicine can be realized; through experiments, it is accidentally found that when temperature-sensitive materials such as poloxamer are added to be combined with a conventional adhesive for use, the residence time of the medicine in the oral mucosa can be remarkably prolonged, the curative effect of the medicine is improved, and the main mechanism is that after the medicine is administered, in the oral temperature environment, after the medicine makes contact with mucus on the surface of the oral mucosa, the oral mucosa does not adhere to the oral mucosa. And after the entanglement and piling effects among poloxamer micelles are intensified to form gel, the gel and a conventional adhesive are cooperated to improve the adhesion between the oral membrane and the oral mucosa. Besides, the medicine can be removed at any time, blood sugar can be better controlled, T2DM complications can be better reduced, a more ideal taking mode is provided for weight loss patients, and a new administration mode is provided for reducing blood sugar and reducing weight. The prepared oral cavity membrane is small in size, light in weight, thin, convenient to apply, carry and transport, safe and environmentally friendly to use and capable of meeting the requirements of old people and travelers.

The invention discloses a combined lactobacillus salivarius D7-21 and application of the combined lactobacillus salivarius D7-21, the combined lactobacillus salivarius D7-21 is named as Ligilobacterium salivarius D7-21, and the preservation number of the combined lactobacillus salivarius D7-21 is CCTCC (China Center for Type Culture Collection) NO: M 20241905. The combined lactobacillus salivarius D7-21 has certain acid resistance and salt resistance, and can still grow in an MRS culture medium with the pH value of 3; the strain can grow in an MRS culture medium added with 4g / L cholate, and can grow in an MRS culture medium added with 8% by mass of NaCl; the additive and the feed for promoting the intestinal development of the chicks both contain the saliva combined lactobacillus D7-21, and have the effect of promoting the intestinal development of the chicks.

The invention discloses a preparation method of high-stability beta-glucan yoghourt. Mixing the sterilized fresh milk with a composite strain consisting of lactobacillus delbrueckii subsp. Bulgaricus, streptococcus salivarius subsp. Thermophilus, bifidobacterium animalis subsp. Lactis, plant lactobacillus, bifidobacterium breve, lactobacillus paracasei, lactobacillus helveticus, lactobacillus rhamnosus and bifidobacterium longum subsp. Longum, and fermenting; and adding beta-glucan into the fermented yoghourt to obtain the high-stability beta-glucan yoghourt. Before beta-glucan is added, the compound bacterial strain is added into the milk, protein in the milk can be gathered under the action of the compound bacterial strain to form a three-dimensional curd network, so that the flowability of a system is reduced, then glucan is added, and the glucan can be uniformly dispersed in curd gaps, so that the glucan is prevented from being excessively combined with the protein in the milk; the stability of a yoghourt system is improved.

The invention relates to the field of forensic medicine, and discloses a method and system for identifying smoking behaviors and application of the method and system. The construction method comprises the following steps: respectively obtaining saliva and excrement of a smoking object and a non-smoking object; performing metagenome sequencing to obtain original microbiome data; after processing the original microbiome data, extracting multi-omics feature information, including species information and gene function annotation information; based on a statistical analysis method, carrying out diversity analysis and screening microbial markers and functional genes significantly related to smoking behaviors; constructing a training set and a test set, and training a machine learning model and model evaluation by taking the microbial markers and / or the functional genes as input features; and performing smoking behavior identification on a target sample by using the model, and outputting a prediction result. The accuracy rate of model identification reaches 0.7966, the sensitivity is 0.8750, the specificity is 0.7037, and the method can be applied to health assessment and judicial expertise.

The invention relates to the technical field of microorganisms, in particular to space breeding combined lactobacillus salivarius ZK-88-S and application thereof. The combined lactobacillus salivarius ZK-88-S disclosed by the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC) on December 24, 2024, and the preservation number is CGMCC No.33181; the combined lactobacillus salivarius ZK-88-S can inhibit escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa, fusobacterium nucleatum, porphyromonas gingivalis, streptococcus mutans, streptococcus salivarius, streptococcus gordoni or actinomyces naessii, and can be applied to preparation of medicines, daily necessities or health-care foods for oral treatment and oral cleaning.

