38 results about "Senile dementia" patented technology

The application belongs to the technical field of disease risk prediction, and discloses a computer network-based risk prediction system for senile dementia, which comprises the following steps: collecting multi-modal data of a target user to obtain social interaction data, physiological parameter data and cognitive behavior data; extracting cognitive fluctuation nodes, social degradation nodes and physiological disorder nodes through dynamic fluctuation feature analysis to form a potential key node feature set; constructing an individualized dementia conversion risk map based on time sequence correlation and cross-modal coupling characteristics of the potential key node feature set to identify key risk nodes; determining a risk inflection point and predicting a senile dementia risk grade by analyzing the topological structure change and time evolution mode of the dementia conversion risk map; and providing a personalized risk intervention scheme and monitoring intervention effects in real time; the application realizes early and accurate prediction and active intervention of dementia risk, and significantly improves prevention efficiency and clinical decision value.

The invention provides a senile dementia early diagnosis method based on hippocampus magnetic resonance imaging, which comprises the following steps that: according to a segmented image, a contour extraction algorithm is adopted to obtain multi-layer two-dimensional contour data to obtain a contour sequence, and the contour extraction algorithm carries out gradient analysis and threshold filtering on geometric features of a hippocampus, and captures boundary details; the contour sequence is subjected to space alignment processing, an alignment contour set is obtained, displacement deviation between different layers is eliminated through a transformation correction method in the space alignment processing, and the alignment contour set is generated; calculating volume and morphological indexes according to the preliminary three-dimensional model, and determining the atrophy degree; and comparing the refined three-dimensional structure with a preset reference model to generate difference mapping, judging the diagnosis precision, and adopting a geometric feature deviation measurement method to evaluate the structural difference in comparison to generate the difference mapping. According to the method, the fidelity and diagnosis precision of three-dimensional reconstruction of the hippocampus are remarkably improved, and reliable technical support is provided for early diagnosis of neurodegenerative diseases.

This invention discloses a low-allergen compound oral liquid for middle-aged and elderly people that protects the liver, stabilizes blood pressure, blood sugar, and blood lipids, combats aging, aids sleep, and prevents Alzheimer's disease. It belongs to the field of food and medicine homology health food technology. The invention uses kudzu root extract, Japanese raisin tree fruit extract, mulberry leaf extract, jujube seed saponins, Acer truncatum seed oil (nervonic acid), blueberry anthocyanins, bitter melon small molecule peptides, wolfberry polysaccharides, γ-aminobutyric acid, and chrysanthemum flavonoids as core active ingredients, refined with a prebiotic system. This invention achieves comprehensive conditioning effects for middle-aged and elderly people through the synergistic action of five pathways: liver protection and metabolism, vascular regulation, anti-oxidation and anti-aging, nerve calming, and brain nerve repair. It simultaneously nourishes and protects the liver, stabilizes blood pressure, blood sugar, and blood lipids, delays aging, improves intractable insomnia, enhances memory, slows brain atrophy, and prevents Alzheimer's disease. This formula strictly avoids eight common allergens, is pure and mild, and contains no irritating additives, making it suitable for long-term use by middle-aged and elderly people with weak constitutions. This product is an oral liquid formulation, with small molecule extraction, strong permeability, rapid absorption, low gastrointestinal burden, stable production process, and high safety. It has extremely high clinical promotion value and industrialization prospects.

