Biophotonic compositions and methods for providing biophotonic treatment

a biophotonic and composition technology, applied in the field of biophotonic compositions and methods for providing biophotonic treatment, can solve the problems of undesired side effects, low therapeutic efficacy of existing regimens, etc., and achieve the effect of reducing the duration of systemic treatment tim

Inactive Publication Date: 2013-10-24
KLOX TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0036]The disclosed methods for treating acne or wounds may further include, for example, administering a systemic or topical drug before, during or after the biophotonic treatment. The drug may be an antibiotic, a hormone...

Problems solved by technology

Such regimens, however, are often associated with undesired side-effects, including systemic or localized toxicity due to the direct contact of the photosensitive agents wit...

Method used

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  • Biophotonic compositions and methods for providing biophotonic treatment
  • Biophotonic compositions and methods for providing biophotonic treatment
  • Biophotonic compositions and methods for providing biophotonic treatment

Examples

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example 1

[0237]The photodynamic properties of (i) Fluorescein sodium salt at about 0.09 mg / mL, (ii) Eosin Y at about 0.305 mg / mL, and (iii) a mixture of Fluorescein sodium salt at about 0.09 mg / mL and Eosin Y at about 0.305 mg / mL in a gel according to an embodiment of the present disclosure (comprising about 12% carbamide peroxide), were evaluated. A flexstation 384 II spectrometer was used with the following parameters: mode fluorescence, excitation 460 nm, emission spectra 465-750 nm. The absorption and emission spectra are shown in FIGS. 6a and 6b which indicate an energy transfer between the chromophores in the combination.

example 2

[0238]The photodynamic properties of (i) Fluorescein sodium salt at 0.18 mg / mL final concentration, (ii) Eosin Y at about 0.305 mg / mL, and (iii) a mixture of Fluorescein sodium salt at about 0.18 mg / mL and Eosin Y at about 0.305 mg / mL in an aqueous solution were evaluated. A flexstation 384 II spectrometer was used with the following parameters: mode fluorescence, excitation 460 nm, emission spectra 465-750 nm. The absorption and emission spectra are shown in FIGS. 7a and 7b which indicate an energy transfer between the chromophores in the combination.

example 3

[0239]The photodynamic properties of (i) Rose Bengal at about 0.085 mg / mL, (ii)

[0240]Fluorescein sodium salt at about 0.44 mg / mL final concentration, (ii) Eosin Y at about 0.305 mg / mL, and (iii) a mixture of (i), (ii) and (iii) in a gel comprising about 12% carbamide peroxide (Set A), according to an embodiment of the invention, were evaluated. A flexstation 384 II spectrometer was used with the following parameters: mode fluorescence, excitation 460 nm, emission spectra 465-750 nm. The absorbance and emission spectra are shown in FIGS. 8a and 8b which indicate an energy transfer between the chromophores in the chromophore combination.

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Abstract

The present disclosure provides biophotonic topical compositions and methods useful in phototherapy. In particular, the biophotonic topical compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition. The biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Application Nos. 61 / 636,480, filed Apr. 20, 2012; 61 / 701,502, filed Sep. 14, 2012; 61 / 636,574 filed on Apr. 20, 2012; 61 / 701,510, filed on Sep. 14, 2012; 61 / 636,577, filed on Apr. 20, 2012; 61 / 701,513, filed on Sep. 14, 2012; and 61 / 766,611, filed on Feb. 19, 2013; which applications are hereby incorporated by reference in their entireties.BACKGROUND OF THE DISCLOSURE[0002]Phototherapy has recently been recognized as having wide range of applications in both the medical, cosmetic and dental fields for use in surgeries, therapies and examinations. For example, phototherapy has been developed to treat cancers and tumors with lessened invasiveness. Phototherapy has also been used to disinfect target sites as an antimicrobial treatment. Phototherapy has also been found to promote wound healing.[0003]Photodynamic therapy is a type of phototherapy which involves a step of systemic administr...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61N5/06
CPCA61K41/00A61N5/06A61K8/042A61K8/22A61K8/498A61K8/8147A61K41/0042A61K41/0057A61N5/0616A61N5/062A61Q19/00A61Q19/02A61Q19/08A61K2800/262A61K2800/434A61K2800/5922A61K2800/81A61N2005/0645A61N2005/0647A61N2005/0662A61N2005/0663A61P1/02A61P17/00A61P17/02A61P17/10A61P29/00A61P43/00A61K9/06A61K9/48A61K31/352C09K11/02C09K11/06A61K9/0014
Inventor PIERGALLINI, REMIGIOLOUPIS, NIKOLAOSRASTOGI, SHIPRA
Owner KLOX TECH
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