45 results about "Sympathetic nerve" patented technology

The invention relates to the technical field of signal analysis, in particular to an acute pain assessment method and system based on an EDA signal, and the method comprises the following steps: collecting a skin electrical activity EDA signal of a subject; calculating an individual time-varying sympathetic nerve activity TVSymp curve; the method comprises the following steps: constructing a priori knowledge base containing a standardized pain response sympathetic nerve SpainSymp template; inputting the EDA signal and the individual TVSymp curve into a PCVAE model, fusing features and decoupling the features into pain common features and individual specific features; carrying out pain intensity classification, and reconstructing and generating a standardized SpainSymp curve of which individual specific characteristics are removed; and outputting the pain intensity classification result and the dynamic change trend of the standardized SpainSymp curve in real time. By adopting the method, the pain-induced physiological reaction and individual baseline variation can be effectively decoupled and separated from the mixed EDA signal, the interference of individual difference is avoided, and the method has the characteristics of high accuracy and strong real-time performance.

The application discloses a hearing aid health analysis method based on physiological signal monitoring function, comprising the following steps: collecting physiological signal data of a user in real time through a multi-modal biological sensor array integrated in a hearing aid body; the hearing aid body comprises a digital signal processor and a wireless communication module; the physiological signal data at least comprises an electroencephalogram signal, a galvanic skin response signal and a temporal artery pulse signal; the physiological signal data is subjected to motion artifact elimination processing through an adaptive filtering algorithm; a preprocessed physiological signal is subjected to feature extraction through an embedded health analysis engine, and a composite health feature vector comprising a sympathetic nerve activity index, a cognitive load metric and a cardiovascular function index is generated; a health risk assessment report is dynamically generated based on the association between the composite health feature vector and a preset hearing scene; and a graded health alarm signal is output through a bone conduction vibration unit and an audio synthesis module of the hearing aid body.

The application provides a medicinal composition for treating sympathetic cervical spondylosis, which is prepared from the following raw medicinal materials in the following proportions: Gualoupi 5-15 parts, Xiebai 5-15 parts, Fabanxia 8-20 parts, Guizhi 5-15 parts, Fushen 10-30 parts, Shenghuangqi 20-60 parts, Chao Wu Zhu 5-15 parts, Shengbaishu 10-30 parts, Muxiang 5-15 parts, Shigai 8-20 parts, Zhizhi 5-15 parts, Longgu 8-20 parts, and Muli 8-20 parts. The application also provides a preparation method and use of the medicinal composition. The medicinal composition has the effects of benefiting qi and activating yang, promoting qi and dredging collaterals, and eliminating swelling and relieving pain, and the compatibility of the medicinal materials can synergistically enhance the effects, so that the medicinal composition has good effects on sympathetic cervical spondylosis and can effectively reduce the clinical recurrence rate. In addition, the medicinal composition has fewer raw medicinal materials, is convenient to prepare and use, has high clinical compliance of patients, and has a good clinical application prospect.

The application discloses a high-frequency electromagnetic wave bidirectional regulation and control sympathetic nerve activity hypertension treatment device, which comprises a master control box, a movable mechanical arm, an irradiation assembly, a sensor assembly and a power distribution assembly; a single-chip microcomputer control unit and a radio frequency generating circuit are arranged in the master control box, and the power distribution assembly is arranged in the master control box; one end of the movable mechanical arm is fixed to the master control box, and the other end is connected with the irradiation assembly; the irradiation assembly is connected with the radio frequency generating circuit; the sensor assembly is connected with the single-chip microcomputer control unit, is used for collecting physiological information, feeds back to the single-chip microcomputer control unit and adjusts radio frequency output parameters. The application can realize accurate directional irradiation of high-frequency electromagnetic waves on a target sympathetic nerve region, combines physiological information, dynamically adjusts radio frequency output parameters in real time, and improves the accuracy, stability and individual adaptability of sympathetic nerve regulation.

