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Extraction method and application of moringa oleifera leaf total flavones

An extraction method and technology of Moringa oleifera leaves, which are applied in the field of extraction of total flavonoids from Moringa oleifera leaves, can solve the problems of insignificant therapeutic effect of Alzheimer's disease, large toxic and side effects, etc., achieve good application prospects, fast extraction speed, and protect blood vessels Effect

Inactive Publication Date: 2015-07-08
萧丽雅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the insignificant drug treatment effect of the prior art for hyperuricemia and senile dementia, the large defect of toxic and side effects, the object of the present invention is to provide a kind of extraction method and application thereof of total flavonoids of leaves of Moringa oleifera. Solve the above defects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027](1) Material preparation: weigh 1 kg of Moringa oleifera leaves, dry at 50°C for 2 hours, pulverize, pass through a 40-mesh sieve, and obtain Moringa oleifera leaf powder for later use;

[0028] (2) Extraction: take the Moringa oleifera leaf powder in step (1), add petroleum ether with a boiling range of 60-90°C twice the volume of the Moringa leaf powder mass, reflux and degrease at 68°C for 3 times, each time for 5 hours, Filter the filtrate, dry the filter residue, and obtain the dry filter residue for subsequent use;

[0029] (3) Extraction: Add 65% ethanol 10 times the volume of the filter residue to the dried filter residue obtained in step (2), heat for 8 minutes at a microwave power of 500W, and place it in a warm water bath at 75°C for ultrasonic extraction twice, each time for 30 minutes. Filter to obtain the extract, combine the extract to obtain the crude extract of total flavonoids of Moringa oleifera leaves;

[0030] (4) Purification: Add the crude extract...

Embodiment 2

[0032] (1) Preparation: Weigh 1 kg of Moringa leaves, dry them at 50°C for 2 hours, crush them, and pass through a 45-mesh sieve to obtain Moringa leaves powder for later use;

[0033] (2) Extraction: take the Moringa oleifera leaf powder in step (1), add 3 times the volume of the Moringa oleifera leaf powder mass of petroleum ether with a boiling range of 60-90 °C, reflux and degrease at 68 °C for 3 times, each time for 6 h, Filter the filtrate, dry the filter residue, and obtain the dry filter residue for subsequent use;

[0034] (3) Extraction: Add 70% ethanol 12 times the volume of the filter residue to the dried filter residue obtained in step (2), heat for 7 min at a microwave power of 600W, and ultrasonically extract twice in a warm water bath at 80°C, each time for 25 min, filter to obtain the extract, and combine the extract to obtain the crude extract of total flavonoids of Moringa oleifera leaves;

[0035] (4) Purification: Add the crude extract of total flavonoids...

Embodiment 3

[0037] (1) Material preparation: weigh 1 kg of Moringa oleifera leaves, dry at 50°C for 3 h, pulverize, pass through a 50-mesh sieve, and obtain Moringa oleifera leaf powder for later use;

[0038] (2) Extraction: take the Moringa oleifera leaf powder in step (1), add 4 times the volume of the Moringa oleifera leaf powder mass of petroleum ether with a boiling range of 60-90°C, reflux and degrease at 68°C for 3 times, each time for 7 hours, Filter the filtrate, dry the filter residue, and obtain the dry filter residue for subsequent use;

[0039] (3) Extraction: Add 75% ethanol 15 times the volume of the filter residue to the dried filter residue obtained in step (2), heat for 8 min at a microwave power of 550W, and ultrasonically extract in a warm water bath at 78°C for 3 times, each extraction 20 min, filter to obtain the extract, and combine the extract to obtain the crude extract of total flavonoids of Moringa oleifera leaves;

[0040] (4) Purification: Add the crude extr...

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Abstract

The invention belongs to the chemical field of natural products and in particular relates to an extraction method and an application of moringa oleifera leaf total flavones. The extraction method adopts microwave and ultrasound to synergistically extract the moringa oleifera leaf total flavones, and has the advantages of high efficiency, time saving, energy conservation, low energy consumption, simple operation and good repeatability. Besides, an animal test proves that the extracted moringa oleifera leaf total flavones have a significant treatment effect on hyperuricosuria and Alzheimer's disease. The total flavones provided by the invention can reduce uric acid, and can also reduce cholesterol, triacylglycerol, urea nitrogen, creatinine and xanthine oxidase, reduce the generation of uric acid, directly decompose uric acid, improve the renal function, promote uric acid excretion, and protect multiple levels of blood vessels to reduce uric acid, so that the moringa oleifera leaf total flavones are beneficial for healing of lithemia patients and have a broad medical application prospect.

Description

technical field [0001] The invention belongs to the field of natural product chemistry, and in particular relates to a method for extracting total flavonoids from leaves of Moringa oleifera and its application. Background technique [0002] Uric acid is a heterocyclic compound containing carbon, nitrogen, oxygen, and hydrogen. It is the final product of human purine metabolism and is usually catalyzed by xanthine oxidase. Under normal circumstances, the production and excretion of uric acid in the human body maintain a dynamic balance. If the production of uric acid is too much or the excretion is insufficient, the production and excretion of uric acid in the body will be unbalanced, which will lead to an increase in blood uric acid content, causing a series of complications, such as gouty arthritis, gouty nephropathy, gouty nephropathy, etc. Calculus, gouty heart disease, gouty hypertension and other serious complications seriously affect human health. [0003] With the im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P19/06A61P25/28
Inventor 严俊霖萧丽雅
Owner 萧丽雅
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