818 results about "Wound surface" patented technology

The invention provides a wound surface grading model construction method and a wound surface self-analysis system, and the method comprises the steps: processing an obtained wound surface image, clinical text description data and structured background information data through a specific feature extraction strategy, and obtaining an image feature vector; clinical text description data and structured background information data are subjected to cleaning, word segmentation, entity labeling and other operations, a wound semantic evolution graph is constructed, related vectors are fused to obtain text embedding, wound background context vectors are generated according to the structured background information data, dynamic weighting, splicing and fusion are performed on image and text feature vectors, and the image and the text feature vectors are subjected to image fusion. According to the method, the fusion feature vector is obtained, the corresponding grading model is constructed according to the fusion feature vector, more accurate, comprehensive and explainable grading evaluation can be performed on different types of wounds, and a self-analysis system designed for the constructed model can quickly and accurately judge the wound image condition shot by a user.

The invention relates to the technical field of burn wound treatment, and discloses an intelligent burn wound dynamic monitoring and evaluation system. The system comprises a data acquisition module for acquiring real-time physiological data of a burn wound by using a multi-source sensor; the multi-modal feature fusion module is used for generating wound comprehensive state features based on a deep belief network; the dynamic evaluation module outputs a wound healing level and a risk early warning signal through a pre-trained collaborative evaluation model; the optimization decision generation module is used for constructing a multi-target dynamic optimization model to adjust a treatment scheme according to risk early warning; and the hierarchical execution control module realizes distributed execution of treatment instructions through a hierarchical control architecture. The system can comprehensively monitor the state of the wound surface, accurately evaluate the healing risk, optimize the treatment scheme and accurately execute the treatment scheme, effectively improve the treatment effect of the burn wound surface, reduce the infection risk and shorten the healing period, and has important clinical application value.

The invention provides a combined debridement nursing device for an operating room, and belongs to the technical field of debridement devices. Comprising a flushing handle, one end of the flushing handle is fixedly connected with a flushing assembly, the flushing assembly is used for assisting in wound cleaning, and the flushing assembly is connected with the flushing handle; and the suction assembly is used for extracting liquid and foreign matters in the wound, and the suction assembly is connected with the flushing assembly. By arranging the flushing assembly and the suction assembly, the flushing assembly and the suction assembly are arranged on the flushing gun and the suction pipe correspondingly, the flushing assembly can avoid direct contact between a flushing head and a wound surface and improve the debridement efficiency, necrotic tissue can be conveniently removed in the debridement process, and therefore the flushing head can treat the wound surface more conveniently; the suction assembly can be used in combination with the flushing gun and can be independently used, blockage can be effectively prevented, and the debridement efficiency is improved.

The invention belongs to the technical field of battery dressings, and particularly relates to a wearable magnesium battery self-powered dressing for chronic wound healing and a preparation method and application thereof. A flexible conductive carbon cloth coated with a viologen-based covalent organic framework material is used as a battery positive electrode, a magnesium sheet is used as a negative electrode, polyacrylamide hydrogel is used as a solid electrolyte, and the flexible wearable self-powered dressing is assembled. The formed electrode can effectively input electrical stimulation to the wound surface, the dressing can simulate an endogenous electric field in the wound, induce migration of fibroblasts, regulate the immune microenvironment of the wound and inhibit inflammatory response, polyacrylamide is used as gel electrolyte, and the dressing has good hygroscopicity, can absorb exudate at the wound surface and keep a wet healing environment, and can be applied to the wound healing. The chronic wound healing of the rat is effectively promoted. The self-powered dressing prepared by the invention provides a reliable electrotherapy method for chronic wound healing.

The invention discloses a high-activity injectable self-healing temperature-sensitive hydrogel dressing and a preparation method and application thereof, the high-activity injectable self-healing temperature-sensitive hydrogel dressing is obtained by forming a temperature-sensitive hydrogel through a two-dimensional nano material MXene aqueous solution and F127 under the hydrogen-bond interaction, combining an M2 macrophage source exosome on MXene under the electrostatic adsorption action, and wrapping the MXene through a network structure of the hydrogel. The preparation method is simple, an obtained sample is free of organic solution residues, reaction conditions are mild, operation is convenient, the raw material cost is low, the hydrogel dressing has temperature-sensitive, injectable and self-healing performance, the hydrogel dressing has temperature-sensitive and injectable performance, is sol at normal temperature, forms gel after making contact with skin and is convenient to smear and use on wounds, and experimental results prove that the hydrogel dressing has good application prospects. The hydrogel has good biocompatibility and relatively strong antibacterial performance, and can effectively play anti-inflammatory and vascular regeneration promoting roles in diabetic wounds and promote rapid repair of the diabetic wounds.