The invention relates to the technical field of biological medicine, in particular to a composition based on dendrobium nobile, a preparation method of the composition and application of the composition to preparation of soft capsules, buccal tablets and oral soluble film preparations, the composition takes dendrobium nobile extract as a main active ingredient, and can be matched with auxiliary materials such as excipients, disintegrating agents and film-forming agents to be optimized into different dosage forms. The soft capsule has a slow release effect, the buccal tablet is convenient to carry and take, and the oral soluble film can realize rapid oral mucosa absorption. The preparation method disclosed by the invention is stable in process and suitable for industrial production, and the obtained preparation has good bioavailability and stability, can be widely applied to the field of health-care foods or medicines, and is particularly suitable for enhancing immunity, resisting oxidation, moistening lung, promoting salivation and the like.

A test strip for detecting uric acid in saliva that meets the requirement for room-temperature preservation, a preparation and detection method therefor and the use thereof. The test strip for detecting uric acid in saliva comprises a uricase, a peroxidase, a vitamin C oxidase, a bilirubin oxidase, a color developing agent, and a protective film coated on the test strip for detecting uric acid in saliva. To meet the needs of a target population for long-term monitoring and real-time tracking of changes in their uric acid levels, by means of agent addition, the test strip for detecting uric acid in saliva has prolonged preservation time at room temperature, enables non-invasive, efficient and convenient monitoring of a health status at any time, and timely detection and treatment, allows intuitive visual identification of uric acid levels in saliva by a subject, and meets the needs of a subject for long-term preservation at room temperature.

Provided are a cat allergen polypeptide fragment and use thereof. Fel d1 is divided into a plurality of polypeptides of 10-20 amino acids, which are then co-expressed with VLPs proteins; subsequently, hyperimmune serum of Fel d1 is used for screening; and 2 Fel d1 polypeptides with relatively good immunogenicity are successfully screened. The 2 polypeptides are used for co-expression with VLPs and then formulated into a vaccine to immunize a cat. The secretion amount of Fel d1 in the cat saliva is detected, and the secretion amount of Fel d1 can be reduced by 80% or more. The described polypeptides effectively reduce the secretion amount of the Fel d1 protein in the cat saliva, and reduce the spread of Fel / d1 in the air.

The utility model discloses an oral cavity product, which comprises an oral soluble film and a support layer, the support layer has water-insoluble property, the support layer is arranged on at least one surface of the oral soluble film or embedded in the oral soluble film, the support layer is provided with at least one channel, and the channel is used for saliva to pass through the support layer. The supporting layer can play a supporting role, the probability that the oral dissolving film shrinks and even directly disintegrates in the attaching process is reduced, a user can smoothly attach the oral dissolving film to the position where the oral dissolving film needs to be placed when using an oral product, the use cost of the oral product is reduced, the supporting layer can keep the shape for a long time, and the service life of the oral dissolving film is prolonged. The oral product can be moved or withdrawn from the oral cavity at will according to requirements, so that the usability of the oral product is improved.

The present application relates to use of Ligilactobacillus salivarius in preparing a drug for preventing and / or treating diseases associated with overweight and / or obesity . The strain can inhibit the weight growth of a high-fat diet-induced obesity model mouse, reduce the blood lipid level of the high-fat diet-induced obesity model mouse, improve the liver injury index of the high-fat diet-induced obesity model mouse, reduce the area of white adipose cells of the high-fat diet-induced obesity model mouse, improve the colon GLP-1 level of the high-fat diet-induced obesity model mouse, improve the intestinal flora imbalance of the high-fat diet-induced obesity model mouse, and improve the liver glycolipid metabolism of the high-fat diet-induced obesity model mouse; and reduce the waist circumference, hip circumference, body fat mass, BMI, and weight of overweight and overweight and / or obesity volunteers, and maintain the muscle content, promoting overweight and overweight and / or obesity people to carry out safe, effective, and sustainable weight management.

Disclosed in the present invention is a probiotic. The probiotic comprises Parabacteroides distasonis with the microbial deposit number of CCTCC NO: M20222033, Limosilactobacillus fermentum with the microbial deposit number of CCTCC NO: M2023352, Lactobacillus salivarius with the microbial deposit number of CCTCC NO: M2023348, Enterococcus avium with the microbial deposit number of CCTCC NO: M2023350, and Bifidobacterium bifidum with the microbial deposit number of CCTCC NO: M2023349. The probiotic has good safety, has antioxidant activity, can inhibit pathogenic bacteria, can alleviate colon injury, can inhibit inflammation, and can alleviate diarrhea caused by chemotherapeutic drugs.