The invention discloses a dietary therapy formula for preventing senile dementia, improving memory, repairing a conducted nervous system and dredging damaged brain nerves, and belongs to the technical field of dietary therapy health care. According to the formula, functional nutritional ingredients, bioactive peptides, medicinal and edible extracts and compound probiotics are taken as cores, and the formula is prepared through scientific proportioning; the health-care food specifically comprises xylitol, isomaltooligosacharide, N-acetylneuraminic acid, phosphatidylserine, bovine brain peptide, walnut peptide, shark peptide, acer truncatum seed oil microcapsule powder, DHA algal oil microcapsule powder, spina date seeds, tea theanine, gamma-aminobutyric acid, Belgian imported inulin, magnesium stearate, and 16 optional specific probiotics and metabiotics. The formula follows a multi-dimensional synergistic principle of nutrition supply-nerve repair-function regulation-absorption synergy, the core component can penetrate through a blood brain barrier, supplement nerve repair raw materials, repair damaged nerve cells and myelin sheaths and regulate neurotransmitter balance, and the probiotics indirectly assist nerve maintenance through intestinal tract-nerve axis, so that the composition has the effects of promoting blood circulation and promoting blood circulation. The synergistic effects of preventing senile dementia, improving memory and repairing and dredging a nervous system are achieved; the raw materials are food-grade safe components, have no side effects, can be prepared into powder, tablet candies and other forms, are convenient to eat and suitable for long-term conditioning, and solve the problems of single component, insufficient repair pertinence and low absorption efficiency of existing nerve care products.

The present invention relates to a class of monoclonal antibodies having anti–von Willebrand factor (VWF) effects, and a use thereof. A pharmaceutical composition of the monoclonal antibodies or antigen-binding fragments having anti–von Willebrand factor effects provided by the present invention can be used to reduce VWF levels in the body, thereby preventing and treating thrombotic microangiopathies having various causes (including thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, and atypical hemolytic-uremic syndrome), cardiovascular disease, stroke, atherosclerosis, senile dementia, vascular dementia, and bacterial and viral infectious diseases.

The application discloses a kind of American ginseng compound antioxidant products, is prepared from the following mass fraction components extraction: American ginseng 20-30 parts, 15-25 parts of radix rehmanniae preparata, 20-28 parts of dogwood, 15-25 parts of radix scrophulariae, 15-25 parts of gardenia, 8-12 parts of safflower, 18-22 parts of chuanxiong, 20-26 parts of citrus aurantium, 18-25 parts of alocasia, 10-20 parts of polygala, 16-26 parts of Platycladus branchlet, 15-25 parts of hovenia dulcis thunb, after screening, cleaning, crushing, weighing, alcohol extraction, water extraction, concentration and the like step is made.Compared with prior art, the application obtains the beneficial effect: synergistic effect between components, by tonifying qi and invigorating the spleen, nourishing liver and kidney, clearing heart and detoxifying, promoting blood circulation and qi movement, it has the effect of root and original for senile dementia, using reasonable extraction method is beneficial to the extraction of each effective component;Since the components of the application are non-toxic commonly used medicinal materials, there is no harm to the body after use, and there is no side effect.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to application of brostallicin sodium in preparation of a drug for treating senile dementia. The application relates to application of brostallicin sodium in treatment of senile dementia. The application establishes a dementia model of a dementia rat and a dementia mouse through an in-vivo experiment, and establishes a PC12 cell, a BV2 cell and a HT22 cell damage model through an in-vitro experiment, and finds that brostallicin sodium has a prevention and treatment effect on senile dementia. The brostallicin sodium is expected to be used as a preparation of a drug for treating senile dementia for clinical application.

The application discloses a sesquiterpene dimer and a preparation method and application thereof, and belongs to the technical field of natural compound extraction. According to the preparation method, dried sesquiterpene dimers are extracted by refluxing with 95% ethanol, and then petroleum ether and ethyl acetate are used for extraction to obtain an extract, which can be obtained by column chromatography and semi-preparative high performance liquid chromatography, so that the method is simple, time and labor are saved, and the yield is higher. The obtained sesquiterpene dimers have high anti-neuritis activity, and have important application prospects for developing new drugs for treating senile dementia.

The structure of the water-soluble prodrug of dexcamphanol or fenchol accords with a general formula (I), wherein R1 is-H, R2 is alkyl with 1-3 carbon atoms, and R3 and R4 are-H or-CH3. The compound provided by the invention has good water solubility and can be used for preparing medicines for treating cerebral apoplexy or senile dementia.

