77 results about "Iontophoresis" patented technology

The invention relates to the technical field of biomedical sensing and health monitoring, and discloses a noninvasive glucose detection system. The system comprises an interstitial fluid extraction device, a photoelectric sensing module and a main control circuit which are integrated on a flexible substrate. The interstitial fluid extraction device drives subcutaneous interstitial fluid to migrate to the hydrogel interface layer under the action of reverse ion electroosmosis; the photoelectric sensing module receives interstitial fluid through a hydrogel interface layer, a working electrode of the photoelectric sensing module comprises a Cu monatomic imprinting recognition layer, and imprinting holes formed by Cu monatomic sites are specifically coordinated with glucose molecules. The master control circuit controls sampling and determines the glucose concentration based on the photocurrent signal. Noninvasive sampling and monatomic imprinting photoelectric detection are fused, sampling-detection integration is achieved, and the device has the advantages of being noninvasive, painless, high in selectivity, high in interference resistance, comfortable to wear and the like and is suitable for continuous monitoring of blood glucose.

The invention relates to the field of nano-drug delivery preparations, in particular to a traditional Chinese medicine transdermal drug delivery preparation based on a nano-coating technology and a preparation method thereof, the traditional Chinese medicine transdermal drug delivery preparation comprises a liposome-metal organic framework composite carrier, and the composite carrier comprises traditional Chinese medicine active ingredients; a meridian point targeted transdermal enhancer; an iontophoresis device for dynamically sensing skin impedance; the invention relates to an intelligent administration time sequence control system based on a traditional Chinese medicine midnight-noon ebb-flow theory. The liposome-metal organic framework composite carrier is adopted, the similar structure of liposome and skin and the high specific surface area of MOF are fully utilized, efficient encapsulation and transdermal absorption of active ingredients of traditional Chinese medicine are achieved, and compared with a traditional transdermal patch, the drug transdermal absorption rate is increased by 3-5 times.

This invention discloses an iontophoresis gel scleral contact lens and its preparation method, comprising a contact lens frame, a polymer porous microsphere drug-carrying layer loaded with nano-sustained-release drugs, an electrode layer, and a flexible material covering the electrode layer on the contact lens frame, and a gel layer covering the outer side of the contact lens frame. This iontophoresis gel scleral contact lens has a simple structure, facilitates convenient and rapid drug delivery, and provides sustained-release efficacy. It allows patients to self-administer the drug, directly delivering it to the intraocular lesion site, avoiding adverse reactions in other tissues or the whole body, and has a sustained-release function to reduce the frequency of drug administration.

An iontophoresis device includes an outer housing, and a swab subassembly slidingly received within the outer housing that includes an elongated rod, a swab, a conductor extending along the rod and coupled to the swab. The iontophoresis device also includes an additional device subassembly, such as a syringe subassembly, that is slidingly received within the outer housing. The syringe subassembly includes an elongated body for holding a substance, a needle, and a plunger.

Proposed is a self-current-generating skin-applicable patch with a first area in contact with the skin and a second area adjacent to and spaced apart from it, where either area contains a biodegradable metal, decomposable and absorbable through skin contact or reaction with tissue moisture. The patch includes a first electrode layer directly contacts the skin as a thin sheet integrated with the first area and has at least one fluid-transferable penetration part, a second electrode layer of a material with a different standard reduction potential is positioned opposite a skin-contacting side, partially extending to connect electrically to the second area, and a support layer, a hydrophilic sheet of predetermined thickness, is positioned opposite the skin-contacting side, having an ionic solution supported. Thus, sufficient iontophoresis and other micro-current effects with active ingredients are achieved through self-generated micro-current, even without a battery-like external power source.

An iontophoresis device for introducing ions into a living body by means of electrical stimulation via an electrode, the iontophoresis device comprising: a controller; a voltage signal generation unit for adjusting the peak voltage; an output synthesis unit including at least a low-pass filter; an output unit that outputs the pulse signal synthesized by the output synthesis unit to an electrode; an output detection unit that detects the current value output from the output unit and transmits the current value to a controller; when a mode for stepwise increasing the cut-off frequency of the low-pass filter is defined as a first mode and a mode for stepwise decreasing the cut-off frequency of the low-pass filter is defined as a second mode, the controller performs the following current control: a first step of performing the first mode until the current value changes from increasing to decreasing; a second step of switching the first mode to a second mode and implementing the second mode until the current value is changed from increasing to decreasing when the current value is changed from increasing to decreasing in the first step; and a third step of switching the second mode to the first mode when the current value is changed from increasing to decreasing in the second step.