The invention relates to the technical field of prebiotics preparation, and discloses a preparation method of prebiotics applied to reproduced areca catechu, and the preparation method comprises the following steps: carrying out enzyme catalysis reaction on sucrose by adopting fructosyl transferase to prepare fructo-oligosaccharide; according to the method, beta-galactosidase is adopted to carry out enzyme catalysis reaction on lactose, so that galactooligosaccharide is prepared; respectively carrying out decoloration, ion exchange, nanofiltration concentration and spray drying on the candy oligosaccharide and the galactooligosaccharide to obtain powder; the method comprises the following steps: mixing fructo-oligosaccharide powder and galactooligosaccharide powder according to a ratio, and uniformly distributing the mixture in a reproduced areca-nut matrix by adopting a spray-drying blending or low-temperature vacuum mixing mode to form a functional reproduced areca-nut product; according to the invention, low-temperature drying is carried out on the product after blending or vacuum mixing, so that the prebiotic areca nuts are released along with saliva in the chewing process, and are selectively utilized by bifidobacteria and lactic acid bacteria after entering the stomach and intestine, thereby achieving the purposes of regulating intestinal flora and improving the health-care function.

The invention provides a combined lactobacillus salivarius YS-UR90 and a preparation method of the combined lactobacillus salivarius YS-UR90. The saliva combined lactobacillus provided by the invention can secrete protease and glycosidase, and the HCT and FLS gene expression levels of the saliva combined lactobacillus are high, so that the saliva combined lactobacillus can promote phenolic acid active ingredients to generate biotransformation during fermentation, and the proportion of chlorogenic acid and the like in fermentation liquor is increased. For example, marine fish oligopeptide and casein phosphopeptides are used as a composite nitrogen source, dandelion powder is used as a functional substrate, and a composite fermentation product obtained through fermentation of saliva and lactobacillus has the effect of promoting uric acid excretion and has a certain protection effect on kidney injury. The compound fermentation product has the effect of improving hyperuricemia mainly by inhibiting XOD activity, increasing serum urea nitrogen level, improving defect expression of uric acid synthesis gene HPRT1, inhibiting expression of uric acid reabsorption URAT1 and GLUT9 genes and improving expression of excretion genes OAT1 and ABCG2.

The invention belongs to the technical field of electrochemical detection, and discloses an anti-pollution electrochemical saliva sensor based on fluorinated side chain polypeptide as well as a preparation method and application of the anti-pollution electrochemical saliva sensor. The fluorinated side chain polypeptide disclosed by the invention not only has excellent hydrophilicity, can form a dense hydration layer with water molecules to repel pollutants, but also has low surface energy, and the interaction between the pollutants and an interface is remarkably reduced. Through the synergistic effect, the fluorinated side chain polypeptide has better anti-pollution performance compared with traditional zwitterionic polypeptide. The anti-pollution electrochemical sensor constructed on the basis of the fluorinated side chain polypeptide can be used for directly detecting CA15-3 in saliva, the saliva does not need to be pretreated, and the detection accuracy can be comparable with that of a commercial ELISA (Enzyme-Linked Immunosorbent Assay) method.

The invention provides an application of streptococcus salivarius in fatty liver, in particular to an application of streptococcus salivarius in preparation of a product, and the product is used for at least one of the following applications: (a) losing weight or reducing body fat; (b) improving the glucose tolerance of the patient; (c) increasing the sensitivity of the patient to insulin; (d) treating, relieving and preventing liver injury; (e) treating, relieving and preventing non-alcoholic steatohepatitis; (f) fat deposition caused by high-fat and high-cholesterol diet is reduced; (g) reducing blood fat; and / or (h) improving the level of at least one of the following indexes in the liver of the mammal: total cholesterol, triglyceride, low density lipoprotein-cholesterol and free fatty acid.

The invention discloses a tooth whitening gel and a preparation method thereof. The tooth whitening gel comprises the following components in percentage by mass: 5%-25% of a film-forming agent, 0.1%-15% of peroxide, 0.1%-15% of a regulator and 45%-94.8% of a volatile solvent, the film-forming agent is modified ethyl cellulose, and the preparation method comprises the step of treating ethyl cellulose by adopting one or more of irradiation, illumination, oxidation, heating, mechanical pulverization and grinding to obtain the modified ethyl cellulose. The preparation method of the tooth whitening gel comprises the step of uniformly mixing the raw materials including the film-forming agent, the peroxide, the regulator and the volatile solvent to obtain the tooth whitening gel. The tooth whitening gel provided by the invention can be ensured not to be dissolved by saliva after being smeared on teeth, and can be ensured to be completely removed when being removed.

