236 results about "Sympathetic nerve" patented technology

The present invention provides a method of affecting physiological disorders by stimulating a specific location along the sympathetic nerve chain. Preferably, the present invention provides a method of affecting a variety of physiological disorders or pathological conditions by placing an electrode adjacent to or in communication with at least one ganglion along the sympathetic nerve chain and stimulating the at least one ganglion until the physiological disorder or pathological condition has been affected.

The present invention provides a method of affecting physiological disorders by stimulating a specific location along the sympathetic nerve chain. Preferably, the present invention provides a method of affecting a variety of physiological disorders or pathological conditions by placing an electrode adjacent to or in communication with at least one ganglion along the sympathetic nerve chain and stimulating the at least one ganglion until the physiological disorder or pathological condition has been affected.

The present invention provides a method of affecting physiological disorders by stimulating a specific location along the sympathetic nerve chain. Preferably, the present invention provides a method of affecting a variety of physiological disorders or pathological conditions by placing an electrode adjacent to or in communication with at least one ganglion along the sympathetic nerve chain and stimulating the at least one ganglion until the physiological disorder or pathological condition has been affected.

The present invention provides a device and assembly for electrically and / or chemically stimulating individual ganglion and a plurality of ganglia of the nervous system, and particularly to ganglia of the sympathetic nerve chain. A device is provided that generally wraps around an individual ganglion and conforms to the shape of the ganglion without exerting excessive pressure on the ganglion to damage the ganglion. An assembly is also provided that includes an axially elongated shaft that can be positioned adjacent to the sympathetic nerve chain and that can receive a plurality of ganglion stimulators that can slidably engage with the outer surface of the shaft. As additional ganglia are desired to be stimulated, each of the plurality of ganglion stimulators can be added to the shaft to engage the outer surface of the shaft and can be positioned adjacent to the ganglia desired to be stimulated.

The present invention is an apparatus and method for controlling blood pressure by stimulating the cardiac afferent sympathetic nerves. The invention may be implemented in a medical device having a pressure sensor for sensing blood pressure, an electrode for providing electrical signals to the cardiac afferent sympathetic nerves, and a controller for providing signals to the electrode as a function of blood pressure signals received from the pressure sensor.

At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and / or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.

A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.

Apparatus (18) for treating a condition of a subject is provided. An electrode device (100) is adapted to be coupled to longitudinal nervous tissue (40) of the subject, and a control unit (50) is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.

A radiosurgical method for treating cardiorenal disease of a patient, the method including directing radiosurgery radiation from outside the patient towards one or more target treatment regions encompassing sympathetic ganglia of the patient so as to inhibit the cardiorenal disease. In an exemplary embodiment, the method further includes acquiring three dimensional planning image data encompassing the first and second renal arteries, planning an ionizing radiation treatment of first and second target regions using the three dimensional planning image data so as to mitigate the hypertension, the first and second target regions encompassing neural tissue of or proximate to the first and second renal arteries, respectively, and remodeling the target regions by directing the planned radiation from outside the body toward the target regions.

Methods and devices to treat discogenic lumbar back pain are disclosed. Electrodes are implanted within the anterior epidural space of the patient. A pulse generator that is connected to the electrodes delivers electrical impulses to sympathetic nerves located within the posterior longitudinal ligament (PLL) of the lumbar spine and outer posterior annulus fibrosus of the intervertebral disc. In alternate embodiments, energy directed to nerves in the PLL may be from light or mechanical vibrations, or the nerves may be cooled. The electrodes may also be used diagnostically to correlate spontaneous nerve activity with spinal movement, fluctuations in autonomic tone and the patient's experience of pain. The electrodes may also be used to generate diagnostic evoked potentials. The diagnostic data are used to devise parameters for the therapeutic nerve stimulation. Automatic analysis of the data may be incorporated into a closed-loop system that performs the nerve stimulation automatically.

There is disclosed heart treatment equipment in which it is possible to carry out controlling of a preventive treatment after an anti-tachyarrhthmia treatment in order to execute prevention and treatment of a fatal arrhythmia and the anti-tachyarrhythmia treatment is carried out by controlling tachyarrhythmia prevention means and tachyarrhythmia treatment means (tachyarrhythmia termination means) according to the result of detecting occurrence of tachyarrhythmia. In the anti-tachyarrhythmia treatment, there is provided with a structure for reducing or stopping the activation current with respect to the vagus nerve or a repression current with respect to the sympathetic nerve after a supply of an electroshock to the heart such as cardioversion, defibrillation or the like, so that it is possible to prevent deterioration of hemodynamics, recurrence of fatal arrhythmia and supraventicular arrhythmia such as atrial fibrillation or the like.

