554 results about "Saliva" patented technology

The invention discloses a buccal nicotine bag product and a preparation method thereof. The buccal nicotine bag product comprises a content and an outer package, the content is powdery and comprises a nicotine source and an acidic pH regulator; the outer package is a saliva permeable pouch and is used for packaging the content, so that the pH value of the buccal nicotine pouch product in pure water or saliva is smaller than 6.0. Optimizing the pH value to a weakly acidic range (pH lt; a specific buffer system and a slow-release carrier are combined to solve the problems of oral cavity stimulation, flavor limitation and high pH dependence in the using process of an existing nicotine bag, the palatability of the nicotine bag in the using process and the nicotine release efficiency in the mouth consumption process are improved, long-acting and stable nicotine delivery is achieved by controlling release kinetics, the production cost is reduced, and the nicotine bag is suitable for large-scale popularization and application. The consumption experience is improved.

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

The invention belongs to the technical field of medical materials, and particularly relates to a tooth whitening composition and a preparation method thereof, the tooth whitening composition comprises the following components by weight: 5%-15% of hydrogen peroxide, 0.5%-1.5% of a gel matrix, 0.2%-1.0% of a thickener, 5%-10% of a humectant, 3%-8% of propylene glycol, 0.05%-0.2% of a chelating agent, 1%-3% of a sweetener, 0.1%-0.5% of sodium fluoride, and the balance of water. Aiming at the problems that an existing tooth whitening product is relatively low in pH value (most of 4.0-5.0), easy to irritate gingiva and sensitive in tooth manufacturing, and the existing tooth whitening product needs to be stored in a dark place at a low temperature and is short in whitening validity period, the pH value of the product is adjusted to 5.5-6.5, so that the product is close to oral saliva, the irritation can be reduced, the stability of the product can be ensured, the product is not easy to decompose, and the tooth whitening effect is good. Active ingredients are prevented from losing efficacy in advance, and the whitening validity period is prolonged.

The invention discloses a preparation method of high-stability beta-glucan yoghourt. Mixing the sterilized fresh milk with a composite strain consisting of lactobacillus delbrueckii subsp. Bulgaricus, streptococcus salivarius subsp. Thermophilus, bifidobacterium animalis subsp. Lactis, plant lactobacillus, bifidobacterium breve, lactobacillus paracasei, lactobacillus helveticus, lactobacillus rhamnosus and bifidobacterium longum subsp. Longum, and fermenting; and adding beta-glucan into the fermented yoghourt to obtain the high-stability beta-glucan yoghourt. Before beta-glucan is added, the compound bacterial strain is added into the milk, protein in the milk can be gathered under the action of the compound bacterial strain to form a three-dimensional curd network, so that the flowability of a system is reduced, then glucan is added, and the glucan can be uniformly dispersed in curd gaps, so that the glucan is prevented from being excessively combined with the protein in the milk; the stability of a yoghourt system is improved.

The invention relates to the technical field of prebiotics preparation, and discloses a preparation method of prebiotics applied to reproduced areca catechu, and the preparation method comprises the following steps: carrying out enzyme catalysis reaction on sucrose by adopting fructosyl transferase to prepare fructo-oligosaccharide; according to the method, beta-galactosidase is adopted to carry out enzyme catalysis reaction on lactose, so that galactooligosaccharide is prepared; respectively carrying out decoloration, ion exchange, nanofiltration concentration and spray drying on the candy oligosaccharide and the galactooligosaccharide to obtain powder; the method comprises the following steps: mixing fructo-oligosaccharide powder and galactooligosaccharide powder according to a ratio, and uniformly distributing the mixture in a reproduced areca-nut matrix by adopting a spray-drying blending or low-temperature vacuum mixing mode to form a functional reproduced areca-nut product; according to the invention, low-temperature drying is carried out on the product after blending or vacuum mixing, so that the prebiotic areca nuts are released along with saliva in the chewing process, and are selectively utilized by bifidobacteria and lactic acid bacteria after entering the stomach and intestine, thereby achieving the purposes of regulating intestinal flora and improving the health-care function.

