25 results about "Sea-squirt" patented technology

The invention relates to a traditional Chinese medicine preparation for treating gastritis and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 40-50 parts of a traditional Chinese medicine composition, 10-15 parts of a sustained release agent, 25-32 parts of a filling agent and 3-8 parts of a flavoring agent, the slow release agent is modified carboxymethyl konjac glucomannan; the filling agent is cordyceps militaris polysaccharide and lactose; the flavoring agent is aspartame or sucralose. The sustained release agent is neohesperidin dihydrochalcone modified carboxymethyl konjac glucomannan, neohesperidin dihydrochalcone has the effect of inhibiting gastric acid secretion, and neohesperidin dihydrochalcone and the traditional Chinese medicine ingredient cuttlebone can synergistically play a role in preparing acid and jointly play a role in protecting gastric mucosa. Meanwhile, the cordyceps militaris polysaccharide has polysaccharide generality of thickening and stable film forming, and forms a compact network structure together with the modified carboxymethyl konjac glucomannan, and the obtained traditional Chinese medicine preparation has a good slow release effect.

The application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound preparation for treating solid tumors and promoting blood circulation to remove blood stasis and a preparation method and application thereof. Under the guidance of traditional Chinese medicine theory, according to the syndrome manifestations of patients with solid tumors (early, middle and late stages), the traditional Chinese medicine compound preparation prepared from the animal traditional Chinese medicines gecko, sea squirts and leeches and the plant traditional Chinese medicines notoginseng, madder, safflower and licorice in a certain proportion is used to treat patients with blood stasis syndrome of malignant tumors, can obviously improve the life quality of the patients, reduce the toxic and side effects of radiotherapy and chemotherapy, prolong the survival period of the patients and improve the symptoms of blood stasis syndrome of the patients.

The invention discloses application of plasmalogen in assisting in gaining muscle and reducing fat in aerobic exercise and relieving skeletal muscle and kidney injury caused by exercise, and belongs to the technical field of biological medicine. According to the invention, a model of mouse skeletal muscle and kidney injury caused by exhaustion movement is established in vivo, and skeletal muscle and kidney injury is relieved by intervention of a sea squirt phospholipid extract and sea squirt plasmalogen respectively. Skeletal muscle injury and metabolic waste entering blood of a C57BL / 6J mouse caused by continuous exhaustion exercise for 7 days greatly increase the kidney burden. The sea squirt phospholipid extract and the sea squirt plasmalogen relieve muscle and kidney injury caused by exhaustive exercise and improve exercise performance.

The invention belongs to the technical field of micro-plastic adsorbents, and provides a micro-plastic enriched fiber as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out microfluidic spinning on a sea squirt cellulose solution to obtain sea squirt cellulose nanocrystalline fibers; the preparation method comprises the following steps: modifying an MXene suspension to obtain modified MXene, and dispersing the modified MXene in water to obtain a modified MXene suspension; and soaking the sea squirt cellulose nanocrystalline fiber in the modified MXene suspension. The micro-plastic enriched fiber disclosed by the invention has excellent micro-plastic adsorption performance, nano-scale micro-plastics in a complex environment can be efficiently captured, and the adsorption capacity reaches 845.1 mg / g; the microplastic-enriched fiber can enhance a signal of a Raman spectrum to 5 times of the original signal, so that not only is the detection sensitivity improved, but also quantitative analysis of microplastics can be realized, the accuracy and reliability of a detection technology are improved, and the microplastic-enriched fiber is suitable for being used in a non-laboratory environment.

This invention discloses a micro-pneumatic artificial muscle based on a phase transition hydrogel actuator, its preparation method, and its application, belonging to the field of polymer functional materials technology. The method includes the following steps: (1) using octyl acrylate and acrylamide as monomers, dissolving the monomers, β-cyclodextrin, and crosslinking agent in a dimethylformamide dispersion of sea squirt cellulose nanocrystals, followed by the addition of a photoinitiator to obtain a prepolymer; the prepolymer is then photocured and solvent-replaced to obtain a tubular hydrogel; (2) connecting one end of the tubular hydrogel to an air cavity and sealing the other end to obtain a micro-pneumatic artificial muscle based on a phase transition hydrogel actuator. This method has the advantages of convenient processing, mild reaction, and readily available materials. The micro-pneumatic artificial muscle prepared by this method has adjustable mechanical properties independent of water permeability and fast driving speed, and has broad application prospects in miniaturized biomimetic soft robot devices.

