1475 results about "Anti adhesion" patented technology

The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of inter-macromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and / or polycations. The polymers are associated with each other and are then either dried into membranes or sponges or are used as fluids or microspheres. Bioresorbable, bioadhesive, antiadhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The antiadhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and / or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and / or medical instruments, and / or deliver drugs to the surgical site and release them locally.

The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and / or polycations. The polymers are associated with each other, and are then either dried into membranes or sponges, or are used as fluids or microspheres. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes and gels can be varied as needed by carefully adjusting the pH and / or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by conditioning the membranes prior to surgical use. Multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Membranes and gels can be used concurrently. Antiadhesion compositions may also be used to lubricate tissues and / or medical instruments, and / or deliver drugs to the surgical site and release them locally.

Tissue adhesives formed by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.

Tissue adhesives formed by reacting poly(hydroxylic) compounds derivatized with acetoacetate groups and / or polyamino compounds derivatized with acetoacetamide groups with an amino-functional crosslinking compound are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; and anti-adhesive applications are described.

A hernia mesh support device includes an outer ring, an inner ring and a plurality of ring support members extending between and interconnected to the outer ring and inner ring. On a first axial side of the outer ring and inner ring is situated a layer of mesh material. On a second axial side of the outer ring and inner ring is situated an anti-adhesion barrier. A plurality of barbed pins or hollow needles extend from the first axial side of the outer ring. A removable protective cover covers the plurality of barbed pins or hollow needles.

Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and / or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.

The invention relates to a modified starch material for biocompatible hemostasis, biocompatible anti-adhesion, tissue healing promotion, absorbable surgery sealing and tissue adhesion. The invention applies biocompatible modified starch to animal tissues, wherein the modified starch material has the molecular weight of more than 15,000 daltons, and the particle diameter of between 1 and 1,000 mu m. The modified starch hemostatic material has stypticity, reduces hemorrhage, blood oozing and tissue fluid oozing of wounds, maintains relative moistening or drying of wound surfaces or the wounds, inhibits bacterium growth and inflammation reaction, and contributes to locally diminish inflammation of the wounds and relieve pain of patients. Moreover, the modified starch material can wash local parts after operation is over and remove redundant modified starch which does not participate in hemostasis, and can easily remove haemostatic under the condition of debridement treatment after self-help and first-aid treatment of war wounds; and hemostatic materials with a small amount of modified starch can be absorbed by the body, so that the pain of tearing of gauzes and bandages on people is avoided.

The invention concerns scaffolds comprising a coating on at least one surface that partially penetrates into the void spaces of the scaffold. The invention further concerns scaffolds comprising a partially penetrated anti-adhesion absorbable membrane layer.

A barrier layer and corresponding method of making provide anti-inflammatory and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.

The construct described herein allows opposing tissues to form adhesions with either side of the construct, as part of the natural healing process. The construct however is multi-layered, wherein the space between the layers provides the protection from unwanted adhesions forming between and bonding separate tissues. In one embodiment, this space between layers of the construct may be developed spontaneously, that is the multiple layers are released by design after a finite time and the opposing tissues are free to move independent of each other, free of adhesions.

A hard surface cleaning composition comprising a coacervate complex having a molar charge ratio Z greater than 0.1, wherein said coacervate complex comprises a copolymer and at least one of two components selected from a surfactant or a polymer, whereby the copolymer is cationic if the polymer, surfactant, or combination of polymer and surfactant is anionic, or the copolymer is anionic if the polymer, surfactant, or combination of polymer and surfactant is cationic, and a method of cleaning hard surfaces, are disclosed.

This invention describes a bioerodible fibrin material which is obtained by mixing fibrinogen and thrombin reconstituted or diluted with a particular high tonic strength medium, free of calcium. Such a fibrin-based biomaterial develops a tight structure with thin fibers and small pore size suitable for use as an anti-adhesion barrier. In this invention, thrombin is no longer the variable which governs the tightness and the porosity of the fibrin material obtained, but still controls the clotting time. The mechanical behavior, high-water capacity, and releasable retention properties for therapeutic agents of this fibrin structure causes the fibrin material to be ideally suited for use as a drug delivery device, capable of delivering proteins, hormones, enzymes, antibiotics, antineoplastic agents and even cells for local and systemic treatment of human and non-human patients.

