1862 results about "Saliva" patented technology

The invention discloses an intestinal flora marker related to Parkinson's syndrome and application of the intestinal flora marker. The invention discloses an intestinal flora marker, which comprises one or a combination of more of bacteroides faecalis, bacteroides vulgaris, bacteroides thetaotamicrobe, ruminococcus ruminococcus and lactobacillus salivarius, and is characterized in that the intestinal flora marker comprises one or a combination of more of bacteroides faecalis, bacteroides vulgaris, bacteroides thetaotamicrobe, ruminococcus ruminococcus and lactobacillus salivarius, and the intestinal flora marker comprises one or a combination of more of the bacteroides vulgaris, the bacteroides vulgaris, the bacteroides thetaotamicrobe, the ruminococcus ruminococcus and the lactobacillus salivarius. The intestinal flora marker is used as a detection marker to be applied to diagnosis of Parkinson's syndrome patients, and is completely noninvasive and high in accuracy.

The invention relates to an oral mucosa repairing medicine and a preparation method thereof, and belongs to the technical field of medicines, the medicine comprises barnacle peptide, salivary lactobacillus, resveratrol, a biphasic adhesion matrix, hydroxyapatite, vitamin B family and other components. The preparation method comprises the following steps: sequentially carrying out enzymolysis on barnacle gooseneck by pepsin and lumbrukinase to obtain barnacle peptide. The double-phase adhesion matrix comprises a water-phase matrix, an oil-phase matrix and lecithin; the water-phase matrix contains a chondroitin sulfate-chitosan quaternary ammonium salt compound, sodium alginate and other components; the oil-phase matrix comprises sesame oil, beeswax, a polylactic acid-glycolic acid copolymer and the like. According to the invention, barnacle peptide and salivary lactobacillus are prepared by adopting a special method and are matched with resveratrol for use, so that multi-target and multi-path promotion of oral mucosa repair can be realized; the chondroitin sulfate-chitosan quaternary ammonium salt compound is prepared through electrostatic and physical embedding, the chondroitin sulfate-chitosan quaternary ammonium salt compound is matched with other components to prepare the biphasic adhesion matrix, the biocompatibility is good, the adhesion is high, and the action time of a sustained-release drug is well prolonged.

The invention discloses a buccal nicotine bag product and a preparation method thereof. The buccal nicotine bag product comprises a content and an outer package, the content is powdery and comprises a nicotine source and an acidic pH regulator; the outer package is a saliva permeable pouch and is used for packaging the content, so that the pH value of the buccal nicotine pouch product in pure water or saliva is smaller than 6.0. Optimizing the pH value to a weakly acidic range (pH lt; a specific buffer system and a slow-release carrier are combined to solve the problems of oral cavity stimulation, flavor limitation and high pH dependence in the using process of an existing nicotine bag, the palatability of the nicotine bag in the using process and the nicotine release efficiency in the mouth consumption process are improved, long-acting and stable nicotine delivery is achieved by controlling release kinetics, the production cost is reduced, and the nicotine bag is suitable for large-scale popularization and application. The consumption experience is improved.

The invention belongs to the technical field of microorganisms, and provides streptococcus salivarius subsp. Thermophilus HX-ST36, and the preservation number of the streptococcus salivarius subsp. Thermophilus HX-ST36 is CGMCC NO.32955. The streptococcus salivarius subsp. Thermophilus provided by the invention can be used for fermenting astragalus membranaceus-angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrheal model mouse, a fermentation product can remarkably inhibit the writhing reaction, and the effects of relieving dysmenorrheal and enriching blood can be achieved by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the content of hemoglobin (HGB). The dampness clearing effect of the fermentation product is verified by improving the heavy physical sign of moisture through crowd experiments. The invention also provides a preparation method of the probiotic preparation and the probiotic fermentation product. The preparation methods of the probiotic preparation and the probiotic fermentation product are simple, and large-scale production can be realized.