A method of cardiac treatment to provide a synergetic therapeutic effect of lowering the hyperactive sympathetic response observed in microvascular disease (MVD) and heart failure (HF) pathologies and promoting cardiac remodeling of left ventricular hypertrophy in a patient. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure, and ablating a greater splanchnic nerve to reduce stressed blood volume with exertion. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure and at least one of: ablating pulmonary artery nerves of the patient to reduce cardiac sympathetic activity; and ablating pulmonary vein nerves of the patient to reduce arrhythmias.

A method of interrupting sympathetic stimulation to the cardiovascular system of a patient in need thereof includes navigating a probe of a hand-held cryogenic therapy apparatus to a stellate ganglion or an autonomic tissue area peripheral to the stellate ganglion of the patient, the probe including a needle configured to produce a cooling zone for focused cryogenic therapy, aligning the needle with one or more desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion, and producing the cooling zone to provide cryogenic therapy to the desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion at a temperature sufficient to cause axonotmesis of the nerves.

The invention provides a special flushing and sucking double-cavity tube for thoracoscope sympathetic nerve surgery, which comprises a flushing and sucking double-cavity mechanism and a protective telescopic mechanism, the flushing and sucking double-cavity mechanism integrates an electrocoagulation hook main body and a negative pressure suction channel to realize electrocoagulation and synchronous suction, and the protective telescopic mechanism is sleeved outside the flushing and sucking double-cavity mechanism to realize synchronous suction. The protective sleeve is composed of a plurality of layers of sleeves capable of sliding mutually and a protective hose at the tail end, and in a non-working state, the protective hose extends forwards to cover a suction head and the tip end of the electrocoagulation hook, so that the effects of preventing damage and blocking are achieved; the invention relates to the technical field of medical apparatuses and instruments, in particular to a disposable aspirator which can retract backwards to expose a working end during working, solves the problems that in the prior art, the instruments need to be frequently switched, a suction head is prone to being blocked, and tissue is prone to being damaged by the tips of the instruments, and has the advantages of being convenient to operate, high in integration level and good in safety. The device is particularly suitable for thoracoscope sympathetic nerve cutting or blocking operations.

Provided is a heart-rate control device capable of adjusting the heart rate of a subject to a desired value between a base heart rate and an active heart rate, such as a heart rate immediately after physical exercise. The heart-rate control device includes a detector for detecting heartbeat information of a subject, an input unit to which information on a target value relating to a heart rate of the subject is to be inputted, a difference extracting unit for determining a difference between the target value and a current value relating to the heart rate of the subject, the current value being calculated from the heartbeat information, a pattern generating unit for generating a stimulus pattern depending on the difference so that the current value approaches the target value, the stimulus pattern being a combination of a sympathetic nerve stimulus for stimulating sympathetic nerves, a parasympathetic nerve stimulus for stimulating parasympathetic nerves, and an initialization stimulus for preventing stimulus saturation of the sympathetic nerves or the parasympathetic nerves, and an output unit for outputting the sympathetic nerve stimulus, the parasympathetic nerve stimulus and the initialization stimulus to the subject in accordance with the stimulus pattern.

The application belongs to the field of animal model construction, and particularly relates to a brain protein induced lung edema animal model after brain injury and a construction method and application thereof. The construction method comprises the following steps: injecting brain protein into a rat to construct. The brain protein induced lung edema animal model after brain injury can simulate lung edema caused by brain protein leakage after brain injury, and avoids lung edema induced by sympathetic nerve excitation caused by nerve injury. The prepared animal model has the advantages of good stability, good repeatability and long survival time.

This invention relates to an intraoperative nerve localization system for thoracic sympathectomy, belonging to the field of minimally invasive surgical assistance and medical information processing technology. During thoracoscopic surgery, this system identifies and analyzes candidate regions of the thoracic sympathetic nerve by acquiring intraoperative thoracoscopic images and patient physiological signals. It also verifies the sympathetic nerve properties of the target structure by combining the physiological functional responses induced by intraoperative nerve stimulation. Based on this, the system fuses and calculates the image structural information and functional response information to generate the localization reliability of the thoracic sympathetic nerve, providing the surgeon with localization references and safety prompts for thoracic sympathectomy. This system enables real-time, objective localization of the thoracic sympathetic nerve during surgery, reducing reliance on surgeon experience, lowering the risk of mis- or missed sympathectomy, and improving the safety and consistency of thoracic sympathectomy, thus possessing high clinical application value.

