34 results about "Nanocomposite hydrogels" patented technology

The invention belongs to the technical field of biological materials, and particularly relates to nano composite hydrogel as well as a preparation method and application thereof. In the preparation process of the hydrogel, preparation of gelatin hydrazide and preparation of pullulan oxidation are sequentially completed, then preparation of active component loaded PLGA nanoparticles and self-assembly coating with metal-polyphenol are completed, and finally, the metal-polyphenol coated PLGA nanoparticles are mixed with gelatin hydrazide and pullulan oxidation to form gel in situ. The hydrogel has the characteristics of injectability, self-healing, wet adhesion and the like, the metal-polyphenol layer has the effects of resisting inflammation, resisting oxidation and promoting angiogenesis and generates photo-thermal response to near infrared rays, on-demand controllable release of the drug-loaded nanoparticles is achieved, the composite hydrogel can improve the wound surface microenvironment, promote angiogenesis and inhibit inflammation and scar formation, and the drug-loaded nanoparticles can be applied to wound healing. The ointment is suitable for burns, scalds and various complex wounds.

The invention discloses nano composite hydrogel modified silica gel as well as a preparation method and application thereof. The method comprises the following steps: (1) preparing carbon nanoparticles; (2) preparing a polyvinyl alcohol aqueous solution and a pre-polymerized solution of carbon nanoparticles and hydrogel; (3) preparation of nano-composite hydrogel modified silica gel: adding the pre-polymerized liquid and silica gel into the polyvinyl alcohol aqueous solution under stirring, adding an initiator, carrying out hot bath, carrying out condensation reflux in an inert atmosphere for reaction, and then adding a polyvinyl alcohol cross-linking agent and an HCl aqueous solution for reaction; and after the reaction is finished, centrifugally washing and drying to obtain the nano-composite hydrogel modified silica gel. The nano-composite hydrogel modified silica gel has excellent hydrophilicity, can be used as a hydrophilic mode liquid chromatography filler, and has great development space and application potential in the field of chromatographic separation and analysis.

The invention relates to the technical field of biological materials, and discloses a preparation method of novel antibacterial nano composite hydrogel for repairing diabetic oral ulcer. Comprising the following steps: grafting 2-formylphenylboronic acid on titanium carbide (MXene) nanosheets to form MXene (at) FPBA nanoparticles, carrying out an amidation reaction on lipoic acid and recombinant collagen to obtain modified recombinant collagen, doping the MXene (at) FPBA into the modified recombinant collagen system, and carrying out photo-crosslinking to obtain the novel antibacterial nano composite hydrogel. The hydrogel combines the strong anti-oxidation and anti-inflammatory capabilities of lipoic acid, does not need to add anti-inflammatory drugs, and also has good adhesiveness; the MXene (at) FPBA nano particles can be used for capturing bacteria and carrying out efficient sterilization; and the raw materials used by the material have biological safety. Therefore, the hydrogel has the antibacterial property and the anti-inflammatory function, and can comprehensively and efficiently manage and treat diabetic oral ulcer wounds.

The invention provides biological nano composite hydrogel as well as a preparation method and application thereof, and the preparation method of the biological nano composite hydrogel comprises the following steps: dissolving VVPS and beta-CD in a NaOH aqueous solution, heating to 60-63 DEG C, and stirring for more than 30 minutes until the VVPS and the beta-CD are completely dissolved; slowly adding PEGDGE into the solution, continuously stirring until the cross-linking agent is dissolved, raising the temperature to 65 DEG C or above, and reacting for 4 hours or above to form hydrogel; and performing swelling treatment on the hydrogel, drying, soaking in an ethanol water solution containing capsaicin for more than 48 hours, filtering, and performing freeze drying. The biological nano composite hydrogel prepared by the preparation method disclosed by the invention has good application in delivery of capsaicin and alleviation of type II diabetes mellitus.

The invention provides a preparation method of acacia gum nano-composite hydrogel. The preparation method comprises the following steps: S1, mixing an acacia gum aqueous solution with a free radical initiator, and then sequentially adding acrylonitrile, CuFe2O4 nanoparticles and a cross-linking agent into the mixture to obtain the acacia gum nano composite hydrogel. The acacia gum nano-composite hydrogel combines the characteristics of a natural polymer, a synthetic polymer and inorganic nanoparticles, and is an effective adsorbent for removing heavy metals in an aqueous solution, the prepared magnetic hydrogel is treated by hydroxylamine hydrochloride, so that a nitrile group is converted into an amidoxime group to serve as a bidentate ligand, and the adsorption capacity of the hydrogel is improved. The existence of CuFe2O4 in the acacia gum nano-composite hydrogel makes the recoverable magnetic hydrogel possible, the recoverable magnetic hydrogel can be easily removed from an aqueous solution and regenerated, and after three continuous cycles, the recoverable magnetic hydrogel still has high heavy metal adsorption capacity.