The invention discloses a sympathetic nerve denervation ablation catheter system inside arteria renalis. The system comprises an ablation catheter, a guide catheter, a control handle, an ablation generator and a guide catheter control handle which can be arranged optionally. The ablation catheter comprises a catheter section and an ablation section from the near end to the far end in sequence, wherein the front end of the catheter body further comprises a controllable bending section and is connected with the control handle by the catheter body; and the ablation section comprises at least two independent structures, wherein an ablation head is arranged on at least one independent structure. With the adoption of the sympathetic nerve denervation ablation catheter system, multi-point ablation can be simultaneously achieved, so that the ablation effect is monitored during an operation in real time and mechanical stability is better.

A sleep state measuring apparatus includes an autonomic nerve index obtaining unit that obtains a user's autonomic nerve index; and a sleep periodicity index calculating unit that calculates a sleep periodicity index based on a temporal change of the autonomic nerve index and a change in a user's sleeping cycle, wherein the sleep periodicity index indicates whether the user is sleeping or not according to a user's ideal sleeping cycle as an index, or a dominance index calculating unit that calculates a parasympathetic nerve dominance index which shows dominance of a parasympathetic nerve index included in the autonomic nerve index with respect to a sympathetic nerve index included in the autonomic nerve index for a user during sleep.

There is provided a method of treating a patient comprising: screening a patient suffering from signs and / or symptoms of at least one medical condition secondary to increased sympathetic tone; selecting the patient for treatment by ablation of at least one neural structure containing sympathetic nerves to reduce the sympathetic tone, the neural structure comprises one or more of: celiac ganglion, superior mesenteric ganglion, inferior mesenteric ganglion, aorticorenal ganglion; selecting a target of at least one measurable parameter affected by the sympathetic tone; ablating at least a portion of the neural structure to deactivate the portion of the neural structure; monitoring changes in the at least one measurable parameter; comparing the at least one measurable parameter to the selected target; and performing another ablation of the same neural structure, and / or another neural structure, based on the comparison.

A system and method is described to map the renal artery prior to an ablation in order to a-priori identify the location of the sympathetic nerves. In specific embodiments, the nerve modulating energy may be electrical or optical.

The invention provides a radio frequency ablation (RFA) catheter system for denervation of sympathetic nerves in renal arteries. The system comprises an ablation catheter, a control handle, a guiding catheter and an ablation generating device and can be provided or not provided with an independent guiding catheter control handle, wherein the ablation catheter is formed by a catheter body section and an ablation section from near end to far end in sequence. The system is characterized in that the front end of the catheter body section also comprises a controllable bending section; the controllable bending section is connected with the control handle by the catheter body section; at least two independent structures are installed on the ablation section; and an ablation head is installed on at least one independent structure. The system can carry out multipoint ablation simultaneously, monitors the ablation effect during operation in real time, and has better mechanical stability.

The invention provides a multifunctional ablation catheter system for denervation of sympathetic nerves in renal arteries. The system comprises an ablation catheter, a control handle and an ablation generating device and can be provided or not provided with a guiding catheter, wherein the ablation catheter is formed by a catheter body section and an ablation section from near end to far end in sequence. The system is characterized in that the front end of the catheter body section also comprises a controllable bending section; the controllable bending section is connected with the control handle by the catheter body section; at least two independent structures are installed on the ablation section; and an ablation head is installed on at least one independent structure. The system can carry out multipoint ablation simultaneously, monitors the ablation effect during operation in real time, and has better mechanical stability.

At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and / or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.

The invention discloses a radio frequency cable controlled ablation catheter system for removing a sympathetic nerve from a renal artery. The system comprises an ablation catheter, a control handle and an ablation generation device, wherein a guiding catheter can be arranged or is not arranged. The ablation catheter sequentially consists of a catheter body section and an ablation section from a near end to a far end, and is characterized in that the front end of the catheter body section also comprises a controllable bending section; the controllable bending section is connected with the control handle through the catheter body section; and the ablation section is provided with at least two independent structures, and an ablation head is arranged on at least one independent structure. The system can simultaneously perform multi-point ablation, monitors an ablation effect in real time during operation, and has relatively high mechanical stability.

At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and / or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.

An intravascular catheter for peri-vascular and / or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and / or nerve fibers in the outer layer or deep to the outer layer of the vessel. A method of treating hypertension involves injecting an ablative fluid such as ethanol deep into zones in the wall of the renal artery such that the zones of fluid merge to form a circumferential ablation ring at a depth which ablates sympathetic nerves while minimizing injury to interior layers of the vessel wall.

A sleep state measuring apparatus includes an autonomic nerve index obtaining unit that obtains a user's autonomic nerve index; and a sleep periodicity index calculating unit that calculates a sleep periodicity index based on a temporal change of the autonomic nerve index and a change in a user's sleeping cycle, wherein the sleep periodicity index indicates whether the user is sleeping or not according to a user's ideal sleeping cycle as an index, or a dominance index calculating unit that calculates a parasympathetic nerve dominance index which shows dominance of a parasympathetic nerve index included in the autonomic nerve index with respect to a sympathetic nerve index included in the autonomic nerve index for a user during sleep.