The invention relates to a wound surface mixed bacteria unmixing method and system based on a double-branch attention mechanism, and belongs to the technical field of biomedical engineering and image processing. The method comprises the following steps: S1, acquiring hyperspectral images of a single strain culture dish, a blank culture dish and a mixed strain wound sample; s2, performing data extraction and preprocessing on the sample hyperspectral image, enhancing the data based on a spectral linear hybrid model and an adversarial generative network, and generating and synthesizing mixed bacteria hyperspectral data; s3, constructing a mixed bacteria unmixing model based on a space-spectrum double-branch attention mechanism; s4, inputting the synthesized mixed bacteria spectrum data into a mixed bacteria unmixing model for training, and optimizing parameters of the model according to the minimum total loss function of the model; and S5, inputting the hyperspectral data of the mixed bacteria wound sample to be unmixed into the trained mixed bacteria unmixing model, and outputting the unmixing abundance of the sample and the corresponding end metainformation.

The invention discloses a preparation method and application of a double-layer sound transmission type berberine-loaded gelatin microsphere slow-release antibacterial gel dressing, and belongs to the technical field of gel dressings. The preparation method comprises the following steps: taking vinyl silicone oil and silicon dioxide as raw materials, preparing upper-layer silica gel by adopting a double-component uniform mixing method, and then laminating the upper-layer silica gel and lower-layer berberine-loaded gelatin microsphere hydrogel by adopting a self-laminating method, thereby obtaining the double-layer sound-transmission type berberine-loaded gelatin microsphere slow-release antibacterial gel dressing. By means of the broad-spectrum antibacterial function of berberine, the efficient drug loading function and slow drug release function of gelatin microspheres, the sound transmission and swelling functions of lower hydrogel and the supporting function of upper hydrogel, ultrasonic inspection is conducted through a dressing covering layer, an ultrasonic scanning supporting plane is provided, ultrasonic waves penetrate through the dressing, good imaging is formed, and the application prospect is wide. And antibacterial and repairing effects on local wounds are realized at the same time.

The invention discloses a COF electrostatic spinning wound dressing with near-infrared response and antioxidant activity and a preparation method of the COF electrostatic spinning wound dressing, and belongs to the field of application materials and technologies. The COFs are synthesized from cobalt hexafluorophthalocyanine (CoPcF16) and ellagic acid (EA). The COFs is prepared into the spinning membrane, and the COFs spinning membrane has very strong oxidation resistance, can effectively remove excessive endogenous ROS, can respond to near infrared to generate exogenous ROS, and can effectively kill bacteria at a wound and improve blood flow and healing of the wound. The COFs spinning membrane prepared by the invention is simple and convenient in preparation method, good in biocompatibility, strong in oxidation resistance and capable of responding to near infrared to produce ROS, and has strong application potential in the field of treatment of a series of infected wounds, especially treatment of diabetic foot ulcers.

The invention discloses a negative pressure drug delivery dynamic adjusting device for a wound surface and a using method thereof, and relates to the technical field of medical instruments and equipment.The negative pressure drug delivery dynamic adjusting device comprises a machine shell, a control module, a connecting module, a negative pressure module and a drug delivery module in the wound surface are installed in the machine shell, a collecting chamber is arranged on one side of the bottom of the machine shell, and a pressure stabilizing linkage control mechanism is further arranged in the machine shell; the pressure stabilization linkage control mechanism is used for dynamic regulation and control of negative pressure and drug administration in the wound surface; the connecting module is used for uniform negative pressure of the wound surface and drug administration in the wound surface; according to the scheme, multi-mode free combination is adopted, single negative pressure / in-wound drug delivery, synchronous linkage, reverse linkage and an alternating mode are supported, the full-period requirement from acute trauma to chronic repair is met, and intelligent parameter matching is conducted, for example, through pressure-flow closed-loop feedback, when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced, and when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced; when wound exudate is reduced, pulse negative pressure is triggered to promote microcirculation.