The application discloses a kind of low modulus high ductility super-retarding concrete, the concrete includes by weight ratio: cement 254~360 parts, fly ash 68~108 parts, slag powder 68~70 parts, 5~16mm gravel 352~393 parts, 16~25mm gravel 660~729 parts, medium sand 669~705 parts, rubber powder 20 parts, polystyrene plastic 15 parts, water 150 parts, water reducing agent 5.9~7.5 parts, super-retarding agent 3.1~4.0 parts, water-based polyurethane 15 parts, nano composite hydrogel 15 parts, polyolefin elastomer 5 parts, polypropylene fiber 1.0 part, can have higher toughness, lower elastic modulus, and can reach design requirement strength and durability, simultaneously, when practical application, first, a layer of low modulus high ductility super-retarding concrete is poured, then continue to pour ordinary concrete, combined with other anti-cracking measures, can effectively reduce the constraint degree of bottom plate to upper portion, prevent temperature cracks.

The application relates to a sizing agent for rayon and a preparation method thereof, which comprises the following components in mass fractions: 900-1100 parts of methyl acrylate, 100-140 parts of acrylic acid, 110-150 parts of methyl methacrylate, 340-380 parts of acrylonitrile, 330-340 parts of ethanol, 2.5-3 parts of mercaptan, 130-150 parts of sodium dodecyl benzene sulfonate, 1.5-2.5 parts of whiting, 280-300 parts of smoothing agent, 18-20 parts of antistatic agent, 13-17 parts of bactericide, and the balance of water; and further comprising a nano composite hydrogel, wherein the nano composite hydrogel comprises L-arginine, silicotungstic acid, acrylic acid and a modified montmorillonite system. The application has the effects of improving the flexibility and wear resistance of the sizing agent for rayon.

The application discloses a temperature-sensitive nanocomposite hydrogel for extinguishing and preventing re-ignition of lithium iron phosphate batteries and a preparation method thereof, and relates to the technical field of battery extinguishing and re-ignition prevention. First, a phase change heat storage microcapsule material is prepared by taking a dodecahydrate sodium hydrogen phosphate solution, an alkali compound and an ethanol solution of tetraethyl orthosilicate as raw materials; then, polyphosphoric acid-amino acid polymer is prepared by adding arginine into an ethanol solution of polyphosphoric acid; finally, the temperature-sensitive nanocomposite hydrogel is prepared by adding the phase change heat storage microcapsule material and the polyphosphoric acid-amino acid polymer into a hydrophilic gel material. The temperature-sensitive nanocomposite hydrogel has the comprehensive advantages of efficient extinguishing, rapid cooling and persistent re-ignition prevention, and the temperature-sensitive nanocomposite hydrogel reduces economic losses caused by lithium ion battery fires by combining physical cooling, chemical inhibition and physical isolation.

This invention discloses a temperature- and pressure-sensitive, high-strength, and tough multifunctional nanocomposite hydrogel and its preparation method, belonging to the field of hydrogel technology. The invention first isolates tunicin from sea squirts and hydrolyzes it with acid to obtain sea squirt nanocellulose. Hydroxypropyl cellulose is dissolved in deionized water, sodium dodecyl sulfate is added, and the mixture is sonicated until dissolved. Then, octadecyl methacrylate, acrylamide, sea squirt nanocellulose suspension, and MXene / Ag nanosheet dispersion are added sequentially, and the mixture is mixed with an initiator. Emulsion polymerization is then performed to obtain the nanocomposite hydrogel product. The reaction disclosed in this invention is easy to operate and operates under mild conditions. Furthermore, the nanocomposite hydrogel prepared by the method disclosed in this invention exhibits high efficiency in multiple sensitivities (temperature and pressure), high strength, and excellent biocompatibility, showing broad application prospects in disease diagnosis and daily monitoring in the medical and pharmaceutical fields.