An intravascular catheter for peri-vascular and / or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and / or nerve fibers in the outer layer or deep to the outer layer of the vessel. A method of treating hypertension involves injecting an ablative fluid such as ethanol deep into zones in the wall of the renal artery such that the zones of fluid merge to form a circumferential ablation ring at a depth which ablates sympathetic nerves while minimizing injury to interior layers of the vessel wall.

The invention discloses an evaluating system of depressive disorder degree quantization. The system comprises an electrocardio and pulse wave integral detection device, a data transmission device and a data processing platform. The invention further discloses an evaluating method of depressive disorder degree quantization. The method comprises the following steps that firstly, human physiological information under different states is acquired through a multi-state comprehensive test platform; secondly; HRV characteristic parameters under the different states are obtained on the basis of the heart rate variability analysis principle; thirdly, the function balance states of sympathetic nerves and pneumogastric nerves in the automatic nervous system are evaluated; fourthly, a depressive disorder degree quantization evaluation model is built, and the depressive disorder degree level of a tested person is evaluated fast and objectively. The system and method belong to the technical field of computer-aided diagnosis, depressive disorder degree quantization evaluation is achieved, the blank of the technical field of depressive disorder inspection is filled up, and the system and method are easy and convenient to implement, save medical resources and have the good clinic practicality.

The invention provides a catheter suitable for realizing radiofrequency ablation in blood vessels such as a renal artery and the like. The catheter comprises a control handle (5), a main body section (1), a bendable section (2) and an electrode (4) from a proximal end to a distal end. A draw wire (10) penetrates through the inside of the catheter in an extension manner and is controlled by the control handle (5). The renal artery radiofrequency ablation catheter is characterized by further comprising a tail straight section (3), and the electrode (4) is fixed on the tail straight section (3); and one end of the draw wire is fixed at the distal end of the tail straight section (3), and the draw wire (10) can extend on different sides in the tail straight section (3) and the bendable section (2) along the axis of the catheter. The catheter is applicable to renal arteries with different inner diameters, and renal artery sympathetic nerve radiofrequency ablation operation by the aid of the catheter is simple, safe and reliable.

A sleep condition measuring apparatus includes a determination unit configured to determine a first timing indicating that the user has fallen asleep and a second timing indicating that the user has waken up, based on body motion of a user, an acquisition unit configured to acquire a first index indicating activity of a sympathetic nerve of the user and a second index indicating activity of a parasympathetic nerve of the user, based on a pulse wave interval of the user, a calculation unit configured to calculate a dominance level of the second index over the first index every predetermined time, and a calculation unit configured to calculate a third index indicating quality of sleep of the user from the first timing until the second timing, using the dominance level and a weight decreasing as time elapses from the first timing.

A method of treating a temporary arrest of intestinal peristalsis includes inducing at least one of an electric current, an electric field and an electromagnetic field in a sympathetic nerve chain of a mammal to block and / or modulate inhibitory nerve signals thereof such that intestinal peristalsis function is at least partially improved.

A system for use in a renal denervation procedure includes a catheter having proximal and distal end portions, a sensor configured to sense a condition of one or more nerves, the sensor operatively associated with the distal end portion of the catheter, and at least one electrode disposed on the distal end portion of the catheter for delivering energy to renal tissue. A catheter includes a catheter body defining a distal end portion and a proximal end portion, and a sensor for sensing a renal sympathetic nerve, the sensor disposed on the distal end portion of the catheter body, wherein the sensor is configured to sense an electromagnetic signal from the renal sympathetic nerve.

The invention discloses a bidirectionally controllable saline-perfusion renal artery radiofrequency ablation catheter. The catheter comprises an ablation electrode tip, a cannula, and a control handle provided with a control valve connected successively. The ablation electrode tip or the cannula is provided with a saline infusion hole. Two sides of the rear end of the ablation electrode tip are connected with two traction filaments. A fixed pulley is arranged in the control handle. The two traction filaments are wound around the fixed pulley and then connected with the control valve. The control valve of the invention can control the bidirectional bending of the ablation electrode tip. The ablation electrode tip can enter a distorted or angled renal artery without catheter rotation. Besides, a bidirectional control mode can guarantee a good adherence to a blood vessel wall in a multipoint ablation process of the ablation electrode tip, and therefore has an advantage of strong control performance. In addition, continuous saline perfusion can prevent the ablation electrode tip temperature from being too high, and avoid impedance increase caused by ablation position incrustation, thereby effectively removing the renal artery sympathetic nerve and improving the ablation security.