54 results about "Nanocomposite hydrogels" patented technology

The invention discloses a near-infrared responsive injectable MXene / fibroin / carboxymethyl chitosan / oxidized hyaluronic acid nano composite hydrogel SCO (at) M, and relates to the technical field of biomedical materials. The method disclosed by the invention comprises the following steps: 1) preparing an MXene single-layer nanosheet by adopting LiF-HCl in-situ HF etching; (2) modifying the fibroin through glycidyl methacrylate to obtain SF-MA; 3) oxidizing hyaluronic acid with sodium periodate to obtain oxidized hyaluronic acid OHA; (4) uniformly dispersing MXene in the SF-MA solution, and sequentially adding carboxymethyl chitosan CMCS and OHA, so as to prepare the injectable nano composite soft hydrogel with the shear thinning characteristic; and 5) through ultraviolet irradiation crosslinking, rapid in-situ curing of the hydrogel is realized, and the mechanical strength of the hydrogel is improved. The hydrogel provided by the invention has excellent injectability and mechanical property, has good photo-thermal antibacterial property, oxidation resistance and cell compatibility, can be used as a carrier of cells, medicines and bioactive substances in the field of biological medicines, and has a wide application prospect.

The invention discloses organic nano composite hydrogel as well as a preparation method and application of the organic nano composite hydrogel, and belongs to the technical field of biological medicine delivery. The polysaccharide-based nano prodrug in the composite hydrogel can be subjected to surface protonation under the stimulation of a tumor extracellular slightly acidic environment, so that cellular uptake is promoted, low-pH / high-concentration glutathione in tumor cells is responded, intracellular aggregation and controllable release of the nano drug are realized, the retention time of the drug in the cells is prolonged, and the bioavailability of the drug is improved. The technical effect of killing tumor cells through combined chemotherapy is achieved. According to the preparation method disclosed by the invention, the release of the polysaccharide-based nano prodrug from the hydrogel and the tissue infiltration capacity are accelerated by adopting fluorinated orthoester, the infiltration of the polysaccharide-based nano prodrug to cells is increased, and then the drug-loaded compound is encapsulated by using gellan gum, so that the slow-release effect of the polysaccharide-based nano prodrug is enhanced; therefore, the efficient enrichment of the medicine at the tumor part is realized.

The invention relates to the technical field of composite hydrogel preparation, in particular to a nano composite hydrogel preparation process based on a microfluidic technology. The gel comprises the following components in parts by mass: 50-70 parts of a gel matrix, 5-9 parts of a nano enhancement system, 8-14 parts of a functional carrier, 3-6 parts of a dynamic response system, 4-7 parts of a hyaluronic acid-sulfhydrylated heparin compound and 0.5-1.5 parts of L-ascorbyl palmitate. Precise mixing and directional arrangement of all component materials on a micro-level are realized through a microfluidic technology, so that a nano reinforcing system and a functional carrier are uniformly distributed in a gel matrix, the synergistic effect of all the components is fully exerted, the mechanical property and the biological function of the gel are effectively improved, and the preparation method is suitable for industrial production. And quaternized chitosan nanofibers, a dynamic response system for responding to external environment change and a hyaluronic acid-sulfhydrylated heparin compound for promoting angiogenesis are introduced, so that the gel has the biological functions of resisting bacteria and promoting angiogenesis through a synergistic effect.

The invention belongs to the technical field of biological materials, and particularly relates to nano composite hydrogel as well as a preparation method and application thereof. In the preparation process of the hydrogel, preparation of gelatin hydrazide and preparation of pullulan oxidation are sequentially completed, then preparation of active component loaded PLGA nanoparticles and self-assembly coating with metal-polyphenol are completed, and finally, the metal-polyphenol coated PLGA nanoparticles are mixed with gelatin hydrazide and pullulan oxidation to form gel in situ. The hydrogel has the characteristics of injectability, self-healing, wet adhesion and the like, the metal-polyphenol layer has the effects of resisting inflammation, resisting oxidation and promoting angiogenesis and generates photo-thermal response to near infrared rays, on-demand controllable release of the drug-loaded nanoparticles is achieved, the composite hydrogel can improve the wound surface microenvironment, promote angiogenesis and inhibit inflammation and scar formation, and the drug-loaded nanoparticles can be applied to wound healing. The ointment is suitable for burns, scalds and various complex wounds.