This invention discloses a temperature- and pressure-sensitive, high-strength, and tough multifunctional nanocomposite hydrogel and its preparation method, belonging to the field of hydrogel technology. The invention first isolates tunicin from sea squirts and hydrolyzes it with acid to obtain sea squirt nanocellulose. Hydroxypropyl cellulose is dissolved in deionized water, sodium dodecyl sulfate is added, and the mixture is sonicated until dissolved. Then, octadecyl methacrylate, acrylamide, sea squirt nanocellulose suspension, and MXene / Ag nanosheet dispersion are added sequentially, and the mixture is mixed with an initiator. Emulsion polymerization is then performed to obtain the nanocomposite hydrogel product. The reaction disclosed in this invention is easy to operate and operates under mild conditions. Furthermore, the nanocomposite hydrogel prepared by the method disclosed in this invention exhibits high efficiency in multiple sensitivities (temperature and pressure), high strength, and excellent biocompatibility, showing broad application prospects in disease diagnosis and daily monitoring in the medical and pharmaceutical fields.

The invention relates to the technical field of sea squirt culture, and particularly discloses a full-artificial culture system for ciona intestinalis, a seawater preparation unit is used for purifying tap water and adding sea salt to adjust the salinity of simulated seawater; the culture unit comprises a culture pond, a seawater supply system and a drainage system; the culture pond is made of a transparent material, the seawater supply system conveys prepared seawater to the culture pond through a pipeline, and the drainage system is used for regularly replacing and discharging wastewater in the culture pond; the seawater circulating unit is used for purifying seawater in the culture system and promoting circulating flow of water in the culture system; the temperature control unit is used for controlling constant water temperature in the culture pond; the illumination control unit is used for simulating natural light to irradiate the sea squirts. By means of the artificial seawater circulation system, dependence on natural seawater is completely eliminated, and full-artificial breeding of ciona ciona is achieved. According to the system, internal circulation operation is achieved, waste of water resources is reduced, and meanwhile the risk of environmental pollution is reduced.

The invention belongs to the technical field of gene engineering, and particularly relates to an NRPS gene, a vector and construction and preparation of a high-yield cyclic dipeptide compound recombinant strain of the NRPS gene. According to the invention, an NRPS core gene is excavated from a sea squirt-derived fungus Diapothesp.SYSU-MS4722, a recombinant strain is constructed by using the gene and using Aspergillus oryzae as a heterologous expression host, the cyclic dipeptide natural product cyclo (Phe-Ala) is successfully separated, and the yield can reach 110 mg / L, which is increased by 20 times compared with the yield of cyclo (Phe-Ala) in reported marine bacteria Pseudomonasputida. Therefore, the aspergillus oryzae recombinant strain disclosed by the invention can be used for efficiently preparing the cyclic dipeptide compound cyclo (Phe-Ala) and has an important application value.

The invention provides a biological prevention and control method for typical fouling organisms in a southern mariculture net cage and application of the biological prevention and control method. The main idea is as follows: firstly, finding out community composition and space-time change rules of fouling organisms in a sea area, secondly, investigating main fishes in the sea area, determining bait organism composition of the main fishes, selecting fingerlings which can ingest target fouling organisms and meet cage culture conditions, and finally, carrying out culture tests. The biological control effect of the fishes on the target fouling organisms is verified. The invention further provides a method for clearing away the sea squirts attached to the southern mariculture net cage by using the feeding habit of the siganus giganteus, the problem that a large amount of manpower and material resources are consumed in a traditional sea squirt clearing technology is effectively solved, and culture environment damage caused in the traditional sea squirt clearing process is reduced; and the influence on the cultured object in the netting replacement process is reduced, so that the economic loss in the culture period is reduced. A foundation is laid for establishing a biological prevention and control sea squirt model, and the method has a very good application value in natural seawater cage culture.