The invention belongs to the technical field of biological materials, and particularly relates to nano composite hydrogel as well as a preparation method and application thereof. In the preparation process of the hydrogel, preparation of gelatin hydrazide and preparation of pullulan oxidation are sequentially completed, then preparation of active component loaded PLGA nanoparticles and self-assembly coating with metal-polyphenol are completed, and finally, the metal-polyphenol coated PLGA nanoparticles are mixed with gelatin hydrazide and pullulan oxidation to form gel in situ. The hydrogel has the characteristics of injectability, self-healing, wet adhesion and the like, the metal-polyphenol layer has the effects of resisting inflammation, resisting oxidation and promoting angiogenesis and generates photo-thermal response to near infrared rays, on-demand controllable release of the drug-loaded nanoparticles is achieved, the composite hydrogel can improve the wound surface microenvironment, promote angiogenesis and inhibit inflammation and scar formation, and the drug-loaded nanoparticles can be applied to wound healing. The ointment is suitable for burns, scalds and various complex wounds.

The plugging drainage device comprises an outer sleeve, a flushing pipe, an inner suction pipe and an umbrella-shaped plugging mechanism, a plurality of first through holes are formed in the front end of the outer sleeve, the inner suction pipe is arranged in the outer sleeve, a plurality of second through holes are formed in the front end of the inner suction pipe, and the umbrella-shaped plugging mechanism is arranged in the inner suction pipe. The umbrella-shaped plugging mechanism is arranged at the front end of the outer sleeve and can be retracted into the outer sleeve. The device is provided with the plugging mechanism, the fistula can be plugged during flushing, intestinal juice loss is effectively avoided, postoperative recovery of a patient is facilitated, the umbrella-shaped structure is adopted for plugging, compared with bag plugging, the umbrella fabric of the umbrella-shaped structure can be tightly attached to the wound surface, obstruction is effectively avoided, and the application safety of the device is further improved.

The invention discloses a bi-crosslinking gelatin-based hydrogel wound dressing as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method disclosed by the invention comprises the following steps: mixing a gelatin solution and an oxidized konjac glucomannan solution, heating and stirring to obtain a hydrogel precursor solution; and mixing the hydrogel precursor solution with a borax solution to obtain the bi-crosslinked gelatin-based hydrogel wound dressing. According to the method, oxidized konjac glucomannan and gelatin are subjected to Schiff base and Schiff base crosslinking, borax is further added to introduce a dynamic boric acid ester bond effect to enhance a three-dimensional network of the hydrogel, and the dynamic reversible Schiff base effect and the boric acid ester bond effect are enhanced, so that the pore diameter and the swelling ratio of the hydrogel are increased, and the gel strength of the hydrogel is enhanced; due to the good self-healing injectable performance, biodegradability and mechanical property of the hydrogel, the hydrogel can be used as a wound dressing for irregular deep skin wounds, and the technical problem that existing hydrogel is insufficient in treatment of irregular wounds is solved.

The invention relates to an intelligent dynamic negative pressure and phototherapy integrated burn wound treatment device, and belongs to the technical field of medical instruments, the device comprises a contact layer, a conduction layer and a honeycomb support layer, the contact layer drains exudate, the conduction layer is integrated with an optical fiber network and a self-adaptive deformation mechanism, and the honeycomb support layer is connected with an intelligent negative pressure chamber and a gradient sterilization system. The pressure of the negative pressure chamber is dynamically adjusted through a corrugated air bag and a rhombic telescopic unit, and the photo-thermal assembly irradiates the wound surface in a time-sharing mode and maintains the constant temperature. And the sterilization system adopts ultraviolet pulse and a multi-stage filter screen to cooperatively purify the percolate. The intelligent regulation and control module optimizes treatment parameters in real time through a multi-mode sensing network, and full-closed-loop cooperation of negative pressure, phototherapy and sterilization is achieved. According to the device, the limitation of traditional treatment is broken through through integrated design, the wound repairing quality and the anti-infection capacity are remarkably improved, meanwhile, the medical care burden is reduced through modular expansion and a non-invasive monitoring function, and an efficient and safe intelligent solution is provided for burn management.