A self-powered intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs is applied to detection and treatment of skin wound infection and can detect the temperature of a wound and surrounding skin in real time and conduct dosing according to needs. According to the intelligent adhesive bandage, the piezoelectric nanometer generator is combined, mechanical energy generated in the daily activity process of a wearer can be converted into electric energy, and the electric energy is used for driving the whole intelligent adhesive bandage to operate. The two temperature measuring units are used for detecting the temperature of the wound and the surrounding skin at the same time, the temperature difference value serves as a relative index for judging whether the wound is infected or not, and the influence of environmental factors on detection is reduced. A three-electrode structure is adopted, on-demand drug delivery is achieved through iontophoresis, and high drug permeability, dosage controllability and drug delivery uniformity are all considered. After the intelligent adhesive bandage is used for treating a mouse with wound infection for three days, the wound recovery rate of the mouse reaches 90.3%, and the realization of temperature detection and on-demand administration is proved. The intelligent adhesive bandage has a good application prospect in detection and treatment of wound infection.

An iontophoresis device capable of reducing skin irritability due to an applied current while enhancing skin permeability of a drug is provided. The iontophoresis device includes a power supply, an electrode electrically connected to the power supply, a drug disposed between skin and the electrode, and a control unit configured to control a current applied to the skin via the electrode. The control unit controls the current so that a pulse current having a pulse frequency of 0.5 Hz or more and 50 Hz or less is applied to the skin.

The utility model provides a joint used for an ion electroosmosis patch and the ion electroosmosis patch, the joint is used for connecting a first electrode and a wire layer, and the joint comprises a bottom layer, a joint body and a covering layer; the bottom layer is an insulating layer and is printed on the first electrode surface; the first end of the bottom layer covers the surface of the first electrode, and the first end of the bottom layer is provided with a first hollow; the lead layer is printed on the bottom layer; the joint body is printed on the bottom layer and the wire layer, and the first end of the joint body partially or completely covers the first hollow part; the second end of the joint body covers the first end of the wire layer; the covering layer is an insulating layer and covers the bottom layer, the connector body and the wire layer. The utility model has the technical effects that the design is reasonable, and the joint of the first electrode and the wire layer is effectively prevented from being contaminated by essence or liquid medicine for beauty to cause oxidation and electrolytic reaction.

The invention provides a partitioned iontophoresis and self-power-generation micro-current composite mask which comprises a mask base body, an iontophoresis functional area and a control module and further comprises a self-power-generation micro-current functional area. The self-generating micro-current functional area is not electrically connected with an external power supply, comprises at least one primary battery unit made of two different metal materials and an electrolyte medium, and spontaneously generates micro-current through an electrochemical principle. Multiple effects of moisturizing, whitening, wrinkle resisting, lifting and tightening and the like are achieved at the same time through one-time nursing, and energy distribution is more reasonable.

Embodiments of the present invention relate to a microcurrent ion patch comprising an electrochromic unit, which allows users to visually confirm the usage state. A microcurrent ion patch comprising an electrochromic unit according to an embodiment of the present invention includes an iontophoresis ion patch and an electrochromic unit electrically connected to both electrodes of the ion patch. The electrochromic unit may comprise: a base thin film; an electrochromic material layer formed on the base thin film; and a hydrogel electrolyte layer formed on the electrochromic material layer.

1. The name of the design product: beauty instrument. 2. The use of the design product: the product is an oval beauty instrument. By supplying current or warm (or cold) from the inside of the main body to the metal plate, the metal plate can apply electric stimulation (EMS, iontophoresis effect) or thermal stimulation to the skin to achieve beauty purposes. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

[Problem] To develop a method with which a medicine such as insulin can be delivered in a minimally invasive manner. [Solution] It was discovered that even types of insulin that form a multimer in aqueous solution can be delivered transdermally in a minimally invasive manner through iontophoresis by holding the insulin or modified insulin in a non-ionic hydrogel.