A spectral sensing device and associated methods for enhanced diagnostic capabilities across medical fields are disclosed. The device incorporates multispectral, hyperspectral, and photoplethysmography technologies to analyze biological features including tongue, oral cavity, saliva, teeth, and other tissues. The system transforms any standard RGB camera into a multispectral imaging device by training machine learning models to associate RGB values with spectral values inside and outside the visible spectrum using measurements from a single pixel detector spectroradiometer. A multimodal neural network with separate processing branches analyzes spectral images, non-spectral images, and tabular data to predict microbiome composition. The system generates health risk assessments by comparing predicted microbial abundances to thresholds associated with various medical conditions. Near-infrared sensing enables blood flow monitoring, subcutaneous imaging, and assessment of physiological parameters. Convolutional neural networks enable spectral reconstruction without requiring the physical device, while supporting continuous monitoring in various form factors.

The invention belongs to the technical field of biomedical treatment and biological fermentation, discloses a metagen composition for effectively inhibiting oral dental caries and application thereof, and aims to solve the problems of great side effect, weak effect and unknown mechanism of the existing dental caries prevention and treatment means. The composition is prepared by mixing a metagen 1 which is prepared by fermenting lactobacillus salivarius Postbio-YY with a metagen 2 which is prepared by fermenting lactococcus lactis Postbio-F3 and lactobacillus paracasei Postbio-P6 step by step. In the preparation process, the active ingredients are reserved by accurately controlling the fermentation pH, time and pasteurization parameters. The composition can be prepared into multiple dosage forms such as toothpaste and the like, can remarkably inhibit the growth of streptococcus mutans and destroy the thallus structure, inhibits biofilm and exopolysaccharide synthesis by down-regulating fimI, wcaJ and wcae genes, is safe and free of side effects, and provides an efficient scheme for decayed tooth prevention and treatment.

Compositions comprising 5. salivarius strain SALI-10 and / or salivarius 10 peptide are taught. Also taught are methods of treating bacterial infections comprising administering a pharmaceutically acceptable amount of the composition to the patient with a bacterial infection caused by a pathogen from, for example, multi-drug resistant (MDR) Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus dysagalactiae, vancomycin-resistant Enterococcus faecium, Porphyromonas gingivalis, Tannerella forsythia, and MDR Enterococcus faecalis.

The invention relates to a nicotine buccal bag with a content fixing cavity and a preparation method of the nicotine buccal bag. The nicotine buccal bag comprises a bag body, contents and a content fixing wall, the bag body is a saliva permeable bag; the content comprises a nicotine source and a functional capsule; the functional capsule comprises a shell and an inner core; the shell is saliva impermeable and is suitable for being destroyed by external force; the inner core comprises at least one of a pH regulator solution and a flavor provider solution; the content fixing wall and the bag body are relatively fixed, and a closed content fixing cavity is formed by the content fixing wall and the bag body; and a nicotine source and a functional capsule are accommodated in the content fixing cavity. The invention also relates to a preparation method of the nicotine buccal bag. The fixing cavity enables the functional capsule to have a certain and predictable position, and storage and use are convenient.

The invention belongs to the technical field of microorganisms, and particularly relates to combined lactobacillus salivarius and application thereof in female genital tract health. The preservation number of the strain is CCTCC NO: M20231719, and the strain has good bacteriostatic ability and dendritic cell (DC) maturation / activation stimulation ability, has no potential safety problem, can regulate vaginal micro-ecological balance, prevent infection caused by exogenous bacteria, effectively improve tumor immunosuppression microenvironment, and has good application prospects. And the method has very important significance on prevention / treatment of vaginal dysbacteriosis patients, gynecological tumors and precancerous lesions thereof.

