1060 results about "Wound surface" patented technology

The invention relates to the technical field of medical instruments, and provides a vacuum sealing drainage dressing and a wound surface treatment device.The vacuum sealing drainage dressing comprises a sealing layer and a dressing layer which are sequentially arranged in a stacked mode from top to bottom, and further comprises a drainage assembly; the drainage assembly comprises a sucker and a drainage tube, the sucker is arranged at the adsorption opening of the sealing layer, and the drainage tube is connected to the sucker; the dressing layer is of a porous structure, hole walls are communicated with one another to form a continuous channel, the dressing layer is provided with a flexible plasma patch, the flexible plasma patch is suitable for generating plasma acting on a wound surface, and the flexible plasma patch is provided with through holes communicated with pores. The flexible plasma patch is integrally arranged on the dressing layer, negative pressure drainage and wound sterilization and disinfection combined healing promoting treatment can be achieved, the wound or wound treatment process can be simplified, inconvenience caused by frequent dressing change is reduced, and the faster and better healing effect is achieved.

The invention provides a wound surface grading model construction method and a wound surface self-analysis system, and the method comprises the steps: processing an obtained wound surface image, clinical text description data and structured background information data through a specific feature extraction strategy, and obtaining an image feature vector; clinical text description data and structured background information data are subjected to cleaning, word segmentation, entity labeling and other operations, a wound semantic evolution graph is constructed, related vectors are fused to obtain text embedding, wound background context vectors are generated according to the structured background information data, dynamic weighting, splicing and fusion are performed on image and text feature vectors, and the image and the text feature vectors are subjected to image fusion. According to the method, the fusion feature vector is obtained, the corresponding grading model is constructed according to the fusion feature vector, more accurate, comprehensive and explainable grading evaluation can be performed on different types of wounds, and a self-analysis system designed for the constructed model can quickly and accurately judge the wound image condition shot by a user.

The invention relates to the technical field of burn wound treatment, and discloses an intelligent burn wound dynamic monitoring and evaluation system. The system comprises a data acquisition module for acquiring real-time physiological data of a burn wound by using a multi-source sensor; the multi-modal feature fusion module is used for generating wound comprehensive state features based on a deep belief network; the dynamic evaluation module outputs a wound healing level and a risk early warning signal through a pre-trained collaborative evaluation model; the optimization decision generation module is used for constructing a multi-target dynamic optimization model to adjust a treatment scheme according to risk early warning; and the hierarchical execution control module realizes distributed execution of treatment instructions through a hierarchical control architecture. The system can comprehensively monitor the state of the wound surface, accurately evaluate the healing risk, optimize the treatment scheme and accurately execute the treatment scheme, effectively improve the treatment effect of the burn wound surface, reduce the infection risk and shorten the healing period, and has important clinical application value.

On one hand, the invention relates to a sulfur-selenium doped carbon dot and Halicin synergistic antibacterial material which is prepared from an S, Se-CQDs solution and a Halicin solution in parts by weight as follows: 50-120 parts of the S, Se-CQDs solution, 0.1-0.3 parts of an EDC chemical reagent, 0.1-0.3 parts of an NHS chemical reagent, 125-300 parts of the Halicin solution and 12-35 parts of a NaOH solution, and on the other hand, the invention relates to a preparation method of the sulfur-selenium doped carbon dot and Halicin synergistic antibacterial material. The characteristics that the sulfur-selenium-doped carbon dots are uniform in size and easy to enter cells are utilized, the sulfur-selenium-doped carbon dots can cooperate with the Halicin to enter the cells to destroy the flow of protons on cell membranes, so that the sterilization and antibacterial effects are achieved, the sulfur-selenium-doped carbon dots and the Halicin synergistic antibacterial material can form a hydration layer on the surface of a wound by utilizing the oxidation resistance of the sulfur-selenium-doped carbon dots, and the antibacterial effect of the wound is improved. The adhesion of bacteria is prevented, so that the antibacterial effect is enhanced.

