56 results about "Animal testing" patented technology

The invention discloses a traditional Chinese medicine composition for treating acute gout, an external gel and a preparation method thereof, and the traditional Chinese medicine composition comprises the following raw material components in parts by mass: 5-20 parts of radix clematidis, 5-20 parts of polygonum cuspidatum, 5-20 parts of honeysuckle stem, 5-15 parts of radix aconiti preparata, 5-15 parts of pine nodular branch, 1-5 parts of corydalis tuber and 1-3 parts of asarum. The gel disclosed by the invention is an external gel prepared by researching through a traditional Chinese medicine composition intermediate extraction process and a preparation forming process, has the effective effects of directly reaching an affected part, taking effect quickly, being good in patient compliance and the like, and can realize industrial production through pilot scale-up experiment verification. Animal experiment research results show that the radix clematidis pain-relieving gel has remarkable anti-inflammatory and pain-relieving effects.

The application relates to the field of biological medicine, and particularly discloses application of a sophora japonica extract in preparation of a product for improving the reproductive performance of ewes. The sophora japonica extract can effectively inhibit pyroptosis of ovarian granulosa cells by down-regulating expression of cysteine protease B, further reverses follicle atresia and ovulation disorders caused by pyroptosis, and improves the reproductive performance; animal experiments show that the sophora japonica extract can optimize the follicle development structure of ewes, inhibit overdevelopment of large follicles, and significantly improve the ovulation efficiency, thereby providing a new scheme for inhibiting pyroptosis of ovarian granulosa cells and improving the reproductive performance of livestock.

This invention discloses a coat-enhancing composition for improving the quality of cat fur and its application, belonging to the field of pet food technology. The composition uses a high proportion of fresh chicken meat and fresh bone-in chicken thigh meat as the main protein source, combined with krill oil, fresh chicken liver, various natural plant powders, and compound nutrients, formulated in a scientific ratio. Animal experiments have verified that this invention can significantly increase the amino acid content of cat fur, improve fur luster and saturation, enhance tensile strength, and optimize hair cuticle structure, without adversely affecting the cat's weight, blood routine, blood biochemistry, or other health indicators, demonstrating safety and high efficacy. This invention can be widely applied to the preparation of functional fresh meat baked food for improving the quality of cat fur.

The invention discloses blood filtration replacement liquid as well as a preparation method and application thereof. The displacement liquid comprises low molecular weight heparin calcium, prostaglandin E1, prostacyclin, electrolyte with specific concentration, glucose and an interleukin-1 receptor antagonist. The preparation method comprises the following steps: weighing the raw materials according to the proportion, dissolving to a constant volume, removing pyrogen and heat, and carrying out aseptic packaging. During clinical application, replacement liquid and blood are filtered according to the replacement rate of 1: 1-2: 1 according to the condition of a patient, 4-6 hours each time and 2-3 times each week, and related indexes are monitored. Animal tests show that the replacement liquid has good safety under the effective dosage, and has potential influence on part of organs under the high dosage. A stability test shows that the compound can be stably stored under a certain condition. The invention provides the replacement liquid which can achieve anticoagulation and blood vessel protection, maintain electrolyte balance and relieve inflammatory response, is expected to improve the prognosis of hemodialysis patients, and has important clinical significance and wide application prospects.

The utility model relates to the technical field of electric coagulation haemostatic forceps, and discloses a miniature electric coagulation haemostatic forceps for animal test surgery, which comprises two connecting rods, the left sides of the two connecting rods are fixedly connected with extension rods, the exteriors of the two extension rods are connected with sliding sleeves in a sliding manner, elastic assemblies are arranged in the extension rods, and the elastic assemblies are connected with the sliding sleeves in a sliding manner. A sliding groove is formed in the left side of the interior of the extension rod, a hemisphere is fixedly connected to the bottom of the elastic assembly, a plurality of clamping grooves are formed in the bottom side of the interior of the sliding sleeve, an outer clamp body is fixedly connected to the left side of one connecting rod, and an inner clamp body is fixedly connected to the left side of the other connecting rod. According to the haemostatic forceps, after the hemisphere moves to the designated clamping groove position, the spring releases elastic potential energy, the hemisphere is pushed to reset and be clamped in the clamping groove in the bottom of the sliding sleeve, and therefore the length of the haemostatic forceps is locked. The length of the hemostatic forceps can be flexibly adjusted according to the requirements of different operation scenes, and a doctor can operate and use the hemostatic forceps conveniently.