The invention relates to the technical field of biological medicine, in particular to cat allergen fusion protein, an mRNA immune preparation and application of the cat allergen fusion protein and the mRNA immune preparation. The amino acid sequence of the cat allergen fusion protein disclosed by the invention is as shown in SEQ ID NO.11. The cat allergen fusion protein provided by the invention is a fusion protein obtained by fusing key segments with strong sensitization of Fel d2 and Fel d4 proteins with Fel d1 full-length protein, the fusion protein can simultaneously cover main sensitization epitopes of Fel d1, Fel d2 and Fel d4, and the sensitization effect of cat allergens can be more comprehensively blocked. According to the cat allergen fusion protein provided by the invention, an mRNA immune preparation can be rapidly designed and synthesized, the expression of the cat allergen fusion protein can be accurately controlled in poultry bodies, the immunoreaction is more durable, and the prepared IgY antibody can effectively block allergic protein in cat oral saliva.

The present invention is related to a dental device (1) intended to cover at least part of a teeth (2) and / or at least part of gums (3) or other surfaces of a mouth for repositioning or retaining said teeth (2) and optionally said gums (3) or other surfaces of the mouth, said dental device (1) comprising a channel (7) provided in a main body (31; 40, 42) of the dental device (1) and having at least one opening (4, 5) to the exterior. The present invention is also related to a method of manufacturing said dental device (1) by additive manufacturing and to methods for circulating a substance and / or saliva and oxygen through the dental device (1) in view of releasing said substance and / or saliva and oxygen inside the mouth.

The present invention relates to the technical field of microorganisms. Provided are a probiotic composition and a use thereof in the preparation of a product for preventing and / or treating anti-tumor treatment-related diarrhea and other health conditions. Active ingredients of the probiotic composition comprise Bifidobacterium bifidum, Enterococcus avium, Ligilactobacillus salivarius, Limosilactobacillus fermentum, and Parabacteroides distasonis. The probiotic composition has good safety, auto-aggregation capacity, antioxidant capacity, short-chain fatty acid production capacity, in-vitro cell adhesion capacity, capacity to inhibit multiple pathogenic bacteria, and capacity to treat anti-tumor treatment-related diarrhea, etc.

A oral suction device that incorporates a foldable suction body, a bite block and a suction adapter that is utilized to block the throat cavity. The body draws water, saliva and debris from about a gap along its outer perimeter. The suction body resides in a vertical position in the patient's mouth and is able to expand to allow the transport of large pieces of debris without coming apart. There is a fishtail section of the suction body that anchors it between the teeth and the inner cheek so as to allow the remained of the suction body to block the throat hole.

The invention belongs to the field of molecular biological detection, and provides a joint detection composition which is mainly used for detecting related pathogens by using a multiple fluorescent PCR (Polymerase Chain Reaction) analysis method. Therefore, at least four of staphylococcus aureus, staphylococcus capitis, bacteroides fragilis, streptococcus agalactiae, streptococcus salivarius and staphylococcus hominis are detected and distinguished in a single-tube reaction system at the same time. Meanwhile, the detection sensitivity of the composition is higher and reaches 200 copies / mL, and the detection is more accurate.

The invention discloses an intestinal flora marker related to juvenile depression, a product and application of the intestinal flora marker. The intestinal flora marker is prepared from any one or more of prokaryotic streptococcus parahaemolyticus, streptococcus salivarius, Alistipep and Lacnospiraceae, and the intestinal flora marker is prepared from any one or more of prokaryotic streptococcus parahaemolyticus, streptococcus salivarius, Alistipep and Lacnospiraceae, and the intestinal flora marker is prepared from any one or more of the prokaryotic streptococcus parahaemolyticus, the streptococcus salivarius, the Alistipep and the Lacnospiraceae, the prokaryotic streptococcus parahaemolyticus, the Streptococcus salivarius, the Alistipep and the Lacnospiraceae. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal flora marker. The invention provides a product for diagnosing juvenile depression and a computer program product related to the juvenile depression. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of depression of teenagers, and provides a new tool for clinical diagnosis.