The invention provides a fiber dressing for promoting wound healing and a preparation method and application thereof, and belongs to the technical field of biological materials. The shell of the fiber dressing contains the first medicine for promoting polarization of macrophages, and the first medicine can promote polarization of macrophages at normal and diabetic wound surfaces from M1 type to M2 type; a shell substrate is a mixture of hydrophilic and hydrophobic polymers, so that painless adhesion and stripping of a wound surface can be realized by absorbing seepage and spraying non-irritant normal saline on the wound surface, and secondary injury of the wound surface is reduced; an inner core contains a second medicine and a third medicine which are used for inducing death of M1 type macrophages, so that wound inflammatory response can be reduced, wound bacteria can be killed, wound infection degree can be reduced, and wound healing can be accelerated; the core matrix is a mixture of hydrophilic and hydrophobic polymers with good biocompatibility, can provide mechanical support for the fiber dressing, and provides a slow release effect for the two substances in the core. By controlling the composition of the inner core and the shell, the healing of normal wounds and diabetic wounds can be effectively promoted.

The invention provides a combined debridement nursing device for an operating room, and belongs to the technical field of debridement devices. Comprising a flushing handle, one end of the flushing handle is fixedly connected with a flushing assembly, the flushing assembly is used for assisting in wound cleaning, and the flushing assembly is connected with the flushing handle; and the suction assembly is used for extracting liquid and foreign matters in the wound, and the suction assembly is connected with the flushing assembly. By arranging the flushing assembly and the suction assembly, the flushing assembly and the suction assembly are arranged on the flushing gun and the suction pipe correspondingly, the flushing assembly can avoid direct contact between a flushing head and a wound surface and improve the debridement efficiency, necrotic tissue can be conveniently removed in the debridement process, and therefore the flushing head can treat the wound surface more conveniently; the suction assembly can be used in combination with the flushing gun and can be independently used, blockage can be effectively prevented, and the debridement efficiency is improved.

The invention relates to digestive tract mucosa protective agent powder as well as a preparation method and application thereof, and the digestive tract mucosa protective agent powder contains gel and a cross-linking agent, the gel comprises any one or a combination of at least two of cellulose, modified cellulose, alginate, modified alginate, sodium polyglutamate, modified sodium polyglutamate, starch, modified starch, sodium hyaluronate, modified sodium hyaluronate, pectin or modified pectin, and the cross-linking agent comprises an ionic cross-linking agent or a nonionic cross-linking agent. The powder protective agent provided by the invention is convenient to produce and simple to use, can be adhered to the surface of a mucous membrane wound surface only through simple spraying operation, forms a hydrogel protective layer under the action of gastric juice, intestinal juice or other liquid on the surface of the wound surface, plays a role of a physical barrier, and has a good application prospect. The continuous erosion of digestible liquid or pathogenic microorganisms on the surface of the wound surface to the wound surface is effectively blocked.

The invention belongs to the technical field of battery dressings, and particularly relates to a wearable magnesium battery self-powered dressing for chronic wound healing and a preparation method and application thereof. A flexible conductive carbon cloth coated with a viologen-based covalent organic framework material is used as a battery positive electrode, a magnesium sheet is used as a negative electrode, polyacrylamide hydrogel is used as a solid electrolyte, and the flexible wearable self-powered dressing is assembled. The formed electrode can effectively input electrical stimulation to the wound surface, the dressing can simulate an endogenous electric field in the wound, induce migration of fibroblasts, regulate the immune microenvironment of the wound and inhibit inflammatory response, polyacrylamide is used as gel electrolyte, and the dressing has good hygroscopicity, can absorb exudate at the wound surface and keep a wet healing environment, and can be applied to the wound healing. The chronic wound healing of the rat is effectively promoted. The self-powered dressing prepared by the invention provides a reliable electrotherapy method for chronic wound healing.