The invention belongs to the technical field of electrochemical detection, and discloses an anti-pollution electrochemical saliva sensor based on fluorinated side chain polypeptide as well as a preparation method and application of the anti-pollution electrochemical saliva sensor. The fluorinated side chain polypeptide disclosed by the invention not only has excellent hydrophilicity, can form a dense hydration layer with water molecules to repel pollutants, but also has low surface energy, and the interaction between the pollutants and an interface is remarkably reduced. Through the synergistic effect, the fluorinated side chain polypeptide has better anti-pollution performance compared with traditional zwitterionic polypeptide. The anti-pollution electrochemical sensor constructed on the basis of the fluorinated side chain polypeptide can be used for directly detecting CA15-3 in saliva, the saliva does not need to be pretreated, and the detection accuracy can be comparable with that of a commercial ELISA (Enzyme-Linked Immunosorbent Assay) method.

The invention provides an application of streptococcus salivarius in fatty liver, in particular to an application of streptococcus salivarius in preparation of a product, and the product is used for at least one of the following applications: (a) losing weight or reducing body fat; (b) improving the glucose tolerance of the patient; (c) increasing the sensitivity of the patient to insulin; (d) treating, relieving and preventing liver injury; (e) treating, relieving and preventing non-alcoholic steatohepatitis; (f) fat deposition caused by high-fat and high-cholesterol diet is reduced; (g) reducing blood fat; and / or (h) improving the level of at least one of the following indexes in the liver of the mammal: total cholesterol, triglyceride, low density lipoprotein-cholesterol and free fatty acid.

A spectral sensing device and associated methods for enhanced diagnostic capabilities across medical fields are disclosed. The device incorporates multispectral, hyperspectral, and photoplethysmography technologies to analyze biological features including tongue, oral cavity, saliva, teeth, and other tissues. The system transforms any standard RGB camera into a multispectral imaging device by training machine learning models to associate RGB values with spectral values inside and outside the visible spectrum using measurements from a single pixel detector spectroradiometer. A multimodal neural network with separate processing branches analyzes spectral images, non-spectral images, and tabular data to predict microbiome composition. The system generates health risk assessments by comparing predicted microbial abundances to thresholds associated with various medical conditions. Near-infrared sensing enables blood flow monitoring, subcutaneous imaging, and assessment of physiological parameters. Convolutional neural networks enable spectral reconstruction without requiring the physical device, while supporting continuous monitoring in various form factors.

The invention belongs to the technical field of biomedical treatment and biological fermentation, discloses a metagen composition for effectively inhibiting oral dental caries and application thereof, and aims to solve the problems of great side effect, weak effect and unknown mechanism of the existing dental caries prevention and treatment means. The composition is prepared by mixing a metagen 1 which is prepared by fermenting lactobacillus salivarius Postbio-YY with a metagen 2 which is prepared by fermenting lactococcus lactis Postbio-F3 and lactobacillus paracasei Postbio-P6 step by step. In the preparation process, the active ingredients are reserved by accurately controlling the fermentation pH, time and pasteurization parameters. The composition can be prepared into multiple dosage forms such as toothpaste and the like, can remarkably inhibit the growth of streptococcus mutans and destroy the thallus structure, inhibits biofilm and exopolysaccharide synthesis by down-regulating fimI, wcaJ and wcae genes, is safe and free of side effects, and provides an efficient scheme for decayed tooth prevention and treatment.

The invention relates to a nicotine buccal bag with a content fixing cavity and a preparation method of the nicotine buccal bag. The nicotine buccal bag comprises a bag body, contents and a content fixing wall, the bag body is a saliva permeable bag; the content comprises a nicotine source and a functional capsule; the functional capsule comprises a shell and an inner core; the shell is saliva impermeable and is suitable for being destroyed by external force; the inner core comprises at least one of a pH regulator solution and a flavor provider solution; the content fixing wall and the bag body are relatively fixed, and a closed content fixing cavity is formed by the content fixing wall and the bag body; and a nicotine source and a functional capsule are accommodated in the content fixing cavity. The invention also relates to a preparation method of the nicotine buccal bag. The fixing cavity enables the functional capsule to have a certain and predictable position, and storage and use are convenient.