The present invention belongs to the field of biomaterial preparation technology, and specifically relates to a sea squirt nanocellulose-enhanced rapid hemostatic sponge with photothermal antibacterial effect and a preparation method thereof. The present invention uses chitosan and oxidized konjac glucomannan as matrix materials, nano sea squirt cellulose and polydopamine nanoparticles as main reinforcing raw materials, firstly modifies konjac glucomannan into oxidized konjac glucomannan by oxidation, and constructs sea squirt nanocellulose / polydopamine polysaccharide-based scaffold material, which not only has a good infrared light response antibacterial effect, but also has a uniform three-dimensional macroporous structure that enables the sponge scaffold to achieve the function of rapid hemostasis, and can effectively scavenge free radicals and promote wound healing. The prepared sponge has good biocompatibility and no cytotoxicity, and is expected to become a new type of rapid hemostasis and effective antibacterial scaffold material.

The application belongs to the technical field of adsorbing materials, and particularly relates to a sepia cuttle pyrolysis derived adsorbing material and a preparation method and application thereof. The sepia cuttle pyrolysis derived material provided by the application has a calcium carbonate matrix with a porous house frame type pore channel structure and an organic carbon film covering the surface of the calcium carbonate skeleton and the pore channel wall, can realize synchronous removal of heavy metals and eDNA in water, exhibits high removal efficiency on composite pollutants in water, and is more convenient for recycling due to the block structure.

The invention discloses a drug delivery process anomaly detection method based on a sea squirt group optimization algorithm. The method comprises the following steps: S1, generating a multi-mode drug delivery process time sequence-space data cube; s2, segmenting the multi-modal drug delivery process time sequence-spatial data cube into a multi-scale patch set according to a preset time window length and a spatial sensing domain size; s3, constructing a sea squirt group optimization algorithm search structure to obtain an optimal multi-scale parameter combination; s4, constructing a multi-scale anomaly detection model based on the sea squirt group optimization algorithm and MLP-Mixer fusion; s5, obtaining a trained multi-scale anomaly detection model; s6, forming a post-fixation multi-scale anomaly detection model; s7, identifying an abnormal event set in the drug delivery process; and S8, constructing a process quality feedback control loop based on the identified abnormal event set in the drug delivery process, mapping an abnormal type and a confidence score into a control instruction of the drug delivery equipment, driving the drug delivery equipment to execute dose dynamic compensation, delivery path re-planning or emergency pump stop operation, and realizing closed-loop steady-state regulation and control in the drug delivery process. According to the invention, the average omission ratio in low-density anomaly identification is reduced.

This invention belongs to the field of seahorse farming technology and discloses a feed additive that promotes the growth of striped seahorses and its application. Specifically, it discloses a feed additive comprising carotenoids, sea squirt powder, oyster powder, mannan oligosaccharides, probiotics, and vitamins. This invention provides a feed additive containing carotenoids, sea squirt powder, oyster powder, mannan oligosaccharides, probiotics, and vitamins. Adding this feed additive to seahorse feed can significantly promote seahorse growth (significantly increasing weight gain rate, specific growth rate, and body length growth rate) and improve seahorse survival rate. This feed additive not only helps improve the economic benefits of seahorse farming but also provides strong technical support for the sustainable development of the seahorse farming industry.

Turbinmicin, an isolated compound of Formula I or IA is provided. Turbinomycin compounds of Formula II or IIA are also provided. A compound isolated from a bacterial species from the sea squirt, Ecteinascidia turbinate, and having a chemical formula of C34H29NO11 is also provided. Compositions including turbinmicin and turbinmicin compounds, such as pharmaceutical compositions including effective amounts of turbinmicin or turbinomicing compounds for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with turbinmicin, turbinmicin compounds and compositions thereof are disclosed.