The invention discloses riboflavin photodynamic antibacterial hydrogel for a diabetes wound dressing as well as preparation and application of the riboflavin photodynamic antibacterial hydrogel, and belongs to the technical field of biomedical materials. The hydrogel is prepared from carbomer 941, rhizoma bletillae polysaccharide and carboxymethyl chitosan through physical and chemical bi-crosslinking, glutaraldehyde and carboxymethyl chitosan are added to form dynamic imine bonds, and the stability and adaptability of the hydrogel are enhanced. Meanwhile, the photosensitizer riboflavin is introduced, so that the hydrogel is endowed with photodynamic sterilization characteristics, efficient antibiosis is realized, and rapid healing of diabetic wounds is promoted. The hydrogel has excellent wound environment adaptability and adhesion performance, and is suitable for complicated wound surfaces of diabetes mellitus. The successful research and development of the invention provide reference for the development of novel photodynamic wound dressings, have wide application prospects, provide better treatment choices for diabetics, and are helpful for accelerating wound healing, reducing infection risks and improving the life quality of patients.

The invention belongs to the technical field of biological medicines, and particularly relates to an application of a Pucurbita pepo polypeptide Nacrein-LP20 in preparation of a medicine for promoting wound healing and a preparation method of the Pucurbita pepo polypeptide Nacrein-LP20. The amino acid sequence of the Hepu pearl polypeptide Nacrein-LP20 is as shown in SEQ ID NO: 1 (Sequence Identity Number 1). According to the present invention, the Pucurbita pepo active polypeptide Nacrein-LP20 has characteristics of strong DPPH free radical and hydroxyl free radical removing ability and excellent antioxidant activity, can significantly promote HaCaT cell proliferation in the high glucose environment, and can promote migration and repair of HaCaT cells in the high glucose environment; the traditional Chinese medicine composition has a remarkable healing promoting effect on full-cortical resection wound surfaces of normal rats and diabetic rats.

The invention relates to an antibacterial and hemostatic composite material and a preparation method thereof. The preparation method comprises the following steps: reacting exfoliated graphene oxide with KH560 at 60 DEG C to obtain coupled grafted graphene oxide EGO; then under the condition of intense stirring at 80 DEG C, enabling the kaolin nanotube to react with EGO (Ethylene Gallate Oxide), so as to obtain EGO-EK; and then reacting the chitosan solution with EGO-EK by using a cross-linking agent and a catalyst to obtain a uniform suspension, and freeze-drying. The hemostatic composite material disclosed by the invention has the advantages of bacterial infection resistance, difficulty in tissue adhesion with a wound surface, good mechanical property, photo-thermal effect, excellent biocompatibility and rapid hemostatic capability, and in addition, the hemostatic composite material can accelerate the healing of the bacterial infection wound surface.

The invention discloses a negative pressure electric field dressing, comprising a dressing body, a flexible sealing film for sealing and fixing the dressing body on the wound surface, an iodine ion gel layer is arranged below the dressing body, a negative pressure component connected with the dressing body and generating negative pressure is arranged on the flexible sealing film, and an electric field component connected with the iodine ion gel layer and generating an electric field is also arranged on the flexible sealing film. The dressing has the advantages of convenient replacement and promoting wound healing.

The invention belongs to the technical field of regenerated medical dressings, particularly relates to a plant polysaccharide hydrogel medical dressing for promoting tissue damage repair and application thereof, and provides the following scheme that a medical and mechanical combined product comprises a regenerated medical dressing and a low-temperature sterile storage box for storing the regenerated medical dressing, the regenerated medical dressing comprises a hydrogel main body, open pores formed in the hydrogel main body, sustained-release vesicles arranged in the open pores, and stem cells and a cell culture medium which are filled in the sustained-release vesicles. The stem cell hydrogel can rapidly break blood, rapidly stop bleeding by being attached to a wound surface and promote wound closing, stem cells are inoculated to the upper surface of the hydrogel formed by dendrobium polysaccharides, aloe, lily, coptis chinensis and honeysuckle, safe application of the stem cells is achieved, active factors secreted by the stem cells are slowly released to the skin wound surface, and the wound healing effect is achieved. Through contact stimulation between cells, various cytokines can be secreted better, and the skin repair efficiency is improved.

