Hernia repair patch fixing device for animal test and use method of hernia repair patch fixing device

Abstract

The invention discloses a hernia repair patch fixing device for an animal test and a use method of the hernia repair patch fixing device, and relates to the technical field of medical instrument animal tests. The device comprises an annular positioner, an adsorption fixing unit, a slidable suture needle seat and a tension monitoring unit, the annular positioner is provided with a positioning notch and a central positioning plate, so that the patch coverage distance standardization is realized; the adsorption fixing unit ensures stable fixation of the device through a vacuum chuck and a pressure sensor; a tension sensor is arranged in the suture needle seat and is matched with a display screen to quantify tension in real time; during use, operation is completed through the steps of device assembling, positioning adsorption, patch sewing, data recording and disassembling. Through a mechanical positioning and tension feedback system, the problem of patch fixation standardization in animal tests is solved, the method is suitable for animal effectiveness evaluation of various soft tissue regenerative patches, subjective operation differences are eliminated, and the reliability and comparability of test data can be remarkably improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of animal testing of medical devices, in particular to a hernia repair patch fixing device for animal testing and a method for using the same, aiming to improve the positioning accuracy and tension control stability of patch implantation. BACKGROUND

[0002] Soft tissue regenerative hernia repair patches gradually degrade after being implanted in the human body and induce host tissue remodeling and regeneration, ultimately forming a natural tissue repair of abdominal wall defects. This is an important development direction in the current hernia repair field. The regenerative efficacy of such patches needs to be verified through animal testing. Considering the comparability of the abdominal wall anatomic structure and hernia defect repair mechanism between experimental animals and humans, the industry generally chooses adult large animals (such as pigs) to construct abdominal wall hernia defect models for testing.

[0003] In animal testing, the fixing effect of the patch on the abdominal wall defect directly determines the reliability of the test results - the distance of the patch covering the edge of the defect and the uniformity of the fixing tension will all affect the integration efficiency of the patch and the host tissue, the biomechanical properties and the regenerative repair effect. Therefore, the "Animal Testing Technical Review Points for Soft Tissue Regenerative Hernia Repair Patches" clearly requires that the distance of the patch covering the edge of the defect should be at least more than 3 cm, and the fixing process should maintain a "low tension state" to avoid tissue damage or patch displacement.

[0004] However, the patch fixing in the prior art relies on manual suture operation, which has the following defects: 1. Insufficient positioning accuracy: manual suture completely relies on the surgeon's experience to judge the position of the patch, and the distance of the patch covering the edge of the defect can differ by 1-2 cm, which is far from meeting the review requirement of "covering distance ≥ 3 cm and deviation controllable". Such positioning deviation will cause the patch and tissue contact area and stress state of different test samples to be inconsistent, thereby causing systematic errors in the evaluation of patch biomechanical properties (such as tensile strength) and regenerative repair effect; 2. Lack of quantitative means for tension control: in traditional operations, "low tension state" relies on the subjective perception of the surgeon and has no objective quantitative standard. High local tension during suturing can easily cause abdominal wall tissue ischemia, necrosis, and even serum swelling between the patch and the tissue; low tension can cause the patch to shift and wrinkle, making it difficult to closely fit the defect area and affecting tissue regeneration progress; 3. Poor operation consistency: different surgeons have different standards for "low tension" and suturing techniques, and even the same surgeon cannot completely unify the operation in different test batches, resulting in large fluctuations in data between animal test groups and serious lack of comparability and repeatability of test results.

[0005] Therefore, developing a standard fixing device capable of realizing accurate positioning of the patch, quantitative control of tension, and standardization of operation is a technical problem to be solved in the industry, and the present application is an innovative solution to the blank. SUMMARY

[0006] In view of the above problems, the present application aims to provide a hernia repair patch fixing device for animal experiments and a method for using the same, so as to solve the problems that the existing patch fixing method cannot realize the standardization of the defect edge coverage distance, lacks objective tension control means, causes large differences in the adhesion of the patch and the abdominal wall tissue, and affects the stability of the regeneration and repair evaluation index due to the lack of operation consistency in animal experiments.

