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30 results about "Hernia repair" patented technology

Hernia repair refers to a surgical operation for the correction of a hernia—a bulging of internal organs or tissues through the wall that contains it. It can be of two different types: herniorrhaphy; or hernioplasty. This operation may be performed to correct hernias of the abdomen, groin, diaphragm, brain, or at the site of a previous operation. Hernia repair is often performed as an ambulatory procedure.

Hernia repair mesh with opening with leaflets

PCT designated stageWO2026044098A1ProsthesisSurgeryBiomedical engineering
A hernia repair mesh for providing structural support to a repaired anatomical member. The hernia repair mesh (100) includes a mesh frame (110) and a central opening (120) disposed within the mesh frame, configured to surround a first anatomical member and allow it to pass through the mesh frame. The repair mesh comprises a plurality of flexible leaflets (135) extending inwardly from a perimeter of the central opening. Each of the flexible leaflets is configured to allow movement of the first anatomical member in a first direction while providing resistance against movement of the first anatomical member in a second direction.
Owner:SYN LLC

Hernia stapler

1. The name of the design product: hernia anastomat. 2. The use of the design product: the design product is used for tissue suture in hernia repair. 3. The design points of the design product: the shape of the design product. 4. The picture or photo that best shows the design points: perspective view.
Owner:SUZHOU YINGTUKANG MEDICAL TECH CO LTD

Hernia repair, breast reconstruction and sling devices containing poly(butylene succinate) and copolymers thereof

Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially / fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.
Owner:TEPHA INC

Composite hernia repair patch with ease of fixation

ActiveCN224474488UAdhesive glueAnti bacterial
The utility model discloses a kind of composite hernia repair patch of being convenient for fixed, it is related to hernia repair patch technical field, including patch body, the patch body includes support layer, the surface of support layer is passed through being set up multiple mouth, and fixedly connected with multiple light weight big mesh mesh, the support layer includes framework layer, the side surface of framework layer is fixedly connected with biological layer, the top of biological layer is fixedly connected with anti-adhesion layer, the other side surface of framework layer is fixedly connected with promoting coating;The patch body provided in the utility model is under the basis of being convenient for fixing hernia repair patch to carry out antibacterial protection, to solve the problem that the pre-fixing effect of patch is poor and thus affects subsequent sewing needle or hernia nail work when the most part of glue can flow out of patch range when pre-fixing of existing composite hernia repair patch.
Owner:BIOHEALTH MEDICAL TECH CO LTD

Medical repair membrane with orthogonal limited split structure and preparation method thereof

PendingCN122351597AFiberCrazing
This invention provides a medical repair membrane with an orthogonal crack-limiting structure and its preparation method. This invention relates to the field of biomedical materials technology. The medical repair membrane of this invention comprises at least two electrospun fiber layers, which intersect to form an orthogonal fiber structure. Layer B, facing tissue integration, adopts a coaxial core-shell structure. The shell layer contains biodegradable polymers and bioactive components, while the core layer is a biodegradable polymer. The structure of this invention effectively inhibits crack propagation and improves the structural stability of the material. Simultaneously, the core-shell structure enables controlled release of active components and tissue-selective induction, balancing mechanical properties and biocompatibility. The medical repair membrane is suitable for soft tissue defect repair, such as dura mater repair, fascia repair, pericardial repair, and hernia repair.
Owner:HEAYOUNG MEDICAL TECHNOLOGY (SUZHOU) CO LTD

Hernia repair patch and method of making same

The application provides a hernia repair patch and a preparation method thereof, and relates to the technical field of medical materials.The hernia repair patch comprises a multilayer structure or a single layer structure, and the outer layer of the multilayer structure has a pore size structure of 50-300 mu m.The hernia repair patch is provided with the multilayer structure, the pore size structure on the outer layer is convenient for tissue cell adhesion and nutrient substance flow, and thus can effectively promote rapid tissue growth.In addition, the hernia repair patch can be prepared from various degradable biomaterials, has good mechanical properties, and has the technical effect that the hernia repair patch is absorbable in the body.
Owner:SUZHOU RUIJINUO MEDICAL TECH CO LTD