The invention belongs to the technical field of microorganisms, and particularly relates to combined lactobacillus salivarius and application thereof in female genital tract health. The preservation number of the strain is CCTCC NO: M20231719, and the strain has good bacteriostatic ability and dendritic cell (DC) maturation / activation stimulation ability, has no potential safety problem, can regulate vaginal micro-ecological balance, prevent infection caused by exogenous bacteria, effectively improve tumor immunosuppression microenvironment, and has good application prospects. And the method has very important significance on prevention / treatment of vaginal dysbacteriosis patients, gynecological tumors and precancerous lesions thereof.

The invention relates to the technical field of nursing materials, and discloses an oral and maxillofacial nursing drainage apparatus, the oral and maxillofacial nursing drainage apparatus comprises a main pipe, an auxiliary pipe and a clamping sleeve which are integrally formed, the main pipe is provided with a drainage assembly, the drainage assembly comprises two sets of conical pipes, and the large ends of the two sets of conical pipes are fixedly connected with the two ends of the main pipe respectively. According to the oral and maxillofacial nursing drainage apparatus, by arranging the drainage assembly, when the drainage head is placed on a wound surface, a solid-liquid mixture can be drained, when the drainage cylinder is placed on the wound surface, the drainage cylinder is matched with the drainage hole to drain a liquid drainage object, natural negative pressure drainage force is generated through the height difference, and the drainage object enters the drainage collection bin through the hose, the conical pipe, the main pipe and the bent pipe; the sealing dressing is matched to improve the sealing performance, the auxiliary tube and the threaded locking valve are matched to facilitate drainage object removal, wound surface liquid accumulation, hematocele or necrotic tissue can be sucked out actively under the stable negative pressure, saliva pollution is isolated through the sealing design, and the drainage amount is measured through scale marks.

The invention relates to genetic engineering combined lactobacillus salivarius and application of the genetic engineering combined lactobacillus salivarius. The strain is classified and named as combined lactobacillus salivarius CTMT2, and the preservation number of the strain is CCTCC (China Center for Type Culture Collection) M 2025547. After an NIAAA model is injected into the stomach of an alcoholic liver mouse, the acetaldehyde level of the liver of the mouse is obviously reduced, and the alcoholic fatty liver symptom of the mouse is obviously relieved; after long-term intragastric administration of a high-glucose and high-fat modeling mouse, the acetaldehyde level in excrement of the mouse can be obviously reduced, the progress of liver fibrosis is improved, and good application prospects are achieved.

The utility model belongs to the technical field of auxiliary rehabilitation instruments, and particularly discloses a tongue muscle training device. The tongue muscle trainer comprises a tongue sleeve, a breather pipe and an air pump, and the air pump and the breather pipe are connected through a connecting sleeve; a first groove is formed in the top of a shell of the air pump, and a first boss with a first vent hole is arranged on one side of the first groove; a partition plate is arranged in the middle of the connecting sleeve, and a second boss with a second vent hole is arranged on one side of the partition plate. Through the arrangement of the second boss, saliva flowing down through the ventilation pipe can be prevented from flowing into the top of the shell through the second ventilation hole; the first boss can prevent saliva from flowing into the shell through the first vent hole; the first vent hole and the second vent hole are arranged in a staggered manner, so that saliva flowing down through the second vent hole can be further prevented from directly falling into the shell through the first vent hole.