The invention provides a wound exudate amount type determination method. The method comprises the following steps: acquiring wound humidity data at a plurality of moments; performing curve fitting on the wound surface humidity data based on a first-order system model, and determining a system gain and a time constant of the first-order system model; based on the system gain and the time constant, a corresponding wound surface seepage amount type is determined through a pre-established dichotomy model, and the dichotomy model is established based on pre-provided wound case data. In addition, the invention further relates to a wound surface seepage amount type determining device applying the wound surface seepage amount type determining method, and further relates to a wound surface humidity monitoring device and a wound surface humidity monitoring system comprising the wound surface seepage amount type determining device.

The invention discloses a gel dressing for treating haemorrhoids and a preparation method of the gel dressing. The gel dressing is prepared from the following raw materials in parts by weight: modified chitosan, multifunctional lipidosome, fructo-oligosaccharide, hyaluronic acid, carbomer, glycerol and recombinant human epidermal growth factors. Chitosan has good film-forming property and antibacterial activity, when haemorrhoids are cracked and bleeding due to long-term constipation, a wound surface is in a high-pH and high-ROS environment, the modified chitosan forms a compact protective film on the ulcerated wound surface, the multifunctional lipidosome with contracted film holes and larger particle size is blocked outside, heparin molecules are grafted on the modified chitosan, and the heparin molecules are grafted on the surface of the wound surface. Recombinant human epidermal growth factors are allowed to pass through, and wound healing is accelerated. When the ulceration part is gradually healed, the pH and ROS level return to normal, the protective film of the modified chitosan is expanded, and the multifunctional liposome is diffused and degraded through the protective film to release the pepper extract, the borneol and the menthol. Fructo-oligosaccharide is added to maintain normal flora balance in the anorectum area.

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

The invention discloses a preparation method and application of autologous fibrin glue, and belongs to the field of biomedical materials. The preparation method comprises the following five steps: collecting autologous venous blood, adding a sodium citrate anticoagulant with the volume ratio of 1: (8-12), and storing at 4-6 DEG C for not more than 2 hours; performing step-by-step centrifugation at the speed of 1500 to 2000 r / min and the speed of 3500 to 4000 r / min to obtain a fibrinogen concentrate; the thrombin-calcium chloride activation solution A and the tranexamic acid activation solution B are mixed according to the ratio of 1: (2-3) to form a composite activation system; mixing the two components according to a mass ratio of 1: (0.8-1.2), and reacting at 25-37 DEG C for 3-5 minutes to form colloid; and pre-freezing at-40 to-60 DEG C, performing vacuum freeze-drying, and storing at 4-8 DEG C. During application, the colloid can be coated on an operation wound surface after being redissolved, or mixed with a growth factor to prepare a dressing for covering a chronic wound surface. The colloid is high in purity, stable in coagulation time, long in storage period, suitable for scenes such as surgical hemostasis and the like, and high in clinical value.

The embodiment of the invention provides a melanoma postoperative wound intelligent dressing, and belongs to the technical field of intelligent medical treatment. The intelligent dressing for the wound after the melanoma operation comprises a multiple monitoring module, an intelligent processing module and an on-demand drug delivery module which are arranged on a dressing base body, the multiple monitoring module is used for acquiring biological signals of a wound surface microenvironment in real time; and the intelligent processing unit analyzes the biological signal to generate a wound state judgment result, and controls the on-demand drug delivery module to trigger electrical stimulation or thermal stimulation based on the wound state judgment result so as to realize on-demand drug release. According to the scheme, the deep learning intelligent early warning model fusing the generative adversarial network and the Transform structure is constructed, high-precision analysis and dynamic risk judgment of melanoma postoperative wound multi-dimensional time sequence data are achieved, and the accuracy and stability of wound state recognition are effectively improved.

The invention relates to the technical field of medical detection and spectral analysis, and discloses a spectrum detection method for microorganisms on a wound surface based on knowledge data dual-drive envelope fusion. The method comprises the following steps: firstly, acquiring a multi-band near-infrared spectrum signal of a wound surface through a fiber optic spectrometer, and carrying out normalization and smooth filtering pretreatment; analyzing optical characteristic parameters based on a diffuse reflection theory model, constructing a knowledge-driven characteristic sample space, extracting spectral high-order characteristics by using a one-dimensional deep convolutional neural network, and constructing a data-driven characteristic sample space; then generating a grain envelope sample through a double-flow feature fusion mechanism; and finally, constructing a lightweight dual-task classification model based on the particle envelope sample, and realizing rapid detection of fungal infection of the wound surface and identification of seven common bacteria. According to the method, the interpretability, the recognition precision and the robustness of characteristic pathology are considered, and an efficient and reliable technical scheme is provided for early clinical diagnosis of wound infection.