A pre-installed adjustable hernia repair patch and its preparation method

PendingCN122075180Aadjustable positionStrong fault toleranceProsthesisFibroblastSurgery
This invention discloses a pre-placed adjustable hernia repair patch and its preparation method, relating to the field of medical device technology. The patch body is a polypropylene woven mesh with a weight of less than 50 g / m². The polypropylene woven mesh has a double-layer gradient structure with different densities on both sides. This pre-placed adjustable hernia repair patch uses a double-layer gradient structure of the same woven mesh. The outer layer has large pores (80-300 μm) to facilitate fibroblast ingrowth and tissue fixation, while the inner layer has small pores (15-80 μm) to form a physical barrier, effectively inhibiting visceral adhesions. It addresses both fixation and anti-adhesion needs. Temporary fixation is achieved through sliding PLGA fixation pins, pre-drilled holes, and elastic rings. The fixation pins are available in various lengths, and the elastic rings enable temporary fixation and position adjustment. Blue marking lines facilitate directional identification, and barium sulfate contrast markers aid in intraoperative positioning and postoperative follow-up.
Owner:BEIJING ZIYANGE CONSULTING CO LTD

A decellularized dermis-containing biological patch for hernia repair and a preparation method thereof

PendingCN122624754AHuman bodyGenipin
The application discloses a kind of for hernia repair containing acellular dermis biological patch and preparation method thereof, belong to biomedical material field, raw material includes acellular porcine dermis layer matrix 90-110 parts, genipin 0.1-0.2 parts, EDC 0.8-2.5 parts, NHS 0.3-1 part, carboxymethyl chitosan 3-8 parts, sodium hyaluronate 1.5-4 parts, chondroitin sulfate 0.5-2 parts, glycerol 2-5 parts, modified zinc tannate nanocomposite 3-12 parts, effectively solve the problems that existing hernia repair patch anti-adhesion and tissue ingrowth is difficult to coordinate, support strength and degradation rate are not matched, foreign body exists in human tissue for a long time and leads to inflammation, by introducing anti-adhesion coating containing zinc tannate coordination nanocomposite and asymmetric double-sided structure, the patch realizes abdominal cavity side long-acting anti-adhesion, abdominal wall side rapid tissue integration and controllable degradation and mechanical support under low immunogenicity.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Method for preparing biodegradable magnesium metal hernia repair patch and patch implantation system

This invention discloses a method for preparing a biodegradable magnesium metal hernia repair patch and a patch implantation system, belonging to the field of patch technology. The method for preparing the biodegradable magnesium metal hernia repair patch includes: using a magnesium plate as the base material, with a mesh size of 0-70%, and the outer contour of the patch having wavy edges or rounded corners; the thickness of the biodegradable magnesium metal hernia repair patch being 0.05mm to 0.5mm; selecting a magnesium alloy ingot as the base material, and extruding and rolling the base material into an ingot plate of a predetermined size; annealing the ingot plate in an annealing furnace at 180°C for 1-2 hours, removing it, and leveling it to form a magnesium plate; processing the mesh and outer contour on the magnesium plate using cutting or stamping equipment to form a prototype patch; polishing, cleaning, packaging, and sterilizing the prototype patch to obtain the biodegradable magnesium metal hernia repair patch, which is not only absorbable by the human body but also has low plasticity and hardness, making it easy to store and implant in the body.
Owner:SUZHOU ORIGIN MEDICAL TECH

