424results about "Drug photocleavage" patented technology

The present invention relates to altering the physical and / or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and / or prevention of myopia. An activating energy source is utilized to photopolymerize or crosslink molecules in the sclera, thereby increasing the strength of the tissue. The individual is administered a crosslinking reagent or photopolymerizable molecule that becomes associated with the membrane, which is then precisely exposed to an energy source, such as light or ultrasound.

The invention is directed to methods and compositions for monitoring remodeling of an artificial tissue construct using image or contrast enhancing agents. The invention allows the growth, development, and remodeling of the artificial tissue to be monitored.

The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.

The present invention is for particulate compositions and methods for producing them that can absorb or scatter electromagnetic radiation. The particles are homogeneous in size and are comprised of a nonconducting inner layer that is surrounded by an electrically conducting material. The ratio of the thickness of the nonconducting layer to the thickness of the outer conducting shell is determinative of the wavelength of maximum absorbance or scattering of the particle. Unique solution phase methods for synthesizing the particles involve linking clusters of the conducting atoms, ions, or molecules to the nonconducting inner layer by linear molecules. This step can be followed by growth of the metal onto the clusters to form a coherent conducting shell that encapsulates the core.

The present invention provides nanoshell particles (“nanoshells”) for use in biosensing applications, along with their manner of making and methods of using the nanoshells for in vitro and in vivo detection of chemical and biological analytes, preferably by surface enhanced Raman light scattering. The preferred particles have a non-conducting core and a metal shell surrounding the core. For given core and shell materials, the ratio of the thickness (i.e., radius) of the core to the thickness of the metal shell is determinative of the wavelength of maximum absorbance of the particle. By controlling the relative core and shell thicknesses, biosensing metal nanoshells are fabricated which absorb light at any desired wavelength across the ultraviolet to infrared range of the electromagnetic spectrum. The surface of the particles are capable of inducing an enhanced SERS signal that is characteristic of an analyte of interest. In certain embodiments a biomolecule is conjugated to the metal shell and the SERS signal of a conformational change or a reaction product is detected.

A method for treating a cell proliferation disorder in a subject, comprising:(1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated; and(2) applying an initiation energy from an initiation energy source to the subject,wherein the initiation energy is capable of penetrating completely through the subject, and wherein the applied initiation energy activates the activatable agent by the simultaneous two photon absorption event in situ,thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation related disorder,and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.

The invention relates generally to transdermal and transmembrane delivery of biologically active substances through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transdermal and transmembrane delivery of biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods.

Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

The present invention generally relates to stimuli-responsive drug carriers and methods for making. More specifically, the present invention relates to stimuli-responsive lidded particles that respond to a physiological stimulus and dissolve at a target site inside the body thereby releasing therapeutic agents. The present invention further relates to solid, drug-loaded particles that are made from biodegradable polymers. The present invention further relates to methods for fabricating lidded particles and particles for drug delivery.

A fluorophore or conjugated polymer with aggregation-induced emission characteristics useful for drug tracking and delivery, identification and labeling of biological subjects, such as cells or parts of a cell, as well as for imaging, and image-guided photodynamic therapy are described herein.

Embodiments of the present invention relate to methods and pharmacological compositions to treat presbyopia in the human eye. According to the embodiments, pharmacological compositions may be applied to an eye to effect a change in the accommodative ability of the eye by the breaking and reduction of lenticular bonds in the eye that may be responsible for presbyopia. The compositions may be applied in an inactive state and subsequently be activated to achieve a therapeutic effect.

[Problems] A composition curable with active energy beams for use in skin patches is provided, which is liquid at ordinary temperature, has a practical crosslinking property or curability in the absence of photopolymerization initiators even when irradiated with visible or ultraviolet light, and provides cured films that are not discolored and excellent in various pressure-sensitive adhesive performances and have appropriate pressure-sensitive adhesiveness so as not to cause pain or damage to the horny layer in the patch-applied area even when patches are repeatedly applied and peeled off, as well as excellent water resistance. [Means for solving problems] The composition curable with active energy beams for use in skin patches is liquid at ordinary temperature and comprises (A) a compound having two or more maleimide groups and (B) an oil component, or water or a water-soluble compound.

An implantable medical device is provided including a vascular access device and a coating on at least one of an inner surface and an outer surface of the vascular access device. The coating includes: (a) a polymeric component including at least one of a light reactive moiety and a sound reactive moiety; and (b) at least one therapeutic agent releasably associated with the polymeric component, wherein a rate of release of the therapeutic agent is controlled by in situ exposure of the medical device to at least one of a light energy source and an ultrasound energy source.

