The invention relates to the technical field of
medical instruments, and provides an anti-infection and anti-adhesion
hernia repair biological patch and a preparation method thereof.
Bacterial cellulose is used as a base material,
quaternary ammonium salt
grafting modification is carried out on the
bacterial cellulose through an oxidation catalytic reaction, so that the
bacterial cellulose has long-acting and stable antibacterial ability, then natural
protein bioactive materials are compounded, the
biological activity of the patch is improved, and
protein antibacterial substances are compounded, so that the antibacterial patch is prepared. The antibacterial capability and the
biological activity function of the patch are further improved, and the slowly released
protein antibacterial substances and the
quaternary ammonium salt grafted on the surface of the
bacterial cellulose have a synergistic effect, so that efficient and broad-spectrum
bacterial killing can be realized, and infection caused by invasion of
bacteria can be effectively resisted. In conclusion, the biological patch provided by the invention is good in repairing effect, capable of preventing complications such as visceral adhesion and the like, excellent in
antibacterial property and wide in application prospect.