The invention relates to the technical field of medicine, in particular to a multifunctional cuttlebone microneedle patch and a preparation method thereof. The multifunctional cuttlebone microneedle patch provided by the invention is composed of a needle body layer and a backing layer. The needle body layer is loaded with cuttlebone decalcified powder and silver nanoparticles; and the backing layer is made of chitosan hydrogel. The multifunctional cuttlebone microneedle patch provided by the invention has good biological activity, can continuously release silver ions (Ag < + >) and active ingredients, can remarkably inhibit related bacteria in vitro, prolong antibacterial aging and promote cell proliferation, migration and vascularization, and in-vivo results show that the patch can accelerate wound healing, promote collagen deposition and blood vessel maturation and relieve inflammation.

The application discloses a sea squirt siphon blood pressure reducing oligopeptide with angiotensin converting enzyme (ACE) inhibitory activity and a preparation method and application thereof, the amino acid sequence of the blood pressure reducing oligopeptide is Phe-Cys-Arg-Leu-His-Pro (FCRLHP), and the ESI / MS detection molecular weight is 771.93 Da. The sea squirt siphon is crushed, ultrasonically pretreated, enzymatically hydrolyzed, ultrafiltered, gel chromatographically purified, and RP-HPLC purified to obtain the blood pressure reducing oligopeptide Phe-Cys-Arg-Leu-His-Pro (FCRLHP). The active peptide Phe-Cys-Arg-Leu-His-Pro (FCRLHP) prepared by the application has significant angiotensin converting enzyme (ACE) inhibitory activity and human umbilical vein endothelial cell (HUVEC) protection effect, and can be developed as a hypertension treatment drug and an auxiliary treatment product.

The invention belongs to the technical field of medicines, and particularly relates to structural optimization, preparation and application of a sea squirt-derived compound Hermanine D. The invention further discloses a preparation method of the sea squirt-derived compound Hermanine D. The gouty arthritis is caused by sodium urate (MSU) crystal deposition and inflammatory disorder, and due to the limitation of the existing therapy, the gouty arthritis is always a treatment problem. The research of the invention focuses on the marine biological alkali, namely, the Hermanine D (HDD) extracted from the Hermania momus (Hermania momus). Through structure-function relationship (SAR) research and computational modeling optimization, the binding capacity of the polypeptide and a peroxisome proliferator-activated receptor gamma (PPAR-gamma) is remarkably enhanced, and the receptor is a key regulatory factor of a PPAR-gamma / NF-kappa B signal channel in gout pathogenesis. The optimized HDD derivative 9a not only shows strong PPAR-gamma binding affinity and pharmacokinetic characteristics, but also can effectively inhibit proinflammatory cytokines driven by NF-kappa B in an in-vitro experiment. In a mouse MSU-induced gouty arthritis model, the 9a obviously relieves synovitis and tissue damage. The action mechanism is that PPAR-gamma is activated to inhibit NF-kappa B, and the assembly of NLRP3 inflammasome is blocked.

The application discloses a multifunctional polyvinyl alcohol-based hydrogel and a preparation method and application thereof, and belongs to the technical field of high polymer hydrogel material preparation.The hydrogel takes polyvinyl alcohol (PVA) as a base material, takes polydopamine-coated sea squirt nanocellulose (PDA@TCNCs), beta-glycerophosphate sodium (GP) and phytic acid (PA) as functional components; the mass-volume ratio of PVA, PDA@TCNCs, GP and PA aqueous solutions is 2.62g:0.05g-0.25g:1.0g:4mL-12mL.The hydrogel has excellent mechanical properties, anti-swelling properties and antibacterial properties, and has good biocompatibility, and has wide application prospects in wearable strain sensors, underwater motion monitoring and triboelectric nanogenerators and other fields.

The application provides a tissue extract for inducing settlement metamorphosis of sea squirt larvae, and belongs to the field of amino acid substance functions. Sea squirt or shellfish tissue is ground and centrifuged to obtain supernatant; trichloroacetic acid is added and the mixture is placed at low temperature; the supernatant is then centrifuged; the supernatant after centrifugation is evaporated, and the obtained precipitate is dissolved in a solvent to obtain the tissue extract. The tissue extract can be applied to induce settlement metamorphosis of sea squirt larvae.