The invention discloses an osteomyelitis wound microenvironment detection system, and relates to the technical field of osteomyelitis wound microenvironment detection.The osteomyelitis wound microenvironment detection system comprises a leg placing support, a detection support is arranged at the top of the leg placing support and comprises a positioning support and a movable support, and a sensor mechanism is arranged at the end, close to a buckle, of the movable support; the height and the position of the detection support are adjusted, so that the position of a wound surface suitable for a patient can be conveniently selected according to the height and the weight of the patient, and the patient can conveniently take the wound surface of the patient. The sensor array, the electrode system, the signal converter and the data processing module are integrated in the portable equipment, so that relevant indexes such as pH value, humidity and pathogenic microorganisms around a bone infection wound surface can be monitored in real time, various environmental parameters are effectively and comprehensively processed and analyzed, more comprehensive microenvironment information is provided, and the application prospect is wide. And bone infection wounds can be accurately monitored for a long time.

The invention discloses a high-activity injectable self-healing temperature-sensitive hydrogel dressing and a preparation method and application thereof, the high-activity injectable self-healing temperature-sensitive hydrogel dressing is obtained by forming a temperature-sensitive hydrogel through a two-dimensional nano material MXene aqueous solution and F127 under the hydrogen-bond interaction, combining an M2 macrophage source exosome on MXene under the electrostatic adsorption action, and wrapping the MXene through a network structure of the hydrogel. The preparation method is simple, an obtained sample is free of organic solution residues, reaction conditions are mild, operation is convenient, the raw material cost is low, the hydrogel dressing has temperature-sensitive, injectable and self-healing performance, the hydrogel dressing has temperature-sensitive and injectable performance, is sol at normal temperature, forms gel after making contact with skin and is convenient to smear and use on wounds, and experimental results prove that the hydrogel dressing has good application prospects. The hydrogel has good biocompatibility and relatively strong antibacterial performance, and can effectively play anti-inflammatory and vascular regeneration promoting roles in diabetic wounds and promote rapid repair of the diabetic wounds.

The invention relates to the technical field of biomedical dressings, in particular to a dressing for a diabetic foot wound surface and a preparation method of the dressing. 0.2 to 0.8 part of reduced graphene oxide; 2 to 5 parts of beta-1, 3-glucan modified by chondroitin sulfate; 0.08 to 0.3 part of silver nitrate; 3 to 7 parts of N-isopropyl acrylamide-co-acrylic acid; 0.15 to 0.4 part of N, N '-methylene bisacrylamide; 2 to 5 parts of sulfhydrylated hyaluronic acid; 0.3 to 0.8 part of D-alpha-vitamin E polyethylene glycol succinate; 2 to 5 parts of amino-functionalized mesoporous silica; 1 to 3 parts of L-arginine-L-glutamate; 0.1 to 0.4 part of genipin; the super-strong mechanical property and the super-strong flexibility are realized, so that the dressing can better adapt to the irregular shape of a wound surface, and continuous protection is provided.

The invention relates to a wound surface mixed bacteria unmixing method and system based on a double-branch attention mechanism, and belongs to the technical field of biomedical engineering and image processing. The method comprises the following steps: S1, acquiring hyperspectral images of a single strain culture dish, a blank culture dish and a mixed strain wound sample; s2, performing data extraction and preprocessing on the sample hyperspectral image, enhancing the data based on a spectral linear hybrid model and an adversarial generative network, and generating and synthesizing mixed bacteria hyperspectral data; s3, constructing a mixed bacteria unmixing model based on a space-spectrum double-branch attention mechanism; s4, inputting the synthesized mixed bacteria spectrum data into a mixed bacteria unmixing model for training, and optimizing parameters of the model according to the minimum total loss function of the model; and S5, inputting the hyperspectral data of the mixed bacteria wound sample to be unmixed into the trained mixed bacteria unmixing model, and outputting the unmixing abundance of the sample and the corresponding end metainformation.