The invention discloses an application of a streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet in preparation of a product for treating adenoid body inflammation. The preservation number of the streptococcus salivarius subsp. Thermophilus Biohalo 23 is DSM34540; the streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet disclosed by the invention can be used for relieving the disease symptom of adenoid body inflammation and reducing the incidence rate of adenoid body inflammation, so that the streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet disclosed by the invention has a remarkable curative effect on adenoid body inflammation, and particularly, through clinical tests, the streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet has a remarkable curative effect on adenoid body inflammation. The streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet disclosed by the invention can be used for remarkably improving symptoms such as tachypnea, mouth breathing, snoring, cough, nasal obstruction, hearing loss and the like, and also can be used for reducing the incidence rate of adenoid body inflammation, so that the streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet disclosed by the invention can be used for treating the adenoid body inflammation.

The invention belongs to the technical field of microorganisms. The invention relates to a probiotic composition and application thereof in preparation of products for preventing and / or treating health conditions such as anti-tumor treatment related diarrhea. The probiotic composition comprises the following active ingredients: bifidobacterium bifidum, enterococcus faecalis, lactobacillus salivarius, lactobacillus fermentum mucus and parabacteroides didysonii. The probiotic composition has good safety, self-agglutination capability, oxidation resistance, short-chain fatty acid production capability, in-vitro cell adhesion capability, capability of inhibiting a plurality of pathogenic bacteria, capability of treating anti-tumor treatment related diarrhea and the like.

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

The invention discloses an oral cancer early screening multi-parameter joint detection method and system, and relates to the technical field of data analysis, and the method comprises the steps: obtaining oral multi-dimensional data of a target user; wherein the oral cavity multi-dimensional data of the target user comprises oral cavity image data, oral cavity saliva miRNA data and oral cavity multi-frequency impedance data; presetting an oral cancerization suspicious classification lightweight model, preprocessing the oral multi-dimensional data of the target user, and generating an oral multi-modal feature vector and a preliminary screening oral state classification label of the target user; and deploying a Transform multi-mode oral canceration state grading and classification model, and carrying out conjoint analysis on the oral cavity multi-mode feature vector and the preliminary screening oral cavity state classification label of the target user to generate oral canceration state grading and classification of the target user. The oral canceration recognition method has the advantage that the oral canceration recognition accuracy is improved.

The utility model relates to the technical field of medical instruments, in particular to an oral cavity supporting intelligent saliva aspirator which comprises a first supporting frame, one end of the first supporting frame is fixedly connected with a fixing assembly, one side of the first supporting frame is fixedly connected with a first saliva aspirating assembly, and the upper surface of the first supporting frame is fixedly connected with an adjusting assembly. One end of the first saliva suction assembly is fixedly connected with a control assembly, one end of the control assembly is fixedly connected with a second saliva suction assembly, and the other end of the control assembly is fixedly connected with a connecting assembly. Through the arrangement of the second supporting frame, the supporting column, the threaded rod and the threaded sleeve shell, during use, the threaded sleeve shell is held and rotated to drive the threaded rod to rotate and ascend and descend in the threaded sleeve shell and the supporting column, so that the distance between the first supporting frame and the second supporting frame is adjusted; therefore, the effects of adapting to more people with different mouth sizes and freely adjusting the opening and closing amplitude of the oral cavity according to treatment requirements are achieved.

The invention relates to the technical field of saliva flow rate detection, and discloses a saliva flow rate detection device which comprises a main body part, a filter element, a sampling head and a sensor, the main body part is provided with a first end and a first channel, the first channel penetrates through the first end to form a first opening, the filter element is arranged in the first channel, and the sampling head is provided with a second channel; the second channel penetrates through the sampling head, the sampling head is arranged at the first end, the second channel is communicated with the first channel, and the sensor is arranged on the main body part and is suitable for detecting whether saliva infiltrates the to-be-detected area or not. The saliva flow rate measuring device has the beneficial effect that the saliva flow rate measuring precision and efficiency are improved.