The invention relates to the technical field of positioning bracelets, in particular to a positioning bracelet for preventing senile dementia patients from getting lost, which comprises a positioning bracelet body, two mounting blocks are fixedly connected to two sides of the positioning bracelet body, and two connecting blocks are fixedly mounted on opposite sides of the two mounting blocks. A mounting groove with an opening in one side is formed in each of the two connecting blocks, four sliding grooves are formed in the two sides of each mounting groove, through the arrangement of the mounting grooves, under the sliding limiting effect of the sliding grooves and the sliding blocks, when the watchband is damaged, family members can quickly replace the positioning wristband for the old, the mounting safety of the wristband is improved, and the practicability of the wristband is improved. Meanwhile, by means of standby batteries arranged on the two sides of the positioning bracelet, endurance charging can be effectively carried out when the main battery is out of power, meanwhile, by means of an external solar piece, charging endurance can be carried out through light energy after the old man gets lost, the situation that the bracelet is out of power and cannot be used is avoided, and the efficiency of finding the old man is improved.

The invention discloses a ganoderma lucidum preparation for treating Parkinson's disease and application thereof, relates to a medicine, and provides the ganoderma lucidum preparation for treating Parkinson's disease, the ganoderma lucidum preparation comprises ganoderma lucidum hawthorn spore powder and ganoderma lucidum spore oil, the weight ratio of the ganoderma lucidum hawthorn spore powder to the ganoderma lucidum spore oil is (1-2): (1-2), and the weight ratio of the ganoderma lucidum hawthorn spore powder to the ganoderma lucidum spore oil is (1-2): (1-2). In the anti-senile dementia process, it is known that ganoderma lucidum has the protection effect on nerve cell mitochondria, nerve cell axons, nerve cell short processes and the like of a central nervous system, and has the effect of promoting growth of nerve cells of the central nervous system, and the effect is opposite to the pathological development of Parkinson's disease.

Disclosed in the present invention are aza-fused ring compounds, and a pharmaceutical composition and the use thereof. The structure of the compounds is shown as formula I. The compounds can effectively inhibit ASM activity, wherein under a micromolar concentration level, the enzyme inhibition rate reaches 100% optimally and the enzyme inhibition IC50 value thereof is lower than 5 nM optimally. The compounds can exert pharmaceutical effects at all of the molecular level, the cell level and the animal level, and exhibit excellent therapeutic effects, and have application prospects in treating ASM-related diseases, e.g. depression, senile dementia, cognitive disorders, stroke, myocardial ischemia, pulmonary fibrosis, chronic obstructive pulmonary diseases, pulmonary injury, pulmonary arterial hypertension, respiratory distress syndrome, cystic fibrosis, fatty liver, liver fibrosis, autoimmune diseases, tumors and diabetes.

The invention belongs to the technical field of natural medicines and pharmacology, and particularly relates to a raspberry extract as well as a preparation method and application thereof. Aiming at the problems of brain fatigue and functional hypomnesia caused by high-intensity brainwork of middle-aged and young people below 50 years old in the modern society, the invention provides a preparation process of a targeted enriched active monomer, which comprises the following steps: by taking dried raspberry fruits as a raw material, firstly, carrying out reflux degreasing with n-hexane to remove fat-soluble impurities; and sequentially extracting the degreased filter residues step by step by using ethanol with different concentrations, combining extracting solutions, and concentrating and drying to obtain the traditional Chinese medicine composition. The extract obtained by the preparation process can remarkably improve dysmnesia induced by scopolamine and inhibit the activity of acetylcholin esterase, is suitable for preparing products for relieving mental fatigue and improving learning efficiency, and does not relate to treatment of degenerative diseases such as senile dementia.