The invention relates to the technical field of biomedicine, and provides an endometrial repair stent and a preparation method thereof.The endometrial repair stent is prepared by taking a flaky nanofiber composite membrane as a substrate, combining the flaky nanofiber composite membrane with modified hyaluronic acid, then conducting dynamic crosslinking with carboxymethyl chitosan and then conducting compounding with poly N-isopropylacrylamide; the mass ratio of the modified hyaluronic acid to the carboxymethyl chitosan to the poly (N-isopropylacrylamide) is (1-9): (1-9): (1-90); the thickness of the nanofiber composite membrane is 0.1-0.4 mm, and the nanofiber composite membrane can be applied to treatment of intrauterine adhesion. According to the endometrial repair stent, the nanofiber composite membrane and the temperature-sensitive hydrogel are combined, a uterine cavity is fully paved by utilizing the fluidity of the hydrogel, and the three-dimensional structure of the nanofiber can be used for orderly inducing a wound surface, so that the adhesion and proliferation of cells are facilitated, scar formation is reduced, the repair effect is ensured, and regeneration is promoted. The two parts are combined, so that the plasticity of the whole structure is enhanced, the supporting performance is improved, the indwelling time in the uterine cavity is long, and the double effects of repairing and isolating are fully achieved.

The invention provides a wound cleaning and disinfecting integrated device, and relates to the technical field of medical care equipment. The device integrates cleaning, disinfection and intelligent control functions, and solves the problems that traditional wound surface treatment equipment is inconvenient to operate, uneven in cleaning and disinfection effects and the like. The device comprises key components such as a main body part, a sterilizing lamp, an ozone generator, a cleaning and sterilizing interface, a flexible telescopic pipe, a spray head, a draw-off pump, a cleaning liquid and sterilizing liquid storage tank, a temperature sensor and the like. By automatically spraying the cleaning liquid and the disinfectant and combining ozone and ultraviolet ray disinfection, the wound surface is ensured to be thoroughly cleaned and disinfected. The controller has the functions of display, voice interaction, remote monitoring and the like, and the operation convenience and safety are improved. The design of a push handle connecting rod and universal wheels enables the device to move flexibly and is suitable for various treatment scenes. And a built-in storage battery provides power support, so that normal operation of the equipment in a power-free environment is ensured.

The invention relates to the technical field of drug-loaded microparticles, in particular to a preparation method and application of medical stone / PLGA composite drug-loaded microparticles, medical stone and PLGA are prepared into a structure with activated nano medical stone as a core and a PLGA polymer as a shell through the processes of ball milling, acid activation, emulsification, solvent volatilization and the like, and the medical stone and the PLGA are synergistically matched, so that the drug-loaded microparticles have the advantages that the drug-loaded microparticles are uniform in particle size distribution, and the drug-loaded microparticles have good drug-loaded performance. Firstly, the hydrogel has intelligent responsiveness, can accelerate degradation in alkaline and enzyme environments of wound surfaces, and realizes accurate release of drugs as required; secondly, the long-acting controlled release property is shown, and a dual sustained release barrier is constructed through medical stone adsorption and PLGA wrapping, so that the medicine is released for more than 72 hours at a constant speed following zero-order dynamics, and burst release is effectively avoided. And thirdly, when the drug-loaded particles are used for hydrogel, the drug-loaded particles in nanoscale are combined with the hydration effect of a hydrogel matrix, so that the efficient permeability of the drug in the cuticle is greatly improved.