Hernia repair patch resistant to mechanical distortion

The utility model discloses a hernia repair patch tolerant to mechanical distortion, which comprises a patch body, the patch body is of a net structure formed by weaving monofilament structures, each monofilament structure comprises an anti-torsion wire, a polypropylene fiber layer and an antibacterial layer, the polypropylene fiber layer is sleeved on the outer side of the anti-torsion wire, and the antibacterial layer is sleeved on the outer side of the polypropylene fiber layer. And an antibacterial layer is arranged on the outer wall of the polypropylene fiber layer. According to the hernia repair patch resistant to mechanical distortion, through cooperation of the patch body, the monofilament structure, the anti-torsion wires, the polypropylene fiber layer and the antibacterial layer, when the net-shaped patch main body structure woven by the monofilament structure is used, the anti-torsion wires in the center of the interior of the monofilament structure have certain memory and elastic performance, and the mechanical distortion resistance of the mesh-shaped patch main body structure is improved; the mechanical distortion resistance of the patch body can be improved to a certain extent, foreign body sensation in the body of a patient after the patch is used can be effectively reduced, and the follow-up recurrence rate and the probability of complications of the patient can be reduced by matching with the antibacterial effect of the antibacterial layer on the outer side of the polypropylene fiber layer.
Owner:SUQIAN SHENGXING MACHINERY CO LTD

Hydrogel coated surgical meshes and uses thereof

PCT designated stageWO2026148415A1Surgical operationSurgical site infection
Described herein are hydrogel-coated surgical meshes and their use in hernia repair, reconstructive surgery, and other surgical procedures. In one aspect, the hydrogel-coated meshes comprise at least one antibiotic or antimicrobial agent for the treatment of hernia repair surgery. In one aspect, the hydrogel coated meshes provide localized, sustained antimicrobial activity for the treatment of surgical site infections. In one aspect, the hydrogel coated meshes provide localized, sustained prophylactic antimicrobial activity for the prevention of surgical site infections. In another aspect, the hydrogel coating may optionally include one or more additional therapeutic components, such as anti-inflammatory compounds or growth factors, to facilitate and enhance recovery following hernia repair, reconstructive procedures, or other surgeries.
Owner:AMACATHERA INC

Preparation method of anti-adhesion, pro-repair and antibacterial composite patch

ActiveCN117883639BPoly-L-lactideSurgical operation
The application discloses a preparation method of an anti-adhesion, repair-promoting and antibacterial composite patch. L-lactide and glycolide are used as monomers to synthesize four-arm polylactic acid-glycolic acid 4arm-PLGA through ring-opening polymerization; then, L-lysine and 1,2-propylene glycol are used to prepare hydrophilic BLPD through esterification reaction, and the 4arm-PLGA is copolymerized with the 4arm-PLGA to obtain a block copolymer 4arm-PLGA-BLPD; subsequently, the proportion of PCL, the 4arm-PLGA-BLPD, the 4arm-PLGA and an antibacterial drug is regulated, and the composite patch is prepared through continuous electrospinning technology. The composite patch has good biosafety, antibacterial property, anti-adhesion between the patch and human organs and repair-promoting property, and has a wide application prospect in surgical operations, especially in hernia repair.
Owner:SOUTHEAST UNIV +1

Method for manufacturing absorbable metal hernia repair patch and laparoscopic operating system

ActiveCN116748806BMg alloysIngot
The application discloses a preparation method of absorbable metal hernia repair patch and a laparoscopic operation system, and belongs to the technical field of medical devices. The preparation method of the absorbable metal hernia repair patch comprises the following steps: selecting magnesium and magnesium alloy ingots as base materials; the base materials are extruded and rolled into plate materials; the plate materials are annealed in an annealing furnace at a temperature of 150 DEG C to 200 DEG C for 1 h to 2 h, taken out and flattened to form magnesium plates, and the thickness of the magnesium plates is 0.05 mm to 0.5 mm; cutting equipment or stamping equipment is used to process the mesh holes and the outer contour on the magnesium plates to form a rough hernia repair patch, the mesh hole ratio of the patch in the rough hernia repair patch is 0-70%, and the outer contour is provided with a wavy edge or a round corner; and the rough hernia repair patch is polished, cleaned, packaged and sterilized to obtain the absorbable metal hernia repair patch. The application can not only be absorbed by the human body, but also has good flexibility, can be bent along with the human abdominal wall tissue, is convenient to store and implant in the body.
Owner:SUZHOU ORIGIN MEDICAL TECH