The invention belongs to the technical field of biomedical materials, and discloses a preparation method of nano composite hydrogel and application of the nano composite hydrogel in acceleration of healing of diabetic wounds. The invention constructs the hydrogel based on the epsilon-polylysine grafted by the oxidized hyaluronic acid and the phenylboronic acid and the ZIF-8. Due to the existence of the dynamic Schiff base, the boric acid ester bond and the coordination bond, the hydrogel has ideal mechanical property, strong viscosity, injectability, self-healing property and pH / ROS responsiveness. Due to the existence of chlorogenic acid and zinc ions, the hydrogel regulates macrophage phenotypes, relieves oxidative stress and accelerates healing of diabetic wounds through an NF-kappa B / JAK-STAT signal channel.

The invention discloses nano composite hydrogel modified silica gel as well as a preparation method and application thereof. The method comprises the following steps: (1) preparing carbon nanoparticles; (2) preparing a polyvinyl alcohol aqueous solution and a pre-polymerized solution of carbon nanoparticles and hydrogel; (3) preparation of nano-composite hydrogel modified silica gel: adding the pre-polymerized liquid and silica gel into the polyvinyl alcohol aqueous solution under stirring, adding an initiator, carrying out hot bath, carrying out condensation reflux in an inert atmosphere for reaction, and then adding a polyvinyl alcohol cross-linking agent and an HCl aqueous solution for reaction; and after the reaction is finished, centrifugally washing and drying to obtain the nano-composite hydrogel modified silica gel. The nano-composite hydrogel modified silica gel has excellent hydrophilicity, can be used as a hydrophilic mode liquid chromatography filler, and has great development space and application potential in the field of chromatographic separation and analysis.

The invention relates to the technical field of biological materials, and discloses a preparation method of novel antibacterial nano composite hydrogel for repairing diabetic oral ulcer. Comprising the following steps: grafting 2-formylphenylboronic acid on titanium carbide (MXene) nanosheets to form MXene (at) FPBA nanoparticles, carrying out an amidation reaction on lipoic acid and recombinant collagen to obtain modified recombinant collagen, doping the MXene (at) FPBA into the modified recombinant collagen system, and carrying out photo-crosslinking to obtain the novel antibacterial nano composite hydrogel. The hydrogel combines the strong anti-oxidation and anti-inflammatory capabilities of lipoic acid, does not need to add anti-inflammatory drugs, and also has good adhesiveness; the MXene (at) FPBA nano particles can be used for capturing bacteria and carrying out efficient sterilization; and the raw materials used by the material have biological safety. Therefore, the hydrogel has the antibacterial property and the anti-inflammatory function, and can comprehensively and efficiently manage and treat diabetic oral ulcer wounds.

The invention provides a device for detecting pesticide in water based on nano-composite hydrogel and a preparation method. The device comprises first hydrogel and second hydrogel which are attached to each other, first ITO conductive glass is attached to the side, away from the second hydrogel, of the first hydrogel, second ITO conductive glass is attached to the side, away from the first hydrogel, of the second hydrogel, and the first ITO conductive glass and the second ITO conductive glass are covered with ITO films; the ITO film is connected with a voltage detection unit through a wire, and the voltage detection unit is connected with a display; the wall surface of the porous structure in the first hydrogel is positively charged and has anion selectivity; the wall surface of the porous structure in the second hydrogel is negatively charged and has cation selectivity. According to the invention, the information of the pesticide in water can be judged by detecting the voltage signal by utilizing an ion diffusion migration mechanism, and the method has the advantages of high detection speed, portability, easiness in operation and the like.