The invention discloses a preparation method and application of a double-layer sound transmission type berberine-loaded gelatin microsphere slow-release antibacterial gel dressing, and belongs to the technical field of gel dressings. The preparation method comprises the following steps: taking vinyl silicone oil and silicon dioxide as raw materials, preparing upper-layer silica gel by adopting a double-component uniform mixing method, and then laminating the upper-layer silica gel and lower-layer berberine-loaded gelatin microsphere hydrogel by adopting a self-laminating method, thereby obtaining the double-layer sound-transmission type berberine-loaded gelatin microsphere slow-release antibacterial gel dressing. By means of the broad-spectrum antibacterial function of berberine, the efficient drug loading function and slow drug release function of gelatin microspheres, the sound transmission and swelling functions of lower hydrogel and the supporting function of upper hydrogel, ultrasonic inspection is conducted through a dressing covering layer, an ultrasonic scanning supporting plane is provided, ultrasonic waves penetrate through the dressing, good imaging is formed, and the application prospect is wide. And antibacterial and repairing effects on local wounds are realized at the same time.

The invention relates to the field of surgical esophagus medicine applying, in particular to an esophagus medicine applying system applied to the gastroenterology department, comprising: a medicine injection module comprising a nozzle and an image acquisition assembly; the conveying module comprises a medicine conveying pipe, a flow velocity sensor, a gas flow velocity sensor and a conveying pump; the model construction module is used for generating a three-dimensional model of the esophageal wound surface according to the image of the esophageal wound surface; the control module is used for determining an esophageal peristalsis mode according to the esophageal wound surface three-dimensional model, determining a spraying mode according to the peristalsis mode, including determining a medicine spraying pressure according to a gas flow rate in the esophagus, or determining a medicine spraying distance according to an esophageal liquid flow rate of the esophageal wound surface of a patient, and determining a medicine spraying distance according to the medicine spraying distance. And re-determining the medicine injection distance according to the medicine distribution area of the esophageal wound surface. According to the invention, the accuracy and efficiency of surgical esophageal wound treatment are improved.

The invention discloses a COF electrostatic spinning wound dressing with near-infrared response and antioxidant activity and a preparation method of the COF electrostatic spinning wound dressing, and belongs to the field of application materials and technologies. The COFs are synthesized from cobalt hexafluorophthalocyanine (CoPcF16) and ellagic acid (EA). The COFs is prepared into the spinning membrane, and the COFs spinning membrane has very strong oxidation resistance, can effectively remove excessive endogenous ROS, can respond to near infrared to generate exogenous ROS, and can effectively kill bacteria at a wound and improve blood flow and healing of the wound. The COFs spinning membrane prepared by the invention is simple and convenient in preparation method, good in biocompatibility, strong in oxidation resistance and capable of responding to near infrared to produce ROS, and has strong application potential in the field of treatment of a series of infected wounds, especially treatment of diabetic foot ulcers.

The invention relates to the technical field of wound surface treatment, in particular to a traditional Chinese medicine and VSD drainage combined wound surface repairing method and system, and the method comprises the following steps: based on a wound surface image of a patient, analyzing the image, recognizing the edge position of a wound surface, and evaluating the size of the wound surface through the area and shape of the wound surface to obtain a wound surface size evaluation result. According to the method, by evaluating the size of the wound surface, combining the characteristics of the wound surface, evaluating the matching degree of the traditional Chinese medicine repair liquid and considering the cost of the traditional Chinese medicine repair liquid, the traditional Chinese medicine repair liquid with high cost effectiveness is selected and used, the economic efficiency of medical resources is improved, and a proper VSD device is selected according to the size of the wound surface, so that the medical cost is reduced; by comparing treatment records of similar wounds and combining individual differences of patients, the recovery time is analyzed and predicted, and the dismounting time of the VSD device is determined, so that the individualization and timeliness of treatment are improved, and the treatment efficiency and the satisfaction degree of the patients are improved.

The invention relates to the technical field of hydrogel, in particular to mussel mucoprotein loaded extracellular vesicle hydrogel as well as a preparation method and application thereof. The hydrogel is prepared by adopting a mode of combining human umbilical cord mesenchymal stem cell exosome Exo and mussel mucoprotein MAP; the method has the following advantages: 1, the wound repair effect is improved: the biological activity of the exosome Exo and the adhesion performance of the mussel mucin MAP are utilized to jointly promote the wound repair process, so that the repair effect is improved; 2, the adhesion performance is enhanced: the strong adhesion of the mussel adhesive protein MAP is utilized to ensure that the hydrogel can be tightly attached to the wound surface in a wet environment, and the dressing is prevented from falling off and infection risk; and 3, multifunctionality is realized: the composite hydrogel not only has the basic functions of promoting healing, resisting bacteria and the like, but also can transmit genetic information through exosome Exo, so that tissue regeneration and skin barrier repair are further promoted.