The invention provides a composition for reducing pearl shell fouling organisms and a preparation method and application thereof, and belongs to the technical field of mariculture. The antifouling composition disclosed by the invention is prepared from the following raw materials in parts by mass: 15 to 25 parts of pseudoalteromonas leavening, 8 to 15 parts of macleaya cordata total alkali, 5 to 10 parts of acorus calamus essential oil and 10 to 20 parts of carboxymethyl chitosan. Through compounding of the pseudoalteromonas leavening, the macleaya cordata total alkali, the acorus calamus essential oil and the carboxymethyl chitosan, a remarkable synergistic anti-fouling effect is achieved, the synergistic coefficient Q is larger than or equal to 1.25, and the anti-fouling effect is far better than the sum of the single use effects of all the components; broad-spectrum anti-fouling of common fouling organisms for pearl shell culture such as barnacles, ciona glabra, coelpipe worms and bryozoon is achieved, the anti-fouling rate is larger than or equal to 93%, and the actual anti-fouling requirement for pearl shell culture is met.

The invention relates to the technical field of ciona ciona breeding, and particularly discloses a ciona ciona full-artificial breeding method which is carried out according to the growth stage and comprises the following steps: firstly collecting mature ciona ciona gametes for artificial insemination, and culturing fertilized eggs by using filtered seawater containing antibiotics in a specific ratio; then floating / swimming larvae are screened, cleaned, subjected to multi-round state judgment and antibiotic replacement and transferred to a breeding tank through suspension culture, water is replaced every day, and dead individuals are observed and removed; subsequently, according to different stages of larvae, adults, sexually mature adults and aged adults, the culture time, the feeding frequency and the bait dosage are adjusted; in the sexual maturity stage, self-fertilization embryos need to be collected in a specific photoperiod. By means of the method, ciona glabra can be efficiently cultivated, the survival rate of all stages is guaranteed, and technical support is provided for large-scale cultivation of ciona glabra.

The application discloses a full-life-cycle green type sea tunic collagen-based antibacterial film and a preparation method thereof. Marine fouling organism, i.e., a real sea tunic, is used as a raw material for preparing the collagen film, and the preparation process mainly comprises the following steps: destroying the hydrogen bond between the closely gathered collagen fibers in the tissue through a strong polar hydrogen bond breaker, i.e., a urea solution, and mechanical action, obtaining micro-nano-sized collagen fibers, then performing suction filtration on the suspension, quickly obtaining a collagen fiber film, and then soaking the film in a chitosan solution, and finally preparing the collagen-based antibacterial film. The material has a short preparation time, only involves urea and sodium chloride reagents in the preparation process, and the urea solution generated in the experiment process can be naturally air-dried and recycled through evaporation crystallization. The collagen-based antibacterial film meets the sustainable development concept from the selection of raw materials, to the processing and preparation process, to the disposal of the product after use, and is a full-life-cycle green type food packaging film.

The invention discloses a traditional Chinese medicine composition for treating gastroesophageal reflux. The invention belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from rhizoma bletillae, bulbus fritillariae thunbergii, cuttlebone, calcined concha arcae, fructus amomi and the like. The traditional Chinese medicine composition has the effects of relieving hyperacidity and pain, and regulating qi and harmonizing stomach. The traditional Chinese medicine composition disclosed by the invention has an excellent clinical effect in treating the gastroesophageal reflux disease, is mild in medicine property of the whole formula, is suitable for various syndromes of the gastroesophageal reflux disease, and is particularly suitable for patients with heartburn, sour regurgitation and belching, chest distress, inappetence, vomiting, throat discomfort, light red tongue, white fur and slippery pulse caused by phlegm-heat and qi stagnation.

The present application relates to the technical field of path planning, and especially relates to a robot path planning method based on an improved sea squirts colony model, which comprises the following steps: establishing a navigation point map model, constructing a mobile robot path cost function and a collision cost function with the shortest path as a target, constructing an improved sea squirts model, and obtaining optimal path points by using the improved sea squirts model. The present application establishes a model with the shortest path as a target function model, and the model is free of collision obstacles. The original algorithm is improved by means of chaotic initialization of initial sea squirts colony, increase of inertia weight, and non-uniform mutation, so as to balance the algorithm development and exploration efficiency. Finally, the improved sea squirts optimization algorithm is combined with cubic spline interpolation, so as to better complete the robot path planning problem.