The application relates to a radiofrequency ablation system and a radiofrequency ablation clamp for renal sympathetic denervation, which comprises an upper jaw and a lower jaw that can be opened and closed relative to each other, the upper jaw is provided with upper jaw radiofrequency electrodes, the lower jaw is provided with lower jaw radiofrequency electrodes, the lower jaw comprises a lower jaw main body in an arc structure with an axis extending along a left-right direction, a lower electrode seat made of insulating material corresponding to each lower jaw radiofrequency electrode is movably arranged on the lower jaw main body in a circumferential direction, each lower jaw radiofrequency electrode is fixed on the corresponding lower electrode seat, the upper jaw radiofrequency electrodes are at least three, each upper jaw radiofrequency electrode is arranged in a left-right direction at intervals, the lower jaw radiofrequency electrodes are at least three, each lower jaw radiofrequency electrode is arranged in a left-right direction at intervals, and the radiofrequency ablation clamp further comprises an electrode seat driving mechanism for driving the circumferential movement of the corresponding upper electrode seat and lower electrode seat. The purpose of the application is to provide a radiofrequency ablation system capable of retaining part of parasympathetic nerves and a radiofrequency ablation clamp used in the radiofrequency ablation system.

The invention provides a portable vagus nerve stimulation treatment device and a use method thereof, and the device comprises an ear stimulation assembly which is used for stimulating the vagus nerve of the ear of a patient; the acquisition module is used for acquiring the intensity of a sympathetic nerve signal of the patient; and the host is used for controlling stimulation parameters of the ear stimulation assembly according to the intensity of the sympathetic nerve signal. The ear sympathetic nerves of a patient can be stimulated through the device, and then the patient is treated.

This invention provides a multi-dimensional monitoring and assessment method for sleep disorders at high altitudes, comprising: S1, concurrently collecting respiratory signals, blood oxygen saturation and pulse wave (PPG), heart rate / ECG, body movement and position, and environmental parameters such as altitude / air pressure and temperature and humidity during nighttime sleep; S3, performing sleep / wake discrimination and detecting apnea, hypoventilation, and blood oxygen desaturation events based on structured data, and statistically analyzing event metrics; S4, calculating the frequency domain characteristics of heart rate variability (HRV) from RR interval sequences to obtain a sympathetic nerve activity proxy index; S5, weightedly fusing the event metrics, oxygenation metrics, and sympathetic proxy into a comprehensive score R and performing hierarchical interpretation; S6, fitting an individualized risk trajectory model to the cross-night scoring sequence and outputting short-term predictions. This method enables the construction of individualized adaptation trajectories and short-term prediction models in a real-world high-altitude environment, shifting from "static results" to "process evaluation."

This invention belongs to the field of biomedical technology, specifically relating to the application of TLR1 receptor inhibitors in the preparation of products for treating hypertension. Existing drugs used clinically for hypertension have varying mechanisms of action. This study discovers a novel mechanism for treating hypertension: by inhibiting TLR1 receptors in juxtaglomerular cells of the kidney and hepatocytes of the liver, sympathetic nerve excitation-induced renin synthesis and glucocorticoid-induced angiotensinogen synthesis are suppressed, thereby inhibiting angiotensin II levels. This mechanism and method provide a new treatment option for hypertension, particularly neurogenic hypertension, and can also exhibit synergistic effects with existing therapeutic drugs. This invention identifies the TLR1 receptor as a novel target for treating hypertension. Currently, there are no developed and applied hypertension treatment drugs mediated by TLR1 receptors. This invention provides sufficient theoretical and experimental basis for the development of novel antihypertensive drugs.