A therapy assembly can have an inner layer having an inner surface and an outer surface and defining a plurality of openings extending therethrough. The therapy assembly can also include a plurality of plates, each plate at least partially received within a respective opening of the plurality of openings of the inner layer. The therapy assembly can also include therapy circuitry including a cable having a plurality of electrical leads and a plurality of lead ends, each electrical lead electrically connected to a respective lead end of the plurality of lead ends. A cover layer can be attached to the outer surface of the inner layer and cover the plurality of lead ends of the cable. The plurality of lead ends can be in contact with a respective plate of the plurality of plates to define a plurality of electrodes.

The utility model discloses a small animal test post-operation wound surface shooting device, which comprises a base, a support vertical rod and an object placing table, the object placing table is arranged on the upper surface of the base, the support vertical rod is vertically fixed on the base, the support vertical rod is arranged on one side of the object placing table, a support arm assembly is arranged on the support vertical rod, and the support arm assembly is connected with the object placing table. Meanwhile, a clamping head assembly is arranged on the supporting arm assembly, a shooting instrument is clamped by the clamping head assembly, a fixing table assembly is installed on the object placing table, the device achieves effective constraint on shot living animals, the scale assembly is matched with the supporting vertical rod, the supporting arm assembly and the clamping head assembly, it is ensured that the proportions of images shot by different devices at different times are consistent, and the shooting efficiency is improved. The scale is used as a correction reference, the actual area of the wound surface can be automatically converted in software, the manual measurement error is reduced, the fixing table assembly and the fixing rod are designed in a modularized mode, 20-500 g experimental animals can be compatible, and the limitation of one mouse and one device of a traditional device is overcome.

Disclosed is a cage for animal experiments, comprising: an accommodation part providing a living space for laboratory animals; a cover part coupled to close an open surface of the accommodation part; and a photographing device mounting part provided on the outer surface of the cover part, wherein the photographing device mounting part comprises a guide rail extending along one direction of the cover part, and a grip part configured to secure the photographing device and mounted such that the position thereof can be adjusted with respect to the guide rail.

This invention discloses a high-pressure pneumatic rupture-type impact launcher for animal testing, belonging to the technical field of animal combat trauma simulation test equipment. The device includes a high-pressure air chamber, an air path adapter, a controllable on / off valve group, a short cavity, a diaphragm, and a diaphragm clamping and fixing structure. The high-pressure air chamber, air path adapter, and short cavity are sequentially connected. The diaphragm is installed on the end face of the short cavity through the clamping and fixing structure, forming a high-pressure ruptureable sealing structure. The device can be selectively equipped with sealing elements, a circular opening launch structure, and a square opening launch structure, enabling the simulation and preparation of various combat trauma models such as pure airflow impact, explosive shock wave, random combined injury from grenade explosion, high-speed precision projectile injury, and high-speed directional fragmentation injury. This invention features a compact structure, reliable sealing, and flexible operating condition switching. It can both reproduce the real random injury effects of the battlefield and achieve high-precision standardized injury testing, making it suitable for various animal combat trauma mechanism studies and protective effectiveness evaluations.

The invention discloses a feed additive for replacing antibiotics to treat chicken necrotic enteritis and application of the feed additive, and belongs to the technical field of feed. The effective component of the feed additive is the tannin extract from chestnut trees, and animal experiments prove that the tannin extract from chestnut trees can improve the production performance of broiler chickens with necrotic enteritis to a certain extent, improve the intestinal morphology and immune function of the broiler chickens with necrotic enteritis and improve the immunity of the broiler chickens with necrotic enteritis. Therefore, the chestnut tree tannin extract can replace antibiotics and has a good treatment effect on broiler intestinal inflammation caused by clostridium perfringens and coccidiosis.

