83 results about "Sympathetic nerve" patented technology

The invention discloses a hearing aid health analysis method based on a physiological signal monitoring function. The method comprises the following steps: collecting physiological signal data of a user in real time through a multi-mode biosensor array integrated on a hearing aid body; the hearing aid body comprises a digital signal processor and a wireless communication module; the physiological signal data at least comprises a brain wave signal, a skin electric response signal and a temporal artery pulse signal; performing motion artifact elimination processing on the physiological signal data through an adaptive filtering algorithm; performing feature extraction on the preprocessed physiological signal by using an embedded health analysis engine to generate a composite health feature vector containing a sympathetic nerve activity index, cognitive load measurement and a cardiovascular function index; and dynamically generating a health risk assessment report based on an association relationship between the composite health feature vector and a preset hearing scene, the bone conduction vibration unit and the audio synthesis module of the hearing aid body output graded health alarm signals.

The invention discloses a near-infrared light controllable irradiator for astroganglion stimulation, which comprises a physiological signal acquisition module used for acquiring a near-infrared light sensing signal of a carotid artery area in real time; the signal processing module is used for performing variational mode decomposition on the near-infrared sensing signal and extracting a heart rate component; the autonomic nerve analysis module is used for receiving the heart rate component and calculating the excitement ratio of sympathetic nerves to parasympathetic nerves; a deep learning model is arranged in the control signal generation module, and an optical parameter control signal is generated according to the heart rate cycle characteristics and the excitement ratio; and the light adjusting module is used for receiving the light parameter control signal so as to control the emission of near-infrared light. According to the invention, the output of the infrared light can be adjusted according to the physiological signal of the human body, intelligent adjustment is realized, the near-infrared light stimulation better fits the individual condition, and the pertinence and effectiveness of the stimulation are effectively improved.

The invention relates to the technical field of signal analysis, in particular to an acute pain assessment method and system based on an EDA signal, and the method comprises the following steps: collecting a skin electrical activity EDA signal of a subject; calculating an individual time-varying sympathetic nerve activity TVSymp curve; the method comprises the following steps: constructing a priori knowledge base containing a standardized pain response sympathetic nerve SpainSymp template; inputting the EDA signal and the individual TVSymp curve into a PCVAE model, fusing features and decoupling the features into pain common features and individual specific features; carrying out pain intensity classification, and reconstructing and generating a standardized SpainSymp curve of which individual specific characteristics are removed; and outputting the pain intensity classification result and the dynamic change trend of the standardized SpainSymp curve in real time. By adopting the method, the pain-induced physiological reaction and individual baseline variation can be effectively decoupled and separated from the mixed EDA signal, the interference of individual difference is avoided, and the method has the characteristics of high accuracy and strong real-time performance.

The application discloses a hearing aid health analysis method based on physiological signal monitoring function, comprising the following steps: collecting physiological signal data of a user in real time through a multi-modal biological sensor array integrated in a hearing aid body; the hearing aid body comprises a digital signal processor and a wireless communication module; the physiological signal data at least comprises an electroencephalogram signal, a galvanic skin response signal and a temporal artery pulse signal; the physiological signal data is subjected to motion artifact elimination processing through an adaptive filtering algorithm; a preprocessed physiological signal is subjected to feature extraction through an embedded health analysis engine, and a composite health feature vector comprising a sympathetic nerve activity index, a cognitive load metric and a cardiovascular function index is generated; a health risk assessment report is dynamically generated based on the association between the composite health feature vector and a preset hearing scene; and a graded health alarm signal is output through a bone conduction vibration unit and an audio synthesis module of the hearing aid body.