An elastomeric nanocomposite hydrogel includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles. The elastomeric nanocomposite hydrogel is cytocompatible, and, upon degradation, produce substantially non-toxic products.

The invention discloses a nano composite hydrogel based on phase engineering 1T-MoSe2 as well as a preparation method and application of the nano composite hydrogel. The nano composite hydrogel comprises a temperature-sensitive hydrogel matrix, and the < 1 > T-MoSe2 nanosheets are dispersed in the hydrogel matrix. The hydrogel loaded with the 1T-MoSe2 nanosheets is used for preparing the medicine or dressing for treating the diabetic chronic wounds, the dressing can generate a large amount of ROS and generate the photothermal effect under the combined stimulation of exogenous ultrasound (US) and near-infrared light (NIR), and the hydrogel has efficient photothermal response and ROS generation capacity and can be used for preparing the medicine or dressing for treating the diabetic chronic wounds. Low-concentration hydrogen peroxide can be catalyzed to generate a large amount of hydroxyl radicals (. OH), and the broad-spectrum sterilization effect on various bacteria is achieved in combination with the photothermal effect; when no exogenous stimulation exists, inherent SOD and CAT-like enzyme activity is shown, excessive active oxygen is removed, the oxidative stress state of the wound surface is effectively relieved, polarization of macrophages to M2 anti-inflammatory phenotypes is promoted, and control over the inflammatory state is achieved.

The preparation method comprises the following steps: carrying out surface modification and uniform dispersion treatment on aramid fibers to prepare an aramid nanofiber dispersion liquid; adding the aramid nanofiber dispersion liquid into the polyacrylamide prepolymerization solution, and uniformly stirring to obtain a mixed solution; and carrying out in-situ polymerization treatment on the mixed solution to obtain the nano-composite hydrogel, adding metal salt to endow the hydrogel with ionic conductivity, and enabling the hydrogel to have stable electrical properties by virtue of an ionic conductivity mechanism. Benefited from the strong interface bonding effect between the aramid nanofiber and the polyacrylamide matrix, the hydrogel shows excellent mechanical properties, and has both flexibility and elasticity. In addition, due to the sensitive electric response characteristic and high stability, the material can serve as a substrate material of wearable equipment, the human body movement and rehabilitation state is monitored in real time, and the wide application prospect is achieved in the field of flexible electronics.

This invention relates to the field of pharmaceutical technology, specifically to a dynamic covalent hydrogel dressing loaded with moxa nanoparticles, its preparation method, and its application. The dynamic covalent hydrogel dressing loaded with moxa nanoparticles is composed of a dispersion of moxa nanoparticles made from moxa, aloe polysaccharides, and tea saponins, and a hydrogel matrix made from chitosan, polyvinyl alcohol, ε-polylysine, and 4-formylphenylboronic acid. This invention provides a multifunctional traditional Chinese medicine nanocomposite hydrogel dressing integrating intelligent response, antibacterial membrane-breaking, antioxidant, cell repair promotion, and wound healing promotion. It can provide a safe, efficient, and targeted novel solution for the clinical treatment of deep burns complicated with drug-resistant bacterial infections, and provides an experimental basis and technical reference for the formulation development and application of active ingredients of traditional Chinese medicine in wound repair.

A 3D-printed cervical plug. A 3D-printed cervical plug support is filled with a nanocomposite hydrogel. The nanocomposite hydrogel is a supramolecular nanocomposite formed by self-assembly of (-)-epigallocatechin-3-gallate and metal ions in a hydrogel.

The present application relates to a kind of drug-loaded nanocomposite hydrogel and its preparation method and application.A kind of drug-loaded nanocomposite hydrogel, the drug-loaded nanocomposite hydrogel is the drug-loaded hollow manganese dioxide nanoparticle modified by inulin hydrogel on surface;The drug is selected from: the drug with intestinal tract as target point;The hollow manganese dioxide nanoparticle is loaded at least one described drug.The drug-loaded nanocomposite hydrogel of the present application can realize colon site targeted drug delivery, increase the retention time and accumulation amount of drug in colon, also can regulate intestinal flora, stimulate the immune function of organism, and then improve the prevention and treatment effect of drug.Moreover, since the hollow manganese dioxide nanoparticle in the present application has super large hollow volume, can load double drug or multiple drugs, reaches the effect of comprehensive treatment of intestinal disease.