The utility model relates to a saliva suction tube which comprises a tube body, the tube body comprises a fixed straight flow section, a saliva suction front end and a bent folding section, and the two ends of the bent folding section are connected with the fixed straight flow section and the saliva suction front end respectively. The saliva suction front end is of a conical structure, a plurality of suction holes are formed in the conical surface of the saliva suction front end, and the suction holes are uniformly distributed in the saliva suction front end; a filter screen is arranged in the bent folding section, a tongue protector is arranged on the fixed straight flow section, and the tongue protector is detachably installed on the fixed straight flow section. Compared with the prior art, the device has the advantages of simple structure, flexibility in operation and the like.

Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting5 with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, 5 an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 20 24 28 71 87 23 D ec 2 02 4 2 0 2 4 2 8 7 1 8 7 2 3 D e c 2 0 2 4 A b s t r a c t 5 1 0

The invention discloses an exosome slow-release oral soluble film based on enzyme triggering and a preparation method thereof. The oral soluble film comprises a film forming substrate, a plasticizer, a disintegrating agent, mucous membrane adhesion type enzyme-sensitive nanogel and a stable protection component. Wherein the mucous membrane adhesion type enzyme-sensitive nanogel has a three-layer functional structure: an enzyme-sensitive cross-linking core is formed by maleimide starch through gradient cross-linking, and alpha-1, 4 glucosidic bonds on a starch chain can be hydrolyzed by saliva alpha-amylase; the phospholipid-exosome composite layer is located on the surface of the core, and efficient embedding of the exosome is achieved through a pre-fusion-cold locking process; the mucous membrane adhesion layer is made of thiolated mucous membrane adhesion materials and can form disulfide bonds with oral mucosa. Self-regulation slow release insensitive to saliva alpha-amylase concentration fluctuation is realized through a gradient cross-linked structure, the problems of exosome activity loss, uncontrollable release and weak adhesion are effectively solved, and the exosome is suitable for treatment of oral mucosa diseases.

Apparatuses, systems, and methods for the collection and sampling of agents (including organisms and pathogens) to determine the health of an animal colony. A collection media is configured to collect a sample from a target animal, such as a mouse or rat. The collected sample may include dust, feces, fur, urine, saliva, or other aspect of the target animal's environment.

The utility model discloses a saliva aspirator which comprises a saliva aspirating head, an occlusion part is arranged on the saliva aspirating head, an anti-skid structure is formed on the occlusion part, a cavity is formed in the saliva aspirating head, a plurality of aspirating holes are formed in the saliva aspirating head, and the aspirating holes are communicated with the cavity; one end of the connecting tube is connected with the saliva suction head, and a circulation channel is formed in the connecting tube and communicated with the cavity. According to the saliva aspirator disclosed by the utility model, the friction force between the tooth occlusal surface and the saliva aspirating head can be increased by arranging the anti-slip structure on the occlusal part, so that the saliva aspirating head can be effectively prevented from being separated during use, the reliability of the saliva aspirator during use can be improved, and the aspirating continuity of saliva can be ensured; meanwhile, in the attachment bonding process, the teeth tightly bite the saliva suction head, and the saliva suction head can play a role similar to chewing, so that the invisible orthodontic appliance template is tightly attached to the teeth, and the attachment bonding accuracy and firmness can be improved.

The utility model relates to the technical field of oral corner protection patches, and discloses a disposable oral corner protection patch special for dental operation, which comprises an oral interior part and an oral exterior part arranged on one side of the oral interior part, and J-shaped aluminum sheets are arranged in the oral interior part and the oral exterior part. According to the disposable oral corner protection patch special for dental operation, the J-shaped aluminum sheet is completely wrapped by the medical silica gel, the effects of supporting the appearance of the medical silica gel and adjusting the thicknesses of different oral corners are achieved, the whole patch is made of the medical silica gel, the aluminum sheet is wrapped on the inner side of the patch, the high rebound resilience of the medical silica gel plays a role in buffering the oral corners, and the side face of the patch is in a half-moon arc shape. The medical polyurethane adhesive is attached to the inner side of the oral outer portion, the inner side of the oral inner portion is free of adhesive and smooth, the medical polyurethane adhesive is attached to the inner wall of the oral cavity through opening and closing of the J-shaped aluminum sheet, the outer side surfaces of the oral outer portion and the oral inner portion are rough, and slipping of instruments during operation of a doctor is prevented; the rough surface can prevent the saliva suction tube from slipping and falling off.

