Composition and device structure for iontophoresis

Abstract

Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.

Description

BACKGROUND OF INVENTION[0001] The present invention relates to a composition for iontophoresis and a device structure using it, more specifically, a composition for iontophoresis to deliver an active ingredient to an organism safely and efficiently using electric driving power and a device structure using it.[0002] Iontophoresis is an accelerating system for transdermal absorption using electricity as an outside stimulus. The principal is that it accelerates penetration of the drug's molecules through the skin barrier based on the moving power of positively charged molecules and negatively charged molecules from the anode to the cathode and from the cathode to the anode, respectively, in the electric field generated between the anode and the cathode mainly by energizing with current (see Journal of Controlled Release, vol. 18, 213-220, 1992; Advanced Drug Delivery Review, 119, 1992; Pharmaceutical Research, vol. 3, pp. 318-326, 1986).[0003] Iontophoresis is a method of making the ch...

AI Technical Summary

Problems solved by technology

For example, synthesized narcotic analgesics have only narrow therapeutic range because they have not only a potent analgetic action but also cause significant adverse reactions such as respiratory depression.

The excessive dosing, however, cause the adverse reactions such as anorexia while they are needed to be frequently administered repetitively to increase their therapeutic effect.

Most of the drugs are known, however, to be not absorbable since they are decomposed by digestive juices in the gastrointestinal tracts or hydrolized by decomposing enzymes of the gastrointestinal walls.

Therefore, as for administration of these drugs, injection is usually conducted to avoid adverse reactions and because adequate efficacy control cannot be expected by oral administration.

Injections, however, give much pain to patients and become a burden since they can not be self-administered, even more so particularly in the case of the above described Calcitonin which is needed to be frequently administered repetitively.

However, it is known that the materials in the preparation to control the pH include the ion species which have the similar polarity to the drug (competitive ions) causing to reduce the

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