This invention relates to a composite hydrogel with hemostatic and antibacterial functions, its preparation method, and its application. The nanocomposite hydrogel is prepared by copolymerizing graphene oxide loaded with silver nanoparticles and chitosan grafted with dihydroporphyrin E6 during the preparation of thermosensitive poly(N-isopropylacrylamide) hydrogel. This composite hydrogel integrates multiple functions such as antibacterial, hemostatic, and cell proliferation and migration promotion. It possesses excellent thermosensitivity, injectability, swelling properties, tissue adhesion, and biodegradability. It achieves highly efficient antibacterial activity through photothermal-photodynamic synergy and multiple antibacterial components. Furthermore, it effectively controls bleeding by utilizing the sealing effect of the hydrogel and the hemostatic properties of chitosan, while simultaneously promoting fibroblast proliferation and migration. It plays a positive role in all stages of wound healing and is suitable for use as a dressing for infected skin wounds.

This invention discloses an oil-water separation membrane with a surface-modified nanocomposite hydrogel and its modification method, belonging to the field of oil-water separation. The method involves a simple filtration and alternating immersion process to modify the surface of various hydrophobic separation membranes with a nanostructured nanocomposite hydrogel layer. The nanocomposite hydrogel is composed of hydrogel and nanoparticles; the hydrogel is formed from polyvinylpyrrolidone and polyphenols, and the nanoparticles are formed by the complexation of iron ions and polyphenols. Compared to smooth hydrogels, the nanostructured hydrogel possesses superior wettability and underwater resistance to high-viscosity oil droplet adhesion, effectively protecting the base membrane and achieving efficient separation of high-viscosity emulsified oil. Compared to conventional methods for modifying separation membranes with nanohydrogels, this strategy has the advantages of simple operation and wider applicability.

The invention discloses light-response multifunctional nano-composite hydrogel as well as a preparation method and application thereof, belongs to the technical field of biomedical materials, and aims to solve the technical problems that an existing wound dressing is single in function and difficult to meet complex clinical requirements (such as stable wound covering, exudate management, efficient antibacterial and healing-promoting synergistic effects). The PGC-ZnO nano composite hydrogel is constructed by introducing zinc oxide nano particles into a polyacrylamide / gelatin / carboxymethyl chitosan composite network. The multi-level crosslinking effect (covalent main chain, coordination network and physical entanglement) of the composite network is utilized to improve the mechanical property and stability of the hydrogel, the synergistic effect of ZnO NPs and near-infrared light is utilized to realize efficient antibiosis, and meanwhile, the wound microenvironment is synergistically regulated and controlled through the components, so that the wound healing effect is improved. And finally, the hydrogel is endowed with excellent wound surface adaptability, exudate management capability, antibacterial activity and healing promotion performance, and a multifunctional dressing solution is provided for clinical complex wound surface treatment.

The application discloses a tumor microenvironment responsive nano-composite hydrogel co-drug delivery system and a preparation method thereof, and belongs to the field of antitumor materials. The nano-composite hydrogel co-drug delivery system is a sodium alginate hydrogel with hyaluronic acid encapsulated drug-loaded nanoparticles embedded in the interior. The drug-loaded nanoparticles encapsulate anthracycline chemotherapy drugs and tyrosine kinase inhibitors; the anthracycline chemotherapy drugs are connected to the hyaluronic acid side chain through a hydrazone bond to form a polymer prodrug, and the tyrosine kinase inhibitors are encapsulated into the hydrophobic core of the nanoparticles through self-assembly of the polymer prodrug molecules to obtain the hyaluronic acid encapsulated drug-loaded nanoparticles. The sodium alginate hydrogel is a dopamine modified sodium alginate hydrogel. The nano-composite hydrogel co-drug delivery system is easy to be injected intratumorally and paratumorally, can be slowly degraded in the body, and can target and synchronously deliver the drugs to tumor cells by using the escaped nanoparticles, so as to inhibit tumor cell proliferation, invasion and migration, and realize a synergistic antitumor effect.

The application discloses a calcium phosphate oligomer cross-linked biomimetic nanocomposite hydrogel and a preparation method and application thereof, and relates to the technical field of medical materials. The application provides a self-cross-linked double-network hydrogel (GOP), wherein a Schiff base reaction main network is constructed through a Schiff base reaction between sodium alginate (OSA) oxidized by a periodate and Gel, and small-size calcium phosphate oligomers (CPO) participate in intermolecular bonding to establish a secondary network. The double-network structure solves the problem of insufficient mechanical strength of a traditional hydrogel, and the elastic modulus of the double-network hydrogel is 2-5 times higher than that of a single OSA / Gel hydrogel, which is beneficial to bearing the cyclic mechanical load of a bone defect site.