The invention discloses a negative pressure drug delivery dynamic adjusting device for a wound surface and a using method thereof, and relates to the technical field of medical instruments and equipment.The negative pressure drug delivery dynamic adjusting device comprises a machine shell, a control module, a connecting module, a negative pressure module and a drug delivery module in the wound surface are installed in the machine shell, a collecting chamber is arranged on one side of the bottom of the machine shell, and a pressure stabilizing linkage control mechanism is further arranged in the machine shell; the pressure stabilization linkage control mechanism is used for dynamic regulation and control of negative pressure and drug administration in the wound surface; the connecting module is used for uniform negative pressure of the wound surface and drug administration in the wound surface; according to the scheme, multi-mode free combination is adopted, single negative pressure / in-wound drug delivery, synchronous linkage, reverse linkage and an alternating mode are supported, the full-period requirement from acute trauma to chronic repair is met, and intelligent parameter matching is conducted, for example, through pressure-flow closed-loop feedback, when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced, and when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced; when wound exudate is reduced, pulse negative pressure is triggered to promote microcirculation.

The invention discloses a preparation method and application of a marine high-molecular polysaccharide hydrogel wound dressing. The hydrogel is formed by cross-linking the marine polysaccharide composition and the cross-linking agent, and the gelation time is short and is about 15 seconds; pores are uniform and moderate; the self-healing property, the adhesion property and the swelling property are high; the antibacterial effect is strong, and the inhibition rates on escherichia coli and staphylococcus aureus are both higher than 90%; skin irritation and skin allergy are avoided, and the biological safety is high; hemostasis can be rapidly carried out within 10s, and the bleeding amount is obviously reduced; the hydrogel dressing can rapidly shrink and scab a wound surface, has the effect of promoting wound healing, and has the effects of stopping bleeding and promoting wound healing which are obviously superior to those of commercially available hydrogel dressings (German Hydrosorb Gel) (Plt; 0.05), and is a safe and effective high-performance wound dressing. In addition, the hydrogel is simple in formula and high in industrialization prospect, is expected to be developed into novel wound dressings and medical instruments, and breaks through the trapping that domestic hydrogel dressings are mostly dependent on import.

The invention belongs to the technical field of biological materials, and particularly relates to nano composite hydrogel as well as a preparation method and application thereof. In the preparation process of the hydrogel, preparation of gelatin hydrazide and preparation of pullulan oxidation are sequentially completed, then preparation of active component loaded PLGA nanoparticles and self-assembly coating with metal-polyphenol are completed, and finally, the metal-polyphenol coated PLGA nanoparticles are mixed with gelatin hydrazide and pullulan oxidation to form gel in situ. The hydrogel has the characteristics of injectability, self-healing, wet adhesion and the like, the metal-polyphenol layer has the effects of resisting inflammation, resisting oxidation and promoting angiogenesis and generates photo-thermal response to near infrared rays, on-demand controllable release of the drug-loaded nanoparticles is achieved, the composite hydrogel can improve the wound surface microenvironment, promote angiogenesis and inhibit inflammation and scar formation, and the drug-loaded nanoparticles can be applied to wound healing. The ointment is suitable for burns, scalds and various complex wounds.

The invention relates to a flexible cold plasma treatment device based on surface dielectric barrier discharge, a special electrode unit strictly divides the device into a discharge area and a non-discharge area which appear alternately, a through hole capable of being used for drainage and drug application is designed in the non-discharge area, the safety is greatly improved, the connection design of the electrode unit is variable, and the application range is wide. And by matching with a power supply, the same treatment device can perform regional targeted treatment according to wound surface distribution and injury degree. Besides, the device discharge layer, the supporting layer, the waterproof breathable layer and the skin contact layer jointly form a laminated layer with a special function, most of wound exudate is absorbed by the skin contact layer, and a small amount of wound exudate is difficult to continuously immerse into discharge holes in the supporting layer to influence discharge due to obstruction of the waterproof breathable layer, so that plasmas can be smoothly generated on the surface of the device discharge layer, and the wound exudate is prevented from being damaged. And then the liquid permeates through the waterproof breathable layer, or directly penetrates through the skin contact layer to enter the wound surface, or is dissolved in the seepage area and then acts on the wound surface.