The utility model relates to medical auxiliary appliance related technical field more, more specifically, the utility model provides prone position ventilation air cushion, including support pad body and support part, the support part sets up in support pad body, and the support part includes with the face support air cushion, shoulder support air cushion, crotch support air cushion and knee support air cushion corresponding to the position of the limb part, the face support air cushion, shoulder support air cushion, crotch support air cushion and knee support air cushion independently sets up and is respectively through the inflation conduit with the air pump intercommunication, the shoulder support air cushion and knee support air cushion respectively are equipped with phase change material in, the face support air cushion is provided with ventilation groove, is equipped with the collecting box for receiving secretion in ventilation groove, and the collecting box setting in ventilation groove is opposite the mouth part setting, is used for receiving oral cavity secretion (such as saliva), and the secretion in the collecting box is washed and collected regularly by starting negative pressure pump and water pump, avoids the secretion stagnation and influences ventilation function.

Provided are Streptococcus salivarius and compositions comprising Streptococcus salivarius for the treatment of ENT diseases, in particular cancer therapy-induced oral mucositis and respiratory tract infections associated with cancer therapy.

The utility model relates to the technical field of medical instruments, and discloses an oral disinfection and cleaning device which comprises an upper shell, a shell top is arranged at the top of the upper shell, a movable wheel is arranged at the top of the shell top, a rectangular top is arranged at the top of the movable wheel, a first fixing seat is arranged on one side of the top of the rectangular top, and a second fixing seat is arranged on the other side of the rectangular top. A buckle is arranged at the top of the first fixing base, the buckle is connected with the first fixing base in a clamped mode, a threaded hose is fixedly arranged at the top of the buckle, a saliva suction ball is arranged at one end of the threaded hose, and a plurality of saliva suction holes are formed in the surface of the saliva suction ball. The threaded hose is connected with the saliva suction ball and the saliva suction pipe, and the saliva suction ball is driven by the vacuum pump arranged in the upper shell to suck sewage in the oral cavity into the saliva box, so that the throat is prevented from being choked by excessive sewage in the oral cavity, and the interior of the oral cavity is fresh and cool without accumulated water while the oral cavity is flushed.

The embodiment of the utility model discloses a children sputum aspirator which comprises a sputum storage bottle, a connecting pipe, a sputum suction pipe A and a sputum suction pipe B are connected to a bottle cap of the sputum storage bottle, and one end of the connecting pipe is communicated with a negative pressure machine. One end of the sputum suction tube B is connected with a sputum suction head, the sputum suction head comprises a tongue depressor of an oval structure, a guide hole is formed in the middle of the tongue depressor, a negative pressure cavity is formed in the tongue depressor, and the sputum suction tube B is communicated with the interior of the negative pressure cavity; a sputum suction hole communicated with the negative pressure cavity is formed in the surface of the upper portion of the tongue depressor. According to the sputum aspirator, the tongue depressor is placed in the oral cavity of a child, and then the sputum suction tube A is inserted from the guide hole, so that the child cannot bite the sputum suction tube A, the effect of smooth guide can be achieved, the oral cavity of the child cannot be injured, and smooth sputum suction can be conducted; by arranging the negative pressure cavity and the sputum suction hole, saliva and sputum in the oral cavity of the child can be sucked away in time, and the child cannot be choked.

An enzyme obtained from the saliva of waxworms (Galleria mellonella larvae) is disclosed that has the unexpected ability to oxidize and depolymerize untreated polyolefin-derived polymers, such as polyethylene (PE), at room temperature (RT), neutral pH, and short incubation times. The present invention also relates to a method for biodegrading polyolefin-derived polymers using this enzyme.