The invention discloses a non-contact fruit preservation microcapsule preparation as well as a preparation method and application thereof, and relates to the technical field of fruit preservation. The preparation method comprises the following steps: dissolving linalool in a solvent to obtain a linalool solution; dissolving sodium alginate in water to obtain a sodium alginate solution; the linalool solution is used as a core material, the sodium alginate solution is used as a wall material, the linalool solution and the sodium alginate solution are uniformly mixed, and the non-contact fruit fresh-keeping microcapsule preparation is prepared by a microcapsule granulator through ionic gelation and a single-nozzle embedding method. The non-contact fruit fresh-keeping microcapsule preparation prepared by the invention can maintain the storage quality of picked fruits and prolong the shelf life.

The application provides an integrated wearable transdermal iontophoresis patch powered by a moisture generator and a preparation method thereof, and belongs to the technical field of medical devices and biomedical materials. The problems of high distance requirement, large energy loss in the transmission process, inability to provide stable power supply, long-term use, complex device structure and operation of the existing iontophoresis transdermal drug delivery equipment are solved. It comprises a flexible circuit board and two electrode sheets, the flexible circuit board is provided with a power generation module, the positive and negative levels of the power generation module are connected with the two electrode sheets respectively, the power generation module comprises a moisture generator array, the moisture generator array comprises a plurality of moisture generator groups arranged side by side in parallel, the moisture generator group comprises a plurality of moisture generator devices arranged in series, and the moisture generator device comprises an active material, a steel mesh electrode and a graphite paper electrode. It is mainly used for transdermal drug delivery.

The present disclosure relates to transdermal drug delivery compositions for delivering brivaracetam, and uses, processes, methods of preparation and delivery thereof. The present disclosure also relates to iontophoresis drug delivery devices and systems, and methods of treatment comprising such compositions.

The invention relates to methods and system for locally treating a wound (for example, ARDS) of a lung tissue, or mediastinum condition, comprising choosing a target in said tissue requiring treatment; insertion trans-bronchial catheter with mini-ultrasonic therapeutic transducers as close as possible to the target; calibrating contact, calibrating position and irradiating said target with therapeutic ultrasonic waves. Optionally, also providing treatment using phonophoresis and iontophoresis for local administration of drugs into the wound.

An iontophoresis administration device includes: a power source, used to generate the pulsed direct current required to cause a medicinal agent to permeate an administration region of an organism, wherein the power source generates a forward pulsed direct current during a first time period and a reverse pulses direct current during a second period of time; a dielectric layer, configured to be in contact with the administration region, wherein the dielectric layer includes or has attached thereto an active agent that is to permeate the administration region via a pulsed direct current; and at least two electrodes, used to receive the pulsed direct current outputted by the power source, facilitating the provision of the received pulsed direct current to the dielectric layer. The iontophoresis administration device provided by the present disclosure not only increases the skin permeation rate, but is also not likely to irritate or harm the skin.

The present application aims at facilitating diffusion of an active ingredient contained in a liquid agent under a surface layer with a compact structure. A diffusion-facilitating device (100) having a first cylindrical member (110) and a second cylindrical member (120) facilitates diffusion of an active ingredient contained in a liquid agent under a surface layer of an object (e.g., a surface of a human skin or a stratum corneum) when, in a state where the liquid agent is being supplied from a liquid agent supply portion (220) of a liquid agent supply device (200) housed in an internal housing space to the object, an electric current path via the surface layer portion of the object is formed between a first electrode (1151 and / or 1152) formed on a side surface of the first cylindrical member (110) and a second electrode (125) formed on a front end portion of the second cylindrical member (120). That is, the diffusion-facilitating device (100) facilitates diffusion of the active ingredient under the surface layer of the object by an iontophoresis effect.

The invention discloses a wearable plant sensing system and application thereof in plant salt stress monitoring and early warning, and belongs to the technical field of sensor technology and electrochemical analysis. The wearable plant sensing system comprises a flexible sensing module, a reverse ion electroosmosis module, a microfluidic device, a polyvinyl alcohol channel, a flexible battery and a data acquisition and wireless transmission module. The wearable sensor system prepared by the invention has the advantages of flexibility, multiple parameters, remote transmission, good plant surface fitting effect, good detection effect and the like, can realize on-site immediate in-situ detection of K < + >, Na < + > and salicylic acid in living plant tissues, has no influence on plant growth, and has important application prospects in the aspects of plant salt stress monitoring and early warning.