The invention relates to the technical field of biomedical materials, in particular to a microneedle patch for diabetes wound healing and a preparation method and application thereof. The microneedle patch comprises a substrate and a microneedle array arranged on the surface of the substrate, the substrate is prepared from a first raw material system comprising polyvinyl alcohol, phenylboronic acid modified oxidized hyaluronic acid, bromothymol blue and first drug micromolecules; the microneedle array is prepared from a second raw material system which comprises methylacryloylated gelatin, 2-(methylacryloyloxy) ethyl choline phosphate and platelet cell membrane wrapped MOF loaded second drug micromolecules. The microneedle patch has the characteristics of promoting angiogenesis, being excellent in antibacterial property and slow release, also has sensitive pH responsiveness and ROS responsiveness at the same time, can adjust the release dose of the medicine according to the wound surface microenvironment change (pH value change and ROS concentration change), can monitor the wound surface state in real time according to the wound surface pH value change indication, and is suitable for being popularized and used clinically.

The invention discloses a temperature-controlled anti-inflammatory and antibacterial skin wound dressing capable of promoting revascularization and a preparation method and application thereof, and relates to the technical field of medical materials, the preparation method comprises the following steps: S1, preparing calcium peroxide microspheres; s2, the poloxamer 407, the chitosan and the forsythiaside A are jointly dissolved in an acetic acid solution, and mixed gel is obtained; s3, dispersing calcium peroxide microspheres into the mixed gel to obtain the skin wound dressing capable of controlling temperature, resisting inflammation and bacteria and promoting revascularization. The traditional Chinese medicine active ingredient forsythiaside A is loaded, so that the healing efficiency of diabetic wounds is improved; due to the temperature-sensitive property of the gel, the gel can be better attached to the wound, the antibacterial property can inhibit microorganism breeding at the wound surface, the oxygen release capacity can improve the anoxic environment at the wound, and the loaded traditional Chinese medicine active ingredient forsythiaside A has the anti-inflammatory capacity, promotes cell regeneration at the wound and accelerates the repair process.

The invention relates to the field of medical instruments, and discloses a water pumping mixing type pancreatic cancer postoperative drainage device which comprises a negative pressure pump cabin, a liquid inlet and a liquid outlet are formed in the negative pressure pump cabin, the liquid inlet is communicated with a water inlet pipe and a first drainage pipe, the liquid outlet is communicated with a second drainage pipe, the end of the water inlet pipe is connected with a water supply tank, and the end of the second drainage pipe is connected with a liquid storage tank. A first overflowing cabin and a second overflowing cabin are formed in the negative pressure pump cabin, a first pipe cabin and a second pipe cabin are arranged between the first overflowing cabin and the second overflowing cabin in a communicating mode, and one-way valve structures are arranged at the connecting positions of the first overflowing cabin and the first pipe cabin and the connecting positions of the second overflowing cabin and the second pipe cabin. According to the device, the first drainage tube is placed in a wound surface, negative pressure is generated in the negative pressure pump cabin, the hydrops enters the liquid inlet along the first drainage tube under the action of the negative pressure and is mixed with water at the liquid inlet, the concentration and viscosity of the hydrops are reduced after the hydrops and the water are mixed, the situation that the hydrops are blocked in a pipeline due to high viscosity is reduced, and the anti-blocking effect is improved.

The invention provides a programmable hydrogel wound dressing with rotation contraction force and application thereof, and belongs to the technical field of biomedical materials, the programmable hydrogel wound dressing comprises a dual-network hydrogel main body, a first hydrogel layer, a second hydrogel layer, a first hydrogel layer and a second hydrogel layer, and the dual-network hydrogel main body is composed of a first network and a second network; the first network is a chemically cross-linked methacrylated hyaluronic acid network and forms a cross-linked network structure through photopolymerization; the second network is a physical cross-linked polyvinyl alcohol network, and forms an instantaneous cross-linking point with a crystal region through a hydrogen bond, so that the hydrogel is endowed with shape memory performance; the surface is modified with an N-hydroxysuccinimide ester functional group, and the N-hydroxysuccinimide ester functional group and amino of wound tissue protein can form a covalent bond; the dual-network hydrogel main body is subjected to pre-stretching or pre-twisting treatment and then is dried and shaped into a preset shape, the initial shape is recovered after moisture is absorbed, and rotary contraction mechanical force is output. Rapid wound healing and scar-free regeneration are achieved by dynamically regulating and controlling wound edge mechanical force and enhancing tissue adhesion, and then application to regulation and control of wound microenvironment to promote scar-free healing is achieved.