The application provides a medicinal composition for treating sympathetic cervical spondylosis, which is prepared from the following raw medicinal materials in the following proportions: Gualoupi 5-15 parts, Xiebai 5-15 parts, Fabanxia 8-20 parts, Guizhi 5-15 parts, Fushen 10-30 parts, Shenghuangqi 20-60 parts, Chao Wu Zhu 5-15 parts, Shengbaishu 10-30 parts, Muxiang 5-15 parts, Shigai 8-20 parts, Zhizhi 5-15 parts, Longgu 8-20 parts, and Muli 8-20 parts. The application also provides a preparation method and use of the medicinal composition. The medicinal composition has the effects of benefiting qi and activating yang, promoting qi and dredging collaterals, and eliminating swelling and relieving pain, and the compatibility of the medicinal materials can synergistically enhance the effects, so that the medicinal composition has good effects on sympathetic cervical spondylosis and can effectively reduce the clinical recurrence rate. In addition, the medicinal composition has fewer raw medicinal materials, is convenient to prepare and use, has high clinical compliance of patients, and has a good clinical application prospect.

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers. A method can include transluminally delivering a distal portion of an elongated shaft of a catheter to a target renal blood vessel and at least partially inhibiting sympathetic neural activity of a renal nerve. The method includes determining a post-neuromodulation level of one or more biomarkers after at least partially inhibiting the sympathetic neural activity of the renal nerve, wherein the level of the one or more biomarkers directly or indirectly correlates with sympathetic nervous activity in the patient. The method can include comparing the post-neuromodulation level to a predetermined level for the one or more biomarkers, wherein the renal neuromodulation procedure is classified as at least partially successful if the post-neuromodulation level differs from the predetermined level.

The application discloses a high-frequency electromagnetic wave bidirectional regulation and control sympathetic nerve activity hypertension treatment device, which comprises a master control box, a movable mechanical arm, an irradiation assembly, a sensor assembly and a power distribution assembly; a single-chip microcomputer control unit and a radio frequency generating circuit are arranged in the master control box, and the power distribution assembly is arranged in the master control box; one end of the movable mechanical arm is fixed to the master control box, and the other end is connected with the irradiation assembly; the irradiation assembly is connected with the radio frequency generating circuit; the sensor assembly is connected with the single-chip microcomputer control unit, is used for collecting physiological information, feeds back to the single-chip microcomputer control unit and adjusts radio frequency output parameters. The application can realize accurate directional irradiation of high-frequency electromagnetic waves on a target sympathetic nerve region, combines physiological information, dynamically adjusts radio frequency output parameters in real time, and improves the accuracy, stability and individual adaptability of sympathetic nerve regulation.

A method of cardiac treatment to provide a synergetic therapeutic effect of lowering the hyperactive sympathetic response observed in microvascular disease (MVD) and heart failure (HF) pathologies and promoting cardiac remodeling of left ventricular hypertrophy in a patient. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure, and ablating a greater splanchnic nerve to reduce stressed blood volume with exertion. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure and at least one of: ablating pulmonary artery nerves of the patient to reduce cardiac sympathetic activity; and ablating pulmonary vein nerves of the patient to reduce arrhythmias.

A method of interrupting sympathetic stimulation to the cardiovascular system of a patient in need thereof includes navigating a probe of a hand-held cryogenic therapy apparatus to a stellate ganglion or an autonomic tissue area peripheral to the stellate ganglion of the patient, the probe including a needle configured to produce a cooling zone for focused cryogenic therapy, aligning the needle with one or more desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion, and producing the cooling zone to provide cryogenic therapy to the desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion at a temperature sufficient to cause axonotmesis of the nerves.