The invention relates to a polydopamine-coated nanometer composite photothermal reagent and a preparation method thereof and belongs to the technical field of function materials. The method is simple to operate and two coating methods are provided: firstly, inorganic nanometer particles or the surface of an assembly of the inorganic nanometer particles are directly coated with a polydopamine shell layer through the oxidative polymerization character of a dopamine monomer; and secondly, nanometer particles are synthesized and coated by one step by utilizing the reducibility and the oxidative polymerization character of dopamine, so that the trouble of synthesizing the nanometer particles in advance is prevented, operation is more simple, and a synthesis method has better green environmental protection character. Proved by experiments, after the nanometer particles are coated with the polydopamine shell layer, the biocompatibility, the physiological environment stability and the photothermal stability of the nanometer particles are greatly improved; by introducing a hydroxyl functional group and an amino functional group, the condition of further modifying a biological targeting matter or a loaded medicine is supplied for the nanometer particles; and in addition, as the polydopamine has the photothermal character, the photothermal conversion efficiency of a material coated with the polydopamine shell layer is improved.

The present disclosure provides biophotonic topical compositions and methods useful in phototherapy. In particular, the biophotonic topical compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition. The biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

This invention provides a composition matter comprising rare earth-doped up-conversion nanoparticles (UCNPs) encapsulated with a silica shell. In one embodiment, a photosensitizer is incorporated into the silica shell. In another embodiment, the composition further comprises a targeting molecule. In still another embodiment, a small interfering RNA (siRNA) molecule is also attached to the silica shell with the targeting molecule. The invention further provides methods for synthesizing such compositions and for using them in therapeutic and diagnostic applications. These applications use infrared or near infrared activation to excite the UCNPs.

The invention relates to preparation and application of medicine-carrying polydopamine / dendrimer-gold nanoparticles. The preparation comprises the steps of modifying dendrimer-gold nanoparticles to the surfaces of polydopamine nanoparticles, and performing polyethylene glycol modification and anticancer medicine adriamycin loading. Obtained composite nanoparticles having a core-satellite structurecan be subjected to acid response to release minisize satellites, medicine delivery in deep tumors is realized, and medicine tolerance generated by tumor hypoxia is relieved; and adriamycin is released at a fixedpoint under internal (acid and hydrogen peroxide) and external (near infrared light) stimulation. The obtained composite nanoparticles have favorable biocompatibility, can realize optoacoustic diagnosis and photothermal treatment on tumor locations, and what's more, can realize remarkable restraining effects on tumor growth. Through the adoption of the method disclosed by the invention, the treatment effects of traditional chemical medicines can be notably improved, more comprehensive three-dimensional tumor treatment is realized, and a new thinking is provided for diagnosis and treatment of malignant tumors.

This invention effects a change in the accommodation of the human lens affected by presbyopia through the use of various reducing agents that change accommodative abilities of the human lens, and / or by applying energy to affect a change in the accommodative abilities of the human lens. This invention both prevents the onset of presbyopia as well as treats it. By breaking and / or preventing the formation of bonds that adhere lens fibers together causing hardening of the lens, the present invention increases the elasticity and distensibility of the lens and / or lens capsule.

Here, we present a photodegradable microparticle system that can be employed to entrap and deliver bioactive proteins to cells during culture. By using a photosensitive delivery system, experimenters can achieve a wide variety of spatiotemporally regulated release profiles with a single microparticle formulation, thereby enabling one to probe many questions as to how protein presentation can be manipulated to regulate cell function. Photodegradable microparticles were synthesized via inverse suspension polymerization with a mean diameter of 22 μm, and degradation was demonstrated upon exposure to several irradiation conditions. The protein-loaded depots were incorporated into cell cultures and release of bioactive protein was quantified during the photodegradation process. This phototriggered release allowed for the delivery of TGF-β1 to stimulate PE25 cells and for the delivery of fluorescently labeled Annexin V to assay apoptotic 3T3 fibroblasts during culture. By incorporating these photoresponsive protein delivery depots into cell culture, new types of experiments are now possible to test hypotheses about how individual or multiple soluble factors might affect cell function when presented in a uniform, temporally varying, or gradient manner.

This invention provides a composition matter comprising rare earth-doped up-conversion nanoparticles (UCNPs) encapsulated with a silica shell. In one embodiment, a photosensitizer is incorporated into the silica shell. In another embodiment, the composition further comprises a targeting molecule. In still another embodiment, a small interfering RNA (siRNA) molecule is also attached to the silica shell with the targeting molecule. The invention further provides methods for synthesizing such compositions and for using them in therapeutic and diagnostic applications. These applications use infrared or near infrared activation to excite the UCNPs.