Application of composite biological material in hernia repair operation

The invention discloses application of a composite biological material in hernia repair surgery, and belongs to the technical field of biotechnology, the composite biological material comprises a nanofiber scaffold, the scaffold is prepared by compounding polylactic acid-glycolic acid and silk fibroin, the weight ratio of the polylactic acid-glycolic acid to the silk fibroin is 70: 30, and the weight ratio of the polylactic acid-glycolic acid to the silk fibroin is 20: 30. The nanofiber scaffold is prepared through an electrostatic spinning technology and is used for providing mechanical support and promoting cell attachment and proliferation; the fiber is of a porous structure, the pore size is 10-100 microns, and cell permeation and nutrient substance exchange are facilitated; the polylactic acid-glycolic acid / silk fibroin composite scaffold is prepared by compounding polylactic acid-glycolic acid and silk fibroin, the mechanical properties of natural tissues are simulated, and a good growth scaffold is provided for cells. The gel layer is prepared through a solution phase separation method, and provides additional biological activity support and a cell attachment surface for the nanofiber scaffold. By arranging the antibacterial coating, the risk of postoperative infection is reduced, and meanwhile, protection is provided for materials and human tissues.
Owner:GUANGDONG GENERAL HOSPITAL

A large-mesh hernia repair patch

The utility model relates to medical supplies technical field discloses a big mesh hole hernia repair patch, including a plurality of medical textile monofilament, a plurality of antibacterial fiber and a plurality of flow fiber, a plurality of medical textile monofilament and a plurality of flow fiber are respectively perpendicular to each other interlaced weaving arrangement, a plurality of antibacterial fiber is respectively arranged in the clearance of a plurality of parallelly arranged flow fiber, the side wall of a plurality of flow fiber is respectively surrounded and is opened a plurality of drainage holes. The utility model provides a plurality of medical textile monofilament, a plurality of antibacterial fiber and a plurality of flow fiber are arranged mutually, and the interval is set to 3mm, can improve the mesh size of patch, does not influence the fibrous tissue production of affected part simultaneously can reduce the rejection phenomenon, and antibacterial fiber has excellent biocompatibility, can be absorbed and metabolized by human body part, contains amino in its molecular structure, makes it have antibacterial activity, can improve the antibacterial effect of patch, prevents the situation of infection.
Owner:BIOHEALTH MEDICAL TECH CO LTD

Bioresorbable knit for hernia repair and method for manufacturing the same

The present invention relates to a bioresorbable prosthetic porous knit comprising an arrangement of yarns of bioresorbable biocompatible material defining at least two sides for said knit, said knit being provided, on one of its sides, with barbs protruding outwards from said one side, wherein each yarn of the arrangement defining said two sides is doubled. The invention further relates to a method for manufacturing such a knit.
Owner:SOFRADIM PRODUCTION SAS

A repair fixer for laparoscopic hernia repair

ActiveCN224474445ULaparoscopic hernioplastyHand parts
The utility model discloses a kind of repair fixers for laparoscopic hernia repair, it is related to medical instrument technical field, the utility model includes fixed base, the inner wall of fixed base is fixedly connected with storage glue pipe, the outer wall of fixed base is fixedly connected with motor frame, the utility model is connected with several finger cots by being set, several finger cots are all adhered to the four fingers of user except thumb during use to prevent equipment from easily falling off from the hand of user, when several finger cots are displaced due to finger movement, it will drive displacement plate two displacement, displacement plate two will drive several shaft seat displacement, one end of several shaft seats is rotated and displaced, several shafts are all driven shaft seat displacement, enough friction is provided to the four fingers of user except thumb when it is held by user to carry out repair work, prevent user from falling off from the hand of user due to frequent movement equipment in use process, equipment is caused to fall off from the hand of user accidentally.
Owner:BIOHEALTH MEDICAL TECH CO LTD