The invention provides a special flushing and sucking double-cavity tube for thoracoscope sympathetic nerve surgery, which comprises a flushing and sucking double-cavity mechanism and a protective telescopic mechanism, the flushing and sucking double-cavity mechanism integrates an electrocoagulation hook main body and a negative pressure suction channel to realize electrocoagulation and synchronous suction, and the protective telescopic mechanism is sleeved outside the flushing and sucking double-cavity mechanism to realize synchronous suction. The protective sleeve is composed of a plurality of layers of sleeves capable of sliding mutually and a protective hose at the tail end, and in a non-working state, the protective hose extends forwards to cover a suction head and the tip end of the electrocoagulation hook, so that the effects of preventing damage and blocking are achieved; the invention relates to the technical field of medical apparatuses and instruments, in particular to a disposable aspirator which can retract backwards to expose a working end during working, solves the problems that in the prior art, the instruments need to be frequently switched, a suction head is prone to being blocked, and tissue is prone to being damaged by the tips of the instruments, and has the advantages of being convenient to operate, high in integration level and good in safety. The device is particularly suitable for thoracoscope sympathetic nerve cutting or blocking operations.

A sympathetic nerve activation agent includes a compound represented by Structural Formula (1).

Provided is a heart-rate control device capable of adjusting the heart rate of a subject to a desired value between a base heart rate and an active heart rate, such as a heart rate immediately after physical exercise. The heart-rate control device includes a detector for detecting heartbeat information of a subject, an input unit to which information on a target value relating to a heart rate of the subject is to be inputted, a difference extracting unit for determining a difference between the target value and a current value relating to the heart rate of the subject, the current value being calculated from the heartbeat information, a pattern generating unit for generating a stimulus pattern depending on the difference so that the current value approaches the target value, the stimulus pattern being a combination of a sympathetic nerve stimulus for stimulating sympathetic nerves, a parasympathetic nerve stimulus for stimulating parasympathetic nerves, and an initialization stimulus for preventing stimulus saturation of the sympathetic nerves or the parasympathetic nerves, and an output unit for outputting the sympathetic nerve stimulus, the parasympathetic nerve stimulus and the initialization stimulus to the subject in accordance with the stimulus pattern.

The invention discloses a system for radiofrequency ablation renal sympathetic nerve removal and nerve excitability measurement, and relates to the technical field of medical instruments. The device comprises a control handle, the end of the control handle is connected with a guide pipe, the free end of the guide pipe is connected with a bent section, and the upper portion of the control handle is rotationally connected with an adjusting handle; the ablation monitoring unit is connected to the tail end of the control handle through a cable and used for monitoring and controlling the ablation temperature; and the nerve excitability monitoring unit is connected to the bottom end of the control handle through a cable and is used for monitoring nerve excitability. By adopting a mode of combining temperature sensor acquisition and nerve excitability monitoring, real-time and visual nerve excitability change feedback and temperature feedback are provided for doctors, the ablation effect is accurately judged in an assisted manner, and the operation flexibility and safety are improved.

Methods of systemically treating neuropathic pain in a spinal cord injured patient by administering a calcitonin gene-related peptide (CGRP) inhibitor are provided. In some variations, pain-producing tissues correlated with sympathetically mediated central neuropathic pain in spinal cord injured (SCI) patients, were acquired.

The invention provides a perioperative period stress identification method and system based on HRV intelligent monitoring, and relates to the technical field of medical data processing, and the method comprises the steps: determining segmented periods in a perioperative period of a monitoring period; determining a plurality of HRV data and physiological index data, and a first input vector and a second input vector of the HRV data and the physiological index data; determining time period coding information according to the segmented time period and the starting time of the monitoring period; and determining a stress index through a stress identification model. According to the system and the method, various signals of the patient in the perioperative period can be acquired through the wearable physiological signal acquisition device, whether the patient has a stress response in each subsection period or not is identified by utilizing the characteristic that the HRV signal can reflect the sympathetic nerve condition, and various physiological index data are utilized for auxiliary judgment; according to the method, the accuracy and confidence of recognition are improved, various collected data can be continuously acquired and updated, and the timeliness of recognition is improved.

The application belongs to the field of animal model construction, and particularly relates to a brain protein induced lung edema animal model after brain injury and a construction method and application thereof. The construction method comprises the following steps: injecting brain protein into a rat to construct. The brain protein induced lung edema animal model after brain injury can simulate lung edema caused by brain protein leakage after brain injury, and avoids lung edema induced by sympathetic nerve excitation caused by nerve injury. The prepared animal model has the advantages of good stability, good repeatability and long survival time.