A sensor device is adapted to detect glucose concentration in saliva of an object, and includes a conductive substrate, a polymer layer, and a carbon nanomaterial unit. The polymer layer is disposed on the conductive substrate and is made from conducting polymer. The carbon nanomaterial unit is disposed on the polymer layer and includes at least one carbon-nanotube layer. The saliva of the object is applied on the carbon nanomaterial unit and an enzyme is added to be mixed with the saliva to detect the glucose concentration in the saliva. A method for making the sensor device is also provided.

A nicotine pouched product is disclosed, the pouched product comprising a pouch composition and a saliva-permeable pouch enclosing said pouch composition, the pouch composition comprising nicotine and a pouch substrate, the pouch substrate comprising water-insoluble fiber, wherein said pouch composition comprises nicotine in an amount of at least 0.25% by weight of the pouch composition, and wherein the pouched product comprises said pouch composition in an amount of no more than 400 mg.

The invention relates to a pharmaceutical composition for repairing oral gingivitis and a preparation method thereof, and belongs to the technical field of biological medicine, the pharmaceutical composition comprises a lactobacillus salivarius fermentation extract, a herba violae extract, golden cicada nymph extract peptide, guava polyphenol and resveratrol; the lactobacillus salivarius fermentation extract is obtained by carrying out aerobic fermentation and anaerobic fermentation on lactobacillus salivarius to obtain a fermentation product, and purifying and extracting the fermentation product through an XAD7HP macroporous adsorption resin column; the philippine violet herb extract is obtained by performing enzymolysis on whole philippine violet herb through pectinase and cellulase and then performing enzymolysis through compound protease to obtain zymolyte, and purifying and extracting the zymolyte through a compound adsorption column. The golden cicada nymph extracted peptide is obtained by purifying and extracting 5kDa zymolyte obtained by performing step-by-step enzymolysis on golden cicada nymphs through papain and trypsin through a Q agarose gel FF adsorption column. All the components are matched for use according to a certain proportion, so that the antibacterial coating is capable of precisely resisting bacteria, has efficient anti-inflammatory and anti-oxidation properties, and is safe and reliable.

The utility model discloses an oral and facial muscle function training device which can be worn between dentition and labial muscle or labial and buccal muscle of a patient, is used for blocking contact between the labial muscle or the labial and buccal muscle and the dentition, and comprises an approximately C-shaped blocking screen and a first expandable part, the first expandable part is at least arranged at the corresponding position, corresponding to the deepest position of the bottom of the vestibular sulcus of the patient, of the outer contour of the blocking screen, and after the oral and facial muscle function training device is worn, the first expandable part expands through saliva infiltration and abuts against the bottom of the vestibular sulcus. Thus, according to the size of the oral cavity space of a patient, the first expandable part expands after being infiltrated by saliva, does not continue to expand after meeting the bottom of the vestibular groove of the patient, and can stably abut against the position, so that the oral and facial muscle function training device can be stably worn between the dentition of the patient and the lip muscle or the lip-buccal muscle; the contact between the labial muscle or the labial cheek muscle and the dentition is blocked.

The application relates to the field of biological medicine, and particularly discloses application of saliva TP17, TP47 and TP15 specific antibodies in preparation of an auxiliary diagnostic product for neurosyphilis. Based on specific antibody immunoglobulin G (IgG) of Treponema pallidum in saliva, combined detection of saliva TP17 / IgG, TP47 / IgG and TP15 / IgG outputs a risk value of neurosyphilis of a subject, or a four combined Logistic regression discriminant model is constructed by combining serum TRUST titers, and the subject is stratified into a low-risk or high-risk group based on a preset judgment threshold, so that the comprehensive recognition capability for neurosyphilis is improved. The saliva is used as a detection sample, and the application has the advantages of non-invasiveness, convenience, easy popularization, repeatable collection and the like, and can be used for early screening, auxiliary diagnosis and clinical path management of neurosyphilis.