[0007] To achieve the above-mentioned purpose, the technical solution adopted by the present application is as follows: The present application provides a standard low-tension fixing device for animal experiments of soft tissue regeneration type hernia repair patches, comprising a ring-shaped positioner, a display screen, a tension adjusting assembly, and an adsorption fixing unit. The ring-shaped positioner is in a ring shape, and a plurality of U-shaped positioning notches are uniformly formed on the outer side wall thereof, and the positioning notches are arranged circumferentially along the ring-shaped positioner; a center positioning plate with a center is arranged at the center of the ring-shaped positioner, for aligning the center of the abdominal wall hernia defect, and the center positioning plate is fixedly connected to the inner wall of the ring-shaped positioner through a plurality of support rods. The display screen is arranged on the upper surface of the center positioning plate, for displaying numerical values in real time. The tension adjusting assembly comprises a suture needle holder, a tension sensor, a sliding block, and a sliding groove; the suture needle holder is slidably arranged inside the positioning notch, and the axis thereof is perpendicular to the center line of the positioning notch; the suture needle holder is connected with the tension sensor on the ring surface thereof, and the signal output end of the tension sensor is connected with the display screen through a wire; the suture needle holder is provided with a sliding block on both sides thereof, and the side wall of the positioning notch is provided with a sliding groove matched with the sliding block; the suture needle holder is slidably connected with the sliding groove along the length direction of the positioning notch; and a wire groove is formed on one side of the suture needle holder, for passing the suture line. The adsorption fixing unit comprises a plurality of groups of vacuum suction cups which are uniformly arranged circumferentially along the ring-shaped positioner; a ring-shaped air pipe is embedded on the inner side surface of the ring-shaped positioner; the top of the vacuum suction cup is connected with the ring-shaped air pipe through a connecting air pipe; a suction pipe is connected to the ring-shaped air pipe; a one-way valve is connected in series to the suction pipe; and the outer end of the suction pipe is connected to a manual negative pressure device; a vacuum pressure sensor is arranged on one group of vacuum suction cups; the monitoring end of the vacuum pressure sensor is inserted into the vacuum suction cup; and the signal output end of the vacuum pressure sensor is connected with the display screen through a wire.

[0008] Further, the ring-shaped positioner and the center positioning plate are both made of medical grade ABS material.

[0009] Further, the number of positioning notches is 12, and the included angle between adjacent positioning notches is 30°.

[0010] Further, the adsorption surface of the vacuum chuck is provided with a flexible silica gel pad, and micron-level anti-skid lines are arranged on the surface of the silica gel pad.

[0011] Further, the top of the vacuum chuck is further provided with a pressure relief valve for releasing the internal pressure of the vacuum chuck.

[0012] Further, the manual negative pressure device is a medical grade syringe, and the outer end of the air suction pipe is detachably connected with the syringe.

[0013] The application also provides a hernia repair patch fixing device for animal experiments and a use method thereof, comprising the following steps: Step 1: Assemble the device, check the connection of each part, and calibrate the sensor; Step 2: After the animal is anesthetized, lay the patch on the abdominal wall defect, and completely cover the abdominal wall defect; Step 3: Determine the center of the abdominal wall defect, cover the annular positioner on the animal abdominal wall hernia defect, press the patch, and adsorb the vacuum chuck on the edge of the abdominal wall defect, so that the center positioning plate is aligned with the center of the defect; confirm that the distance between the center positioning plate and the edge of the defect is equal, and adjust the position of the suction disc until the standard is met; Step 4: Insert the abdominal wall suture needle into the suture needle holder, penetrate the suture needle and the abdominal wall tissue, and adjust the tension of the suture needle holder to 1.2±0.2N through the display screen in real time, and complete the point suture; Step 5: Record the test data, open the pressure relief valve to remove the device after the test is completed, and check that the patch has no wrinkles and no deviation.

[0014] Further, in step 4, the suture needle holder is adjusted in position by sliding cooperation of the sliding block and the sliding groove, and the tension sensor feeds back the tension value in real time, so that tissue ischemia and necrosis caused by excessive tension or patch displacement caused by low tension are avoided.

[0015] Further, in step 5, the patch displacement distance is measured after 4 weeks of postoperative dissection, and the correlation between the fixation stability and the patch regeneration effect is analyzed in combination with the tension data.