This invention relates to an intraoperative nerve localization system for thoracic sympathectomy, belonging to the field of minimally invasive surgical assistance and medical information processing technology. During thoracoscopic surgery, this system identifies and analyzes candidate regions of the thoracic sympathetic nerve by acquiring intraoperative thoracoscopic images and patient physiological signals. It also verifies the sympathetic nerve properties of the target structure by combining the physiological functional responses induced by intraoperative nerve stimulation. Based on this, the system fuses and calculates the image structural information and functional response information to generate the localization reliability of the thoracic sympathetic nerve, providing the surgeon with localization references and safety prompts for thoracic sympathectomy. This system enables real-time, objective localization of the thoracic sympathetic nerve during surgery, reducing reliance on surgeon experience, lowering the risk of mis- or missed sympathectomy, and improving the safety and consistency of thoracic sympathectomy, thus possessing high clinical application value.

The application relates to a radiofrequency ablation system and a radiofrequency ablation clamp for renal sympathetic denervation, which comprises an upper jaw and a lower jaw that can be opened and closed relative to each other, the upper jaw is provided with upper jaw radiofrequency electrodes, the lower jaw is provided with lower jaw radiofrequency electrodes, the lower jaw comprises a lower jaw main body in an arc structure with an axis extending along a left-right direction, a lower electrode seat made of insulating material corresponding to each lower jaw radiofrequency electrode is movably arranged on the lower jaw main body in a circumferential direction, each lower jaw radiofrequency electrode is fixed on the corresponding lower electrode seat, the upper jaw radiofrequency electrodes are at least three, each upper jaw radiofrequency electrode is arranged in a left-right direction at intervals, the lower jaw radiofrequency electrodes are at least three, each lower jaw radiofrequency electrode is arranged in a left-right direction at intervals, and the radiofrequency ablation clamp further comprises an electrode seat driving mechanism for driving the circumferential movement of the corresponding upper electrode seat and lower electrode seat. The purpose of the application is to provide a radiofrequency ablation system capable of retaining part of parasympathetic nerves and a radiofrequency ablation clamp used in the radiofrequency ablation system.

The invention provides a portable vagus nerve stimulation treatment device and a use method thereof, and the device comprises an ear stimulation assembly which is used for stimulating the vagus nerve of the ear of a patient; the acquisition module is used for acquiring the intensity of a sympathetic nerve signal of the patient; and the host is used for controlling stimulation parameters of the ear stimulation assembly according to the intensity of the sympathetic nerve signal. The ear sympathetic nerves of a patient can be stimulated through the device, and then the patient is treated.

This invention provides a multi-dimensional monitoring and assessment method for sleep disorders at high altitudes, comprising: S1, concurrently collecting respiratory signals, blood oxygen saturation and pulse wave (PPG), heart rate / ECG, body movement and position, and environmental parameters such as altitude / air pressure and temperature and humidity during nighttime sleep; S3, performing sleep / wake discrimination and detecting apnea, hypoventilation, and blood oxygen desaturation events based on structured data, and statistically analyzing event metrics; S4, calculating the frequency domain characteristics of heart rate variability (HRV) from RR interval sequences to obtain a sympathetic nerve activity proxy index; S5, weightedly fusing the event metrics, oxygenation metrics, and sympathetic proxy into a comprehensive score R and performing hierarchical interpretation; S6, fitting an individualized risk trajectory model to the cross-night scoring sequence and outputting short-term predictions. This method enables the construction of individualized adaptation trajectories and short-term prediction models in a real-world high-altitude environment, shifting from "static results" to "process evaluation."