The application discloses application of a norepinephrine inhibitor in preparation of a medicine for treating or relieving corneal limbal stem cell deficiency, and belongs to the technical field of medicines.The experiment proves that sympathetic nerves are excessively activated in a mouse model of corneal limbal stem cell deficiency, and the release of norepinephrine is increased, and the experiment proves that 6-hydroxydopamine hydrochloride can destroy sympathetic nerves to inhibit the release of norepinephrine, and a tyrosine hydroxylase inhibitor can inhibit the synthesis of norepinephrine, and both can further relieve the symptoms of corneal limbal stem cell deficiency.The norepinephrine inhibitor can improve the corneal limbal microenvironment, reduce corneal neovascularization, reduce corneal epithelialization, enhance corneal transparency and relieve corneal edema, and provides a new direction and a new way for the pathogenic mechanism and intervention target of corneal limbal stem cell deficiency, and has a wide application prospect.

A device and method are taught for stimulating sympathetic nerves toward mitigating negative impacts to hematopoiesis. An autonomic nerve actuator and stimulator system with a graphic user interface (GUI), controller circuit which converts treatment parameters into a series of Building Block Waveforms (BBW) which are output to Current / Voltage Driver Circuitry (CDC) whose electrical stimulus (ES) outputs are coupled to one or more electrodes and / or electrode arrays positioned proximal specific nerve situations. The use of this in combination with conventional chemotherapy treatments, such as use of carboplatin, was found to significantly enhance hematopoiesis, with improvements in white and red blood cell counts, platelet concentration and hemoglobin concentration, in addition to other measurable characteristics which increased survival rates in the experimental groups tested.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

The invention provides a neuroinflammation dual-targeting sound-sensitive liposome as well as a preparation method and application thereof. The neuroinflammation dual-targeting sound-sensitive liposome comprises a liposome, a sound-sensitive agent entrapped in the liposome and an antibody modified on the surface of the liposome, the sound-sensitive agent is benzothiadiazole-triphenylamine, and the structural formula of the sound-sensitive agent is shown in the specification. And the antibody comprises an anti-TMEM119 antibody and an anti-NAT antibody. The neuroinflammation dual-targeting sound-sensitive liposome can target sympathetic neurons and microglial cells at a neuroinflammation part, has a neural immune regulation effect under ultrasonic activation, can be used for preparing a diagnosis and treatment agent for diagnosis and treatment integration of myocardial ischemia reperfusion injury, and realizes diagnosis and treatment integration of myocardial ischemia reperfusion injury.

The invention relates to the technical field of medical instruments, and particularly discloses an ablation electrode which comprises a needle tube, an ablation mechanism and a driving mechanism, the ablation mechanism is connected to the far end of the needle tube and provided with a plurality of ablation ends capable of moving in the radial direction of the needle tube, electrode plates are arranged at the ablation ends, and the electrode plates are evenly distributed in the circumferential direction of the needle tube at intervals; the driving mechanism drives the ablation mechanism to be switched between an opening state and a closing state, and in the opening state, the electrode slices protrude outwards to form an annular ablation area. The electrode plates are annularly distributed after being expanded, the attaching distance between the electrode plates and the blood vessel wall can be flexibly adjusted according to the inner diameter of the renal artery, the problem that non-coplanar electrode plates cannot adapt to blood vessels with different tube diameters is solved, meanwhile, the annularly distributed electrode plates can form complete energy coverage on the same radial section, ablation gaps are avoided, and the ablation efficiency is improved. Therefore, the sympathetic nerve fiber is comprehensively blocked, and the long-term effectiveness of blood pressure control is improved.