[0016] Compared with the prior art, the application has the following beneficial effects: 1. The application realizes the technical breakthrough of the soft tissue regeneration hernia repair patch animal test fixing link through the "positioning-tension-operation" three-in-one standardized design, realizes the standardization of the patch covering the defect edge distance through the positioning slot and adsorption fixing unit of the ring positioning device, ensures that the patch covering distance deviation is less than or equal to 0.3 cm, and meets the requirement of "covering range at least 3 cm more than the defect edge" in the "soft tissue regeneration hernia repair patch animal test technical review points". Compared with the positioning deviation of 1-2 cm of the traditional manual suture, the positioning error of the application is reduced by more than 85%, which provides a unified positioning reference for different test batches and different operators, reduces the systematic error caused by positioning deviation, and makes the patch regeneration efficacy evaluation more objective.

[0017] 2. In the application, each positioning slot is equipped with a slidable suture needle holder with a built-in pressure sensor (range 0-5N), which is connected to an external display screen through a wire, and the tension value (accuracy ±0.1N) is displayed in real time. The operator can accurately adjust the tension by sliding the needle holder, and the suture tension is controlled at 1.2±0.2N (which can be corrected according to the animal weight), and the postoperative patch displacement distance is less than 0.5 cm, which avoids tissue ischemia caused by excessive tension or displacement caused by low tension; and the sensor data is recorded synchronously, which can be used to analyze the correlation between fixation stability and postoperative complications (such as serum edema), and provide objective evaluation for the test.

[0018] 3. The positioning stage aligns the center of the defect through the marker points, and the suture stage relies on the display screen to quantify the tension value, replacing the traditional "experience judgment" operation mode. The unified parameters of the device components (such as the size of the positioning device, the accuracy of the sensor, and the suction force of the suction cup) ensure the consistency of the operation in different test scenarios, improve the operation consistency, and are suitable for animal effectiveness evaluation of various soft tissue regeneration patches, eliminate the subjective judgment difference of different operators on "low tension state", reduce the group data fluctuation, and ensure the stability and reliability of the patch regeneration repair evaluation index (such as displacement amount and tissue integration rate).

[0019] Of course, any product implementing the present application does not necessarily need to achieve all the advantages described above. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiment description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creating any creative labor.

[0021] Fig. 1 It is a schematic diagram of the overall structure of the present application.

[0022] Fig. 2This is a top view of the present invention.

[0023] Fig. 3 This is a partial structural diagram of the present invention.

[0024] Fig. 4 This is a schematic diagram of the vacuum chuck in this invention.

[0025] Fig. 5 This is a schematic diagram of the ring positioner in this invention.

[0026] Fig. 6 This is a schematic diagram of the internal structure of the positioning slot in this invention.

[0027] In the diagram: 1. Syringe; 2. Suction tube; 3. Vacuum suction cup; 4. Connecting air tube; 5. Circular positioner; 6. Central positioning plate; 7. One-way valve; 8. Circular air tube; 9. Support rod; 10. Display screen; 11. Vacuum pressure sensor; 12. Pressure relief valve; 13. Positioning slot; 14. Suture needle holder; 15. Tension sensor; 16. Wire groove; 17. Slider; 18. Slide groove. Detailed Implementation

[0028] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0029] Example 1: As Figs. 1 to 6 As shown, a standardized low-tension fixation device for animal experiments of soft tissue regeneration hernia repair patch includes a ring locator 5, a display screen 10, a tension adjustment component, and an adsorption fixation unit.

[0030] The annular locator 5 has an annular structure with 12 positioning slots 13 evenly distributed on its outer wall. The included angle between adjacent positioning slots 13 is 30°. The positioning slots 13 are arranged around the circumference of the annular locator 5. A central positioning plate 6 is provided at the center of the annular locator 5 to align the center of the abdominal wall hernia defect. The central positioning plate 6 is fixedly connected to the inner wall of the annular locator 5 by several support rods 9 to ensure the stability of the central positioning plate 6.

[0031] The display screen 10 is located on the upper surface of the central positioning plate 6. The display screen 10 is a touch screen that supports real-time display of tension value and vacuum negative pressure value. It can automatically record and export data, with a storage time of ≥72h. The data can be exported via USB interface.

