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Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity

a technology of composition and tobacco, which is applied in the field of composition for the use of snuff in the oral cavity, can solve the problems of not being able to avoid or reduce the release of potentially harmful and unwanted substances, unable to meet the needs of patients,

Inactive Publication Date: 2005-03-24
GALENICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a composition for oral use that allows for the controlled release of nicotine and other nicotine derivatives, while reducing the harmful substances in snuff. The composition includes a membrane material made of one or more membranes that are water-insoluble and water-permeable. The membrane material can be made of natural tobacco or a tobacco substitute, and may contain additional compounds such as sweeteners, aroma substances, and other taste additives. The membrane material can be made of synthetic or semi-synthetic membranes. The membrane material allows for the controlled release of nicotine and other nicotine derivatives, while reducing the harmful substances in snuff."

Problems solved by technology

Like the daily use of cigarettes, cigar, pipe and other smoke products, a daily use of snuff burdens the users body with a number of harmful compounds endogenous to tobacco.
The disadvantage of snuff is the vast number of compounds, more or less harmful to the body, e.g. different tobacco-specific nitrosamines, which are compounds known to cause different diseases such as, e.g., gastrointestinal disorders and cancer.
Both U.S. Pat. No. 5,346,734 and U.S. Pat. No. 6,162,516 do provide the user with a protective device to avoid a direct contact of the tobacco fibers in the snuff with the oral tissues, but no means have been taken in order to avoid or reduce the release of potentially harmful and unwanted substances.
Thus, potentially harmful and unwanted substances are still released from the tobacco into the oral cavity.
None of the above documents has solved the problems concerning eliminating or delaying the release in the oral cavity of unwanted and harmful substances when using a tobacco containing product as a snuff.

Method used

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  • Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity
  • Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity
  • Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity

Examples

Experimental program
Comparison scheme
Effect test

example 1

also shows that some hydrophobic membranes, e.g. vinyl and polyethylene membranes, have a slower nicotine release profile compared to the hydrophilic membranes.

All these observations make it possible to design membranes, which enable a specific release of nicotine, i.e. it is possible to design membranes having desired release characteristics e.g. a quick or a slow release of nicotine dependent on the purpose of the composition. In other words, the specific features of a membrane or a membrane material can be used to design a controlled and well-defined release profile for the release of nicotine from a composition according to the invention.

TABLE 2Release of nicotine from membranes of various kinds,thicknesses and pore sizesRelease of nicotine (%)Membrane0 min3 min30 min90 min120 min180 minReference filter4.718.746.580.888.8100(original)23 μm2.44.136.673.283.7100cellulose membrane13,000 MW cut-off46 μm cellulose1.62.433.369.179.2100membrane13,000 MW cut-off93 μm cellulose0017.24...

example 3

Optimization of Membrane Properties with Respect to Molecular Weight Cut-Off, Thickness and Low IPI Values

example 2

shows that no significant loss in membrane selectivity μs observed as the membrane thickness is being decreased. Therefore, further studies to investigate the relationship between membrane thickness, molecular weight cut-off of the membrane and amount of nicotine transferred over the membrane were performed by analyzing selected data from Example 1.

From FIG. 1, the maximum slope for each release profile has been deduced. The maximum slope, i.e. percentage nicotine release per time unit, dR / dt represents the maximum flux of nicotine through the membranes (see Table 4).

TABLE 4Values for the maximum flux (% nicotine released pertime unit, dR / dt) and lag time for different thicknesses ofmembranes with cut off 3500 Mw, 13000 Mw and reference filterMaximum fluxMolecular weightThicknessLag timeof nicotinecut-off(μm)(min)(dR / dt)∞01.250(reference pouch)13,000 MW CO23.201.205membrane46.401.14492.800.6373,500 MW CO25.2≈501.250membrane50.4≈501.204

FIG. 3 shows a plot of the maximum flux as a ...

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Abstract

A novel composition for the use as snuff in the oral cavity, the composition comprising tobacco and / or a tobacco substitute encapsulated in a membrane material comprising one or more membranes at least one of which being water permeable and water-insoluble. A novel composition enables a selective release of e.g. nicotine while it at the same time reduces the release of substances, which normally lead to unwanted side effects. The novel compositions may be used as a healthier alternative to snuff and other tobacco products such as, e.g., cigarettes, cigars and pipe. Methods for giving up smoking, reducing nicotine craving, reducing side effects normally related to smoking and snuffing of tobacco as welt a method for the preparation of a composition according to the invention.

Description

FIELD OF THE INVENTION The present invention relates to a novel composition for the use as snuff in the oral cavity, the composition comprising tobacco and / or a tobacco substitute encapsulated in a membrane material comprising one or more membranes at least one of which being water permeable and water-insoluble. A novel composition enables a selective release of e.g. nicotine while it at the same time reduces the release of substances, which normally lead to unwanted side effects. The novel compositions may be used as a healthier alternative to snuff and other tobacco products such as, e.g., cigarettes, cigars and pipe. The invention also relates to methods for giving up smoking, reducing nicotine craving, reducing side effects normally related to smoking and snuffing of tobacco as well to a method for the preparation of a composition according to the invention. BACKGROUND OF THE INVENTION The use of tobacco is deeply rooted in a large part of the world population. In the Scandin...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A24B13/00A24B15/16
CPCA24B15/16A24B13/00
Inventor HANSSON, HENRIHOVGAARD, LARSSPEGEL, CHRISTER
Owner GALENICA
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