The invention provides biological nano composite hydrogel as well as a preparation method and application thereof, and the preparation method of the biological nano composite hydrogel comprises the following steps: dissolving VVPS and beta-CD in a NaOH aqueous solution, heating to 60-63 DEG C, and stirring for more than 30 minutes until the VVPS and the beta-CD are completely dissolved; slowly adding PEGDGE into the solution, continuously stirring until the cross-linking agent is dissolved, raising the temperature to 65 DEG C or above, and reacting for 4 hours or above to form hydrogel; and performing swelling treatment on the hydrogel, drying, soaking in an ethanol water solution containing capsaicin for more than 48 hours, filtering, and performing freeze drying. The biological nano composite hydrogel prepared by the preparation method disclosed by the invention has good application in delivery of capsaicin and alleviation of type II diabetes mellitus.

The invention provides a preparation method of acacia gum nano-composite hydrogel. The preparation method comprises the following steps: S1, mixing an acacia gum aqueous solution with a free radical initiator, and then sequentially adding acrylonitrile, CuFe2O4 nanoparticles and a cross-linking agent into the mixture to obtain the acacia gum nano composite hydrogel. The acacia gum nano-composite hydrogel combines the characteristics of a natural polymer, a synthetic polymer and inorganic nanoparticles, and is an effective adsorbent for removing heavy metals in an aqueous solution, the prepared magnetic hydrogel is treated by hydroxylamine hydrochloride, so that a nitrile group is converted into an amidoxime group to serve as a bidentate ligand, and the adsorption capacity of the hydrogel is improved. The existence of CuFe2O4 in the acacia gum nano-composite hydrogel makes the recoverable magnetic hydrogel possible, the recoverable magnetic hydrogel can be easily removed from an aqueous solution and regenerated, and after three continuous cycles, the recoverable magnetic hydrogel still has high heavy metal adsorption capacity.

The present invention provides a preparation method for a nano-drug composite dynamic cross-linked hydrogel with curcumin / nitric oxide / photothermal synergistic antibacterial effect. The present invention uses copper salt to chelate curcumin to form first nanoparticles, and then uses polydopamine to coat the first nanoparticles to form nano-drug P Cur Sodium nitroprusside and sodium phytate were used as raw materials and nano-coprecipitation method was used to prepare second nanoparticles; polydopamine was then used to coat the second nanoparticles to prepare a core-shell structure nano drug P NO ; The nano drug P cur and P NO The nanocomposite hydrogel is mixed evenly with carboxymethyl chitosan and oxidized hyaluronic acid to form a nanocomposite dynamically cross-linked hydrogel. In addition to its significant antibacterial properties, the nanocomposite hydrogel of the present invention also has significant advantages such as high antibacterial efficacy, good biosafety, convenient preparation, and low cost. The present invention also combines drug, photothermal, and gas therapy in a single device, facilitating synergistic and precise bacterial elimination.

The application discloses a kind of low modulus high ductility super-retarding concrete, the concrete includes by weight ratio: cement 254~360 parts, fly ash 68~108 parts, slag powder 68~70 parts, 5~16mm gravel 352~393 parts, 16~25mm gravel 660~729 parts, medium sand 669~705 parts, rubber powder 20 parts, polystyrene plastic 15 parts, water 150 parts, water reducing agent 5.9~7.5 parts, super-retarding agent 3.1~4.0 parts, water-based polyurethane 15 parts, nano composite hydrogel 15 parts, polyolefin elastomer 5 parts, polypropylene fiber 1.0 part, can have higher toughness, lower elastic modulus, and can reach design requirement strength and durability, simultaneously, when practical application, first, a layer of low modulus high ductility super-retarding concrete is poured, then continue to pour ordinary concrete, combined with other anti-cracking measures, can effectively reduce the constraint degree of bottom plate to upper portion, prevent temperature cracks.