Coated medical devices and methods for coating such devices are disclosed. The invention is directed to the use of an anti-adhesion agent in a coating for a medical device. More particularly, the invention is directed to a medical device comprising an anti-adhesion agent that prevents the self-adhesion of different portions of a coating disposed on the surface of the medical device. Additionally, this invention is directed to methods for coating such a medical device.

Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscopically, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti-adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The devices are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.

A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.

The invention relates to biocompatible modified starch sponge and use of the biocompatible modified starch sponge as a hemostatic material, an anti-adhesion material, a material for promoting tissue healing, a surgical sealant or a wound tissue adhesive. Modified starch is one or a combination of more than one among pre-gelatinized starch, acid modified starch, dextrin, oxidized starch, esterified starch, etherified starch, crosslinked starch, grafted starch and composite modified starch. The sponge is prepared by vacuum freeze drying of the modified starch and other biocompatible hemostatic material, coagulant, plasticizer and so on. The biocompatible modified starch sponge has the advantages that the biocompatible modified starch sponge has flexible form and good biocompatibility, can be directly acted on bloody wound surfaces, avoids the conditions of hypersusceptibility, infection and difficult healing of wounds caused by adoption of hemostatic materials such as animal source / human source collagens, obviously improves the water absorption speed, has larger viscosity, forms a zymoplastic mixture which has good adhesion, calks broken tissues and blood vessels, and is used for hemostasis of active hemorrhage.

An anti-adhesion membrane is placed onto an implant introduced into a surgical site of a patient to prevent post-surgical adhesions between the implant and surrounding tissue. The implant may comprise either biological material, such as a transplanted organ, or non-biological material such as a medical device. The membrane may be applied in a variety of ways. In one example, a membrane according to the present invention is shrink-wrapped around a pace-maker. In another example, a breast implant is spray-coated or dipped with the membrane material.

The invention provides a nano artificial dura mater with a plurality of functional layers, which comprises a structure with at least two layers; the layer facing the brain is a hydrophobic anti-adhesion electrospun layer; and the layer back to the brain is a hydrophilic nano cytoskeletal layer. The invention also provides a method for preparing the nano artificial dura mater, which comprises the following steps: preparing an electrospun solution of a hydrophobic polymer; preparing an electrospun solution of a hydrophilic polymer; preparing the prepared electrospun solution of the hydrophobic polymer into the hydrophobic anti-adhesion electrospun layer through static spinning; and preparing the hydrophilic nano cytoskeletal layer on the anti-adhesion electrospun layer from the prepared electrospun solution of the hydrophilic polymer through static spinning, receiving a membrane structure, and obtaining the nano artificial dura mater. The mechanical features of the nano artificial dura mater can meet the requirements on tensile strength and flexibility of adaptation diseases; and the nano artificial dura mater can be freely cut as required, and has wide application prospect.

The invention discloses postoperation anti-adhesion hydrogel and a preparing method thereof. The hydrogel is prepared from sodium alginate powder, chitosan powder, acrylamide monomers, N,N'-methylene bisacrylamide, calcium sulfate, ammonium persulfate and N,N,N',N'-tetramethylethylenediamine. The preparing method of the high-strength high-tenacity chitosan and sodium alginate compound hydrogel is easy to operate, parameters are controllable, the materials are easy to obtain, and the solvent is nontoxic or low in toxicity and safe to treat and use; the method integrates advantages of the two natural biological materials, and the requirement for postoperation adhesion prevention of patients and the requirement for nursing care and treatment of medical workers can be met well. The hydrogel is soft, can be attached to the skin easily, has good flexibility and can effectively prevent wound surface adhesion and be degraded and absorbed, secondary trauma is avoided, and the hydrogel is expected to become a novel postoperation anti-adhesion material.