The present application relates to the technical field of biomedical materials, and particularly relates to hierarchical loading and in-situ controlled release of nanocomposite hydrogel materials and preparation and application thereof. The nanocomposite hydrogel material comprises drug-loaded nanoparticles and drug-loaded hydrogel coated on the surface of the drug-loaded nanoparticles; the drug-loaded nanoparticles comprise nanoparticles and hydrophobic drugs; the nanoparticles are formed by self-assembly of quaternary ammonium salt-perfluoroalkane chain bifunctional polymer materials, have charge reversal and penetration promotion functions, and enhance drug delivery efficiency; the drug-loaded hydrogel comprises hydrogel and hydrophilic drugs; the hydrogel contains Schiff base bonds and thioketone bonds, can respond to low pH and high ROS signals in a tumor microenvironment, and trigger controlled release. Through response to the tumor microenvironment, long-term, precise release and local penetration of drugs are realized, an innovative strategy of long-term local drug delivery, step-by-step penetration and combined treatment is provided, and treatment effect is significantly improved and toxic side effects are reduced.

The present application relates to a kind of basalt fiber infiltrant based on nanocomposite microgel and its preparation method, belong to infiltrant technical field.The mass fraction of nanocomposite microgel is 0.5%~1.5% in the total mass of the infiltrant is 100%, the rest is the water of deionized water purity above;The particle size of the nanocomposite microgel is 10 nm~20 nm, obtained by crushing, swelling from nanocomposite hydrogel;The nanocomposite hydrogel is composed of acrylic polymer and inorganic nanoparticles.First, nanocomposite hydrogel is prepared by free radical in-situ polymerization, then nanocomposite microgel is prepared by crushing-swelling method.The infiltrant can significantly improve the bunching of basalt fiber, improve mechanical properties, and then improve the interface performance of basalt fiber composite.

This invention relates to biomedical materials, specifically to a method for preparing Ti3C2-MXene@GelMA nanocomposite hydrogel and its application. The preparation method involves: adding Ti3AlC2 MAX phase powder to a 40-50% HF solution, vigorously stirring and etching to remove the Al layer, centrifuging, washing, neutralizing, and intercalating to obtain a few-layer / monolayer Ti3C2-MXene nanosheet dispersion; mixing the dispersion into a GelMA solution, uniformly dispersing to obtain an MG prepolymer dispersion, irradiating under an LED light source to achieve photocuring and crosslinking, and then vacuum freeze-drying to obtain the Ti3C2-MXene@GelMA nanocomposite hydrogel. The hydrogel prepared by this method not only enhances mechanical properties but also effectively reverses the inhibitory effect of the high-glucose microenvironment on fibroblast migration, significantly enhancing the motility efficiency of fibroblasts under high-glucose injury, promoting granulation tissue formation and wound contraction, thereby promoting chronic wound healing.

The invention discloses a gelatin-based nano composite hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: introducing iron-polyphenol nanoparticles into a gelatin solution, cooling and gelatinizing to form the gelatin-based nano composite hydrogel. The preparation process only relates to simple physical mixing and cooling operation, the process conditions are mild, the repeatability is excellent, and the preparation complexity and production cost of the hydrogel are remarkably reduced. The gelatin-based nano composite hydrogel prepared by the invention has sensitive responsiveness to environment temperature change and near-infrared illumination, can realize reversible regulation and control of rigidity, shows excellent thermal response and light response performance, further realizes time-space accurate and on-demand delivery and release of entrapped drugs, and is suitable for the field of controllable drug release.

This invention discloses a method for preparing a nanocomposite hydrogel and its application in preventing postoperative tissue adhesions. The hydrogel consists of a basic framework of adipate dihydrazide-functionalized polysaccharide-drug-loaded nanomicelles cross-linked via dynamic acylhydrazone bonds. Further, benzodiazepine is formed through a click reaction between a dihydrolipoic acid prodrug molecule containing 2-formylphenylboronic acid and the functionalized polysaccharide, reinforcing the cross-linking density of the gel network and endowing it with reactive oxygen species-responsive sequential drug release functionality. This hydrogel possesses strong mechanical strength and can adhere to the wound surface, effectively isolating damaged peritoneum. In the highly reactive oxygen species environment of the postoperative wound, the benzodiazepine bonds break, releasing dihydrolipoic acid, achieving a dual cascade scavenging of reactive oxygen species, thereby alleviating inflammatory responses and oxidative stress. Subsequently, the pore size of the gel network increases, accelerating the release of antifibrotic drugs loaded in the micelles, thus effectively inhibiting the TGF-β1-mediated fibrosis process. Ultimately, this achieves effective prevention and treatment of postoperative adhesions.