The invention provides a hydrogel microneedle patch for treating oral ulcer and a preparation method, and belongs to the technical field of biomedical engineering. The technical problems that in the traditional oral ulcer administration process, medicine is difficult to retain at the focus for a long time, is easily scoured by saliva and is influenced by tongue and cheek movement are solved. According to the technical scheme, the method comprises the following steps: 1) designing and preparing a microneedle patch mold; (2) synthesizing drug-loaded polydopamine nano particles; (3) preparing a microneedle patch; and 4) evaluating the performance of the microneedle patch. The invention has the following beneficial effects: on one hand, the combination of the drug-loaded nanoparticles and the hydrogel microneedle array can reduce the dosage through drug sustained release; and on the other hand, the problems of high drug instability, low targeting property, poor bioavailability and hindering treatment effect are effectively solved, and the preparation can be widely applied to the fields of drug sustained release, wound healing, tissue engineering and the like.

The invention discloses streptococcus salivarius subsp. Thermophilus JMCC0040 for preparing Greek yogurt and application of the streptococcus salivarius subsp. Thermophilus JMCC0040, and belongs to the technical field of microbial engineering. The streptococcus salivarius subsp. Thermophilus JMCC0040 strain is preserved in the China General Microbiological Culture Collection Center, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, the preservation date is February 1, 2024, the preservation number is CGMCC NO.29835, and the Latin name is Streptococcus salivarius subsp. Thermophilus. The streptococcus salivarius subsp. Thermophilus JMCC0040 strain is named as Streptococcus salivarius subsp. Thermophilus. The streptococcus salivarius subsp. Thermophilus JMCC0040 for preparing the Greek yogurt, provided by the invention, has the advantages of good fermentation characteristic, high fermentation speed, weak post-acidity, low pink feeling of a fermented dairy product, high smoothness and good texture, and is suitable for preparing the Greek yogurt with higher requirements on fermentation strains.

Disclosed in the present invention is a Ligilactobacillus salivarius strain VB330, which is preserved in China General Microbiological Culture Collection Center on September 08, 2023, the accession number thereof being CGMCC No. 28406. The Ligilactobacillus salivarius VB330 disclosed by the present invention has broad-spectrum antibacterial characteristics, and has huge application prospects in the preparation of probiotic formulations, oral care products and drugs.

The present invention relates to an apparatus (1) and a method for manufacturing a pouched product (201) for oral use. The present invention further relates to a pouched product (201) for oral use. The apparatus comprises a supplying unit (3) for supplying a filling material (5), a holding unit (7) for holding a piece (9) of tubular web of a saliva-permeable packaging material, the piece of tubular web having a predefinable length when provided to the holding unit, a transverse sealing unit (11) for providing the piece of tubular web with transverse seals (13) thereby forming a pouched product, and a separation unit (15) for separating the pouched product from a subsequent pouched product (201′) in or at the transverse seals. The holding unit comprises guiding provisions (17) for guiding the filling material from the supplying unit to be supplied into the piece of tubular web at an end (19) of the holding unit, wherein a length of the holding unit (Lh) is at least 35 cm.

The present disclosure provides for devices and systems for detecting biological agents (e.g., virus such as coronavirus) using nanotriangles having a capture agent. The present disclosure also includes methods of detecting the presence and amount of the biological agent in a sample, such as saliva, blood, or urine. In addition, the present disclosure provides for a detecting module and a method of making the detecting module, where the detecting module includes the nanotriangles having the capture agent bonded thereto that has an affinity for the biological agent.

The invention belongs to the technical field of medical materials, and particularly relates to a tooth whitening composition and a preparation method thereof, the tooth whitening composition comprises the following components by weight: 5%-15% of hydrogen peroxide, 0.5%-1.5% of a gel matrix, 0.2%-1.0% of a thickener, 5%-10% of a humectant, 3%-8% of propylene glycol, 0.05%-0.2% of a chelating agent, 1%-3% of a sweetener, 0.1%-0.5% of sodium fluoride, and the balance of water. Aiming at the problems that an existing tooth whitening product is relatively low in pH value (most of 4.0-5.0), easy to irritate gingiva and sensitive in tooth manufacturing, and the existing tooth whitening product needs to be stored in a dark place at a low temperature and is short in whitening validity period, the pH value of the product is adjusted to 5.5-6.5, so that the product is close to oral saliva, the irritation can be reduced, the stability of the product can be ensured, the product is not easy to decompose, and the tooth whitening effect is good. Active ingredients are prevented from losing efficacy in advance, and the whitening validity period is prolonged.