[0032] The tension adjusting assembly comprises a suture needle seat 14, a tension sensor 15, sliding blocks 17 and sliding grooves 18. The suture needle seat 14 is slidably arranged in the positioning notch 13, and the axis of the suture needle seat 14 is perpendicular to the center line of the positioning notch 13. The tension sensor 15 is connected to the surface of the suture needle seat 14, and the signal output end of the tension sensor 15 is connected to the display screen 10 through a wire. The sliding blocks 17 are arranged on the two sides of the suture needle seat 14, and the side wall of the positioning notch 13 is provided with the sliding grooves 18 matched with the sliding blocks 17. The suture needle seat 14 is slidably connected to the sliding blocks 17 and the sliding grooves 18, and can move along the length direction of the positioning notch 13. The suture needle seat 14 is provided with a wire groove 16 on one side, which is used for the passing of the suture line.

[0033] It should be noted that the tension sensor 15 is a strain type tension sensor 15, the range is 0-5N, and the accuracy is ±0.1N. The sensing end of the tension sensor 15 extends into the suture needle seat 14. When the suture line passes through the suture needle seat 14, it is in contact with the sensing end, and the suture tension data is collected in real time.

[0034] The adsorption fixing unit comprises three groups of vacuum suction cups 3 which are uniformly arranged along the circumference of the annular locator 5, and the material of the vacuum suction cups 3 is silica gel with a diameter of 1.5 cm. An annular air pipe 8 is embedded on the inner side of the annular locator 5. The top of the vacuum suction cup 3 is connected to the annular air pipe 8 through a connecting air pipe 4. The annular air pipe 8 is connected to an air suction pipe 2. A one-way valve 7 is connected in series to the air suction pipe 2. The flow direction of the one-way valve 7 is from the air suction pipe 2 to the manual negative pressure device, which prevents gas backflow and maintains the adsorption state of the vacuum suction cup 3 through the one-way valve 7. The outer end of the air suction pipe 2 is connected to the manual negative pressure device. A vacuum pressure sensor 11 is arranged on one of the groups of vacuum suction cups 3. The monitoring end of the vacuum pressure sensor 11 extends into the vacuum suction cup 3. The signal output end of the vacuum pressure sensor 11 is connected to the display screen 10 through a wire.

[0035] The range of the vacuum pressure sensor 11 is 0-20kPa, and the accuracy is ±0.5kPa.

[0036] The annular locator 5 and the center positioning plate 6 are made of medical grade ABS material. The diameter of the annular locator 5 is 8 cm, and the thickness is 0.5 cm.

[0037] The adsorption surface of the vacuum suction cup 3 is provided with a flexible silica gel pad. Micron-level anti-skid lines are arranged on the surface of the silica gel pad, which improves the adhesion and anti-skid effect of the vacuum suction cup 3 and the abdominal wall tissue.

[0038] A pressure relief valve 12 is further arranged on the top of the vacuum suction cup 3, which is used for releasing the internal pressure of the vacuum suction cup 3.

[0039] The manual negative pressure device is a medical grade syringe 1. The outer end of the air suction pipe 2 is detachably connected to the syringe 1. The air in the vacuum suction cup 3 is extracted through the syringe 1, so that the vacuum suction cup 3 is in a vacuum state, and the adsorption and fixation of the vacuum suction cup 3 are realized.