The invention discloses application of indobufen in preparation of a medicine for preventing and treating diseases induced by excessive ferroptosis, and particularly relates to the technical field of medicines. The invention relates to an application of indobufen in preparation of drugs for preventing and treating diseases induced by excessive ferroptosis by inhibiting ferroptosis. The indobufen is a ferroptosis inhibitor. The invention provides a new application of indobufen alone or in combination with other drugs in promoting wound healing. Cell and animal level experiments prove that the indobufen can inhibit the local ferroptosis level of the wound surface, so that the wound surface healing is obviously accelerated, and the indobufen has a good clinical application prospect.

The plugging drainage device comprises an outer sleeve, a flushing pipe, an inner suction pipe and an umbrella-shaped plugging mechanism, a plurality of first through holes are formed in the front end of the outer sleeve, the inner suction pipe is arranged in the outer sleeve, a plurality of second through holes are formed in the front end of the inner suction pipe, and the umbrella-shaped plugging mechanism is arranged in the inner suction pipe. The umbrella-shaped plugging mechanism is arranged at the front end of the outer sleeve and can be retracted into the outer sleeve. The device is provided with the plugging mechanism, the fistula can be plugged during flushing, intestinal juice loss is effectively avoided, postoperative recovery of a patient is facilitated, the umbrella-shaped structure is adopted for plugging, compared with bag plugging, the umbrella fabric of the umbrella-shaped structure can be tightly attached to the wound surface, obstruction is effectively avoided, and the application safety of the device is further improved.

The invention discloses a bi-crosslinking gelatin-based hydrogel wound dressing as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method disclosed by the invention comprises the following steps: mixing a gelatin solution and an oxidized konjac glucomannan solution, heating and stirring to obtain a hydrogel precursor solution; and mixing the hydrogel precursor solution with a borax solution to obtain the bi-crosslinked gelatin-based hydrogel wound dressing. According to the method, oxidized konjac glucomannan and gelatin are subjected to Schiff base and Schiff base crosslinking, borax is further added to introduce a dynamic boric acid ester bond effect to enhance a three-dimensional network of the hydrogel, and the dynamic reversible Schiff base effect and the boric acid ester bond effect are enhanced, so that the pore diameter and the swelling ratio of the hydrogel are increased, and the gel strength of the hydrogel is enhanced; due to the good self-healing injectable performance, biodegradability and mechanical property of the hydrogel, the hydrogel can be used as a wound dressing for irregular deep skin wounds, and the technical problem that existing hydrogel is insufficient in treatment of irregular wounds is solved.

The invention relates to an intelligent dynamic negative pressure and phototherapy integrated burn wound treatment device, and belongs to the technical field of medical instruments, the device comprises a contact layer, a conduction layer and a honeycomb support layer, the contact layer drains exudate, the conduction layer is integrated with an optical fiber network and a self-adaptive deformation mechanism, and the honeycomb support layer is connected with an intelligent negative pressure chamber and a gradient sterilization system. The pressure of the negative pressure chamber is dynamically adjusted through a corrugated air bag and a rhombic telescopic unit, and the photo-thermal assembly irradiates the wound surface in a time-sharing mode and maintains the constant temperature. And the sterilization system adopts ultraviolet pulse and a multi-stage filter screen to cooperatively purify the percolate. The intelligent regulation and control module optimizes treatment parameters in real time through a multi-mode sensing network, and full-closed-loop cooperation of negative pressure, phototherapy and sterilization is achieved. According to the device, the limitation of traditional treatment is broken through through integrated design, the wound repairing quality and the anti-infection capacity are remarkably improved, meanwhile, the medical care burden is reduced through modular expansion and a non-invasive monitoring function, and an efficient and safe intelligent solution is provided for burn management.