The application provides a preparation method of a nanocomposite hydrogel, comprising the following steps: S1, preparing calcium phosphotungstate sub-nanowires; S2, dispersing PVA into a mixed solution of water and ethylene glycol to obtain a PVA dispersion; S3, adding the prepared calcium phosphotungstate sub-nanowires into the PVA dispersion to obtain a mixed solution with a certain viscosity; and S4, performing gelation treatment on the mixed solution with the certain viscosity to obtain calcium phosphotungstate sub-nanowire / PVA nanocomposite hydrogel. The preparation process is simple and easy to implement. Compared with a pure PVA hydrogel, the nanocomposite hydrogel prepared by the application has higher modulus and toughness, excellent mechanical properties, and wide applicability and promotion value.

The invention belongs to the technical field of biomedical engineering materials, and discloses a nano composite hydrogel for diabetic bone repair and a preparation method thereof.The preparation method comprises the steps that oxidized hyaluronic acid is prepared and modified through phenylboronic acid to obtain OHA-PBA; then preparing a halloysite nanotube loaded with bulbus lilii glycoside B; and finally, uniformly mixing an OHA-PBA aqueous solution with the RB-HNT powder, adding a polyvinyl alcohol aqueous solution, and constructing a dynamic cross-linked network through reversible borate bonds formed by phenylboronic acid and hydroxyl groups and hydrogen bonds formed by the hydroxyl groups on the surface of the RB-HNT and the polymer. The nano-composite hydrogel disclosed by the invention has diabetes pathology microenvironment responsiveness, can be controllably degraded under high glucose, ROS or acidic conditions, slowly releases RB and silicon ions, and synergistically exerts antioxidant, anti-inflammatory and osteogenesis promoting effects; meanwhile, excellent injectability and self-healing ability are achieved, the material can be attached to irregular bone defect parts, and minimally invasive drug delivery is achieved.

A nanocomposite hydrogel suitable for bone tissue regeneration can include (i) a scaffold including serum albumin cross-linked with polyethylene glycol and a cell adhesion promoter; (ii) and nanoparticles dispersed in the scaffold. The nanocomposite hydrogel may be formed from an injectable composition. The injectable composition comprises a nano composite hydrogel precursor A and a nano composite hydrogel precursor B. The nano composite hydrogel precursor A comprises polyethylene glycol (PEG-NHS) with N-hydroxysuccinimide end groups at two ends or multiple arms; the nano composite hydrogel precursor B is prepared from serum albumin, nano particles and a cell adhesion accelerant; wherein the nano-composite hydrogel precursor A and the nano-composite hydrogel precursor B are kept physically separated from each other.

The application discloses a gelatin-based nanocomposite hydrogel and a preparation method and application thereof. The preparation method introduces iron-polyphenol nanoparticles into a gelatin solution, and forms the gelatin-based nanocomposite hydrogel through cooling gelation. The preparation process only involves simple physical mixing and cooling operation, and has mild process conditions and excellent repeatability, thereby significantly reducing the preparation complexity and production cost of the hydrogel. The gelatin-based nanocomposite hydrogel prepared by the application has sensitive responsiveness to environmental temperature change and near-infrared light, can realize reversible regulation of rigidity, and has excellent thermal response and light response performance, thereby realizing time-space accurate and on-demand release of encapsulated drugs, and being suitable for the field of controllable drug release.

Embodiments relate to acellular nanocomposite hydrogels exhibiting extracellular matrix (ECM)-like mechanics and self-healing properties. In particular, embodiments relate to nanocomposite hydrogels including network-forming biopolymers and anisotropic hairy nanoparticle linkers configured to convert the biopolymers to ECM-like analogues via ionic and dynamic covalent bonds. Embodiments further relate to method of forming the nanocomposite hydrogels and to methods of regenerating tissue including integrating the nanocomposite hydrogels with host tissues.