The invention belongs to the field of displayers, and discloses a manufacturing method of a flexible display device. The manufacturing method of the flexible display device comprises the following steps that a rigid substrate is coated with an isolation layer and a frame sealing glue layer, the rigid substrate is coated with organic materials to form a flexible substrate, a flexible display device is manufactured on the flexible substrate, ultraviolet exposure is conducted, and residues are removed. According to the manufacturing method of the flexible display device, radical group matter is added to enable the isolation layer to have anti-adhesion performance, the periphery of the isolation layer is coated with the modified frame sealing glue layer, the frame sealing glue layer has good anti-adhesion performance, the ultraviolet exposure is conducted, the frame sealing glue layer is resolved, and therefore the flexible substrate is naturally separated from the rigid substrate. According to the manufacturing method of the flexible display device, separating performance is good, the residues are few, technological process is simple, and the manufactured flexible display device is good in flexibility, and good in display quality.

The invention relates to an anti-adhesion hernia repair patch which comprises a mesh fabric substrate and an electrostatic spinning anti-adhesion layer connected with the mesh fabric substrate. The pore diameter of the electrostatic spinning anti-adhesion layer is 10nm to 2,000nm, while the preferred pore diameter is 50nm to 1,500nm and the more preferred is 100nm to 800nm. After being transplanted into human body, the anti-adhesion hernia repair patch can not only repair hernia, but also prevent post-operation adhesion and can reduce effusion, thus reducing infection.

Bacterial agents for preparing compositions which are for cosmetic, pharmaceutical or veterinary use and which are intended to stabilize and / or regulate the cutaneous ecosystem of mammals. These bacterial agents are extracts of a bacterium, or a bacterium and are selected for their adhesion to skin cells and anti-adhesion to pathogens of the cutaneous system. The invention also relates to compositions containing such agents.

The invention relates to a waterproof and moisture-permeable coating agent composition, wherein, a certain amount of microporous lignocellulose fine powder is added into the coating agent with waterproof function, so that the coating agent has moisture permeable performance. The waterproof and moisture-permeable coating agent composition which is used as the coating agent for non-woven fabric, knitted fabric or woven fabric can be made into coated fabric and synthetic leather with waterproof and moisture permeable performances. Compared with the prior at, the invention has the advantages that: 1. the raw material is easy to be added, the process is available with high adaptability, no need to add new equipment; 2. on the premise that the waterproof performance is not decreased, the amount of moisture permeated is increased obviously and the anti-adhesion is improved; 3. the coated fabric and superfine fiber and artificial cover synthetic leather made by the invention has the advantages of fine moisture permeability, high resistance to water pressure and that the physical performance does not decrease.

An anti-adhesion wound barrier fabricated from amnion obtained from human birth tissue and treated with a glutaraldehyde solution is provided. The amnion is treated in 1% glutaraldehyde solution for up to 15 minutes to fix the amnion. Methods of processing the birth tissue to prepare the amnion for use as a wound barrier are also provided. Use of the amnion anti-adhesion wound barrier for dressing wounds is also described.

The invention relates to a paint mist coagulant. The paint mist coagulant has good anti-adhesion and coagulation effects on water-soluble and fat-soluble paints and is particularly applied to circulating water treatment of a wet paint mist removing system. The paint mist coagulant comprises an anti-adhesion agent A, a flotation agent B and a regulator C which are used simultaneously, wherein the anti-adhesion agent A is formed by combining water-soluble quaternary ammonium cationic polymer, amphoteric metal salt or polymer of the amphoteric metal salt, and a surfactant, has high electrical neutralization property, can quickly neutralize paint particle charges, and coats paint particles to make the viscosity of the paint particles lost; the flotation agent B is anionic polymer with the molecular weight of 8,000,000 to 25,000,000, has a strong coagulation effect, and can aggregate the paint particles of which the viscosity is lost; and the regulator C is used for regulating the pH of circulating water, controls the pH value of the circulating water to be between 7 and 10 commonly, and has small using amount. The paint mist coagulant is low in price, the process is stable, the total sewage discharge amount is small, and continuous production can be ensured.