The invention discloses a cascade catalytic enzyme MOF-919-GOx as well as a preparation method and application thereof, and relates to the technical field of nano-enzymes. According to the invention, MOF-919-GOx is synthesized by a glutaraldehyde loading method, and detection shows that the loading capacity of GOx in MOF-919 is 372.20 [mu] g / mg; when 2 mg / mL of MOF-919-GOx and 25 mM of glucose are added, the pH value of the environment can be reduced, hydroxyl radicals can be generated, and efficient peroxidase-like activity is achieved. The cascade catalytic enzyme MOF-919-GOx has a concentration-dependent inhibition effect on suspended porphyromonas gingivalis and staphylococcus aureus, and the concentration-dependent inhibition effect on the suspended porphyromonas gingivalis and staphylococcus aureus is achieved. When the concentration of the MOF-919-GOx is 0.25 mg / mL, the MOF-919-GOx can generate a remarkable removal effect on a biological membrane in a dog oral cavity artificial saliva environment, can be used for developing a dog oral cavity antibacterial material, and has application potential in the veterinary clinical field.

The invention relates to the technical field of marine microorganisms, in particular to application of combined lactobacillus salivarius in preparation of products for improving metabolism of alcohol and uric acid, the combined lactobacillus salivarius NHNK-603 is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 2024416. Experiments show; the NHNK-603 has the effects of inhibiting the growth of klebsiella pneumoniae, inhibiting the production of alcohol, agglutinating the klebsiella pneumoniae, inhibiting the virulence gene of the klebsiella pneumoniae, promoting alcohol metabolism, reducing alcohol damage, tolerating alcohol, degrading uric acid, inhibiting the activity of xanthine oxidase, promoting uric acid excretion, promoting the proliferation of Alistipes indinctus and synthesizing hippuric acid; the thallus biofilm increases the function of colonization on mucoprotein and intestinal epithelial cells, and can be applied to preparation of products for improving metabolism of alcohol and uric acid.

The invention relates to the technical field of nursing materials, and discloses an oral and maxillofacial nursing drainage apparatus, the oral and maxillofacial nursing drainage apparatus comprises a main pipe, an auxiliary pipe and a clamping sleeve which are integrally formed, the main pipe is provided with a drainage assembly, the drainage assembly comprises two sets of conical pipes, and the large ends of the two sets of conical pipes are fixedly connected with the two ends of the main pipe respectively. According to the oral and maxillofacial nursing drainage apparatus, by arranging the drainage assembly, when the drainage head is placed on a wound surface, a solid-liquid mixture can be drained, when the drainage cylinder is placed on the wound surface, the drainage cylinder is matched with the drainage hole to drain a liquid drainage object, natural negative pressure drainage force is generated through the height difference, and the drainage object enters the drainage collection bin through the hose, the conical pipe, the main pipe and the bent pipe; the sealing dressing is matched to improve the sealing performance, the auxiliary tube and the threaded locking valve are matched to facilitate drainage object removal, wound surface liquid accumulation, hematocele or necrotic tissue can be sucked out actively under the stable negative pressure, saliva pollution is isolated through the sealing design, and the drainage amount is measured through scale marks.

The invention relates to genetic engineering combined lactobacillus salivarius and application of the genetic engineering combined lactobacillus salivarius. The strain is classified and named as combined lactobacillus salivarius CTMT2, and the preservation number of the strain is CCTCC (China Center for Type Culture Collection) M 2025547. After an NIAAA model is injected into the stomach of an alcoholic liver mouse, the acetaldehyde level of the liver of the mouse is obviously reduced, and the alcoholic fatty liver symptom of the mouse is obviously relieved; after long-term intragastric administration of a high-glucose and high-fat modeling mouse, the acetaldehyde level in excrement of the mouse can be obviously reduced, the progress of liver fibrosis is improved, and good application prospects are achieved.

The utility model belongs to the technical field of auxiliary rehabilitation instruments, and particularly discloses a tongue muscle training device. The tongue muscle trainer comprises a tongue sleeve, a breather pipe and an air pump, and the air pump and the breather pipe are connected through a connecting sleeve; a first groove is formed in the top of a shell of the air pump, and a first boss with a first vent hole is arranged on one side of the first groove; a partition plate is arranged in the middle of the connecting sleeve, and a second boss with a second vent hole is arranged on one side of the partition plate. Through the arrangement of the second boss, saliva flowing down through the ventilation pipe can be prevented from flowing into the top of the shell through the second ventilation hole; the first boss can prevent saliva from flowing into the shell through the first vent hole; the first vent hole and the second vent hole are arranged in a staggered manner, so that saliva flowing down through the second vent hole can be further prevented from directly falling into the shell through the first vent hole.