The invention relates to the technical field of virtual reality, in particular to a multi-mode environmental animal test system and an olfactory stimulation component thereof, the olfactory stimulation component comprises a first gas channel, the first gas channel comprises an input section, a middle section and an output section which are connected in sequence; the first multi-way valve is arranged between the outlet of the input section and the inlet of the middle section; the second multi-way valve is arranged between the outlet of the middle section and the inlet of the output section; wherein the middle section comprises an air branch pipe and at least one sniffing branch pipe which are arranged in parallel, an inlet of the air branch pipe and an inlet of each sniffing branch pipe are connected to the first multi-way valve, and an outlet of the air branch pipe and an outlet of each sniffing branch pipe are connected to the second multi-way valve; the air branch pipe passes through the first mineral oil storage bottle, and each sniffing branch pipe passes through the sniffing bottle.

The invention belongs to the technical field of nano-antibodies, and particularly relates to a nano-antibody for resisting H1N1 influenza virus NA protein as well as a preparation method and application of the nano-antibody. The method comprises the following steps: by taking A / Puerto Rick / 8 / 34 (H1N1) influenza virus as a research object, purifying and inactivating the influenza virus through sucrose density gradient centrifugation, immunizing alpaca by taking the influenza virus as an immunogen, and screening by utilizing a phage display technology to obtain a high-affinity spectral anti-avian influenza virus NA protein nano antibody. Animal experiments show that the nano antibody has a good prevention effect when acting on A / Puerto Radio / 8 / 34 (H1N1) influenza virus infected C57 mice. Through preparation of the anti-influenza virus NA protein nano antibody, not only is a material provided for development of an H1N1 influenza virus diagnostic reagent, but also a thought is provided for identification of H1N1 subtype influenza virus epitope and vaccine design.

The application discloses Pediococcus pentosaceus SC009 and an application thereof, is preserved in the China General Microbiological Culture Collection Center, and has a preservation time of June 28, 2021 and a preservation number of CGMCC No.22796.The bacteria have the effects of promoting sleep and resisting oxidation, and can be used for preparing sleep-improving and oxidation-resisting food and sleep-disorder treating medicine.In animal experiments, the bacteria can significantly shorten the sleep latency of mice and prolong the sleep time length, improve the sleep quality of mice, significantly improve the total SOD and reduced glutathione content in serum of middle-aged and old rats, reduce the MDA and protein carbonyl content, and have significant antioxidant activity, and can prolong the survival time of old rats.Pediococcus pentosaceus SC009 has the effects of promoting sleep and resisting oxidation, is conducive to market popularization and utilization, and has a broad application prospect.

The present application relates to the field of microbial preparation, in particular to a probiotic composition beneficial to blood lipid health. The present application combines Bifidobacterium lactis MN-Gup, Bifidobacterium lactis M8, Lactobacillus plantarum LP6 and Lactobacillus casei PC01, and through animal experiment verification, can obviously reduce triglyceride and cholesterol in serum, and thus can be used for preventing and improving corresponding types of hyperlipidemia.

The invention relates to the technical field of virtual reality, in particular to an animal testing method and system based on virtual reality, and the method comprises the steps: displaying a virtual reality scene to an animal through a display unit; wherein the virtual reality scene comprises a visual stimulation pattern of a preset style in a preset display area; acquiring animal motion data provided by an animal motion device, and controlling the virtual reality scene to display a corresponding scene moving picture according to the animal motion data; if the animal reaches the preset functional object in the virtual reality scene, providing a corresponding feedback action to the animal through the animal interaction device according to the functional attribute corresponding to the preset functional object; and making animal behavior data acquired by an animal through an animal behavior acquisition device in the virtual reality scene display process into a file in a preset format, and outputting the file. The virtual reality scene is established and modified by using virtual display development software, and a user can easily use and expand the virtual reality scene without programming learning.

The application discloses a pet nutrition composition based on intestinal-brain axis regulation and application thereof, and the composition comprises 5-20% of probiotics, 10-25% of prebiotics, 2-10% of neurotransmitter precursors, 5-15% of anti-inflammatory and neurotrophic factors, 1-10% of plant extracts and the rest of carriers. The application remolds intestinal microecology by the synergy of probiotics and prebiotics, promotes the synthesis of 5-hydroxytryptamine and dopamine by neurotransmitter precursors, exerts the neuroprotective and anti-inflammatory effects by omega-3 fatty acids, vitamin B group and magnesium elements, realizes the anti-anxiety and tranquilizing effects by L-theanine, chamomile and lavender extracts, and forms a regulation link of multi-target point synergistic intervention of intestinal-brain axis. According to animal experiment verification, the application can significantly improve the anxiety behavior of pets, improve the content of fecal short-chain fatty acids, remodel the intestinal flora structure, and realize the synergistic effect of 'intestinal health-nerve regulation-behavior improvement'.