The utility model provides an ionic electroosmosis patch for facial skin. The ionic electroosmosis patch comprises a substrate, a first electrode, a first sub-separation strip, a second electrode, a second sub-separation strip and a wire unit, at least one netted first electrode is printed on the surface of the first electrode surface; a first sub-separation strip is printed on the first connecting surface; at least one second electrode is printed on the surface of the second electrode surface; a second sub-separation belt is printed on the second connecting surface; the second electrode and the first electrode are separated by the separation belt; the plurality of wire units are arranged on the first electrode surface; the first end of the wire unit is connected with the first electrode, and the second end is used as a positive electrode contact; the first hollow part is filled with a conductive material to serve as a negative electrode contact, and the positive electrode contact and the negative electrode contact are both located on the first electrode face of the substrate. The utility model has the technical effects that the design is reasonable, the poor connection is effectively avoided, and the beauty or medical effect is well ensured.

The utility model provides an ion electroosmosis patch for local skin, which comprises a substrate, a first electrode, a separation belt, a second electrode and a wire unit, and is characterized in that the flexible substrate is provided with a main body part and an interface part which are integrally formed; the substrate is provided with a first electrode surface opposite to the facial skin and a second electrode surface facing the facial skin; one first electrode is printed on the surface of the first electrode surface; the second electrode and the first electrode are separated by the separation belt; the interface part is positioned on one side, far away from the separation strip, of the second electrode; the second electrode is provided with a connecting end; the first hollowed-out part is filled with a conductive material and serves as a negative electrode contact, the negative electrode contact is connected with the second electrode, and the positive electrode contact and the negative electrode contact are both located on the first electrode face of the substrate. The utility model has the technical effects that the design is reasonable, and long-time and high-dose key nursing can be conveniently carried out on a part needing key nursing.

The invention discloses a paper-based microfluidic cavity structure and method for in-situ sweat collection and detection, and belongs to the field of wearable body surface sweat monitoring equipment. According to the paper-based microfluidic cavity structure, the sweat reaction area and the flexible hydrophilic substrate layer are connected through the double faced adhesive tape, a hollow cavity micro space for sweat storage and detection is formed, and sufficient sweat can be enriched for accurate detection of a paper-based electrochemical sensor. One-step preparation of the paper-based electrochemical sensor is realized by using the mixed conductive ink prepared from PEDOT: PSS / D-sorbitol / MWCNTS / PB NPs, so that the preparation steps of the sensor are greatly simplified, and the stability and biocompatibility of the sensor are improved. The wearable device can be worn on each part of a human body and is used for local sweat collection and accurate detection in the autonomous sweating process of the human body or after iontophoresis.

The invention relates to the technical field of medicines, in particular to triamcinolone acetonide palmitate nano-emulsion as well as a preparation method and application thereof. The composition comprises a water phase and an oil phase, the oil phase comprises triamcinolone acetonide palmitate, a surfactant, oil and a cosurfactant; the water phase comprises an osmotic pressure regulator and a charge modifier. In the triamcinolone acetonide palmitate nano-emulsion, the content ratio of the oil to the surfactant is (3: 1)-(1: 1). According to the preparation method of the triamcinolone acetonide palmitate nano-emulsion provided by the invention, a phase transformation method is adopted, and the average particle size of the triamcinolone acetonide palmitate nano-emulsion is accurately controlled by changing the dosage of the oil phase and the surfactant, so that the triamcinolone acetonide palmitate nano-emulsion suitable for eye iontophoresis is obtained. Meanwhile, it is further found that the permeability of the triamcinolone acetonide palmitate nano-emulsion can be remarkably enhanced by adding cations into the triamcinolone acetonide palmitate nano-emulsion, and the delivery efficiency is enhanced.

A computer-implemented method for measuring skin conductance of a writing instrument's user, including: applying a DC voltage to user's fingers contacting the writing instrument during a writing session with the writing instrument; measuring a current generated by reverse iontophoresis following applying the DC voltage; calculating an average skin conductance over a specific timeframe from the measured current; storing calculated average skin conductance data as historical data; comparing the average skin conductance to historical data from the same user or to reference data from a group of users; and providing an indication to the user in case that the skin conductance has decreased and / or the calculation results.

