Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery

a technology of iontophoretic drug delivery and renal sympathetic nerve, which is applied in the field of renal denervation and endovascular drug delivery, can solve the problems of increasing recovery time, conventional methods of renal denervation, heart disease and death, etc., and achieves the effect of facilitating iontophoresis drug delivery

Inactive Publication Date: 2012-10-11
TYCO HEALTHCARE GRP LP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0010]The electric field may be continuous or pulsed direct current. During use, the disclosed catheter produces an electric potential gradient

Problems solved by technology

Chronic elevated blood pressure, or hypertension, is a significant cause of heart disease and death and afflicts millions worldwide.
There exist several disadvantages of conventional methods of renal denervation for the treatment of hypertension.
Conventional methods involve the application of intense heat to several discrete sites of the renal artery, which can b

Method used

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  • Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
  • Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
  • Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery

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Embodiment Construction

[0029]Particular embodiments of the present disclosure are described hereinbelow with the accompanying notes and drawings; however, it is to be understood that the disclosed embodiments are merely examples of the disclosure, which may be embodied in various forms. The terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting Well-known and / or repetitive functions and constructions are not described in detail to avoid obscuring the present disclosure in unnecessary or redundant detail. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present disclosure in virtually any appropriately detailed structure.

[0030]As used herein, the term “proximal,” as is traditional, shall refer to the end of the instrument that is closer to the user, while t...

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Abstract

A system for denervation of the renal sympathetic nerve and iontophoresis drug delivery includes an iontophoresis catheter fitted with a drug coated balloon. The balloon contacts the vessel wall when inflated. One or more electrodes are associated with a surface of the balloon, and may be disposed on an outer surface of the balloon. The electrodes are operably coupled to an energy source configured to produce a bipolar or monopolar electric field between two balloon electrodes and/or between one balloon electrode and another electrode placed in contact with the patient's body. The drug-delivery catheter produces an electric potential gradient within adjacent tissue, that, facilitates iontophoresis delivery of a drug. The catheter can also include a store of one or more drugs to be delivered to the targeted tissue.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of, and priority to, U.S. Provisional Patent Application No. 61 / 473,569 filed on Apr. 8, 2011, the entire contents of which are incorporated by reference herein for all purposes.BACKGROUND[0002]1. Technical Field[0003]The present disclosure is related to renal denervation and endovascular drug delivery. More particularly, the present disclosure is related to an iontophoretic catheter system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery.[0004]2. Description of Related Art[0005]Chronic elevated blood pressure, or hypertension, is a significant cause of heart disease and death and afflicts millions worldwide. Generally, one having chronic blood pressure of over 140 mm Hg systolic and 90 mm Hg diastolic is classified as suffering from hypertension. It is believed that renal sympathetic nerve activity initiates, and sustains, the elevation of blood pressure. The ren...

Claims

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Application Information

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IPC IPC(8): A61N1/30A61M25/10A61F2/958
CPCA61M25/0074A61M25/10A61M37/00A61M2025/105A61M2025/1086A61N1/0448A61N1/3605A61N1/303A61N1/0444A61N1/30A61N1/325A61N1/36007A61N1/044
Inventor MEYER, PETER F.
Owner TYCO HEALTHCARE GRP LP
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