The invention relates to the technical field of oral membranes, in particular to a multilayer oral membrane and a preparation method thereof. The invention provides an oral membrane composition, which comprises semeglutide and pharmaceutically acceptable auxiliary materials, and is characterized in that the composition is formed by combining a drug-containing biological adhesion layer and a backing layer, and the backing layer mainly comprises a membrane forming material, a solvent and a plasticizer; the drug-containing biological adhesion layer mainly comprises semeglutide, a film-forming material, an adhesive, a pH regulator, a flavoring agent and a solvent. By preparing the double-layer oral membrane, the semeglutide is administrated through the oral cavity, and after the insoluble or slowly eroded / dissolved backing layer (preventing saliva from dissolving the medicine) and the adhesive layer containing the main medicine are combined together, the one-way delivery of the main medicine can be realized; through experiments, it is accidentally found that when temperature-sensitive materials such as poloxamer are added to be combined with a conventional adhesive for use, the residence time of the medicine in the oral mucosa can be remarkably prolonged, the curative effect of the medicine is improved, and the main mechanism is that after the medicine is administered, in the oral temperature environment, after the medicine makes contact with mucus on the surface of the oral mucosa, the oral mucosa does not adhere to the oral mucosa. And after the entanglement and piling effects among poloxamer micelles are intensified to form gel, the gel and a conventional adhesive are cooperated to improve the adhesion between the oral membrane and the oral mucosa. Besides, the medicine can be removed at any time, blood sugar can be better controlled, T2DM complications can be better reduced, a more ideal taking mode is provided for weight loss patients, and a new administration mode is provided for reducing blood sugar and reducing weight. The prepared oral cavity membrane is small in size, light in weight, thin, convenient to apply, carry and transport, safe and environmentally friendly to use and capable of meeting the requirements of old people and travelers.

The invention discloses a ginseng oral soluble film and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. The ginseng oral soluble film prepared by the invention comprises a ginseng extract, a ginseng extractum, a filling agent, an adhesive, a plasticizing forming agent and a seasoning component, is a novel dosage form, is convenient to take and carry, and provides a novel ginseng product and a consumption mode; meanwhile, when the oral liquid is placed on the tongue, the oral liquid can be rapidly dissolved and release drugs in saliva without drinking water, the compliance of a user can be greatly improved, and the preparation process has low requirements on preparation instruments, is low in cost, is beneficial to large-scale industrial production, does not generate or generates little three wastes, meets the requirements of sustainable development, and has a good application prospect.

The invention discloses a combined lactobacillus salivarius D7-21 and application of the combined lactobacillus salivarius D7-21, the combined lactobacillus salivarius D7-21 is named as Ligilobacterium salivarius D7-21, and the preservation number of the combined lactobacillus salivarius D7-21 is CCTCC (China Center for Type Culture Collection) NO: M 20241905. The combined lactobacillus salivarius D7-21 has certain acid resistance and salt resistance, and can still grow in an MRS culture medium with the pH value of 3; the strain can grow in an MRS culture medium added with 4g / L cholate, and can grow in an MRS culture medium added with 8% by mass of NaCl; the additive and the feed for promoting the intestinal development of the chicks both contain the saliva combined lactobacillus D7-21, and have the effect of promoting the intestinal development of the chicks.

