Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material

Abstract

The invention relates to a modified starch material for biocompatible hemostasis, biocompatible anti-adhesion, tissue healing promotion, absorbable surgery sealing and tissue adhesion. The invention applies biocompatible modified starch to animal tissues, wherein the modified starch material has the molecular weight of more than 15,000 daltons, and the particle diameter of between 1 and 1,000 mu m. The modified starch hemostatic material has stypticity, reduces hemorrhage, blood oozing and tissue fluid oozing of wounds, maintains relative moistening or drying of wound surfaces or the wounds, inhibits bacterium growth and inflammation reaction, and contributes to locally diminish inflammation of the wounds and relieve pain of patients. Moreover, the modified starch material can wash local parts after operation is over and remove redundant modified starch which does not participate in hemostasis, and can easily remove haemostatic under the condition of debridement treatment after self-help and first-aid treatment of war wounds; and hemostatic materials with a small amount of modified starch can be absorbed by the body, so that the pain of tearing of gauzes and bandages on people is avoided.

Description

technical field [0001] The present invention relates to a kind of modified starch material as biocompatible hemostasis, biocompatible anti-adhesion, promotion of tissue healing, absorbable surgical sealant, and tissue bonding, especially a kind of directly acting on human, breast-feeding Wounds of animals, including bloody wounds or wounds with exudate, are used for hemostasis, anti-adhesion, promotion of tissue healing, sealing of wounded tissue sections, prevention of bleeding and interstitial fluid leakage, and bonding of tissues damaged by trauma and surgery Organs, modified starch materials that help tissue repair, avoid or reduce surgical sutures, and can be absorbed by humans and animals. Background technique [0002] Surgical operations and trauma will form bloody wounds, during which a large amount of blood will be lost, and it is necessary to use hemostatic means in time. The use of biocompatible absorbable hemostatic materials to stop bleeding on bleeding wounds ...

AI Technical Summary

Problems solved by technology

First of all, from the aspect of application, this hemostatic material is mainly limited to the hemostasis of skin or soft tissue wounds, and the hemostasis of tissues and organs in the deep part of the body cavity, especially the hemostasis under endoscopy (such as minimally invasive endoscopy, colonoscopy and laparoscopy). During operation) there is still lack of effective means; the second, from the preparation method, epichlorohydrin is a colorless oily liquid, toxic and anesthetic, so producing this product is unfavorable to the environment, and the production cost is also higher; the third, from In terms of hemostatic effect, because its water absorption is not strong enough, the water absorption rate is low, and the speed of water absorption is slow, the hemostatic effect is not ideal, especially for active bleeding. The viscosity of the gel is poor, so the clot formed after interacting with blood has poor adhesion to the tissue, and cannot effectively block the damaged tissue and blood vessels, thus affecting the effect of hemostasis; fifth, during active bleeding, The hemostatic powder is difficult to adhere to the bleeding site and is easily washed away by the blood flow. If the auxiliary material is pressed on the hemostatic powder, the auxiliary material is easily adhered by the blood clot, causing re-bleeding when the auxiliary material is uncovered

Therefore, it is not effective for active bleeding hemostasis

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