The invention is directed to a therapy device, including a body, an energy source disposed on the body for emitting a desired wavelength of electromagnetic radiation, and a material dispensing system disposed on the body for dispensing a desired material for use with the device. Also disclosed are accessories and compositions used with the therapy device, including interchangeable energy source-containing heads and interchangeable material containers. Methods for using the therapy device are also disclosed.

The invention belongs to the field of biomedical materials, particularly relates to a preparing method of a core-shell structure drug carrier with near-infrared light exciting supermolecule valve light control drug release, and aims to solve the problems that a diagnosis and treatment agent cannot be controllably released in the aspects of time, space and dosage. The method includes the steps that upconversion nano particle cores are synthesized; upconversion nano particles with shells coated are synthesized; the outer layers of the upconversion nano particles are coated with mesoporous silica; the outer surfaces of the core-shell structure nano particles are modified with amino groups; surfactant is removed to form mesoporous; the outer surfaces of the core-shell structure nano particles are modified with guest molecules; doxorubicin hydrochloride is loaded, and pore passages are blocked. The core-shell structure drug carrier is used in cancer treatment, and timing and quantitative controlled release of anti-cancer drugs in tumor tissue is achieved.

The invention belongs to the technical field of cellulose hydrogel and particularly relates to a cellulose / N-isopropylacrylamide medicine controllable release hydrogel and a preparation method thereof. Dopamine is added to a cellulose solution, the surface of cellulose is modified, and the cellulose can wrap a cellulose macromolecule framework, so that the cellulose has the mechanical force reinforcement function and also has the photoresponse characteristic. Meanwhile, N-isopropylacrylamide is dispersed in the modified cellulose solution, through free radical solution polymerization, the hydrogel is formed, and accordingly the cellulose hydrogel is endowed with the near-infrared response characteristic and thermosensitivity. The nano composite hydrogel has certain potential application value in the fields of intelligent medicine control release materials and biomedical application.

A titanium dioxide composite having a molecular recognition capacity is obtained by modifying the surface of a fine titanium dioxide particle with a hydrophilic polymer in such a manner that titanium dioxide is bonded via an ester bond to a carboxyl group of the hydrophilic polymer and immobilizing a molecule having an ability to specifically bind to a target molecule to the carboxyl residue of the hydrophilic polymer. Due to the molecule distinguishability, this titanium dioxide complex can bind specifically to an endocrine disrupting chemical, a pathogenic factor, a cancer cell and the like and decompose the same by a photocatalytic function.

The invention relates to polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing having light-responsive bacteria resistance and a preparation method of the polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing, wherein a macromolecular medicine realizing fracturing under ultraviolet light is distributed inside the hydrogel dressing. The preparation method of the polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing comprises the following steps: grafting micromolecule antibiotic, namely, levofloxacin to polyethylene glycol macromolecular chains with amino groups at two ends through molecules with ultraviolet light response property, thus obtaining the macromolecular medicine realizing fracturing under ultraviolet light; and carrying out repeated freezing and thawing on a mixed solution of polyvinyl alcohol solution, sodium alginate solution and the macromolecular medicine realizing fracturing under ultraviolet light, thus obtaining the polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing having light-responsive bacteria resistance. The adopted raw materials have good biocompatibility, the obtained hydrogel dressing has certain mechanical property and has the ultraviolet-light-responsive antibacterial property, namely, the hydrogel dressing can realize controlled release of antibiotics under irradiation of 365nm ultraviolet light, and thus the polyvinyl alcohol / sodium alginate medicine-loading hydrogel dressing is suitable for protecting and treating the wound surface.

The invention relates generally to transdermal and transmembrane delivery of biologically active substances through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transdermal and transmembrane delivery of biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods.

A nanobioprocessor for protein and cell therapy comprises a selectively coated quantum dot having selected band gap energies, characteristic absorption, emission spectra and outer coatings for therapy and diagnostic purposes in biophotonics and nanomedicine, and an electromagnetic radiation and detector source configured to remotely heat and / or selectively excite the quantum dot to associate with target specific misfolded or anomalous proteins, diseased cells and tissue.

A fluorophore or conjugated polymer with aggregation-induced emission characteristics useful for drug tracking and delivery, identification and labeling of biological subjects, such as cells or parts of a cell, as well as for imaging, and image-guided photodynamic therapy are described herein.