The application relates to a sizing agent for rayon and a preparation method thereof, which comprises the following components in mass fractions: 900-1100 parts of methyl acrylate, 100-140 parts of acrylic acid, 110-150 parts of methyl methacrylate, 340-380 parts of acrylonitrile, 330-340 parts of ethanol, 2.5-3 parts of mercaptan, 130-150 parts of sodium dodecyl benzene sulfonate, 1.5-2.5 parts of whiting, 280-300 parts of smoothing agent, 18-20 parts of antistatic agent, 13-17 parts of bactericide, and the balance of water; and further comprising a nano composite hydrogel, wherein the nano composite hydrogel comprises L-arginine, silicotungstic acid, acrylic acid and a modified montmorillonite system. The application has the effects of improving the flexibility and wear resistance of the sizing agent for rayon.

The application discloses a temperature-sensitive nanocomposite hydrogel for extinguishing and preventing re-ignition of lithium iron phosphate batteries and a preparation method thereof, and relates to the technical field of battery extinguishing and re-ignition prevention. First, a phase change heat storage microcapsule material is prepared by taking a dodecahydrate sodium hydrogen phosphate solution, an alkali compound and an ethanol solution of tetraethyl orthosilicate as raw materials; then, polyphosphoric acid-amino acid polymer is prepared by adding arginine into an ethanol solution of polyphosphoric acid; finally, the temperature-sensitive nanocomposite hydrogel is prepared by adding the phase change heat storage microcapsule material and the polyphosphoric acid-amino acid polymer into a hydrophilic gel material. The temperature-sensitive nanocomposite hydrogel has the comprehensive advantages of efficient extinguishing, rapid cooling and persistent re-ignition prevention, and the temperature-sensitive nanocomposite hydrogel reduces economic losses caused by lithium ion battery fires by combining physical cooling, chemical inhibition and physical isolation.

This invention discloses a temperature- and pressure-sensitive, high-strength, and tough multifunctional nanocomposite hydrogel and its preparation method, belonging to the field of hydrogel technology. The invention first isolates tunicin from sea squirts and hydrolyzes it with acid to obtain sea squirt nanocellulose. Hydroxypropyl cellulose is dissolved in deionized water, sodium dodecyl sulfate is added, and the mixture is sonicated until dissolved. Then, octadecyl methacrylate, acrylamide, sea squirt nanocellulose suspension, and MXene / Ag nanosheet dispersion are added sequentially, and the mixture is mixed with an initiator. Emulsion polymerization is then performed to obtain the nanocomposite hydrogel product. The reaction disclosed in this invention is easy to operate and operates under mild conditions. Furthermore, the nanocomposite hydrogel prepared by the method disclosed in this invention exhibits high efficiency in multiple sensitivities (temperature and pressure), high strength, and excellent biocompatibility, showing broad application prospects in disease diagnosis and daily monitoring in the medical and pharmaceutical fields.

An elastomeric nanocomposite hydrogel includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles. The elastomeric nanocomposite hydrogel is cytocompatible, and, upon degradation, produce substantially non-toxic products.

The invention discloses a sunscreen moisturizing nano composite hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: adding a flower-like titanium dioxide nano material and a vinyl-containing hydrophilic monomer into water, and carrying out ultrasonic dissolution under the protection of nitrogen to obtain a precursor solution of the hydrogel; and irradiating the precursor solution of the hydrogel under a high-pressure ultraviolet lamp to obtain the sunscreen and moisturizing nano composite hydrogel. The sunscreen and moisturizing nano-composite hydrogel is simple in formula component and convenient in preparation process, sunscreen and moisturizing functions can be realized without adding extra humectants and sunscreen agents, and the sunscreen and moisturizing nano-composite hydrogel has good economical efficiency and universality and provides a new idea for preparation of the sunscreen and moisturizing hydrogel.