[0040] Embodiment 2: The present embodiment provides a method for using the above-mentioned device in a porcine abdominal wall defect model, the specific steps are as follows 1. Assemble the device, connect the syringe 1 with the air suction tube 2, check the connection of each part, calibrate the sensor, zero the tension sensor 15, calibrate the vacuum pressure sensor 11 to standard atmospheric pressure, and close the pressure relief valve 12 on the vacuum suction cup 3; 2. Select an adult pig with a body weight of 40 kg, construct a 4 cm diameter abdominal wall hernia defect model, expose the defect area after anesthesia, and disinfect the skin; select a soft tissue regeneration type hernia repair patch with a diameter of 8 cm, lay the patch on the abdominal wall defect, and cover the abdominal wall defect completely, and confirm that the edge of the patch exceeds the defect edge by 3 cm; 3. Determine the center of the abdominal wall defect, cover the annular positioner 5 on the animal abdominal wall hernia defect, align the center positioning plate 6 with the defect center, and press the patch; confirm that the center positioning plate 6 is equally distant from the defect edge, adjust the position of the suction cup until the standard is met; attach the three vacuum suction cups 3 to the abdominal wall skin, pull the syringe 1 piston to suck air, stop sucking air when the vacuum pressure sensor 11 displays a negative pressure value of 10 kPa, and confirm that the device is not displaced; 4. Insert the abdominal wall suture needle with suture line into the suture needle holder 14, and penetrate the edge of the patch and the abdominal wall tissue, slide the suture needle holder 14 to the target position, observe the tension value on the display screen 10, and adjust to 1.2±0.2N, according to the animal body weight, 1.0N for small pigs and 1.5N for large pigs, complete 12 needle sutures in turn; 5. After the suture is completed, the display screen 10 automatically records the tension value of each needle and the vacuum negative pressure value, and stores the data, after the test is completed, open the pressure relief valve 12 to remove the device, check that the patch has no wrinkles and no displacement.

[0041] During the suturing process, the suture needle holder 14 adjusts the position through the sliding block 17 and the sliding slot 18, and the tension sensor 15 real-time feedback tension value, to avoid tissue ischemia and necrosis caused by excessive tension or patch displacement caused by low tension.

[0042] After the suture is completed, dissect at 4 weeks after the operation, measure the displacement distance of the patch, and analyze the correlation between the fixation stability and the patch regeneration effect based on the tension data.

[0043] Specifically, the tension data analysis includes recording the suture tension value and tension fluctuation range during the operation, the mechanical properties of the patch after the operation (test strength and top breaking strength), histopathology (inflammatory cell infiltration degree, collagen content) and regeneration quality evaluation (regenerated tissue thickness and fibrosis degree), and performing correlation analysis, such as the correlation between the "intraoperative tension standard deviation" and the "postoperative tensile strength recovery rate" and the "collagen type I / III ratio", to predict the relationship between tension stability and biomechanics, that is, the smaller the tension fluctuation, the higher the tensile strength recovery rate, and the closer the tissue regeneration degree to the normal abdominal wall tissue.

[0044] The expected conclusions are: 1. Stable tension can promote orderly regeneration: the patch closely adheres to the host tissue without excessive traction, reduces ischemic inflammation, promotes orderly proliferation of fibroblasts and collagen remodeling (mainly type I collagen); 2. Unstable tension leads to regeneration disorder: repeated micro-motion of the patch causes chronic inflammation (macrophage persistent infiltration), inhibits angiogenesis, collagen is mainly type III (scarred repair), and the biomechanical properties decrease.

[0045] Obviously, the above embodiments of the present application are only examples for clearly illustrating the present application, and are not intended to limit the embodiments of the present application. For those skilled in the art, on the basis of the above description, other different forms of changes or variations can also be made, and it is impossible to enumerate all the embodiments here. Any obvious changes or variations derived from the technical solutions of the present application still fall within the protection scope of the present application.

Claims

1. A standardized low-tension fixation device for soft tissue regenerative hernia repair patch animal testing, characterized in that, The application relates to a hernia repair device, which comprises the following parts: a ring-shaped positioner (5) which is in a ring-shaped structure and is uniformly provided with a plurality of U-shaped positioning notches (13) on the outer side wall, the positioning notches (13) being arranged along the circumference of the ring-shaped positioner (5); a center positioning plate (6) is arranged at the center of the ring-shaped positioner (5) and is used for aligning the center of the abdominal wall hernia defect, the center positioning plate (6) is fixedly connected with the inner wall of the ring-shaped positioner (5) through a plurality of supporting rods (9); a display screen (10) which is arranged on the upper surface of the center positioning plate (6) and is used for displaying values in real time; a tension adjusting assembly which comprises a suture needle seat (14), a tension sensor (15), a sliding block (17) and a sliding groove (18), the suture needle seat (14) is slidably arranged in the positioning notch (13) and the axis of the suture needle seat (14) is perpendicular to the center line of the positioning notch (13); the suture needle seat (14) is connected with the tension sensor (15) on the ring surface, the signal output end of the tension sensor (15) is connected with the display screen (10) through a wire; the two sides of the suture needle seat (14) are provided with the sliding blocks (17), the side wall of the positioning notch (13) is provided with the sliding grooves (18) matched with the sliding blocks (17), the suture needle seat (14) is slidably matched with the sliding grooves (18) through the sliding blocks (17) and can move along the length direction of the positioning notch (13); one side of the suture needle seat (14) is provided with a wire slot (16) for the passing of a suture line; a suction fixing unit which comprises a plurality of groups of vacuum suction cups (3) uniformly arranged along the circumference of the ring-shaped positioner (5); a ring-shaped air pipe (8) is embedded on the inner side surface of the ring-shaped positioner (5), the top of the vacuum suction cup (3) is communicated with the ring-shaped air pipe (8) through a connecting air pipe (4), the ring-shaped air pipe (8) is connected with an air exhaust pipe (2), the air exhaust pipe (2) is connected with a one-way valve (7) in series, and the outer end of the air exhaust pipe (2) is connected to a manual negative pressure device; a vacuum pressure sensor (11) is arranged on one group of vacuum suction cups (3), the monitoring end of the vacuum pressure sensor (11) is inserted into the vacuum suction cup (3), and the signal output end of the vacuum pressure sensor (11) is connected with the display screen (10) through a wire.