The application discloses a pig antigen-presenting cell targeting peptide and application thereof, and the amino acid sequence of the pig antigen-presenting cell targeting peptide is shown as SEQ ID NO. 1 or SEQ ID NO. 6. The FcMR specific 12-peptide sequence of the pig is screened by using a phage random display peptide library, the obtained FcMR specific 12-peptide sequence is fused with a model antigen for expression, and the FcMR specific 12-peptide sequence with the APC targeting property is further screened. In subsequent animal experiments, it is determined that the specific targeting peptide has an obvious enhancement effect on an immune response, and has important significance for the research and development of a future pig APC targeting drug.

The present application relates to the technical field of biotechnology, and particularly relates to an antibacterial and anti-inflammatory dual-activity polypeptide and application thereof.The amino acid sequence of the dual-activity polypeptide is shown as SEQ ID NO.1.The dual-activity polypeptide has good biocompatibility, can inhibit the growth of periodontitis pathogenic bacteria such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, inhibit the formation of bacterial biofilm, has high biological safety and no cytotoxicity, and can avoid bacterial drug resistance.The polypeptide can also prevent and treat periodontitis by reversing the phenotype of inflammatory cells and inhibiting the release of pro-inflammatory cytokines.Animal experiments show that the dual-activity polypeptide can effectively prevent and treat periodontitis, has great application value in the field of periodontitis treatment, and can also be used for the treatment of related bacterial flora infectious diseases and as a surface coating of implantable devices.

The invention discloses a traditional Chinese medicine composition for prevention and / or auxiliary prevention and treatment of digestive tract polyp and related tumors and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-30 parts of semen coicis, 4-10 parts of fructus mume, 0.5-1.5 parts of radix aconiti carmichaeli, 1-4 parts of stiff silkworm, 5-15 parts of herba patriniae, 1-4 parts of ground beeltle and 1-4 parts of aspongopus. Animal experiments prove that the traditional Chinese medicine composition disclosed by the invention has a remarkable effect on preventing and treating digestive tract polyps and related tumors, particularly colorectal polyps and related tumors.

Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a nasal preparation, its preparation method, and its application. This invention uses ferulic acid, an effector component obtained through extraction and purification of Ligusticum chuanxiong, as the active pharmaceutical ingredient, combined with pharmaceutical excipients, to prepare a traditional Chinese medicine nasal preparation for intranasal administration. Animal experiments have demonstrated that the nasal preparation provided by this invention has significant relieving and therapeutic effects on tension-type headaches. Furthermore, as a topical liquid preparation, the preparation is stable, non-irritating to the administration site, and exhibits good compliance, showing promising clinical application prospects. It represents a new option for nasal preparations in the field of traditional Chinese medicine for treating tension-type headaches.

The invention discloses a traditional Chinese medicine composition for treating functional dyspepsia with brain-intestine peptide disorder. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20-40 parts of codonopsis pilosula, 10-20 parts of poria cocos, 10-20 parts of Chinese yam, 5-15 parts of fingered citron, 10-15 parts of hawthorn and 2-8 parts of liquorice. Animal experiments prove that the traditional Chinese medicine composition disclosed by the invention has a remarkable effect in the aspect of treating functional dyspepsia with brain-intestine peptide disorder.

The application provides use of an S1PR1 biased agonist in preparation of a drug for treating inflammatory bowel disease. The application proves through animal tests that, compared with a dextran sodium sulfate treated inflammatory bowel disease model group of mice, the colon length of mice added with SAR247799 treatment tends to be normalized, and finally the purpose of treating inflammatory bowel disease is achieved, and the application has a practical popularization and application prospect.

The invention relates to the field of medicines, and particularly provides a ginger extract as well as a preparation method and application thereof, specifically, the ginger extract is extracted through a low-temperature extraction device, and animal experiments prove that the ginger extract can be used for treating diseases such as enteritis.