The invention discloses a nano composite hydrogel based on phase engineering 1T-MoSe2 as well as a preparation method and application of the nano composite hydrogel. The nano composite hydrogel comprises a temperature-sensitive hydrogel matrix, and the < 1 > T-MoSe2 nanosheets are dispersed in the hydrogel matrix. The hydrogel loaded with the 1T-MoSe2 nanosheets is used for preparing the medicine or dressing for treating the diabetic chronic wounds, the dressing can generate a large amount of ROS and generate the photothermal effect under the combined stimulation of exogenous ultrasound (US) and near-infrared light (NIR), and the hydrogel has efficient photothermal response and ROS generation capacity and can be used for preparing the medicine or dressing for treating the diabetic chronic wounds. Low-concentration hydrogen peroxide can be catalyzed to generate a large amount of hydroxyl radicals (. OH), and the broad-spectrum sterilization effect on various bacteria is achieved in combination with the photothermal effect; when no exogenous stimulation exists, inherent SOD and CAT-like enzyme activity is shown, excessive active oxygen is removed, the oxidative stress state of the wound surface is effectively relieved, polarization of macrophages to M2 anti-inflammatory phenotypes is promoted, and control over the inflammatory state is achieved.

The preparation method comprises the following steps: carrying out surface modification and uniform dispersion treatment on aramid fibers to prepare an aramid nanofiber dispersion liquid; adding the aramid nanofiber dispersion liquid into the polyacrylamide prepolymerization solution, and uniformly stirring to obtain a mixed solution; and carrying out in-situ polymerization treatment on the mixed solution to obtain the nano-composite hydrogel, adding metal salt to endow the hydrogel with ionic conductivity, and enabling the hydrogel to have stable electrical properties by virtue of an ionic conductivity mechanism. Benefited from the strong interface bonding effect between the aramid nanofiber and the polyacrylamide matrix, the hydrogel shows excellent mechanical properties, and has both flexibility and elasticity. In addition, due to the sensitive electric response characteristic and high stability, the material can serve as a substrate material of wearable equipment, the human body movement and rehabilitation state is monitored in real time, and the wide application prospect is achieved in the field of flexible electronics.

This invention relates to the field of pharmaceutical technology, specifically to a dynamic covalent hydrogel dressing loaded with moxa nanoparticles, its preparation method, and its application. The dynamic covalent hydrogel dressing loaded with moxa nanoparticles is composed of a dispersion of moxa nanoparticles made from moxa, aloe polysaccharides, and tea saponins, and a hydrogel matrix made from chitosan, polyvinyl alcohol, ε-polylysine, and 4-formylphenylboronic acid. This invention provides a multifunctional traditional Chinese medicine nanocomposite hydrogel dressing integrating intelligent response, antibacterial membrane-breaking, antioxidant, cell repair promotion, and wound healing promotion. It can provide a safe, efficient, and targeted novel solution for the clinical treatment of deep burns complicated with drug-resistant bacterial infections, and provides an experimental basis and technical reference for the formulation development and application of active ingredients of traditional Chinese medicine in wound repair.

The invention relates to the technical field of biomedical materials, in particular to a graded-loading and in-situ controlled-release nano-composite hydrogel material as well as preparation and application thereof. The nano composite hydrogel material comprises drug-loaded nano particles and drug-loaded hydrogel coated on the surfaces of the drug-loaded nano particles, the drug-loaded nanoparticles comprise nanoparticles and a hydrophobic drug; the nanoparticles are formed by self-assembly of a quaternary ammonium salt-perfluoroalkane chain bifunctional high polymer material, have charge overturning and permeation promoting functions, and enhance the drug delivery efficiency; the drug-loaded hydrogel comprises hydrogel and a hydrophilic drug; the hydrogel contains a Schiff base bond and a thioketal bond, and can respond to low pH and high ROS signals in a tumor microenvironment to trigger controlled release. Through response to a tumor microenvironment, long-acting and accurate release and local permeation of the medicine are realized, an innovative strategy of long-time local administration, step-by-step permeation and combined treatment is provided, the treatment effect is remarkably improved, and toxic and side effects are reduced.

A 3D-printed cervical plug. A 3D-printed cervical plug support is filled with a nanocomposite hydrogel. The nanocomposite hydrogel is a supramolecular nanocomposite formed by self-assembly of (-)-epigallocatechin-3-gallate and metal ions in a hydrogel.