The invention belongs to the technical field of thrombus removal, and discloses a sublingual sympathetic nerve targeting-based thrombus removal method, which can promote the loosening, decomposition or dissolution of thrombus by applying selective stimulation to a sublingual area and inducing the change of hemodynamics or endogenous fibrinolytic system. The supralingual sympathetic nerve can be acted by combining electrical stimulation, ultrasonic, optical or thermal means, and synergistic thrombus cleaning can be realized by matching with a drug carrier or ultrasonic microbubbles sensitive to stimulation. According to the method, autonomous adjustment can be achieved through closed-loop control, and the method can also be used in cooperation with conventional means such as mechanical thrombus extraction and medicine thrombolysis. Compared with the prior art, the medicine dosage and systemic side effects can be reduced, the operation risk is reduced, the thrombus removing efficiency is remarkably improved, and the good clinical application prospect is achieved.

An apparatus includes a catheter assembly having a catheter with a catheter body and an end effector connected with a distal end of the catheter. The catheter assembly optionally includes an outer sheath or introducer tool. The end effector includes a spine assembly having a plurality of spines. An electrode is associated with each spine of the spine assembly. The electrodes are longitudinally staggered along their respective spines. The spines extend outward from a longitudinal axis of the catheter body such that the spine define a circular arrangement. This arrangement with the longitudinally spaced electrodes defines a helical array such that an elongated circumferential ablation pattern is achieved.

A method for improving an ejection fraction of a patient in need thereof, including positioning a pulmonary artery manipulation device in a target blood vessel, within the pulmonary vasculature of the patient; and impairing the activity of at least one sympathetic nerve, nerve fiber or neuron, using the pulmonary artery manipulation device, to denervate the target blood vessel, thereby improving the ejection fraction of the patient.

The application provides a method and system for decoding emotional arousal, and relates to the field of affective computing. The method comprises: collecting electrodermal signals under emotional stimulation; performing preprocessing on the electrodermal signals; processing the preprocessed electrodermal signals through a sympathetic nerve inversion network to obtain network inversion values representing sympathetic nerve activation levels; performing inverse mapping of the network inversion values through an emotional arousal inverse mapping network to obtain predicted values of emotional arousal, wherein the sympathetic nerve inversion network and the emotional arousal inverse mapping network constitute an end-to-end emotional arousal decoding model, the loss function of the emotional arousal decoding model comprises a weighted sum of physiological loss and psychological loss, the physiological loss is used to calculate the difference between the network inversion values of the sympathetic nerve activation levels and theoretical inversion values, and the psychological loss is used to calculate the difference between the predicted values and label values. The application solves the problem of inaccurate calculation of emotional arousal.

This invention discloses a method for detecting epileptic seizure signals based on multimodal gating fusion to resist artifacts. First, a rigorous signal quality preprocessing method based on intersection is implemented, retaining only temporal windows that simultaneously meet all modal quality thresholds, ensuring that the main classification model operates only on globally reliable data. Second, a motion feature extraction module and a dynamic gating fusion module are introduced, overcoming the limitations of static splicing by dynamically weighting the contributions of inertia and electromyography features based on global context. Finally, through a skin conductance feature extraction module and a skin conductance gating residual module, low-frequency autonomic nerve features are used as soft gating to modulate high-frequency motion representations, preventing key sympathetic arousal indicators from being masked. This effectively suppresses false alarms caused by non-epileptic movements using autonomic nerve context, achieving highly sensitive and robust epileptic seizure signal detection through a classification head module.

The invention relates to the technical field of data processing, and discloses a hydrocephalus assessment method and system based on a bladder pressure dynamic monitoring device. The hydrocephalus assessment method based on the bladder pressure dynamic monitoring device comprises the steps that wrist sympathetic nerve and lumbosacral electromyographic signals are collected and filtered; extracting a specific frequency band power spectrum integral value and a root-mean-square value to fuse and calculate an equivalent bladder pressure value; calculating a detrusor muscle activity index, a compliance index and a night fluctuation coefficient to form a pressure mode; obtaining pressure mode calculation improvement rate judgment reactivity before and after liquid discharge; and calculating a comprehensive improvement index through a weighting algorithm to determine a surgical indication level. The problem that in the prior art, continuous non-invasive monitoring and objective quantitative evaluation cannot be conducted on the bladder function of an iNPH patient is solved, and the accuracy of cerebrospinal fluid drainage test effect evaluation is improved.