The utility model relates to the technical field of medical instruments. The novel senile dementia rapid test reagent box for screening comprises a storage box, a plurality of test tube racks used for placing test reagents are arranged in the storage box, a plurality of placing grooves are formed in the surfaces of the test tube racks, a cover plate is installed above the storage box, and a writing board is installed on the side face of the storage box through a rotating shaft. A moving groove is formed in the lower portion of the writing board, a moving column is slidably arranged in the moving groove, a moving plate is arranged at the position, below the placing groove, of the side face of the moving groove, and through the sliding design of the moving groove and the moving column, linkage with a reagent lifting mechanism is achieved, and a reagent tube can be lifted; the reagent bottle is stably extruded and limited by the limiting assembly below the cover plate under the action of the elastic element, so that the leakage or damage of the reagent in the transportation or storage process is effectively prevented, and the durability and reliability of the kit are improved.

The invention belongs to the technical field of health monitoring, and particularly relates to a senile dementia risk home monitoring method based on multi-modal behavior analysis, which comprises the following specific steps: monitoring human body postures in real time, analyzing repeated actions, synchronously early warning abnormal movement, and carrying out voice interaction operation through a built-in AI dialogue terminal; performing behavior, emotion and physiology correlation modeling, executing cognitive decline dynamic evaluation through cognitive function self-test, and judging a risk level according to an analysis and evaluation result; executing a multi-level early warning mechanism based on the risk level information, and automatically taking corresponding emergency measures; the threshold value is dynamically calibrated by integrating user habit data, a closed-loop feedback mechanism is designed to realize false alarm suppression, and a monthly health report is synchronously generated to assist a doctor in adjusting an intervention scheme. The problems that in a traditional monitoring mode, tiny behavior changes are difficult to capture, rescue is delayed due to subjective evaluation hysteresis and passive response, the screening frequency is low, and the scene is limited can be solved.

The application discloses a bacterial agent for preventing senile dementia and belongs to the technical field of microorganisms. The Weizmannia coagulans A921 is screened, has relatively wide antibacterial property on the basis of excellent acid tolerance and bile salt tolerance, has a good relieving effect on Alzheimer's disease, and can improve behavioral characteristics and biochemical indexes. Further, the Weizmannia coagulans A921 is compounded with Weizmannia coagulans S511, a Weizmannia coagulans compound bacterial agent with a better effect than a single strain is obtained, and the Weizmannia coagulans compound bacterial agent has a wide application prospect in the preparation of anti-Alzheimer's disease products.

The application discloses a cognitive training device for preventing senile dementia and application thereof and belongs to the field of brain training. The device comprises a training table, a training mechanism and an exercise mechanism arranged on the upper side of the training table, and a memo board fixedly connected to the upper side of the training table. The training mechanism comprises a cushioning block fixedly connected to the upper side of the training table, and the upper side of the cushioning block is provided with a mounting plate. The device can not only train the cognition of the old people, but also train the memory of the old people when the brain of the old people is exercised. The family members or medical staff can only observe on one side without participating in the brain exercise of the old people when accompanying the old people. The training mechanism and the exercise mechanism are arranged so that the family members or medical staff can easily help the old people to exercise the brain, and the brain exercise of the old people is interesting and simple. The memo board can be used for recording important matters or the exercise conditions of the old people by the family members or medical staff.

A substituted 3-fluorobenzenepropanoate compound represented by formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate (such as a hydrate) thereof, a clathrate thereof, a racemate thereof, a co-crystal thereof, an isotopic label thereof, or a nitrogen oxide thereof, as well as pharmaceutical compositions and uses thereof. The compound has significantly elevated drug activity, and can effectively treat and / or prevent inflammation, pain, fever, cancer, or senile dementia.

The present application provides a kind of composition for treating senile dementia and its preparation method.The composition is composed of Cistanche and other multi-flavor Chinese medicinal materials, and is used for treating mild and moderate senile dementia, and is suitable for popularization and application.

The present application relates to a kind of steroid compound and its application in treating neurodegenerative diseases, the steroid compound has the structure shown in formula I: The steroid compound of structure I is isolated from the whole grass of Solanum nigrum by yeast fermentation for the first time, it shows better neurotrophic factor (NGF) activity and acetylcholinesterase inhibitory activity, is expected to be developed as the drug or functional food of neurotrophic and neuroprotective function, for treating neurodegenerative diseases (such as senile dementia).