The invention relates to the technical field of intelligent diagnosis, in particular to an intelligent wound assessment management system and method for large-area burn, and the system comprises an exudation associated region extraction module, a structural stress concentration recognition module, a tissue boundary disturbance recognition module, an adhesion imbalance path calibration module and a wound assessment management output module. According to the method, the correlation between the edge trend of the exudation area and the texture extension direction is extracted, the longitudinal contact track of the middle-layer tissue boundary in the image sequence is combined, the angle change process of the slippage trend and the local direction information is iteratively identified, and the continuous change of the path offset behavior in the time range is tracked; and extracting spatial distribution of structure response features in a layer region, a correlation tension direction, boundary movement and an exudation trend, completing layer output of region state difference, expanding a space-time correlation range of path change and region difference in an image sequence, and enhancing a linkage capability of a structure path and a tissue state under a continuous image.

The utility model discloses a postoperative wound protection device for thoracic surgery, which relates to the technical field of postoperative care and comprises gauze, a gasket is fixedly connected outside the gauze, the left side and the right side of the gasket are respectively and fixedly connected with a side belt, and a movable component convenient for changing medicine is arranged inside the gauze. According to the wound protection device used after the thoracic surgery, the groove, the movable piece, the movable head, the inner plate, the mucilage glue, the medicine cloth and the fixed head are arranged, the position of the gasket is aligned to the outer portion of the wound position after the thoracic shell operation of a patient, the gauze covers the surface of the wound, and when dressing change is needed, the fixed head is opened, the movable piece is opened at the front end of the groove, and then the dressing change is completed. Meanwhile, a plurality of groups of mucilage glue are arranged on the inner plate, close to the wound surface, of the movable piece, so that the medicine cloth is fixed on the inner plate through the mucilage glue, when the medicine cloth needs to be replaced, the medicine cloth is directly torn off at the mucilage glue position and then is covered again, and the problem that the device does not have the function of facilitating medicine changing is solved.

The invention belongs to the technical field of photoacoustic response antibacterial dressings, and discloses PDA (at) Ag (at) Ag2S / SA / F68 / F127 antibacterial temperature-sensitive hydrogel as well as a preparation method and application thereof.The PDA (at) Ag (at) Ag2S / SA / F68 / F127 antibacterial temperature-sensitive hydrogel can complete conversion of gel and sol under the condition of 4-60 DEG C, PDA (at) Ag (at) Ag2S nano-enzyme is constructed by means of an in-situ growth method, a PDA (at) Ag (at) Ag2S nano-composite material can generate electron-hole pairs under photoacoustic combination, then reactive oxygen species (ROS) is generated, and the antibacterial temperature-sensitive hydrogel can be used for preparing antibacterial temperature-sensitive hydrogel. The photoacoustic response antibacterial effect is realized. Meanwhile, PDA (at) Ag (at) Ag2S has peroxidase (POD)-like activity, and the material can catalyze endogenous hydrogen peroxide (H2O2) in a common wound microenvironment with the pH value of 7-8 to generate reactive oxygen species (ROS) with high toxicity, such as hydroxyl free radicals (. OH), so that efficient killing of various bacteria under photoacoustic combination is realized. Synthesis conditions are mild, and the process is simple, economical and feasible. The hydrogel has thermosensitivity, can resist inflammation, stop bleeding and relieve wound pain, does not loosen after absorbing seepage, is free of residues and does not adhere to a wound surface when being removed, and a new way is provided for developing novel medical dressings for treating drug-resistant bacterial infection wounds.

The present disclosure discloses a skin and soft tissue external expansion device, comprising: a decompression device which is fixed on the skin at the edge of the first side of the wound surface by a single continuous flexible wire and is in an elongated shape, the flexible wire is arranged in a U shape, and the bottom of the U shape abuts against the side wall of the decompression device; and a wire winding device which is fixed on the skin at the edge of the second side of the wound surface opposite to the first side by the flexible wire and is connected to the decompression device through the flexible wire, the wire winding device includes a wire winder sleeve placed on the edge skin and a wire winder received in the wire winder sleeve, the wire winder includes a wire head fixing part and a wire winding part connected to each other, the wire head fixing part is configured to fix the two protruding segments of the U shape of the flexible wire, and the wire winding part is configured to wind the flexible wire between the decompression device and the wire head fixing part to control the length of the flexible wire between the decompression device and the wire winding device. The skin and soft tissue external expansion device of the present disclosure is easy to use and has a wide range of applicable parts.