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Anti-adhesion hernia repair patch

An anti-adhesion and hernia repair technology, applied in medical science, prosthesis, surgery, etc., can solve problems such as effusion, concurrent infection, etc., achieve the effect of simple process, reduce infection complications, and prevent adhesion

Active Publication Date: 2009-09-16
TRANSEASY MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage of the dense anti-adhesion layer is that since body fluids cannot pass through, fluid accumulation may occur, and even concurrent infection

Method used

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  • Anti-adhesion hernia repair patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0016] figure 1 Given an embodiment of the anti-adhesion hernia repair patch according to the present invention, the anti-adhesion hernia repair patch 10 comprises a mesh braided substrate 11 and an electrospun anti-adhesion bonded to said meshed braided substrate 11. Layer 12.

[0017] Unless otherwise clearly stated, the term "mesh braid" used herein has a well-known meaning in the art, and it is described in other patent applications of the present inventor, such as CN200610107652.0, which is hereby incorporated by reference The application is incorporated herein. Specifically, monofilament knitting, multifilament knitting, monofilament weaving, multifilament weaving, and the like are included. The wire diameter can be 0.1-0.2 mm, and the thickness can be 0.4-0.8 mm, more preferably 0.5-0.7 mm. According to the characteristics of the weaving process, the size of the pores of the "mesh braid" is usually hundreds of microns to several millimeters, or even larger. In the pr...

Embodiment 1

[0031] Embodiment 1, the preparation of chitosan electrospinning anti-adhesion film

[0032] Dissolve chitosan with a certain molecular weight of 100kD in 2% (w / w) glacial acetic acid solution at room temperature to prepare a 4% (w / w) chitosan solution and stir for 2 hours to obtain a transparent light yellow color Chitosan in glacial acetic acid solution. The solution was added to the metering pump, and an aluminum foil was placed 10 cm away from the nozzle as a collection device. The high voltage electrostatic adjustment range is 10kV, and the flow rate is 0.2ml / h. Obtain the chitosan anti-blocking film that the spinning fiber of diameter 250-1000nm is formed, pore 50-1500nm (as image 3 shown).

Embodiment 2

[0033] Embodiment 2, anti-adhesion hernia repair sheet prepared by hot-melt method

[0034] Get the chitosan film prepared in the embodiment 1 of 5 * 5cm and spread evenly on 5 * 5cm polypropylene weaving net (gram weight: 45g / m 2 )superior. The two-layer structure was placed between Teflon-coated molds at 100° C., 0.1 MPa. After 30 seconds, it was taken out and cooled to obtain an anti-adhesion hernia repair sheet with a two-layer composite structure. Its weight is 61g / m 2 , the vertical bursting strength is 170N, and the lateral bursting strength is 146N.

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Abstract

The invention relates to an anti-adhesion hernia repair patch which comprises a mesh fabric substrate and an electrostatic spinning anti-adhesion layer connected with the mesh fabric substrate. The pore diameter of the electrostatic spinning anti-adhesion layer is 10nm to 2,000nm, while the preferred pore diameter is 50nm to 1,500nm and the more preferred is 100nm to 800nm. After being transplanted into human body, the anti-adhesion hernia repair patch can not only repair hernia, but also prevent post-operation adhesion and can reduce effusion, thus reducing infection.

Description

technical field [0001] The present invention relates to instruments for clinically repairing hernias, and more particularly, the present invention relates to adhesion-resistant hernia repair patches. Background technique [0002] Hernia refers to the rupture or weakening of the abdominal wall supporting the organs at a certain part, so that the internal organs of the abdomen protrude to the body surface through the rupture or weakening part, forming a local mass. At present, the most commonly used method of repairing hernia clinically is to first open an opening at the site where the hernia occurs, push the organs squeezed into the site back into the abdominal cavity, and then insert a mesh braid made of biocompatible materials into the abdominal cavity. A prosthetic instrument is placed in the opening and held in place by suturing or otherwise, and the opening is then closed. The advantage of this approach is that, if performed properly, the tissue near the opening undergo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61F2/00A61L31/04A61L31/14A61L27/14A61L27/58A61B17/00
Inventor 孟凯郭伟孙杰荆江
Owner TRANSEASY MEDICAL TECH
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