The application belongs to the technical field of medicine, and particularly relates to a pharmaceutical composition for treating senile dementia and application thereof. The application provides a pharmaceutical composition containing (Z)-3-(N-(3-bromo-4-fluorophenyl)-N'-hydroxyl formamido)-4-(2-guanidinoethyl)amino)-1,2,5-oxadiazole and icariin. Pharmacodynamic experiments prove that the pharmaceutical composition of the application achieves a synergistic therapeutic effect in treating senile dementia.

The invention relates to cordyceps sinensis galactomannan polysaccharide as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical analysis. The polysaccharide is composed of galactose (Gal), mannose (Man) and glucose (Glc); the mass ratio of galactose to glucose to mannose in the polysaccharide is (29-32): (11-14): (55-58). The polysaccharide has excellent cellular immunocompetence and medicinal activity of preventing and / or treating cancers, resisting oxidation, whitening, resisting saccharification, reducing blood fat, reducing blood sugar, reducing uric acid or preventing and / or treating senile dementia and the like.

4-alkoxy-substituted 2,6-dihydroxybenzoic acid ester compound of d-camphor or fenchol, the structure conforms to general formula (I) wherein: R 1 is or R 2 is -H, -NO2; R 3 alkyl of 1-4 carbon atoms or the compound has good anti-inflammatory effect, and can be used for preparing drugs for treating inflammation-related diseases or stroke injury, cerebral edema, senile dementia.

The invention belongs to the technical field of biology, and discloses a yak yogurt-derived pediococcus acidilactici strain with neuroprotection and anti-dementia functions as well as a metagen and application of the yak yogurt-derived pediococcus acidilactici strain, the name of the yak yogurt-derived pediococcus acidilactici strain is MNSR144, the classification name is pediococcus acidilactici, the preservation number is CGMCC NO.37266, the preservation date is January 4, 2026, and the preservation number is CGMCC NO.37266. The strain is preserved in China General Microbiological Culture Collection Center (CGMCC), No. 3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing. The invention finds that pediococcus acidilactici MNSR144 and the metaplast thereof can realize nerve injury protection and prevention and treatment of dementia diseases through anti-inflammatory action, experiments are carried out by using the pediococcus acidilactici MNSR144, and the experiments show that the strain and the metaplast thereof can reduce the content of IL-1beta, IL-6 and TNF-alpha in brain tissues of mice with senile dementia, improve neuroinflammation and prevent and treat dementia diseases, so that the pediococcus acidilactici MNSR144 and the metaplast thereof can be used for preventing and treating dementia diseases. Therefore, the effect of preventing senile dementia is achieved.

The invention relates to the technical field of red ginseng preparation, in particular to a preparation method of a red ginseng product capable of preventing senile dementia, and the raw material formula comprises the following components: red ginseng, Chinese wolfberry fruit extract, walnut peptide, vitamin E, maltodextrin and magnesium stearate. The components and the proportion are as follows: the proportion of the red ginseng is 40 parts; the matching ratio of the fructus lycii extract is 15 parts; the ratio of the walnut peptide is 10 parts; the proportion of the vitamin E is 2 parts; the proportion of the maltodextrin is 31.5 parts; the proportion of the magnesium stearate is 1.5 parts; the processing technology comprises the following steps: step 1, pretreating raw materials; 2, strengthening extraction of effective components of red ginseng; step 3, mixing multiple components; step 4, granulating and forming; and step 5, packaging and inspecting. The invention aims to solve the problems that the crushing and grinding degree of red ginseng is insufficient, the compact tissue structure of red ginseng is difficult to fully break, the dissolution efficiency of subsequent effective components is influenced, and part of active components are oxidized and degraded.