The invention relates to the technical field of sympathetic nervous excitement detection, in particular to a sympathetic nervous excitement intelligent detection system and a wearable detection neck ring. A bio-electricity signal acquisition module is provided with a plurality of electrodes for acquiring original bio-electricity signals; the signal processing module is used for extracting a specific frequency band signal related to sympathetic nerve activity as a neck electroneurogram signal; extracting time domain features and nonlinear dynamic features; performing multi-feature fusion according to the time domain features and the nonlinear dynamic features to generate primary index data of the sympathetic nerve excitement degree of the user; and the communication module is used for sending the sympathetic nerve excitement primary index data to an external terminal and fusing to generate comprehensive sympathetic nerve excitement data. The technical problem that in the prior art, effective measurement and recognition are difficult in the mode that sympathetic nervous excitement measurement is carried out by adopting a neck myoelectricity measurement mode is solved.

The invention provides an emotion awakening degree decoding method and system, and relates to the field of emotion calculation, and the method comprises the steps: collecting a skin electric signal under emotion stimulation; the skin electric signals are preprocessed; the preprocessed skin electric signals are processed through a sympathetic nerve inversion network, and a network inversion value representing the sympathetic nerve activation level is obtained; the network inversion value is subjected to inverse mapping through an emotional wakeup degree inverse mapping network, a predicted value of the emotional wakeup degree is obtained, the sympathetic nerve inversion network and the emotional wakeup degree inverse mapping network form an end-to-end emotional wakeup degree decoding model, and a loss function of the emotional wakeup degree decoding model comprises the weighted sum of physiological loss and psychological loss. The physiological loss is used for calculating the difference between the network inversion value of the sympathetic nerve activation level and the theoretical inversion value, and the psychological loss is used for calculating the difference between the predicted value and the label value. According to the method, the problem of inaccurate emotion awakening degree calculation is solved.

The invention relates to the technical field of biomedical engineering, and discloses a renal sympathetic nerve nuclide evaluation system and method for RDN, and the system comprises a nuclide image collection module, a data analysis module, a nuclide kinetic parameter analysis module, a neural activity quantification module and a dynamic evaluation and decision module, and is used for collecting a nuclide image data set; identifying a kidney area in the nuclide image data set, and analyzing the radioactivity counting rate of the kidney area; analyzing an uptake index and a retention index of the radionuclide marker based on the radioactivity counting rate; analyzing a sympathetic nerve activity quantitative index of the kidney region according to the uptake index, the retention index and the electrocardio physiological data; and determining a dynamic threshold value of the sympathetic nerve activity quantitative index based on the activity expression level index of the target object, and performing dynamic analysis on the sympathetic nerve activity quantitative index according to the dynamic threshold value to obtain an evaluation index. According to the invention, the accuracy of kidney sympathetic nerve nuclide evaluation can be improved.

A therapy device includes a device body housing a stimulation component so as to position the stimulation component at or near an anatomical region of a user. An actuator under control of a control unit causes the stimulation component to therapeutically stimulate, via the anatomical region of the user, the sympathetic nerve chain at the Morgan Point adjacent the styloid process of the user.

The application discloses a kind of 18 F-MFPBG automatic marking method and purpose, it relates to the field of radiopharmaceutical chemistry, the marking method is sequentially executed by automatic synthesis system 18 F ion enrichment elution, nucleophilic substitution reaction with precursor MFPBG, preliminary purification, acid hydrolysis, preparative high performance liquid chromatography separation and purification and final sterile injection preparation etc. Step, realizes the automation and standardization of marking process. The application also provides 18 The use of F-MFPBG for preparing myocardial sympathetic nerve imaging agent, which is suitable for the diagnosis, prognosis evaluation or treatment effect monitoring of coronary heart disease, arrhythmia or heart failure. The imaging agent prepared by the method of the application has the advantages of suitable half-life, high labeling efficiency and stable product quality, providing a reliable tool for in vivo quantitative evaluation of cardiac sympathetic nerve function.