2. The standardized low-tension fixation device for animal testing of soft-tissue regenerative hernia repair mesh according to claim 1, characterized in that: The ring-shaped positioner (5) and the center positioning plate (6) are made of medical-grade ABS material.

3. The standardized low-tension fixation device for animal testing of soft-tissue regenerative hernia repair mesh according to claim 1, characterized in that: The number of the positioning notches (13) is 12, and the included angle between adjacent positioning notches (13) is 30 degrees.

4. The standardized low-tension fixation device for animal testing of soft-tissue regenerative hernia repair mesh according to claim 1, characterized in that: The suction surface of the vacuum suction cup (3) is provided with a flexible silica gel pad, and the surface of the silica gel pad is provided with micron-level anti-skid lines.

5. The standardized low-tension fixation device for animal testing of soft-tissue regenerative hernia repair mesh according to claim 1, characterized in that: The top of the vacuum suction cup (3) is further provided with a pressure relief valve (12) for releasing the internal pressure of the vacuum suction cup (3).

6. The standardized low-tension fixation device for animal testing of soft-tissue regenerative hernia repair mesh according to claim 1, characterized in that: The manual negative pressure device is a medical-grade syringe (1), and the outer end of the air exhaust pipe (2) is detachably connected with the syringe (1).

7. A hernia repair patch fixation device for use in animal testing, based on the device of any of claims 1-6, characterized in that: The application further discloses a hernia repair method, which comprises the following steps: Step 1: assembling the device, checking the connection of each part, and calibrating the sensor; Step 2: after the animal is anesthetized, the patch is laid on the abdominal wall defect and covers the abdominal wall defect completely. Step 3: Determine the center of the abdominal wall defect, cover the ring-shaped locator (5) on the animal's abdominal wall hernia defect, press the patch, and adsorb the vacuum chuck (3) to the edge of the abdominal wall defect to align the center positioning plate (6) with the center of the defect; Confirm that the center positioning plate (6) is equally distant from the edge of the defect, adjust the position of the chuck until it meets the standard; Step 4: Insert the abdominal wall suture needle into the suture needle holder (14), penetrate the patch and abdominal wall tissue, adjust the tension to 1.2±0.2N by sliding the suture needle holder (14), monitor in real time through the display screen (10), and complete the suture; Step 5: Record test data, open the pressure relief valve (12) to remove the device after the test is completed, and check that the patch has no wrinkles or displacement.

8. The hernia mesh patch securing device for animal trials and methods of using same of claim 7, wherein: In step 4, the suture needle holder (14) adjusts the position through the sliding cooperation of the sliding block (17) and the sliding groove (18), and the tension sensor (15) feeds back the tension value in real time to avoid tissue ischemia and necrosis caused by excessive tension or patch displacement caused by low tension.

9. The hernia mesh patch securing device for animal trials and methods of using same of claim 7, wherein: In step 5, the patch displacement distance is measured after 4 weeks of postoperative dissection, and the correlation between fixation stability and patch regeneration effect is analyzed based on the tension data.

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