The utility model relates to the technical field of primate animal tests, in particular to a young monkey grip strength measuring device which comprises two vertical rods, a connecting rod and a measuring rod. The cross rod is detachably connected to the vertical rod, so that the cross rod is suspended; a display; wherein the cross rod comprises a first part and a second part, the first part of the cross rod is connected with the vertical rod, and a pressure detection component is arranged between the second part of the cross rod and the first part. On the basis of the structure of a horizontal bar, according to the characteristics that young monkeys are used to grasp branches, the cross bar is designed into two parts which are connected through the pressure sensor, after the young monkeys grasp the cross bar, the grabbing capacity of the young monkeys can be detected through the pressure sensor, the mode is very suitable for the grabbing force test of the young monkeys, use is easy, the operation difficulty can be reduced, and the test efficiency is improved. The time is saved, the research efficiency is improved, and especially the muscle strength, growth development and health state of the young monkey are evaluated according to test values.

The application discloses application of Clostridium cellabutyricum YQ-FP-027T in preparation of an agent for improving obesity, and belongs to the technical field of functional microorganisms, wherein the Clostridium cellabutyricum YQ-FP-027T is preserved in the China General Microbiological Culture Collection Center, and has a biological preservation number of CGMCC No.7.715. The Clostridium cellabutyricum YQ-FP-027T is a subtype of Clostridium cellabutyricum and is one of probiotics; it is verified through animal experiments that the Clostridium cellabutyricum YQ-FP-027T probiotic can improve the related symptoms of obesity induced by high-fat diet, such as reducing body weight, improving glucose tolerance and reducing insulin resistance level.

The application discloses a duck hepatitis virus 1 type DHAV-1 / HNSQ and application thereof, and belongs to the field of animal virology and genetic engineering. The duck hepatitis virus 1 type DHAV-1 / HNSQ has been preserved in the China Center for Type Culture Collection on March 5, 2026, and the preservation number is CCTCC NO:V202622. The VP1 gene of the variant strain has a deletion of three consecutive nucleotides. Animal experiments show that, after the variant strain infects ducklings, in addition to causing typical duck viral hepatitis lesions, the variant strain can also stably cause a new phenotype, such as thinning of the heart wall, reduction of myocardial toughness and liquefaction necrosis of pancreatic tissue, which has never been reported in the prior art, thereby providing important biological materials for effective prevention and control of duck hepatitis and pathogenic mechanism research.

The invention belongs to the technical field of biological medicines, and particularly relates to a Brucella recombinant multi-epitope vaccine and application thereof. The invention provides a recombinant multi-epitope vaccine protein of Brucella. The vaccine protein is a first vaccine variant rBMEV1 or a second vaccine variant rBMEV2. Results of embodiments prove that the vaccine provided by the invention can excite strong cross immune response aiming at main pathogenic species (such as sheep species, cattle species and pig species) of Brucella. Animal experiments prove that the antibody can induce a high-level and lasting specific antibody, can obviously activate response of CD4 + and CD8 + T cells and corresponding cell factors, and has good safety at the same time. According to the invention, the problems of narrow protection spectrum, dependence on exogenous adjuvants, single immune type and the like of the traditional brucella vaccine are solved, and a new generation of efficient, broad-spectrum and safe candidate vaccine strategy is provided for prevention and control of brucellosis.

The invention relates to a preparation method of a plateau highland barley extract for resisting skin aging and an application of the plateau highland barley extract in resisting skin aging. The preparation method comprises the following steps: performing enzymolysis on a crushed plateau highland barley raw material and simultaneously applying low-frequency ultrasonic-assisted extraction; inoculating a saccharomyces cerevisiae strain to the slurry subjected to enzymolysis for directional fermentation; centrifuging and ultra-filtering the fermentation liquor, mixing the extract and phospholipid in proportion to prepare liposome, and adding a preservative for stabilization; the problems that highland barley active ingredients are low in extraction rate, poor in stability and weak in skin penetration are solved. An oxidation test shows that the extract has strong antioxidant activity; animal experiments show that the extract can significantly increase the collagen content of the skin of old mice and has the effect of resisting skin aging; in-vitro cell experiments find that the extract significantly reduces the content of an aging marker beta-galactosidase, significantly increases the expression quantity of collagen, and can increase the content of antioxidant enzyme by increasing the activity of NRF2, and it is proved from the molecular level that the extract has a multi-dimensional skin anti-aging effect.