The invention discloses a preparation method of high-stability beta-glucan yoghourt. Mixing the sterilized fresh milk with a composite strain consisting of lactobacillus delbrueckii subsp. Bulgaricus, streptococcus salivarius subsp. Thermophilus, bifidobacterium animalis subsp. Lactis, plant lactobacillus, bifidobacterium breve, lactobacillus paracasei, lactobacillus helveticus, lactobacillus rhamnosus and bifidobacterium longum subsp. Longum, and fermenting; and adding beta-glucan into the fermented yoghourt to obtain the high-stability beta-glucan yoghourt. Before beta-glucan is added, the compound bacterial strain is added into the milk, protein in the milk can be gathered under the action of the compound bacterial strain to form a three-dimensional curd network, so that the flowability of a system is reduced, then glucan is added, and the glucan can be uniformly dispersed in curd gaps, so that the glucan is prevented from being excessively combined with the protein in the milk; the stability of a yoghourt system is improved.

The invention discloses combined lactobacillus salivarius CCFM1327 capable of inhibiting foaming of macrophages and relieving periodontitis, and belongs to the technical field of microorganisms. According to the invention, the strain of combined lactobacillus salivarius CCFM1327 is obtained, and the combined lactobacillus salivarius has the effects of inhibiting foaming of macrophages and relieving periodontitis, which are specifically reflected in that the combined lactobacillus salivarius can inhibit foaming of RAW264.7 cells caused by ox-LDL; the growth of porphyromonas gingivalis can be effectively inhibited; the periodontal probing and diagnosing depth of the periodontitis rats can be obviously reduced; the number of pathogenic bacteria in the oral cavity of the periodontitis rat is reduced; the level of an inflammatory factor IL-17A in serum is reduced; alveolar bone loss of rats suffering from periodontitis is reduced; and the number of alveolar bone osteoclasts is reduced.

The invention relates to the field of forensic medicine, and discloses a method and system for identifying smoking behaviors and application of the method and system. The construction method comprises the following steps: respectively obtaining saliva and excrement of a smoking object and a non-smoking object; performing metagenome sequencing to obtain original microbiome data; after processing the original microbiome data, extracting multi-omics feature information, including species information and gene function annotation information; based on a statistical analysis method, carrying out diversity analysis and screening microbial markers and functional genes significantly related to smoking behaviors; constructing a training set and a test set, and training a machine learning model and model evaluation by taking the microbial markers and / or the functional genes as input features; and performing smoking behavior identification on a target sample by using the model, and outputting a prediction result. The accuracy rate of model identification reaches 0.7966, the sensitivity is 0.8750, the specificity is 0.7037, and the method can be applied to health assessment and judicial expertise.

The invention discloses a porcine epidemic diarrhea virus (PEDV) infection resistant Min pig source lactobacillus salivarius LSM231 and application thereof, and belongs to the technical field of microorganisms. The Min pig source lactobacillus salivarius is named as Ligilbacillus salivarius LSM231 and is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 20242330, and the preservation time is October 25, 2024. The Min pig source lactobacillus salivarius has the advantages that the Min pig source lactobacillus salivarius is named as Ligilbacillus salivarius LSM231 and is preserved in the China Center for Type Culture Collection (CCTCC); the screened Min pig source lactobacillus salivarius is symbiotic probiotics in intestinal tracts and is high in safety performance, and experimental results show that the Min pig source lactobacillus salivarius LSM231 has relatively good antibacterial, acid-resistant and cholate-resistant characteristics, has a remarkable PEDV (porcine epidemic diarrhea virus) resisting effect, and can relieve clinical symptoms caused by PEDV infection and promote growth of piglets, so that the Min pig source lactobacillus salivarius LSM231 can be used for preventing and treating the porcine epidemic diarrhea. The compound can replace antibiotics to be used for preparing a micro-ecological preparation for resisting PEDV (porcine epidemic diarrhea virus) infection.

The invention relates to the technical field of microorganisms, in particular to space breeding combined lactobacillus salivarius ZK-88-S and application thereof. The combined lactobacillus salivarius ZK-88-S disclosed by the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC) on December 24, 2024, and the preservation number is CGMCC No.33181; the combined lactobacillus salivarius ZK-88-S can inhibit escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa, fusobacterium nucleatum, porphyromonas gingivalis, streptococcus mutans, streptococcus salivarius, streptococcus gordoni or actinomyces naessii, and can be applied to preparation of medicines, daily necessities or health-care foods for oral treatment and oral cleaning.