Endoscope equipment capable of controllably releasing hernia repair patch

InactiveCN121587655ASurgeryLaproscopesMedicinePERITONEOSCOPE
The invention belongs to the technical field of laparoscopes, and particularly relates to endoscope equipment capable of controllably releasing a hernia repair patch, and the endoscope equipment comprises a handheld part which is used for being held by a doctor; one end of the long-strip-shaped optical sight glass is fixedly arranged in the handheld part in a penetrating mode; the conveying mechanism is movably arranged on the optical sight glass in a sleeving manner; the conveying mechanism comprises a driving frame, wherein one end of the driving frame is movably arranged on the optical sight glass in a sleeving mode; and the sealing plate is fixedly arranged on the inner wall of the other end of the driving frame. The planetary rods surround the periphery of the optical sight glass, the rubber strips spirally surround the peripheries of the planetary rods, and when the rubber strips synchronously rotate, the surfaces of the rubber strips rub the optical sight glass to drive the optical sight glass to move; the rotating angles of the rubber strips are in direct proportion to the moving distance of the optical sight glass, and by accurately adjusting the rotating angles of the rubber strips, the advantage that the optical sight glass moves accurately is achieved.
Owner:HANDAN 285 HOSPITAL

Prosthesis for hernia repair

The present invention relates to a prosthesis (1) for hernia repair comprising a reinforcement layer (2), a first barrier layer (3) of anti-adhesion material covering at least a part of a surface of the reinforcement layer, and a second barrier layer of anti-adhesion material covering a remaining part of the surface of the reinforcement layer, the second barrier layer being formed of one or more flap member(s) (4).
Owner:SOFRADIM PRODUCTION SAS

Three-dimensional patch for esophageal hiatus hernia repair

The invention discloses a three-dimensional patch for esophageal hiatus hernia repair, and relates to the technical field of human life necessities. A three-dimensional patch for esophageal hiatus hernia repair comprises a patch body and an esophagus lower end connecting piece, the esophagus lower end connecting piece is in a U shape and is connected and sewn with the lower end of an esophagus, the two ends of the patch body are in an arc shape and a plane shape respectively, the patch body is made of a silk collagen material, and the silk collagen material has the slow absorbable characteristic; the patch body is gradually degraded into carbon dioxide and water within about two years, the process is matched with the natural repairing process of esophageal pore tissue, meanwhile, the two ends of the patch body are in an arc shape and a plane shape respectively, the patch body is matched with the U-shaped esophageal lower end connecting piece, the complex anatomical structure of the esophageal pore and surrounding tissue can be precisely matched, and the repairing effect is good. The arc-shaped end conforms to the bending form of the connecting part of the esophagus and the stomach, and the U-shaped esophagus lower end connecting piece is attached to the diaphragm radian around the esophageal crack hole, so that the patch is tightly attached to the tissue, and the repairing effect is improved.
Owner:陈双

Soft tissue repair prosthesis and expandable device

A hernia repair device is provided which may include a soft tissue repair prosthesis and an expandable device configured to be removably connected with the soft tissue repair prosthesis. Attachment components may be used to removably connect the soft tissue repair prosthesis with the expandable device. The hernia repair device may be manipulated into a reduced configuration for insertion into the body. When expanded, the expandable device may be configured to position the soft tissue repair prosthesis adjacent a hernia defect. The expandable device and / or the attachment components may be shaped and / or configured to minimize the maximum dimension of the hernia repair device in its reduced configuration.
Owner:CR BARD INC

Repair fixation device with safety lock

This invention relates to the field of hernia repair fixation technology, and more particularly to a repair fixation device with a safety lock. It includes: a fixation body; a first pin mounted on the fixation body, a handle mounted on the fixation body via the first pin, and a locking pin that can slide back and forth inside the fixation body; the front and rear ends of the handle are respectively provided with a limiting groove and an arc-shaped sliding groove, the handle is provided with a waist-shaped through groove, a second pin is installed in the waist-shaped through groove, and a rebound rod is installed inside the fixation body; the left end of the rebound rod abuts against the right side of the second pin; the rear end of the locking pin moves within the arc-shaped sliding groove, and the front end of the locking pin is fitted into the limiting groove. This invention can reliably lock the handle, preventing premature release of the repair fixation pin due to accidental contact with the handle, thus improving the effectiveness of the repair fixation device.
Owner:RIZHAO TIANYI BIOMEDICAL PTE LTD