Disclosed is an artificial intelligence wearable device for treating primary palmar hyperhidrosis by means of non-invasive regulation and control of the thoracic sympathetic nerve, which comprises: a main controller, a pulse generator, a first stimulation electrode, a second stimulation electrode, and a third stimulation electrode. The pulse generator is used for generating specific pulse signals for the first, second and third stimulation electrodes. The arrangement position of the first stimulation electrode corresponds to a body surface part of the radial nerve at the wrist, the arrangement position of the second stimulation electrode corresponds to a body surface part of the median nerve at the wrist, and the arrangement position of the third stimulation electrode corresponds to a body surface part of the ulnar nerve at the wrist. Primary palmar hyperhidrosis is treated by means of pulsed electrical stimulation on the radial nerve, the median nerve, and the ulnar nerve. The device is non-invasive and non-destructive to human nerves and normal tissues, has no serious complications such as postoperative compensatory hyperhidrosis and sympathetic denervation, carries no risks such as general anesthesia accidents, provides continuous treatment along with intelligent recognition, is convenient, effective and safe, and can maintain a long-term curative effect.

This invention belongs to the field of biomedical technology, specifically relating to the application of TLR1 receptor inhibitors in the preparation of products for treating hypertension. Existing drugs used clinically for hypertension have varying mechanisms of action. This study discovers a novel mechanism for treating hypertension: by inhibiting TLR1 receptors in juxtaglomerular cells of the kidney and hepatocytes of the liver, sympathetic nerve excitation-induced renin synthesis and glucocorticoid-induced angiotensinogen synthesis are suppressed, thereby inhibiting angiotensin II levels. This mechanism and method provide a new treatment option for hypertension, particularly neurogenic hypertension, and can also exhibit synergistic effects with existing therapeutic drugs. This invention identifies the TLR1 receptor as a novel target for treating hypertension. Currently, there are no developed and applied hypertension treatment drugs mediated by TLR1 receptors. This invention provides sufficient theoretical and experimental basis for the development of novel antihypertensive drugs.

The invention discloses targeted prebiotic plant extraction dietary powder for conditioning hypertension and a preparation method thereof. According to the present invention, the lactobacillus plantarum CECT5716, the bifidobacterium lactis BLa80 and other strains selected in the formula can regulate the renin-angiotensin system balance by inhibiting the activity of the angiotensin converting enzyme so as to reduce the vasosystolic pressure from the neuroendocrine level; hawthorn flavone and pueraria isoflavone directly act on blood vessels to expand peripheral arteries, improve coronary artery blood flow and enhance blood vessel elasticity; the gamma-aminobutyric acid serving as a neurotransmitter can relieve sympathetic nerve hyperexcitation and reduce blood pressure fluctuation caused by emotion or pressure. Meanwhile, prebiotics such as resistant dextrin provide nutrients for probiotics, promote generation of intestinal short-chain fatty acids, activate a vascular endothelium protection pathway through an intestinal-metabolic axis, form a triple antihypertensive network of strain regulation, plant intervention and flora synergy, and cover different pathological links of blood pressure rise.

The application discloses application of a norepinephrine inhibitor in preparation of a medicine for treating or relieving corneal limbal stem cell deficiency, and belongs to the technical field of medicines.The experiment proves that sympathetic nerves are excessively activated in a mouse model of corneal limbal stem cell deficiency, and the release of norepinephrine is increased, and the experiment proves that 6-hydroxydopamine hydrochloride can destroy sympathetic nerves to inhibit the release of norepinephrine, and a tyrosine hydroxylase inhibitor can inhibit the synthesis of norepinephrine, and both can further relieve the symptoms of corneal limbal stem cell deficiency.The norepinephrine inhibitor can improve the corneal limbal microenvironment, reduce corneal neovascularization, reduce corneal epithelialization, enhance corneal transparency and relieve corneal edema, and provides a new direction and a new way for the pathogenic mechanism and intervention target of corneal limbal stem cell deficiency, and has a wide application prospect.

