The invention discloses a pressure measurement noninvasive anti-blocking urine guiding device. The pressure measurement noninvasive anti-blocking urine guiding device comprises a catheter, a bladder pressure measurement module, an internal urethral orifice blocking module, a noninvasive air sac module, a diluted liquid injection module, a sterilization module, a urine storage module and an anti-blocking urine guiding module. The pressure measurement noninvasive anti-blocking urine guiding device is delicate and reasonable in structural design, utilizes the negative pressure suction principle, can still drain urine when a few blood clots and other foreign materials are generated inside the bladder, effectively guarantees the urine guiding and drainage effects, and enables a user to visually know the condition of the pressure inside the bladder through the bladder pressure measurement module and know the urine guiding and drainage effects and the circulation condition of a drainage passage in real time when indwelled in a urethral catheter. The noninvasive air sac module wraps the catheter, can achieve the function of negative pressure suction, and can relieve the pain in urethral catheterization. The sterilization module can sterilize the indwelled catheter for long time, largely reduces the occurrence rate of infection caused by the indwelled catheter, guarantees use safety, prolongs the effective indwelling time, reduces the frequency of replacing the urethral catheter, largely saves medical cost and relieves the pain of patients.