The present invention discloses a double-nano composite gel coating stab-proof composite fabric and a preparation method thereof. The preparation method comprises the following steps: dissolving polyether F127 diacrylate in a solvent, magnetically stirring for 24 hours, then adding nano titanium nitride (TiN) under stirring conditions, dissolving and ultrasonicating for 4 hours, then bubbling with nitrogen for 15 minutes, adding monomers, catalysts, and initiators to the solution, polymerizing at room temperature for 24 hours to obtain a double-nano composite hydrogel, and fully coating the double-nano composite hydrogel on a stab-proof fabric having a certain stab-proof function. The double-nano composite hydrogel is then allowed to stand in a sealed environment for polymerization for 24 hours to obtain a double-nano composite gel coating stab-proof composite fabric. When the coated stab-proof fabric formed by combining the double-nano composite hydrogel with the fiber fabric is damaged, the damage to the fiber cannot be restored. However, due to the excellent light-to-heat conversion performance of the nano titanium nitride, the hydrogel at the fabric coating effectively repairs the damaged parts of the double-nano composite gel coating stab-proof composite fabric. Therefore, the double-nano composite gel coating stab-proof composite fabric still has a certain stab-proof effect after self-healing.

Nanocomposite hydrogels suitable for bone tissue regeneration may include (i) a scaffold comprising serum albumin and a cell adhesion promoter crosslinked with polyethylene glycol and (ii) a nanoparticle dispersed in the scaffold. Said nanocomposite hydrogels may formed from an injectable composition that includes: a nanocomposite hydrogel precursor A comprising that comprises a polyethylene glycol with two or more N-hydroxysuccinimide-terminal groups (PEG-NHS); and a nanocomposite hydrogel precursor B comprising a serum albumin, a nanoparticle, and a cell adhesion promoter; wherein the nanocomposite hydrogel precursor A and the nanocomposite hydrogel precursor B are physically separated.

The present invention discloses a preparation method and application of an immune nanocomposite hydrogel with anti-tumor effect, wherein dopamine-modified hyaluronic acid is added to water to form a dopamine-modified hyaluronic acid aqueous solution, δ-ALA@PLGA microspheres are then added, dopamine is added, sodium periodate is added, dopamine polymerization is induced under stirring, and then the mixture is allowed to stand to form a polydopamine hydrogel; sodium alginate and aCD47@CaCO3 nanoparticles are added to water to obtain a sodium alginate solution; the sodium alginate solution is added to the polydopamine hydrogel, calcium chloride solution is added, and the mixture is allowed to stand. The present invention can achieve the production of hydrogel by simple mixing, has a short reaction cycle, a high yield, no by-products, is easy to realize industrial production, and can effectively improve work efficiency. The composite hydrogel can be used as a new bioactive material for tumor treatment and can be used as a gel patch that adheres to the lesion and releases drugs for a long time.

The present application relates to a kind of drug-loaded nanocomposite hydrogel and its preparation method and application.A kind of drug-loaded nanocomposite hydrogel, the drug-loaded nanocomposite hydrogel is the drug-loaded hollow manganese dioxide nanoparticle modified by inulin hydrogel on surface;The drug is selected from: the drug with intestinal tract as target point;The hollow manganese dioxide nanoparticle is loaded at least one described drug.The drug-loaded nanocomposite hydrogel of the present application can realize colon site targeted drug delivery, increase the retention time and accumulation amount of drug in colon, also can regulate intestinal flora, stimulate the immune function of organism, and then improve the prevention and treatment effect of drug.Moreover, since the hollow manganese dioxide nanoparticle in the present application has super large hollow volume, can load double drug or multiple drugs, reaches the effect of comprehensive treatment of intestinal disease.