The invention relates to a bicyclic micromolecule TNF-alpha inhibitor as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The invention provides a variety of bicyclic small molecule compounds, or pharmaceutically acceptable salts thereof, or solvates thereof, or isomers thereof, and pharmaceutical compositions containing the bicyclic small molecule compounds, or pharmaceutically acceptable salts thereof, or solvates thereof, or isomers thereof. The invention also provides a preparation method of the bicyclic small-molecule compounds and application of the bicyclic small-molecule compounds as TNF-alpha small-molecule inhibitors. Based on the fact that the bicyclic small-molecule compounds can be used as TNF-alpha small-molecule inhibitors, the bicyclic small-molecule compounds, or pharmaceutically acceptable salts, solvates or isomers thereof, can be used as TNF-alpha small-molecule inhibitors. The invention also relates to a pharmaceutical composition containing the compounds, which has good potential for treating immune diseases such as ulcerative colitis, Crohn's disease, rheumatoid arthritis, osteoarthritis, psoriasis, systemic lupus erythematosus, lupus nephritis and the like, as well as brain diseases such as neurodegenerative diseases, senile dementia and the like, and has good economic value and social significance.

The invention discloses a composition containing three plant lactobacillus plantarum strains and application of the composition, the composition comprises the plant lactobacillus plantarum AUSA002, the plant lactobacillus plantarum AUSA004 and the plant lactobacillus plantarum FL001, and the preservation numbers of the plant lactobacillus plantarum AUSA002, the plant lactobacillus plantarum AUSA004 and the plant lactobacillus plantarum FL001 in the Guangdong Microbial Culture Collection Center (CDMCC) are GDMCC.No64417, GDMCC.No64418 and GDMCC.No64420 respectively. The composition provided by the invention has the effects of synergistically improving learning memory and cognitive impairment and preventing senile dementia, and also has the effect of improving gastrointestinal functions.

The invention relates to the technical field of senile dementia prevention, in particular to a plant drink which is used for preventing senile dementia and comprises 10-30 parts by weight of folium ginkgo, 15-25 parts by weight of Chinese yam, 10-20 parts by weight of radix astragali, 8-15 parts by weight of radix salviae miltiorrhizae and 5-10 parts by weight of poria cocos, and each raw material comprises active ingredients. The natural, safe and easy-to-take plant drinking liquid is prepared by selecting the following medicinal materials such as ginkgo leaves, Chinese yam, astragalus membranaceus, salvia miltiorrhiza, poria cocos and the like, proportioning the medicinal materials and extracting active ingredients of the medicinal materials, can effectively improve memory and delay cognitive function decline, and has a prevention effect on senile dementia.

The invention discloses a sesquiterpene dimer as well as a preparation method and application thereof, and belongs to the technical field of natural compound extraction. According to the preparation method, the dried sesquiterpene dimer is subjected to reflux extraction with 95% ethanol and then extracted with petroleum ether and ethyl acetate to obtain the extract, the extract can be obtained through column chromatography and semi-preparative high performance liquid chromatography, the method is simple, time and labor are saved, and the yield is higher. And the obtained sesquiterpene dimer has high anti-neuritis activity, and has an important application prospect for developing a new medicine for treating senile dementia.

The present invention relates to new uses of a 5-HT4 receptor agonist, specifically Isopropyl-3 - { 5- [ 1 -(3 - methoxypropyl) piperidin-4-yl] - [ 1,3,4] oxadiazol-2-yl } - 1 H- indazole (Compound- 1) or a pharmaceutically acceptable salts thereof, for the treatment of dementia due to menopause, senile dementia, cognitive deficits associated with schizophrenia, depression, chemotherapy-induced cognitive impairment and behavioural and psychological symptoms of dementia such as apathy / indifference, agitation, aggression, depression, anxiety, irritability / lability, dysphoria, aberrant motor behaviour, delusions, hallucinations, elation / euphoria, psychosis, disinhibition, sleep and night time behaviour disorders or appetite and eating disorders. The present invention further provides use of the said compounds in the manufacture of medicament intended for the treatment of the disorders described herein.