The application is suitable for the technical field of medical equipment, and provides an ablation catheter and an ablation device. The ablation catheter comprises: a catheter assembly; and an ultrasonic generating device arranged in the catheter assembly, wherein the ultrasonic generating device comprises a driving assembly and a generating assembly connected with the driving assembly, the driving assembly is used for driving the generating assembly to vibrate, and the generating assembly is used for emitting ultrasonic waves and converging the ultrasonic waves at a focal point, and the focal point is arranged outside the catheter assembly. The ablation device comprises the ablation catheter. The ablation catheter provided by the application is characterized in that the ultrasonic generating device comprises the driving assembly and the generating assembly, and the ultrasonic waves emitted by the generating assembly can be converged to form the focal point outside the blood vessel wall, so that the ultrasonic waves can have relatively large energy at the focal point, thereby ablation of the sympathetic nerves at the corresponding position is realized. At the position where the ultrasonic waves penetrate the blood vessel wall, the ultrasonic waves are relatively dispersed and carry relatively low energy, so that the blood vessel wall is heated relatively little, thereby the damage of the ultrasonic waves to the blood vessel wall can be relieved.

A device and method are taught for stimulating sympathetic nerves toward mitigating negative impacts to hematopoiesis. An autonomic nerve actuator and stimulator system with a graphic user interface (GUI), controller circuit which converts treatment parameters into a series of Building Block Waveforms (BBW) which are output to Current / Voltage Driver Circuitry (CDC) whose electrical stimulus (ES) outputs are coupled to one or more electrodes and / or electrode arrays positioned proximal specific nerve situations. The use of this in combination with conventional chemotherapy treatments, such as use of carboplatin, was found to significantly enhance hematopoiesis, with improvements in white and red blood cell counts, platelet concentration and hemoglobin concentration, in addition to other measurable characteristics which increased survival rates in the experimental groups tested.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

The invention provides a neuroinflammation dual-targeting sound-sensitive liposome as well as a preparation method and application thereof. The neuroinflammation dual-targeting sound-sensitive liposome comprises a liposome, a sound-sensitive agent entrapped in the liposome and an antibody modified on the surface of the liposome, the sound-sensitive agent is benzothiadiazole-triphenylamine, and the structural formula of the sound-sensitive agent is shown in the specification. And the antibody comprises an anti-TMEM119 antibody and an anti-NAT antibody. The neuroinflammation dual-targeting sound-sensitive liposome can target sympathetic neurons and microglial cells at a neuroinflammation part, has a neural immune regulation effect under ultrasonic activation, can be used for preparing a diagnosis and treatment agent for diagnosis and treatment integration of myocardial ischemia reperfusion injury, and realizes diagnosis and treatment integration of myocardial ischemia reperfusion injury.

In some aspects thereof, the present invention discloses compositions and methods for treating premature ejaculation utilizing tamsulosin at a 0.2 milligram dose administered orally or transdermally every 48 hours. Tamsulosin functions as a selective antagonist of alpha-1a and 1b adrenergic as well as 5HT1A serotonergic receptors implicated in seminal emission pathways. The quantity and frequency of dosing provides an optimal degree of reversible receptor blockade to mildly inhibit sympathetic and serotonergic mediated smooth muscle contraction kinetics governing seminal fluid secretion and transport. This marginally suppresses rate of emission to prolong intercourse without profoundly arresting physiological processes underlying ejaculation.

System and methods for monitoring and / or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subject's skin, and a signal detector configured to detect electrical signals using the electrodes. The system also includes a signal processor configured to receive the electrical signals to generate filtered signals, the filter configured to attenuate at least signals having frequencies corresponding to heart muscle activity during a heartbeat. The signal processor is also configured to identify a skin nerve activity using the filtered signals, estimate a sympathetic nerve activity using the identified skin nerve activity, and further to generate a report indicative of the estimated sympathetic nerve activity. In some aspects, the system further includes a signal generator to deliver the electrical stimulation to the subject's skin.