The invention discloses anti-swelling multiple non-covalent bond polyvinyl alcohol / polyacrylic acid carbon nanotube nano-composite hydrogel, which overcomes the technical bottleneck that high swelling ratio, high toughness and high restorability of hydrogel are difficult to be compatible by regulating and controlling the dynamic balance of multiple non-covalent interaction in the nano-composite hydrogel. And the problems of insufficient comprehensive mechanical properties, sensing response lag and the like are solved. The multi-non-covalent bond polyvinyl alcohol / polyacrylic acid carbon nanotube nano composite hydrogel shows excellent comprehensive mechanical properties (high toughness and high recovery), swelling resistance and high-sensitivity underwater strain sensing performance, and is combined with a gait recognition algorithm based on machine learning, so that the underwater strain sensing performance of the hydrogel is improved. The hydrogel monitoring system provides a more convenient alternative scheme for intelligent rehabilitation monitoring and human gait recognition, and can be widely applied to the fields of exercise rehabilitation medical treatment, virtual reality rehabilitation, remote rehabilitation and the like.

The invention relates to the technical field of wound dressings, in particular to a rare-earth-based nano-composite hydrogel wound dressing and a preparation method and application thereof.The preparation method comprises the following steps that gel powder is added into a dispersing agent to be pre-dispersed, and gel dispersion liquid is obtained; adding a compound containing rare earth elements and / or rare earth nanoparticles into a dispersing agent for pre-dispersion to obtain a rare earth dispersion liquid; adding the gel dispersion liquid into the rare earth dispersion liquid at the temperature of 30-40 DEG C, adding part of deionized water, stirring for preliminary swelling, and then adding the rest deionized water in a stirring state until a gel dressing is formed; and adding a stabilizer into the gelatinous dressing, and stirring for reaction to obtain the rare-earth-based nano composite hydrogel wound dressing. According to the rare-earth-based nano-composite hydrogel wound dressing and the preparation method and application thereof, the mixing uniformity and stability of all the components in the dressing are improved, and therefore the performance of the dressing in the aspect of promoting wound healing is improved.

This invention relates to a composite hydrogel with hemostatic and antibacterial functions, its preparation method, and its application. The nanocomposite hydrogel is prepared by copolymerizing graphene oxide loaded with silver nanoparticles and chitosan grafted with dihydroporphyrin E6 during the preparation of thermosensitive poly(N-isopropylacrylamide) hydrogel. This composite hydrogel integrates multiple functions such as antibacterial, hemostatic, and cell proliferation and migration promotion. It possesses excellent thermosensitivity, injectability, swelling properties, tissue adhesion, and biodegradability. It achieves highly efficient antibacterial activity through photothermal-photodynamic synergy and multiple antibacterial components. Furthermore, it effectively controls bleeding by utilizing the sealing effect of the hydrogel and the hemostatic properties of chitosan, while simultaneously promoting fibroblast proliferation and migration. It plays a positive role in all stages of wound healing and is suitable for use as a dressing for infected skin wounds.

The application discloses a kind of nano composite hydrogel dressings with reversible adhesion-photothermal sterilization function and preparation method thereof.The preparation method includes the following:1) preparation of metal organic framework ZIF-8, which is immersed in a solution containing cyanidin CY-7 to achieve drug adsorption;DA is then used to coat the surface of the obtained sample to obtain ZIF-8 / CY-7 / PDA particles;2) preparation of 7-carboxymethoxyl-4-methyl coumarin CM with carboxyl at the end;3) through EDC coupling reaction, CM is grafted onto the side chain of dopamine-modified chitosan molecules to obtain CS-DA-CM;4) disperse ZIF-8 / CY-7 / PDA particles and angiogenic components in CS-DA-CM solution to obtain the dressing.The dressing can be injected and used, and can be gelled in situ to achieve adhesion when irradiated with a light source with a wavelength greater than 300 nm, and can be converted back to a solution when irradiated with a light source with a wavelength less than 280 nm;when an infrared wavelength with a wavelength of 820 nm is used, photothermal effect can be excited to achieve photothermal sterilization at the wound site, and photothermal effect can promote blood flow to accelerate wound healing.