Bacterial cellulose / collagen composite active hernia patch material and in-situ biosynthesis method thereof

The invention discloses a bacterial cellulose / collagen composite active hernia patch material and an in-situ biosynthesis method thereof. The method comprises the following steps: extracting collagen from a collagen extraction raw material to obtain purified collagen sponge, dissolving the collagen sponge in water to obtain a collagen solution, adding an oil phase into the collagen solution, and emulsifying to obtain a collagen-based Pickering emulsion; and then, by taking the collagen Pickering emulsion as a template, forming the bacterial cellulose / collagen composite active hernia patch material in an acetobacter xylinum in-situ fermentation culture manner. The bacterial cellulose / collagen composite active hernia patch material with a macroporous structure on one side and an original compact structure on the other side is provided, the macroporous structure of collagen provides a channel for migration of cells and transportation of metabolites, and the compact structure of bacterial cellulose keeps the original high mechanical strength of bacterial cellulose; therefore, the material is favorable for promoting hernia repair.
Owner:FUJIAN UNIV OF TECH

Prosthetic repair fabric

PendingJP2026004362AWarp knittingMedical devicesProsthetic limbChest wall reconstruction
To provide a prosthetic repair fabric for repairing soft tissue and muscle wall defects.SOLUTION: The repair fabric includes a double bar warp knit mesh for use in the repair of soft tissue and muscle wall defects, including hernia repair and chest wall reconstruction. The repair fabric may be manufactured according to a first bar pattern chain of 4 / 24 / 64 / 26 / 86 / 46 / 8 of the first filament and a second bar pattern chain of 6 / 82 / 06 / 84 / 28 / 104 / 2 of the second filament. The diameter of the first filament is different from the diameter of the second filament.SELECTED DRAWING: Figure 1
Owner:DAVOL INC

Method and apparatus for tracking anatomical structures in visually assisted surgery

The present invention relates to an intraoperative anatomical structure tracking and alert system for improving surgeons' situational awareness during laparoscopic and visual-assisted surgery. During laparoscopic and visual-assisted surgery, surgeons can mark anatomical structures (e.g., blood vessels, nerves, bile ducts, and pain triangles in hernia repair) for systemic tracking and continue surgery. As the endoscope moves, the marked structures may become invisible. The system uses synchronous localization and mapping (SLAM) to track and restore the endoscope's exact position. When the camera moves to an angle where the previously marked structure is once again visible, the system redraws the marking to indicate successful tracking of the structure. Additionally, if a surgical instrument (e.g., an energy device) approaches an anatomical structure, an alert (e.g., an audio or visual alert on a screen) can be sent to the surgeon to prompt his or her attention.
Owner:GENESIS MEDTECH INTERNATIONAL PTE LTD

Mesoporous polydopamine coating polypropylene patch loaded with medicine and application of mesoporous polydopamine coating polypropylene patch in herniorrhaphy

The invention discloses a drug-loaded mesoporous polydopamine coating polypropylene patch, and belongs to the field of medical material preparation, a preparation method comprises the following steps: dissolving 450-600mg of a mesoporous template agent in a specific amount of a water / ethanol mixed solvent, then adding 0.6-1.2 mL of a pore-enlarging agent, and treating to obtain a template solution; adding 700-800mg of a DA monomer into the template solution, adding a PP patch, after the DA monomer is uniformly dispersed, adding 1.5-2.0 mL of an alkaline reagent, keeping out of light at room temperature until the DA monomer is subjected to oxidative auto-polymerization, and generating an MPDA coating on the surface of the PP patch to obtain an MPDA-PP patch; immersing the MPDA-PP patch into anti-fibrosis PBS (Phosphate Buffer Solution), and shaking in a dark place until medicine loading is completed, so as to obtain the medicine-loaded mesoporous polydopamine coating polypropylene patch. The patch can realize visual detection while actively inhibiting peritoneal fibrosis, so that the recurrence risk is reduced, the postoperative management accuracy is improved, and an innovative solution is provided for incisional hernia treatment. The invention also discloses an application of the patch in herniorrhaphy.
Owner:SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL

Microneedle / GelMA hydrogel composite hernia patch and preparation method thereof

ActiveCN121360289ACoatingsProsthesisTissue integrationPharmacy medicine
The invention discloses a microneedle / GelMA hydrogel composite hernia patch and a preparation method thereof, the patch comprises a microneedle array layer and GelMA hydrogel, and the GelMA hydrogel covers and adheres to the root of a microneedle head. The microneedle array layer is used for realizing tissue fixation and local drug delivery, and the GelMA hydrogel is subjected to enzymatic crosslinking by an HRP / H2O2 system to form a stable structure and has good flexibility and wet adhesion performance. By combining the biodegradability and tissue integration characteristics of the IV type collagen and the adjustable mechanical and biological adhesion characteristics of the GelMA hydrogel, a minimally invasive, stable and degradable hernia repair scheme is realized, and the hydrogel can be firmly attached to the tissue surface without suture, can be gradually degraded and absorbed after operation, reduces foreign body reaction and organ adhesion, and has a good application prospect. The infection and recurrence risks are obviously reduced, and excellent biocompatibility and clinical application prospects are achieved.
Owner:WUHAN TEXTILE UNIV

Totally absorbable pdo-p4hb binary composite gradient degradation hernia repair patch

This invention discloses a fully absorbable PDO-P4HB binary composite gradient degradable hernia repair patch, comprising: a PDO support layer, a P4HB toughening layer, and multiple composite connection nodes and edge reinforcement rings composed of PDO-P4HB blend materials. This invention uses a fully absorbable and non-immunogenic PDO+P4HB composite material, which can be completely degraded into non-toxic products and excreted from the body through hydrolysis and enzymatic degradation postoperatively, reducing the risk of complications such as infection and adhesions. It is suitable for complex repair scenarios such as infected abdominal wall defects. Utilizing the inherent difference in degradation rates between the two materials, and through specific weaving structures and parameter design, a gradient degradation structure is constructed to achieve a dynamic adaptation process of "early high-strength support (PDO-dominated) – mid-term flexible transition (synergistic between the two) – late complete degradation (P4HB finishing)," meeting both the rigidity requirements of intraoperative operations and the mechanical and biological needs of each stage of tissue repair, balancing support stability and tissue ingrowth.
Owner:BEIJING COMPONT MEDICAL DEVICES CO LTD

A microneedle / gelma hydrogel composite hernia patch and a preparation method thereof

ActiveCN121360289BCoatingsProsthesisTissue integrationPharmacy medicine
The application discloses a microneedle / GelMA hydrogel composite hernia patch and a preparation method thereof, the patch comprising a microneedle array layer and a GelMA hydrogel, the GelMA hydrogel covering and adhering to the root of the microneedle needle. The microneedle array layer is used for realizing tissue fixation and local drug delivery, the GelMA hydrogel is enzymatically crosslinked by an HRP / H2O2 system to form a stable structure, and has good flexibility and wet adhesion performance. The application combines the biodegradability and tissue integration characteristics of type IV collagen and the adjustable mechanics and biological adhesion characteristics of the GelMA hydrogel, realizes a minimally invasive, stable and degradable hernia repair scheme, can be firmly attached to the tissue surface without suturing, can be gradually degraded and absorbed after the operation, reduces foreign body reaction and organ adhesion, significantly reduces the risk of infection and recurrence, and has excellent biocompatibility and clinical application prospect.
Owner:WUHAN TEXTILE UNIV