The invention relates to a skin-like chip simulation platform based on a microfluidic technology. The skin-like chip simulation platform sequentially comprises a skin-like layer, a skin-like layer, a cytoplasm matrix simulation layer and an interstitial fluid circulation layer from top to bottom, a hole array is arranged on the imitated skin layer; an interstitial fluid enrichment cavity communicated with the hole array is formed in the simulated cortex, and the interstitial fluid enrichment cavity is provided with an enrichment outlet and an enrichment inlet; an interstitial fluid micro-channel is arranged in the cytoplasm matrix simulation layer, one end of the interstitial fluid micro-channel is communicated to the enrichment inlet, and the other end of the interstitial fluid micro-channel is communicated to the interstitial fluid flowing layer; an interstitial fluid storage cavity is formed in the interstitial fluid circulation layer and is provided with a storage cavity outlet and a storage cavity inlet; the device further comprises an interstitial fluid circulation channel. The skin-like chip simulation platform designed by the invention can accurately simulate the human skin environment, provides a simulation test platform for novel extraction electrode design, parameter optimization and safety evaluation of a counter ion electroosmosis technology, and remarkably reduces the preclinical research risk and cost of new technology development.

A selenium-enriched biotin scalp care essence spray and its preparation method belong to the field of scalp care technology. The spray components are: selenium yeast extract, pearl active peptides, hair follicle repair core enzyme complex, biotin, plant extract micropowder, and the remainder being excipients and deionized water, with a pH of 5.0-5.5. The selenium yeast extract contains ≥60% selenocysteine; the pearl active peptides have a molecular weight <1kDa and an amino acid content ≥90mg / mL; the hair follicle repair core enzyme complex contains ≥2000U / mg superoxide dismutase and ≥50U / mg transglutaminase; and the plant extract micropowder is extracted using supercritical CO2. The use of ultrasonic high-pressure homogenization, iontophoresis encapsulation, and nitrogen-filled aluminum bottle packaging technology solves the problems of low transdermal penetration rate of active ingredients (traditional formulations <8%, this invention increases it to 28%) and poor stability.

The present application relates to the technical field of transdermal drug delivery, and in particular to an iontophoresis patch with current homogenization function and an iontophoresis system. The iontophoresis patch comprises a substrate support layer, a first electrode, a second electrode, an electric field homogenization ring, and a drug-loaded layer. The first electrode has a hollow annular structure with a center, and the second electrode is insulated and separated from the first electrode. The electric field homogenization ring is located on the inner side of the first electrode and is insulated and separated from the first electrode. The volume conductivity of the electric field homogenization ring is greater than the volume conductivity of the stratum corneum of human skin and less than the volume conductivity of the first electrode and the second electrode. The drug-loaded layer covers the surface of the first electrode or covers the surfaces of the first electrode and the second electrode, respectively. The present application solves the problems of current hot spots caused by the umbilical depression of traditional electrodes and the skin irritation and low drug transdermal efficiency caused by the edge electric field concentration of the annular electrode.

The invention relates to methods and system for locally treating a wound (for example, ARDS) of a lung tissue, or mediastinum condition, comprising choosing a target in said tissue requiring treatment; insertion trans-bronchial catheter with mini-ultrasonic therapeutic transducers as close as possible to the target; calibrating contact, calibrating position and irradiating said target with therapeutic ultrasonic waves. Optionally, also providing treatment using phonophoresis and iontophoresis for local administration of drugs into the wound.

The invention relates to a myopia intervention device and a treatment method thereof. The myopia intervention device comprises a host and a replaceable intelligent eye pad connected with the host, the intelligent eye pad is designed to be of a multi-layer structure, and sequentially comprises a hydrogel contact layer used for being attached to the skin and conducting electricity from the contact eye skin to the inside; the iontophoresis layer is used for generating pulse current to drive nutrient substances in blood to directionally permeate to sclera tissues; the optical layer is used for emitting monochromatic light with different wavelengths to act on cells of the retina; the micro magnetic field layer is used for generating a micro magnetic field with specific form and strength; the host is used for controlling the iontophoresis electrode layer, the optical layer and the micro-magnetic field layer to work cooperatively according to a preset time sequence and performing intervention treatment on eyes; according to the technical scheme, the myopia intervention treatment effect can be improved.